{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:07:28Z","timestamp":1778717248519,"version":"3.51.4"},"publisher-location":"Cham","reference-count":84,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032223395","type":"print"},{"value":"9783032223401","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-22340-1_7","type":"book-chapter","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:09:38Z","timestamp":1778713778000},"page":"159-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic Analysis of COVID-19 Infection"],"prefix":"10.1007","author":[{"given":"Timothy Daniel","family":"Veenstra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"7_CR1","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.1038\/s41467-023-41159-z","volume":"14","author":"H Baba\u010di\u0107","year":"2023","unstructured":"Baba\u010di\u0107 H, Christ W, Ara\u00fajo JE, Mermelekas G, Sharma N, Tynell J et al (2023) Comprehensive proteomics and meta-analysis of COVID-19 host response. Nat Commun 14:5921\u20135928","journal-title":"Nat Commun"},{"key":"7_CR2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1556\/1886.2021.00020","volume":"11","author":"P Behzadi","year":"2021","unstructured":"Behzadi P, Gajd\u00e1cs M (2021) Worldwide Protein Data Bank (wwPDB): a virtual treasure for research in biotechnology. Eur J Microbiol Immunol 11:77\u201386","journal-title":"Eur J Microbiol Immunol"},{"key":"7_CR3","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3390\/microorganisms11051209","volume":"11","author":"S Beltrami","year":"2023","unstructured":"Beltrami S, Rizzo S, Caccuri F, Rizzo R, Bortolotti D, Schiuma G (2023) SARS-CoV-2 systemic effects: new clues. Microorganisms 11:1209\u20131215","journal-title":"Microorganisms"},{"key":"7_CR4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/1752-0509-5-169","volume":"5","author":"GC Brito","year":"2011","unstructured":"Brito GC, Andrews DW (2011) Removing bias against membrane proteins in interaction networks. BMC Syst Biol 5:169\u2013193","journal-title":"BMC Syst Biol"},{"key":"7_CR5","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.3390\/ijms21083004","volume":"21","author":"SA Bustin","year":"2020","unstructured":"Bustin SA, Nolan T (2020) RT-qPCR testing of SARS-CoV-2: a primer. Int J Mol Sci 21:3004\u20133012","journal-title":"Int J Mol Sci"},{"key":"7_CR6","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s42770-022-00743-z","volume":"53","author":"KL Candido","year":"2022","unstructured":"Candido KL, Eich CR, de Fari\u00f1a LO, Kadowaki MK, da Concei\u00e7\u00e3o Silva JL, Maller A et al (2022) Spike protein of SARS-CoV-2 variants: a brief review and practical implications. Braz J Microbiol 53:1133\u20131157","journal-title":"Braz J Microbiol"},{"key":"7_CR7","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1038\/s41467-021-22785-x","volume":"12","author":"C Cao","year":"2021","unstructured":"Cao C, Cai Z, Xiao X, Rao J, Chen J, Hu N et al (2021) The architecture of the SARS-CoV-2 RNA genome inside virion. Nat Commun 12:3917\u20133930","journal-title":"Nat Commun"},{"key":"7_CR8","doi-asserted-by":"publisher","first-page":"6201","DOI":"10.1038\/s41467-020-19925-0","volume":"11","author":"KHM Cardozo","year":"2020","unstructured":"Cardozo KHM, Lebkuchen A, Okai GG, Schuch RA, Viana LG, Olive AN et al (2020) Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts. Nat Commun 11:6201\u20136213","journal-title":"Nat Commun"},{"key":"7_CR9","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1161\/01.ATV.0000145016.69181.fa","volume":"24","author":"JW Chen","year":"2004","unstructured":"Chen JW, Lin FY, Chen YH, Wu TC, Chen YL, Lin SJ (2004) Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. Arterioscler Thromb Vasc Biol 24:2075\u20132081","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"7_CR10","doi-asserted-by":"publisher","first-page":"106634","DOI":"10.1016\/j.isci.2023.106634","volume":"26","author":"DY Chen","year":"2023","unstructured":"Chen DY, Turcinovic J, Feng S, Kenney DJ, Chin CV, Choudhary MC et al (2023) Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus. iScience 26:106634\u2013106655","journal-title":"iScience"},{"key":"7_CR11","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.jacc.2021.07.003","volume":"78","author":"A Clemente-Morag\u00f3n","year":"2021","unstructured":"Clemente-Morag\u00f3n A, Mart\u00ednez-Milla J, Oliver E, Santos A, Flandes J, Fern\u00e1ndez I et al (2021) Metoprolol in critically ill patients with COVID-19. J Am Coll Cardiol 78:1001\u20131011","journal-title":"J Am Coll Cardiol"},{"key":"7_CR12","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","volume":"5","author":"Coronaviridae Study Group of the International Committee on Taxonomy of Viruses","year":"2020","unstructured":"Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (2020) The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 5:536\u2013544","journal-title":"Nat Microbiol"},{"key":"7_CR13","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.chembiol.2023.06.028","volume":"30","author":"S Datta","year":"2023","unstructured":"Datta S, Chen DY, Tavares AH, Reyes-Robles T, Ryu KA, Khan N et al (2023) High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface. Cell Chem Biol 30:1313\u20131322.e7","journal-title":"Cell Chem Biol"},{"key":"7_CR14","doi-asserted-by":"publisher","first-page":"7441","DOI":"10.1128\/JVI.73.9.7441-7452.1999","volume":"73","author":"CA de Haan","year":"1999","unstructured":"de Haan CA, Smeets M, Vernooij F, Vennema H, Rottier PJ (1999) Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein. J Virol 73:7441\u20137452","journal-title":"J Virol"},{"key":"7_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nri3344","volume":"13","author":"MS Diamond","year":"2013","unstructured":"Diamond MS, Farzan M (2013) The broad-spectrum antiviral functions of IFIT and IFITM proteins. Nat Rev Immunol 13:46\u201357","journal-title":"Nat Rev Immunol"},{"key":"7_CR16","doi-asserted-by":"publisher","first-page":"100805","DOI":"10.1016\/j.mcpro.2024.100805","volume":"2","author":"N Drouin","year":"2024","unstructured":"Drouin N, Elfrink HL, Boers SA, van Hugten S, Wessels E, de Vries JJC et al (2024) A targeted LC-MRM3 proteomic approach for the diagnosis of SARS-CoV-2 infection in nasopharyngeal swabs. Mol Cell Proteomics 2:100805\u2013100820","journal-title":"Mol Cell Proteomics"},{"key":"7_CR17","doi-asserted-by":"publisher","first-page":"mjad030","DOI":"10.1093\/jmcb\/mjad030","volume":"15","author":"L Du","year":"2023","unstructured":"Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST et al (2023) Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells. J Mol Cell Biol 15:mjad030","journal-title":"J Mol Cell Biol"},{"key":"7_CR18","doi-asserted-by":"publisher","first-page":"e1006546","DOI":"10.1371\/journal.ppat.1006546","volume":"13","author":"JT Earnest","year":"2017","unstructured":"Earnest JT, Hantak MP, Li K, McCray PB Jr, Perlman S, Gallagher T (2017) The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. PLoS Pathog 13:e1006546\u2013e1006567","journal-title":"PLoS Pathog"},{"key":"7_CR19","doi-asserted-by":"publisher","first-page":"100847","DOI":"10.1016\/j.jbc.2021.100847","volume":"297","author":"JP Evans","year":"2021","unstructured":"Evans JP, Liu SL (2021) Role of host factors in SARS-CoV-2 entry. J Biol Chem 297:100847\u2013100856","journal-title":"J Biol Chem"},{"key":"7_CR20","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMra2026131","volume":"383","author":"DC Fajgenbaum","year":"2020","unstructured":"Fajgenbaum DC, June CH (2020) Cytokine storm. N Engl J Med 383:2255\u20132273","journal-title":"N Engl J Med"},{"key":"7_CR21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3390\/v6020535","volume":"6","author":"L F\u00e9n\u00e9ant","year":"2014","unstructured":"F\u00e9n\u00e9ant L, Levy S, Cocquerel L (2014) CD81 and hepatitis C virus (HCV) infection. Viruses 6:535\u2013572","journal-title":"Viruses"},{"key":"7_CR22","doi-asserted-by":"publisher","first-page":"100287","DOI":"10.1016\/j.xcrm.2021.100287","volume":"2","author":"MR Filbin","year":"2021","unstructured":"Filbin MR, Mehta A, Schneider AM, Kays KR, Guess JR, Gentili M et al (2021) Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions. Cell Rep Med 2:100287\u2013100310","journal-title":"Cell Rep Med"},{"key":"7_CR23","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1164\/rccm.202012-4461OC","volume":"204","author":"L Gerard","year":"2021","unstructured":"Gerard L, Lecocq M, Bouzin C, Hoton D, Schmit G, Pereira JP et al (2021) Increased angiotensin-converting enzyme 2 and loss of alveolar type ii cells in COVID-19-related acute respiratory distress syndrome. Am J Respir Crit Care Med 204:1024\u20131034","journal-title":"Am J Respir Crit Care Med"},{"key":"7_CR24","first-page":"543","volume":"29","author":"L Gold","year":"2012","unstructured":"Gold L, Walker JJ, Wilcox SK, Williams S (2012) Advances in human proteomics at high scale with the SOMAscan proteomics platform. Nat Biotechnol 29:543\u2013549","journal-title":"Nat Biotechnol"},{"key":"7_CR25","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41586-020-2286-9","volume":"583","author":"DE Gordon","year":"2020","unstructured":"Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM et al (2020) A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583:459\u2013468","journal-title":"Nature"},{"key":"7_CR26","doi-asserted-by":"publisher","first-page":"D282","DOI":"10.1093\/nar\/gkaa731","volume":"49","author":"R Gowthaman","year":"2021","unstructured":"Gowthaman R, Guest JD, Yin R, Adolf-Bryfogle J, Schief WR, Pierce BG (2021) CoV3D: a database of high resolution coronavirus protein structures. Nucleic Acids Res 49:D282\u2013D287","journal-title":"Nucleic Acids Res"},{"key":"7_CR27","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12964-023-01310-1","volume":"21","author":"J Guo","year":"2023","unstructured":"Guo J, Guo S, Lu S, Gong J, Wang L, Ding L et al (2023) The development of proximity labeling technology and its applications in mammals, plants, and microorganisms. Cell Commun Signal 21:269\u2013290","journal-title":"Cell Commun Signal"},{"key":"7_CR28","doi-asserted-by":"publisher","first-page":"e9610","DOI":"10.15252\/msb.20209610","volume":"16","author":"F Hikmet","year":"2020","unstructured":"Hikmet F, M\u00e9ar L, Edvinsson \u00c5, Micke P, Uhl\u00e9n M, Lindskog C (2020) The protein expression profile of ACE2 in human tissues. Mol Syst Biol 16:e9610\u2013e9615","journal-title":"Mol Syst Biol"},{"key":"7_CR29","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","volume":"181","author":"M Hoffmann","year":"2020","unstructured":"Hoffmann M, Kleine-Weber H, Schroeder S, Kr\u00fcger N, Herrler T, Erichsen S et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181:271\u2013280.e8","journal-title":"Cell"},{"key":"7_CR30","doi-asserted-by":"publisher","first-page":"H1313","DOI":"10.1152\/ajpheart.00816.2005","volume":"290","author":"M Hoshijima","year":"2006","unstructured":"Hoshijima M (2006) Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures. Am J Physiol Heart Circ Physiol 290:H1313\u2013H1325","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"7_CR31","unstructured":"https:\/\/en.wikipedia.org\/wiki\/The_Greatest_Canadian. Accessed May 2025"},{"key":"7_CR32","unstructured":"https:\/\/theweek.com\/speedreads\/905623\/dr-birx-faces-200000-coronavirus-deaths-even-everything-almost-perfectly. Accessed May 2025"},{"key":"7_CR33","unstructured":"https:\/\/www.cdc.gov\/museum\/timeline\/covid19.html. Accessed May 2025"},{"key":"7_CR34","unstructured":"https:\/\/www.tfri.ca\/about\/terry-fox. Accessed May 2025"},{"key":"7_CR35","unstructured":"https:\/\/www.twinkl.com\/search?q=terry+fox&c=226&r=teacher&fl=12&fco=4213. Accessed May 2025"},{"key":"7_CR36","unstructured":"https:\/\/www.worldometers.info\/coronavirus\/coronavirus-death-toll\/. Accessed May 2025"},{"key":"7_CR37","doi-asserted-by":"publisher","first-page":"1415885","DOI":"10.3389\/fcimb.2024.1415885","volume":"14","author":"Y Huang","year":"2024","unstructured":"Huang Y, Chen J, Chen S, Huang C, Li B, Li J et al (2024) Molecular characterization of SARS-CoV-2 nucleocapsid protein. Front Cell Infect Microbiol 14:1415885\u20131415896","journal-title":"Front Cell Infect Microbiol"},{"key":"7_CR38","doi-asserted-by":"publisher","first-page":"6677","DOI":"10.1128\/JVI.06860-11","volume":"86","author":"R Ismailia","year":"2012","unstructured":"Ismailia R, Hsao JC, Chung CS, Chen CH, Hsu PW, Liao CL et al (2012) Integrin \u03b21 mediates vaccinia virus entry through activation of PI3K\/Akt signaling. J Virol 86:6677\u20136687","journal-title":"J Virol"},{"key":"7_CR39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","volume":"23","author":"CB Jackson","year":"2022","unstructured":"Jackson CB, Farzan M, Chen B, Choe H (2022) Mechanisms of SARS-CoV-2 entry into cells. Nat Rev Mol Cell Biol 23:3\u201320","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7_CR40","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1038\/s12276-022-00872-3","volume":"54","author":"JA Kang","year":"2022","unstructured":"Kang JA, Kim YJ, Jeon YJ (2022) The diverse repertoire of ISG15: more intricate than initially thought. Exp Mol Med 54:1779\u20131792","journal-title":"Exp Mol Med"},{"key":"7_CR41","doi-asserted-by":"publisher","first-page":"e17459","DOI":"10.15252\/emmm.202317459","volume":"15","author":"M Karlsson","year":"2023","unstructured":"Karlsson M, Zhang C, M\u00e9ar L, Zhong W, Digre A, Katona B et al (2023) Quantitative multiorgan proteomics of fatal COVID-19 uncovers tissue-specific effects beyond inflammation. EMBO Mol Med 15:e17459\u2013e17479","journal-title":"EMBO Mol Med"},{"key":"7_CR42","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/nri888","volume":"2","author":"MG Katze","year":"2002","unstructured":"Katze MG, He Y, Gale M Jr (2002) Viruses and interferon: a fight for supremacy. Nat Rev Immunol 2:675\u2013687","journal-title":"Nat Rev Immunol"},{"key":"7_CR43","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jmii.2020.05.016","volume":"54","author":"CC Lai","year":"2021","unstructured":"Lai CC, Wang CY, Ko WC, Hsueh PR (2021) In vitro diagnostics of coronavirus disease 2019: technologies and application. J Microbiol Immunol Infect 54:164\u2013174","journal-title":"J Microbiol Immunol Infect"},{"key":"7_CR44","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41579-022-00713-0","volume":"20","author":"MM Lamers","year":"2022","unstructured":"Lamers MM, Haagmans BL (2022) SARS-CoV-2 pathogenesis. Nat Rev Microbiol 20:270\u2013284","journal-title":"Nat Rev Microbiol"},{"key":"7_CR45","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/S2213-2600(20)30404-5","volume":"8","author":"DE Leisman","year":"2020","unstructured":"Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS et al (2020) Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med 8:1233\u20131244","journal-title":"Lancet Respir Med"},{"key":"7_CR46","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.medj.2020.07.002","volume":"2","author":"J Li","year":"2021","unstructured":"Li J, Guo M, Tian X, Wang X, Yang X, Wu P et al (2021) Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis. Med 2:99\u2013112.e7","journal-title":"Med"},{"key":"7_CR47","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.antiviral.2014.06.013","volume":"109","author":"DX Liu","year":"2014","unstructured":"Liu DX, Fung TS, Chong KK, Shukla A, Hilgenfeld R (2014) Accessory proteins of SARS-CoV and other coronaviruses. Antivir Res 109:97\u2013109","journal-title":"Antivir Res"},{"key":"7_CR48","doi-asserted-by":"publisher","first-page":"41135","DOI":"10.1074\/jbc.M111.302596","volume":"286","author":"H Luo","year":"2011","unstructured":"Luo H, Charpentier T, Wang X, Qi S, Han B, Wu T et al (2011) Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling. J Biol Chem 286:41135\u201341152","journal-title":"J Biol Chem"},{"key":"7_CR49","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01746-18","volume":"93","author":"EA Machala","year":"2019","unstructured":"Machala EA, Avdic S, Stern L, Zajonc DM, Benedict CA, Blyth E et al (2019) Restriction of human cytomegalovirus infection by galectin-9. J Virol 93:e01746-18","journal-title":"J Virol"},{"key":"7_CR50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41580-021-00432-z","volume":"23","author":"B Malone","year":"2022","unstructured":"Malone B, Urakova N, Snijder EJ, Campbell EA (2022) Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design. Nat Rev Mol Cell Biol 23:21\u201339","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7_CR51","doi-asserted-by":"publisher","first-page":"14381","DOI":"10.1021\/acsomega.4c00042","volume":"9","author":"J Marquez","year":"2024","unstructured":"Marquez J, Weldemariam MM, Dong J, Hayashi J, Kane MA, Serrero G (2024) Effect of PTFGRN expression on the proteomic profile of A431 cells and determination of the PTGFRN interactome. ACS Omega 9:14381\u201314387","journal-title":"ACS Omega"},{"key":"7_CR52","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1083\/jcb.153.5.1111","volume":"153","author":"JA Martina","year":"2001","unstructured":"Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (2001) Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. J Cell Biol 153:1111\u20131120","journal-title":"J Cell Biol"},{"key":"7_CR53","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1021\/jasms.3c00035","volume":"34","author":"CB Maxwell","year":"2023","unstructured":"Maxwell CB, Sandhu JK, Cao TH, McCann GP, Ng LL, Jones DJL (2023) The edge effect in high-throughput proteomics: a cautionary tale. J Am Soc Mass Spectrom 34:1065\u20131072","journal-title":"J Am Soc Mass Spectrom"},{"key":"7_CR54","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3390\/v14030611","volume":"14","author":"DG May","year":"2022","unstructured":"May DG, Martin-Sancho L, Anschau V, Liu S, Chrisopulos RJ, Scott KL et al (2022) A BioID-derived proximity interactome for SARS-CoV-2 proteins. Viruses 14:611\u2013632","journal-title":"Viruses"},{"key":"7_CR55","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1016\/j.jprot.2011.04.011","volume":"74","author":"Z Meng","year":"2011","unstructured":"Meng Z, Veenstra TD (2011) Targeted mass spectrometry approaches for protein biomarker verification. J Proteome 74:2650\u20132659","journal-title":"J Proteome"},{"key":"7_CR56","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1080\/22221751.2020.1870414","volume":"10","author":"M Moustaqil","year":"2021","unstructured":"Moustaqil M, Ollivier E, Chiu HP, Van Tol S, Rudolffi-Soto P, Stevens C et al (2021) SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species. Emerg Microbes Infect 10:178\u2013195","journal-title":"Emerg Microbes Infect"},{"key":"7_CR57","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2021.01.004","volume":"184","author":"X Nie","year":"2021","unstructured":"Nie X, Qian L, Sun R, Huang B, Dong X, Xiao Q et al (2021) Multi-organ proteomic landscape of COVID-19 autopsies. Cell 184:775\u2013791","journal-title":"Cell"},{"key":"7_CR58","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.autrev.2010.12.009","volume":"10","author":"KG Oikonomou","year":"2011","unstructured":"Oikonomou KG, Zachou K, Dalekos GN (2011) Alpha-actinin: a multidisciplinary protein with important role in B-cell driven autoimmunity. Autoimmun Rev 10:389\u2013396","journal-title":"Autoimmun Rev"},{"key":"7_CR59","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.3390\/cells10061419","volume":"10","author":"LJ Partridge","year":"2021","unstructured":"Partridge LJ, Urwin L, Nicklin MJH, James DC, Green LR, Monk PN (2021) ACE2-independent interaction of SARS-CoV-2 spike protein with human epithelial cells is inhibited by unfractionated heparin. Cells 10:1419\u20131434","journal-title":"Cells"},{"key":"7_CR60","doi-asserted-by":"publisher","first-page":"104525","DOI":"10.1016\/j.meegid.2020.104525","volume":"85","author":"F Pereira","year":"2020","unstructured":"Pereira F (2020) Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene. Infect Genet Evol 85:104525\u2013104535","journal-title":"Infect Genet Evol"},{"key":"7_CR61","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1089\/omi.2023.0274","volume":"28","author":"S Rajoria","year":"2024","unstructured":"Rajoria S, Kavuru SR, Pyda HS, Bihani S, Borishetty D, Biswas D et al (2024) CoVProt: toward a mass spectrometry data portal for COVID-19 proteomics research and development. OMICS 28:24\u201331","journal-title":"OMICS"},{"key":"7_CR62","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/1346-8138.12076","volume":"40","author":"H Shimada","year":"2013","unstructured":"Shimada H, Nambu-Niibori A, Wilson-Morifuji M, Mizuguchi S, Araki N, Sumiyoshi H et al (2013) Epiplakin modifies the motility of the HeLa cells and accumulates at the outer surfaces of 3-D cell clusters. J Dermatol 40:249\u2013258","journal-title":"J Dermatol"},{"key":"7_CR63","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/s41423-023-01104-y","volume":"21","author":"BL Sievers","year":"2024","unstructured":"Sievers BL, Cheng MTK, Csiba K, Meng B, Gupta RK (2024) SARS-CoV-2 and innate immunity: the good, the bad, and the \"goldilocks\". Cell Mol Immunol 21:171\u2013183","journal-title":"Cell Mol Immunol"},{"key":"7_CR64","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s00018-011-0657-y","volume":"68","author":"EJ Sijts","year":"2011","unstructured":"Sijts EJ, Kloetzel PM (2011) The role of the proteasome in the generation of MHC class I ligands and immune responses. Cell Mol Life Sci 68:1491\u20131502","journal-title":"Cell Mol Life Sci"},{"key":"7_CR65","doi-asserted-by":"publisher","first-page":"20398","DOI":"10.1038\/s41598-021-99893-7","volume":"11","author":"P Simons","year":"2021","unstructured":"Simons P, Rinaldi DA, Bondu V, Kell AM, Bradfute S, Lidke DS et al (2021) Integrin activation is an essential component of SARS-CoV-2 infection. Sci Rep 11:20398\u201320409","journal-title":"Sci Rep"},{"key":"7_CR66","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41586-021-03493-4","volume":"594","author":"A Stukalov","year":"2021","unstructured":"Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C et al (2021) Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 594:246\u2013252","journal-title":"Nature"},{"key":"7_CR67","doi-asserted-by":"publisher","first-page":"109527","DOI":"10.1016\/j.celrep.2021.109527","volume":"36","author":"KD Sullivan","year":"2021","unstructured":"Sullivan KD, Galbraith MD, Kinning KT, Bartsch KW, Levinsky NC, Araya P et al (2021) The COVIDome explorer researcher portal. Cell Rep 36:109527\u2013109548","journal-title":"Cell Rep"},{"key":"7_CR68","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00512-20","volume":"58","author":"YW Tang","year":"2020","unstructured":"Tang YW, Schmitz JE, Persing DH, Stratton CW (2020) Laboratory diagnosis of COVID-19: current issues and challenges. J Clin Microbiol 58:e00512-20","journal-title":"J Clin Microbiol"},{"key":"7_CR69","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41579-020-00468-6","volume":"19","author":"P V\u2019kovski","year":"2021","unstructured":"V\u2019kovski P, Kratzel A, Steiner S, Stalder H, Thiel V (2021) Coronavirus biology and replication: implications for SARS-CoV-2. Nat Rev Microbiol 19:155\u2013170","journal-title":"Nat Rev Microbiol"},{"key":"7_CR70","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/nrmicro2146","volume":"7","author":"GR Vasta","year":"2009","unstructured":"Vasta GR (2009) Roles of galectins in infection. Nat Rev Microbiol 7:424\u2013438","journal-title":"Nat Rev Microbiol"},{"key":"7_CR71","first-page":"1","volume":"138","author":"BT Veenstra","year":"2024","unstructured":"Veenstra BT, Veenstra TD (2024) Proteomic applications in identifying protein-protein interactions. Adv Protein Chem Struct Biol 138:1\u201348","journal-title":"Adv Protein Chem Struct Biol"},{"key":"7_CR72","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.3390\/v13071346","volume":"13","author":"P Veluswamy","year":"2021","unstructured":"Veluswamy P, Wacker M, Stavridis D, Reichel T, Schmidt H, Scherner M et al (2021) The SARS-CoV-2\/receptor axis in heart and blood vessels: a crisp update on COVID-19 disease with cardiovascular complications. Viruses 13:1346\u20131379","journal-title":"Viruses"},{"key":"7_CR73","doi-asserted-by":"publisher","first-page":"e00127","DOI":"10.1128\/JVI.00127-20","volume":"94","author":"Y Wan","year":"2020","unstructured":"Wan Y, Shang J, Graham R, Baric RS, Li F (2020) Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol 94:e00127\u2013e00120","journal-title":"J Virol"},{"key":"7_CR74","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41392-020-00426-x","volume":"5","author":"K Wang","year":"2020","unstructured":"Wang K, Chen W, Zhang Z, Deng Y, Lian JQ, Du P et al (2020) CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells. Signal Transduct Target Ther 5:283\u2013292","journal-title":"Signal Transduct Target Ther"},{"key":"7_CR75","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12014-024-09452-1","volume":"21","author":"D Wenk","year":"2024","unstructured":"Wenk D, Zuo C, Kislinger T, Sepiashvili L (2024) Recent developments in mass-spectrometry-based targeted proteomics of clinical cancer biomarkers. Clin Proteomics 21:6\u201320","journal-title":"Clin Proteomics"},{"key":"7_CR76","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jmb.2009.07.079","volume":"393","author":"CP Xavier","year":"2009","unstructured":"Xavier CP, Rastetter RH, Stumpf M, Rosentreter A, M\u00fcller R, Reimann J et al (2009) Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. J Mol Biol 393:287\u2013299","journal-title":"J Mol Biol"},{"key":"7_CR77","doi-asserted-by":"publisher","first-page":"1011185","DOI":"10.3389\/fimmu.2022.1011185","volume":"13","author":"ST Yeung","year":"2022","unstructured":"Yeung ST, Premeaux TA, Du L, Niki T, Pillai SK, Khanna KM et al (2022) Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 infection. Front Immunol 13:1011185\u20131011196","journal-title":"Front Immunol"},{"key":"7_CR78","doi-asserted-by":"publisher","first-page":"582","DOI":"10.3390\/v12060582","volume":"12","author":"N Younes","year":"2020","unstructured":"Younes N, Al-Sadeq DW, Al-Jighefee H, Younes S, Al-Jamal O, Daas HI et al (2020) Challenges in laboratory diagnosis of the novel coronavirus SARS-CoV-2. Viruses 12:582\u2013608","journal-title":"Viruses"},{"key":"7_CR79","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1038\/s41467-018-05796-z","volume":"9","author":"HX Zhang","year":"2018","unstructured":"Zhang HX, Xu ZS, Lin H, Li M, Xia T, Cui K et al (2018) TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis. Nat Commun 9:3441\u20133456","journal-title":"Nat Commun"},{"key":"7_CR80","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1016\/j.ymthe.2022.02.014","volume":"30","author":"S Zhang","year":"2022","unstructured":"Zhang S, Wang L, Cheng G (2022) The battle between host and SARS-CoV-2: innate immunity and viral evasion strategies. Mol Ther 30:1869\u20131884","journal-title":"Mol Ther"},{"key":"7_CR81","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1021\/acs.jproteome.3c00092","volume":"22","author":"F Zhang","year":"2023","unstructured":"Zhang F, Luna A, Tan T, Chen Y, Sander C, Guo T (2023) COVIDpro: database for mining protein dysregulation in patients with COVID-19. J Proteome Res 22:2847\u20132859","journal-title":"J Proteome Res"},{"key":"7_CR82","doi-asserted-by":"publisher","first-page":"8752","DOI":"10.1021\/acs.analchem.2c05770","volume":"95","author":"W Zhou","year":"2023","unstructured":"Zhou W, Sui Z, Liu J, He Y, Yuan H, Sun Y et al (2023a) High-sensitivity detection toward SARS-CoV-2 S1 glycoprotein by parallel reaction monitoring mass spectrometry. Anal Chem 95:8752\u20138757","journal-title":"Anal Chem"},{"key":"7_CR83","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41587-022-01474-0","volume":"41","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Liu Y, Gupta S, Paramo MI, Hou Y, Mao C et al (2023b) A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Nat Biotechnol 41:128\u2013139","journal-title":"Nat Biotechnol"},{"key":"7_CR84","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMoa2001017","volume":"382","author":"N Zhu","year":"2020","unstructured":"Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382:727\u2013733","journal-title":"N Engl J Med"}],"container-title":["Advances in Experimental Medicine and Biology","Proteomic Applications in Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-22340-1_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:09:40Z","timestamp":1778713780000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-22340-1_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032223395","9783032223401"],"references-count":84,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-22340-1_7","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"1 May 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}