{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:39:24Z","timestamp":1792604364858,"version":"4.5.0"},"publisher-location":"Cham","reference-count":58,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032294364","type":"print"},{"value":"9783032294371","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-29437-1_6","type":"book-chapter","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:55:37Z","timestamp":1792601737000},"page":"103-116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mass Spectrometry-Based Tissue Imaging of Small Molecules"],"prefix":"10.1007","author":[{"given":"Carly N.","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W. M.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan F.","family":"Waxer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2027,1,23]]},"reference":[{"key":"6_CR1","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/mas.20124","volume":"26","author":"LA Mcdonnell","year":"2007","unstructured":"Mcdonnell LA, Heeren RMA (2007b) Imaging mass spectrometry. Mass Spectrom Rev 26:606\u2013643","journal-title":"Mass Spectrom Rev"},{"key":"6_CR2","volume-title":"Detection of biological agents for the prevention of bioterrorism","author":"M Reyzer","year":"2011","unstructured":"Reyzer M, Caprioli R (2011) Imaging mass spectrometry. In: Banoub J (ed) Detection of biological agents for the prevention of bioterrorism. Springer, Netherlands"},{"key":"6_CR3","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/mas.20124","volume":"26","author":"LA Mcdonnell","year":"2007","unstructured":"Mcdonnell LA, Heeren RM (2007a) Imaging mass spectrometry. Mass Spectrom Rev 26:606\u201343.","journal-title":"Mass Spectrom Rev"},{"key":"6_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4049\/jimmunol.45.3.159","volume":"45","author":"AH Coons","year":"1942","unstructured":"Coons AH, Creech HJ, Jones RN, Berliner E (1942) The demonstration of pneumococcal antigen in tissues by the use of fluorescent antibody. J Immunol 45:159\u201370.","journal-title":"J Immunol"},{"key":"6_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nmeth1145","volume":"5","author":"M Andersson","year":"2008","unstructured":"Andersson M, Groseclose MR, Deutch AY, Caprioli RM (2008) Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction. Nat Meth 5:101\u2013108","journal-title":"Nat Meth"},{"key":"6_CR6","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1373\/clinchem.2005.059592","volume":"52","author":"M Sanchez-Carbayo","year":"2006","unstructured":"Sanchez-Carbayo M (2006) Antibody arrays: technical considerations and clinical applications in cancer. Clin Chem 52:1651\u20131659","journal-title":"Clin Chem"},{"key":"6_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/DAD.0b013e31823df1e2","volume":"34","author":"R Lazova","year":"2012","unstructured":"Lazova R, Seeley EH, Keenan M, Gueorguieva R, Caprioli RM (2012) Imaging mass spectrometry\u2014a new and promising method to differentiate spitz nevi from spitzoid malignant melanomas. Am J Dermatopathol 34:82\u201390","journal-title":"Am J Dermatopathol"},{"key":"6_CR8","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1194\/jlr.E400004-JLR200","volume":"46","author":"E Fahy","year":"2005","unstructured":"Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CRH, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, Van Meer G, Vannieuwenhze MS, White SH, Witztum JL, Dennis EA (2005) A comprehensive classification system for lipids. J Lipid Res 46:839\u2013862.","journal-title":"J Lipid Res"},{"key":"6_CR9","doi-asserted-by":"publisher","first-page":"S317","DOI":"10.1194\/jlr.R800051-JLR200","volume":"50","author":"RC Murphy","year":"2009","unstructured":"Murphy RC, Hankin JA, Barkley RM (2009) Imaging of lipid species by MALDI mass spectrometry. J Lipid Res 50:S317\u2013S322","journal-title":"J Lipid Res"},{"key":"6_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0021-9673(96)00948-X","volume":"765","author":"E Conte","year":"1997","unstructured":"Conte E, Milani R, Morali G, Abballe F (1997) Comparison between accelerated solvent extraction and traditional extraction methods for the analysis of the herbicide diflufenican in soil. J Chromatogr A 765:121\u2013125","journal-title":"J Chromatogr A"},{"key":"6_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/BF02490801","volume":"52","author":"LE Garc\u00eda-Ayuso","year":"2000","unstructured":"Garc\u00eda-Ayuso LE, Velasco J, Dobarganes MC, Luque De Castro MD (2000) Determination of the oil content of seeds by focused microwave-assisted soxhlet extraction. Chromatographia 52:103\u2013108","journal-title":"Chromatographia"},{"key":"6_CR12","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/BF02552721","volume":"70","author":"S Taylor","year":"1993","unstructured":"Taylor S, King J, List G (1993) Determination of oil content in oilseeds by analytical supercritical fluid extraction. J Am Oil Chem Soc 70:437\u2013439","journal-title":"J Am Oil Chem Soc"},{"key":"6_CR13","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1007\/BF02542243","volume":"61","author":"NR Bulley","year":"1984","unstructured":"Bulley NR, Fattori M, Meisen A, Moyls L (1984) Supercritical fluid extraction of vegetable oil seeds. J Am Oil Chem Soc 61:1362\u20131365","journal-title":"J Am Oil Chem Soc"},{"key":"6_CR14","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nrd1776","volume":"4","author":"MR Wenk","year":"2005","unstructured":"Wenk MR (2005) The emerging field of lipidomics. Nat Rev Drug Discov 4:594\u2013610","journal-title":"Nat Rev Drug Discov"},{"key":"6_CR15","doi-asserted-by":"publisher","first-page":"pdb.top83","DOI":"10.1101\/pdb.top83","volume":"2010","author":"C Schultz","year":"2010","unstructured":"Schultz C, Neef AB, Gadella TW, Goedhart J (2010) Imaging Lipids in Living Cells. Cold Spring Harbor Protocols 2010:pdb.top83","journal-title":"Cold Spring Harbor Protocols"},{"key":"6_CR16","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.plipres.2013.04.005","volume":"52","author":"SR Ellis","year":"2013","unstructured":"Ellis SR, Brown SH, IN Het Panhuis M, Blanksby SJ, Mitchell TW (2013) Surface analysis of lipids by mass spectrometry: More than just imaging. Prog Lipid Res 52:329\u2013353","journal-title":"Prog Lipid Res"},{"key":"6_CR17","doi-asserted-by":"publisher","first-page":"6491","DOI":"10.1021\/cr200280p","volume":"111","author":"KA Zemski Berry","year":"2011","unstructured":"Zemski Berry KA, Hankin JA, Barkley RM, Spraggins JM, Caprioli RM, Murphy RC (2011) MALDI imaging of lipid biochemistry in tissues by mass spectrometry. Chem Rev 111:6491\u20136512","journal-title":"Chem Rev"},{"key":"6_CR18","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ijms.2006.09.014","volume":"260","author":"K B\u00f6rner","year":"2007","unstructured":"B\u00f6rner K, Malmberg P, M\u00e5nsson J-E, Nygren H (2007) Molecular imaging of lipids in cells and tissues. Int J Mass Spectrom 260:128\u2013136","journal-title":"Int J Mass Spectrom"},{"key":"6_CR19","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.copbio.2006.06.002","volume":"17","author":"P Chaurand","year":"2006","unstructured":"Chaurand P, Cornett DS, Caprioli RM (2006) Molecular imaging of thin mammalian tissue sections by mass spectrometry. Curr Opin Biotechnol 17:431\u2013436","journal-title":"Curr Opin Biotechnol"},{"key":"6_CR20","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1194\/jlr.D013060","volume":"52","author":"H-YJ Wang","year":"2011","unstructured":"Wang H-YJ, Liu CB, Wu H-W (2011) A simple desalting method for direct MALDI mass spectrometry profiling of tissue lipids. J Lipid Res 52:840\u2013849","journal-title":"J Lipid Res"},{"key":"6_CR21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1021\/cn100096h","volume":"2","author":"B Colsch","year":"2011","unstructured":"Colsch B, Jackson SN, Dutta S, Woods AS (2011) Molecular microscopy of brain gangliosides: illustrating their distribution in hippocampal cell layers. ACS Chem Neurosci 2:213\u2013222","journal-title":"ACS Chem Neurosci"},{"key":"6_CR22","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1021\/cn300216h","volume":"4","author":"AS Woods","year":"2013","unstructured":"Woods AS, Colsch B, Jackson SN, Post J, Baldwin K, Roux A, Hoffer B, Cox BM, Hoffer M, Rubovitch V, Pick CG, Schultz JA, Balaban C (2013) Gangliosides and ceramides change in a mouse model of blast induced traumatic brain injury. ACS Chem Neurosci 4:594\u2013600","journal-title":"ACS Chem Neurosci"},{"key":"6_CR23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/jms.1876","volume":"46","author":"JD Watrous","year":"2011","unstructured":"Watrous JD, Alexandrov T, Dorrestein PC (2011) The evolving field of imaging mass spectrometry and its impact on future biological research. J Mass Spectrom 46:209\u2013222","journal-title":"J Mass Spectrom"},{"key":"6_CR24","doi-asserted-by":"publisher","first-page":"5585","DOI":"10.1021\/ac200619f","volume":"83","author":"L Ferguson","year":"2011","unstructured":"Ferguson L, Bradshaw R, Wolstenholme R, Clench M, Francese S (2011) Two-step matrix application for the enhancement and imaging of latent fingermarks. Anal Chem 83:5585\u20135591","journal-title":"Anal Chem"},{"key":"6_CR25","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.molonc.2010.09.002","volume":"4","author":"K Schwamborn","year":"2010","unstructured":"Schwamborn K, Caprioli RM (2010) MALDI imaging mass spectrometry \u2013 painting molecular pictures. Mol Oncol 4:529\u2013538","journal-title":"Mol Oncol"},{"key":"6_CR26","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/cbic.201100411","volume":"12","author":"LS Eberlin","year":"2011","unstructured":"Eberlin LS, Ferreira CR, Dill AL, Ifa DR, Cheng L, Cooks RG (2011a) Nondestructive, histologically compatible tissue imaging by desorption electrospray ionization mass spectrometry. ChemBioChem 12:2129\u20132132","journal-title":"ChemBioChem"},{"key":"6_CR27","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.plipres.2010.07.001","volume":"49","author":"B Fuchs","year":"2010","unstructured":"Fuchs B, S\u00fcs R, Schiller J (2010) An update of MALDI-TOF mass spectrometry in lipid research. Prog Lipid Res 49:450\u2013475","journal-title":"Prog Lipid Res"},{"key":"6_CR28","doi-asserted-by":"publisher","first-page":"4990","DOI":"10.1021\/ac049581r","volume":"76","author":"G Mccombie","year":"2004","unstructured":"Mccombie G, Knochenmuss R (2004) Small-molecule MALDI using the matrix suppression effect to reduce or eliminate matrix background interferences. Anal Chem 76:4990\u20134997","journal-title":"Anal Chem"},{"key":"6_CR29","doi-asserted-by":"publisher","first-page":"8366","DOI":"10.1021\/ac202016x","volume":"83","author":"LS Eberlin","year":"2011","unstructured":"Eberlin LS, Liu X, Ferreira CR, Santagata S, Agar NYR, Cooks RG (2011b) Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections. Anal Chem 83:8366\u20138371","journal-title":"Anal Chem"},{"key":"6_CR30","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1073\/pnas.1215687110","volume":"110","author":"LS Eberlin","year":"2013","unstructured":"Eberlin LS, Norton I, Orringer D, Dunn IF, Liu X, Ide JL, Jarmusch AK, Ligon KL, Jolesz FA, Golby AJ, Santagata S, Agar NYR, Cooks RG (2013) Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Proc Natl Acad Sci 110:1611\u20131616","journal-title":"Proc Natl Acad Sci"},{"key":"6_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/(SICI)1098-2787(1998)17:1<1::AID-MAS1>3.0.CO;2-K","volume":"17","author":"AG Marshall","year":"1998","unstructured":"Marshall AG, Hendrickson CL, Jackson GS (1998) Fourier transform ion cyclotron resonance mass spectrometry: a primer. Mass Spectrom Rev 17:1\u201335","journal-title":"Mass Spectrom Rev"},{"key":"6_CR32","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1021\/ac0349680","volume":"76","author":"M Rujoi","year":"2004","unstructured":"Rujoi M, Estrada R, Yappert MC (2004) In situ MALDI-TOF MS regional analysis of neutral phospholipids in lens tissue. Anal Chem 76:1657\u20131663","journal-title":"Anal Chem"},{"key":"6_CR33","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1152\/physrev.2001.81.4.1689","volume":"81","author":"JCM Holthuis","year":"2001","unstructured":"Holthuis JCM, Pomorski T, Raggers RJ, Sprong H, Van Meer G (2001) The organizing potential of sphingolipids in intracellular membrane transport. Physiol Rev 81:1689\u20131723","journal-title":"Physiol Rev"},{"key":"6_CR34","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S1043-6618(03)00049-5","volume":"47","author":"R Buccoliero","year":"2003","unstructured":"Buccoliero R, Futerman AH (2003) The roles of ceramide and complex sphingolipids in neuronal cell function. Pharmacol Res 47:409\u2013419","journal-title":"Pharmacol Res"},{"key":"6_CR35","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.4155\/bio.12.251","volume":"4","author":"S Castellino","year":"2012","unstructured":"Castellino S (2012) MALDI imaging MS analysis of drug distribution in tissue: the right time!(?). Bioanalysis 4:2549\u20132551","journal-title":"Bioanalysis"},{"key":"6_CR36","doi-asserted-by":"publisher","first-page":"366","DOI":"10.2307\/3576744","volume":"106","author":"JS Rasey","year":"1986","unstructured":"Rasey JS, Krohn KA, Grunbaum Z, Spence AM, Menard TW, Wade RA (1986) Synthesis, biodistribution, and autoradiography of radiolabeled S-2-(3-methylaminopropylamino)ethylphosphorothioic acid (WR-3689). Radiat Res 106:366\u2013379","journal-title":"Radiat Res"},{"key":"6_CR37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1208\/s12248-009-9158-4","volume":"12","author":"EG Solon","year":"2009","unstructured":"Solon EG, Schweitzer A, Stoeckli M, Prideaux B (2009) Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development. AAPS J 12:11\u201326","journal-title":"AAPS J"},{"key":"6_CR38","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrd1007","volume":"2","author":"M Rudin","year":"2003","unstructured":"Rudin M, Weissleder R (2003) Molecular imaging in drug discovery and development. Nat Rev Drug Discov 2:123\u2013131","journal-title":"Nat Rev Drug Discov"},{"key":"6_CR39","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.4155\/bio.11.232","volume":"3","author":"S Castellino","year":"2011","unstructured":"Castellino S, Groseclose MR, Wagner D (2011) MALDI imaging mass spectrometry: bridging biology and chemistry in drug development. Bioanalysis 3:2427\u20132441","journal-title":"Bioanalysis"},{"key":"6_CR40","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1021\/tx3004196","volume":"26","author":"S Castellino","year":"2013","unstructured":"Castellino S, Groseclose MR, Sigafoos J, Wagner D, De Serres M, Polli JW, Romach E, Myer J, Hamilton B (2013) Central nervous system disposition and metabolism of fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and matrix-assisted laser desorption\/ionization imaging MS investigation into central nervous system toxicity. Chem Res Toxicol 26:241\u2013251","journal-title":"Chem Res Toxicol"},{"key":"6_CR41","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/S1359-6446(05)03458-6","volume":"10","author":"SS Rubakhin","year":"2005","unstructured":"Rubakhin SS, Jurchen JC, Monroe EB, Sweedler JV (2005) Imaging mass spectrometry: fundamentals and applications to drug discovery. Drug Discovery Today 10:823\u2013837","journal-title":"Drug Discovery Today"},{"key":"6_CR42","doi-asserted-by":"publisher","first-page":"e72532","DOI":"10.1371\/journal.pone.0072532","volume":"8","author":"L Morosi","year":"2013","unstructured":"Morosi L, Spinelli P, Zucchetti M, Pretto F, Carr\u00e0 A, D\u2019Incalci M, Giavazzi R, Davoli E (2013) Determination of paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging. PLoS One 8:e72532","journal-title":"PLoS One"},{"key":"6_CR43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1749-6632.2012.06467.x","volume":"1250","author":"RA Gatti","year":"2012","unstructured":"Gatti RA (2012) SMRT compounds correct nonsense mutations in primary immunodeficiency and other genetic models. Ann N Y Acad Sci 1250:33\u201340","journal-title":"Ann N Y Acad Sci"},{"key":"6_CR44","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.dnarep.2004.04.010","volume":"3","author":"HH Chun","year":"2004","unstructured":"Chun HH, Gatti RA (2004) Ataxia-telangiectasia, an evolving phenotype. DNA Repair (Amst) 3:1187\u20131196","journal-title":"DNA Repair (Amst)"},{"key":"6_CR45","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ymgme.2003.09.008","volume":"80","author":"HH Chun","year":"2003","unstructured":"Chun HH, Sun X, Nahas SA, Teraoka S, Lai C-H, Concannon P, Gatti RA (2003) Improved diagnostic testing for ataxia\u2013telangiectasia by immunoblotting of nuclear lysates for ATM protein expression. Mol Gen Metab 80:437\u2013443","journal-title":"Mol Gen Metab"},{"key":"6_CR46","first-page":"573","volume":"39","author":"M Swift","year":"1986","unstructured":"Swift M, Morrell D, Cromartie E, Chamberlin AR, Skolnick MH, Bishop DT (1986) The incidence and gene frequency of ataxia-telangiectasia in the United States. Am J Hum Genet 39:573\u2013583","journal-title":"Am J Hum Genet"},{"key":"6_CR47","doi-asserted-by":"publisher","first-page":"6437","DOI":"10.1093\/emboj\/17.22.6437","volume":"17","author":"S Yoshizawa","year":"1998","unstructured":"Yoshizawa S, Fourmy D, Puglisi JD (1998) Structural origins of gentamicin antibiotic action. EMBO J 17:6437\u20136448","journal-title":"EMBO J"},{"key":"6_CR48","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1046\/j.1365-201x.1999.00618.x","volume":"167","author":"ER Barton-Davis","year":"1999","unstructured":"Barton-Davis ER, Shoturma DI, Sweeney HL (1999) Contribution of satellite cells to IGF-I induced hypertrophy of skeletal muscle. Acta Physiol Scand 167:301\u2013305","journal-title":"Acta Physiol Scand"},{"key":"6_CR49","doi-asserted-by":"publisher","first-page":"15676","DOI":"10.1073\/pnas.0405155101","volume":"101","author":"CH Lai","year":"2004","unstructured":"Lai CH, Chun HH, Nahas SA, Mitui M, Gamo KM, Du L, Gatti RA (2004) Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A 101:15676\u201315681","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6_CR50","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/sj.clpt.6100012","volume":"81","author":"LV Zingman","year":"2007","unstructured":"Zingman LV, Park S, Olson TM, Alekseev AE, Terzic A (2007) Aminoglycoside-induced translational read-through in disease: overcoming nonsense mutations by pharmacogenetic therapy. Clin Pharmacol Ther 81:99\u2013103","journal-title":"Clin Pharmacol Ther"},{"key":"6_CR51","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1084\/jem.20081940","volume":"206","author":"L Du","year":"2009","unstructured":"Du L, Damoiseaux R, Nahas S, Gao K, Hu H, Pollard JM, Goldstine J, Jung ME, Henning SM, Bertoni C, Gatti RA (2009) Nonaminoglycoside compounds induce readthrough of nonsense mutations. J Exp Med 206:2285\u20132297","journal-title":"J Exp Med"},{"key":"6_CR52","doi-asserted-by":"crossref","unstructured":"Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H, Gatti RA (2013) A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther 21:1653\u20131660","DOI":"10.1038\/mt.2013.150"},{"key":"6_CR53","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ijms.2006.09.012","volume":"260","author":"M Zoriy","year":"2007","unstructured":"Zoriy M, Matusch A, Spruss T, Becker JS (2007) Laser ablation inductively coupled plasma mass spectrometry for imaging of copper, zinc, and platinum in thin sections of a kidney from a mouse treated with cis-platin. Int J Mass Spectrom 260:102\u2013106","journal-title":"Int J Mass Spectrom"},{"key":"6_CR54","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.sab.2007.11.030","volume":"63","author":"MV Zoriy","year":"2008","unstructured":"Zoriy MV, Dehnhardt M, Matusch A, Becker JS (2008) Comparative imaging of P, S, Fe, Cu, Zn and C in thin sections of rat brain tumor as well as control tissues by laser ablation inductively coupled plasma mass spectrometry. Spectrochim Acta Part B 63:375\u2013382","journal-title":"Spectrochim Acta Part B"},{"key":"6_CR55","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1021\/nn100690m","volume":"4","author":"H Meng","year":"2010","unstructured":"Meng H, Liong M, Xia T, Li Z, Ji Z, Zink JI, Nel AE (2010) Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano 4:4539\u20134550","journal-title":"ACS Nano"},{"key":"6_CR56","doi-asserted-by":"publisher","first-page":"12564","DOI":"10.1021\/ja406553f","volume":"135","author":"B Yan","year":"2013","unstructured":"Yan B, Kim ST, Kim CS, Saha K, Moyano DF, Xing Y, Jiang Y, Roberts AL, Alfonso FS, Rotello VM, Vachet RW (2013) Multiplexed imaging of nanoparticles in tissues using laser desorption\/ionization mass spectrometry. J Am Chem Soc 135:12564\u201312567","journal-title":"J Am Chem Soc"},{"key":"6_CR57","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.1021\/ac301156f","volume":"84","author":"J Lear","year":"2012","unstructured":"Lear J, Hare DJ, Fryer F, Adlard PA, Finkelstein DI, Doble PA (2012) High-resolution elemental bioimaging of Ca, Mn, Fe, Co, Cu, and Zn employing LA-ICP-MS and hydrogen reaction gas. Anal Chem 84:6707\u20136714","journal-title":"Anal Chem"},{"key":"6_CR58","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ab.2005.08.024","volume":"346","author":"RW Hutchinson","year":"2005","unstructured":"Hutchinson RW, Cox AG, Mcleod CW, Marshall PS, Harper A, Dawson EL, Howlett DR (2005) Imaging and spatial distribution of \u03b2-amyloid peptide and metal ions in Alzheimer\u2019s plaques by laser ablation\u2013inductively coupled plasma\u2013mass spectrometry. Anal Biochem 346:225\u2013233","journal-title":"Anal Biochem"}],"container-title":["Advances in Experimental Medicine and Biology","Advancements of Mass Spectrometry in Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-29437-1_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:55:39Z","timestamp":1792601739000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-032-29437-1_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032294364","9783032294371"],"references-count":58,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-29437-1_6","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"23 January 2027","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}