{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:43:29Z","timestamp":1787917409134,"version":"build-2784847793"},"publisher-location":"Cham","reference-count":52,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032183750","type":"print"},{"value":"9783032183767","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-18376-7_8","type":"book-chapter","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T22:56:22Z","timestamp":1777244182000},"page":"153-167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Environmental Transgenerational Epigenetics: Effects on Fertility and Offspring Health"],"prefix":"10.1007","author":[{"given":"Sarah","family":"De Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"8_CR1","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1126\/science.1108190","volume":"308","author":"MD Anway","year":"2005","unstructured":"Anway MD, Cupp AS, Uzumcu M, Skinner MK (2005) Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308:1466\u20131469","journal-title":"Science"},{"key":"8_CR2","doi-asserted-by":"publisher","first-page":"5515","DOI":"10.1210\/en.2006-0640","volume":"147","author":"MD Anway","year":"2006","unstructured":"Anway MD, Leathers C, Skinner MK (2006) Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease. Endocrinology 147:5515\u20135523","journal-title":"Endocrinology"},{"key":"8_CR3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.meegid.2009.09.014","volume":"10","author":"FJ Ayala","year":"2010","unstructured":"Ayala FJ (2010) Darwin\u2019s explanation of design: from natural theology to natural selection. Infect Genet Evol 10:839\u2013842","journal-title":"Infect Genet Evol"},{"key":"8_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/eep\/dvy010","volume":"4","author":"M Ben Maamar","year":"2018","unstructured":"Ben Maamar M, Sadler-Riggleman I, Beck D, Mcbirney M, Nilsson E, Klukovich R, Xie Y, Tang C, Yan W, Skinner MK (2018) Alterations in sperm DNA methylation, non-coding RNA expression, and histone retention mediate vinclozolin-induced epigenetic transgenerational inheritance of disease. Environ Epigenet 4:1\u201319, dvy010","journal-title":"Environ Epigenet"},{"key":"8_CR5","doi-asserted-by":"publisher","first-page":"dvac024","DOI":"10.1093\/eep\/dvac024","volume":"8","author":"C Boscardin","year":"2022","unstructured":"Boscardin C, Manuella F, Mansuy IM (2022) Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice. Environ Epigenet 8:dvac024","journal-title":"Environ Epigenet"},{"key":"8_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0176155","volume":"12","author":"MJR Carvan","year":"2017","unstructured":"Carvan MJR, Kalluvila TA, Klingler RH, Larson JK, Pickens M, Mora-Zamorano FX, Connaughton VP, Sadler-Riggleman I, Beck D, Skinner MK (2017) Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish. PLoS One 12:1\u201326, e0176155","journal-title":"PLoS One"},{"key":"8_CR7","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1073\/pnas.45.6.828","volume":"45","author":"EH Coe","year":"1959","unstructured":"Coe EH (1959) A regular and continuing conversion-type phenomenon at the B locus in maize. Proc Natl Acad Sci USA 45:828\u2013832","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03170-6","volume":"11","author":"G Craig","year":"2021","unstructured":"Craig G, Kenny H, Nilsson E, Sadler-Riggleman I, Beck D, Skinner MK (2021) Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis. Sci Rep 11:23789","journal-title":"Sci Rep"},{"key":"8_CR9","doi-asserted-by":"crossref","unstructured":"D\u2019aniello C, Cermola F, Patriarca EJ, Minchiotti G (2019) Metabolic-epigenetic axis in pluripotent state transitions. Epigenomes 3","DOI":"10.3390\/epigenomes3030013"},{"key":"8_CR10","volume-title":"On the origin of species","author":"C Darwin","year":"1859","unstructured":"Darwin C (1859) On the origin of species. John Murray, London"},{"key":"8_CR11","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.21873\/anticanres.14134","volume":"40","author":"D Dragic","year":"2020","unstructured":"Dragic D, Ennour-Idrissi K, Michaud A, Chang SL, Durocher F, Diorio C (2020) Association between BMI and DNA methylation in blood or normal adult breast tissue: a systematic review. Anticancer Res 40:1797\u20131808","journal-title":"Anticancer Res"},{"key":"8_CR12","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1093\/biolre\/ioab018","volume":"104","author":"M Feijo","year":"2021","unstructured":"Feijo M, Martins RVL, Socorro S, Pereira L, Correia S (2021) Effects of the endocrine disruptor vinclozolin in male reproduction: a systematic review and meta-analysisdagger. Biol Reprod 104:962\u2013975","journal-title":"Biol Reprod"},{"key":"8_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2188\/jea.JE20180233","volume":"30","author":"R Fujii","year":"2020","unstructured":"Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Maeda K, Hagiwara C, Ando Y, Hashimoto S, Hamajima N, Suzuki K (2020) Associations of circulating MicroRNAs (miR-17, miR-21, and miR-150) and chronic kidney disease in a Japanese population. J Epidemiol 30:177\u2013182","journal-title":"J Epidemiol"},{"key":"8_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13148-020-00995-2","volume":"13","author":"N Garrido","year":"2021","unstructured":"Garrido N, Cruz F, Rivera Egea R, Simon C, Sadler-Riggleman I, Beck D, Nilsson E, Ben Maamar M, Skinner MK (2021) Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility. Clin Epigenetics 13:1\u201313","journal-title":"Clin Epigenetics"},{"key":"8_CR15","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/nutrit\/nuaa020","volume":"79","author":"K Gawlinska","year":"2021","unstructured":"Gawlinska K, Gawlinski D, Filip M, Przegalinski E (2021) Relationship of maternal high-fat diet during pregnancy and lactation to offspring health. Nutr Rev 79:709\u2013725","journal-title":"Nutr Rev"},{"key":"8_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.crvi.2016.05.009","volume":"339","author":"J Gayon","year":"2016","unstructured":"Gayon J (2016) From Mendel to epigenetics: history of genetics. C R Biol 339:225\u2013230","journal-title":"C R Biol"},{"key":"8_CR17","doi-asserted-by":"publisher","first-page":"2002715","DOI":"10.1002\/advs.202002715","volume":"8","author":"Y Gong","year":"2021","unstructured":"Gong Y, Xue Y, Li X, Zhang Z, Zhou W, Marcolongo P, Benedetti A, Mao S, Han L, Ding G, Sun Z (2021) Inter- and transgenerational effects of paternal exposure to inorganic arsenic. Adv Sci (Weinh) 8:2002715","journal-title":"Adv Sci (Weinh)"},{"key":"8_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0013100","volume":"5","author":"C Guerrero-Bosagna","year":"2010","unstructured":"Guerrero-Bosagna C, Settles M, Lucker BJ, Skinner MK (2010) Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS One 5:1\u201317, e13100","journal-title":"PLoS One"},{"key":"8_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jsbmb.2011.03.015","volume":"127","author":"TB Hayes","year":"2011","unstructured":"Hayes TB, Anderson LL, Beasley VR, De Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, Luque EH, Mccoy KA, Munoz-De-Toro M, Oka T, Oliveira CA, Orton F, Ruby S, Suzawa M, Tavera-Mendoza LE, Trudeau VL, Victor-Costa AB, Willingham E (2011) Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J Steroid Biochem Mol Biol 127:64\u201373","journal-title":"J Steroid Biochem Mol Biol"},{"key":"8_CR20","volume-title":"Evolution: the modern synthesis","author":"J Huxley","year":"1942","unstructured":"Huxley J (1942) Evolution: the modern synthesis. George Allen & Unwin Ltd, London"},{"key":"8_CR21","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1006\/taap.1994.1117","volume":"126","author":"WR Kelce","year":"1994","unstructured":"Kelce WR, Monosson E, Gamcsik MP, Laws SC, Gray LEJ (1994) Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol 126:276\u2013285","journal-title":"Toxicol Appl Pharmacol"},{"key":"8_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-38741-1","volume":"9","author":"R Klukovich","year":"2019","unstructured":"Klukovich R, Nilsson E, Sadler-Riggleman I, Beck D, Xie Y, Yan W, Skinner MK (2019) Environmental toxicant induced epigenetic transgenerational inheritance of prostate pathology and stromal-epithelial cell epigenome and transcriptome alterations: ancestral origins of prostate disease. Sci Rep 9:1\u201317","journal-title":"Sci Rep"},{"key":"8_CR23","doi-asserted-by":"publisher","first-page":"6372","DOI":"10.1038\/s41598-019-42860-0","volume":"9","author":"D Kubsad","year":"2019","unstructured":"Kubsad D, Nilsson EE, King SE, Sadler-Riggleman I, Beck D, Skinner MK (2019) Assessment of glyphosate induced epigenetic transgenerational inheritance of pathologies and sperm epimutations: generational toxicology. Sci Rep 9:6372","journal-title":"Sci Rep"},{"key":"8_CR24","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/ng.3185","volume":"47","author":"KB Kuchenbaecker","year":"2015","unstructured":"Kuchenbaecker KB, Ramus SJ, Tyrer J, Lee A, Shen HC, Beesley J, Lawrenson K, Mcguffog L, Healey S, Lee JM, Spindler TJ, Lin YG, Pejovic T, Bean Y, Li Q, Coetzee S, Hazelett D, Miron A, Southey M, Terry MB, Goldgar DE, Buys SS, Janavicius R, Dorfling CM, Van Rensburg EJ, Neuhausen SL, Ding YC, Hansen TV, Jonson L, Gerdes AM, Ejlertsen B, Barrowdale D, Dennis J, Benitez J, Osorio A, Garcia MJ, Komenaka I, Weitzel JN, Ganschow P, Peterlongo P, Bernard L, Viel A, Bonanni B, Peissel B, Manoukian S, Radice P, Papi L, Ottini L, Fostira F, Konstantopoulou I, Garber J, Frost D, Perkins J, Platte R, Ellis S, Embrace, Godwin AK, Schmutzler RK, Meindl A, Engel C, Sutter C, Sinilnikova OM, Collaborators GS, Damiola F, Mazoyer S, Stoppa-Lyonnet D, Claes K, De Leeneer K, Kirk J, Rodriguez GC, Piedmonte M, O\u2019malley DM, De La Hoya M, Caldes T, Aittomaki K, Nevanlinna H, Collee JM, Rookus MA, Oosterwijk JC, Breast Cancer Family R, Tihomirova L, Tung N, Hamann U, Isaccs C, Tischkowitz M, Imyanitov EN, Caligo MA, Campbell IG, Hogervorst FB, Hebon, Olah E, Diez O, Blanco I, Brunet J, Lazaro C, Pujana MA, Jakubowska A, Gronwald J, Lubinski J, Sukiennicki G et al (2015) Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet 47:164\u2013171","journal-title":"Nat Genet"},{"key":"8_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106472","volume":"152","author":"L Legoff","year":"2021","unstructured":"Legoff L, D\u2019cruz SC, Lebosq M, Gely-Pernot A, Bouchekhchoukha K, Monfort C, Kernanec PY, Tevosian S, Multigner L, Smagulova F (2021) Developmental exposure to chlordecone induces transgenerational effects in somatic prostate tissue which are associated with epigenetic histone trimethylation changes. Environ Int 152:106472","journal-title":"Environ Int"},{"key":"8_CR26","doi-asserted-by":"publisher","first-page":"16786","DOI":"10.1038\/s41598-019-52903-1","volume":"9","author":"S Luj\u00e1n","year":"2019","unstructured":"Luj\u00e1n S, Caroppo E, Niederberger C, Arce J-C, Sadler-Riggleman I, Beck D, Nilsson E, Skinner MK (2019) Sperm DNA methylation epimutation biomarkers for male infertility and FSH therapeutic responsiveness. Sci Rep 9:16786","journal-title":"Sci Rep"},{"key":"8_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0102091","volume":"9","author":"M Manikkam","year":"2014","unstructured":"Manikkam M, Haque MM, Guerrero-Bosagna C, Nilsson E, Skinner MK (2014) Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult onset disease through the female germline. PLoS One 9:1\u201319, e102091","journal-title":"PLoS One"},{"key":"8_CR28","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.reprotox.2012.08.010","volume":"34","author":"M Manikkam","year":"2012","unstructured":"Manikkam M, Tracey R, Guerrero-Bosagna C, Skinner M (2012a) Pesticide and insect repellent mixture (Permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations. Reprod Toxicol 34:708\u2013719","journal-title":"Reprod Toxicol"},{"key":"8_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0046249","volume":"7","author":"M Manikkam","year":"2012","unstructured":"Manikkam M, Tracey R, Guerrero-Bosagna C, Skinner MK (2012b) Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations. PLoS One 7:1\u201315, e46249","journal-title":"PLoS One"},{"key":"8_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0184306","volume":"12","author":"M Mcbirney","year":"2017","unstructured":"Mcbirney M, King SE, Pappalardo M, Houser E, Unkefer M, Nilsson E, Sadler-Riggleman I, Beck D, Winchester P, Skinner MK (2017) Atrazine induced epigenetic transgenerational inheritance of disease, lean phenotype and sperm epimutation pathology biomarkers. PLoS One 12:1\u201337, e0184306","journal-title":"PLoS One"},{"key":"8_CR31","first-page":"3","volume":"4","author":"G Mendel","year":"1866","unstructured":"Mendel G (1866) Versuche \u00fcber pflanzen-hybriden. Verhandlungen des naturforschenden Vereines in Br\u00fcnn 4:3\u201347","journal-title":"Verhandlungen des naturforschenden Vereines in Br\u00fcnn"},{"key":"8_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13059-016-1129-3","volume":"18","author":"K Mundbjerg","year":"2017","unstructured":"Mundbjerg K, Chopra S, Alemozaffar M, Duymich C, Lakshminarasimhan R, Nichols PW, Aron M, Siegmund KD, Ukimura O, Aron M, Stern M, Gill P, Carpten JD, Orntoft TF, Sorensen KD, Weisenberger DJ, Jones PA, Duddalwar V, Gill I, Liang G (2017) Identifying aggressive prostate cancer foci using a DNA methylation classifier. Genome Biol 18:3","journal-title":"Genome Biol"},{"key":"8_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0202662","volume":"13","author":"E Nilsson","year":"2018","unstructured":"Nilsson E, King SE, Mcbirney M, Kubsad D, Pappalardo M, Beck D, Sadler-Riggleman I, Skinner MK (2018) Vinclozolin induced epigenetic transgenerational inheritance of pathologies and sperm epimutation biomarkers for specific diseases. PLoS One 13:1\u201329, e0202662","journal-title":"PLoS One"},{"key":"8_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/eep\/dvac001","volume":"8","author":"EE Nilsson","year":"2022","unstructured":"Nilsson EE, Ben Maamar M, Skinner MK (2022) Role of epigenetic transgenerational inheritance in generational toxicology. Environ Epigenet 8:1\u20139, dvac001","journal-title":"Environ Epigenet"},{"key":"8_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/eep\/dvad006","volume":"9","author":"EE Nilsson","year":"2023","unstructured":"Nilsson EE, Mcbirney M, De Santos S, King SE, Beck D, Greeley C, Holder LB, Skinner MK (2023) Multiple generation distinct toxicant exposures induce epigenetic-transgenerational-inheritance of enhanced pathology and obesity. Environ Epigenet 9:1\u201319, dvad006","journal-title":"Environ Epigenet"},{"key":"8_CR36","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1017\/S2040174418000892","volume":"10","author":"M Penkler","year":"2019","unstructured":"Penkler M, Hanson M, Biesma R, Muller R (2019) DOHaD in science and society: emergent opportunities and novel responsibilities. J Dev Orig Health Dis 10:268\u2013273","journal-title":"J Dev Orig Health Dis"},{"key":"8_CR37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000130315","volume":"14","author":"AD Riggs","year":"1975","unstructured":"Riggs AD (1975) X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet 14:9\u201325","journal-title":"Cytogenet Cell Genet"},{"key":"8_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/eep\/dvz013","volume":"5","author":"I Sadler-Riggleman","year":"2019","unstructured":"Sadler-Riggleman I, Klukovich R, Nilsson E, Beck D, Xie Y, Yan W, Skinner MK (2019) Epigenetic transgenerational inheritance of testis pathology and sertoli cell epimutations: generational origins of male infertility. Environ Epigenet 5:1\u201318, dvz013","journal-title":"Environ Epigenet"},{"key":"8_CR39","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0003-2697(79)90363-4","volume":"94","author":"J Singer","year":"1979","unstructured":"Singer J, Schnute WC Jr, Shively JE, Todd CW, Riggs AD (1979) Sensitive detection of 5-methylcytosine and quantitation of the 5-methylcytosine\/cytosine ratio in DNA by gas chromatography--mass spectrometry using multiple specific ion monitoring. Anal Biochem 94:297\u2013301","journal-title":"Anal Biochem"},{"key":"8_CR40","doi-asserted-by":"publisher","first-page":"838","DOI":"10.4161\/epi.6.7.16537","volume":"6","author":"MK Skinner","year":"2011","unstructured":"Skinner MK (2011) Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability. Epigenetics 6:838\u2013842","journal-title":"Epigenetics"},{"key":"8_CR41","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.cmet.2023.11.015","volume":"36","author":"MK Skinner","year":"2024","unstructured":"Skinner MK (2024) Epigenetic biomarkers for disease susceptibility and preventative medicine. Cell Metab 36:263\u2013277","journal-title":"Cell Metab"},{"issue":"8","key":"8_CR42","first-page":"1","volume":"11","author":"MK Skinner","year":"2018","unstructured":"Skinner MK, Ben Maamar M, Sadler-Riggleman I, Beck D, Nilsson E, Mcbirney M, Klukovich R, Xie Y, Tang C, Yan W (2018) Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease. Epigenetics Chromatin 11(8):1\u201324","journal-title":"Epigenetics Chromatin"},{"issue":"228","key":"8_CR43","first-page":"1","volume":"11","author":"MK Skinner","year":"2013","unstructured":"Skinner MK, Manikkam M, Tracey R, Guerrero-Bosagna C, Haque MM, Nilsson E (2013) Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. BMC Med 11(228):1\u201316","journal-title":"BMC Med"},{"key":"8_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/eep\/dvab012","volume":"7","author":"MK Skinner","year":"2021","unstructured":"Skinner MK, Nilsson EE (2021) Role of environmentally induced epigenetic transgenerational inheritance in evolutionary biology: unified evolution theory. Environ Epigenet 7:1\u201312, dvab012","journal-title":"Environ Epigenet"},{"key":"8_CR45","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1093\/genetics\/162.2.917","volume":"162","author":"M Stam","year":"2002","unstructured":"Stam M, Belele C, Ramakrishna W, Dorweiler JE, Bennetzen JL, Chandler VL (2002) The regulatory regions required for B' paramutation and expression are located far upstream of the maize b1 transcribed sequences. Genetics 162:917\u2013930","journal-title":"Genetics"},{"key":"8_CR46","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.reprotox.2012.11.011","volume":"36","author":"R Tracey","year":"2013","unstructured":"Tracey R, Manikkam M, Guerrero-Bosagna C, Skinner M (2013) Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. Reprod Toxicol 36:104\u2013116","journal-title":"Reprod Toxicol"},{"key":"8_CR47","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/jez.b.22708","volume":"328","author":"AO Vargas","year":"2017","unstructured":"Vargas AO, Krabichler Q, Guerrero-Bosagna C (2017) An epigenetic perspective on the midwife toad experiments of Paul Kammerer (1880-1926). J Exp Zool B Mol Dev Evol 328:179\u2013192","journal-title":"J Exp Zool B Mol Dev Evol"},{"key":"8_CR48","volume-title":"Organisers and genes","author":"CH Waddington","year":"1940","unstructured":"Waddington CH (1940) Organisers and genes. Cambridge Univ. Press, Cambridge"},{"key":"8_CR49","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/479022a","volume":"479","author":"K Weintraub","year":"2011","unstructured":"Weintraub K (2011) The prevalence puzzle: autism counts. Nature 479:22\u201324","journal-title":"Nature"},{"key":"8_CR50","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1038\/s41598-022-07262-9","volume":"12","author":"P Winchester","year":"2022","unstructured":"Winchester P, Nilsson E, Beck D, Skinner MK (2022) Preterm birth buccal cell epigenetic biomarkers to facilitate preventative medicine. Sci Rep 12:3361","journal-title":"Sci Rep"},{"key":"8_CR51","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1093\/humupd\/dmz017","volume":"25","author":"MJ Xavier","year":"2019","unstructured":"Xavier MJ, Roman SD, Aitken RJ, Nixon B (2019) Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health. Hum Reprod Update 25:518\u2013540","journal-title":"Hum Reprod Update"},{"key":"8_CR52","doi-asserted-by":"publisher","first-page":"1079920","DOI":"10.3389\/fcell.2022.1079920","volume":"10","author":"J Zhai","year":"2022","unstructured":"Zhai J, Kongsberg WH, Pan Y, Hao C, Wang X, Sun J (2022) Caloric restriction induced epigenetic effects on aging. Front Cell Dev Biol 10:1079920","journal-title":"Front Cell Dev Biol"}],"container-title":["Advances in Experimental Medicine and Biology","Genetic and Epigenetic Damage in Human Spermatozoa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-18376-7_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T22:56:23Z","timestamp":1777244183000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-18376-7_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032183750","9783032183767"],"references-count":52,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-18376-7_8","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"22 February 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}