{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:45:53Z","timestamp":1778226353733,"version":"3.51.4"},"publisher-location":"Cham","reference-count":32,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319081700","type":"print"},{"value":"9783319081717","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-3-319-08171-7_17","type":"book-chapter","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T12:41:09Z","timestamp":1403527269000},"page":"188-199","source":"Crossref","is-referenced-by-count":2,"title":["Drug Target Identification Based on Structural Output Controllability of Complex Networks"],"prefix":"10.1007","author":[{"given":"Lin","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Xiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"17_CR1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/nrd1202","volume":"2","author":"M.A. Lindsay","year":"2003","unstructured":"Lindsay, M.A.: Target discovery. Nat. Rev. Drug. Discov.\u00a02, 831\u2013838 (2003)","journal-title":"Nat. Rev. Drug. Discov."},{"key":"17_CR2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.tips.2005.02.007","volume":"26","author":"P. Csermely","year":"2005","unstructured":"Csermely, P., Agoston, V., Pongor, S.: The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol. Sci.\u00a026, 178\u2013182 (2005)","journal-title":"Trends Pharmacol. Sci."},{"key":"17_CR3","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/msb.2008.60","volume":"4","author":"K. Yang","year":"2008","unstructured":"Yang, K., Bai, H., Ouyang, Q., Lai, L., Tang, C.: Finding multiple target optimal intervention in diseaserelated molecular network. Molecular Systems Biology\u00a04, 228 (2008)","journal-title":"Molecular Systems Biology"},{"issue":"12","key":"17_CR4","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1158\/1535-7163.MCT-10-0642","volume":"9","author":"A.S. Azmi","year":"2010","unstructured":"Azmi, A.S., Wang, Z., Philip, P.A., Mohammad, R.M., Sarkar, F.H.: Proof of concept: Network and systems biology approaches aid in the discovery of potent anticancer drug combinations. Mol. Cancer Ther.\u00a09(12), 3137\u20133144 (2010)","journal-title":"Mol. Cancer Ther."},{"key":"17_CR5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.ymeth.2012.06.003","volume":"57","author":"M. Kotlyar","year":"2012","unstructured":"Kotlyar, M., Fortney, K., Jurisica, I.: Network-based characterization of drug-regulated genes, drug targets, and toxicity. Methods\u00a057, 499\u2013507 (2012)","journal-title":"Methods"},{"key":"17_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrg2918","volume":"12","author":"A. Barab\u00e1si","year":"2011","unstructured":"Barab\u00e1si, A., Gulbahce, N., Loscalzo, J.: Network medicine: a network-based approach to human disease. Nature Reviews Genetics\u00a012, 55\u201368 (2011)","journal-title":"Nature Reviews Genetics"},{"key":"17_CR7","doi-asserted-by":"crossref","unstructured":"Chen, L., Wang, R., Zhang, X.: Biomolecular Networks: Methods and Applications in Systems Biology. Wiley (2009)","DOI":"10.1002\/9780470488065"},{"issue":"8","key":"17_CR8","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1136\/jmg.2006.041376","volume":"43","author":"M. Oti","year":"2006","unstructured":"Oti, M., Snel, B., Huynen, M.A., Brunner, H.G.: Predicting disease genes using protein-protein interactions. J. Med. Genet.\u00a043(8), 691\u2013698 (2006)","journal-title":"J. Med. Genet."},{"issue":"2","key":"17_CR9","first-page":"188","volume":"8","author":"E.B. Akker van den","year":"2011","unstructured":"van den Akker, E.B., Verbruggen, B., Heijmans, B., Beekman, M., Kok, J., Slagboom, P., Reinders, M.J.: Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis. J. Integr. Bioinform.\u00a08(2), 188 (2011)","journal-title":"J. Integr. Bioinform."},{"key":"17_CR10","doi-asserted-by":"crossref","unstructured":"Vanunu, O., Magger, O., Ruppin, E., Shlomi, T., Sharan, R.: Associating genes and protein complexes with disease via network propagation. PLoS Comput. Biol. 6(1) (2010)","DOI":"10.1371\/journal.pcbi.1000641"},{"key":"17_CR11","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/clpt.2008.129","volume":"84","author":"W.C. Hwang","year":"2008","unstructured":"Hwang, W.C., Zhang, A., Ramanathan, M.: Identification of information flow-modulating drug targets: A novel bridging paradigm for drug discovery. Clinical Pharmacology & Therapeutics\u00a084, 563\u2013572 (2008)","journal-title":"Clinical Pharmacology & Therapeutics"},{"issue":"suppl. 1","key":"17_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1752-0509-5-S1-S11","volume":"5","author":"Z. Li","year":"2011","unstructured":"Li, Z., Wang, R.-S., Zhang, X.-S.: Two-stage flux balance analysis of metabolic networks for drug target identification. BMC Systems Biology\u00a05(suppl. 1), 11 (2011)","journal-title":"BMC Systems Biology"},{"issue":"6","key":"17_CR13","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1049\/iet-syb.2008.0166","volume":"3","author":"Z. Li","year":"2009","unstructured":"Li, Z., Wang, R.S., Zhang, X.S., Chen, L.: Detecting drug targets with minimum side effects in metabolic networks. IET Syst. Biol.\u00a03(6), 523\u2013533 (2009)","journal-title":"IET Syst. Biol."},{"issue":"suppl. 2","key":"17_CR14","first-page":"57","volume":"4","author":"Z. Wu","year":"2010","unstructured":"Wu, Z., Zhao, X.M., Chen, L.: A systems biology approach to identify effective cocktail drugs. BMC Systems Biology\u00a04(suppl. 2), 57 (2010)","journal-title":"BMC Systems Biology"},{"key":"17_CR15","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/srep02223","volume":"3","author":"J. Kim","year":"2013","unstructured":"Kim, J., Park, S.M., Cho, K.H.: Discovery of a kernel for controlling biomolecular regulatory networks. Sci. Rep.\u00a03, 2223 (2013)","journal-title":"Sci. Rep."},{"key":"17_CR16","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1038\/ncomms2939","volume":"4","author":"S.P. Cornelius","year":"2013","unstructured":"Cornelius, S.P., Kath, W.L., Motter, A.E.: Realistic control of network dynamics. Nat. Commun.\u00a04, 1942 (2013)","journal-title":"Nat. Commun."},{"key":"17_CR17","doi-asserted-by":"crossref","unstructured":"Lin, C.: Structural controllability. IEEE Trans. Auto. Contr.\u00a0AC-19, 201\u2013208 (1974)","DOI":"10.1109\/TAC.1974.1100557"},{"key":"17_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nature10011","volume":"473","author":"Y. Liu","year":"2011","unstructured":"Liu, Y., Slotine, J., Barab\u00e1si, A.: Controllability of complex networks. Nature\u00a0473, 167\u2013173 (2011)","journal-title":"Nature"},{"key":"17_CR19","doi-asserted-by":"crossref","unstructured":"Hosoe, S.: Determination of generic dimensions of controllable subspaces and its application. IEEE Trans. Auto. Contr.\u00a0AC-25, 1192\u20131196 (1980)","DOI":"10.1109\/TAC.1980.1102506"},{"key":"17_CR20","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1109\/9.58507","volume":"AC-35","author":"K. Murota","year":"1990","unstructured":"Murota, K., Poljak, S.: Note on a graph-theoretic criterion for structural output controllability. IEEE Trans. Auto. Contr.\u00a0AC-35, 939\u2013942 (1990)","journal-title":"IEEE Trans. Auto. Contr."},{"key":"17_CR21","unstructured":"Slotine, J., Li, W.: Applied Nonlinear Control. Prentice-Hall (1991)"},{"key":"17_CR22","unstructured":"Nise, N.: Control System Engineering, 6th edn. Wiley (2011)"},{"key":"17_CR23","first-page":"152","volume":"1","author":"R. Kalman","year":"1962","unstructured":"Kalman, R.: Mathematical description of linear dynamical systems. J.S.I.A.M Control Ser. A\u00a01, 152\u2013192 (1962)","journal-title":"J.S.I.A.M Control Ser. A"},{"key":"17_CR24","unstructured":"Ogata, K.: Modern Control Engineering, 3rd edn. Prentice-Hall (1997)"},{"key":"17_CR25","unstructured":"Wu, F.X., Wu, L., Wang, J., Liu, J., Chen, L.: Transittability of complex networks and its applications to regulatory biomolecular networks. Sci. Rep. (accepted)"},{"key":"17_CR26","unstructured":"Jungnickel, D.: Graphs, Networks and Algorithms, 3rd edn. Springer (2005)"},{"key":"17_CR27","doi-asserted-by":"crossref","unstructured":"Liu, Y.Y., Slotine, J.J., Barab\u00e1si, A.L.: Control centrality and hierarchical structure in complex networks. PLoS ONE\u00a07(9), e44459 (2012)","DOI":"10.1371\/journal.pone.0044459"},{"key":"17_CR28","doi-asserted-by":"crossref","unstructured":"Cowan, N.J., Chastain, E.J., Vilhena, D.A., Freudenberg, J.S., Bergstrom, C.T.: Nodal dynamics, not degree distributions, determine the structural controllability of complex networks. PLoS ONE\u00a07(6), e38398 (2012)","DOI":"10.1371\/journal.pone.0038398"},{"issue":"1","key":"17_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M. Kanehisa","year":"2000","unstructured":"Kanehisa, M., Goto, S.: Kegg: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res.\u00a028(1), 27\u201330 (2000)","journal-title":"Nucleic Acids Res."},{"key":"17_CR30","doi-asserted-by":"crossref","unstructured":"Sridhar, P., Song, B., Kahveci, T., Ranka, S.: Mining metabolic network for optimal drug targets. In: Pac. Symp. Biocomput., vol.\u00a013, pp. 291\u2013302 (2008)","DOI":"10.1142\/9789812776136_0029"},{"issue":"3","key":"17_CR31","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1124\/jpet.106.115436","volume":"321","author":"N.L. Rao","year":"2007","unstructured":"Rao, N.L., Dunford, P.J., Xue, X., Jiang, X., Lundeen, K.A., Coles, F., Riley, J.P., Williams, K.N., Grice, C.A., Edwards, J.P., Karlsson, L., Fourie, A.M.: Anti-inflammatory activity of a potent, selective leukotriene a4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. J. Pharmacol. Exp. Ther.\u00a0321(3), 1154\u20131160 (2007)","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"17_CR32","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S1081-1206(10)62265-X","volume":"87","author":"M.J. Torres-Galv\u00e1n","year":"2001","unstructured":"Torres-Galv\u00e1n, M.J., Ortega, N., S\u00e1nchez-Garc\u00eda, F., Blanco, C., Carrillo, T., Quiralte, J.: Ltc4-synthase a-444c polymorphism: lack of association with nsaid-induced isolated periorbital angioedema in a Spanish population. Ann. Allergy Asthma Immunol.\u00a087(6), 506\u2013510 (2001)","journal-title":"Ann. Allergy Asthma Immunol."}],"container-title":["Lecture Notes in Computer Science","Bioinformatics Research and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-08171-7_17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T12:35:35Z","timestamp":1746275735000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-08171-7_17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9783319081700","9783319081717"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-08171-7_17","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}