{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:02:48Z","timestamp":1779667368326,"version":"3.53.1"},"publisher-location":"Cham","reference-count":20,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032200402","type":"print"},{"value":"9783032200419","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-20041-9_4","type":"book-chapter","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T23:16:51Z","timestamp":1779664611000},"page":"55-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modeling Therapeutic Targets: $$\\beta $$-Globin Disorders and Beyond"],"prefix":"10.1007","author":[{"given":"Rza","family":"Bashirov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"4_CR8","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1182\/blood-2012-11-466227","volume":"121","author":"M Amaya","year":"2013","unstructured":"Amaya M, Desai M, Pnanapragasam MN (2013) Mi2 \u03b2-mediated silencing of the fetal \u03b3-globin gene in adult erythroid cells. Blood 121:3493\u20133501","journal-title":"Blood"},{"issue":"1","key":"4_CR29","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1089\/jir.2014.0022","volume":"35","author":"MS Dahllof","year":"2015","unstructured":"Dahllof MS, Christensen DP, Harving M, Wagner BK, Mandrup-Poulsen T, Lundh M (2015) HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent. J Interf Cytok Res 35(1):63\u201370","journal-title":"J Interf Cytok Res"},{"issue":"21","key":"4_CR30","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1182\/blood.V124.21.2687.2687","volume":"124","author":"Y Dai","year":"2014","unstructured":"Dai Y, Faller DV, Sangerman JI, Fucharoen S, Perrine SP (2014) Multiple oral therapeutics suppress repressors (LSD-1, HDACs, and BCL11A) of gamma globin gene expression. Blood 124(21):2687\u20132687","journal-title":"Blood"},{"issue":"1","key":"4_CR33","first-page":"1","volume":"15","author":"S Deumic","year":"2025","unstructured":"Deumic S, Crncevic N, Hukic M, Dizdar M, Avdic M (2025) New perspectives on the impact of iron chelation therapy on the gut microbiome in thalassemia patients. Thalass Rep 15(1):1\u201310","journal-title":"Thalass Rep"},{"key":"4_CR37","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/35888","volume":"391","author":"A Fire","year":"1998","unstructured":"Fire A, Xu S, Montgomery MK et al (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806\u2013811","journal-title":"Nature"},{"issue":"11","key":"4_CR38","first-page":"1","volume":"5","author":"R Galanello","year":"2010","unstructured":"Galanello R, Origa R (2010) Beta-thalassemia. Orphanet J Rare Dis 5(11):1\u201315","journal-title":"Orphanet J Rare Dis"},{"key":"4_CR42","doi-asserted-by":"publisher","first-page":"7487","DOI":"10.1073\/pnas.1015341108","volume":"108","author":"MN Gnanapragasam","year":"2011","unstructured":"Gnanapragasam MN, Scarsdale JN, Amaya MN et al (2011) p66 \u03b1-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex. PNAS 108:7487\u20137492","journal-title":"PNAS"},{"issue":"5","key":"4_CR71","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1182\/blood-2012-07-443986","volume":"121","author":"ER Macari","year":"2013","unstructured":"Macari ER, Schaeffer EK, West RJ, Lowrey CH (2013) Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells. Blood 121(5):830\u2013839","journal-title":"Blood"},{"key":"4_CR77","doi-asserted-by":"publisher","first-page":"675","DOI":"10.2174\/156652408786241393","volume":"8","author":"JG Michlitsch","year":"2008","unstructured":"Michlitsch JG, Walters MC (2008) Recent advances in bone marrow transplantation in hemoglobinopathies. Curr Mol Med 8:675\u2013689","journal-title":"Curr Mol Med"},{"key":"4_CR83","first-page":"181","volume":"2","author":"M Nagasaki","year":"2003","unstructured":"Nagasaki M, Doi A, Matsuno H, Miyano S (2003) Genomic object net: a platform for modeling and simulating biopathways. Appl Bioinform 2:181\u2013184","journal-title":"Appl Bioinform"},{"key":"4_CR90","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1182\/asheducation-2009.1.690","volume":"2009","author":"DA Persons","year":"2009","unstructured":"Persons DA (2009) Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders. Hematology 2009:690\u2013697","journal-title":"Hematology"},{"key":"4_CR94","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.hoc.2010.08.015","volume":"24","author":"JB Porter","year":"2010","unstructured":"Porter JB, Shah FT (2010) Iron overload in thalassemia and related conditions: therapeutic goals and assessment of response to chelation therapies. Hematol Oncol Clin North Am 24:1109\u20131130","journal-title":"Hematol Oncol Clin North Am"},{"issue":"4","key":"4_CR95","doi-asserted-by":"publisher","first-page":"411","DOI":"10.2174\/1568009611313040005","volume":"13","author":"K Rao-Bindal","year":"2013","unstructured":"Rao-Bindal K, Koshkina NV, Stewart J, Kleinerman ES (2013) The histone deacetylase inhibitor, MS-275 (Entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets 13(4):411\u2013422","journal-title":"Curr Cancer Drug Targets"},{"key":"4_CR101","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1096\/fj.13-242669","volume":"28","author":"M Roosjen","year":"2014","unstructured":"Roosjen M, McColl B, Kao B et al (2014) Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal \u03b2-like globin genes. FASEB J 28:1610\u20131620","journal-title":"FASEB J"},{"key":"4_CR102","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1182\/asheducation-2011.1.459","volume":"2011","author":"VG Sankaran","year":"2011","unstructured":"Sankaran VG (2011) Targeted therapeutic strategies for fetal hemoglobin induction. Hematol Am Soc Hematol Educ Program 2011:459\u2013465","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"4_CR103","doi-asserted-by":"publisher","first-page":"a011643","DOI":"10.1101\/cshperspect.a011643","volume":"3","author":"VG Sankaran","year":"2013","unstructured":"Sankaran VG, Orkin SH (2013) The switch from fetal to adult hemoglobin. Cold Spring Harb Perspect Med 3:a011643","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"21","key":"4_CR106","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1182\/blood.V122.21.2253.2253","volume":"122","author":"JR Shearstone","year":"2013","unstructured":"Shearstone JR et al (2013) Mechanistic insights into fetal hemoglobin (HbF) induction through chemical inhibition of histone deacetylase 1 and 2 (HDAC1\/2). Blood 122(21):2253\u20132253","journal-title":"Blood"},{"key":"4_CR112","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/35066048","volume":"2","author":"DJ Weatherall","year":"2001","unstructured":"Weatherall DJ (2001) Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nat Rev 2:245\u2013255","journal-title":"Nat Rev"},{"issue":"8","key":"4_CR114","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1101\/gad.1897310","volume":"24","author":"J Xu","year":"2010","unstructured":"Xu J et al (2010) Transcriptional silencing of \u03b3-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev 24(8):783\u2013798","journal-title":"Genes Dev"},{"issue":"9","key":"4_CR117","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/ng.637","volume":"42","author":"D Zhou","year":"2010","unstructured":"Zhou D, Liu K, Sun CW, Pawlik KM, Townes TM (2010) KLF1 regulates BCL11A expression and gamma\u2013to\u2013beta\u2013globin gene switch. Nat Genet 42(9):742\u2013744","journal-title":"Nat Genet"}],"container-title":["Advances in Experimental Medicine and Biology","Petri Nets in Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-20041-9_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T23:16:52Z","timestamp":1779664612000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-20041-9_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032200402","9783032200419"],"references-count":20,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-20041-9_4","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"25 May 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}