{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:05:25Z","timestamp":1789646725541,"version":"4.0.0"},"publisher-location":"Cham","reference-count":91,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032241580","type":"print"},{"value":"9783032241597","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-24159-7_6","type":"book-chapter","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:57:28Z","timestamp":1789646248000},"page":"119-146","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Confined Water Organization\u00a0in the Fluid Phase of Phospholipid Self-Assemblies: The Three-Water Layer Model"],"prefix":"10.1007","author":[{"given":"Gerome","family":"Vancuylenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Brocklehurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Sadeghpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon D.","family":"Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwen I. I.","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rappolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"6_CR1","doi-asserted-by":"publisher","first-page":"E1609","DOI":"10.1073\/pnas.1119442109","volume":"109","author":"S Aeffner","year":"2012","unstructured":"Aeffner S, Reusch T, Weinhausen B, Salditt T (2012) Energetics of stalk intermediates in membrane fusion are controlled by lipid composition. Proc Natl Acad Sci USA 109:E1609\u2013E1618","journal-title":"Proc Natl Acad Sci USA"},{"key":"6_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jelechem.2003.10.030","volume":"564","author":"SA Akimov","year":"2004","unstructured":"Akimov SA, Kuzmin PI, Zimmerberg J, Cohen FS, Chizmadzhev YA (2004) An elastic theory for line tension at a boundary separating two lipid monolayer regions of different thickness. J Electroanal Chem 564:13\u201318","journal-title":"J Electroanal Chem"},{"key":"6_CR3","volume-title":"Molecular biology of the cell","author":"B Alberts","year":"2008","unstructured":"Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2008) Molecular biology of the cell, 5th edn. Taylor & Francis Group, New York","edition":"5"},{"key":"6_CR4","doi-asserted-by":"publisher","first-page":"5547","DOI":"10.1063\/1.465947","volume":"99","author":"HE Alper","year":"1993","unstructured":"Alper HE, Bassolino-Klimas D, Stouch TR (1993) The limiting behavior of water hydrating a phospholipid monolayer: a computer simulation study. J Chem Phys 99:5547\u20135559","journal-title":"J Chem Phys"},{"key":"6_CR5","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1002\/cphc.200900185","volume":"10","author":"Z Arsov","year":"2009","unstructured":"Arsov Z, Rappolt M, Grdadolnik J (2009) Weakened hydrogen bonds in water confined between lipid bilayers: the existence of a long-range attractive hydration force. Chemphyschem 10:1438\u20131441","journal-title":"Chemphyschem"},{"key":"6_CR6","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.3390\/nu7042731","volume":"7","author":"CN Blesso","year":"2015","unstructured":"Blesso CN (2015) Egg phospholipids and cardiovascular health. Nutrients 7:2731\u20132747","journal-title":"Nutrients"},{"key":"6_CR7","volume-title":"Structure data of free polyatomic molecules\/Strukturdaten freier mehratomiger Molekeln","author":"I Buck","year":"1976","unstructured":"Buck I, Callomon JH, Hellwege KH, Starck B, Hirota E, Hellwege AM, Kuchitsu K, Lafferty WJ, Maki AG, Pote CS (1976) Structure data of free polyatomic molecules\/Strukturdaten freier mehratomiger Molekeln. Springer Berlin Heidelberg"},{"key":"6_CR8","first-page":"891","volume":"274","author":"A Caill\u00e9","year":"1972","unstructured":"Caill\u00e9 A (1972) Remarques sur la diffusion des rayons X dans les smectiques A. CR Acad Sc Paris B 274:891\u2013893","journal-title":"CR Acad Sc Paris B"},{"key":"6_CR9","doi-asserted-by":"publisher","first-page":"6050","DOI":"10.1021\/acs.jctc.8b00496","volume":"14","author":"TS Carpenter","year":"2018","unstructured":"Carpenter TS, L\u00f3pez CA, Neale C, Montour C, Ing\u00f3lfsson HI, Di Natale F, Lightstone FC, Gnanakaran S (2018) Capturing phase behavior of ternary lipid mixtures with a refined martini coarse-grained force field. J Chem Theory Comput 14:6050\u20136062","journal-title":"J Chem Theory Comput"},{"key":"6_CR10","doi-asserted-by":"publisher","DOI":"10.1021\/ed058pA246.1","volume":"58","author":"S Clarke","year":"1981","unstructured":"Clarke S (1981) The hydrophobic effect: formation of micelles and biological membranes, 2nd edition (Tanford, Charles). J Chem Educ 58:A264","journal-title":"J Chem Educ"},{"key":"6_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/membranes15020046","volume":"15","author":"V Conti Nibali","year":"2025","unstructured":"Conti Nibali V, Branca C, Wanderlingh U, Verduci R, Bonaccorso E, Ciccolo A, D\u2019Angelo G (2025) Insights on hydrogen bond network of water in phospholipid membranes: an infrared study at varying hydration. Membranes 15:Art. no. 46","journal-title":"Membranes"},{"key":"6_CR12","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1021\/jp073897w","volume":"112","author":"A Cordom\u00ed","year":"2008","unstructured":"Cordom\u00ed A, Edholm O, Perez JJ (2008) Effect of ions on a dipalmitoyl phosphatidylcholine bilayer. A molecular dynamics simulation study. J Phys Chem B 112:1397\u20131408","journal-title":"J Phys Chem B"},{"key":"6_CR13","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.1002\/aic.14909","volume":"61","author":"G Das","year":"2015","unstructured":"Das G, Hlushak S, dos Ramos MC, McCabe C (2015) Predicting the thermodynamic properties and dielectric behavior of electrolyte solutions using the SAFT-VR+DE equation of state. AICHE J 61:3053\u20133072","journal-title":"AICHE J"},{"key":"6_CR14","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.bpj.2018.12.016","volume":"116","author":"M Doktorova","year":"2019","unstructured":"Doktorova M, LeVine MV, Khelashvili G, Weinstein H (2019) A new computational method for membrane compressibility: bilayer mechanical thickness revisited. Biophys J 116:487\u2013502","journal-title":"Biophys J"},{"key":"6_CR15","first-page":"1","volume-title":"New Compr Biochem","author":"W Dowhan","year":"2002","unstructured":"Dowhan W, Bogdanov M (2002) Chapter 1: Functional roles of Lipdids in membranes. In: New Compr Biochem, vol 36, pp 1\u201335"},{"key":"6_CR16","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.3390\/sym13081441","volume":"13","author":"MPK Frewein","year":"2021","unstructured":"Frewein MPK, Doktorova M, Heberle FA, Scott HL, Semeraro EF, Porcar L, Pabst G (2021) Structure and interdigitation of chain-asymmetric phosphatidylcholines and milk sphingomyelin in the fluid phase. Symmetry 13:1441","journal-title":"Symmetry"},{"key":"6_CR17","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.1016\/S0006-3495(03)74816-4","volume":"85","author":"M Ge","year":"2003","unstructured":"Ge M, Freed JH (2003) Hydration, structure, and molecular interactions in the Headgroup Region of Dioleoylphosphatidylcholine bilayers: an electron spin resonance study. Biophys J 85:4023\u20134040","journal-title":"Biophys J"},{"key":"6_CR18","doi-asserted-by":"publisher","first-page":"10167","DOI":"10.1073\/pnas.93.19.10167","volume":"93","author":"M Gerstein","year":"1996","unstructured":"Gerstein M, Chothia C (1996) Packing at the protein-water interface. Proc Natl Acad Sci USA 93:10167\u201310172","journal-title":"Proc Natl Acad Sci USA"},{"key":"6_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.electacta.2013.07.147","volume":"126","author":"E Gongadze","year":"2014","unstructured":"Gongadze E, Velikonja A, Perutkova \u0160, Kramar P, Ma\u010dek-Lebar A, Kralj-Igli\u010d V, Igli\u010d A (2014) Ions and water molecules in an electrolyte solution in contact with charged and dipolar surfaces. Electrochim Acta 126:42\u201360","journal-title":"Electrochim Acta"},{"key":"6_CR20","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1016\/j.bpj.2010.09.064","volume":"99","author":"FA Heberle","year":"2010","unstructured":"Heberle FA, Wu J, Goh SL, Petruzielo RS, Feigenson GW (2010) Comparison of three ternary lipid bilayer mixtures: FRET and ESR reveal nanodomains. Biophys J 99:3309\u20133318","journal-title":"Biophys J"},{"key":"6_CR21","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1107\/S1600576713029798","volume":"47","author":"P Heftberger","year":"2014","unstructured":"Heftberger P, Kollmitzer B, Heberle FA, Pan J, Rappolt M, Amenitsch H, Ku\u010derka N, Katsaras J, Pabst G (2014) Global small-angle X-ray scattering data analysis for multilamellar vesicles: the evolution of the scattering density profile model. J Appl Crystallogr 47:173\u2013180","journal-title":"J Appl Crystallogr"},{"key":"6_CR22","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.bpj.2014.11.3488","volume":"108","author":"P Heftberger","year":"2015","unstructured":"Heftberger P, Kollmitzer B, Rieder Alexander A, Amenitsch H, Pabst G (2015) In situ determination of structure and fluctuations of coexisting fluid membrane domains. Biophys J 108:854\u2013862","journal-title":"Biophys J"},{"key":"6_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/BF02452208","volume":"3","author":"W Helfrich","year":"1984","unstructured":"Helfrich W, Servuss RM (1984) Undulations, steric interaction and cohesion of fluid membranes. Il Nuovo Cimento D 3:137\u2013151","journal-title":"Il Nuovo Cimento D"},{"key":"6_CR24","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1119\/1.1932852","volume":"19","author":"G Herzberg","year":"1951","unstructured":"Herzberg G (1951) Molecular spectra and molecular structure. I. spectra of diatomic molecules. Am J Phys 19:390\u2013391","journal-title":"Am J Phys"},{"key":"6_CR25","volume-title":"Intermolecular and surface forces","author":"J Israelachvili","year":"2011","unstructured":"Israelachvili J (2011) Intermolecular and surface forces, 3rd edn. Academic, London","edition":"3"},{"key":"6_CR26","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0955-2863(96)00118-0","volume":"7","author":"GL Jendrasiak","year":"1996","unstructured":"Jendrasiak GL (1996) The hydration of phospholipids and its biological significance. J Nutr Biochem 7:599\u2013609","journal-title":"J Nutr Biochem"},{"key":"6_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263119","volume":"17","author":"MAS Karal","year":"2022","unstructured":"Karal MAS, Mokta NA, Levadny V, Belaya M, Ahmed M, Ahamed MK, Ahammed S (2022) Effects of cholesterol on the size distribution and bending modulus of lipid vesicles. PLoS One 17:e0263119","journal-title":"PLoS One"},{"key":"6_CR28","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1021\/ja200310d","volume":"133","author":"PM Kasson","year":"2011","unstructured":"Kasson PM, Lindahl E, Pande VS (2011) Water ordering at membrane interfaces controls fusion dynamics. J Am Chem Soc 133:3812\u20133815","journal-title":"J Am Chem Soc"},{"key":"6_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctta.2022.100053","volume":"6","author":"GM Kontogeorgis","year":"2022","unstructured":"Kontogeorgis GM, Holster A, Kottaki N, Tsochantaris E, Tops\u00f8e F, Poulsen J, Bache M, Liang X, Blom NS, Kronholm J (2022) Water structure, properties and some applications\u2014a review. Chem Thermodyn Ther Anal 6:100053","journal-title":"Chem Thermodyn Ther Anal"},{"key":"6_CR30","first-page":"121","volume":"30","author":"SS Korreman","year":"2001","unstructured":"Korreman SS, Posselt D (2001) Modification of anomalous swelling in multilamellar vesicles induced by alkali halide salts. EurBiophysJ 30:121\u2013128","journal-title":"EurBiophysJ"},{"key":"6_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bioelechem.2016.04.006","volume":"111","author":"AM Lebar","year":"2016","unstructured":"Lebar AM, Velikonja A, Kramar P, Igli\u010d A (2016) Internal configuration and electric potential in planar negatively charged lipid head group region in contact with ionic solution. Bioelectrochemistry 111:49\u201356","journal-title":"Bioelectrochemistry"},{"key":"6_CR32","doi-asserted-by":"publisher","DOI":"10.1063\/1.5120456","volume":"151","author":"E Lee","year":"2019","unstructured":"Lee E, Kundu A, Jeon J, Cho M (2019) Water hydrogen-bonding structure and dynamics near lipid multibilayer surface: molecular dynamics simulation study with direct experimental comparison. J Chem Phys 151:114705","journal-title":"J Chem Phys"},{"key":"6_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0079-6816(73)90003-8","volume":"3","author":"YK Levine","year":"1973","unstructured":"Levine YK (1973) X-ray diffraction studies of membranes. Progr Surf Sci 3:279\u2013352","journal-title":"Progr Surf Sci"},{"key":"6_CR34","first-page":"69","volume":"84","author":"NYD Li","year":"2017","unstructured":"Li NYD, Perutkov\u00e1 \u0160, Igli\u010d A, Rappolt M (2017) My first electron density map: a beginner's guide to small angle X-ray diffraction. Elektrotehniski Vestnik\/Electrotechnical Review 84:69\u201375","journal-title":"Elektrotehniski Vestnik\/Electrotechnical Review"},{"key":"6_CR35","volume-title":"Structure and dynamics of membranes. From cells to vesicles","author":"R Lipowsky","year":"1995","unstructured":"Lipowsky R, Sackmann E (1995) Structure and dynamics of membranes. From cells to vesicles. Elsevier, Amsterdam"},{"key":"6_CR36","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1021\/bi00510a010","volume":"20","author":"LJ Lis","year":"1981","unstructured":"Lis LJ, Lis WT, Parsegian VA, Rand RP (1981) Adsorption of divalent cations to a variety of phosphatidylcholine bilayers. Biochemistry 20:1771\u20131777","journal-title":"Biochemistry"},{"key":"6_CR37","first-page":"527","volume-title":"Bioelectrochemistry: ions, surfaces, membranes","author":"LJ Lis","year":"1980","unstructured":"Lis LJ, Rand RP, Parsegian VA (1980) Measurement of the adsorption of Ca2+ and Mg2+ to Phosphatidyl choline bilayers. In: Blank M (ed) Bioelectrochemistry: ions, surfaces, membranes, vol 188. ACS Publications, Washington, p 527"},{"key":"6_CR38","doi-asserted-by":"publisher","first-page":"6603","DOI":"10.1021\/jp037618q","volume":"108","author":"CF Lopez","year":"2004","unstructured":"Lopez CF, Nielsen SO, Klein ML, Moore PB (2004) Hydrogen bonding structure and dynamics of water at the Dimyristoylphosphatidylcholine lipid bilayer surface from a molecular dynamics simulation. J Phys Chem B 108:6603\u20136610","journal-title":"J Phys Chem B"},{"key":"6_CR39","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1083\/jcb.12.2.207","volume":"12","author":"V Luzzati","year":"1962","unstructured":"Luzzati V, Husson F (1962) The structure of the liquid-crystalline phases of lipid-water systems. J Cell Biol 12:207\u2013219","journal-title":"J Cell Biol"},{"key":"6_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s11467-017-0704-8","volume":"13","author":"F Martelli","year":"2017","unstructured":"Martelli F, Ko H-Y, Borallo CC, Franzese G (2017) Structural properties of water confined by phospholipid membranes. Front Phys 13:136801","journal-title":"Front Phys"},{"key":"6_CR41","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0009-3084(96)02577-7","volume":"81","author":"TJ McIntosh","year":"1996","unstructured":"McIntosh TJ (1996) Hydration properties of lamellar and non-lamellar phases of phosphatidylcholine and phosphatidylethanolamine. Chem Phys Lipids 81:117\u2013131","journal-title":"Chem Phys Lipids"},{"key":"6_CR42","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.1021\/bi00365a034","volume":"25","author":"TJ McIntosh","year":"1986","unstructured":"McIntosh TJ, Simon SA (1986a) Area per molecule and distribution of water in fully hydrated dilauroylphosphatidylethanolamine bilayers. Biochemistry 25:4948\u20134952","journal-title":"Biochemistry"},{"key":"6_CR43","first-page":"4058","volume":"25","author":"TJ McIntosh","year":"1986","unstructured":"McIntosh TJ, Simon SA (1986b) Hydration force and bilayer deformation: a reevaluation. Biophys J 25:4058\u20134066","journal-title":"Biophys J"},{"key":"6_CR44","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1146\/annurev.bb.23.060194.000331","volume":"23","author":"TJ McIntosh","year":"1994","unstructured":"McIntosh TJ, Simon SA (1994) Hydration and steric pressures between phospholipid bilayers 1. Annu Rev Biophys Biomol Struct 23:27\u201351","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"6_CR45","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1021\/la950833g","volume":"12","author":"TJ McIntosh","year":"1996","unstructured":"McIntosh TJ, Simon SA (1996) Adhesion between phophatidylethanolmaine bilayers. Langmuir 12:1622\u20131630","journal-title":"Langmuir"},{"key":"6_CR46","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0304-4157(00)00016-2","volume":"1469","author":"JF Nagle","year":"2000","unstructured":"Nagle JF, Tristram-Nagle S (2000) Structure of lipid bilayers. Biochim Biophys Acta-Rev Biomembr 1469:159\u2013195","journal-title":"Biochim Biophys Acta-Rev Biomembr"},{"key":"6_CR47","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/S0006-3495(96)79701-1","volume":"70","author":"JF Nagle","year":"1996","unstructured":"Nagle JF, Zhang R, Tristram-Nagle S, Sun W, Petrache HI, Suter RM (1996) X-ray structure determination of fully hydrated L alpha phase dipalmitoylphosphatidylcholine bilayers. Biophys J 70:1419\u20131431","journal-title":"Biophys J"},{"key":"6_CR48","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.chemphyslip.2015.07.012","volume":"192","author":"JD Nickels","year":"2015","unstructured":"Nickels JD, Smith JC, Cheng XL (2015) Lateral organization, bilayer asymmetry, and inter-leaflet coupling of biological membranes. Chem Phys Lipids 192:87\u201399","journal-title":"Chem Phys Lipids"},{"key":"6_CR49","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1142\/S1793048006000069","volume":"1","author":"G Pabst","year":"2006","unstructured":"Pabst G (2006) Global properties of biomimetic membranes: perspectives on molecular features. Biophys Rev Lett 1:57\u201384","journal-title":"Biophys Rev Lett"},{"key":"6_CR50","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1529\/biophysj.107.112615","volume":"93","author":"G Pabst","year":"2007","unstructured":"Pabst G, Hodzic A, S\u00a6\u00eetrancar J, Danner S, Rappolt M, Laggner P (2007) Rigidification of neutral lipid bilayers in the presence of salts. Biophys J 93:2688\u20132696","journal-title":"Biophys J"},{"key":"6_CR51","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1107\/S0021889803017527","volume":"63","author":"G Pabst","year":"2003","unstructured":"Pabst G, Koschuch R, Pozo-Navas B, Rappolt M, Lohner K, Laggner P (2003) Structural analysis of weakly ordered membrane stacks. J Appl Crystallogr 63:1378\u20131388","journal-title":"J Appl Crystallogr"},{"key":"6_CR52","doi-asserted-by":"publisher","first-page":"4000","DOI":"10.1103\/PhysRevE.62.4000","volume":"62","author":"G Pabst","year":"2000","unstructured":"Pabst G, Rappolt M, Amenitsch H, Laggner P (2000a) Structural information from multilamellar liposomes at full hydration: full q-range fitting with high quality X-ray data. Phys Rev E 62:4000\u20134009","journal-title":"Phys Rev E"},{"key":"6_CR53","doi-asserted-by":"publisher","first-page":"4000","DOI":"10.1103\/PhysRevE.62.4000","volume":"62","author":"G Pabst","year":"2000","unstructured":"Pabst G, Rappolt M, Amenitsch H, Laggner P (2000b) Structural information from multilamellar liposomes at full hydration: full q-range fitting with high quality x-ray data. Phys Rev E 62:4000\u20134009","journal-title":"Phys Rev E"},{"key":"6_CR54","first-page":"643","volume-title":"Structure and dynamics of membranes","author":"VA Parsegian","year":"1995","unstructured":"Parsegian VA, Rand RP (1995) Interaction in membrane assemblies. In: Lipowsky R, Sackmann E (eds) Structure and dynamics of membranes. North-Holland, Amsterdam, pp 643\u2013690"},{"key":"6_CR55","first-page":"3677","volume":"101","author":"M Pasenkiewicz-Gierula","year":"1997","unstructured":"Pasenkiewicz-Gierula M, Takaoka Y, Miyagawa H, Kitamura K, Kusumi A (1997) Hydrogen bonding of water to phosphatidylcholine in the membrane as studied by a molecular dynamics simulation: location, geometry, and lipid\u2212lipid bridging via hydrogen-bonded water. Chem A Eur J 101:3677\u20133691","journal-title":"Chem A Eur J"},{"key":"6_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF02125760","volume":"228","author":"W Pechhold","year":"1968","unstructured":"Pechhold W (1968) Molek\u00fclbewegung in Polymeren. Kolloid-Zeitschrift und Zeitschrift f\u00fcr Polymere 228:1\u201338","journal-title":"Kolloid-Zeitschrift und Zeitschrift f\u00fcr Polymere"},{"key":"6_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183489","volume":"1863","author":"HA P\u00e9rez","year":"2021","unstructured":"P\u00e9rez HA, Alarc\u00f3n LM, Verde AR, Appignanesi GA, Gim\u00e9nez RE, Disalvo EA, Fr\u00edas MA (2021) Effect of cholesterol on the hydration properties of ester and ether lipid membrane interphases. Biochim Biophys Acta (BBA) \u2013 Biomembr 1863:183489","journal-title":"Biochim Biophys Acta (BBA) \u2013 Biomembr"},{"key":"6_CR58","doi-asserted-by":"publisher","first-page":"7014","DOI":"10.1103\/PhysRevE.57.7014","volume":"57","author":"HI Petrache","year":"1998","unstructured":"Petrache HI, Gouliaev N, Tristram-Nagle S, Zhang RT, Suter RM, Nagle JF (1998a) Interbilayer interactions from high-resolution x-ray scattering. Phys Rev E 57:7014\u20137024","journal-title":"Phys Rev E"},{"key":"6_CR59","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1194\/jlr.M500401-JLR200","volume":"47","author":"HI Petrache","year":"2006","unstructured":"Petrache HI, Tristram-Nagle S, Harries D, Ku\u0109erka N, Nagle JF, Parsegian VA (2006) Swelling of phospholipids by monovalent salt. J Lipid Res 47:302\u2013309","journal-title":"J Lipid Res"},{"key":"6_CR60","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0009-3084(98)00068-1","volume":"95","author":"HI Petrache","year":"1998","unstructured":"Petrache HI, Tristram-Nagle S, Nagle JF (1998b) Fluid phase structure of EPC and DMPC bilayers. Chem Phys Lipids 95:83\u201394","journal-title":"Chem Phys Lipids"},{"key":"6_CR61","first-page":"351","volume":"988","author":"RP Rand","year":"1989","unstructured":"Rand RP, Parsegian VA (1989) Hydration forces between phospholipid bilayers. BiochimBiophysActa 988:351\u2013376","journal-title":"BiochimBiophysActa"},{"key":"6_CR62","doi-asserted-by":"publisher","first-page":"084701","DOI":"10.1063\/1.3393600","volume":"107","author":"M Rappolt","year":"2010","unstructured":"Rappolt M (2010) Bilayer thickness estimations with \u201cpoor\u201d diffraction data. J Appl Phys 107:084701","journal-title":"J Appl Phys"},{"key":"6_CR63","first-page":"1","volume-title":"Advances in biomembranes and lipid self-assembly","author":"M Rappolt","year":"2019","unstructured":"Rappolt M (2019) 50 years of structural lipid bilayer modelling. In: Advances in biomembranes and lipid self-assembly, vol 29, pp 1\u201321"},{"key":"6_CR64","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.chemphyslip.2008.02.006","volume":"154","author":"M Rappolt","year":"2008","unstructured":"Rappolt M, Hodzic A, Sartori B, Ollivon M, Laggner P (2008) Conformational and hydrational properties during the L\u03b2- to L\u03b1- and L\u03b1- to HII-phase transition in phosphatidylethanolamine. Chem Phys Lipids 154:46\u201355","journal-title":"Chem Phys Lipids"},{"key":"6_CR65","unstructured":"Rappolt M, Laggner P, Pabst G (2004) Structure and elasticity of phospholipid bilayers in the L\u03b1 phase: a comparison of phosphatidylcholine and phosphatidylethanolamine membranes. In: Pandalai SG (ed) Recent research developments in biophysics, vol 3, Part II. Transworld Research Network, Trivandrum, pp 365\u2013394"},{"key":"6_CR66","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/9780470388495.ch3","volume-title":"Structure and dynamics of membranous interfaces","author":"M Rappolt","year":"2008","unstructured":"Rappolt M, Pabst G (2008) Flexibility and structure of fluid bilayer interfaces. In: Nag K (ed) Structure and dynamics of membranous interfaces. Wiley, Hoboken, pp 45\u201381"},{"key":"6_CR67","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1002\/bbpc.19961000710","volume":"100","author":"M Rappolt","year":"1996","unstructured":"Rappolt M, Rapp G (1996) Simultaneous small- and wide-angle x-ray diffraction during the main transition of dimyristoylphosphatidylethanolamine. Ber Bunsenges Phys Chem 100:1153\u20131162","journal-title":"Ber Bunsenges Phys Chem"},{"key":"6_CR68","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00249-002-0253-z","volume":"31","author":"M Rappolt","year":"2003","unstructured":"Rappolt M, Vidal MF, Kriechbaum M, Steinhart M, Amenitsch H, Bernstorff S, Laggner P (2003) Structural, dynamic and mechanical properties of POPC at low cholesterol concentration studied in pressure\/temperature space. Eur Biophys J Biophys Lett 31:575\u2013585","journal-title":"Eur Biophys J Biophys Lett"},{"key":"6_CR69","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/S0006-3495(00)76295-3","volume":"79","author":"W Rawicz","year":"2000","unstructured":"Rawicz W, Olbrich KC, McIntosh T, Needham D, Evans E (2000) Effect of chain length and unsaturation on elasticity of lipid bilayers. Biophys J 79:328\u2013339","journal-title":"Biophys J"},{"key":"6_CR70","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41565-019-0415-0","volume":"14","author":"L Salvati Manni","year":"2019","unstructured":"Salvati Manni L, Assenza S, Duss M, Vallooran JJ, Juranyi F, Jurt S, Zerbe O, Landau EM, Mezzenga R (2019) Soft biomimetic nanoconfinement promotes amorphous water over ice. Nat Nanotechnol 14:609\u2013615","journal-title":"Nat Nanotechnol"},{"key":"6_CR71","doi-asserted-by":"publisher","first-page":"4839","DOI":"10.1021\/bi00720a024","volume":"13","author":"A Seelig","year":"1974","unstructured":"Seelig A, Seelig J (1974) The dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance. Biochemistry 13:4839\u20134845","journal-title":"Biochemistry"},{"key":"6_CR72","doi-asserted-by":"publisher","first-page":"S1105","DOI":"10.1088\/0953-8984\/18\/28\/S01","volume":"18","author":"GC Shearman","year":"2006","unstructured":"Shearman GC, Ces O, Templer RH, Seddon JM (2006) Inverse lyotropic phases of lipids and membrane curvature. J Phys Condens Matter 18:S1105\u2013S1124","journal-title":"J Phys Condens Matter"},{"key":"6_CR73","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/0076-6879(86)27041-X","volume":"127","author":"SA Simon","year":"1986","unstructured":"Simon SA, McIntosh TJ (1986) Depth of water penetration into lipid bilayers. Methods Enzymol 127:511\u2013521","journal-title":"Methods Enzymol"},{"key":"6_CR74","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.str.2024.10.020","volume":"33","author":"C Soteriou","year":"2025","unstructured":"Soteriou C, Xu M, Connell SD, Tyler AII, Kalli AC, Thorne JL (2025) Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane. Structure 33:181\u2013195.e185","journal-title":"Structure"},{"key":"6_CR75","first-page":"8460","volume":"35","author":"R Subramaniam","year":"2019","unstructured":"Subramaniam R, Lynch S, Cen Y, Balaz S (2019) Polarity of hydrated phosphatidylcholine headgroups. Langmuir 35:8460\u20138471","journal-title":"Langmuir"},{"key":"6_CR76","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1126\/science.653353","volume":"200","author":"C Tanford","year":"1978","unstructured":"Tanford C (1978) The hydrophobic effect and the organization of living matter. Science 200:1012\u20131018","journal-title":"Science"},{"key":"6_CR77","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0022-5193(76)90129-6","volume":"62","author":"J Torbet","year":"1976","unstructured":"Torbet J, Wilkins MHF (1976) X-ray diffraction studies of lecithin bilayers. J Theor Biol 62:447\u2013458","journal-title":"J Theor Biol"},{"key":"6_CR78","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-3-319-19060-0_2","volume-title":"Membrane hydration","author":"S Tristram-Nagle","year":"2015","unstructured":"Tristram-Nagle S (2015) Use of X-ray and neutron scattering methods with volume measurements to determine lipid bilayer structure and number of water molecules\/lipid. In: Disalvo EA (ed) Membrane hydration. Springer, pp 17\u201343"},{"key":"6_CR79","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S0006-3495(96)79623-6","volume":"70","author":"K Tu","year":"1996","unstructured":"Tu K, Tobias DJ, Blasie JK, Klein ML (1996) Molecular dynamics investigation of the structure of a fully hydrated gel-phase dipalmitoylphosphatidylcholine bilayer. Biophys J 70:595\u2013608","journal-title":"Biophys J"},{"key":"6_CR80","unstructured":"Vancuylenberg G (2024) The organisation of confined water in self-assembled lipid nanostructures school of food science & nutrition, vol PhD. University of Leeds, p 136"},{"key":"6_CR81","doi-asserted-by":"publisher","first-page":"8519","DOI":"10.1039\/D3SM01029E","volume":"19","author":"G Vancuylenberg","year":"2023","unstructured":"Vancuylenberg G, Sadeghpour A, Tyler AII, Rappolt M (2023a) From angular to round: in depth interfacial analysis of binary phosphatidylethanolamine mixtures in the inverse hexagonal phase. Soft Matter 19:8519\u20138530","journal-title":"Soft Matter"},{"key":"6_CR82","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.1039\/D3SM00387F","volume":"19","author":"G Vancuylenberg","year":"2023","unstructured":"Vancuylenberg G, Sadeghpour A, Tyler AII, Rappolt M (2023b) Planar confined water organisation in lipid bilayer stacks of phosphatidylcholine and phosphatidylethanolamine. Soft Matter 19:5179\u20135192","journal-title":"Soft Matter"},{"key":"6_CR83","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0006-3495(89)82807-3","volume":"55","author":"MC Wiener","year":"1989","unstructured":"Wiener MC, Suter RM, Nagle JF (1989) Structure of the fully hydrated gel phase of dipalmitoylphosphatidylcholine. Biophys J 55:315\u2013325","journal-title":"Biophys J"},{"key":"6_CR84","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1021\/bi00504a031","volume":"20","author":"DA Wilkinson","year":"1981","unstructured":"Wilkinson DA, Nagle JF (1981) Dilatometry and calorimetry of saturated phosphatidylethanolamine dispersions. Biochemistry 20:187\u2013192","journal-title":"Biochemistry"},{"key":"6_CR85","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.cplett.2006.05.060","volume":"425","author":"GWH Wurpel","year":"2006","unstructured":"Wurpel GWH, M\u00fcller M (2006) Water confined by lipid bilayers: a multiplex CARS study. Chem Phys Lett 425:336\u2013341","journal-title":"Chem Phys Lett"},{"key":"6_CR86","doi-asserted-by":"publisher","first-page":"8322","DOI":"10.1021\/acs.jpcb.7b01276","volume":"121","author":"T Yamada","year":"2017","unstructured":"Yamada T, Takahashi N, Tominaga T, Takata SI, Seto H (2017) Dynamical behavior of hydration water molecules between phospholipid membranes. J Phys Chem B 121:8322\u20138329","journal-title":"J Phys Chem B"},{"key":"6_CR87","doi-asserted-by":"publisher","first-page":"062101","DOI":"10.1088\/0953-8984\/22\/6\/062101","volume":"22","author":"YZ Yoon","year":"2010","unstructured":"Yoon YZ, Hale JP, Petrov PG, Cicuta P (2010) Mechanical properties of ternary lipid membranes near a liquid-liquid phase separation boundary. J Phys Condens Matter 22:062101","journal-title":"J Phys Condens Matter"},{"key":"6_CR88","doi-asserted-by":"publisher","first-page":"7881","DOI":"10.1021\/jacs.2c02145","volume":"144","author":"R Zhang","year":"2022","unstructured":"Zhang R, Cross TA, Peng X, Fu R (2022) Surprising rigidity of functionally important water molecules buried in the lipid Headgroup region. J Am Chem Soc 144:7881\u20137888","journal-title":"J Am Chem Soc"},{"key":"6_CR89","doi-asserted-by":"publisher","first-page":"5047","DOI":"10.1103\/PhysRevE.50.5047","volume":"50","author":"R Zhang","year":"1994","unstructured":"Zhang R, Suter RM, Nagle JF (1994a) Theory of the structure factor of lipid bilayers. Phys Rev E 50:5047\u20135060","journal-title":"Phys Rev E"},{"key":"6_CR90","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm1784","volume":"7","author":"J Zimmerberg","year":"2006","unstructured":"Zimmerberg J, Kozlov MM (2006) How proteins produce cellular membrane curvature. Nature Rev 7:9\u201319","journal-title":"Nature Rev"},{"key":"6_CR91","doi-asserted-by":"publisher","first-page":"21376","DOI":"10.1021\/acsnano.4c05857","volume":"18","author":"E Zunzunegui-Bru","year":"2024","unstructured":"Zunzunegui-Bru E, Alfarano SR, Zueblin P, Vondracek H, Piccirilli F, Vaccari L, Assenza S, Mezzenga R (2024) Universality in the structure and dynamics of water under Lipidic Mesophase soft Nanoconfinement. ACS Nano 18:21376\u201321387","journal-title":"ACS Nano"}],"container-title":["Subcellular Biochemistry","Membrane Hydration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-24159-7_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:57:34Z","timestamp":1789646254000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-24159-7_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032241580","9783032241597"],"references-count":91,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-24159-7_6","relation":{},"ISSN":["0306-0225","2542-8810"],"issn-type":[{"value":"0306-0225","type":"print"},{"value":"2542-8810","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2 July 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}