{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:20:33Z","timestamp":1783549233235,"version":"3.55.0"},"publisher-location":"Cham","reference-count":124,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032222848","type":"print"},{"value":"9783032222855","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-22285-5_4","type":"book-chapter","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:11:19Z","timestamp":1783548679000},"page":"85-104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vascular Mechanobiology: From Membrane to Nucleus"],"prefix":"10.1007","author":[{"given":"Qing-Ping","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Peng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"10","key":"4_CR1","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1084\/jem.20180483","volume":"215","author":"J Albarr\u00e1n-Ju\u00e1rez","year":"2018","unstructured":"Albarr\u00e1n-Ju\u00e1rez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S (2018) Piezo1 and G(q)\/G(11) promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med 215(10):2655\u20132672. https:\/\/doi.org\/10.1084\/jem.20180483","journal-title":"J Exp Med"},{"issue":"6","key":"4_CR2","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1002\/tcr.202000175","volume":"21","author":"S Amemiya","year":"2021","unstructured":"Amemiya S (2021) Nanoelectrochemical study of molecular transport through the nuclear pore complex. Chem Rec 21(6):1430\u20131441. https:\/\/doi.org\/10.1002\/tcr.202000175","journal-title":"Chem Rec"},{"issue":"9","key":"4_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183316","volume":"1862","author":"A Angulo-Urarte","year":"2020","unstructured":"Angulo-Urarte A, van der Wal T, Huveneers S (2020) Cell-cell junctions as sensors and transducers of mechanical forces. Biochim Biophys Acta Biomembr 1862(9):183316. https:\/\/doi.org\/10.1016\/j.bbamem.2020.183316","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"6","key":"4_CR4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.31083\/j.fbl2806113","volume":"28","author":"L Batha","year":"2023","unstructured":"Batha L, Aziz MA, Zhra M, Holail J, Al-Qahtani WS, Fakhoury R, Aljada A (2023) Differential gene expression signatures and cellular signaling pathways induced by Lamin a\/C transcript variants in MCF7 cell line. Front Biosci (Landmark Ed) 28(6):113. https:\/\/doi.org\/10.31083\/j.fbl2806113","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"8","key":"4_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202400034","volume":"46","author":"N Belaadi","year":"2024","unstructured":"Belaadi N, Guilluy C (2024) Life outside the LINC complex \u2013 do SUN proteins have LINC-independent functions? BioEssays 46(8):e2400034. https:\/\/doi.org\/10.1002\/bies.202400034","journal-title":"BioEssays"},{"issue":"9","key":"4_CR6","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1161\/circulationaha.120.051877","volume":"143","author":"SI Bibli","year":"2021","unstructured":"Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP et al (2021) Mapping the endothelial cell S-Sulfhydrome highlights the crucial role of integrin Sulfhydration in vascular function. Circulation 143(9):935\u2013948. https:\/\/doi.org\/10.1161\/circulationaha.120.051877","journal-title":"Circulation"},{"issue":"18","key":"4_CR7","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1091\/mbc.E14-05-0971","volume":"25","author":"CR Bone","year":"2014","unstructured":"Bone CR, Tapley EC, Gorj\u00e1n\u00e1cz M, Starr DA (2014) The Caenorhabditis elegans SUN protein UNC-84 interacts with Lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration. Mol Biol Cell 25(18):2853\u20132865. https:\/\/doi.org\/10.1091\/mbc.E14-05-0971","journal-title":"Mol Biol Cell"},{"issue":"10","key":"4_CR8","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1016\/j.biocel.2010.07.001","volume":"42","author":"M Brosig","year":"2010","unstructured":"Brosig M, Ferralli J, Gelman L, Chiquet M, Chiquet-Ehrismann R (2010) Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis. Int J Biochem Cell Biol 42(10):1717\u20131728. https:\/\/doi.org\/10.1016\/j.biocel.2010.07.001","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"4_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41576-018-0063-5","volume":"20","author":"A Buchwalter","year":"2019","unstructured":"Buchwalter A, Kaneshiro JM, Hetzer MW (2019) Coaching from the sidelines: the nuclear periphery in genome regulation. Nat Rev Genet 20(1):39\u201350. https:\/\/doi.org\/10.1038\/s41576-018-0063-5","journal-title":"Nat Rev Genet"},{"issue":"1","key":"4_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bpj.2010.04.011","volume":"99","author":"TJ Chancellor","year":"2010","unstructured":"Chancellor TJ, Lee J, Thodeti CK, Lele T (2010) Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation. Biophys J 99(1):115\u2013123. https:\/\/doi.org\/10.1016\/j.bpj.2010.04.011","journal-title":"Biophys J"},{"issue":"3","key":"4_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nmat4489","volume":"15","author":"O Chaudhuri","year":"2016","unstructured":"Chaudhuri O, Gu L, Klumpers D, Darnell M, Bencherif SA, Weaver JC, Huebsch N, Lee HP, Lippens E, Duda GN, Mooney DJ (2016) Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat Mater 15(3):326\u2013334. https:\/\/doi.org\/10.1038\/nmat4489","journal-title":"Nat Mater"},{"issue":"9","key":"4_CR12","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1021\/acs.jproteome.2c00281","volume":"21","author":"LC Cheng","year":"2022","unstructured":"Cheng LC, Zhang X, Abhinav K, Nguyen JA, Baboo S, Martinez-Bartolom\u00e9 S, Branon TC, Ting AY, Loose E, Yates JR 3rd, Gerace L (2022) Shared and distinctive neighborhoods of Emerin and Lamin B receptor revealed by proximity labeling and quantitative proteomics. J Proteome Res 21(9):2197\u20132210. https:\/\/doi.org\/10.1021\/acs.jproteome.2c00281","journal-title":"J Proteome Res"},{"issue":"7","key":"4_CR13","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1161\/circresaha.124.325685","volume":"136","author":"CK Cheng","year":"2025","unstructured":"Cheng CK, Wang N, Wang L, Huang Y (2025) Biophysical and biochemical roles of shear stress on endothelium: a revisit and new insights. Circ Res 136(7):752\u2013772. https:\/\/doi.org\/10.1161\/circresaha.124.325685","journal-title":"Circ Res"},{"issue":"3","key":"4_CR14","doi-asserted-by":"publisher","first-page":"H1209","DOI":"10.1152\/ajpheart.01047.2006","volume":"292","author":"S Chien","year":"2007","unstructured":"Chien S (2007) Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol 292(3):H1209\u2013H1224. https:\/\/doi.org\/10.1152\/ajpheart.01047.2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"4_CR15","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1152\/physrev.00047.2009","volume":"91","author":"JJ Chiu","year":"2011","unstructured":"Chiu JJ, Chien S (2011) Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev 91(1):327\u2013387. https:\/\/doi.org\/10.1152\/physrev.00047.2009","journal-title":"Physiol Rev"},{"issue":"10","key":"4_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12414","volume":"13","author":"PM Coly","year":"2024","unstructured":"Coly PM, Chatterjee S, Mezine F, Jekmek CE, Devue C, Nipoti T, Mazlan S, Corona ML, Dingli F, Loew D, van Niel G, Loyer X, Boulanger CM (2024) Low fluid shear stress stimulates the uptake of noxious endothelial extracellular vesicles via MCAM and PECAM-1 cell adhesion molecules. J Extracell Vesicles 13(10):e12414. https:\/\/doi.org\/10.1002\/jev2.12414","journal-title":"J Extracell Vesicles"},{"issue":"5","key":"4_CR17","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/circresaha.123.322798","volume":"134","author":"B Coste","year":"2024","unstructured":"Coste B, Delmas P (2024) PIEZO ion channels in cardiovascular functions and diseases. Circ Res 134(5):572\u2013591. https:\/\/doi.org\/10.1161\/circresaha.123.322798","journal-title":"Circ Res"},{"key":"4_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2023.102303","volume":"86","author":"PA Coulombe","year":"2024","unstructured":"Coulombe PA, Pineda CM, Jacob JT, Nair RR (2024) Nuclear roles for non-Lamin intermediate filament proteins. Curr Opin Cell Biol 86:102303. https:\/\/doi.org\/10.1016\/j.ceb.2023.102303","journal-title":"Curr Opin Cell Biol"},{"issue":"5","key":"4_CR19","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/S0022-2836(02)00386-8","volume":"319","author":"CA Davey","year":"2002","unstructured":"Davey CA, Sargent DF, Luger K, Maeder AW, Richmond TJ (2002) Solvent mediated interactions in the structure of the nucleosome Core particle at 1.9\u00c5 resolution\u2020\u2020we dedicate this paper to the memory of max Perutz who was particularly inspirational and supportive to T.J.R. In the early stages of this study. J Mol Biol 319(5):1097\u20131113. https:\/\/doi.org\/10.1016\/S0022-2836(02)00386-8","journal-title":"J Mol Biol"},{"issue":"2","key":"4_CR20","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1152\/physrev.00053.2021","volume":"103","author":"MJ Davis","year":"2023","unstructured":"Davis MJ, Earley S, Li YS, Chien S (2023) Vascular mechanotransduction. Physiol Rev 103(2):1247\u20131421. https:\/\/doi.org\/10.1152\/physrev.00053.2021","journal-title":"Physiol Rev"},{"issue":"3","key":"4_CR21","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1042\/bst20221541","volume":"51","author":"S De Silva","year":"2023","unstructured":"De Silva S, Fan Z, Kang B, Shanahan CM, Zhang Q (2023) Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction. Biochem Soc Trans 51(3):1331\u20131345. https:\/\/doi.org\/10.1042\/bst20221541","journal-title":"Biochem Soc Trans"},{"issue":"6","key":"4_CR22","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1093\/cvr\/cvab165","volume":"118","author":"MR Diagbouga","year":"2022","unstructured":"Diagbouga MR, Morel S, Cayron AF, Haemmerli J, Georges M, Hierck BP, All\u00e9mann E, Lemeille S, Bijlenga P, Kwak BR (2022) Primary cilia control endothelial permeability by regulating expression and location of junction proteins. Cardiovasc Res 118(6):1583\u20131596. https:\/\/doi.org\/10.1093\/cvr\/cvab165","journal-title":"Cardiovasc Res"},{"key":"4_CR23","doi-asserted-by":"publisher","unstructured":"Du J, Liu P, Zhou Y, Misener S, Sharma I, Leeaw P, Thomson BR, Jin J, Quaggin SE (2024) The mechanosensory channel PIEZO1 functions upstream of angiopoietin\/TIE\/FOXO1 signaling in lymphatic development. J Clin Invest 134(10). https:\/\/doi.org\/10.1172\/jci176577","DOI":"10.1172\/jci176577"},{"issue":"9","key":"4_CR24","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1161\/circresaha.110.231860","volume":"108","author":"AD Egorova","year":"2011","unstructured":"Egorova AD, Khedoe PP, Goumans MJ, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP (2011) Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Circ Res 108(9):1093\u20131101. https:\/\/doi.org\/10.1161\/circresaha.110.231860","journal-title":"Circ Res"},{"issue":"6","key":"4_CR25","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.cell.2017.10.008","volume":"171","author":"A Elosegui-Artola","year":"2017","unstructured":"Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, Shanahan CM, Trepat X, Navajas D, Garcia-Manyes S, Roca-Cusachs P (2017) Force triggers YAP nuclear entry by regulating transport across nuclear pores. Cell 171(6):1397\u20131410.e1314. https:\/\/doi.org\/10.1016\/j.cell.2017.10.008","journal-title":"Cell"},{"issue":"7999","key":"4_CR26","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41586-023-06991-9","volume":"626","author":"W Fan","year":"2024","unstructured":"Fan W, Adebowale K, V\u00e1ncza L, Li Y, Rabbi MF, Kunimoto K, Chen D, Mozes G, Chiu DK-C, Li Y, Tao J, Wei Y, Adeniji N, Brunsing RL, Dhanasekaran R, Singhi A, Geller D, Lo SH, Hodgson L et al (2024) Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver. Nature 626(7999):635\u2013642. https:\/\/doi.org\/10.1038\/s41586-023-06991-9","journal-title":"Nature"},{"issue":"19","key":"4_CR27","doi-asserted-by":"publisher","first-page":"11500","DOI":"10.1093\/nar\/gkae752","volume":"52","author":"S Ferraioli","year":"2024","unstructured":"Ferraioli S, Sarigol F, Prakash C, Filipczak D, Foisner R, Naetar N (2024) LAP2alpha facilitates myogenic gene expression by preventing nucleoplasmic Lamin a\/C from spreading to active chromatin regions. Nucleic Acids Res 52(19):11500\u201311518. https:\/\/doi.org\/10.1093\/nar\/gkae752","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"4_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/21541248.2017.1332505","volume":"11","author":"N Fine","year":"2020","unstructured":"Fine N, Dimitriou ID, Rottapel R (2020) Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils. Small GTPases 11(1):23\u201331. https:\/\/doi.org\/10.1080\/21541248.2017.1332505","journal-title":"Small GTPases"},{"issue":"26","key":"4_CR29","doi-asserted-by":"publisher","first-page":"12980","DOI":"10.1073\/pnas.1902165116","volume":"116","author":"EE Friedrich","year":"2019","unstructured":"Friedrich EE, Hong Z, Xiong S, Zhong M, Di A, Rehman J, Komarova YA, Malik AB (2019) Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions. Proc Natl Acad Sci USA 116(26):12980\u201312985. https:\/\/doi.org\/10.1073\/pnas.1902165116","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6856-2","volume-title":"Biomechanics: motion, flow, stress, and growth","author":"YC Fung","year":"1990","unstructured":"Fung YC (1990) Biomechanics: motion, flow, stress, and growth. Springer-Verlag New York Inc"},{"key":"4_CR31","doi-asserted-by":"publisher","unstructured":"Ghimire K, Zaric J, Alday-Parejo B, Seebach J, Bousquenaud M, Stalin J, Bieler G, Schnittler HJ, R\u00fcegg C (2019) MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress. Cells 8(5). https:\/\/doi.org\/10.3390\/cells8050388","DOI":"10.3390\/cells8050388"},{"key":"4_CR32","doi-asserted-by":"publisher","unstructured":"Goumans MJ, Ten Dijke P (2018) TGF-\u03b2 signaling in control of cardiovascular function. Cold Spring Harb Perspect Biol 10(2). https:\/\/doi.org\/10.1101\/cshperspect.a022210","DOI":"10.1101\/cshperspect.a022210"},{"issue":"4","key":"4_CR33","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/ncb2927","volume":"16","author":"C Guilluy","year":"2014","unstructured":"Guilluy C, Osborne LD, Van Landeghem L, Sharek L, Superfine R, Garcia-Mata R, Burridge K (2014) Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. Nat Cell Biol 16(4):376\u2013381. https:\/\/doi.org\/10.1038\/ncb2927","journal-title":"Nat Cell Biol"},{"issue":"13","key":"4_CR34","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1093\/cvr\/cvz333","volume":"116","author":"Q Guo","year":"2020","unstructured":"Guo Q, Huang F, Qing Y, Feng S, Xiao X, Wang Y, Liang M, Wang T, Mitch WE, Cheng J (2020) Decreased Jagged1 expression in vascular smooth muscle cells delays endothelial regeneration in arteriovenous graft. Cardiovasc Res 116(13):2142\u20132155. https:\/\/doi.org\/10.1093\/cvr\/cvz333","journal-title":"Cardiovasc Res"},{"issue":"3","key":"4_CR35","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12748","volume":"17","author":"TT Hays","year":"2018","unstructured":"Hays TT, Ma B, Zhou N, Stoll S, Pearce WJ, Qiu H (2018) Vascular smooth muscle cells direct extracellular dysregulation in aor tic stiffening of hypertensive rats. Aging Cell 17(3):e12748. https:\/\/doi.org\/10.1111\/acel.12748","journal-title":"Aging Cell"},{"key":"4_CR36","doi-asserted-by":"publisher","unstructured":"Hieda M (2017) Implications for diverse functions of the LINC complexes based on the structure. Cells 6(1). https:\/\/doi.org\/10.3390\/cells6010003","DOI":"10.3390\/cells6010003"},{"issue":"3","key":"4_CR37","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.molcel.2024.11.038","volume":"85","author":"PC Hoffmann","year":"2025","unstructured":"Hoffmann PC, Kim H, Obarska-Kosinska A, Kreysing JP, Andino-Frydman E, Cruz-Le\u00f3n S, Margiotta E, Cernikova L, Kosinski J, Turo\u0148ov\u00e1 B, Hummer G, Beck M (2025) Nuclear pore permeability and fluid flow are modulated by its dilation state. Mol Cell 85(3):537\u2013554.e511. https:\/\/doi.org\/10.1016\/j.molcel.2024.11.038","journal-title":"Mol Cell"},{"key":"4_CR38","doi-asserted-by":"publisher","unstructured":"Hong SG, Ashby JW, Kennelly JP, Wu M, Steel M, Chattopadhyay E, Foreman R, Tontonoz P, Tarling EJ, Turowski P, Gallagher-Jones M, Mack JJ (2024) Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation. J Clin Invest 134(13). https:\/\/doi.org\/10.1172\/jci175057","DOI":"10.1172\/jci175057"},{"key":"4_CR39","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.gde.2021.02.003","volume":"67","author":"VE Hoskins","year":"2021","unstructured":"Hoskins VE, Smith K, Reddy KL (2021) The shifting shape of genomes: dynamics of heterochromatin interactions at the nuclear lamina. Curr Opin Genet Dev 67:163\u2013173. https:\/\/doi.org\/10.1016\/j.gde.2021.02.003","journal-title":"Curr Opin Genet Dev"},{"issue":"2","key":"4_CR40","doi-asserted-by":"publisher","DOI":"10.1063\/5.0263936","volume":"9","author":"Y Hou","year":"2025","unstructured":"Hou Y, Screen HRC, Knight MM (2025) Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP. APL Bioeng 9(2):026122. https:\/\/doi.org\/10.1063\/5.0263936","journal-title":"APL Bioeng"},{"key":"4_CR41","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-21576-1","volume-title":"Cardiovascular solid mechanics: cells, tissues, and organs","author":"JD Humphrey","year":"2002","unstructured":"Humphrey JD (2002) Cardiovascular solid mechanics: cells, tissues, and organs. Springer Science & Business Media"},{"key":"4_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-bioeng-092419-060810","volume":"23","author":"JD Humphrey","year":"2021","unstructured":"Humphrey JD, Schwartz MA (2021) Vascular Mechanobiology: homeostasis, adaptation, and disease. Annu Rev Biomed Eng 23:1\u201327. https:\/\/doi.org\/10.1146\/annurev-bioeng-092419-060810","journal-title":"Annu Rev Biomed Eng"},{"issue":"8","key":"4_CR43","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1161\/circresaha.114.304936","volume":"116","author":"JD Humphrey","year":"2015","unstructured":"Humphrey JD, Schwartz MA, Tellides G, Milewicz DM (2015) Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections. Circ Res 116(8):1448\u20131461. https:\/\/doi.org\/10.1161\/circresaha.114.304936","journal-title":"Circ Res"},{"issue":"6","key":"4_CR44","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.devcel.2020.02.011","volume":"52","author":"K Ikegami","year":"2020","unstructured":"Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP (2020) Phosphorylated Lamin A\/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria. Dev Cell 52(6):699\u2013713.e611. https:\/\/doi.org\/10.1016\/j.devcel.2020.02.011","journal-title":"Dev Cell"},{"issue":"1","key":"4_CR45","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12576-020-00745-2","volume":"70","author":"S Islam","year":"2020","unstructured":"Islam S, Yoshioka K, Aki S, Ishimaru K, Yamada H, Takuwa N, Takuwa Y (2020) Class II phosphatidylinositol 3-kinase \u03b1 and \u03b2 isoforms are required for vascular smooth muscle rho activation, contraction and blood pressure regulation in mice. J Physiol Sci 70(1):18. https:\/\/doi.org\/10.1186\/s12576-020-00745-2","journal-title":"J Physiol Sci"},{"key":"4_CR46","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ceb.2020.03.001","volume":"63","author":"CS Janota","year":"2020","unstructured":"Janota CS, Calero-Cuenca FJ, Gomes ER (2020) The role of the cell nucleus in mechanotransduction. Curr Opin Cell Biol 63:204\u2013211. https:\/\/doi.org\/10.1016\/j.ceb.2020.03.001","journal-title":"Curr Opin Cell Biol"},{"key":"4_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2025.112579","volume":"182","author":"L Jin","year":"2025","unstructured":"Jin L, Qin Y, Zhao Y, Zhou X, Zeng Y (2025) Endothelial cytoskeleton in mechanotransduction and vascular diseases. J Biomech 182:112579. https:\/\/doi.org\/10.1016\/j.jbiomech.2025.112579","journal-title":"J Biomech"},{"issue":"5","key":"4_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183206","volume":"1862","author":"YA Kadry","year":"2020","unstructured":"Kadry YA, Calderwood DA (2020) Chapter 22: structural and signaling functions of integrins. Biochim Biophys Acta Biomembr 1862(5):183206. https:\/\/doi.org\/10.1016\/j.bbamem.2020.183206","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"9","key":"4_CR49","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41580-022-00480-z","volume":"23","author":"Y Kalukula","year":"2022","unstructured":"Kalukula Y, Stephens AD, Lammerding J, Gabriele S (2022) Mechanics and functional consequences of nuclear deformations. Nat Rev Mol Cell Biol 23(9):583\u2013602. https:\/\/doi.org\/10.1038\/s41580-022-00480-z","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4_CR50","doi-asserted-by":"publisher","unstructured":"K\u00e4rki T, Tojkander S (2021) TRPV protein family-from Mechanosensing to cancer invasion. Biomolecules 11(7). https:\/\/doi.org\/10.3390\/biom11071019","DOI":"10.3390\/biom11071019"},{"key":"4_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2023.100494","volume":"28","author":"Z Kechagia","year":"2023","unstructured":"Kechagia Z, Roca-Cusachs P (2023) Cytoskeletal safeguards: protecting the nucleus from mechanical perturbations. Curr Opin Biomed Eng 28:100494. https:\/\/doi.org\/10.1016\/j.cobme.2023.100494","journal-title":"Curr Opin Biomed Eng"},{"issue":"3","key":"4_CR52","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801483","volume":"6","author":"AR Killaars","year":"2019","unstructured":"Killaars AR, Grim JC, Walker CJ, Hushka EA, Brown TE, Anseth KS (2019) Extended exposure to stiff microenvironments leads to persistent chromatin remodeling in human mesenchymal stem cells. Adv Sci 6(3):1801483. https:\/\/doi.org\/10.1002\/advs.201801483","journal-title":"Adv Sci"},{"key":"4_CR53","doi-asserted-by":"publisher","unstructured":"Kittisopikul M, Shimi T, Tatli M, Tran JR, Zheng Y, Medalia O, Jaqaman K, Adam SA, Goldman RD (2021) Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins. J Cell Biol 220(4). https:\/\/doi.org\/10.1083\/jcb.202007082","DOI":"10.1083\/jcb.202007082"},{"issue":"23","key":"4_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239058","volume":"21","author":"V Kmonickova","year":"2020","unstructured":"Kmonickova V, Frolikova M, Steger K, Komrskova K (2020) The role of the LINC complex in sperm development and function. Int J Mol Sci 21(23):9058. https:\/\/www.mdpi.com\/1422-0067\/21\/23\/9058","journal-title":"Int J Mol Sci"},{"key":"4_CR55","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/978-1-0716-1382-5_15","volume":"2299","author":"M Kofler","year":"2021","unstructured":"Kofler M, Kapus A (2021) Nucleocytoplasmic shuttling of the mechanosensitive transcription factors MRTF and YAP\/TAZ. Methods Mol Biol 2299:197\u2013216. https:\/\/doi.org\/10.1007\/978-1-0716-1382-5_15","journal-title":"Methods Mol Biol"},{"issue":"19","key":"4_CR56","doi-asserted-by":"publisher","first-page":"5798","DOI":"10.1111\/febs.16091","volume":"289","author":"H Kwon","year":"2022","unstructured":"Kwon H, Kim J, Jho EH (2022) Role of the hippo pathway and mechanisms for controlling cellular localization of YAP\/TAZ. FEBS J 289(19):5798\u20135818. https:\/\/doi.org\/10.1111\/febs.16091","journal-title":"FEBS J"},{"issue":"3","key":"4_CR57","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1172\/jci19670","volume":"113","author":"J Lammerding","year":"2004","unstructured":"Lammerding J, Schulze PC, Takahashi T, Kozlov S, Sullivan T, Kamm RD, Stewart CL, Lee RT (2004) Lamin a\/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest 113(3):370\u2013378. https:\/\/doi.org\/10.1172\/jci19670","journal-title":"J Clin Invest"},{"issue":"20","key":"4_CR58","doi-asserted-by":"publisher","first-page":"9874","DOI":"10.1093\/nar\/gkv1058","volume":"43","author":"P Li","year":"2015","unstructured":"Li P, Noegel AA (2015) Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export. Nucleic Acids Res 43(20):9874\u20139888. https:\/\/doi.org\/10.1093\/nar\/gkv1058","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"4_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107254","volume":"300","author":"C Li","year":"2024","unstructured":"Li C, Warren DT, Zhou C, De Silva S, Wilson DGS, Garcia-Maya M, Wheeler MA, Meinke P, Sawyer G, Ehler E, Wehnert M, Rao L, Zhang Q, Shanahan CM (2024) Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere. J Biol Chem 300(5):107254. https:\/\/doi.org\/10.1016\/j.jbc.2024.107254","journal-title":"J Biol Chem"},{"key":"4_CR60","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-physiol-042022-030946","volume":"86","author":"XR Lim","year":"2024","unstructured":"Lim XR, Harraz OF (2024) Mechanosensing by vascular endothelium. Annu Rev Physiol 86:71\u201397. https:\/\/doi.org\/10.1146\/annurev-physiol-042022-030946","journal-title":"Annu Rev Physiol"},{"key":"4_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.710809","volume":"12","author":"O Lityagina","year":"2021","unstructured":"Lityagina O, Dobreva G (2021) The LINC between mechanical forces and chromatin. Front Physiol 12:710809. https:\/\/doi.org\/10.3389\/fphys.2021.710809","journal-title":"Front Physiol"},{"issue":"1","key":"4_CR62","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1186\/s12967-019-02135-8","volume":"17","author":"D Liu","year":"2019","unstructured":"Liu D, Lv H, Liu Q, Sun Y, Hou S, Zhang L, Yang M, Han B, Wang G, Wang X, Du W, Nie H, Zhang R, Huang X, Hou J, Yu B (2019) Atheroprotective effects of methotrexate via the inhibition of YAP\/TAZ under disturbed flow. J Transl Med 17(1):378. https:\/\/doi.org\/10.1186\/s12967-019-02135-8","journal-title":"J Transl Med"},{"key":"4_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100735","volume":"22","author":"Z Liu","year":"2023","unstructured":"Liu Z, Mao S, Hu Y, Liu F, Shao X (2023) Hydrogel platform facilitating astrocytic differentiation through cell mechanosensing and YAP-mediated transcription. Mater Today Bio 22:100735. https:\/\/doi.org\/10.1016\/j.mtbio.2023.100735","journal-title":"Mater Today Bio"},{"key":"4_CR65","doi-asserted-by":"publisher","unstructured":"Lomakin AJ, Cattin CJ, Cuvelier D, Alraies Z, Molina M, Nader GPF, Srivastava N, S\u00e1ez PJ, Garcia-Arcos JM, Zhitnyak IY, Bhargava A, Driscoll MK, Welf ES, Fiolka R, Petrie RJ, De Silva NS, Gonz\u00e1lez-Granado JM, Manel N, Lennon-Dum\u00e9nil AM et al (2020) The nucleus acts as a ruler tailoring cell responses to spatial constraints. Science 370(6514). https:\/\/doi.org\/10.1126\/science.aba2894","DOI":"10.1126\/science.aba2894"},{"issue":"12","key":"4_CR66","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1016\/j.bbamcr.2008.09.001","volume":"1783","author":"W Lu","year":"2008","unstructured":"Lu W, Gotzmann J, Sironi L, Jaeger VM, Schneider M, L\u00fcke Y, Uhl\u00e9n M, Szigyarto CA, Brachner A, Ellenberg J, Foisner R, Noegel AA, Karakesisoglou I (2008) Sun1 forms immobile macromolecular assemblies at the nuclear envelope. Biochim Biophys Acta 1783(12):2415\u20132426. https:\/\/doi.org\/10.1016\/j.bbamcr.2008.09.001","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"4_CR67","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1091\/mbc.E10-05-0463","volume":"22","author":"YC Lussi","year":"2011","unstructured":"Lussi YC, H\u00fcgi I, Laurell E, Kutay U, Fahrenkrog B (2011) The nucleoporin Nup88 is interacting with nuclear Lamin a. Mol Biol Cell 22(7):1080\u20131090. https:\/\/doi.org\/10.1091\/mbc.E10-05-0463","journal-title":"Mol Biol Cell"},{"issue":"2","key":"4_CR68","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14036","volume":"23","author":"N Luu","year":"2024","unstructured":"Luu N, Bajpai A, Li R, Park S, Noor M, Ma X, Chen W (2024) Aging-associated decline in vascular smooth muscle cell mechanosensation is mediated by Piezo1 channel. Aging Cell 23(2):e14036. https:\/\/doi.org\/10.1111\/acel.14036","journal-title":"Aging Cell"},{"issue":"12","key":"4_CR69","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1161\/circresaha.124.324773","volume":"135","author":"N Ma","year":"2024","unstructured":"Ma N, Wu F, Liu J, Wu Z, Wang L, Li B, Liu Y, Dong X, Hu J, Fang X, Zhang H, Ai D, Zhou J, Wang X (2024) Kindlin-2 phase separation in response to flow controls vascular stability. Circ Res 135(12):1141\u20131160. https:\/\/doi.org\/10.1161\/circresaha.124.324773","journal-title":"Circ Res"},{"issue":"6276","key":"4_CR70","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1126\/science.aad8857","volume":"351","author":"J Mahamid","year":"2016","unstructured":"Mahamid J, Pfeffer S, Schaffer M, Villa E, Danev R, Cuellar LK, F\u00f6rster F, Hyman AA, Plitzko JM, Baumeister W (2016) Visualizing the molecular sociology at the HeLa cell nuclear periphery. Science 351(6276):969\u2013972. https:\/\/doi.org\/10.1126\/science.aad8857","journal-title":"Science"},{"key":"4_CR71","doi-asserted-by":"publisher","unstructured":"Maik-Rachline G, Hacohen-Lev-Ran A, Seger R (2019) Nuclear ERK: mechanism of translocation, substrates, and role in cancer. Int J Mol Sci 20(5). https:\/\/doi.org\/10.3390\/ijms20051194","DOI":"10.3390\/ijms20051194"},{"issue":"7","key":"4_CR72","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202500323","volume":"39","author":"N Marano","year":"2025","unstructured":"Marano N, Holaska JM (2025) The role of inner nuclear membrane protein emerin in myogenesis. FASEB J 39(7):e70514. https:\/\/doi.org\/10.1096\/fj.202500323","journal-title":"FASEB J"},{"issue":"1","key":"4_CR73","doi-asserted-by":"publisher","DOI":"10.1063\/5.0080480","volume":"6","author":"A Matsuda","year":"2022","unstructured":"Matsuda A, Mofrad MRK (2022) On the nuclear pore complex and its emerging role in cellular mechanotransduction. APL Bioeng 6(1):011504. https:\/\/doi.org\/10.1063\/5.0080480","journal-title":"APL Bioeng"},{"issue":"1","key":"4_CR74","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s13287-024-03884-0","volume":"15","author":"X Meng","year":"2024","unstructured":"Meng X, Zhu Y, Tan H, Daraqel B, Ming Y, Li X, Yang G, He X, Song J, Zheng L (2024) The cytoskeleton dynamics-dependent LINC complex in periodontal ligament stem cells transmits mechanical stress to the nuclear envelope and promotes YAP nuclear translocation. Stem Cell Res Ther 15(1):284. https:\/\/doi.org\/10.1186\/s13287-024-03884-0","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4_CR76","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000083094","volume":"42","author":"H Miao","year":"2005","unstructured":"Miao H, Hu YL, Shiu YT, Yuan S, Zhao Y, Kaunas R, Wang Y, Jin G, Usami S, Chien S (2005) Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations. J Vasc Res 42(1):77\u201389. https:\/\/doi.org\/10.1159\/000083094","journal-title":"J Vasc Res"},{"issue":"12","key":"4_CR77","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11883-017-0691-9","volume":"19","author":"R Mitra","year":"2017","unstructured":"Mitra R, O'Neil GL, Harding IC, Cheng MJ, Mensah SA, Ebong EE (2017) Glycocalyx in atherosclerosis-relevant endothelium function and as a therapeutic target. Curr Atheroscler Rep 19(12):63. https:\/\/doi.org\/10.1007\/s11883-017-0691-9","journal-title":"Curr Atheroscler Rep"},{"issue":"1","key":"4_CR78","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2174\/1573402111666150630140615","volume":"12","author":"AM Mohieldin","year":"2016","unstructured":"Mohieldin AM, Zubayer HS, Al Omran AJ, Saternos HC, Zarban AA, Nauli SM, AbouAlaiwi WA (2016) Vascular endothelial primary cilia: mechanosensation and hypertension. Curr Hypertens Rev 12(1):57\u201367. https:\/\/doi.org\/10.2174\/1573402111666150630140615","journal-title":"Curr Hypertens Rev"},{"issue":"3","key":"4_CR79","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/s0008-6363(01)00399-6","volume":"52","author":"EP Moiseeva","year":"2001","unstructured":"Moiseeva EP (2001) Adhesion receptors of vascular smooth muscle cells and their functions. Cardiovasc Res 52(3):372\u2013386. https:\/\/doi.org\/10.1016\/s0008-6363(01)00399-6","journal-title":"Cardiovasc Res"},{"key":"4_CR80","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.biomaterials.2015.07.063","volume":"70","author":"C Morez","year":"2015","unstructured":"Morez C, Noseda M, Paiva MA, Belian E, Schneider MD, Stevens MM (2015) Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues. Biomaterials 70:94\u2013104. https:\/\/doi.org\/10.1016\/j.biomaterials.2015.07.063","journal-title":"Biomaterials"},{"issue":"21","key":"4_CR81","doi-asserted-by":"publisher","first-page":"4958","DOI":"10.1111\/bph.15921","volume":"179","author":"GE Morris","year":"2022","unstructured":"Morris GE, Denniff MJ, Karamanavi E, Andrews SA, Kostogrys RB, Bountziouka V, Ghaderi-Najafabadi M, Shamkhi N, McConnell G, Kaiser MA, Carleton L, Schofield C, Kessler T, Rainbow RD, Samani NJ, Webb TR (2022) The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins \u03b19\u03b21 and \u03b14\u03b21. Br J Pharmacol 179(21):4958\u20134973. https:\/\/doi.org\/10.1111\/bph.15921","journal-title":"Br J Pharmacol"},{"issue":"5","key":"4_CR82","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1097\/wco.0000000000000741","volume":"32","author":"A Muchir","year":"2019","unstructured":"Muchir A, Worman HJ (2019) Emery-Dreifuss muscular dystrophy: focal point nuclear envelope. Curr Opin Neurol 32(5):728\u2013734. https:\/\/doi.org\/10.1097\/wco.0000000000000741","journal-title":"Curr Opin Neurol"},{"issue":"10","key":"4_CR83","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.tibs.2021.05.007","volume":"46","author":"LA Murray-Nerger","year":"2021","unstructured":"Murray-Nerger LA, Cristea IM (2021) Lamin post-translational modifications: emerging toggles of nuclear organization and function. Trends Biochem Sci 46(10):832\u2013847. https:\/\/doi.org\/10.1016\/j.tibs.2021.05.007","journal-title":"Trends Biochem Sci"},{"key":"4_CR84","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1234104","volume":"14","author":"W Nan","year":"2023","unstructured":"Nan W, He Y, Wang S, Zhang Y (2023) Molecular mechanism of VE-cadherin in regulating endothelial cell behaviour during angiogenesis. Front Physiol 14:1234104. https:\/\/doi.org\/10.3389\/fphys.2023.1234104","journal-title":"Front Physiol"},{"issue":"10","key":"4_CR85","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1073\/pnas.1810070116","volume":"116","author":"B Nmezi","year":"2019","unstructured":"Nmezi B, Xu J, Fu R, Armiger TJ, Rodriguez-Bey G, Powell JS, Ma H, Sullivan M, Tu Y, Chen NY, Young SG, Stolz DB, Dahl KN, Liu Y, Padiath QS (2019) Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina. Proc Natl Acad Sci USA 116(10):4307\u20134315. https:\/\/doi.org\/10.1073\/pnas.1810070116","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"4_CR86","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1161\/circulationaha.121.056640","volume":"145","author":"L Pan","year":"2022","unstructured":"Pan L, Bai P, Weng X, Liu J, Chen Y, Chen S, Ma X, Hu K, Sun A, Ge J (2022) Legumain is an endogenous modulator of integrin \u03b1v\u03b23 triggering vascular degeneration, dissection, and rupture. Circulation 145(9):659\u2013674. https:\/\/doi.org\/10.1161\/circulationaha.121.056640","journal-title":"Circulation"},{"issue":"7","key":"4_CR87","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/s41567-024-02438-8","volume":"20","author":"F Panagaki","year":"2024","unstructured":"Panagaki F, Tapia-Rojo R, Zhu T, Milmoe N, Paracuellos P, Board S, Mora M, Walker J, Rostkova E, Stannard A, Infante E, Garcia-Manyes S (2024) Structural anisotropy results in mechano-directional transport of proteins across nuclear pores. Nat Phys 20(7):1180\u20131193. https:\/\/doi.org\/10.1038\/s41567-024-02438-8","journal-title":"Nat Phys"},{"issue":"42","key":"4_CR88","doi-asserted-by":"publisher","first-page":"43462","DOI":"10.1074\/jbc.M402474200","volume":"279","author":"P Panorchan","year":"2004","unstructured":"Panorchan P, Schafer BW, Wirtz D, Tseng Y (2004) Nuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear lamina*. J Biol Chem 279(42):43462\u201343467. https:\/\/doi.org\/10.1074\/jbc.M402474200","journal-title":"J Biol Chem"},{"issue":"20","key":"4_CR89","doi-asserted-by":"publisher","first-page":"3448","DOI":"10.1038\/emboj.2010.216","volume":"29","author":"R Paw\u0142owski","year":"2010","unstructured":"Paw\u0142owski R, Rajakyl\u00e4 EK, Vartiainen MK, Treisman R (2010) An actin-regulated importin \u03b1\/\u03b2-dependent extended bipartite NLS directs nuclear import of MRTF-A. EMBO J 29(20):3448\u20133458. https:\/\/doi.org\/10.1038\/emboj.2010.216","journal-title":"EMBO J"},{"issue":"19","key":"4_CR90","doi-asserted-by":"publisher","first-page":"5293","DOI":"10.1073\/pnas.1604569113","volume":"113","author":"YX Qi","year":"2016","unstructured":"Qi YX, Yao QP, Huang K, Shi Q, Zhang P, Wang GL, Han Y, Bao H, Wang L, Li HP, Shen BR, Wang Y, Chien S, Jiang ZL (2016) Nuclear envelope proteins modulate proliferation of vascular smooth muscle cells during cyclic stretch application. Proc Natl Acad Sci USA 113(19):5293\u20135298. https:\/\/doi.org\/10.1073\/pnas.1604569113","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR91","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/978-3-319-96445-4_4","volume":"1097","author":"YX Qi","year":"2018","unstructured":"Qi YX, Han Y, Jiang ZL (2018) Mechanobiology and vascular remodeling: from membrane to nucleus. Adv Exp Med Biol 1097:69\u201382. https:\/\/doi.org\/10.1007\/978-3-319-96445-4_4","journal-title":"Adv Exp Med Biol"},{"key":"4_CR92","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.biomaterials.2014.10.023","volume":"37","author":"M Rabineau","year":"2015","unstructured":"Rabineau M, Flick F, Mathieu E, Tu A, Senger B, Voegel J-C, Lavalle P, Schaaf P, Freund J-N, Haikel Y, Vautier D (2015) Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. Biomaterials 37:144\u2013155. https:\/\/doi.org\/10.1016\/j.biomaterials.2014.10.023","journal-title":"Biomaterials"},{"key":"4_CR126","doi-asserted-by":"publisher","unstructured":"Rajgor D, Shanahan CM (2013) Nesprins: from the nuclear envelope and beyond. Expert Rev Mol Med, 5:15:e5. https:\/\/doi.org\/10.1017\/erm.2013.6","DOI":"10.1017\/erm.2013.6"},{"issue":"10","key":"4_CR93","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s11883-023-01139-6","volume":"25","author":"SG Rahaman","year":"2023","unstructured":"Rahaman SG, Mahanty M, Mukherjee P, Dutta B, Rahaman SO (2023) Mechanosensing and Mechanosignal transduction in atherosclerosis. Curr Atheroscler Rep 25(10):711\u2013721. https:\/\/doi.org\/10.1007\/s11883-023-01139-6","journal-title":"Curr Atheroscler Rep"},{"issue":"6","key":"4_CR94","doi-asserted-by":"publisher","first-page":"ar60","DOI":"10.1091\/mbc.E22-10-0476","volume":"34","author":"SMT Rahman","year":"2023","unstructured":"Rahman SMT, Haugh JM (2023) On the inference of ERK signaling dynamics from protein biosensor measurements. Mol Biol Cell 34(6):ar60. https:\/\/doi.org\/10.1091\/mbc.E22-10-0476","journal-title":"Mol Biol Cell"},{"issue":"4","key":"4_CR95","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1161\/hypertensionaha.119.13382","volume":"74","author":"JJ Reho","year":"2019","unstructured":"Reho JJ, Guo DF, Morgan DA, Rahmouni K (2019) Smooth muscle cell-specific disruption of the BBSome causes vascular dysfunction. Hypertension 74(4):817\u2013825. https:\/\/doi.org\/10.1161\/hypertensionaha.119.13382","journal-title":"Hypertension"},{"issue":"33","key":"4_CR96","doi-asserted-by":"publisher","first-page":"19854","DOI":"10.1073\/pnas.1911532117","volume":"117","author":"F Roudnicky","year":"2020","unstructured":"Roudnicky F, Zhang JD, Kim BK, Pandya NJ, Lan Y, Sach-Peltason L, Ragelle H, Strassburger P, Gruener S, Lazendic M, Uhles S, Revelant F, Eidam O, Sturm G, Kueppers V, Christensen K, Goldstein LD, Tzouros M, Banfai B et al (2020) Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells. Proc Natl Acad Sci USA 117(33):19854\u201319865. https:\/\/doi.org\/10.1073\/pnas.1911532117","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR97","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.750615","volume":"12","author":"M Sancho","year":"2021","unstructured":"Sancho M, Kyle BD (2021) The large-conductance, calcium-activated Potassium Channel: a big key regulator of cell physiology. Front Physiol 12:750615. https:\/\/doi.org\/10.3389\/fphys.2021.750615","journal-title":"Front Physiol"},{"issue":"1","key":"4_CR98","doi-asserted-by":"publisher","first-page":"6205","DOI":"10.1038\/s41467-020-20049-8","volume":"11","author":"KT Sapra","year":"2020","unstructured":"Sapra KT, Qin Z, Dubrovsky-Gaupp A, Aebi U, M\u00fcller DJ, Buehler MJ, Medalia O (2020) Nonlinear mechanics of Lamin filaments and the meshwork topology build an emergent nuclear lamina. Nat Commun 11(1):6205. https:\/\/doi.org\/10.1038\/s41467-020-20049-8","journal-title":"Nat Commun"},{"issue":"2","key":"4_CR99","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1161\/circresaha.116.309962","volume":"121","author":"KM Schubert","year":"2017","unstructured":"Schubert KM, Qiu J, Blodow S, Wiedenmann M, Lubomirov LT, Pfitzer G, Pohl U, Schneider H (2017) The AMP-related kinase (AMPK) induces ca(2+)-independent dilation of resistance arteries by interfering with actin filament formation. Circ Res 121(2):149\u2013161. https:\/\/doi.org\/10.1161\/circresaha.116.309962","journal-title":"Circ Res"},{"issue":"19","key":"4_CR100","doi-asserted-by":"publisher","first-page":"5267","DOI":"10.1016\/j.cell.2024.07.020","volume":"187","author":"D Singh","year":"2024","unstructured":"Singh D, Soni N, Hutchings J, Echeverria I, Shaikh F, Duquette M, Suslov S, Li Z, van Eeuwen T, Molloy K, Shi Y, Wang J, Guo Q, Chait BT, Fernandez-Martinez J, Rout MP, Sali A, Villa E (2024) The molecular architecture of the nuclear basket. Cell 187(19):5267\u20135281.e5213. https:\/\/doi.org\/10.1016\/j.cell.2024.07.020","journal-title":"Cell"},{"issue":"12","key":"4_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e12147","volume":"8","author":"MA Smith","year":"2022","unstructured":"Smith MA, Blankman E, Jensen CC, Hoffman LM, Ullman KS, Beckerle MC (2022) Nuclear pore complexes concentrate on actin\/LINC\/Lamin nuclear lines in response to mechanical stress in a SUN1 dependent manner. Heliyon 8(12):e12147. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e12147","journal-title":"Heliyon"},{"issue":"14","key":"4_CR102","doi-asserted-by":"publisher","first-page":"ar137","DOI":"10.1091\/mbc.E22-01-0007","volume":"33","author":"L Snyers","year":"2022","unstructured":"Snyers L, L\u00f6hnert R, Weipoltshammer K, Sch\u00f6fer C (2022) Emerin prevents BAF-mediated aggregation of Lamin a on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation. Mol Biol Cell 33(14):ar137. https:\/\/doi.org\/10.1091\/mbc.E22-01-0007","journal-title":"Mol Biol Cell"},{"key":"4_CR103","doi-asserted-by":"publisher","DOI":"10.1038\/srep23412","volume":"6","author":"KH Song","year":"2016","unstructured":"Song KH, Lee J, Park H, Kim HM, Park J, Kwon KW, Doh J (2016) Roles of endothelial A-type lamins in migration of T cells on and under endothelial layers. Sci Rep 6:23412. https:\/\/doi.org\/10.1038\/srep23412","journal-title":"Sci Rep"},{"issue":"5","key":"4_CR104","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.cell.2012.03.046","volume":"149","author":"BA Sosa","year":"2012","unstructured":"Sosa BA, Rothballer A, Kutay U, Schwartz TU (2012) LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins. Cell 149(5):1035\u20131047. https:\/\/doi.org\/10.1016\/j.cell.2012.03.046","journal-title":"Cell"},{"key":"4_CR105","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fgene.2017.00060","volume":"8","author":"M Spichal","year":"2017","unstructured":"Spichal M, Fabre E (2017) The emerging role of the cytoskeleton in chromosome dynamics. Front Genet 8:60. https:\/\/doi.org\/10.3389\/fgene.2017.00060","journal-title":"Front Genet"},{"issue":"4","key":"4_CR106","doi-asserted-by":"publisher","DOI":"10.1111\/apha.70030","volume":"241","author":"C Staehr","year":"2025","unstructured":"Staehr C, Hinkley V, Matchkov VV, Rajanathan R, Hansen LMB, Eiby Y, Luque N, Wright I, Bjorkman ST, Miller SM, Grimley RS, Dettrick A, Chand K, Nguyen HL, Jones NM, Murphy TV, Sandow SL (2025) Hypoxia and ischemic stroke modify cerebrovascular tone by upregulating endothelial BK(ca) channels-lessons from rat, pig, mouse, and human. Acta Physiol (Oxf) 241(4):e70030. https:\/\/doi.org\/10.1111\/apha.70030","journal-title":"Acta Physiol (Oxf)"},{"issue":"6149","key":"4_CR107","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240104","volume":"341","author":"J Swift","year":"2013","unstructured":"Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, Pajerowski JD, Spinler KR, Shin JW, Tewari M, Rehfeldt F, Speicher DW, Discher DE (2013) Nuclear Lamin-a scales with tissue stiffness and enhances matrix-directed differentiation. Science 341(6149):1240104. https:\/\/doi.org\/10.1126\/science.1240104","journal-title":"Science"},{"issue":"3","key":"4_CR108","doi-asserted-by":"publisher","first-page":"H566","DOI":"10.1152\/ajpheart.00379.2018","volume":"316","author":"LY Tanaka","year":"2019","unstructured":"Tanaka LY, Araujo TLS, Rodriguez AI, Ferraz MS, Pelegati VB, Morais MCC, Santos AMD, Cesar CL, Ramos AF, Alencar AM, Laurindo FRM (2019) Peri\/epicellular protein disulfide isomerase-A1 acts as an upstream or ganizer of cytoskeletal mechanoadaptation in vascular smooth muscle ce lls. Am J Physiol Heart Circ Physiol 316(3):H566\u2013H579. https:\/\/doi.org\/10.1152\/ajpheart.00379.2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"15","key":"4_CR109","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1038\/s44318-024-00142-0","volume":"43","author":"K Tanaka","year":"2024","unstructured":"Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA (2024) Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. EMBO J 43(15):3175\u20133191. https:\/\/doi.org\/10.1038\/s44318-024-00142-0","journal-title":"EMBO J"},{"issue":"2","key":"4_CR110","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1177\/1074248407313737","volume":"13","author":"DD Tang","year":"2008","unstructured":"Tang DD, Anfinogenova Y (2008) Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J Cardiovasc Pharmacol Ther 13(2):130\u2013140. https:\/\/doi.org\/10.1177\/1074248407313737","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"1","key":"4_CR111","doi-asserted-by":"publisher","DOI":"10.1063\/5.0082656","volume":"6","author":"A Vahabikashi","year":"2022","unstructured":"Vahabikashi A, Adam SA, Medalia O, Goldman RD (2022) Nuclear lamins: structure and function in mechanobiology. APL Bioeng 6(1):011503. https:\/\/doi.org\/10.1063\/5.0082656","journal-title":"APL Bioeng"},{"issue":"12","key":"4_CR112","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1038\/s41551-021-00709-w","volume":"5","author":"CJ Walker","year":"2021","unstructured":"Walker CJ, Crocini C, Ramirez D, Killaars AR, Grim JC, Aguado BA, Clark K, Allen MA, Dowell RD, Leinwand LA, Anseth KS (2021) Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts. Nat Biomed Eng 5(12):1485\u20131499. https:\/\/doi.org\/10.1038\/s41551-021-00709-w","journal-title":"Nat Biomed Eng"},{"key":"4_CR113","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.biocel.2014.11.011","volume":"59","author":"XJ Wan","year":"2015","unstructured":"Wan XJ, Zhao HC, Zhang P, Huo B, Shen BR, Yan ZQ, Qi YX, Jiang ZL (2015) Involvement of BK channel in differentiation of vascular smooth muscle cells induced by mechanical stretch. Int J Biochem Cell Biol 59:21\u201329. https:\/\/doi.org\/10.1016\/j.biocel.2014.11.011","journal-title":"Int J Biochem Cell Biol"},{"key":"4_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105412","volume":"110","author":"Y Wang","year":"2024","unstructured":"Wang Y, Chatterjee E, Li G, Xu J, Xiao J (2024) Force-sensing protein expression in response to cardiovascular mechanotransduction. EBioMedicine 110:105412. https:\/\/doi.org\/10.1016\/j.ebiom.2024.105412","journal-title":"EBioMedicine"},{"key":"4_CR115","doi-asserted-by":"publisher","unstructured":"Wang J, Yuan Z, Yu N, Jiao Q, Zhou H, Liao W, Shan J, Ruan S, Zhao Y, Mo Y, Qi L, Li T, Fu J, Ke B, Xu Y, Qian X, Zhang J, Zhao Z, Li S et al (2025) Inactivation of RhoA for hypertension treatment through the TRPV4-RhoA-RhoGDI1 Axis. Circulation. https:\/\/doi.org\/10.1161\/circulationaha.124.071884","DOI":"10.1161\/circulationaha.124.071884"},{"key":"4_CR116","volume-title":"Cellular Mechanotransduction: diverse perspectives from molecules to tissues","author":"C Wolf","year":"2009","unstructured":"Wolf C, Mofrad MRK (2009) In: Kamm RD, Mofrad MRK (eds) Cellular Mechanotransduction: diverse perspectives from molecules to tissues. Cambridge University Press"},{"issue":"11","key":"4_CR117","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/s41580-024-00773-5","volume":"25","author":"B Xiao","year":"2024","unstructured":"Xiao B (2024) Mechanisms of mechanotransduction and physiological roles of PIEZO channels. Nat Rev Mol Cell Biol 25(11):886\u2013903. https:\/\/doi.org\/10.1038\/s41580-024-00773-5","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"4_CR118","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12964-022-00976-3","volume":"20","author":"Y Xue","year":"2022","unstructured":"Xue Y, Wang X, Wan B, Wang D, Li M, Cheng K, Luo Q, Wang D, Lu Y, Zhu L (2022) Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema. Cell Commun Signal 20(1):160. https:\/\/doi.org\/10.1186\/s12964-022-00976-3","journal-title":"Cell Commun Signal"},{"issue":"6","key":"4_CR119","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/nmat3889","volume":"13","author":"C Yang","year":"2014","unstructured":"Yang C, Tibbitt MW, Basta L, Anseth KS (2014) Mechanical memory and dosing influence stem cell fate. Nat Mater 13(6):645\u2013652. https:\/\/doi.org\/10.1038\/nmat3889","journal-title":"Nat Mater"},{"issue":"9","key":"4_CR120","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1002\/ar.22983","volume":"297","author":"GJ Ye","year":"2014","unstructured":"Ye GJ, Nesmith AP, Parker KK (2014) The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function. Anat Rec (Hoboken) 297(9):1758\u20131769. https:\/\/doi.org\/10.1002\/ar.22983","journal-title":"Anat Rec (Hoboken)"},{"issue":"1","key":"4_CR121","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41420-023-01467-1","volume":"9","author":"X Yue","year":"2023","unstructured":"Yue X, Cui J, Sun Z, Liu L, Li Y, Shao L, Feng Q, Wang Z, Hambright WS, Cui Y, Huard J, Mu Y, Mu X (2023) Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence. Cell Death Discov 9(1):167. https:\/\/doi.org\/10.1038\/s41420-023-01467-1","journal-title":"Cell Death Discov"},{"issue":"1","key":"4_CR122","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1161\/hypertensionaha.117.09767","volume":"71","author":"P Zhang","year":"2018","unstructured":"Zhang P, Sun C, Li H, Tang C, Kan H, Yang Z, Mao A, Ma X (2018) TRPV4 (transient receptor potential Vanilloid 4) mediates endothelium-dependent contractions in the aortas of hypertensive mice. Hypertension 71(1):134\u2013142. https:\/\/doi.org\/10.1161\/hypertensionaha.117.09767","journal-title":"Hypertension"},{"issue":"1","key":"4_CR123","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41392-023-01464-x","volume":"8","author":"M Zhang","year":"2023","unstructured":"Zhang M, Ma Y, Ye X, Zhang N, Pan L, Wang B (2023) TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Signal Transduct Target Ther 8(1):261. https:\/\/doi.org\/10.1038\/s41392-023-01464-x","journal-title":"Signal Transduct Target Ther"},{"key":"4_CR124","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109900","volume":"80","author":"L Zhu","year":"2021","unstructured":"Zhu L, Yang H, Chao Y, Gu Y, Zhang J, Wang F, Yu W, Ye P, Chu P, Kong X, Chen S (2021) Akt phosphorylation regulated by IKK\u03b5 in response to low shear stress leads to endothelial inflammation via activating IRF3. Cell Signal 80:109900. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109900","journal-title":"Cell Signal"},{"issue":"6573","key":"4_CR125","doi-asserted-by":"publisher","first-page":"eabd9776","DOI":"10.1126\/science.abd9776","volume":"374","author":"CE Zimmerli","year":"2021","unstructured":"Zimmerli CE, Allegretti M, Rantos V, Goetz SK, Obarska-Kosinska A, Zagoriy I, Halavatyi A, Hummer G, Mahamid J, Kosinski J, Beck M (2021) Nuclear pores dilate and constrict in cellulo. Science 374(6573):eabd9776. https:\/\/doi.org\/10.1126\/science.abd9776","journal-title":"Science"}],"container-title":["Advances in Experimental Medicine and Biology","Molecular, Cellular, and Tissue Engineering of the Vascular System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-22285-5_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:11:21Z","timestamp":1783548681000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-22285-5_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032222848","9783032222855"],"references-count":124,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-22285-5_4","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2 June 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}