{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:01:25Z","timestamp":1780308085672,"version":"3.54.0"},"publisher-location":"Cham","reference-count":351,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032195081","type":"print"},{"value":"9783032195098","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-19509-8_12","type":"book-chapter","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:06:43Z","timestamp":1780304803000},"page":"275-317","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases"],"prefix":"10.1007","author":[{"given":"Maryam","family":"Faisal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"14","key":"12_CR1","doi-asserted-by":"publisher","first-page":"6607","DOI":"10.3390\/ijms26146607","volume":"26","author":"M Abbasi","year":"2025","unstructured":"Abbasi M et al (2025) Anti-obesity and metabolic effects of forskolin in obese C57BL\/6J mice. Int J Mol Sci 26(14):6607","journal-title":"Int J Mol Sci"},{"issue":"7","key":"12_CR2","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1161\/CIRCRESAHA.108.192765","volume":"104","author":"WA AbouAlaiwi","year":"2009","unstructured":"AbouAlaiwi WA et al (2009) Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ Res 104(7):860\u2013869","journal-title":"Circ Res"},{"issue":"2","key":"12_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.mcna.2019.10.007","volume":"104","author":"B Abramoff","year":"2020","unstructured":"Abramoff B, Caldera FE (2020) Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin North Am 104(2):293\u2013311","journal-title":"Med Clin North Am"},{"key":"12_CR350","doi-asserted-by":"publisher","unstructured":"Adel Al-Lami H, Barrell WB, Liu KJ (2016) Micrognathia in mouse models of ciliopathies. Biochem Soc Trans 44(6):1753\u20131759. https:\/\/doi.org\/10.1042\/bst20160241.\/p","DOI":"10.1042\/bst20160241.\/p"},{"issue":"1","key":"12_CR4","doi-asserted-by":"publisher","first-page":"4946","DOI":"10.1038\/s41467-025-60294-3","volume":"16","author":"M Ahmed","year":"2025","unstructured":"Ahmed M et al (2025) Cleavage of the Meckel-Gruber syndrome protein TMEM67 by ADAMTS9 uncouples Wnt signaling and ciliogenesis. Nat Commun 16(1):4946","journal-title":"Nat Commun"},{"issue":"11","key":"12_CR5","doi-asserted-by":"publisher","first-page":"3775","DOI":"10.1172\/JCI35711","volume":"118","author":"AO Aliprantis","year":"2008","unstructured":"Aliprantis AO et al (2008) NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118(11):3775\u20133789","journal-title":"J Clin Invest"},{"issue":"2","key":"12_CR6","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1074\/jbc.M116.767111","volume":"292","author":"I Antoniades","year":"2017","unstructured":"Antoniades I et al (2017) Addressing the functional determinants of FAK during ciliogenesis in multiciliated cells. J Biol Chem 292(2):488\u2013504","journal-title":"J Biol Chem"},{"issue":"4","key":"12_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41581-019-0116-9","volume":"15","author":"Z Anvarian","year":"2019","unstructured":"Anvarian Z et al (2019) Cellular signalling by primary cilia in development, organ function and disease. Nat Rev Nephrol 15(4):199\u2013219","journal-title":"Nat Rev Nephrol"},{"issue":"12","key":"12_CR8","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.tcb.2006.10.003","volume":"16","author":"A Arcangeli","year":"2006","unstructured":"Arcangeli A, Becchetti A (2006) Complex functional interaction between integrin receptors and ion channels. Trends Cell Biol 16(12):631\u2013639","journal-title":"Trends Cell Biol"},{"issue":"2","key":"12_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ecl.2021.03.009","volume":"50","author":"RM Arceo-Mendoza","year":"2021","unstructured":"Arceo-Mendoza RM, Camacho PM (2021) Postmenopausal osteoporosis: latest guidelines. Endocrinol Metab Clin N Am 50(2):167\u2013178","journal-title":"Endocrinol Metab Clin N Am"},{"issue":"6","key":"12_CR11","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1136\/jmg.2011.088864","volume":"48","author":"HH Arts","year":"2011","unstructured":"Arts HH et al (2011) C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome. J Med Genet 48(6):390\u2013395","journal-title":"J Med Genet"},{"issue":"4","key":"12_CR12","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1136\/jmg-2022-108435","volume":"60","author":"M Aubert-Mucca","year":"2023","unstructured":"Aubert-Mucca M et al (2023) Ellis-Van Creveld syndrome: clinical and molecular analysis of 50 individuals. J Med Genet 60(4):337\u2013345","journal-title":"J Med Genet"},{"issue":"4","key":"12_CR13","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.devcel.2009.10.003","volume":"17","author":"A Aulehla","year":"2009","unstructured":"Aulehla A, Pourquie O (2009) More than patterning\u2014hox genes and the control of posterior axial elongation. Dev Cell 17(4):439\u2013440","journal-title":"Dev Cell"},{"key":"12_CR14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/978-1-60761-369-5_11","volume":"584","author":"A Awan","year":"2010","unstructured":"Awan A et al (2010) Immunoflourescence and mRNA analysis of human embryonic stem cells (hESCs) grown under feeder-free conditions. Methods Mol Biol 584:195\u2013210","journal-title":"Methods Mol Biol"},{"issue":"1","key":"12_CR15","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1086\/510499","volume":"80","author":"L Baala","year":"2007","unstructured":"Baala L et al (2007) The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndrome. Am J Hum Genet 80(1):186\u2013194","journal-title":"Am J Hum Genet"},{"issue":"8","key":"12_CR16","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1136\/jmedgenet-2015-103087","volume":"52","author":"R Bachmann-Gagescu","year":"2015","unstructured":"Bachmann-Gagescu R et al (2015) Joubert syndrome: a model for untangling recessive disorders with extreme genetic heterogeneity. J Med Genet 52(8):514\u2013522","journal-title":"J Med Genet"},{"key":"12_CR17","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1146\/annurev.genom.7.080505.115610","volume":"7","author":"JL Badano","year":"2006","unstructured":"Badano JL et al (2006) The ciliopathies: an emerging class of human genetic disorders. Annu Rev Genomics Hum Genet 7:125\u2013148","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"2","key":"12_CR18","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/cge.12947","volume":"92","author":"N Badiner","year":"2017","unstructured":"Badiner N et al (2017) Mutations in DYNC2H1, the cytoplasmic dynein 2, heavy chain 1 motor protein gene, cause short-rib polydactyly type I, Saldino-Noonan type. Clin Genet 92(2):158\u2013165","journal-title":"Clin Genet"},{"issue":"5","key":"12_CR19","doi-asserted-by":"publisher","first-page":"L882","DOI":"10.1152\/ajplung.00033.2018","volume":"315","author":"KL Bailey","year":"2018","unstructured":"Bailey KL et al (2018) Oxidative stress associated with aging activates protein kinase C\u03b5, leading to cilia slowing. Am J Physiol Lung Cell Mol Physiol 315(5):L882\u2013l890","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"8","key":"12_CR20","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1073\/pnas.072650799","volume":"99","author":"G Baneyx","year":"2002","unstructured":"Baneyx G, Baugh L, Vogel V (2002) Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension. Proc Natl Acad Sci 99(8):5139\u20135143","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"12_CR21","doi-asserted-by":"publisher","first-page":"96","DOI":"10.4161\/org.27375","volume":"10","author":"AR Barker","year":"2014","unstructured":"Barker AR, Thomas R, Dawe HR (2014) Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development. Organogenesis 10(1):96\u2013107","journal-title":"Organogenesis"},{"issue":"1","key":"12_CR22","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/2046-2530-2-6","volume":"2","author":"SG Basten","year":"2013","unstructured":"Basten SG, Giles RH (2013) Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis. Cilia 2(1):6","journal-title":"Cilia"},{"key":"12_CR364","doi-asserted-by":"publisher","unstructured":"Basso N, Heersche JNM (2002) Characteristics of in vitro osteoblastic cell loading models. Bone 30(2):347\u2013351. https:\/\/doi.org\/10.1016\/S8756-3282(01)00678-0","DOI":"10.1016\/S8756-3282(01)00678-0"},{"issue":"4","key":"12_CR23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/MCD.0000000000000169","volume":"26","author":"A Bayat","year":"2017","unstructured":"Bayat A, Kerr B, Douzgou S (2017) The evolving craniofacial phenotype of a patient with Sensenbrenner syndrome caused by IFT140 compound heterozygous mutations. Clin Dysmorphol 26(4):247\u2013251","journal-title":"Clin Dysmorphol"},{"issue":"6","key":"12_CR24","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/ng2038","volume":"39","author":"PL Beales","year":"2007","unstructured":"Beales PL et al (2007) IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nat Genet 39(6):727\u2013729","journal-title":"Nat Genet"},{"issue":"13","key":"12_CR25","doi-asserted-by":"publisher","first-page":"R526","DOI":"10.1016\/j.cub.2009.05.025","volume":"19","author":"NF Berbari","year":"2009","unstructured":"Berbari NF et al (2009) The primary cilium as a complex signaling center. Curr Biol 19(13):R526\u2013R535","journal-title":"Curr Biol"},{"key":"12_CR26","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bone.2015.04.035","volume":"80","author":"AD Berendsen","year":"2015","unstructured":"Berendsen AD, Olsen BR (2015) Bone development. Bone 80:14\u201318. https:\/\/doi.org\/10.1016\/j.bone.2015.04.035","journal-title":"Bone"},{"issue":"2","key":"12_CR27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.cub.2009.11.072","volume":"20","author":"TY Besschetnova","year":"2010","unstructured":"Besschetnova TY et al (2010) Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol 20(2):182\u2013187","journal-title":"Curr Biol"},{"key":"12_CR330","doi-asserted-by":"publisher","unstructured":"Baldridge D et al (2010) Signaling pathways in human skeletal dysplasias. Annu Rev Genomics Hum Genet 11:189\u2013217. https:\/\/doi.org\/10.1146\/annurev-genom-082908-150158.\/p","DOI":"10.1146\/annurev-genom-082908-150158.\/p"},{"issue":"1","key":"12_CR28","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.1038\/s41598-017-03619-7","volume":"7","author":"J Bi","year":"2017","unstructured":"Bi J et al (2017) Suppression of \u03b1v\u03b26 integrin expression by polymicrobial oral biofilms in gingival epithelial cells. Sci Rep 7(1):4411","journal-title":"Sci Rep"},{"issue":"Pt 5","key":"12_CR29","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1242\/jcs.028621","volume":"122","author":"NJ Bialas","year":"2009","unstructured":"Bialas NJ et al (2009) Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins. J Cell Sci 122(Pt 5):611\u2013624","journal-title":"J Cell Sci"},{"issue":"4","key":"12_CR30","doi-asserted-by":"publisher","first-page":"ar26","DOI":"10.1091\/mbc.E22-06-0219","volume":"34","author":"BM Bigge","year":"2023","unstructured":"Bigge BM, Dougherty LL, Avasthi P (2023) Lithium-induced ciliary lengthening sparks Arp2\/3 complex\u2013dependent endocytosis. Mol Biol Cell 34(4):ar26","journal-title":"Mol Biol Cell"},{"issue":"11","key":"12_CR31","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911739","volume":"12","author":"M Bosakova","year":"2020","unstructured":"Bosakova M et al (2020) Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. EMBO Mol Med 12(11):e11739","journal-title":"EMBO Mol Med"},{"key":"12_CR325","doi-asserted-by":"publisher","unstructured":"Bronner ME, LeDouarin NM (2012) Development and evolution of the neural crest: an overview. Dev Biol 366(1):2\u20139. https:\/\/doi.org\/10.1016\/j.ydbio.2011.12.042.\/pp11","DOI":"10.1016\/j.ydbio.2011.12.042.\/pp11"},{"issue":"12","key":"12_CR32","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1093\/biosci\/biu174","volume":"64","author":"JM Brown","year":"2014","unstructured":"Brown JM, Witman GB (2014) Cilia and diseases. Bioscience 64(12):1126\u20131137","journal-title":"Bioscience"},{"issue":"18","key":"12_CR33","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1093\/hmg\/ddad109","volume":"32","author":"AL Bruel","year":"2023","unstructured":"Bruel AL et al (2023) Pathogenic RAB34 variants impair primary cilium assembly and cause a novel oral-facial-digital syndrome. Hum Mol Genet 32(18):2822\u20132831","journal-title":"Hum Mol Genet"},{"issue":"1","key":"12_CR34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1529\/biophysj.104.048280","volume":"89","author":"R Bruinsma","year":"2005","unstructured":"Bruinsma R (2005) Theory of force regulation by nascent adhesion sites. Biophys J 89(1):87\u201394","journal-title":"Biophys J"},{"issue":"7","key":"12_CR35","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.3390\/diagnostics11071218","volume":"11","author":"R Brunetti-Pierri","year":"2021","unstructured":"Brunetti-Pierri R et al (2021) Mild clinical presentation of Joubert syndrome in a male adult carrying biallelic MKS1 truncating variants. Diagnostics (Basel) 11(7):1218","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"12_CR36","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1093\/hmg\/ddu441","volume":"24","author":"KM Bujakowska","year":"2015","unstructured":"Bujakowska KM et al (2015) Mutations in IFT172 cause isolated retinal degeneration and Bardet-Biedl syndrome. Hum Mol Genet 24(1):230\u2013242","journal-title":"Hum Mol Genet"},{"issue":"11","key":"12_CR37","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.3390\/ijms26114971","volume":"26","author":"R Buqaileh","year":"2025","unstructured":"Buqaileh R, Alshriem LA, AbouAlaiwi W (2025) Ciliary G-protein coupled receptor signaling in polycystic kidney disease. Int J Mol Sci 26(11):4971","journal-title":"Int J Mol Sci"},{"issue":"3","key":"12_CR38","doi-asserted-by":"publisher","first-page":"a004994","DOI":"10.1101\/cshperspect.a004994","volume":"3","author":"ID Campbell","year":"2011","unstructured":"Campbell ID, Humphries MJ (2011) Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol 3(3):a004994","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"2","key":"12_CR39","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ajhg.2008.06.023","volume":"83","author":"V Cantagrel","year":"2008","unstructured":"Cantagrel V et al (2008) Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Am J Hum Genet 83(2):170\u2013179","journal-title":"Am J Hum Genet"},{"issue":"9","key":"12_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043291","volume":"7","author":"AB Castillo","year":"2012","unstructured":"Castillo AB et al (2012) Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo. PLoS One 7(9):e43291","journal-title":"PLoS One"},{"issue":"2","key":"12_CR41","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.joca.2011.11.009","volume":"20","author":"CF Chang","year":"2012","unstructured":"Chang CF, Ramaswamy G, Serra R (2012) Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis. Osteoarthr Cartil 20(2):152\u2013161","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"12_CR318","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrm2595","volume":"10","author":"M Chalfie","year":"2009","unstructured":"Chalfie M (2009) Neurosensory mechanotransduction. Nat Rev Mol Cell Biol 10(1):44\u201352. https:\/\/doi.org\/10.1038\/nrm2595","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"12_CR42","doi-asserted-by":"publisher","first-page":"C989","DOI":"10.1152\/ajpcell.2000.278.5.C989","volume":"278","author":"NX Chen","year":"2000","unstructured":"Chen NX et al (2000) Ca(2+) regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts. Am J Physiol Cell Physiol 278(5):C989\u2013C997","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"12_CR43","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1096\/fj.15-276402","volume":"30","author":"JC Chen","year":"2016","unstructured":"Chen JC et al (2016) Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism. FASEB J 30(4):1504\u20131511","journal-title":"FASEB J"},{"issue":"9","key":"12_CR44","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.3390\/ijms26094007","volume":"26","author":"N Chen","year":"2025","unstructured":"Chen N et al (2025) Mechanosignaling in osteoporosis: when cells feel the force. Int J Mol Sci 26(9):4007","journal-title":"Int J Mol Sci"},{"issue":"3","key":"12_CR45","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/00220345211046606","volume":"101","author":"Z Chinipardaz","year":"2022","unstructured":"Chinipardaz Z et al (2022) Role of primary cilia in bone and cartilage. J Dent Res 101(3):253\u2013260","journal-title":"J Dent Res"},{"issue":"1","key":"12_CR46","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0945-053X(03)00004-0","volume":"22","author":"M Chiquet","year":"2003","unstructured":"Chiquet M et al (2003) How do fibroblasts translate mechanical signals into changes in extracellular matrix production? Matrix Biol 22(1):73\u201380","journal-title":"Matrix Biol"},{"issue":"6","key":"12_CR47","doi-asserted-by":"publisher","first-page":"a028167","DOI":"10.1101\/cshperspect.a028167","volume":"9","author":"ST Christensen","year":"2017","unstructured":"Christensen ST et al (2017) Primary cilia and coordination of receptor tyrosine kinase (RTK) and transforming growth factor \u03b2 (TGF-\u03b2) signaling. Cold Spring Harb Perspect Biol 9(6):a028167","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6966","key":"12_CR48","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nature02196","volume":"426","author":"DE Clapham","year":"2003","unstructured":"Clapham DE (2003) TRP channels as cellular sensors. Nature 426(6966):517\u2013524","journal-title":"Nature"},{"issue":"6","key":"12_CR49","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1016\/j.celrep.2013.05.020","volume":"3","author":"CA Clement","year":"2013","unstructured":"Clement CA et al (2013) TGF-\u03b2 signaling is associated with endocytosis at the pocket region of the primary cilium. Cell Rep 3(6):1806\u20131814","journal-title":"Cell Rep"},{"key":"12_CR335","doi-asserted-by":"publisher","unstructured":"Clews C et al (2025) Taking a closer look at matrix vesicle biogenesis. J Bone Miner Res 40(8):931\u2013945. https:\/\/doi.org\/10.1093\/jbmr\/zjaf076.\/pp22","DOI":"10.1093\/jbmr\/zjaf076.\/pp22"},{"issue":"17","key":"12_CR50","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.cub.2008.07.046","volume":"18","author":"O Collin","year":"2008","unstructured":"Collin O et al (2008) Self-organized podosomes are dynamic mechanosensors. Curr Biol 18(17):1288\u20131294","journal-title":"Curr Biol"},{"issue":"7061","key":"12_CR51","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/nature04117","volume":"437","author":"KC Corbit","year":"2005","unstructured":"Corbit KC et al (2005) Vertebrate smoothened functions at the primary cilium. Nature 437(7061):1018\u20131021","journal-title":"Nature"},{"key":"12_CR359","doi-asserted-by":"publisher","unstructured":"Corbit KC et al (2008) Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol 10(1):70\u201376. https:\/\/doi.org\/10.1038\/ncb1670","DOI":"10.1038\/ncb1670"},{"issue":"3","key":"12_CR52","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ejmg.2017.11.011","volume":"61","author":"C C\u00f3rdova-Fletes","year":"2018","unstructured":"C\u00f3rdova-Fletes C et al (2018) Uncommon runs of homozygosity disclose homozygous missense mutations in two ciliopathy-related genes (SPAG17 and WDR35) in a patient with multiple brain and skeletal anomalies. Eur J Med Genet 61(3):161\u2013167","journal-title":"Eur J Med Genet"},{"issue":"1","key":"12_CR53","doi-asserted-by":"publisher","first-page":"3824","DOI":"10.1038\/s41598-018-22174-3","volume":"8","author":"MA Corrigan","year":"2018","unstructured":"Corrigan MA et al (2018) TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium. Sci Rep 8(1):3824","journal-title":"Sci Rep"},{"issue":"1","key":"12_CR54","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12915-024-01845-w","volume":"22","author":"A Coschiera","year":"2024","unstructured":"Coschiera A et al (2024) Primary cilia promote the differentiation of human neurons through the WNT signaling pathway. BMC Biol 22(1):48","journal-title":"BMC Biol"},{"key":"12_CR367","doi-asserted-by":"publisher","unstructured":"Cosman F et al (2024) Goal-directed osteoporosis treatment: ASBMR\/BHOF task force position statement 2024. J Bone Miner Res 39(10):1393\u20131405. https:\/\/doi.org\/10.1093\/jbmr\/zjae119","DOI":"10.1093\/jbmr\/zjae119"},{"issue":"6000","key":"12_CR55","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1126\/science.1193270","volume":"330","author":"B Coste","year":"2010","unstructured":"Coste B et al (2010) Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330(6000):55\u201360","journal-title":"Science"},{"key":"12_CR56","doi-asserted-by":"publisher","first-page":"111","DOI":"10.22203\/eCM.v032a07","volume":"32","author":"TR Coughlin","year":"2016","unstructured":"Coughlin TR et al (2016) Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture. Eur Cell Mater 32:111\u2013122","journal-title":"Eur Cell Mater"},{"issue":"1","key":"12_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.gimo.2023.100781","volume":"1","author":"JD Da Silva","year":"2023","unstructured":"Da Silva JD et al (2023) Establishing an objective clinical spectrum, genotype-phenotype correlations, and CRMP1 as a modifier in the Ellis-van Creveld syndrome: the first systematic review of EVC- and EVC2-associated conditions. Genet Med Open 1(1):100781","journal-title":"Genet Med Open"},{"issue":"7","key":"12_CR59","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1172\/JCI43639","volume":"121","author":"C Dafinger","year":"2011","unstructured":"Dafinger C et al (2011) Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest 121(7):2662\u20132667","journal-title":"J Clin Invest"},{"issue":"5","key":"12_CR60","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.ajhg.2009.04.016","volume":"84","author":"N Dagoneau","year":"2009","unstructured":"Dagoneau N et al (2009) DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome, type III. Am J Hum Genet 84(5):706\u2013711","journal-title":"Am J Hum Genet"},{"issue":"14","key":"12_CR61","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.1093\/hmg\/ddv137","volume":"24","author":"RR Damerla","year":"2015","unstructured":"Damerla RR et al (2015) Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies. Hum Mol Genet 24(14):3994\u20134005","journal-title":"Hum Mol Genet"},{"issue":"2","key":"12_CR62","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/glia.20741","volume":"57","author":"AI Danilov","year":"2009","unstructured":"Danilov AI et al (2009) Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone. Glia 57(2):136\u2013152","journal-title":"Glia"},{"issue":"3","key":"12_CR63","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/ng.756","volume":"43","author":"EE Davis","year":"2011","unstructured":"Davis EE et al (2011) TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. Nat Genet 43(3):189\u2013196","journal-title":"Nat Genet"},{"issue":"4","key":"12_CR64","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.ajhg.2017.08.017","volume":"101","author":"R De Mori","year":"2017","unstructured":"De Mori R et al (2017) Hypomorphic recessive variants in SUFU impair the sonic hedgehog pathway and cause Joubert syndrome with cranio-facial and skeletal defects. Am J Hum Genet 101(4):552\u2013563","journal-title":"Am J Hum Genet"},{"issue":"1","key":"12_CR65","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1096\/fj.13-231894","volume":"28","author":"RM Delaine-Smith","year":"2014","unstructured":"Delaine-Smith RM, Sittichokechaiwut A, Reilly GC (2014) Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts. FASEB J 28(1):430\u2013439","journal-title":"FASEB J"},{"issue":"3","key":"12_CR66","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cytogfr.2014.03.003","volume":"25","author":"JB Demoulin","year":"2014","unstructured":"Demoulin JB, Essaghir A (2014) PDGF receptor signaling networks in normal and cancer cells. Cytokine Growth Factor Rev 25(3):273\u2013283","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"12_CR67","first-page":"44","volume":"2","author":"JB Demoulin","year":"2012","unstructured":"Demoulin JB, Montano-Almendras CP (2012) Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis. Am J Blood Res 2(1):44\u201356","journal-title":"Am J Blood Res"},{"issue":"15","key":"12_CR68","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1096\/fasebj.7.15.8262332","volume":"7","author":"DT Denhardt","year":"1993","unstructured":"Denhardt DT, Guo X (1993) Osteopontin: a protein with diverse functions. FASEB J 7(15):1475\u20131482","journal-title":"FASEB J"},{"key":"12_CR352","doi-asserted-by":"publisher","unstructured":"Derderian C, Canales GI, Reiter JF (2023) Seriously cilia: a tiny organelle illuminates evolution, disease, and intercellular communication. Dev Cell 58(15):1333\u20131349. https:\/\/doi.org\/10.1016\/j.devcel.2023.06.013.\/pp41","DOI":"10.1016\/j.devcel.2023.06.013.\/pp41"},{"issue":"1","key":"12_CR70","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bbrc.2020.06.119","volume":"530","author":"D Ding","year":"2020","unstructured":"Ding D et al (2020) The microgravity induces the ciliary shortening and an increased ratio of anterograde\/retrograde intraflagellar transport of osteocytes. Biochem Biophys Res Commun 530(1):167\u2013172","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"12_CR71","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1038\/s41431-024-01634-7","volume":"32","author":"H Dollfus","year":"2024","unstructured":"Dollfus H et al (2024) Bardet-Biedl syndrome improved diagnosis criteria and management: inter European reference networks consensus statement and recommendations. Eur J Hum Genet 32(11):1347\u20131360","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"12_CR72","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1177\/1535370219892601","volume":"245","author":"G Du","year":"2020","unstructured":"Du G et al (2020) Roles of TRPV4 and piezo channels in stretch-evoked Ca(2+) response in chondrocytes. Exp Biol Med (Maywood) 245(3):180\u2013189","journal-title":"Exp Biol Med (Maywood)"},{"issue":"5","key":"12_CR73","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/BF00302070","volume":"57","author":"RL Duncan","year":"1995","unstructured":"Duncan RL, Turner CH (1995) Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int 57(5):344\u2013358","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"12_CR74","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ajhg.2009.12.007","volume":"86","author":"S Edvardson","year":"2010","unstructured":"Edvardson S et al (2010) Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation. Am J Hum Genet 86(1):93\u201397","journal-title":"Am J Hum Genet"},{"issue":"1","key":"12_CR75","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/2046-2530-1-15","volume":"1","author":"DL Egeberg","year":"2012","unstructured":"Egeberg DL et al (2012) Primary cilia and aberrant cell signaling in epithelial ovarian cancer. Cilia 1(1):15","journal-title":"Cilia"},{"issue":"3","key":"12_CR76","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/crj.12620","volume":"12","author":"N Emiralioglu","year":"2018","unstructured":"Emiralioglu N et al (2018) DYNC2H1 mutation causes Jeune syndrome and recurrent lung infections associated with ciliopathy. Clin Respir J 12(3):1017\u20131020","journal-title":"Clin Respir J"},{"issue":"2","key":"12_CR77","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1091\/mbc.E20-02-0111","volume":"32","author":"M Failler","year":"2021","unstructured":"Failler M et al (2021) Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis. Mol Biol Cell 32(2):169\u2013185","journal-title":"Mol Biol Cell"},{"key":"12_CR78","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/362753","volume":"2015","author":"RM Farahani","year":"2015","unstructured":"Farahani RM, Xaymardan M (2015) Platelet-derived growth factor receptor alpha as a marker of mesenchymal stem cells in development and stem cell biology. Stem Cells Int 2015:362753","journal-title":"Stem Cells Int"},{"issue":"3","key":"12_CR79","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1002\/ar.21330","volume":"294","author":"CE Farnum","year":"2011","unstructured":"Farnum CE, Wilsman NJ (2011) Orientation of primary cilia of articular chondrocytes in three-dimensional space. Anat Rec 294(3):533\u2013549","journal-title":"Anat Rec"},{"issue":"3","key":"12_CR80","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1086\/318802","volume":"68","author":"MI Ferrante","year":"2001","unstructured":"Ferrante MI et al (2001) Identification of the gene for oral-facial-digital type I syndrome. Am J Hum Genet 68(3):569\u2013576","journal-title":"Am J Hum Genet"},{"issue":"7392","key":"12_CR81","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nature10936","volume":"484","author":"AJ Firestone","year":"2012","unstructured":"Firestone AJ et al (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484(7392):125\u2013129","journal-title":"Nature"},{"issue":"1","key":"12_CR82","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/humu.20614","volume":"29","author":"V Frank","year":"2008","unstructured":"Frank V et al (2008) Mutations of the CEP290 gene encoding a centrosomal protein cause Meckel-Gruber syndrome. Hum Mutat 29(1):45\u201352","journal-title":"Hum Mutat"},{"issue":"1","key":"12_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ar.1092190104","volume":"219","author":"HM Frost","year":"1987","unstructured":"Frost HM (1987) Bone \u201cmass\u201d and the \u201cmechanostat\u201d: a proposal. Anat Rec 219(1):1\u20139","journal-title":"Anat Rec"},{"issue":"2","key":"12_CR84","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1002\/ar.a.10119","volume":"275","author":"HM Frost","year":"2003","unstructured":"Frost HM (2003) Bone\u2019s mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol 275(2):1081\u20131101","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"issue":"4","key":"12_CR85","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.proghi.2008.07.001","volume":"43","author":"RHW Funk","year":"2009","unstructured":"Funk RHW, Monsees T, \u00d6zkucur N (2009) Electromagnetic effects\u2014from cell biology to medicine. Prog Histochem Cytochem 43(4):177\u2013264","journal-title":"Prog Histochem Cytochem"},{"issue":"4","key":"12_CR86","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S1096-7192(02)00178-6","volume":"77","author":"M Galdzicka","year":"2002","unstructured":"Galdzicka M et al (2002) A new gene, EVC2, is mutated in Ellis-van Creveld syndrome. Mol Genet Metab 77(4):291\u2013295","journal-title":"Mol Genet Metab"},{"issue":"10","key":"12_CR87","doi-asserted-by":"publisher","first-page":"5291","DOI":"10.3390\/ijms25105291","volume":"25","author":"AN Gargalionis","year":"2024","unstructured":"Gargalionis AN et al (2024) Runx2 and polycystins in bone mechanotransduction: challenges for therapeutic opportunities. Int J Mol Sci 25(10):5291","journal-title":"Int J Mol Sci"},{"issue":"5","key":"12_CR88","doi-asserted-by":"publisher","first-page":"a005033","DOI":"10.1101\/cshperspect.a005033","volume":"3","author":"B Geiger","year":"2011","unstructured":"Geiger B, Yamada KM (2011) Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol 3(5):a005033","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"12_CR89","doi-asserted-by":"publisher","first-page":"9272","DOI":"10.1038\/s41598-021-88633-6","volume":"11","author":"IP Geoghegan","year":"2021","unstructured":"Geoghegan IP, McNamara LM, Hoey DA (2021) Estrogen withdrawal alters cytoskeletal and primary ciliary dynamics resulting in increased Hedgehog and osteoclastogenic paracrine signalling inosteocytes. Sci Rep 11(1):9272. https:\/\/doi.org\/10.1038\/s41598-021-88633-6.\/pp206","journal-title":"Sci Rep"},{"issue":"1","key":"12_CR90","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cell.2009.03.023","volume":"137","author":"JM Gerdes","year":"2009","unstructured":"Gerdes JM, Davis EE, Katsanis N (2009) The vertebrate primary cilium in development, homeostasis, and disease. Cell 137(1):32\u201345","journal-title":"Cell"},{"issue":"2","key":"12_CR91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057545","volume":"8","author":"C Gerhardt","year":"2013","unstructured":"Gerhardt C et al (2013) The ciliary protein Ftm is required for ventricular wall and septal development. PLoS One 8(2):e57545","journal-title":"PLoS One"},{"issue":"8","key":"12_CR92","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1021\/acschembio.4c00186","volume":"19","author":"AA Gholkar","year":"2024","unstructured":"Gholkar AA et al (2024) MI-181 modulates cilia length and restores cilia length in cells with defective shortened cilia. ACS Chem Biol 19(8):1733\u20131742","journal-title":"ACS Chem Biol"},{"issue":"6","key":"12_CR93","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.377","volume":"9","author":"ED Gigante","year":"2020","unstructured":"Gigante ED, Caspary T (2020) Signaling in the primary cilium through the lens of the hedgehog pathway. WIREs Dev Biol 9(6):e377","journal-title":"WIREs Dev Biol"},{"issue":"3","key":"12_CR94","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.ajhg.2010.08.004","volume":"87","author":"C Gilissen","year":"2010","unstructured":"Gilissen C et al (2010) Exome sequencing identifies WDR35 variants involved in Sensenbrenner syndrome. Am J Hum Genet 87(3):418\u2013423","journal-title":"Am J Hum Genet"},{"issue":"2","key":"12_CR95","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1083\/jcb.53.2.494","volume":"53","author":"NB Gilula","year":"1972","unstructured":"Gilula NB, Satir P (1972) The ciliary necklace. A ciliary membrane specialization. J Cell Biol 53(2):494\u2013509. https:\/\/doi.org\/10.1083\/jcb.53.2.494.\/p","journal-title":"J Cell Biol"},{"issue":"6","key":"12_CR96","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/cge.12762","volume":"90","author":"KM Girisha","year":"2016","unstructured":"Girisha KM et al (2016) A homozygous nonsense variant in IFT52 is associated with a human skeletal ciliopathy. Clin Genet 90(6):536\u2013539","journal-title":"Clin Genet"},{"issue":"1","key":"12_CR97","doi-asserted-by":"publisher","first-page":"27806","DOI":"10.1038\/srep27806","volume":"6","author":"GM Goldgof","year":"2016","unstructured":"Goldgof GM et al (2016) Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. Sci Rep 6(1):27806","journal-title":"Sci Rep"},{"issue":"5","key":"12_CR98","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ajhg.2008.10.002","volume":"83","author":"NT Gorden","year":"2008","unstructured":"Gorden NT et al (2008) CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290. Am J Hum Genet 83(5):559\u2013571","journal-title":"Am J Hum Genet"},{"issue":"7","key":"12_CR99","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1158\/0008-5472.CAN-12-2938","volume":"73","author":"SA Gradilone","year":"2013","unstructured":"Gradilone SA et al (2013) HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res 73(7):2259\u20132270","journal-title":"Cancer Res"},{"issue":"5","key":"12_CR100","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.ajhg.2013.09.012","volume":"93","author":"J Halbritter","year":"2013","unstructured":"Halbritter J et al (2013) Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans. Am J Hum Genet 93(5):915\u2013925","journal-title":"Am J Hum Genet"},{"issue":"1","key":"12_CR101","doi-asserted-by":"publisher","first-page":"15585","DOI":"10.1038\/s41598-017-15442-1","volume":"7","author":"A Hammarsj\u00f6","year":"2017","unstructured":"Hammarsj\u00f6 A et al (2017) Novel KIAA0753 mutations extend the phenotype of skeletal ciliopathies. Sci Rep 7(1):15585","journal-title":"Sci Rep"},{"key":"12_CR102","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3389\/fped.2017.00244","volume":"5","author":"V Hartill","year":"2017","unstructured":"Hartill V et al (2017) Meckel-Gruber syndrome: an update on diagnosis, clinical management, and research advances. Front Pediatr 5:244","journal-title":"Front Pediatr"},{"issue":"5","key":"12_CR103","first-page":"3","volume":"37 Suppl 120","author":"GA Hawker","year":"2019","unstructured":"Hawker GA (2019) Osteoarthritis is a serious disease. Clin Exp Rheumatol 37 Suppl 120(5):3\u20136","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"12_CR104","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1242\/dev.02732","volume":"134","author":"CJ Haycraft","year":"2007","unstructured":"Haycraft CJ et al (2007) Intraflagellar transport is essential for endochondral bone formation. Development 134(2):307\u2013316","journal-title":"Development"},{"issue":"8","key":"12_CR105","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009100","volume":"5","author":"CH Heldin","year":"2013","unstructured":"Heldin CH, Lennartsson J (2013) Structural and functional properties of platelet-derived growth factor and stem cell factor receptors. Cold Spring Harb Perspect Biol 5(8):a009100","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"12_CR106","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s40246-017-0111-9","volume":"11","author":"BM Helm","year":"2017","unstructured":"Helm BM et al (2017) Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome. Hum Genomics 11(1):16","journal-title":"Hum Genomics"},{"issue":"12","key":"12_CR107","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1172\/JCI200319826","volume":"112","author":"JG Hoenderop","year":"2003","unstructured":"Hoenderop JG et al (2003) Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112(12):1906\u20131914","journal-title":"J Clin Invest"},{"issue":"1","key":"12_CR108","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.bbrc.2011.07.072","volume":"412","author":"DA Hoey","year":"2011","unstructured":"Hoey DA, Kelly DJ, Jacobs CR (2011) A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. Biochem Biophys Res Commun 412(1):182\u2013187","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR361","doi-asserted-by":"publisher","unstructured":"Hoffman BD, Grashoff C, Schwartz MA (2011) Dynamic molecular processes mediate cellular mechanotransduction. Nature 475(7356):316\u2013323. https:\/\/doi.org\/10.1038\/nature10316.\/pp138","DOI":"10.1038\/nature10316.\/pp138"},{"key":"12_CR332","doi-asserted-by":"publisher","unstructured":"Hojo H, Tani S, Ohba S (2024) Modeling of skeletal development and diseases using human pluripotent stem cells. J Bone Miner Res 40(1):5\u201319. https:\/\/doi.org\/10.1093\/jbmr\/zjae178.\/pp19","DOI":"10.1093\/jbmr\/zjae178.\/pp19"},{"key":"12_CR109","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bone.2014.02.005","volume":"62","author":"JM Hong","year":"2014","unstructured":"Hong JM et al (2014) Electromagnetically controllable osteoclast activity. Bone 62:99\u2013107","journal-title":"Bone"},{"issue":"1","key":"12_CR110","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/pr.2013.200","volume":"75","author":"A Horani","year":"2014","unstructured":"Horani A, Brody SL, Ferkol TW (2014) Picking up speed: advances in the genetics of primary ciliary dyskinesia. Pediatr Res 75(1):158\u2013164","journal-title":"Pediatr Res"},{"issue":"3","key":"12_CR322","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/sj.jid.5700613","volume":"127","author":"B Hinz","year":"2007","unstructured":"Hinz B (2007) Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 127(3):526\u2013537. https:\/\/doi.org\/10.1038\/sj.jid.5700613","journal-title":"J Invest Dermatol"},{"issue":"32","key":"12_CR111","doi-asserted-by":"publisher","first-page":"11325","DOI":"10.1073\/pnas.0505328102","volume":"102","author":"D Huangfu","year":"2005","unstructured":"Huangfu D, Anderson KV (2005) Cilia and hedgehog responsiveness in the mouse. Proc Natl Acad Sci 102(32):11325\u201311330","journal-title":"Proc Natl Acad Sci"},{"issue":"6962","key":"12_CR112","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nature02061","volume":"426","author":"D Huangfu","year":"2003","unstructured":"Huangfu D et al (2003) Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426(6962):83\u201387","journal-title":"Nature"},{"issue":"11","key":"12_CR113","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1093\/hmg\/ddw093","volume":"25","author":"H Husson","year":"2016","unstructured":"Husson H et al (2016) Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis. Hum Mol Genet 25(11):2245\u20132255","journal-title":"Hum Mol Genet"},{"issue":"6","key":"12_CR114","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","volume":"110","author":"RO Hynes","year":"2002","unstructured":"Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6):673\u2013687. https:\/\/doi.org\/10.1016\/s0092-8674(02)00971-6.\/pp176","journal-title":"Cell"},{"key":"12_CR362","doi-asserted-by":"publisher","unstructured":"Ingber DE (2006) Cellular mechanotransduction: putting all the pieces together again. Faseb J 20(7):811\u2013827. https:\/\/doi.org\/10.1096\/fj.05-5424rev.\/pp139","DOI":"10.1096\/fj.05-5424rev.\/pp139"},{"issue":"2","key":"12_CR115","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.jbiomech.2013.11.040","volume":"47","author":"J Irianto","year":"2014","unstructured":"Irianto J et al (2014) Depletion of chondrocyte primary cilia reduces the compressivemodulus of articular cartilage. J Biomech 47(2):579\u2013582. https:\/\/doi.org\/10.1016\/j.jbiomech.2013.11.040.\/pp272","journal-title":"J Biomech"},{"issue":"3\u20134","key":"12_CR116","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/hmg\/ddab034","volume":"30","author":"Y Ishida","year":"2021","unstructured":"Ishida Y et al (2021) Molecular basis of ciliary defects caused by compound heterozygous IFT144\/WDR19 mutations found in cranioectodermal dysplasia. Hum Mol Genet 30(3\u20134):213\u2013225","journal-title":"Hum Mol Genet"},{"key":"12_CR353","doi-asserted-by":"publisher","unstructured":"Ishikawa H, Marshall WF (2011) Ciliogenesis: building the cell's antenna. Nat Rev Mol Cell Biol 12(4):222\u2013234. https:\/\/doi.org\/10.1038\/nrm3085.\/pp42","DOI":"10.1038\/nrm3085.\/pp42"},{"key":"12_CR117","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jare.2023.12.008","volume":"65","author":"C Iwaya","year":"2024","unstructured":"Iwaya C, Suzuki A, Iwata J (2024) Loss of Sc5d results in micrognathia due to a failure in osteoblast differentiation. J Adv Res 65:153\u2013165","journal-title":"J Adv Res"},{"issue":"11","key":"12_CR118","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1007\/s00018-013-1483-1","volume":"71","author":"X Jin","year":"2014","unstructured":"Jin X et al (2014) Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli. Cell Mol Life Sci 71(11):2165\u20132178","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"12_CR119","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41392-023-01559-5","volume":"8","author":"J Jing","year":"2023","unstructured":"Jing J et al (2023) Hedgehog signaling in tissue homeostasis, cancers and targeted therapies. Signal Transduct Target Ther 8(1):315","journal-title":"Signal Transduct Target Ther"},{"issue":"21","key":"12_CR120","doi-asserted-by":"publisher","first-page":"jcs222737","DOI":"10.1242\/jcs.222737","volume":"131","author":"GP Johnson","year":"2018","unstructured":"Johnson GP et al (2018) Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium. J Cell Sci 131(21):jcs222737","journal-title":"J Cell Sci"},{"key":"12_CR121","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.115846","volume":"145","author":"GP Johnson","year":"2021","unstructured":"Johnson GP, Fair S, Hoey DA (2021) Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling. Bone 145:115846","journal-title":"Bone"},{"issue":"5","key":"12_CR122","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.mcna.2020.06.004","volume":"104","author":"CB Johnston","year":"2020","unstructured":"Johnston CB, Dagar M (2020) Osteoporosis in older adults. Med Clin North Am 104(5):873\u2013884","journal-title":"Med Clin North Am"},{"issue":"5","key":"12_CR123","doi-asserted-by":"publisher","first-page":"183206","DOI":"10.1016\/j.bbamem.2020.183206","volume":"2020","author":"YA Kadry","year":"1862","unstructured":"Kadry YA, Calderwood DA (2020) Chapter 22: Structural and signaling functions of integrins. Biochim Biophys Acta Biomembr 1862(5):183206. https:\/\/doi.org\/10.1016\/j.bbamem.2020.183206.\/p","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"2","key":"12_CR124","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s11914-017-0351-6","volume":"15","author":"M Kaku","year":"2017","unstructured":"Kaku M, Komatsu Y (2017) Functional diversity of ciliary proteins in bone development and disease. Curr Osteoporos Rep 15(2):96\u2013102","journal-title":"Curr Osteoporos Rep"},{"issue":"2","key":"12_CR125","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3892\/ijmm.2012.1220","volume":"31","author":"S Kameyama","year":"2013","unstructured":"Kameyama S et al (2013) Short-term mechanical stress inhibits osteoclastogenesis via suppression of DC-STAMP in RAW264.7 cells. Int J Mol Med 31(2):292\u2013298","journal-title":"Int J Mol Med"},{"issue":"12","key":"12_CR126","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3858\/emm.2012.44.12.080","volume":"44","author":"SS Kang","year":"2012","unstructured":"Kang SS et al (2012) Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation. Exp Mol Med 44(12):707\u2013722","journal-title":"Exp Mol Med"},{"issue":"13","key":"12_CR127","doi-asserted-by":"publisher","first-page":"12001","DOI":"10.1074\/jbc.R300038200","volume":"279","author":"A Katsumi","year":"2004","unstructured":"Katsumi A et al (2004) Integrins in mechanotransduction. J Biol Chem 279(13):12001\u201312004","journal-title":"J Biol Chem"},{"issue":"5","key":"12_CR128","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/ajmg.a.33892","volume":"155a","author":"KM Keppler-Noreuil","year":"2011","unstructured":"Keppler-Noreuil KM et al (2011) Clinical insights gained from eight new cases and review of reported cases with Jeune syndrome (asphyxiating thoracic dystrophy). Am J Med Genet A 155a(5):1021\u20131032","journal-title":"Am J Med Genet A"},{"issue":"9","key":"12_CR129","doi-asserted-by":"publisher","first-page":"9975","DOI":"10.18632\/oncotarget.7198","volume":"7","author":"NA Khan","year":"2016","unstructured":"Khan NA et al (2016) Identification of drugs that restore primary cilium expression in cancer cells. Oncotarget 7(9):9975","journal-title":"Oncotarget"},{"issue":"1","key":"12_CR130","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/sj.cr.7290106","volume":"12","author":"C Kiani","year":"2002","unstructured":"Kiani C et al (2002) Structure and function of aggrecan. Cell Res 12(1):19\u201332","journal-title":"Cell Res"},{"issue":"7291","key":"12_CR131","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/nature08895","volume":"464","author":"J Kim","year":"2010","unstructured":"Kim J et al (2010) Functional genomic screen for modulators of ciliogenesis and cilium length. Nature 464(7291):1048\u20131051","journal-title":"Nature"},{"issue":"4","key":"12_CR132","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/ncb2183","volume":"13","author":"S Kim","year":"2011","unstructured":"Kim S et al (2011) Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol 13(4):351\u2013360","journal-title":"Nat Cell Biol"},{"issue":"1","key":"12_CR133","doi-asserted-by":"publisher","first-page":"6781","DOI":"10.1038\/ncomms7781","volume":"6","author":"J Kim","year":"2015","unstructured":"Kim J et al (2015) Actin remodelling factors control ciliogenesis by regulating YAP\/TAZ activity and vesicle trafficking. Nat Commun 6(1):6781","journal-title":"Nat Commun"},{"issue":"1","key":"12_CR134","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbrc.2018.12.107","volume":"509","author":"M Kitami","year":"2019","unstructured":"Kitami M et al (2019) IFT20 is required for the maintenance of cartilaginous matrix in condylar cartilage. Biochem Biophys Res Commun 509(1):222\u2013226","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"12_CR135","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/0022-510X(69)90091-4","volume":"9","author":"D Klein","year":"1969","unstructured":"Klein D, Ammann F (1969) The syndrome of Laurence-Moon-Bardet-Biedl and allied diseases in Switzerland. Clinical, genetic and epidemiological studies. J Neurol Sci 9(3):479\u2013513","journal-title":"J Neurol Sci"},{"issue":"3","key":"12_CR319","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3390\/biom15030354","volume":"15","author":"M Kloc","year":"2025","unstructured":"Kloc M, Wosik J (2025) Mechanical forces, nucleus, chromosomes, and chromatin. Biomolecules 15(3):354. https:\/\/doi.org\/10.3390\/biom15030354","journal-title":"Biomolecules"},{"key":"12_CR136","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.biocel.2018.04.013","volume":"99","author":"L Koivisto","year":"2018","unstructured":"Koivisto L et al (2018) Integrin \u03b1v\u03b26: structure, function and role in health and disease. Int J Biochem Cell Biol 99:186\u2013196","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"12_CR137","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s13730-015-0210-1","volume":"5","author":"Y Komatsu","year":"2016","unstructured":"Komatsu Y et al (2016) TMEM67 mutations found in a case of Joubert syndrome with renal hypodysplasia. CEN Case Rep 5(2):137\u2013140","journal-title":"CEN Case Rep"},{"issue":"10","key":"12_CR138","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1002\/ajmg.a.33013","volume":"149a","author":"AE Konstantinidou","year":"2009","unstructured":"Konstantinidou AE et al (2009) Cranioectodermal dysplasia: a probable ciliopathy. Am J Med Genet A 149a(10):2206\u20132211","journal-title":"Am J Med Genet A"},{"key":"12_CR331","doi-asserted-by":"publisher","unstructured":"Kovacs CS et al (2021) The role of biomineralization in disorders of skeletal development and tooth formation. Nat Rev Endocrinol 17(6):336\u2013349. https:\/\/doi.org\/10.1038\/s41574-021-00488-z","DOI":"10.1038\/s41574-021-00488-z"},{"issue":"11","key":"12_CR139","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1242\/dev.001586","volume":"134","author":"E Koyama","year":"2007","unstructured":"Koyama E et al (2007) Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development 134(11):2159\u20132169","journal-title":"Development"},{"issue":"12","key":"12_CR140","doi-asserted-by":"publisher","first-page":"5519","DOI":"10.1073\/pnas.90.12.5519","volume":"90","author":"KG Kozminski","year":"1993","unstructured":"Kozminski KG et al (1993) A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc Natl Acad Sci 90(12):5519\u20135523","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"12_CR141","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ajhg.2009.01.021","volume":"84","author":"D Krakow","year":"2009","unstructured":"Krakow D et al (2009) Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet 84(3):307\u2013315","journal-title":"Am J Hum Genet"},{"issue":"11","key":"12_CR142","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/cm.21873","volume":"81","author":"A Kumari","year":"2024","unstructured":"Kumari A et al (2024) TNF-alpha promotes cilia elongation via mixed lineage kinases signaling in mouse fibroblasts and human RPE-1 cells. Cytoskeleton 81(11):639\u2013647","journal-title":"Cytoskeleton"},{"issue":"10","key":"12_CR143","doi-asserted-by":"publisher","first-page":"4316","DOI":"10.1073\/pnas.1800338116","volume":"116","author":"M Kunova Bosakova","year":"2019","unstructured":"Kunova Bosakova M et al (2019) Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. Proc Natl Acad Sci 116(10):4316\u20134325","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"12_CR144","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/ncb2259","volume":"13","author":"MA Lancaster","year":"2011","unstructured":"Lancaster MA, Schroth J, Gleeson JG (2011) Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat Cell Biol 13(6):700\u2013707","journal-title":"Nat Cell Biol"},{"issue":"1","key":"12_CR145","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13630-015-0016-y","volume":"4","author":"KL Lee","year":"2015","unstructured":"Lee KL et al (2015) The primary cilium functions as a mechanical and calcium signaling nexus. Cilia 4(1):7","journal-title":"Cilia"},{"issue":"12","key":"12_CR323","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/s41574-025-01162-4","volume":"21","author":"B Lecka-Czernik","year":"2025","unstructured":"Lecka-Czernik B, Rosen CJ, Napoli N (2025) The role of bone in whole-body energy metabolism. Nat Rev Endocrinol 21(12):743\u2013756. https:\/\/doi.org\/10.1038\/s41574-025-01162-4","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"12_CR146","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1093\/hmg\/ddt054","volume":"22","author":"AC Leightner","year":"2013","unstructured":"Leightner AC et al (2013) The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarity. Hum Mol Genet 22(10):2024\u20132040","journal-title":"Hum Mol Genet"},{"issue":"4","key":"12_CR147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000390","volume":"2","author":"P Leucht","year":"2007","unstructured":"Leucht P et al (2007) FAK-mediated mechanotransduction in skeletal regeneration. PLoS One 2(4):e390","journal-title":"PLoS One"},{"issue":"3","key":"12_CR148","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.medengphy.2012.06.005","volume":"35","author":"P Leucht","year":"2013","unstructured":"Leucht P et al (2013) Primary cilia act as mechanosensors during bone healing around an implant. Med Eng Phys 35(3):392\u2013402","journal-title":"Med Eng Phys"},{"issue":"7","key":"12_CR149","first-page":"805","volume":"9","author":"CF Li","year":"1995","unstructured":"Li CF et al (1995) Estrogen enhances alpha v beta 3 integrin expression by avian osteoclast precursors via stabilization of beta 3 integrin mRNA. Mol Endocrinol 9(7):805\u2013813","journal-title":"Mol Endocrinol"},{"issue":"48","key":"12_CR317","doi-asserted-by":"publisher","first-page":"30455","DOI":"10.1074\/jbc.272.48.30455","volume":"272","author":"S Li","year":"1997","unstructured":"Li S et al (1997) Fluid shear stress activation of focal adhesion kinase. linking to mitogen-activated protein kinases. J Biol Chem 272(48):30455\u201330462. https:\/\/doi.org\/10.1074\/jbc.272.48.30455","journal-title":"J Biol Chem"},{"issue":"7526","key":"12_CR150","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nature13701","volume":"515","author":"J Li","year":"2014","unstructured":"Li J et al (2014) Piezo1 integration of vascular architecture with physiological force. Nature 515(7526):279\u2013282","journal-title":"Nature"},{"key":"12_CR151","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49631","volume":"8","author":"X Li","year":"2019","unstructured":"Li X et al (2019) Stimulation of Piezo1 by mechanical signals promotes bone anabolism. elife 8:e49631","journal-title":"elife"},{"issue":"1","key":"12_CR152","first-page":"C73","volume":"318","author":"Y-H Li","year":"2020","unstructured":"Li Y-H et al (2020) Primary cilia respond to intermittent low-magnitude, high-frequency vibration and mediate vibration-induced effects in osteoblasts. Am J Phys Cell Phys 318(1):C73\u2013C82","journal-title":"Am J Phys Cell Phys"},{"key":"12_CR153","doi-asserted-by":"publisher","first-page":"6063423","DOI":"10.1155\/2022\/6063423","volume":"2022","author":"X Li","year":"2022","unstructured":"Li X et al (2022) Role of primary cilia in skeletal disorders. Stem Cells Int 2022:6063423","journal-title":"Stem Cells Int"},{"key":"12_CR154","doi-asserted-by":"publisher","first-page":"1259650","DOI":"10.3389\/fendo.2023.1259650","volume":"14","author":"F Lian","year":"2023","unstructured":"Lian F et al (2023) Recent advances in primary cilia in bone metabolism. Front Endocrinol (Lausanne) 14:1259650","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"12_CR155","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1159\/000430253","volume":"37","author":"W Liang","year":"2015","unstructured":"Liang W et al (2015) Integrin \u03b21 gene therapy enhances in vitro creation of tissue-engineered cartilage under periodic mechanical stress. Cell Physiol Biochem 37(4):1301\u20131314","journal-title":"Cell Physiol Biochem"},{"key":"12_CR156","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fendo.2012.00099","volume":"3","author":"L Lieben","year":"2012","unstructured":"Lieben L, Carmeliet G (2012) The involvement of TRP channels in bone homeostasis. Front Endocrinol (Lausanne) 3:99","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"11","key":"12_CR157","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1002\/ajmg.a.36265","volume":"161a","author":"AE Lin","year":"2013","unstructured":"Lin AE et al (2013) Sensenbrenner syndrome (Cranioectodermal dysplasia): clinical and molecular analyses of 39 patients including two new patients. Am J Med Genet A 161a(11):2762\u20132776","journal-title":"Am J Med Genet A"},{"key":"12_CR158","doi-asserted-by":"publisher","first-page":"1039714","DOI":"10.3389\/fphys.2022.1039714","volume":"13","author":"Y Lin","year":"2022","unstructured":"Lin Y, Ren J, McGrath C (2022) Mechanosensitive Piezo1 and Piezo2 ion channels in craniofacial development and dentistry: recent advances and prospects. Front Physiol 13:1039714","journal-title":"Front Physiol"},{"issue":"3","key":"12_CR159","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/jbmr.3902","volume":"35","author":"M Liu","year":"2020","unstructured":"Liu M et al (2020) IFT80 is required for fracture healing through controlling the regulation of TGF-\u03b2 signaling in chondrocyte differentiation and function. J Bone Miner Res 35(3):571\u2013582","journal-title":"J Bone Miner Res"},{"key":"12_CR160","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.830722","volume":"10","author":"P Liu","year":"2022","unstructured":"Liu P et al (2022) Effects of mechanical stress stimulation on function and expression mechanism of osteoblasts. Front Bioeng Biotechnol 10:830722","journal-title":"Front Bioeng Biotechnol"},{"issue":"6","key":"12_CR161","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.neuron.2011.03.002","volume":"69","author":"A Louvi","year":"2011","unstructured":"Louvi A, Grove EA (2011) Cilia in the CNS: the quiet organelle claims center stage. Neuron 69(6):1046\u20131060","journal-title":"Neuron"},{"issue":"33","key":"12_CR163","doi-asserted-by":"publisher","first-page":"13325","DOI":"10.1073\/pnas.0700636104","volume":"104","author":"AM Malone","year":"2007","unstructured":"Malone AM et al (2007) Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci USA 104(33):13325\u201313330","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"12_CR164","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1242\/dev.024166","volume":"137","author":"T Mammoto","year":"2010","unstructured":"Mammoto T, Ingber DE (2010) Mechanical control of tissue and organ development. Development 137(9):1407\u20131420. https:\/\/doi.org\/10.1242\/dev.024166.\/p","journal-title":"Development"},{"issue":"1","key":"12_CR165","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41526-022-00194-8","volume":"8","author":"J Man","year":"2022","unstructured":"Man J et al (2022) The effects of microgravity on bone structure and function. NPJ Microgravity 8(1):9","journal-title":"NPJ Microgravity"},{"issue":"10","key":"12_CR166","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1007\/s13238-019-0614-3","volume":"10","author":"H Mao","year":"2019","unstructured":"Mao H et al (2019) Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1. Protein Cell 10(10):726\u2013744","journal-title":"Protein Cell"},{"issue":"4","key":"12_CR321","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/s44222-023-00144-3","volume":"2","author":"S Mascharak","year":"2024","unstructured":"Mascharak S et al (2024) Modelling and targeting mechanical forces in organ fibrosis. Nat Rev Bioeng 2(4):305\u2013323. https:\/\/doi.org\/10.1038\/s44222-023-00144-3","journal-title":"Nat Rev Bioeng"},{"issue":"7","key":"12_CR167","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/S0165-6147(00)01678-3","volume":"22","author":"MJ Marinissen","year":"2001","unstructured":"Marinissen MJ, Gutkind JS (2001) G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 22(7):368\u2013376","journal-title":"Trends Pharmacol Sci"},{"key":"12_CR355","doi-asserted-by":"publisher","unstructured":"Marshall WF, Rosenbaum JL (1999) Cell division: the renaissance of the centriole. Curr Biol 9(6):R218\u2013R220. https:\/\/doi.org\/10.1016\/s0960-9822(99)80133-x.\/pp44","DOI":"10.1016\/s0960-9822(99)80133-x.\/pp44"},{"issue":"3","key":"12_CR168","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cmet.2008.08.002","volume":"8","author":"R Masuyama","year":"2008","unstructured":"Masuyama R et al (2008) TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab 8(3):257\u2013265","journal-title":"Cell Metab"},{"issue":"3","key":"12_CR169","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1053\/j.gastro.2006.07.003","volume":"131","author":"AI Masyuk","year":"2006","unstructured":"Masyuk AI et al (2006) Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology 131(3):911\u2013920","journal-title":"Gastroenterology"},{"issue":"7","key":"12_CR170","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1002\/jbmr.2439","volume":"30","author":"M Maycas","year":"2015","unstructured":"Maycas M et al (2015) Role of the parathyroid hormone type 1 receptor (PTH1R) as a mechanosensor in osteocyte survival. J Bone Miner Res 30(7):1231\u20131244","journal-title":"J Bone Miner Res"},{"issue":"1","key":"12_CR171","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2046-2530-1-7","volume":"1","author":"HL May-Simera","year":"2012","unstructured":"May-Simera HL, Kelley MW (2012) Cilia, Wnt signaling, and the cytoskeleton. Cilia 1(1):7","journal-title":"Cilia"},{"issue":"9","key":"12_CR172","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1369\/jhc.5A6866.2006","volume":"54","author":"SR McGlashan","year":"2006","unstructured":"McGlashan SR, Jensen CG, Poole CA (2006) Localization of extracellular matrix receptors on the chondrocyte primary cilium. J Histochem Cytochem 54(9):1005\u20131014","journal-title":"J Histochem Cytochem"},{"issue":"8","key":"12_CR173","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1002\/dvdy.21501","volume":"237","author":"SR McGlashan","year":"2008","unstructured":"McGlashan SR et al (2008) Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters. Dev Dyn 237(8):2013\u20132020. https:\/\/doi.org\/10.1002\/dvdy.21501.\/p","journal-title":"Dev Dyn"},{"issue":"5","key":"12_CR174","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1042\/CBI20090094","volume":"34","author":"SR McGlashan","year":"2010","unstructured":"McGlashan SR et al (2010) Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biol Int 34(5):441\u2013446","journal-title":"Cell Biol Int"},{"issue":"3","key":"12_CR175","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ajhg.2013.06.022","volume":"93","author":"AM McInerney-Leo","year":"2013","unstructured":"McInerney-Leo AM et al (2013) Short-rib polydactyly and Jeune syndromes are caused by mutations in WDR60. Am J Hum Genet 93(3):515\u2013523","journal-title":"Am J Hum Genet"},{"key":"12_CR176","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/TCRM.S338653","volume":"19","author":"A Melluso","year":"2023","unstructured":"Melluso A et al (2023) Bardet-Biedl syndrome: current perspectives and clinical outlook. Ther Clin Risk Manag 19:115\u2013132","journal-title":"Ther Clin Risk Manag"},{"issue":"1","key":"12_CR177","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/hmg\/ddy322","volume":"28","author":"D Merrick","year":"2019","unstructured":"Merrick D et al (2019) Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZ. Hum Mol Genet 28(1):16\u201330","journal-title":"Hum Mol Genet"},{"issue":"7","key":"12_CR178","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41576-023-00587-9","volume":"24","author":"P Mill","year":"2023","unstructured":"Mill P, Christensen ST, Pedersen LB (2023) Primary cilia as dynamic and diverse signalling hubs in development and disease. Nat Rev Genet 24(7):421\u2013441. https:\/\/doi.org\/10.1038\/s41576-023-00587-9","journal-title":"Nat Rev Genet"},{"issue":"8","key":"12_CR179","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003746","volume":"9","author":"KA Miller","year":"2013","unstructured":"Miller KA et al (2013) Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome. PLoS Genet 9(8):e1003746","journal-title":"PLoS Genet"},{"issue":"4","key":"12_CR180","doi-asserted-by":"publisher","first-page":"E83","DOI":"10.1038\/ncb0402-e83","volume":"4","author":"CK Miranti","year":"2002","unstructured":"Miranti CK, Brugge JS (2002) Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 4(4):E83\u2013E90","journal-title":"Nat Cell Biol"},{"issue":"2","key":"12_CR181","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/path.4843","volume":"241","author":"HM Mitchison","year":"2017","unstructured":"Mitchison HM, Valente EM (2017) Motile and non-motile cilia in human pathology: from function to phenotypes. J Pathol 241(2):294\u2013309. https:\/\/doi.org\/10.1002\/path.4843.\/p","journal-title":"J Pathol"},{"key":"12_CR328","doi-asserted-by":"publisher","unstructured":"Mishina Y, Snider TN (2014) Neural crest cell signaling pathways critical to cranial bone development and pathology. Exp Cell Res 325(2):138\u2013147. https:\/\/doi.org\/10.1016\/j.yexcr.2014.01.019.\/p","DOI":"10.1016\/j.yexcr.2014.01.019.\/p"},{"issue":"1","key":"12_CR182","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/jcp.21374","volume":"216","author":"F Mizoguchi","year":"2008","unstructured":"Mizoguchi F et al (2008) Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss. J Cell Physiol 216(1):47\u201353","journal-title":"J Cell Physiol"},{"key":"12_CR360","doi-asserted-by":"publisher","unstructured":"Molla-Herman A et al (2010) The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia. J Cell Sci 123(10):1785\u20131795. https:\/\/doi.org\/10.1242\/jcs.059519","DOI":"10.1242\/jcs.059519"},{"issue":"23","key":"12_CR184","doi-asserted-by":"publisher","first-page":"12648","DOI":"10.3390\/ijms252312648","volume":"25","author":"ER Moore","year":"2024","unstructured":"Moore ER, Konermann A (2024) Investigating the role of primary cilia and bone morphogenetic protein signaling in periodontal ligament response to orthodontic strain in vivo and in vitro: a pilot study. Int J Mol Sci 25(23):12648","journal-title":"Int J Mol Sci"},{"issue":"1","key":"12_CR185","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s13287-018-0930-1","volume":"9","author":"ER Moore","year":"2018","unstructured":"Moore ER et al (2018) Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation. Stem Cell Res Ther 9(1):190","journal-title":"Stem Cell Res Ther"},{"issue":"9","key":"12_CR186","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1359\/jbmr.2003.18.9.1706","volume":"18","author":"M Morinobu","year":"2009","unstructured":"Morinobu M et al (2009) Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo. J Bone Miner Res 18(9):1706\u20131715","journal-title":"J Bone Miner Res"},{"issue":"5","key":"12_CR187","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00439-010-0804-9","volume":"127","author":"J Muller","year":"2010","unstructured":"Muller J et al (2010) Identification of 28 novel mutations in the Bardet-Biedl syndrome genes: the burden of private mutations in an extensively heterogeneous disease. Hum Genet 127(5):583\u2013593","journal-title":"Hum Genet"},{"key":"12_CR333","doi-asserted-by":"publisher","unstructured":"Mizoguchi T, Ono N (2021) The diverse origin of bone-forming osteoblasts. J Bone Miner Res 36(8):1432\u20131447. https:\/\/doi.org\/10.1002\/jbmr.4410.\/p","DOI":"10.1002\/jbmr.4410.\/p"},{"issue":"8","key":"12_CR188","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183030","volume":"12","author":"T Nagai","year":"2017","unstructured":"Nagai T, Mizuno K (2017) Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation. PLoS One 12(8):e0183030","journal-title":"PLoS One"},{"key":"12_CR339","doi-asserted-by":"publisher","unstructured":"Nakashima T, Takayanagi H (2011) New regulation mechanisms of osteoclast differentiation. Ann N Y Acad Sci 1240:E13\u2013E18. https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06373.x.\/pp25","DOI":"10.1111\/j.1749-6632.2011.06373.x.\/pp25"},{"issue":"2","key":"12_CR189","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/ng1076","volume":"33","author":"SM Nauli","year":"2003","unstructured":"Nauli SM et al (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33(2):129\u2013137","journal-title":"Nat Genet"},{"issue":"9","key":"12_CR190","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1161\/CIRCULATIONAHA.107.710111","volume":"117","author":"SM Nauli","year":"2008","unstructured":"Nauli SM et al (2008) Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 117(9):1161\u20131171","journal-title":"Circulation"},{"key":"12_CR326","doi-asserted-by":"publisher","unstructured":"Noden DM, Trainor PA (2005) Relations and interactions between cranial mesoderm and neural crest populations. J Anat 207(5):575\u2013601. https:\/\/doi.org\/10.1111\/j.1469-7580.2005.00473.x.\/pp12","DOI":"10.1111\/j.1469-7580.2005.00473.x.\/pp12"},{"key":"12_CR327","doi-asserted-by":"publisher","unstructured":"Neben CL, Merrill AE (2015) Signaling pathways in craniofacial development: insights from rare skeletal disorders. Curr Top Dev Biol 115:493\u2013542. https:\/\/doi.org\/10.1016\/bs.ctdb.2015.09.005.\/pp13","DOI":"10.1016\/bs.ctdb.2015.09.005.\/pp13"},{"issue":"2","key":"12_CR191","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bone.2012.11.016","volume":"54","author":"AM Nguyen","year":"2013","unstructured":"Nguyen AM, Jacobs CR (2013) Emerging role of primary cilia as mechanosensors in osteocytes. Bone 54(2):196\u2013204. https:\/\/doi.org\/10.1016\/j.bone.2012.11.016.\/pp39","journal-title":"Bone"},{"issue":"11","key":"12_CR192","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1002\/humu.23862","volume":"40","author":"V Niederlova","year":"2019","unstructured":"Niederlova V et al (2019) Meta-analysis of genotype-phenotype associations in Bardet-Biedl syndrome uncovers differences among causative genes. Hum Mutat 40(11):2068\u20132087","journal-title":"Hum Mutat"},{"issue":"1","key":"12_CR193","doi-asserted-by":"publisher","first-page":"1801138","DOI":"10.1002\/advs.201801138","volume":"6","author":"Y Nishimura","year":"2019","unstructured":"Nishimura Y et al (2019) Primary cilia as signaling hubs in health and disease. Adv Sci 6(1):1801138","journal-title":"Adv Sci"},{"issue":"19","key":"12_CR194","doi-asserted-by":"publisher","first-page":"E2589","DOI":"10.1073\/pnas.1519458113","volume":"113","author":"K Noda","year":"2016","unstructured":"Noda K et al (2016) Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. Proc Natl Acad Sci 113(19):E2589\u2013E2597","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"12_CR195","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s43856-025-00975-8","volume":"5","author":"R Novak","year":"2025","unstructured":"Novak R et al (2025) AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett syndrome in preclinical models. Commun Med 5(1):249","journal-title":"Commun Med"},{"issue":"1","key":"12_CR196","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0092-8674(82)90409-3","volume":"31","author":"R Nusse","year":"1982","unstructured":"Nusse R, Varmus HE (1982) Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31(1):99\u2013109","journal-title":"Cell"},{"key":"12_CR358","doi-asserted-by":"publisher","unstructured":"Ocbina PJ, Tuson M, Anderson KV (2009) Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. PLoS One 4(8):e6839. https:\/\/doi.org\/10.1371\/journal.pone.0006839","DOI":"10.1371\/journal.pone.0006839"},{"issue":"1","key":"12_CR197","doi-asserted-by":"publisher","first-page":"44260","DOI":"10.1038\/srep44260","volume":"7","author":"N Oliazadeh","year":"2017","unstructured":"Oliazadeh N et al (2017) Identification of elongated primary cilia with impaired mechanotransduction in idiopathic scoliosis patients. Sci Rep 7(1):44260","journal-title":"Sci Rep"},{"issue":"1","key":"12_CR198","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1038\/s41598-022-05918-0","volume":"12","author":"N Oliazadeh","year":"2022","unstructured":"Oliazadeh N et al (2022) Altered mechanotransduction in adolescent idiopathic scoliosis osteoblasts: an exploratory in vitro study. Sci Rep 12(1):1846","journal-title":"Sci Rep"},{"issue":"2","key":"12_CR199","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.devcel.2008.12.003","volume":"16","author":"LE Olson","year":"2009","unstructured":"Olson LE, Soriano P (2009) Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16(2):303\u2013313","journal-title":"Dev Cell"},{"issue":"1","key":"12_CR200","doi-asserted-by":"publisher","first-page":"5312","DOI":"10.1038\/s41467-020-19063-7","volume":"11","author":"T Ong","year":"2020","unstructured":"Ong T et al (2020) Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy. Nat Commun 11(1):5312. https:\/\/doi.org\/10.1038\/s41467-020-19063-7.\/pp207","journal-title":"Nat Commun"},{"key":"12_CR338","doi-asserted-by":"publisher","unstructured":"Ornitz DM, Marie PJ (2015) Fibroblast growth factor signaling in skeletal development and disease. Genes Dev 29(14):1463\u20131486. https:\/\/doi.org\/10.1101\/gad.266551.115","DOI":"10.1101\/gad.266551.115"},{"key":"12_CR329","doi-asserted-by":"publisher","unstructured":"Ozcivici E et al (2010) Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol 6(1):50\u201359. https:\/\/doi.org\/10.1038\/nrrheum.2009.239.\/pp16","DOI":"10.1038\/nrrheum.2009.239.\/pp16"},{"key":"12_CR201","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-1-4614-6255-2_2","volume-title":"Design of Artificial Human Joints & Organs","author":"S Pal","year":"2014","unstructured":"Pal S (2014) Mechanical properties of biological materials. In: Pal S (ed) Design of Artificial Human Joints & Organs. Springer US, Boston, MA, pp 23\u201340"},{"key":"12_CR202","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114491","volume":"161","author":"P Pandey","year":"2023","unstructured":"Pandey P et al (2023) New insights about the PDGF\/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies. Biomed Pharmacother 161:114491","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"12_CR203","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1136\/jmg.2005.036608","volume":"43","author":"MA Parisi","year":"2006","unstructured":"Parisi MA et al (2006) AHI1 mutations cause both retinal dystrophy and renal cystic disease in Joubert syndrome. J Med Genet 43(4):334\u2013339","journal-title":"J Med Genet"},{"key":"12_CR344","doi-asserted-by":"publisher","unstructured":"Pazour GJ, Rosenbaum JL (2002) Intraflagellar transport and cilia-dependent diseases. Trends Cell Biol 12(12):551\u2013555. https:\/\/doi.org\/10.1016\/s0962-8924(02)02410-8.\/pp30","DOI":"10.1016\/s0962-8924(02)02410-8.\/pp30"},{"issue":"5","key":"12_CR204","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.ajhg.2012.03.006","volume":"90","author":"I Perrault","year":"2012","unstructured":"Perrault I et al (2012) Mainzer-Saldino syndrome is a ciliopathy caused by IFT140 mutations. Am J Hum Genet 90(5):864\u2013870","journal-title":"Am J Hum Genet"},{"issue":"1","key":"12_CR205","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1083\/jcb.200905103","volume":"187","author":"G Pigino","year":"2009","unstructured":"Pigino G et al (2009) Electron-tomographic analysis of intraflagellar transport particle trains in situ. J Cell Biol 187(1):135\u2013148","journal-title":"J Cell Biol"},{"key":"12_CR363","doi-asserted-by":"publisher","unstructured":"Pittman AE, Solecki DJ (2023) Cooperation between primary cilia signaling and integrin receptor extracellular matrix engagement regulates progenitor proliferationand neuronal differentiation in the developing cerebellum. Front Cell Dev Biol 11:1127638. https:\/\/doi.org\/10.3389\/fcell.2023.1127638.\/p","DOI":"10.3389\/fcell.2023.1127638.\/p"},{"key":"12_CR206","first-page":"137","volume-title":"Methods in cell biology","author":"OV Plotnikova","year":"2009","unstructured":"Plotnikova OV, Pugacheva EN, Golemis EA (2009) Chapter 7 \u2013 Primary cilia and the cell cycle. In: Sloboda RD (ed) Methods in cell biology. Academic Press, pp 137\u2013160"},{"issue":"1","key":"12_CR207","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00232-001-0075-4","volume":"184","author":"HA Praetorius","year":"2001","unstructured":"Praetorius HA, Spring KR (2001) Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 184(1):71\u201379","journal-title":"J Membr Biol"},{"key":"12_CR208","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jot.2022.03.008","volume":"34","author":"L Qin","year":"2022","unstructured":"Qin L et al (2022) Osteocyte \u03b21 integrin loss causes low bone mass and impairs bone mechanotransduction in mice. J Orthop Translat 34:60\u201372","journal-title":"J Orthop Translat"},{"key":"12_CR209","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jot.2023.05.001","volume":"40","author":"L Qin","year":"2023","unstructured":"Qin L et al (2023) Osteocyte \u03b23 integrin promotes bone mass accrual and force-induced bone formation in mice. J Orthop Translat 40:58\u201371","journal-title":"J Orthop Translat"},{"issue":"Pt 8","key":"12_CR210","first-page":"1945","volume":"125","author":"N Qiu","year":"2012","unstructured":"Qiu N et al (2012) Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia. J Cell Sci 125(Pt 8):1945\u20131957","journal-title":"J Cell Sci"},{"issue":"1","key":"12_CR211","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2023.113751","volume":"431","author":"N Quadri","year":"2023","unstructured":"Quadri N, Upadhyai P (2023) Primary cilia in skeletal development and disease. Exp Cell Res 431(1):113751","journal-title":"Exp Cell Res"},{"issue":"5","key":"12_CR212","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1083\/jcb.200503053","volume":"169","author":"LM Quarmby","year":"2005","unstructured":"Quarmby LM, Parker JDK (2005) Cilia and the cell cycle? J Cell Biol 169(5):707\u2013710","journal-title":"J Cell Biol"},{"key":"12_CR340","doi-asserted-by":"publisher","unstructured":"Rauner M, Bozec A (2026) Mechanisms of osteoclast activation in inflammatory bone loss in rheumatoid arthritis. Nat Rev Rheumatol 22(1):42\u2013461. https:\/\/doi.org\/10.1038\/s41584-025-01323-9.\/pp26","DOI":"10.1038\/s41584-025-01323-9.\/pp26"},{"issue":"12","key":"12_CR213","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1113\/jphysiol.2014.271346","volume":"592","author":"K Retailleau","year":"2014","unstructured":"Retailleau K, Duprat F (2014) Polycystins and partners: proposed role in mechanosensitivity. J Physiol 592(12):2453\u20132471","journal-title":"J Physiol"},{"issue":"4","key":"12_CR214","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1152\/jappl.2001.90.4.1385","volume":"90","author":"SR Roberts","year":"2001","unstructured":"Roberts SR et al (2001) Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs. J Appl Physiol (1985) 90(4):1385\u20131391","journal-title":"J Appl Physiol (1985)"},{"issue":"8","key":"12_CR215","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1038\/ng.166","volume":"40","author":"MJ Rock","year":"2008","unstructured":"Rock MJ et al (2008) Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet 40(8):999\u20131003","journal-title":"Nat Genet"},{"issue":"5836","key":"12_CR216","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1126\/science.1139740","volume":"317","author":"R Rohatgi","year":"2007","unstructured":"Rohatgi R, Milenkovic L, Scott MP (2007) Patched1 regulates hedgehog signaling at the primary cilium. Science 317(5836):372\u2013376","journal-title":"Science"},{"key":"12_CR217","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/1750-1172-9-72","volume":"9","author":"M Romani","year":"2014","unstructured":"Romani M et al (2014) Mutations in B9D1 and MKS1 cause mild Joubert syndrome: expanding the genetic overlap with the lethal ciliopathy Meckel syndrome. Orphanet J Rare Dis 9:72","journal-title":"Orphanet J Rare Dis"},{"key":"12_CR345","doi-asserted-by":"publisher","unstructured":"Rosenbaum JL, Witman GB (2002) Intraflagellar transport. Nat Rev Mol Cell Biol 3(11):813\u2013825. https:\/\/doi.org\/10.1038\/nrm952.\/p","DOI":"10.1038\/nrm952.\/p"},{"key":"12_CR366","doi-asserted-by":"publisher","unstructured":"Ruhlen R, Marberry K (2014) The chondrocyte primary cilium. Osteoarthritis Cartilage 22(8):1071\u20131076. https:\/\/doi.org\/10.1016\/j.joca.2014.05.011.\/p","DOI":"10.1016\/j.joca.2014.05.011.\/p"},{"issue":"3","key":"12_CR218","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/73508","volume":"24","author":"VL Ruiz-Perez","year":"2000","unstructured":"Ruiz-Perez VL et al (2000) Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. Nat Genet 24(3):283\u2013286","journal-title":"Nat Genet"},{"issue":"6","key":"12_CR219","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1002\/jbmr.4506","volume":"37","author":"D Rux","year":"2022","unstructured":"Rux D et al (2022) Primary cilia direct murine articular cartilage tidemark patterning through hedgehog signaling and ambulatory load. J Bone Miner Res 37(6):1097\u20131116. https:\/\/doi.org\/10.1002\/jbmr.4506.\/pp34","journal-title":"J Bone Miner Res"},{"issue":"2","key":"12_CR220","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.tibs.2005.12.004","volume":"31","author":"PE Ryan","year":"2006","unstructured":"Ryan PE et al (2006) Regulating the regulator: negative regulation of Cbl ubiquitin ligases. Trends Biochem Sci 31(2):79\u201388","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"12_CR221","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/hmg\/ddx396","volume":"27","author":"R Ryan","year":"2018","unstructured":"Ryan R et al (2018) Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies. Hum Mol Genet 27(2):266\u2013282","journal-title":"Hum Mol Genet"},{"issue":"1","key":"12_CR222","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13075-023-03006-w","volume":"25","author":"LA Salman","year":"2023","unstructured":"Salman LA et al (2023) Osteoarthritis: a narrative review of molecular approaches to disease management. Arthritis Res Ther 25(1):27","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"12_CR223","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1136\/jmg.35.6.497","volume":"35","author":"R Salonen","year":"1998","unstructured":"Salonen R, Paavola P (1998) Meckel syndrome. J Med Genet 35(6):497\u2013501","journal-title":"J Med Genet"},{"key":"12_CR224","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1146\/annurev.physiol.69.040705.141236","volume":"69","author":"P Satir","year":"2007","unstructured":"Satir P, Christensen ST (2007) Overview of structure and function of mammalian cilia. Annu Rev Physiol 69:377\u2013400. https:\/\/doi.org\/10.1146\/annurev.physiol.69.040705.141236.\/p","journal-title":"Ann Rev Physiol"},{"issue":"1","key":"12_CR225","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1083\/jcb.201611050","volume":"217","author":"FM Schmid","year":"2017","unstructured":"Schmid FM et al (2017) IFT20 modulates ciliary PDGFR\u03b1 signaling by regulating the stability of Cbl E3 ubiquitin ligases. J Cell Biol 217(1):151\u2013161","journal-title":"J Cell Biol"},{"issue":"5","key":"12_CR226","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.ajhg.2013.10.003","volume":"93","author":"M Schmidts","year":"2013","unstructured":"Schmidts M et al (2013a) Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy. Am J Hum Genet 93(5):932\u2013944","journal-title":"Am J Hum Genet"},{"issue":"5","key":"12_CR227","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1136\/jmedgenet-2012-101284","volume":"50","author":"M Schmidts","year":"2013","unstructured":"Schmidts M et al (2013b) Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvement. J Med Genet 50(5):309\u2013323","journal-title":"J Med Genet"},{"issue":"20","key":"12_CR228","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1016\/j.cub.2005.09.012","volume":"15","author":"L Schneider","year":"2005","unstructured":"Schneider L et al (2005) PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol 15(20):1861\u20131866","journal-title":"Curr Biol"},{"issue":"9","key":"12_CR229","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.15252\/embr.201540530","volume":"16","author":"KB Schou","year":"2015","unstructured":"Schou KB, Pedersen LB, Christensen ST (2015) Ins and outs of GPCR signaling in primary cilia. EMBO Rep 16(9):1099\u20131113","journal-title":"EMBO Rep"},{"key":"12_CR348","doi-asserted-by":"publisher","unstructured":"Schock EN, Brugmann SA (2017) Discovery, diagnosis, and etiology of craniofacial ciliopathies. Cold Spring Harb Perspect Biol 9(9). https:\/\/doi.org\/10.1101\/cshperspect.a028258.\/pp36","DOI":"10.1101\/cshperspect.a028258.\/pp36"},{"issue":"12","key":"12_CR230","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005066","volume":"2","author":"MA Schwartz","year":"2010","unstructured":"Schwartz MA (2010) Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol 2(12):a005066","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"4","key":"12_CR231","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.ajhg.2019.02.018","volume":"104","author":"R Shaheen","year":"2019","unstructured":"Shaheen R et al (2019) Bi-allelic mutations in FAM149B1 cause abnormal primary cilium and a range of ciliopathy phenotypes in humans. Am J Hum Genet 104(4):731\u2013737","journal-title":"Am J Hum Genet"},{"issue":"1","key":"12_CR232","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/ahg.12534","volume":"88","author":"WM Shaikh Qureshi","year":"2024","unstructured":"Shaikh Qureshi WM, Hentges KE (2024) Functions of cilia in cardiac development and disease. Ann Hum Genet 88(1):4\u201326","journal-title":"Ann Hum Genet"},{"issue":"12","key":"12_CR233","first-page":"91","volume":"2","author":"RT Sherpa","year":"2016","unstructured":"Sherpa RT et al (2016) Rapamycin increases length and mechanosensory function of primary cilia in renal epithelial and vascular endothelial cells. Int Educ Res J 2(12):91\u201397","journal-title":"Int Educ Res J"},{"issue":"2","key":"12_CR234","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.tjog.2022.02.018","volume":"61","author":"S-Y Sheu","year":"2022","unstructured":"Sheu S-Y et al (2022) Platelet-derived growth factor-AA promotes placental choriocarcinoma JAR cell proliferation via primary cilia. Taiwan J Obstet Gynecol 61(2):299\u2013305","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"1","key":"12_CR235","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1038\/s41598-017-02049-9","volume":"7","author":"W Shi","year":"2017","unstructured":"Shi W et al (2017) Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia. Sci Rep 7(1):1866","journal-title":"Sci Rep"},{"key":"12_CR236","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115346","volume":"136","author":"W Shi","year":"2020","unstructured":"Shi W et al (2020) Primary cilia act as microgravity sensors by depolymerizing microtubules to inhibit osteoblastic differentiation and mineralization. Bone 136:115346","journal-title":"Bone"},{"issue":"7","key":"12_CR237","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.molmed.2023.04.001","volume":"29","author":"DF Silva","year":"2023","unstructured":"Silva DF, Cavadas C (2023) Primary cilia shape hallmarks of health and aging. Trends Mol Med 29(7):567\u2013579","journal-title":"Trends Mol Med"},{"issue":"5787","key":"12_CR238","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1126\/science.1124534","volume":"313","author":"V Singla","year":"2006","unstructured":"Singla V, Reiter JF (2006) The primary cilium as the cell\u2019s antenna: signaling at a sensory organelle. Science 313(5787):629\u2013633","journal-title":"Science"},{"issue":"1","key":"12_CR239","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/bies.950190109","volume":"19","author":"MD Sjaastad","year":"1997","unstructured":"Sjaastad MD, Nelson WJ (1997) Integrin-mediated calcium signaling and regulation of cell adhesion by intracellular calcium. BioEssays 19(1):47\u201355","journal-title":"BioEssays"},{"issue":"2","key":"12_CR240","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/ng1713","volume":"38","author":"UM Smith","year":"2006","unstructured":"Smith UM et al (2006) The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat. Nat Genet 38(2):191\u2013196","journal-title":"Nat Genet"},{"issue":"1","key":"12_CR241","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ydbio.2007.02.003","volume":"305","author":"B Song","year":"2007","unstructured":"Song B et al (2007) Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol 305(1):202\u2013216","journal-title":"Dev Biol"},{"issue":"14","key":"12_CR242","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1242\/dev.124.14.2691","volume":"124","author":"P Soriano","year":"1997","unstructured":"Soriano P (1997) The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 124(14):2691\u20132700","journal-title":"Development"},{"issue":"2","key":"12_CR243","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1083\/jcb.15.2.363","volume":"15","author":"S Sorokin","year":"1962","unstructured":"Sorokin S (1962) Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells. J Cell Biol 15(2):363\u2013377. https:\/\/doi.org\/10.1083\/jcb.15.2.363.\/pp47","journal-title":"J Cell Biol"},{"issue":"3","key":"12_CR244","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0749-0690(02)00022-8","volume":"18","author":"M Srivastava","year":"2002","unstructured":"Srivastava M, Deal C (2002) Osteoporosis in elderly: prevention and treatment. Clin Geriatr Med 18(3):529\u2013555","journal-title":"Clin Geriatr Med"},{"issue":"2","key":"12_CR245","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2023.100357","volume":"5","author":"LB Stam","year":"2023","unstructured":"Stam LB, Clark AL (2023) Chondrocyte primary cilia lengthening and shortening in response to mediators of osteoarthritis; a role for integrin \u03b11\u03b21 and focal adhesions. Osteoarthr Cartil Open 5(2):100357","journal-title":"Osteoarthr Cartil Open"},{"issue":"8","key":"12_CR246","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1002\/ajmg.a.62337","volume":"185","author":"A Strong","year":"2021","unstructured":"Strong A et al (2021) Expanding the genetic landscape of oral-facial-digital syndrome with two novel genes. Am J Med Genet A 185(8):2409\u20132416","journal-title":"Am J Med Genet A"},{"key":"12_CR247","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47454","volume":"8","author":"W Sun","year":"2019","unstructured":"Sun W et al (2019) The mechanosensitive Piezo1 channel is required for bone formation. elife 8:e47454","journal-title":"elife"},{"key":"12_CR248","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.112141","volume":"136","author":"Y Sun","year":"2025","unstructured":"Sun Y et al (2025) Primary cilia integrity governs TRPV4-mediated NF-\u03baB\/COL2 signaling in osteoarthritis pathogenesis. Cell Signal 136:112141","journal-title":"Cell Signal"},{"key":"12_CR249","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109649","volume":"72","author":"CR Sussman","year":"2020","unstructured":"Sussman CR et al (2020) Modulation of polycystic kidney disease by G-protein coupled receptors and cyclic AMP signaling. Cell Signal 72:109649","journal-title":"Cell Signal"},{"issue":"5","key":"12_CR250","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/gb-2007-8-5-215","volume":"8","author":"Y Takada","year":"2007","unstructured":"Takada Y, Ye X, Simon S (2007) The integrins. Genome Biol 8(5):215","journal-title":"Genome Biol"},{"key":"12_CR342","doi-asserted-by":"publisher","unstructured":"Takahashi N et al (1988) Osteoblastic cells are involved in osteoclast formation. Endocrinology 123(5):2600\u20132602. https:\/\/doi.org\/10.1210\/endo-123-5-2600.\/pp28","DOI":"10.1210\/endo-123-5-2600.\/pp28"},{"key":"12_CR343","doi-asserted-by":"publisher","unstructured":"Takayanagi H (2007) Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7(4):292\u2013304. https:\/\/doi.org\/10.1038\/nri2062.\/p","DOI":"10.1038\/nri2062.\/p"},{"issue":"3","key":"12_CR251","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1093\/hmg\/ddx421","volume":"27","author":"M Takahara","year":"2018","unstructured":"Takahara M et al (2018) Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis. Hum Mol Genet 27(3):516\u2013528","journal-title":"Hum Mol Genet"},{"issue":"6","key":"12_CR252","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.ajhg.2008.05.004","volume":"82","author":"J Tallila","year":"2008","unstructured":"Tallila J et al (2008) Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle. Am J Hum Genet 82(6):1361\u20131367","journal-title":"Am J Hum Genet"},{"issue":"1","key":"12_CR253","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41368-023-00223-6","volume":"15","author":"D Tao","year":"2023","unstructured":"Tao D et al (2023) Primary cilia support cartilage regeneration after injury. Int J Oral Sci 15(1):22","journal-title":"Int J Oral Sci"},{"issue":"1","key":"12_CR254","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/j.1749-6632.2009.05243.x","volume":"1192","author":"S Temiyasathit","year":"2010","unstructured":"Temiyasathit S, Jacobs CR (2010) Osteocyte primary cilium and its role in bone mechanotransduction. Ann N Y Acad Sci 1192(1):422\u2013428","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"12_CR255","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033368","volume":"7","author":"S Temiyasathit","year":"2012","unstructured":"Temiyasathit S et al (2012) Mechanosensing by the primary cilium: deletion of Kif3A reduces bone formation due to loading. PLoS One 7(3):e33368","journal-title":"PLoS One"},{"issue":"1","key":"12_CR256","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/cm.21271","volume":"73","author":"ME Teves","year":"2016","unstructured":"Teves ME et al (2016) Mammalian axoneme central pair complex proteins: broader roles revealed by gene knockout phenotypes. Cytoskeleton 73(1):3\u201322","journal-title":"Cytoskeleton"},{"issue":"2","key":"12_CR257","doi-asserted-by":"publisher","first-page":"E320","DOI":"10.1002\/humu.20888","volume":"30","author":"C Thauvin-Robinet","year":"2009","unstructured":"Thauvin-Robinet C et al (2009) Genomic deletions of OFD1 account for 23% of oral-facial-digital type 1 syndrome after negative DNA sequencing. Hum Mutat 30(2):E320\u2013E329","journal-title":"Hum Mutat"},{"issue":"8","key":"12_CR258","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/ng.3031","volume":"46","author":"C Thauvin-Robinet","year":"2014","unstructured":"Thauvin-Robinet C et al (2014) The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nat Genet 46(8):905\u2013911","journal-title":"Nat Genet"},{"issue":"9","key":"12_CR259","doi-asserted-by":"publisher","first-page":"4313","DOI":"10.3390\/ijms22094313","volume":"22","author":"CL Thompson","year":"2021","unstructured":"Thompson CL et al (2021) Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation. Int J Mol Sci 22(9):4313","journal-title":"Int J Mol Sci"},{"key":"12_CR260","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107887","volume":"219","author":"H Ti","year":"2025","unstructured":"Ti H et al (2025) Primary cilia as mechanosensors in musculoskeletal homeostasis and disease. Pharmacol Res 219:107887. https:\/\/doi.org\/10.1016\/j.phrs.2025.107887.\/p","journal-title":"Pharmacol Res"},{"issue":"7","key":"12_CR261","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.3390\/genes12071073","volume":"12","author":"F Tiberio","year":"2021","unstructured":"Tiberio F, Parolini O, Lattanzi W (2021) Ciliary signalling and mechanotransduction in the pathophysiology of craniosynostosis. Genes 12(7):1073","journal-title":"Genes"},{"issue":"10","key":"12_CR262","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1002\/jcp.30849","volume":"237","author":"I Tirado-Cabrera","year":"2022","unstructured":"Tirado-Cabrera I et al (2022) PTH1R translocation to primary cilia in mechanically-stimulated osteocytes prevents osteoclast formation via regulation of CXCL5 and IL-6 secretion. J Cell Physiol 237(10):3927\u20133943","journal-title":"J Cell Physiol"},{"issue":"10","key":"12_CR263","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/ejhg.2012.305","volume":"21","author":"L Travaglini","year":"2013","unstructured":"Travaglini L et al (2013) Phenotypic spectrum and prevalence of INPP5E mutations in Joubert syndrome and related disorders. Eur J Hum Genet 21(10):1074\u20131078","journal-title":"Eur J Hum Genet"},{"issue":"4","key":"12_CR264","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s11914-017-0373-0","volume":"15","author":"Y Uda","year":"2017","unstructured":"Uda Y et al (2017) Osteocyte mechanobiology. Curr Osteoporos Rep 15(4):318\u2013325","journal-title":"Curr Osteoporos Rep"},{"key":"12_CR336","doi-asserted-by":"publisher","unstructured":"Unlu G et al (2014) Trafficking mechanisms of extracellular matrix macromolecules: insights from vertebrate development and human diseases. Int J Biochem Cell Biol 47:57\u201367. https:\/\/doi.org\/10.1016\/j.biocel.2013.11.005.\/p","DOI":"10.1016\/j.biocel.2013.11.005.\/p"},{"issue":"7","key":"12_CR265","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/ng.594","volume":"42","author":"EM Valente","year":"2010","unstructured":"Valente EM et al (2010) Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. Nat Genet 42(7):619\u2013625","journal-title":"Nat Genet"},{"issue":"23","key":"12_CR266","doi-asserted-by":"publisher","first-page":"13324","DOI":"10.1073\/pnas.231474698","volume":"98","author":"SJ Van Cromphaut","year":"2001","unstructured":"Van Cromphaut SJ et al (2001) Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci USA 98(23):13324\u201313329","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"12_CR267","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s10237-014-0631-3","volume":"14","author":"TJ Vaughan","year":"2015","unstructured":"Vaughan TJ et al (2015) Bone cell mechanosensation of fluid flow stimulation: a fluid-structure interaction model characterising the role integrin attachments and primary cilia. Biomech Model Mechanobiol 14(4):703\u2013718","journal-title":"Biomech Model Mechanobiol"},{"issue":"1","key":"12_CR268","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/jomfp.JOMFP_48_17","volume":"21","author":"D Venkatesh","year":"2017","unstructured":"Venkatesh D (2017) Primary cilia. J Oral Maxillofac Pathol 21(1):8\u201310","journal-title":"J Oral Maxillofac Pathol"},{"issue":"6","key":"12_CR269","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s11914-023-00819-1","volume":"21","author":"SW Verbruggen","year":"2023","unstructured":"Verbruggen SW, Sittichokechaiwut A, Reilly GC (2023) Osteocytes and primary cilia. Curr Osteoporos Rep 21(6):719\u2013730","journal-title":"Curr Osteoporos Rep"},{"issue":"8","key":"12_CR270","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/gim.2016.204","volume":"19","author":"T Vilboux","year":"2017","unstructured":"Vilboux T et al (2017) Molecular genetic findings and clinical correlations in 100 patients with Joubert syndrome and related disorders prospectively evaluated at a single center. Genet Med 19(8):875\u2013882","journal-title":"Genet Med"},{"issue":"8","key":"12_CR271","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.bbamcr.2017.05.005","volume":"1864","author":"AM Vlaikou","year":"2017","unstructured":"Vlaikou AM et al (2017) Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of hAT-MSCs. Biochim Biophys Acta, Mol Cell Res 1864(8):1371\u20131381","journal-title":"Biochim Biophys Acta, Mol Cell Res"},{"key":"12_CR272","first-page":"95","volume-title":"Current topics in developmental biology","author":"LT Vuong","year":"2023","unstructured":"Vuong LT, Mlodzik M (2023) Chapter Three \u2013 The complex relationship of Wnt-signaling pathways and cilia. In: Iomini C, Sun Y (eds) Current topics in developmental biology. Academic Press, New York, pp 95\u2013125"},{"issue":"6","key":"12_CR273","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.ajhg.2010.04.012","volume":"86","author":"J Walczak-Sztulpa","year":"2010","unstructured":"Walczak-Sztulpa J et al (2010) Cranioectodermal dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 gene. Am J Hum Genet 86(6):949\u2013956","journal-title":"Am J Hum Genet"},{"issue":"1","key":"12_CR274","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13023-020-1303-2","volume":"15","author":"J Walczak-Sztulpa","year":"2020","unstructured":"Walczak-Sztulpa J et al (2020) Compound heterozygous IFT140 variants in two Polish families with Sensenbrenner syndrome and early onset end-stage renal disease. Orphanet J Rare Dis 15(1):36","journal-title":"Orphanet J Rare Dis"},{"key":"12_CR275","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.931822","volume":"13","author":"J Walczak-Sztulpa","year":"2022","unstructured":"Walczak-Sztulpa J et al (2022) Identical IFT140 variants cause variable skeletal ciliopathy phenotypes-challenges for the accurate diagnosis. Front Genet 13:931822","journal-title":"Front Genet"},{"issue":"1","key":"12_CR276","doi-asserted-by":"publisher","first-page":"4072","DOI":"10.1038\/s41467-019-12067-y","volume":"10","author":"RV Walker","year":"2019","unstructured":"Walker RV et al (2019) Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model. Nat Commun 10(1):4072","journal-title":"Nat Commun"},{"issue":"1","key":"12_CR277","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","volume":"11","author":"L Wang","year":"2020","unstructured":"Wang L et al (2020) Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nat Commun 11(1):282","journal-title":"Nat Commun"},{"issue":"1","key":"12_CR278","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","volume":"10","author":"L Wang","year":"2022","unstructured":"Wang L et al (2022a) Mechanical regulation of bone remodeling. Bone Res 10(1):16. https:\/\/doi.org\/10.1038\/s41413-022-00190-4.\/pp15","journal-title":"Bone Res"},{"issue":"1","key":"12_CR279","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13172","volume":"55","author":"Q Wang","year":"2022","unstructured":"Wang Q et al (2022b) Substrate stiffness regulates the differentiation profile and functions of osteoclasts via cytoskeletal arrangement. Cell Prolif 55(1):e13172","journal-title":"Cell Prolif"},{"issue":"8","key":"12_CR280","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.2183","volume":"11","author":"J Wang","year":"2023","unstructured":"Wang J et al (2023) A homozygous EVC mutation in a prenatal fetus with Ellis-van Creveld syndrome. Mol Genet Genomic Med 11(8):e2183","journal-title":"Mol Genet Genomic Med"},{"issue":"17","key":"12_CR281","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1007\/s00018-012-0980-y","volume":"69","author":"AK Wann","year":"2012","unstructured":"Wann AK et al (2012) Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes. Faseb J 26(4):1663\u20131671. https:\/\/doi.org\/10.1096\/fj.11-193649","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"12_CR282","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1096\/fj.11-193649","volume":"26","author":"AK Wann","year":"2012","unstructured":"Wann AK et al (2012) Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes. FASEB J 26(4):1663\u20131671","journal-title":"FASEB J"},{"issue":"1","key":"12_CR283","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1006\/cbir.1996.0011","volume":"20","author":"DN Wheatley","year":"1996","unstructured":"Wheatley DN, Wang AM, Strugnell GE (1996) Expression of primary cilia in mammalian cells. Cell Biol Int 20(1):73\u201381","journal-title":"Cell Biol Int"},{"issue":"5","key":"12_CR320","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1172\/jci118293","volume":"96","author":"E Wilson","year":"1995","unstructured":"Wilson E, Sudhir K, Ives HE (1995) Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix\/integrin interactions. J Clin Invest 96(5):2364\u20132372. https:\/\/doi.org\/10.1172\/jci118293","journal-title":"J Clin Invest"},{"issue":"5","key":"12_CR284","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1177\/154405910808700509","volume":"87","author":"GE Wise","year":"2008","unstructured":"Wise GE, King GJ (2008) Mechanisms of tooth eruption and orthodontic tooth movement. J Dent Res 87(5):414\u2013434","journal-title":"J Dent Res"},{"key":"12_CR356","doi-asserted-by":"publisher","unstructured":"Wood CR, Rosenbaum JL (2015) Ciliary ectosomes: transmissions from the cell\u2019s antenna. Trends Cell Biol 25(5):276\u2013285. https:\/\/doi.org\/10.1016\/j.tcb.2014.12.008.\/pp46","DOI":"10.1016\/j.tcb.2014.12.008.\/pp46"},{"issue":"34","key":"12_CR285","doi-asserted-by":"publisher","first-page":"13644","DOI":"10.1073\/pnas.1207170109","volume":"109","author":"VM Wu","year":"2012","unstructured":"Wu VM et al (2012) Small molecule inhibitors of smoothened ciliary localization and ciliogenesis. Proc Natl Acad Sci USA 109(34):13644\u201313649","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"12_CR286","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s10495-024-01950-9","volume":"29","author":"S Wu","year":"2024","unstructured":"Wu S et al (2024) LIPUS regulates the progression of knee osteoarthritis in mice through primary cilia-mediated TRPV4 channels. Apoptosis 29(5):785\u2013798","journal-title":"Apoptosis"},{"issue":"10","key":"12_CR287","doi-asserted-by":"publisher","first-page":"680","DOI":"10.7326\/0003-4819-155-10-201111150-00006","volume":"155","author":"A Wysocki","year":"2011","unstructured":"Wysocki A et al (2011) Whole-body vibration therapy for osteoporosis: state of the science. Ann Intern Med 155(10):680\u2013686, w206\u201313","journal-title":"Ann Intern Med"},{"issue":"1","key":"12_CR288","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41413-023-00295-4","volume":"11","author":"Z Xiao","year":"2023","unstructured":"Xiao Z et al (2023) Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice. Bone Res 11(1):57","journal-title":"Bone Res"},{"key":"12_CR289","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.bone.2016.09.008","volume":"93","author":"Y-F Xie","year":"2016","unstructured":"Xie Y-F et al (2016) Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium. Bone 93:22\u201332","journal-title":"Bone"},{"issue":"1","key":"12_CR290","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/dvdy.20197","volume":"232","author":"X Xu","year":"2005","unstructured":"Xu X et al (2005) PDGFR-\u03b1 signaling is critical for tooth cusp and palate morphogenesis. Dev Dyn 232(1):75\u201384","journal-title":"Dev Dyn"},{"issue":"6","key":"12_CR291","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1046\/j.1523-1755.2003.00023.x","volume":"63","author":"T Yamaguchi","year":"2003","unstructured":"Yamaguchi T et al (2003) Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. Kidney Int 63(6):1983\u20131994","journal-title":"Kidney Int"},{"key":"12_CR292","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ydbio.2021.12.004","volume":"482","author":"H Yamaguchi","year":"2022","unstructured":"Yamaguchi H et al (2022) Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. Dev Biol 482:91\u2013100","journal-title":"Dev Biol"},{"key":"12_CR294","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2024.100818","volume":"142","author":"H Yamaguchi","year":"2024","unstructured":"Yamaguchi H et al (2024) The primary cilia: orchestrating cranial neural crest cell development. Differentiation 100818. https:\/\/doi.org\/10.1016\/j.diff.2024.100818.\/pp32","journal-title":"Differentiation"},{"key":"12_CR334","doi-asserted-by":"publisher","unstructured":"Yamauchi M, Sricholpech M (2012) Lysine post-translational modifications of collagen. Essays Biochem 52:113\u2013533. https:\/\/doi.org\/10.1042\/bse0520113.\/pp21","DOI":"10.1042\/bse0520113.\/pp21"},{"issue":"4","key":"12_CR295","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035709","volume":"7","author":"YX Yan","year":"2012","unstructured":"Yan YX et al (2012) Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation. PLoS One 7(4):e35709","journal-title":"PLoS One"},{"key":"12_CR296","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.mce.2015.01.031","volume":"404","author":"J-L Yan","year":"2015","unstructured":"Yan J-L et al (2015) Pulsed electromagnetic fields promote osteoblast mineralization and maturation needing the existence of primary cilia. Mol Cell Endocrinol 404:132\u2013140","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"12_CR297","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3892\/ijmm.2016.2636","volume":"38","author":"Y Yan","year":"2016","unstructured":"Yan Y et al (2016) Mechanical strain promotes osteoblastic differentiation through integrin-\u03b21-mediated \u03b2-catenin signaling. Int J Mol Med 38(2):594\u2013600","journal-title":"Int J Mol Med"},{"issue":"7","key":"12_CR298","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18183","volume":"28","author":"L Yang","year":"2024","unstructured":"Yang L et al (2024) Research progress on the regulatory mechanism of integrin-mediated mechanical stress in cells involved in bone metabolism. J Cell Mol Med 28(7):e18183","journal-title":"J Cell Mol Med"},{"issue":"1","key":"12_CR299","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S8756-3282(99)00121-0","volume":"25","author":"H Yasuda","year":"1999","unstructured":"Yasuda H et al (1999) A novel molecular mechanism modulating osteoclast differentiation and function. Bone 25(1):109\u2013113","journal-title":"Bone"},{"issue":"4","key":"12_CR301","doi-asserted-by":"publisher","first-page":"159","DOI":"10.11622\/smedj.2021036","volume":"62","author":"EL Yong","year":"2021","unstructured":"Yong EL, Logan S (2021) Menopausal osteoporosis: screening, prevention and treatment. Singapore Med J 62(4):159\u2013166","journal-title":"Singapore Med J"},{"issue":"5","key":"12_CR302","doi-asserted-by":"publisher","first-page":"F1306","DOI":"10.1152\/ajprenal.00070.2020","volume":"318","author":"M Yoo","year":"2020","unstructured":"Yoo M et al (2020) Integrin-\u03b2(1) is required for the renal cystogenesis caused by ciliary defects. Am J Physiol Renal Physiol 318(5):F1306\u2013F1312","journal-title":"Am J Physiol Renal Physiol"},{"issue":"16","key":"12_CR303","doi-asserted-by":"publisher","first-page":"13365","DOI":"10.1074\/jbc.M009846200","volume":"276","author":"J You","year":"2001","unstructured":"You J et al (2001) Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 276(16):13365\u201313371","journal-title":"J Biol Chem"},{"issue":"12","key":"12_CR304","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1177\/0022034516652383","volume":"95","author":"X Yuan","year":"2016","unstructured":"Yuan X, Yang S (2016) Primary cilia and intraflagellar transport proteins in bone and cartilage. J Dent Res 95(12):1341\u20131349. https:\/\/doi.org\/10.1177\/0022034516652383.\/pp37","journal-title":"J Dent Res"},{"issue":"6","key":"12_CR305","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1073\/pnas.1112834109","volume":"109","author":"S Yuan","year":"2012","unstructured":"Yuan S et al (2012) Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proc Natl Acad Sci 109(6):2021\u20132026","journal-title":"Proc Natl Acad Sci"},{"issue":"13","key":"12_CR306","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1001\/jama.2022.1980","volume":"327","author":"L Yue","year":"2022","unstructured":"Yue L, Berman J (2022) What is osteoarthritis? JAMA 327(13):1300\u20131300","journal-title":"JAMA"},{"issue":"Pt3","key":"12_CR307","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1042\/bst0320416","volume":"32","author":"R Zaidel-Bar","year":"2004","unstructured":"Zaidel-Bar R et al (2004) Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans 32(Pt3):416\u2013420","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"12_CR308","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s40659-015-0014-y","volume":"48","author":"Q Zeng","year":"2015","unstructured":"Zeng Q et al (2015) Integrin-\u03b21, not integrin-\u03b25, mediates osteoblastic differentiation and ECM formation promoted by mechanical tensile strain. Biol Res 48(1):25","journal-title":"Biol Res"},{"issue":"12","key":"12_CR309","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006510","volume":"12","author":"H Zhang","year":"2016","unstructured":"Zhang H et al (2016) Elevated fibroblast growth factor signaling is critical for the pathogenesis of the dwarfism in Evc2\/limbin mutant mice. PLoS Genet 12(12):e1006510","journal-title":"PLoS Genet"},{"issue":"1","key":"12_CR310","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/humu.23362","volume":"39","author":"W Zhang","year":"2018","unstructured":"Zhang W et al (2018) Expanding the genetic architecture and phenotypic spectrum in the skeletal ciliopathies. Hum Mutat 39(1):152\u2013166","journal-title":"Hum Mutat"},{"issue":"12","key":"12_CR311","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1524","volume":"8","author":"X Zhang","year":"2020","unstructured":"Zhang X et al (2020) Whole-exome sequencing identified two novel mutations of DYNC2LI1 in fetal skeletal ciliopathy. Mol Genet Genomic Med 8(12):e1524","journal-title":"Mol Genet Genomic Med"},{"key":"12_CR312","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101781","volume":"76","author":"Z Zhang","year":"2022","unstructured":"Zhang Z et al (2022) Piezo1 and IFT88 synergistically regulate mandibular condylar chondrocyte differentiation under cyclic tensile strain. Tissue Cell 76:101781","journal-title":"Tissue Cell"},{"issue":"15","key":"12_CR313","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1177\/15353702231199079","volume":"248","author":"Y Zhang","year":"2023","unstructured":"Zhang Y et al (2023) Primary cilium-mediated mechanotransduction in cartilage chondrocytes. Exp Biol Med (Maywood) 248(15):1279\u20131287","journal-title":"Exp Biol Med (Maywood)"},{"issue":"11","key":"12_CR314","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1359\/jbmr.2002.17.11.2068","volume":"17","author":"S Zhao","year":"2002","unstructured":"Zhao S et al (2002) MLO-Y4 osteocyte-like cells support osteoclast formation and activation. J Bone Miner Res 17(11):2068\u20132079","journal-title":"J Bone Miner Res"},{"issue":"2","key":"12_CR315","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1083\/jcb.141.2.539","volume":"141","author":"C Zhong","year":"1998","unstructured":"Zhong C et al (1998) Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. J Cell Biol 141(2):539\u2013551","journal-title":"J Cell Biol"},{"key":"12_CR316","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52779","volume":"9","author":"T Zhou","year":"2020","unstructured":"Zhou T et al (2020) Piezo1\/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-\u00df-catenin. elife 9:e52779","journal-title":"elife"},{"key":"12_CR341","doi-asserted-by":"publisher","unstructured":"Zhou P, Zheng T, Zhao B (2022) Cytokine-mediated immunomodulation of osteoclastogenesis. Bone 164:116540. https:\/\/doi.org\/10.1016\/j.bone.2022.116540.\/p","DOI":"10.1016\/j.bone.2022.116540.\/p"}],"container-title":["Results and Problems in Cell Differentiation","Mechanotransduction and Mechanosensing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-19509-8_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:06:48Z","timestamp":1780304808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-19509-8_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032195081","9783032195098"],"references-count":351,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-19509-8_12","relation":{},"ISSN":["0080-1844","1861-0412"],"issn-type":[{"value":"0080-1844","type":"print"},{"value":"1861-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2 June 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}