{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:01:33Z","timestamp":1780041693170,"version":"3.53.1"},"publisher-location":"Cham","reference-count":150,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032242532","type":"print"},{"value":"9783032242549","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":149,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-24254-9_5","type":"book-chapter","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:44:29Z","timestamp":1780033469000},"page":"55-69","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is the Association of Granzyme B and the Exported Parasite Hsp70 a Possible Trojan Horse of Severe Malaria?"],"prefix":"10.1007","author":[{"given":"Tendamudzimu Harmfree","family":"Dongola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addmore","family":"Shonhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"5_CR1","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1074\/jbc.M410915200","volume":"280","author":"C Adrain","year":"2005","unstructured":"Adrain C, Murphy BM, Martin SJ (2005) Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte\/natural killer (CTL\/NK) protease granzyme B. J Biol Chem 280:4663\u20134673","journal-title":"J Biol Chem"},{"key":"5_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030587","volume":"9","author":"Z Albakova","year":"2020","unstructured":"Albakova Z, Armeev GA, Kanevskiy LM et al (2020) Hsp70 multi-functionality in cancer. Cells 9:587","journal-title":"Cells"},{"key":"5_CR3","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/joim.12223","volume":"275","author":"C Arama","year":"2014","unstructured":"Arama C, Troye-Blomberg M (2014) The path of malaria vaccine development: challenges and perspectives. Int J Med 275:456\u2013466","journal-title":"Int J Med"},{"key":"5_CR4","doi-asserted-by":"publisher","first-page":"3902","DOI":"10.1074\/jbc.M110513200","volume":"277","author":"G Banumathy","year":"2002","unstructured":"Banumathy G, Singh V, Tatu U (2002) Host chaperones are recruited in membrane-bound complexes by Plasmodium falciparum. J Biol Chem 277:3902\u20133912","journal-title":"J Biol Chem"},{"key":"5_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16044","volume":"8","author":"S Batinovic","year":"2017","unstructured":"Batinovic S, McHugh E, Chisholm S et al (2017) An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes. Nat Commun 8:16044","journal-title":"Nat Commun"},{"key":"5_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-39217-y","volume":"9","author":"A Behl","year":"2019","unstructured":"Behl A, Kumar V, Bisht A et al (2019) Cholesterol bound Plasmodium falciparum co-chaperone \u2018PFA0660w\u2019complexes with major virulence factor \u2018PfEMP1\u2019via chaperone \u2018PfHsp70-x\u2019. Sci Rep 9:1\u20137","journal-title":"Sci Rep"},{"key":"5_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109918","volume":"27","author":"M Behl","year":"2024","unstructured":"Behl M, Maurya A, Saini P et al (2024) Targeting PfProhibitin 2-Hu-Hsp70A1A complex as a unique approach towards malaria vaccine development. iScience 27:109918","journal-title":"iScience"},{"key":"5_CR8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1600-0854.2008.00864.x","volume":"10","author":"JA Boddey","year":"2009","unstructured":"Boddey JA, Moritz RL, Simpson RJ et al (2009) Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic 10:285\u2013299","journal-title":"Traffic"},{"key":"5_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s12192-010-0250-6","volume":"16","author":"M Botha","year":"2011","unstructured":"Botha M, Chiang AN, Needham PG et al (2011) Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock. Cell Stress Chaperones 16:389\u2013401","journal-title":"Cell Stress Chaperones"},{"key":"5_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033774","volume":"7","author":"E B\u00f6ttger","year":"2012","unstructured":"B\u00f6ttger E, Multhoff G, Kun JF et al (2012) Plasmodium falciparum-infected erythrocytes induce granzyme B by NK cells through expression of host-Hsp70. PLoS One 7:e33774","journal-title":"PLoS One"},{"key":"5_CR11","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1006\/jmbi.1996.0465","volume":"261","author":"A Buchberger","year":"1996","unstructured":"Buchberger A, Schr\u00f6der H, Hesterkamp T et al (1996) Substrate shuttling between the DnaK and GroEL systems indicates a chaperone network promoting protein folding. J Mol Biol 261:328\u2013333","journal-title":"J Mol Biol"},{"key":"5_CR12","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.1128\/jb.171.11.6030-6038.1989","volume":"171","author":"B Bukau","year":"1989","unstructured":"Bukau B, Walker GC (1989) Delta dnaK mutants of Escherichia coli have defects in chromosome segregation and plasmid maintenance at normal growth temperatures. J Bacteriol 171:6030\u20136038","journal-title":"J Bacteriol"},{"key":"5_CR13","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cell.2006.04.014","volume":"125","author":"B Bukau","year":"2006","unstructured":"Bukau B, Weissman J, Horwich AL (2006) Molecular chaperones and protein quality control. Cell 125:443\u2013451","journal-title":"Cell"},{"key":"5_CR15","doi-asserted-by":"publisher","first-page":"7871","DOI":"10.1074\/jbc.M111.328591","volume":"287","author":"HE Bullen","year":"2012","unstructured":"Bullen HE, Charnaud SC, Kalanon M et al (2012) Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX). J Biol Chem 287:7871\u20137884","journal-title":"J Biol Chem"},{"key":"5_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005031","volume":"10","author":"JG Burel","year":"2016","unstructured":"Burel JG, Apte SH, McCarthy JS et al (2016) Plasmodium vivax but not Plasmodium falciparum blood-stage infection in humans is associated with the expansion of a CD8+ T cell population with cytotoxic potential. PLoS Negl Trop Dis 10:e0005031","journal-title":"PLoS Negl Trop Dis"},{"key":"5_CR17","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1074\/jbc.M606564200","volume":"282","author":"L Casciola-Rosen","year":"2007","unstructured":"Casciola-Rosen L, Garcia-Calvo M, Bull HG et al (2007) Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway. J Biol Chem 282:4545\u20134552","journal-title":"J Biol Chem"},{"key":"5_CR18","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s10571-009-9348-8","volume":"29","author":"GV Chaitanya","year":"2009","unstructured":"Chaitanya GV, Babu PP (2009) Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat. Cell Mol Neurobiol 29:563\u2013573","journal-title":"Cell Mol Neurobiol"},{"key":"5_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12551-019-00563-w","volume":"11","author":"G Chakafana","year":"2019","unstructured":"Chakafana G, Zininga T, Shonhai A (2019a) Comparative structure-function features of Hsp70s of Plasmodium falciparum and human origins. Biophys Rev 11:1\u201312","journal-title":"Biophys Rev"},{"key":"5_CR20","doi-asserted-by":"publisher","first-page":"543","DOI":"10.3390\/biom9100543","volume":"9","author":"G Chakafana","year":"2019","unstructured":"Chakafana G, Zininga T, Shonhai A (2019b) The link that binds: the linker of Hsp70 as a helm of the protein\u2019s function. Biomolecules 9:543","journal-title":"Biomolecules"},{"key":"5_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29690","volume":"10","author":"G Chakafana","year":"2024","unstructured":"Chakafana G, Middlemiss CJ, Zininga T et al (2024) Swapping the linkers of canonical Hsp70 and Hsp110 chaperones compromises both self-association and client selection. Heliyon 10:e29690","journal-title":"Heliyon"},{"key":"5_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204785","volume":"13","author":"SC Charnaud","year":"2017","unstructured":"Charnaud SC, Kumarasingha R, Bullen H et al (2017) Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export. PLoS One 13:e0204785","journal-title":"PLoS One"},{"key":"5_CR23","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.bmc.2009.01.024","volume":"17","author":"AN Chiang","year":"2009","unstructured":"Chiang AN, Valderramos JC, Balachandran R et al (2009) Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorgan Med Chem 17:1527\u20131533","journal-title":"Bioorgan Med Chem"},{"key":"5_CR24","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1086\/340213","volume":"185","author":"K Chotivanich","year":"2002","unstructured":"Chotivanich K, Udomsangpetch R, McGready R (2002) Central role of the spleen in malaria parasite clearance. J Infect Dis 185:1538\u20131541","journal-title":"J Infect Dis"},{"key":"5_CR25","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1146\/annurev.immunol.26.021607.090404","volume":"26","author":"D Chowdhury","year":"2008","unstructured":"Chowdhury D, Lieberman J (2008) Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol 26:389\u2013420","journal-title":"Annu Rev Immunol"},{"key":"5_CR26","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00363-17","volume":"2","author":"DW Cobb","year":"2017","unstructured":"Cobb DW, Florentin A, Fierro MA et al (2017) The exported chaperone PfHsp70x is dispensable for the Plasmodium falciparum intraerythrocytic life cycle. mSphere 2:e00363\u201317","journal-title":"mSphere"},{"key":"5_CR27","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41577-023-00837-1","volume":"23","author":"M Colonna","year":"2023","unstructured":"Colonna M (2023) The biology of TREM receptors. Nat Rev Immunol 23:580\u2013594","journal-title":"Nat Rev Immunol"},{"key":"5_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04037","volume":"6","author":"GT Cort\u00e9s","year":"2020","unstructured":"Cort\u00e9s GT, Wiser MF, G\u00f3mez-Alegr\u00eda CJ (2020) Identification of Plasmodium falciparum HSP70-2 as a resident of the Plasmodium export compartment. Heliyon 6:e04037","journal-title":"Heliyon"},{"key":"5_CR29","doi-asserted-by":"publisher","first-page":"6952","DOI":"10.1182\/blood-2011-08-376111","volume":"118","author":"G Costa","year":"2011","unstructured":"Costa G, Loizon S, Guenot M et al (2011) Control of Plasmodium falciparum erythrocytic cycle: \u03b3\u03b4 T cells target the red blood cell-invasive merozoites. Blood 118:6952\u20136962","journal-title":"Blood"},{"key":"5_CR30","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/sj.cdd.4402244","volume":"15","author":"SP Cullen","year":"2008","unstructured":"Cullen SP, Martin SJ (2008) Mechanisms of granule-dependent killing. Cell Death Differ 15:251\u2013262","journal-title":"Cell Death Differ"},{"key":"5_CR31","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1083\/jcb.200612025","volume":"176","author":"SP Cullen","year":"2007","unstructured":"Cullen SP, Adrain C, Luthi AU et al (2007) Human and murine granzyme B exhibit divergent substrate preferences. J Cell Biol 176:435\u2013444","journal-title":"J Cell Biol"},{"key":"5_CR32","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/cdd.2009.206","volume":"17","author":"SP Cullen","year":"2010","unstructured":"Cullen SP, Brunet M, Martin SJ (2010) Granzymes in cancer and immunity. Cell Death Differ 17:616\u2013623","journal-title":"Cell Death Differ"},{"key":"5_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83093-4","volume":"11","author":"T Damelang","year":"2021","unstructured":"Damelang T, Aitken EH et al (2021) Antibody mediated activation of natural killer cells in malaria exposed pregnant women. Sci Rep 11:4130","journal-title":"Sci Rep"},{"key":"5_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008261","volume":"16","author":"TK Darling","year":"2011","unstructured":"Darling TK, Mimche PN, Bray C et al (2011) EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog 16:e1008261","journal-title":"PLoS Pathog"},{"key":"5_CR35","doi-asserted-by":"publisher","first-page":"14611","DOI":"10.1096\/fj.201901741R","volume":"33","author":"J Day","year":"2019","unstructured":"Day J, Passecker A, Beck HP et al (2019) The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite. FASEB J 33:14611\u201314624","journal-title":"FASEB J"},{"key":"5_CR36","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/nature08104","volume":"459","author":"TF de Koning-Ward","year":"2009","unstructured":"de Koning-Ward TF, Gilson PR, Boddey JA et al (2009) A newly discovered protein export machine in malaria parasites. Nature 459:945\u2013949","journal-title":"Nature"},{"key":"5_CR37","doi-asserted-by":"publisher","first-page":"21107","DOI":"10.1074\/jbc.M001293200","volume":"275","author":"S Diamant","year":"2000","unstructured":"Diamant S, Peres Ben-Zvi A, Bukau B et al (2000) Size-dependent disaggregation of stable protein aggregates by the DnaK chaperone machinery. J Biol Chem 275:21107\u201321113","journal-title":"J Biol Chem"},{"key":"5_CR38","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/978-1-0716-2189-9_48","volume":"2470","author":"JK Dick","year":"2022","unstructured":"Dick JK, Hart GT (2022) Natural killer cell antibody-dependent cellular cytotoxicity (ADCC) activity against plasmodium falciparum-infected red blood cells. Methods Mol Biol 2470:641\u2013657","journal-title":"Methods Mol Biol"},{"key":"5_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009969","volume":"17","author":"M Diehl","year":"2021","unstructured":"Diehl M, Roling L, Rohland L et al (2021) Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence. PLoS Pathog 17:e1009969","journal-title":"PLoS Pathog"},{"key":"5_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128070","volume":"255","author":"TH Dongola","year":"2024","unstructured":"Dongola TH, Chakafana G, Middlemiss C et al (2024) Insertion of GGMP repeat residues of Plasmodium falciparum Hsp70-1 in the lid of DnaK adversely impacts client recognition. Int J Biol Macromol 255:128070","journal-title":"Int J Biol Macromol"},{"key":"5_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43181-7","volume":"14","author":"NL Dooley","year":"2023","unstructured":"Dooley NL, Chabikwa TG, Pava Z et al (2023) Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets. Nat Commun 14:7387","journal-title":"Nat Commun"},{"key":"5_CR42","doi-asserted-by":"publisher","first-page":"625","DOI":"10.3389\/fmicb.2014.00625","volume":"5","author":"JN Dups","year":"2014","unstructured":"Dups JN, Pepper M, Cockburn IA (2014) Antibody and B cell responses to Plasmodium sporozoites. Front Microbiol 5:625","journal-title":"Front Microbiol"},{"key":"5_CR43","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s12192-020-01181-2","volume":"26","author":"T Dutta","year":"2021","unstructured":"Dutta T, Singh H, Gestwicki JE et al (2021a) Exported plasmodial J domain protein, PFE0055c, and PfHsp70-x form a specific co-chaperone-chaperone partnership. Cell Stress Chaperones 26:355\u2013366","journal-title":"Cell Stress Chaperones"},{"key":"5_CR44","series-title":"Advances in experimental medicine and biology 1340","volume-title":"Heat shock proteins of malaria","author":"T Dutta","year":"2021","unstructured":"Dutta T, Pesce ER, Maier AG et al (2021b) Role of the J domain protein family in the survival and pathogenesis of Plasmodium falciparum. In: Shonhai A, Picard D, Blatch GL (eds) Heat shock proteins of malaria, Advances in experimental medicine and biology 1340. Springer, Cham"},{"key":"5_CR46","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.jmb.2010.09.051","volume":"404","author":"M El Bakkouri","year":"2010","unstructured":"El Bakkouri M, Pow A, Mulichak A et al (2010) The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum. J Mol Biol 404:456\u2013457","journal-title":"J Mol Biol"},{"key":"5_CR47","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.canlet.2019.10.037","volume":"469","author":"MIY Elmallah","year":"2020","unstructured":"Elmallah MIY, Cordonnier M, Vautrot V et al (2020) Membrane-anchored heat-shock protein 70 (Hsp70) in cancer. Cancer Lett 469:134\u2013141","journal-title":"Cancer Lett"},{"key":"5_CR48","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1515\/BC.2000.148","volume":"381","author":"E Estebanez-Perpina","year":"2000","unstructured":"Estebanez-Perpina E, Fuentes-Prior P, Belorgey D et al (2000) Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue. Biol Chem 381:1203\u20131214","journal-title":"Biol Chem"},{"key":"5_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2051-5960-1-79","volume":"1","author":"DE Fakhari","year":"2013","unstructured":"Fakhari DE, Saidi LG, Wahlster L (2013) Molecular chaperones and protein folding as therapeutic targets in Parkinson\u2019s disease and other synucleinopathies. Acta Neuropathol Commun 1:1\u201379. https:\/\/doi.org\/10.1186\/2051-5960-1-79","journal-title":"Acta Neuropathol Commun"},{"key":"5_CR50","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1002\/eji.200424861","volume":"34","author":"SE Farouk","year":"2004","unstructured":"Farouk SE, Mincheva-Nilsson L, Krensky A et al (2004) Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway that requires granulysin. Eur J Immunol 34:2248\u20132256","journal-title":"Eur J Immunol"},{"key":"5_CR51","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/346623a0","volume":"346","author":"KM Flaherty","year":"1990","unstructured":"Flaherty KM, DeLuca-Flaherty C, McKay DB et al (1990) Three-dimensional structure of the ATPase fragment of a 70 K heat-shock cognate protein. Nature 346:623\u2013628","journal-title":"Nature"},{"key":"5_CR52","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s44321-023-00010-0","volume":"16","author":"J Fraering","year":"2024","unstructured":"Fraering J, Salnot V, Gautier EF et al (2024) Infected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria. EMBO Mol Med 16:319\u2013333","journal-title":"EMBO Mol Med"},{"key":"5_CR53","first-page":"129","volume":"64","author":"JA Garcia-Sanz","year":"1988","unstructured":"Garcia-Sanz JA, Velotti F, MacDonald HR et al (1988) Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli. Immunology 64:129\u2013134","journal-title":"Immunology"},{"key":"5_CR54","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.4049\/jimmunol.145.9.3111","volume":"145","author":"JA Garcia-Sanz","year":"1990","unstructured":"Garcia-Sanz JA, MacDonald HR, Jenne DE, Nabholz M et al (1990) Cell specificity of granzyme gene expression. J Immunol 145:3111\u20133118","journal-title":"J Immunol"},{"key":"5_CR55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001925","volume":"3","author":"M Gehrmann","year":"2008","unstructured":"Gehrmann M, Liebisch G, Schmitz G et al (2008) Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. PLoS One 3:e1925","journal-title":"PLoS One"},{"key":"5_CR56","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s12192-011-0299-x","volume":"17","author":"GW Gitau","year":"2012","unstructured":"Gitau GW, Mandal P, Blatch GL et al (2012) Characterization of the Plasmodium falciparum Hsp70-Hsp90 organizing protein (PfHop). Cell Stress Chaperones 17:191\u2013202","journal-title":"Cell Stress Chaperones"},{"key":"5_CR57","doi-asserted-by":"publisher","first-page":"41173","DOI":"10.1074\/jbc.M302644200","volume":"278","author":"C Gross","year":"2003","unstructured":"Gross C, Koelch W, DeMaio A et al (2003) Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J Biol Chem 278:41173\u201341181","journal-title":"J Biol Chem"},{"key":"5_CR58","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1051\/parasite\/2012002","volume":"20","author":"M Grover","year":"2013","unstructured":"Grover M, Chaubey S, Ranade S et al (2013) Identification of an exported heat shock protein 70 in Plasmodium falciparum. Parasite 20:1123\u20131132","journal-title":"Parasite"},{"key":"5_CR59","doi-asserted-by":"publisher","first-page":"6148","DOI":"10.4049\/jimmunol.1003955","volume":"186","author":"A Haque","year":"2011","unstructured":"Haque A, Best SE, Unosson K et al (2011) Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria. J Immunol 186:6148\u20136156","journal-title":"J Immunol"},{"key":"5_CR60","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1046\/j.1365-2249.2003.02160.x","volume":"132","author":"CC Hermsen","year":"2003","unstructured":"Hermsen CC, Konijnenberg Y, Mulder L et al (2003) Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections. Clin Exp Immunol 132:467\u2013472","journal-title":"Clin Exp Immunol"},{"key":"5_CR61","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.4049\/jimmunol.1900725","volume":"204","author":"MA Hern\u00e1ndez-Casta\u00f1eda","year":"2020","unstructured":"Hern\u00e1ndez-Casta\u00f1eda MA, Happ K, Cattalani F et al (2020) \u03b3\u03b4 T cells kill plasmodium falciparum in a Granzyme- and Granulysin-dependent mechanism during the late blood stage. J Immunol 204:1798\u20131809","journal-title":"J Immunol"},{"key":"5_CR62","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/0092-8674(94)90376-X","volume":"76","author":"JW Heusel","year":"1994","unstructured":"Heusel JW, Wesselschmidt RL, Shresta S et al (1994) Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76:977\u2013987","journal-title":"Cell"},{"key":"5_CR63","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1126\/science.1102737","volume":"306","author":"NL Hiller","year":"2004","unstructured":"Hiller NL, Bhattacharjee S, van Ooij C et al (2004) host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science 306:1934\u20131937","journal-title":"Science"},{"key":"5_CR65","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1128\/iai.62.3.855-862.1994","volume":"62","author":"M Ho","year":"1994","unstructured":"Ho M, Tongtawe P, Kriangkum J et al (1994) Polyclonal expansion of peripheral gamma delta T cells in human Plasmodium falciparum malaria. Infect Immun 62:855\u2013862","journal-title":"Infect Immun"},{"key":"5_CR66","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41586-018-0469-4","volume":"561","author":"CM Ho","year":"2018","unstructured":"Ho CM, Beck JR, Lai M et al (2018) Malaria parasite translocon structure and mechanism of effector export. Nature 561:70\u201375","journal-title":"Nature"},{"key":"5_CR67","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00985-16","volume":"85","author":"MA Huggins","year":"2017","unstructured":"Huggins MA, Johnson HL, Jin F et al (2017) Perforin expression by CD8 T cells is sufficient to cause fatal brain edema during experimental cerebral malaria. Infect Immun 85:e00985-16","journal-title":"Infect Immun"},{"key":"5_CR68","doi-asserted-by":"publisher","first-page":"6124","DOI":"10.1093\/emboj\/17.21.6124","volume":"17","author":"M J\u00e4\u00e4ttel\u00e4","year":"1998","unstructured":"J\u00e4\u00e4ttel\u00e4 M, Wissing D, Kokholm K et al (1998) Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 17:6124\u20136134","journal-title":"EMBO J"},{"key":"5_CR69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000053","volume":"4","author":"D Jani","year":"2008","unstructured":"Jani D, Nagarkatti R, Beatty W et al (2008) HDP-a novel heme detoxification protein from the malaria parasite. PLoS Pathog 4:e1000053","journal-title":"PLoS Pathog"},{"key":"5_CR70","doi-asserted-by":"publisher","first-page":"30781","DOI":"10.1074\/jbc.271.48.30781","volume":"271","author":"DA Jans","year":"1996","unstructured":"Jans DA, Jans P, Briggs LJ et al (1996) Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro. J Biol Chem 271:30781\u201330789","journal-title":"J Biol Chem"},{"key":"5_CR71","doi-asserted-by":"publisher","first-page":"781","DOI":"10.4049\/jimmunol.1100789","volume":"187","author":"W Jiang","year":"2011","unstructured":"Jiang W, Chai NR, Maric D et al (2011) Unexpected role for Granzyme K in CD56bright NK cell-mediated Immunoregulation of multiple sclerosis. J Immunol 187:781\u2013790","journal-title":"J Immunol"},{"key":"5_CR72","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.pt.2021.04.009","volume":"37","author":"TK Jonsdottir","year":"2021","unstructured":"Jonsdottir TK, Gabriela M, Crabb BS (2021) Defining the essential exportome of the malaria parasite. Trends Parasitol 37:664\u2013675","journal-title":"Trends Parasitol"},{"key":"5_CR73","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1128\/IAI.05188-11","volume":"80","author":"MY Kafuye-Mlwilo","year":"2012","unstructured":"Kafuye-Mlwilo MY, Mukherjee P, Chauhan VS (2012) Kinetics of humoral and memory B cell response induced by the Plasmodium falciparum 19-kilodalton merozoite surface protein 1 in mice. Infect Immun 80:633\u2013642","journal-title":"Infect Immun"},{"key":"5_CR74","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02917","volume":"10","author":"LC Kaminski","year":"2019","unstructured":"Kaminski LC, Riehn M, Abel A et al (2019) Cytotoxic T cell-derived granzyme B is increased in severe Plasmodium falciparum Malaria. Front Immunol 10:2917. https:\/\/doi.org\/10.3389\/fimmu.2019.02917","journal-title":"Front Immunol"},{"key":"5_CR75","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1128\/AAC.04190-14","volume":"59","author":"S Kapelski","year":"2015","unstructured":"Kapelski S, de Almeida M, Fischer R et al (2015) Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein. Antimicrob Agents Chemother 59:669\u2013672","journal-title":"Antimicrob Agents Chemother"},{"key":"5_CR76","doi-asserted-by":"publisher","first-page":"570","DOI":"10.2119\/molmed.2016.00130","volume":"22","author":"P Kempaiah","year":"2016","unstructured":"Kempaiah P, Dokladny K, Karim Z et al (2016) Reduced Hsp70 and glutamine in pediatric severe malaria anemia: role of hemozoin in suppressing Hsp70 and NF-\u03baB activation. Mol Med 22:570\u2013584","journal-title":"Mol Med"},{"key":"5_CR77","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev-biochem-060208-092442","volume":"82","author":"YE Kim","year":"2013","unstructured":"Kim YE, Hipp MS, Bracher A et al (2013) Molecular chaperone functions in protein folding and proteostasis. Annu Rev Biochem 82:323\u2013355","journal-title":"Annu Rev Biochem"},{"key":"5_CR78","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13042","volume":"21","author":"HM Kudyba","year":"2019","unstructured":"Kudyba HM, Cobb DW, Fierro MA et al (2019) The endoplasmic reticulum chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites. Cell Microbiol 21:e13042","journal-title":"Cell Microbiol"},{"key":"5_CR79","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1111\/j.1462-5822.2010.01477.x","volume":"12","author":"S K\u00fclzer","year":"2010","unstructured":"K\u00fclzer S, Rug M, Brinkmann K et al (2010) Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte. Cell Microbiol 12:1398\u20131420","journal-title":"Cell Microbiol"},{"key":"5_CR80","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1111\/j.1462-5822.2012.01840.x","volume":"14","author":"S K\u00fclzer","year":"2012","unstructured":"K\u00fclzer S, Charnaud S, Dagan T et al (2012) Plasmodium falciparum-encoded exported Hsp70\/Hsp40 chaperone\/co-chaperone complexes within the host erythrocyte. Cell Microbiol 14:1784\u20131795","journal-title":"Cell Microbiol"},{"key":"5_CR81","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0166-6851(91)90163-Z","volume":"48","author":"N Kumar","year":"1991","unstructured":"Kumar N, Koski G, Harada M et al (1991) Induction and localization of Plasmodium falciparum stress proteins related to the heat shock protein 70 family. Mol Biochem Parasitol 48:47\u201358","journal-title":"Mol Biochem Parasitol"},{"key":"5_CR82","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1089\/ars.2006.8.1183","volume":"8","author":"F Lang","year":"2006","unstructured":"Lang F, Lang KS, Lang PA et al (2006) Mechanisms and significance of eryptosis. Antioxid Redox Signal 8:1183\u20131192","journal-title":"Antioxid Redox Signal"},{"key":"5_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060856","volume":"10","author":"CM Lebepe","year":"2020","unstructured":"Lebepe CM, Matambanadzo PR, Makhoba et al (2020) Comparative characterization of Plasmodium falciparum Hsp70-1 relative to E. coli DnaK reveals the functional specificity of the parasite chaperone. Biomolecules 10:856. https:\/\/doi.org\/10.3390\/biom10060856","journal-title":"Biomolecules"},{"key":"5_CR84","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3389\/fimmu.2019.01444","volume":"10","author":"WC Lee","year":"2019","unstructured":"Lee WC, Russell B, R\u00e9nia L (2019) Sticking for a cause: the Falciparum Malaria parasites cytoadherence paradigm. Front Immunol 10:1444","journal-title":"Front Immunol"},{"key":"5_CR85","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nri1083","volume":"3","author":"J Lieberman","year":"2003","unstructured":"Lieberman J (2003) The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 3:361\u2013370","journal-title":"Nat Rev Immunol"},{"key":"5_CR86","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1128\/IAI.02796-14","volume":"83","author":"P Liehl","year":"2015","unstructured":"Liehl P, Meireles P, Albuquerque IS et al (2015) Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections. Infect Immun 83:1172\u20131180","journal-title":"Infect Immun"},{"key":"5_CR87","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/prot.25600","volume":"86","author":"B Mabate","year":"2018","unstructured":"Mabate B, Zininga T, Ramatsui L et al (2018) Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif. Proteins 86:1189\u20131201","journal-title":"Proteins"},{"key":"5_CR88","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.cell.2008.04.051","volume":"134","author":"AG Maier","year":"2008","unstructured":"Maier AG, Rug M, O\u2019Neill MT (2008) Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell 134:48\u201361","journal-title":"Cell"},{"key":"5_CR89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152626","volume":"11","author":"XH Makhoba","year":"2016","unstructured":"Makhoba XH, Burger A, Coertzen D et al (2016) Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum S-Adenosylmethionine decarboxylase protein produced in Escherichia coli. PLoS One 11:e0152626","journal-title":"PLoS One"},{"key":"5_CR90","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042226","volume":"22","author":"S Makumire","year":"2021","unstructured":"Makumire S, Dongola TH, Chakafana G et al (2021) Mutation of GGMP repeat segments of Plasmodium falciparum Hsp70-1 compromises chaperone function and Hop co-chaperone binding. Int J Mol Sci 22:2226. https:\/\/doi.org\/10.3390\/ijms22042226","journal-title":"Int J Mol Sci"},{"key":"5_CR92","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1083\/jcb.200508051","volume":"171","author":"M Marti","year":"2005","unstructured":"Marti M, Baum J, Rug M et al (2005) Signal-mediated export of proteins from the malaria parasite to the host erythrocyte. J Cell Biol 171:587\u2013592","journal-title":"J Cell Biol"},{"key":"5_CR93","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1002\/j.1460-2075.1996.tb00598.x","volume":"15","author":"SJ Martin","year":"1996","unstructured":"Martin SJ, Amarante-Mendes GP, Shi L et al (1996) The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE\/CED-3 family protease, CPP32, via a novel two-step mechanism. EMBO J 15:2407\u20132416","journal-title":"EMBO J"},{"key":"5_CR94","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1002\/j.1460-2075.1986.tb04401.x","volume":"5","author":"D Masson","year":"1986","unstructured":"Masson D, Nabholz C, Estrade J et al (1986) Granules of cytolytic T-lymphocytes contain two serine esterases. EMBO J 5:1595\u20131600","journal-title":"EMBO J"},{"key":"5_CR95","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","volume":"62","author":"MP Mayer","year":"2005","unstructured":"Mayer MP, Bukau B (2005) Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 62:670\u2013684","journal-title":"Cell Mol Life Sci"},{"key":"5_CR01","doi-asserted-by":"publisher","unstructured":"Menard D, Dondorp A (2017). Antimalarial drug resistance: a threat to malaria elimination. Cold Spring Harb Perspect Med 7(7):a025619. https:\/\/doi.org\/10.1101\/cshperspect.a025619","DOI":"10.1101\/cshperspect.a025619"},{"key":"5_CR96","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1086\/518253","volume":"195","author":"B Meslin","year":"2007","unstructured":"Meslin B, Barnadas C, Boni V et al (2007) Features of apoptosis in Plasmodium falciparum erythrocytic stage through a putative role of PfMCA1 metacaspase-like protein. J Infect Dis 195:1852\u20131859","journal-title":"J Infect Dis"},{"key":"5_CR97","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1080\/0265673021000017109","volume":"18","author":"G Multhoff","year":"2002","unstructured":"Multhoff G (2002) Hyperthermia classic commentary: activation of natural killer (NK) cells by heat shock protein 70, Gabriele Multhoff. Int J Hyperth 18:576\u2013585","journal-title":"Int J Hyperth"},{"key":"5_CR98","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ymeth.2007.06.006","volume":"43","author":"G Multhoff","year":"2007","unstructured":"Multhoff G (2007) Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance. Methods 43:229\u2013237","journal-title":"Methods"},{"key":"5_CR99","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1379\/1466-1268(2001)006<0337:AMHPSN>2.0.CO;2","volume":"6","author":"G Multhoff","year":"2001","unstructured":"Multhoff G, Pfister K, Gehrmann M et al (2001) A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity. Cell Stress Chaperones 6:337\u2013344","journal-title":"Cell Stress Chaperones"},{"key":"5_CR100","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2306","volume":"3","author":"V Muralidharan","year":"2012","unstructured":"Muralidharan V, Oksman A, Pal P et al (2012) Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers. Nat Commun 3:1310. https:\/\/doi.org\/10.1038\/ncomms2306","journal-title":"Nat Commun"},{"key":"5_CR101","doi-asserted-by":"publisher","first-page":"10629","DOI":"10.1073\/pnas.112331099","volume":"99","author":"Y Nagata","year":"2002","unstructured":"Nagata Y, Ono S, Matsuo M et al (2002) Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations. Proc Natl Acad Sci USA 99:10629\u201310634","journal-title":"Proc Natl Acad Sci USA"},{"key":"5_CR102","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-314","volume":"13","author":"A Nasr","year":"2014","unstructured":"Nasr A, Allam G, Hamid O et al (2014) IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women. Malar J 13:314. https:\/\/doi.org\/10.1186\/1475-2875-13-314","journal-title":"Malar J"},{"key":"5_CR103","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.4049\/jimmunol.170.4.2221","volume":"170","author":"J Nitcheu","year":"2003","unstructured":"Nitcheu J, Bonduelle O, Combadiere C et al (2003) Combadiere Perforin-dependent brain-infiltrating cytotoxic CD8 + T lymphocytes mediate experimental cerebral malaria pathogenesis. J Immunol 170:2221\u20132228","journal-title":"J Immunol"},{"key":"5_CR104","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2174\/138161213804143734","volume":"19","author":"JM Njunge","year":"2013","unstructured":"Njunge JM, Ludewig MH, Boshoff A et al (2013) Hsp70s and J proteins of Plasmodium parasites infecting rodents and primates: structure, function, clinical relevance, and drug targets. Curr Pharm Des 19:387\u2013403","journal-title":"Curr Pharm Des"},{"key":"5_CR105","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biocel.2015.02.008","volume":"62","author":"JM Njunge","year":"2015","unstructured":"Njunge JM, Mandal P, Przyborski JM et al (2015) PFB0595w is a Plasmodium falciparum J protein that co-localizes with PfHsp70-1 and can stimulate its in vitro ATP hydrolysis activity. Int J Biochem Cell Biol 62:47\u201353","journal-title":"Int J Biochem Cell Biol"},{"key":"5_CR106","doi-asserted-by":"publisher","first-page":"12038","DOI":"10.1073\/pnas.201112398","volume":"98","author":"EA Nollen","year":"2001","unstructured":"Nollen EA, Salomons FA, Brunsting JF et al (2001) Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Proc Natl Acad Sci USA 98:12038\u201312043","journal-title":"Proc Natl Acad Sci USA"},{"key":"5_CR02","doi-asserted-by":"publisher","unstructured":"Oakley MS, Gerald N, McCutchan TF, Aravind L, Kumar S (2011) Clinical and molecular aspects of malaria fever. Trends Parasitol 27(10):442\u2013449. https:\/\/doi.org\/10.1016\/j.pt.2011.06.004","DOI":"10.1016\/j.pt.2011.06.004"},{"key":"5_CR107","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1083\/jcb.200406115","volume":"167","author":"J Pardo","year":"2004","unstructured":"Pardo J, Bosque A, Brehm RA et al (2004) Apoptotic pathways are selectively activated by granzyme A and\/or granzyme B in CTL-mediated target cell lysis. J Cell Biol 167:457\u2013468","journal-title":"J Cell Biol"},{"key":"5_CR108","doi-asserted-by":"publisher","first-page":"46692","DOI":"10.1074\/jbc.M409165200","volume":"279","author":"SR Pavithra","year":"2004","unstructured":"Pavithra SR, Banumathy G, Joy O, Singh V, Tatu U (2004) Recurrent fever promotes Plasmodium falciparum development in human erythrocytes. J Biol Chem 279:46692\u201346699","journal-title":"J Biol Chem"},{"key":"5_CR109","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/S0021-9258(18)52407-8","volume":"266","author":"M Poe","year":"1991","unstructured":"Poe M, Blake JT, Boulton DA et al (1991) Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. J Biol Chem 266:98\u2013103","journal-title":"J Biol Chem"},{"key":"5_CR110","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","volume":"6","author":"A Porter","year":"1999","unstructured":"Porter A, J\u00e4nicke R (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99\u2013104","journal-title":"Cell Death Differ"},{"key":"5_CR111","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1080\/15548627.2015.1067361","volume":"11","author":"M Prado","year":"2015","unstructured":"Prado M, Eickel N, De Niz M et al (2015) Long-term live imaging reveals cytosolic immune responses of host hepatocytes against Plasmodium infection and parasite escape mechanisms. Autophagy 11:1561\u20131579","journal-title":"Autophagy"},{"key":"5_CR112","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/fmolb.2015.00034","volume":"2","author":"JM Przyborski","year":"2015","unstructured":"Przyborski JM, Diehl M, Blatch GL (2015) Plasmodial HSP70s are functionally adapted to the malaria parasite life cycle. Front Mol Biosci 2:34","journal-title":"Front Mol Biosci"},{"key":"5_CR113","doi-asserted-by":"crossref","unstructured":"Rahimi BA, Thakkinstian A, White NJ et al (2014) Severe vivax malaria: a systematic review and meta-analysis of clinical studies since 1900. Malar J 13:481","DOI":"10.1186\/1475-2875-13-481"},{"key":"5_CR114","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s12192-023-01339-8","volume":"28","author":"L Ramatsui","year":"2023","unstructured":"Ramatsui L, Dongola TH, Zininga T et al (2023) Human granzyme B binds Plasmodium falciparum Hsp70-x and mediates antiplasmodial activity in vitro. Cell Stress Chaperones 28:321\u2013331","journal-title":"Cell Stress Chaperones"},{"key":"5_CR115","doi-asserted-by":"publisher","first-page":"36174","DOI":"10.1038\/srep36174","volume":"6","author":"V Rhiel","year":"2016","unstructured":"Rhiel V, Bittl A, Tribensky SC (2016) Trafficking of the exported P. falciparum chaperone PfHsp70x. Sci Rep 6:36174","journal-title":"Sci Rep"},{"key":"5_CR116","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.chom.2015.10.006","volume":"18","author":"V Risco-Castillo","year":"2015","unstructured":"Risco-Castillo V, Topcu S, Marinach C et al (2015) Malaria sporozoites traverse host cells within transient vacuoles. Cell Host Microbe 18:593\u2013603","journal-title":"Cell Host Microbe"},{"key":"5_CR117","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S1074-5521(01)00018-7","volume":"8","author":"J Rotonda","year":"2001","unstructured":"Rotonda J, Garcia-Calvo M, Bull HG et al (2001) The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid. Chem Biol 8:357\u2013368","journal-title":"Chem Biol"},{"key":"5_CR118","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/infdis\/162.1.283-a","volume":"162","author":"C Roussilhon","year":"1990","unstructured":"Roussilhon C, Agrapart M, Ballet JJ (1990) T lymphocytes bearing the gamma delta T cell receptor in patients with acute Plasmodium falciparum malaria. J Infect Dis 162:283\u2013285","journal-title":"J Infect Dis"},{"key":"5_CR119","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000606","volume":"18","author":"SW Ryu","year":"2020","unstructured":"Ryu SW, Stewart R, Pectol DC et al (2020) Proteome-wide identification of HSP70\/HSC70 chaperone clients in human cells. PLoS Biol 18:e3000606","journal-title":"PLoS Biol"},{"key":"5_CR120","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nrm3658","volume":"14","author":"H Saibil","year":"2013","unstructured":"Saibil H (2013) Chaperone machines for protein folding, unfolding and disaggregation. Nat Rev Mol Cell Biol 14:630\u2013642","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5_CR121","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.molimm.2015.03.006","volume":"67","author":"CQ Schmidt","year":"2015","unstructured":"Schmidt CQ, Kennedy AT, Tham WH (2015) More than just immune evasion: hijacking complement by Plasmodium falciparum. Mol Immunol 67:71\u201384","journal-title":"Mol Immunol"},{"key":"5_CR122","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136889","volume":"22","author":"TN Sharapova","year":"2021","unstructured":"Sharapova TN, Romanova EA, Ivanova OK et al (2021) Hsp70 interacts with the TREM-1 receptor expressed on monocytes and thereby stimulates generation of cytotoxic lymphocytes active against MHC-negative tumor cells. Int J Mol Sci 22:6889","journal-title":"Int J Mol Sci"},{"key":"5_CR123","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900205","volume":"15","author":"M Shevtsov","year":"2019","unstructured":"Shevtsov M, Stangl S, Nikolaev B et al (2019) Granzyme B functionalized nanoparticles targeting membrane Hsp70-positive tumors for multimodal cancer theranostics. Small 15:e1900205","journal-title":"Small"},{"key":"5_CR125","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s00438-005-1150-9","volume":"274","author":"A Shonhai","year":"2005","unstructured":"Shonhai A, Boshoff A, Blatch GL (2005) Molecular characterization of the chaperone properties of plasmodium falciparum heat shock protein 70. Mol Gen Genet 274:70\u201378","journal-title":"Mol Gen Genet"},{"key":"5_CR126","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1110\/ps.072918107","volume":"16","author":"A Shonhai","year":"2007","unstructured":"Shonhai A, Boshoff A, Blatch GL (2007) The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum. Protein Sci 16:1803\u20131818","journal-title":"Protein Sci"},{"key":"5_CR03","doi-asserted-by":"publisher","unstructured":"Shonhai A (2021) The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum. Adv Exp Med Biol 1340:75\u201395. https:\/\/doi.org\/10.1007\/978-3-030-78397-6_3","DOI":"10.1007\/978-3-030-78397-6_3"},{"key":"5_CR128","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21083","volume":"6","author":"X Sisquella","year":"2017","unstructured":"Sisquella X, Nebl T, Thompson JK et al (2017) Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion. elife 6:e21083","journal-title":"elife"},{"key":"5_CR130","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98911","volume":"3","author":"EW Sorensen","year":"2018","unstructured":"Sorensen EW, Lian J, Ozga AJ et al (2018) CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria. JCI Insight 3:e98911","journal-title":"JCI Insight"},{"key":"5_CR131","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nri749","volume":"2","author":"P Srivastava","year":"2002","unstructured":"Srivastava P (2002) Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2:185\u2013194","journal-title":"Nat Rev Immunol"},{"key":"5_CR132","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0166-6851(92)90108-V","volume":"54","author":"IK Srivastava","year":"1992","unstructured":"Srivastava IK, Schmidt M, Grall M, Certa U, Garcia AM, Perrin LH (1992) Identification and purification of glucose phosphate isomerase of Plasmodium falciparum. Mol Biochem Parasitol 54:153\u2013164","journal-title":"Mol Biochem Parasitol"},{"key":"5_CR133","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.pep.2011.01.005","volume":"77","author":"LL Stephens","year":"2011","unstructured":"Stephens LL, Shonhai A, Blatch GL (2011) Co-expression of the Plasmodium falciparum molecular chaperone, PfHsp70, improves the heterologous production of the antimalarial drug target GTP cyclohydrolase I, PfGCHI. Protein Expr Purif 77:159\u2013165","journal-title":"Protein Expr Purif"},{"key":"5_CR134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006022","volume":"12","author":"PA Swanson","year":"2016","unstructured":"Swanson PA, Hart GT, Russo MV (2016) CD8+ T cells induce fatal brainstem pathology during cerebral malaria via luminal antigen-specific engagement of brain vasculature. PLoS Pathog 12:e1006022","journal-title":"PLoS Pathog"},{"key":"5_CR135","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/cc2183","volume":"27","author":"A Trampuz","year":"2003","unstructured":"Trampuz A, Jereb M, Muzlovic I et al (2003) Clinical review: severe malaria. Crit Care 27:315\u2013323","journal-title":"Crit Care"},{"key":"5_CR136","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0952-7915(03)00107-9","volume":"15","author":"JA Trapani","year":"2003","unstructured":"Trapani JA, Sutton VR (2003) Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr Opin Immunol 15:533\u2013543","journal-title":"Curr Opin Immunol"},{"key":"5_CR137","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1182\/blood-2006-03-010348","volume":"108","author":"CM Tschopp","year":"2006","unstructured":"Tschopp CM, Spiegl N, Didichenko S et al (2006) Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood 108:2290\u20132299","journal-title":"Blood"},{"key":"5_CR138","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1002\/jcp.30132","volume":"236","author":"MA Vostakolaei","year":"2021","unstructured":"Vostakolaei MA, Hatami-Baroogh L, Babaei G et al (2021) Hsp70 in cancer: a double agent in the battle between survival and death. J Cell Physiol 236:3420\u20133444","journal-title":"J Cell Physiol"},{"key":"5_CR139","doi-asserted-by":"publisher","first-page":"26049","DOI":"10.1016\/S0021-9258(19)74274-4","volume":"268","author":"TF Wang","year":"1993","unstructured":"Wang TF, Chang J, Wang C (1993) Identification of the peptide binding domain of hsc70. 18-Kilodalton fragment located immediately after ATPase domain is sufficient for high affinity binding. J Biol Chem 268:26049\u201326051","journal-title":"J Biol Chem"},{"key":"5_CR140","doi-asserted-by":"publisher","first-page":"4476","DOI":"10.1074\/jbc.M410985200","volume":"280","author":"NJ Waterhouse","year":"2005","unstructured":"Waterhouse NJ, Sedelies KA, Browne KA et al (2005) A central role for Bid in granzyme B-induced apoptosis. J Biol Chem 280:4476\u20134482","journal-title":"J Biol Chem"},{"key":"5_CR141","unstructured":"WHO (2021) https:\/\/www.who.int\/publications\/i\/item\/9789240015791. Accessed Nov 2022"},{"key":"5_CR142","unstructured":"WHO (2022) https:\/\/www.who.int\/news\/item\/08-12-2022. Accessed January 2024"},{"key":"5_CR143","unstructured":"WHO (2024) World Health Organization world malaria report. https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2024"},{"key":"5_CR144","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.3201\/eid.1707.101017","volume":"17","author":"T William","year":"2011","unstructured":"William T, Menon J, Rajahram G et al (2011) Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia. Emerg Infect Dis 17:1248\u20131255","journal-title":"Emerg Infect Dis"},{"issue":"suppl 1","key":"5_CR145","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/S0035-9203(00)90300-6","volume":"94","author":"World Health Organization","year":"2000","unstructured":"World Health Organization (2000) Severe falciparum malaria. Trans R Soc Trop Med Hyg 94(suppl 1):S1\u2013S90","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"5_CR147","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1093\/jb\/mvr083","volume":"150","author":"T Yano","year":"2011","unstructured":"Yano T, Kurata S (2011) Intracellular recognition of pathogens and autophagy as an innate immune host defence. J Biochem 150:143\u2013149","journal-title":"J Biochem"},{"key":"5_CR04","doi-asserted-by":"publisher","unstructured":"Yazdi M, Hasanzadeh Kafshgari M, Khademi Moghadam F et al (2024) Crosstalk between NK cell receptors and tumor membrane Hsp70-Derived peptide: a combined computational and experimental study. Adv Sci (Weinh) 11(14):e2305998. https:\/\/doi.org\/10.1002\/advs.202305998","DOI":"10.1002\/advs.202305998"},{"key":"5_CR148","doi-asserted-by":"publisher","first-page":"5746","DOI":"10.1073\/pnas.101329598","volume":"98","author":"D Zhang","year":"2001","unstructured":"Zhang D, Beresford PJ, Greenberg AH et al (2001a) Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci USA 98:5746\u20135751","journal-title":"Proc Natl Acad Sci USA"},{"key":"5_CR149","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S1286-4579(01)01391-0","volume":"3","author":"M Zhang","year":"2001","unstructured":"Zhang M, Hisaeda H, Kano S (2001b) Antibodies specific for heat shock proteins in human and murine malaria. Microbes Infect 3:363\u2013367","journal-title":"Microbes Infect"},{"key":"5_CR150","doi-asserted-by":"publisher","DOI":"10.1038\/srep42188","volume":"7","author":"Q Zhang","year":"2017","unstructured":"Zhang Q, Ma C, Oberli A et al (2017) Proteomic analysis of exported chaperone\/co-chaperone complexes of P. falciparum reveals an array of complex protein\u2013protein interactions. Sci Rep 7:42188","journal-title":"Sci Rep"},{"key":"5_CR151","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/362605","volume":"2014","author":"H Zheng","year":"2014","unstructured":"Zheng H, Tan Z, Xu W (2014) Immune evasion strategies of pre-erythrocytic malaria parasites. Mediat Inflamm 2014:362605","journal-title":"Mediat Inflamm"},{"key":"5_CR152","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s12192-016-0678-4","volume":"21","author":"T Zininga","year":"2016","unstructured":"Zininga T, Achilonu I, Hoppe H et al (2016) Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion. Cell Stress Chaperones 21:499\u2013513","journal-title":"Cell Stress Chaperones"},{"key":"5_CR153","series-title":"Advances in experimental medicine and biology 1340","volume-title":"Heat shock proteins of malaria","author":"T Zininga","year":"2021","unstructured":"Zininga T, B\u00f6ttger E, Multhoff G (2021) Role of heat shock proteins in immune modulation in malaria. In: Shonhai A, Picard D, Blatch GL (eds) Heat shock proteins of malaria, Advances in experimental medicine and biology 1340. Springer, Cham"},{"key":"5_CR05","doi-asserted-by":"publisher","unstructured":"Zorzi E, Bonvini P (2011) Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity. Cancers (Basel) 3(4):3921\u20133656. https:\/\/doi.org\/10.3390\/cancers3043921","DOI":"10.3390\/cancers3043921"}],"container-title":["Advances in Experimental Medicine and Biology","Advances in Biochemistry and Molecular Biology to meet Africa\u00b4s Needs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-24254-9_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:03:05Z","timestamp":1780038185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-24254-9_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032242532","9783032242549"],"references-count":150,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-24254-9_5","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"30 May 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"SASBMB","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"South African Society for Biochemistry and Molecular Biology Congress","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Polokwane","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"South Africa","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2024","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"7 July 2024","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"10 July 2024","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"28","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"sasbmb2024","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/www.sasbmbcongress.co.za\/about-the-sasbmb\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}