{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:10:30Z","timestamp":1778213430628,"version":"3.51.4"},"publisher-location":"Cham","reference-count":22,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032236036","type":"print"},{"value":"9783032236043","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-23604-3_18","type":"book-chapter","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:17:58Z","timestamp":1778210278000},"page":"282-295","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hybrid Modeling for Predicting the Evolution of Premalignant Cervical Squamous Lesions via Intelligent Agents and Deep Neural Networks"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-6852","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Bueno-Crespo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-9635","authenticated-orcid":false,"given":"Ana","family":"Ortiz-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-9933","authenticated-orcid":false,"given":"Jos\u00e9","family":"Mart\u00ednez-M\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-7549","authenticated-orcid":false,"given":"Carlos","family":"Cotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"18_CR1","volume":"372","author":"M Arbyn","year":"2021","unstructured":"Arbyn, M., Smith, S.B., Temin, S., Sultana, F., Castle, P.: Detecting cervical precancer and reaching under-screened women by using HPV testing on self samples: updated meta-analyses. BMJ 372, n482 (2021)","journal-title":"BMJ"},{"issue":"Suppl 3","key":"18_CR2","doi-asserted-by":"publisher","first-page":"7280","DOI":"10.1073\/pnas.082080899","volume":"99","author":"E Bonabeau","year":"2002","unstructured":"Bonabeau, E.: Agent-based modeling: methods and techniques for simulating human systems. Proc. Natl. Acad. Sci. 99(Suppl 3), 7280\u20137287 (2002)","journal-title":"Proc. Natl. Acad. Sci."},{"key":"18_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3210-1","volume-title":"Connectionist Speech Recognition: A Hybrid Approach","author":"HA Bourlard","year":"1994","unstructured":"Bourlard, H.A., Morgan, N.: Connectionist Speech Recognition: A Hybrid Approach. Kluwer Academic Publishers, Boston, MA (1994)"},{"key":"18_CR4","doi-asserted-by":"publisher","unstructured":"Portero de\u00a0la Cruz, S., Jes\u00fas, C.: Trends and determinants in uptake of cervical cancer screening in Spain: an analysis of national surveys from 2017 and 2020. Cancers (Basel) May 18;14(10), 2481 (2022). https:\/\/doi.org\/10.3390\/cancers14102481","DOI":"10.3390\/cancers14102481"},{"key":"18_CR5","unstructured":"Guo, C., Pleiss, G., Sun, Y., Weinberger, K.Q.: On calibration of modern neural networks. In: Proceedings of the 34th International Conference on Machine Learning (ICML), pp. 1321\u20131330 (2017)"},{"issue":"10","key":"18_CR6","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1002\/cam4.4470","volume":"11","author":"R Ikesu","year":"2022","unstructured":"Ikesu, R., et al.: A hidden Markov model analysis of a single-center cohort of high-risk HPV-infected cervical lesions. Cancer Med. 11(10), 2056\u20132066 (2022). https:\/\/doi.org\/10.1002\/cam4.4470","journal-title":"Cancer Med."},{"key":"18_CR7","unstructured":"Krishnan, R.G., Shalit, U., Sontag, D.: Structured inference networks for nonlinear state space models. In: Proceedings of the Thirty-First AAAI Conference on Artificial Intelligence (AAAI-17), pp. 2101\u20132109 (2017). https:\/\/arxiv.org\/abs\/1609.09869"},{"issue":"3","key":"18_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1057\/jos.2010.3","volume":"4","author":"CM Macal","year":"2010","unstructured":"Macal, C.M., North, M.J.: Tutorial on agent-based modeling and simulation. J. Simul. 4(3), 151\u2013162 (2010)","journal-title":"J. Simul."},{"issue":"5","key":"18_CR9","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1109\/5.381844","volume":"83","author":"N Morgan","year":"1995","unstructured":"Morgan, N., Bourlard, H.A.: Neural networks for statistical recognition of continuous speech. Proc. IEEE 83(5), 741\u2013770 (1995)","journal-title":"Proc. IEEE"},{"key":"18_CR10","unstructured":"National Cancer Institute: Cervical cancer prognosis and survival rates (Apr 2023), https:\/\/www.cancer.gov\/types\/cervical\/survival, [Accessed 06-09-2023]"},{"key":"18_CR11","unstructured":"National Cancer Institute: Cervical cancer screening (pdq\u00ae)\u2014patient version. https:\/\/www.cancer.gov\/types\/cervical\/patient\/cervical-screening-pdq (2023). Accessed 20 Oct 2025"},{"issue":"4\u20135","key":"18_CR12","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1159\/000477556","volume":"61","author":"R Nayar","year":"2017","unstructured":"Nayar, R., Wilbur, D.C.: The Bethesda system for reporting cervical cytology: a historical perspective. Acta Cytol. 61(4\u20135), 359\u2013372 (2017). https:\/\/doi.org\/10.1159\/000477556","journal-title":"Acta Cytol."},{"key":"18_CR13","unstructured":"of\u00a0Obstetricians, A.C., Gynecologists: Updated cervical cancer screening guidelines. Practice Advisory (2021). https:\/\/www.acog.org\/clinical\/clinical-guidance\/practice-advisory\/articles\/2021\/04\/updated-cervical-cancer-screening-guidelines"},{"key":"18_CR14","unstructured":"Organization, W.H.: Who guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention. World Health Organization (2021). https:\/\/www.who.int\/publications\/i\/item\/9789240040434"},{"key":"18_CR15","doi-asserted-by":"publisher","unstructured":"Pangarkar, M.A., Pillai, Y., Shah, S., Sharma, M.: The Bethesda system for reporting cervical cytology. J. Cytol. 39(3), 119\u2013126 (2022). https:\/\/doi.org\/10.4103\/JOC.JOC_213_20, https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9168399\/","DOI":"10.4103\/JOC.JOC_213_20"},{"issue":"2","key":"18_CR16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/LGT.0000000000000525","volume":"24","author":"RB Perkins","year":"2020","unstructured":"Perkins, R.B., Guido, R.S., Castle, P.E., et al.: 2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors. J. Low. Genit. Tract Dis. 24(2), 102\u2013131 (2020)","journal-title":"J. Low. Genit. Tract Dis."},{"issue":"2","key":"18_CR17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1109\/5.18626","volume":"77","author":"LR Rabiner","year":"1989","unstructured":"Rabiner, L.R.: A tutorial on hidden Markov models and selected applications in speech recognition. Proc. IEEE 77(2), 257\u2013286 (1989)","journal-title":"Proc. IEEE"},{"key":"18_CR18","doi-asserted-by":"publisher","unstructured":"Sukkar, R., Katz, E., Zhang, Y., Raunig, D., Wyman, B.T.: Disease progression modeling using hidden Markov models. In: Proceedings of the 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 2845\u20132848 (2012). https:\/\/doi.org\/10.1109\/EMBC.2012.6346556","DOI":"10.1109\/EMBC.2012.6346556"},{"key":"18_CR19","doi-asserted-by":"publisher","unstructured":"Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., Bray, F.: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209\u2013249 (2021). https:\/\/doi.org\/10.3322\/caac.21660, https:\/\/doi.org\/10.3322\/caac.21660. [Accessed 06 Sept 2023]","DOI":"10.3322\/caac.21660"},{"issue":"2","key":"18_CR20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3390\/cancers12020270","volume":"12","author":"A Taguchi","year":"2020","unstructured":"Taguchi, A., et al.: Multistate Markov model to predict the prognosis of high-risk human papillomavirus-related cervical lesions. Cancers 12(2), 270 (2020). https:\/\/doi.org\/10.3390\/cancers12020270","journal-title":"Cancers"},{"key":"18_CR21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1146\/annurev-publhealth-040617-014317","volume":"39","author":"M Tracy","year":"2018","unstructured":"Tracy, M., Cerd\u00e1, M., Keyes, K.M.: Agent-based modeling in public health: current applications and future directions. Annu. Rev. Public Health 39, 77\u201394 (2018). https:\/\/doi.org\/10.1146\/annurev-publhealth-040617-014317","journal-title":"Annu. Rev. Public Health"},{"key":"18_CR22","unstructured":"World Health Organization: Cervical cancer \u2014 who.int. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cervical-cancer (2022). [Accessed 06 Sept 2023]"}],"container-title":["Lecture Notes in Computer Science","Applications of Evolutionary Computation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-23604-3_18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:19:44Z","timestamp":1778210384000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-23604-3_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032236036","9783032236043"],"references-count":22,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-23604-3_18","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"9 May 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure of Interests"}},{"value":"EvoApplications","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on the Applications of Evolutionary Computation (Part of EvoStar)","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Toulouse","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"France","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2026","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"8 April 2026","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"10 April 2026","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"29","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"evoapplications2026","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/www.evostar.org\/2026\/evoapps\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}