{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:15:33Z","timestamp":1773422133999,"version":"3.50.1"},"publisher-location":"Vienna","reference-count":25,"publisher":"Springer Vienna","isbn-type":[{"value":"9783211289273","type":"print"},{"value":"9783211452950","type":"electronic"}],"license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006]]},"DOI":"10.1007\/978-3-211-45295-0_71","type":"book-chapter","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T13:23:35Z","timestamp":1164201815000},"page":"477-484","source":"Crossref","is-referenced-by-count":8,"title":["The discovery of the pressor effect of DOPS and its blunting by decarboxylase inhibitors"],"prefix":"10.1007","author":[{"given":"H.","family":"Kaufmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"12","key":"71_CR1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.2042-7158.1981.tb13929.x","volume":"33","author":"H. Araki","year":"1981","unstructured":"Araki H, Tanaka C, et al. (1981) Pressor effect of L-threo-3,4-dihydroxyphenylserine in rats. J Pharm Pharmacol 33(12): 772\u2013777","journal-title":"J Pharm Pharmacol"},{"issue":"2","key":"71_CR2","first-page":"523","volume":"193","author":"J. Bartholini","year":"1975","unstructured":"Bartholini J, Constantinidis J, et al. (1975) The stereoisomers of 3,4-dihydroxyphenylserine as precursors of norepinephrine. J Pharmacol Exp Ther 193(2): 523\u2013532","journal-title":"J Pharmacol Exp Ther"},{"issue":"8569","key":"71_CR3","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/S0140-6736(87)91317-1","volume":"2","author":"I. Biaggioni","year":"1987","unstructured":"Biaggioni I, Robertson D (1987) Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency. Lancet 2(8569): 1170\u20131172","journal-title":"Lancet"},{"issue":"3\u20134","key":"71_CR4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/BF01252816","volume":"58","author":"W. Birkmayer","year":"1983","unstructured":"Birkmayer W, Birkmayer G, et al. (1983) DL-3,4-threo-DOPS in Parkinson\u2019s disease: effects on orthostatic hypotension and dizziness. J Neural Transm 58(3\u20134): 305\u2013313","journal-title":"J Neural Transm"},{"issue":"3","key":"71_CR5","first-page":"431","volume":"5","author":"H. Blaschko","year":"1950","unstructured":"Blaschko H, Burn JH, et al. (1950) The formation of noradrenaline from dihydroxyphenylserine. Br J Pharmacol 5(3): 431\u2013437","journal-title":"Br J Pharmacol"},{"key":"71_CR6","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1212\/01.wnl.0000178980.83477.14","volume":"65","author":"C.H. Gibbons","year":"2005","unstructured":"Gibbons CH, Vernino SA, Kaufmann H, Freeman R (2005) DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy. Neurology 65: 1104\u20131106","journal-title":"Neurology"},{"issue":"9","key":"71_CR7","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1212\/WNL.53.9.2151","volume":"53","author":"R. Freeman","year":"1999","unstructured":"Freeman R, Landsberg L, et al. (1999) The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial. Neurology 53(9):2151\u20132157","journal-title":"Neurology"},{"key":"71_CR8","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1172\/JCI111134","volume":"72","author":"D. Goldstein","year":"1983","unstructured":"Goldstein D, Horwitz D, et al. (1983) Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension. J Clin Invest 72: 1748\u20131758","journal-title":"J Clin Invest"},{"issue":"10","key":"71_CR9","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1056\/NEJM199703063361004","volume":"336","author":"D.S. Goldstein","year":"1997","unstructured":"Goldstein DS, Holmes C, et al. (1997) Sympathetic cardioneuropathy in dysautonomias. N Engl J Med 336(10): 696\u2013702","journal-title":"N Engl J Med"},{"issue":"6","key":"71_CR10","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s10286-004-0221-z","volume":"14","author":"D.S. Goldstein","year":"2004","unstructured":"Goldstein DS, Holmes C, et al. (2004) Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure. Clin Auton Res 14(6): 363\u2013368","journal-title":"Clin Auton Res"},{"issue":"2","key":"71_CR11","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s004010050693","volume":"94","author":"K. Hague","year":"1997","unstructured":"Hague K, Lento P, et al. (1997) The distribution of Lewy bodies in pure autonomic failure: autopsy findings and review of the literature. Acta Neuropathol (Berl) 94(2): 192\u2013196","journal-title":"Acta Neuropathol"},{"issue":"3","key":"71_CR12","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/clpt.1984.179","volume":"36","author":"R.D. Hoeldtke","year":"1984","unstructured":"Hoeldtke RD, Cilmi KM, et al. (1984) DL-Threo-3,4-dihydroxyphenylserine does not exert a pressor effect in orthostatic hypotension. Clin Pharmacol Ther 36(3): 302\u2013306","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"71_CR13","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1254\/jjp.26.380","volume":"26","author":"C. Inagaki","year":"1976","unstructured":"Inagaki C, Fujiwara H, et al. (1976) Inhibitory effect of (+)threo-3,4-dihydroxy-phenylserine (DOPS) on decarboxylation of (\u2212)threo-dops. Jpn J Pharmacol 26(3): 380\u2013382","journal-title":"Jpn J Pharmacol"},{"issue":"7","key":"71_CR14","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1212\/WNL.38.7.1091","volume":"38","author":"T. Kachi","year":"1988","unstructured":"Kachi T, Iwase S, et al. (1988) Effect of L-threo-3,4-dihydroxyphenylserine on muscle sympathetic nerve activities in Shy-Drager syndrome. Neurology 38(7): 1091\u20131094","journal-title":"Neurology"},{"issue":"18","key":"71_CR15","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1016\/0006-2952(87)90223-1","volume":"36","author":"T. Kato","year":"1987","unstructured":"Kato T, Karai N, et al. (1987) Studies on the activity of L-threo-3,4-dihydroxyphenylserine (DOPS) as a catecholamine precursor in the brain. Comparison with that of L-dopa. Biochem Pharmacol 36(18): 3051\u20133057","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"71_CR16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1055\/s-2004-817719","volume":"23","author":"H. Kaufmann","year":"2003","unstructured":"Kaufmann H, Biaggioni I (2003) Autonomic failure in neurodegenerative disorders. Semin Neurol 23(4): 351\u2013363","journal-title":"Semin Neurol"},{"issue":"2","key":"71_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/BF02260889","volume":"3","author":"H. Kaufmann","year":"1991","unstructured":"Kaufmann H, Oribe E, et al. (1991) Differential effect of L-threo-3,4-dihydroxyphenylserine in pure autonomic failure and multiple system atrophy with autonomic failure. J Neural Transm (PD Sect) 3(2): 143\u2013148","journal-title":"J Neural Transm (PD Sect)"},{"issue":"6","key":"71_CR18","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1161\/01.CIR.0000083721.49847.D7","volume":"108","author":"H. Kaufmann","year":"2003","unstructured":"Kaufmann H, Saadia D, et al. (2003) Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation 108(6): 724\u2013728","journal-title":"Circulation"},{"issue":"2","key":"71_CR19","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/ajmg.10196","volume":"108","author":"C.H. Kim","year":"2002","unstructured":"Kim CH, Zabetian CP, et al. (2002) Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency. Am J Med Genet 108(2): 140\u2013147","journal-title":"Am J Med Genet"},{"key":"71_CR20","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(87)91318-3","volume":"2","author":"A.J. Veld","year":"1987","unstructured":"Man in\u2019t Veld AJ, Boomsma F, et al. (1987) Effect of unnatural noradrenaline precursor on sympathetic control and orthostatic hypotension in dopamine-beta-hydroxylase defficiency. Lancet 2: 1172\u20131175","journal-title":"Lancet"},{"issue":"6","key":"71_CR21","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1212\/WNL.36.6.739","volume":"36","author":"J.G. Nutt","year":"1986","unstructured":"Nutt JG, Woodward WR (1986) Levodopa pharmacokinetics and pharmacodynamics in fluctuating parkinsonian patients. Neurology 36(6): 739\u2013744","journal-title":"Neurology"},{"issue":"1","key":"71_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.31.1.1","volume":"31","author":"R.J. Polinsky","year":"1981","unstructured":"Polinsky RJ, Kopin IJ, et al. (1981) Pharmacologic distinction of different orthostatic hypotension syndromes. Neurology 31(1): 1\u20137","journal-title":"Neurology"},{"issue":"1","key":"71_CR23","first-page":"127","volume":"6","author":"C.G. Schmiterlow","year":"1951","unstructured":"Schmiterlow CG (1951) The formation in vivo of noradrenaline from 3:4-dihydroxyphenylserine (noradrenaline carboxylic acid). Br J Pharmacol 6(1): 127\u2013134","journal-title":"Br J Pharmacol"},{"issue":"6","key":"71_CR24","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/BF00570160","volume":"17","author":"T. Suzuki","year":"1980","unstructured":"Suzuki T, Higa S, et al. (1980) Effect of infused L-threo-3,4-dihydroxyphenylserine on adrenergic activity in patients with familial amyloid polyneuropathy. Eur J Clin Pharmacol 17(6): 429\u2013435","journal-title":"Eur J Clin Pharmacol"},{"issue":"6","key":"71_CR25","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1212\/WNL.50.6.1806","volume":"50","author":"S. Vernino","year":"1998","unstructured":"Vernino S, Adamski J, et al. (1998) Neuronal nicotinic ACh receptor antibody in subacute autonomic neuropathy and cancer-related syndromes. Neurology 50(6): 1806\u20131813","journal-title":"Neurology"}],"container-title":["Parkinson\u2019s Disease and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-211-45295-0_71","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T04:06:00Z","timestamp":1557979560000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-211-45295-0_71"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"ISBN":["9783211289273","9783211452950"],"references-count":25,"URL":"https:\/\/doi.org\/10.1007\/978-3-211-45295-0_71","relation":{},"subject":[],"published":{"date-parts":[[2006]]}}}