{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T05:42:32Z","timestamp":1786858952317,"version":"3.56.0"},"publisher-location":"Cham","reference-count":20,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319129815","type":"print"},{"value":"9783319129822","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-3-319-12982-2_5","type":"book-chapter","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T06:26:34Z","timestamp":1413786394000},"page":"61-72","source":"Crossref","is-referenced-by-count":37,"title":["Uncertainty Analysis for Non-identifiable Dynamical Systems: Profile Likelihoods, Bootstrapping and More"],"prefix":"10.1007","author":[{"given":"Fabian","family":"Fr\u00f6hlich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian J.","family":"Theis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hasenauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5_CR1","doi-asserted-by":"crossref","unstructured":"Raue, A., Kreutz, C., Maiwald, T., Bachmann, J., Schilling, M., Klingm\u00fcller, U., Timmer, J.: Structural and Practical Identifiability Analysis of Partially Observed Dynamical Models by Exploiting the Profile Likelihood.. Bioinformatics\u00a025(15), 1923\u20131929 (2009)","DOI":"10.1093\/bioinformatics\/btp358"},{"issue":"8","key":"5_CR2","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/bioinformatics\/bts092","volume":"28","author":"J. Vanlier","year":"2012","unstructured":"Vanlier, J., Tiemann, C.A., Hilbers, P.A.J., van Riel, N.A.W.: A Bayesian Approach to Targeted Experiment Design. Bioinformatics\u00a028(8), 1136\u20131142 (2012)","journal-title":"Bioinformatics"},{"issue":"8","key":"5_CR3","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1093\/bioinformatics\/bts088","volume":"28","author":"J. Vanlier","year":"2012","unstructured":"Vanlier, J., Tiemann, C.A., Hilbers, P.A.J., van Riel, N.A.W.: An Integrated Strategy for Prediction Uncertainty Analysis. Bioinformatics (Oxford, England)\u00a028(8), 1130\u20131135 (2012)","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"11","key":"5_CR4","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.1111\/febs.12276","volume":"280","author":"C. Kreutz","year":"2013","unstructured":"Kreutz, C., Raue, A., Kaschek, D., Timmer, J.: Profile Likelihood in Systems Biology. The FEBS Journal\u00a0280(11), 2564\u20132571 (2013)","journal-title":"The FEBS Journal"},{"issue":"5","key":"5_CR5","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.ymben.2006.04.003","volume":"8","author":"M. Joshi","year":"2006","unstructured":"Joshi, M., Seidel-Morgenstern, A., Kremling, A.: Exploiting the Bootstrap Method for Quantifying Parameter Confidence Intervals in Dynamical Systems. Metabolic Engineering\u00a08(5), 447\u2013455 (2006)","journal-title":"Metabolic Engineering"},{"key":"5_CR6","doi-asserted-by":"crossref","unstructured":"Kallenberger, S.M., Beaudouin, J., Claus, J., Fischer, C., Sorger, P.K., Legewie, S., Eils, R.: Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis. Science Signaling 7(316) (2014)","DOI":"10.1126\/scisignal.2004738"},{"issue":"1","key":"5_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1214\/13-BA801","volume":"8","author":"D. Schmidl","year":"2013","unstructured":"Schmidl, D., Czado, C., Hug, S., Theis, F.J.: A Vine-copula Based Adaptive MCMC Sampler for Efficient Inference of Dynamical Systems. Bayesian Analysis\u00a08(1), 1\u201322 (2013)","journal-title":"Bayesian Analysis"},{"key":"5_CR8","doi-asserted-by":"crossref","unstructured":"Raue, A., Kreutz, C., Theis, F.J., Timmer, J.: Joining Forces of Bayesian and Frequentist Methodology: A Study for Inference in the Presence of Non-Identifiability. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 371(1984) (2013)","DOI":"10.1098\/rsta.2011.0544"},{"key":"5_CR9","doi-asserted-by":"crossref","unstructured":"Hock, S., Hasenauer, J., Theis, F.J.: Modeling of 2D Diffusion Processes based on Microscopy Data: Parameter Estimation and Practical Identifiability Analysis. BMC Bioinformatics 14(suppl.7) (2013)","DOI":"10.1186\/1471-2105-14-S10-S7"},{"key":"5_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1752-0509-4-11","volume":"4","author":"E. Balsa-Canto","year":"2010","unstructured":"Balsa-Canto, E., Alonso, A.A., Banga, J.R.: An Iterative Identification Procedure for Dynamic Modeling of Biochemical Networks. BMC Systems Biology\u00a04, 11 (2010)","journal-title":"BMC Systems Biology"},{"key":"5_CR11","doi-asserted-by":"crossref","unstructured":"Raue, A., Schilling, M., Bachmann, J., Matteson, A., Schelke, M., Kaschek, D., Hug, S., Kreutz, C., Harms, B.D., Theis, F.J., Klingm\u00fcller, U., Timmer, J.: Lessons Learned From Quantitative Dynamical Modeling in Systems Biology. PLoS ONE 8(9), e74335 (2013)","DOI":"10.1371\/journal.pone.0074335"},{"issue":"4","key":"5_CR12","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/bioinformatics\/btl522","volume":"23","author":"O.R. Gonzalez","year":"2007","unstructured":"Gonzalez, O.R., K\u00fcper, C., Jung, K., Naval, P.C., Mendoza, E.: Parameter Estimation Using Simulated Annealing for S-System Models of Biochemical Networks. Bioinformatics\u00a023(4), 480\u2013486 (2007)","journal-title":"Bioinformatics"},{"issue":"18","key":"5_CR13","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1016\/j.ces.2009.05.028","volume":"64","author":"D.M. Prata","year":"2009","unstructured":"Prata, D.M., Schwaab, M., Lima, E.L., Pinto, J.C.: Nonlinear Dynamic Data Reconciliation and Parameter Estimation through Particle Swarm Optimization: Application for an Industrial Polypropylene Reactor. Chemical Engineering Science\u00a064(18), 3953\u20133967 (2009)","journal-title":"Chemical Engineering Science"},{"issue":"11","key":"5_CR14","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1101\/gr.1262503","volume":"13","author":"C.G. Moles","year":"2003","unstructured":"Moles, C.G., Mendes, P., Banga, J.R.: Parameter Estimation in Biochemical Pathways: A Comparison of Global Optimization Methods. Genome Research\u00a013(11), 2467\u20132474 (2003)","journal-title":"Genome Research"},{"key":"5_CR15","doi-asserted-by":"crossref","unstructured":"Vaz, A., Vicente, L.: A Particle Swarm Pattern Search Method for Bound Constrained Global Optimization. Journal of Global Optimization, 1\u20136 (2007)","DOI":"10.1007\/s10898-007-9133-5"},{"issue":"2","key":"5_CR16","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1049\/iet-syb.2010.0061","volume":"5","author":"A. Raue","year":"2011","unstructured":"Raue, A., Kreutz, C., Maiwald, T., Klingmuller, U., Timmer, J.: Addressing Parameter Identifiability by Model-Based Experimentation. IET Systems Biology\u00a05(2), 120\u2013130 (2011)","journal-title":"IET Systems Biology"},{"key":"5_CR17","doi-asserted-by":"crossref","unstructured":"Chis, O.T., Banga, J.R., Balsa-Canto, E.: Structural Identifiability of Systems Biology Models: A Critical Comparison of Methods. PLoS ONE 6(11), e27755 (2011)","DOI":"10.1371\/journal.pone.0027755"},{"key":"5_CR18","doi-asserted-by":"crossref","unstructured":"Ramsay, P.H., Scott, D.W.: Multivariate Density Estimation, Theory, Practice, and Visualization. Wiley (1993)","DOI":"10.2307\/1270280"},{"issue":"3","key":"5_CR19","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1073\/pnas.0237333100","volume":"100","author":"I. Swameye","year":"2003","unstructured":"Swameye, I., Muller, T.G., Timmer, J., Sandra, O., Klingmuller, U.: Identification of Nucleocytoplasmic Cycling as a Remote Sensor in Cellular Signaling by Databased Modeling. PNAS\u00a0100(3), 1028\u20131033 (2003)","journal-title":"PNAS"},{"issue":"4","key":"5_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1049\/iet-syb:20070069","volume":"2","author":"E. Balsa-Canto","year":"2008","unstructured":"Balsa-Canto, E., Alvarez-Alonso, A., Banga, J.R.: Computational Procedures for Optimal Experimental Design in Biological Systems. IET Systems Biology\u00a02(4), 163\u2013172 (2008)","journal-title":"IET Systems Biology"}],"container-title":["Lecture Notes in Computer Science","Computational Methods in Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-12982-2_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T14:52:52Z","timestamp":1676904772000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-319-12982-2_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9783319129815","9783319129822"],"references-count":20,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-12982-2_5","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}