{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T16:37:24Z","timestamp":1794501444767,"version":"4.9.1"},"publisher-location":"Cham","reference-count":99,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319181431","type":"print"},{"value":"9783319181448","type":"electronic"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-3-319-18144-8_5","type":"book-chapter","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T11:56:16Z","timestamp":1436529376000},"page":"111-136","source":"Crossref","is-referenced-by-count":16,"title":["Hydrogen Sulfide and Urogenital Tract"],"prefix":"10.1007","author":[{"given":"Roberta d\u2019Emmanuele","family":"di Villa Bianca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5_CR1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","volume":"16","author":"K Abe","year":"1996","unstructured":"Abe K, Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16:1066\u20131071","journal-title":"J Neurosci"},{"key":"5_CR2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/nau.10052","volume":"21","author":"P Abrams","year":"2002","unstructured":"Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, van Kerrebroeck P, Victor A, Wein A (2002) The standardization of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21:167\u2013178","journal-title":"Neurourol Urodyn"},{"key":"5_CR3","doi-asserted-by":"publisher","first-page":"ra87","DOI":"10.1126\/scisignal.2005478","volume":"7","author":"Z Altaany","year":"2014","unstructured":"Altaany Z, Ju Y, Yang G, Wang R (2014) The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide. Sci Signal 7:ra87","journal-title":"Sci Signal"},{"key":"5_CR4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1600-0773.1992.tb00466.x","volume":"70","author":"KE Andersson","year":"1992","unstructured":"Andersson KE (1992) Clinical pharmacology of potassium channel openers. Pharmacol Toxicol 70:244\u2013254","journal-title":"Pharmacol Toxicol"},{"key":"5_CR5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6997(25)00442-9","volume":"45","author":"KE Andersson","year":"1993","unstructured":"Andersson KE (1993) Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 45:253\u2013308","journal-title":"Pharmacol Rev"},{"key":"5_CR6","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1152\/physrev.00038.2003","volume":"84","author":"KE Andersson","year":"2004","unstructured":"Andersson KE, Arner A (2004) Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 84:935\u2013986","journal-title":"Physiol Rev"},{"key":"5_CR7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.bcp.2006.04.003","volume":"72","author":"EL Andrade","year":"2006","unstructured":"Andrade EL, Ferreira J, Andr\u00e9 E, Calixto JB (2006) Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder. Biochem Pharmacol 72:104\u2013114","journal-title":"Biochem Pharmacol"},{"key":"5_CR8","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.bbrc.2003.11.034","volume":"312","author":"J Angulo","year":"2003","unstructured":"Angulo J, Cuevas P, Fern\u00e1ndez A, Gabancho S, Allona A, Mart\u00edn-Morales A, Moncada I, Videla S, S\u00e1enz de Tejada I (2003) Diabetes impairs endothelium-dependent relaxation of human penile vascular tissues mediated by NO and EDHF. Biochem Biophys Res Commun 312:1202\u20131208","journal-title":"Biochem Biophys Res Commun"},{"key":"5_CR9","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1046\/j.1365-2265.2000.01118.x","volume":"53","author":"A Aversa","year":"2000","unstructured":"Aversa A, Isidori AM, De Martino MU, Caprio M, Fabbrini E, Rocchietti-March M, Frajese G, Fabbri A (2000) Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction. Clin Endocrinol (Oxf) 53:517\u2013522","journal-title":"Clin Endocrinol (Oxf)"},{"key":"5_CR10","doi-asserted-by":"publisher","first-page":"12248","DOI":"10.1073\/pnas.0505356102","volume":"102","author":"DM Bautista","year":"2005","unstructured":"Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, H\u00f6gest\u00e4tt ED, Julius D, Jordt SE, Zygmunt PM (2005) Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci USA 102:12248\u201312252","journal-title":"Proc Natl Acad Sci USA"},{"key":"5_CR11","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0090-4295(00)00551-3","volume":"56","author":"AJ Becker","year":"2000","unstructured":"Becker AJ, Uckert S, Stief CG, Truss MC, Machtens S, Scheller F, Knapp WH, Hartmann U, Jonas U (2000) Cavernous and systemic testosterone levels in different phases of human penile erection. Urology 56:125\u2013129","journal-title":"Urology"},{"key":"5_CR12","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0090-4295(01)01226-2","volume":"58","author":"AJ Becker","year":"2001","unstructured":"Becker AJ, Uckert S, Stief CG, Scheller F, Knapp WH, Hartmann U, Jonas U (2001) Cavernous and systemic testosterone plasma levels during different penile conditions in healthy males and patients with erectile dysfunction. Urology 58:435\u2013440","journal-title":"Urology"},{"key":"5_CR13","doi-asserted-by":"crossref","first-page":"C1190","DOI":"10.1152\/ajpcell.1993.264.5.C1190","volume":"264","author":"AD Bonev","year":"1993","unstructured":"Bonev AD, Nelson MT (1993) ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder. Am J Physiol Cell Physiol 264:C1190\u2013C1200","journal-title":"Am J Physiol Cell Physiol"},{"key":"5_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1113\/jphysiol.2005.097311","volume":"570","author":"AF Brading","year":"2006","unstructured":"Brading AF (2006) Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J Physiol 570:13\u201322","journal-title":"J Physiol"},{"issue":"6","key":"5_CR15","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1111\/bph.12740","volume":"172","author":"V Brancaleone","year":"2014","unstructured":"Brancaleone V, Vellecco V, Matassa DS, d\u2019Emmanuele di Villa Bianca R, Sorrentino R, Ianaro A, Bucci M, Esposito F, Cirino G (2014) Crucial role of androgen receptor in vascular H2S biosynthesis induced by testosterone. Br J Pharmacol 172(6):1505\u20131515","journal-title":"Br J Pharmacol"},{"key":"5_CR16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/00004872-200502000-00001","volume":"23","author":"H Brunner","year":"2005","unstructured":"Brunner H, Cockcroft JR, Deanfield J, Donald A, Ferrannini E, Halcox J, Kiowski W, L\u00fcscher TF, Mancia G, Natali A, Oliver JJ, Pessina AC, Rizzoni D, Rossi GP, Salvetti A, Spieker LE, Taddei S, Webb DJ, Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension (2005) Endothelial function and dysfunction. Part II: association with cardiovascular risk factors and diseases. A statement by the working group on endothelins and endothelial factors of the european society of hypertension. J Hypertens 23:233\u2013246","journal-title":"J Hypertens"},{"key":"5_CR17","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.eururo.2008.05.014","volume":"56","author":"M Bucci","year":"2009","unstructured":"Bucci M, Mirone V, Di Lorenzo A, Vellecco V, Roviezzo F, Brancaleone V, Imbimbo C, Cirino G (2009) Hydrogen sulphide is involved in testosterone vascular effect. Eur Urol 56:378\u2013383","journal-title":"Eur Urol"},{"key":"5_CR18","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1161\/ATVBAHA.110.209783","volume":"30","author":"M Bucci","year":"2010","unstructured":"Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Pyriochou A, Roussos C, Roviezzo F, Brancaleone V, Cirino G (2010) Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity. Arterioscler Thromb Vasc Biol 30:1998\u20132004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5_CR19","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0014-2999(00)00388-5","volume":"400","author":"SA Buckner","year":"2000","unstructured":"Buckner SA, Milicic I, Daza A, Davis-Taber R, Scott VE, Sullivan JP, Brioni JD (2000) Pharmacological and molecular analysis of ATP-sensitive K channels in the pig and human detrusor. Eur J Pharmacol 400:287\u2013295","journal-title":"Eur J Pharmacol"},{"key":"5_CR20","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/S0165-6147(02)02050-3","volume":"23","author":"R Busse","year":"2002","unstructured":"Busse R, Edwards G, F\u00e9l\u00e9tou M, Fleming I, Vanhoutte PM, Weston AH (2002) EDHF: bringing the concepts together. Trends Pharmacol Sci 23:374\u2013380","journal-title":"Trends Pharmacol Sci"},{"key":"5_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cardiores.2007.05.026","volume":"76","author":"WJ Cai","year":"2007","unstructured":"Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, Zhu YC (2007) The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovasc Res 76:29\u201340","journal-title":"Cardiovasc Res"},{"issue":"Suppl 2","key":"5_CR22","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1038\/sj.bjp.0706627","volume":"147","author":"GJ Christ","year":"2006","unstructured":"Christ GJ, Hodges S (2006) Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction. Br J Pharmacol 147(Suppl 2):S41\u2013S55","journal-title":"Br J Pharmacol"},{"key":"5_CR23","first-page":"77","volume":"5","author":"GJ Christ","year":"1993","unstructured":"Christ GJ, Brink PR, Melman A, Spray DC (1993) The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human corpus cavernosum smooth muscle. Int J Impot Res 5:77\u201396","journal-title":"Int J Impot Res"},{"key":"5_CR24","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.pharmthera.2005.10.011","volume":"111","author":"G Cirino","year":"2006","unstructured":"Cirino G, Fusco F, Imbimbo C, Mirone V (2006) Pharmacology of erectile dysfunction in man. Pharmacol Ther 111:400\u2013423","journal-title":"Pharmacol Ther"},{"key":"5_CR25","doi-asserted-by":"publisher","first-page":"9161","DOI":"10.1073\/pnas.1202916109","volume":"109","author":"C Coletta","year":"2012","unstructured":"Coletta C, Papapetropoulos A, Erdelyi K, Olah G, M\u00f3dis K, Panopoulos P, Asimakopoulou A, Ger\u00f6 D, Sharina I, Martin E, Szabo C (2012) Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proc Natl Acad Sci USA 109:9161\u20139166","journal-title":"Proc Natl Acad Sci USA"},{"key":"5_CR26","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1073\/pnas.0807974105","volume":"106","author":"R d\u2019Emmanuele di Villa Bianca","year":"2009","unstructured":"d\u2019Emmanuele di Villa Bianca R, Sorrentino R, Maffia P, Mirone V, Imbimbo C, Fusco F, De Palma R, Ignarro LJ, Cirino G (2009) Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. Proc Natl Acad Sci USA 106:4513\u20134518","journal-title":"Proc Natl Acad Sci USA"},{"key":"5_CR27","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1124\/jpet.110.176016","volume":"337","author":"R d\u2019Emmanuele di Villa Bianca","year":"2011","unstructured":"d\u2019Emmanuele di Villa Bianca R, Sorrentino R, Coletta C, Mitidieri E, Rossi A, Vellecco V et al (2011) Hydrogen sulfide-induced dual vascular effect involves arachidonic acid cascade in rat mesenteric arterial bed. J Pharmacol Exp Ther 337:59\u201364","journal-title":"J Pharmacol Exp Ther"},{"key":"5_CR28","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1146\/annurev.pharmtox.41.1.691","volume":"41","author":"WC de Groat","year":"2001","unstructured":"de Groat WC, Yoshimura N (2001) Pharmacology of the lower urinary tract. Annu Rev Pharmacol Toxicol 41:691\u2013721","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"5_CR29","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1016\/j.niox.2013.06.072","volume":"31","author":"A Dikmen","year":"2013","unstructured":"Dikmen A, d\u2019Emmanuele di Villa Bianca R, Mitidieri E, Donnarumma E, Sevin G, Cirino G, Sorrentino R, Yetik-Anacak G (2013) New mechanism for the beneficial effect of sildenafil on erectile function: H2S. Nitric Oxide 31:S38","journal-title":"Nitric Oxide"},{"key":"5_CR30","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1242\/jeb.02376","volume":"209","author":"RA Dombkowski","year":"2006","unstructured":"Dombkowski RA, Doellman MM, Head SK, Olson KR (2006) Hydrogen sulfide mediates hypoxia-induced relaxation of trout urinary bladder smooth muscle. J Exp Biol 209:3234\u20133340","journal-title":"J Exp Biol"},{"key":"5_CR31","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.jacc.2011.06.024","volume":"58","author":"JY Dong","year":"2011","unstructured":"Dong JY, Zhang YH, Qin LQ (2011) Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies. J Am Coll Cardiol 58:1378\u20131385","journal-title":"J Am Coll Cardiol"},{"key":"5_CR32","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.juro.2013.02.103","volume":"190","author":"VS Fernandes","year":"2013","unstructured":"Fernandes VS, Ribeiro AS, Barahona MV, Orensanz LM, Mart\u00ednez-S\u00e1enz A, Recio P, Mart\u00ednez AC, Bustamante S, Carballido J, Garc\u00eda-Sacrist\u00e1n A, Prieto D, Hern\u00e1ndez M (2013a) Hydrogen sulfide mediated inhibitory neurotransmission to the pig bladder neck: role of KATP channels, sensory nerves and calcium signaling. J Urol 190:746\u2013756","journal-title":"J Urol"},{"key":"5_CR33","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.juro.2012.10.006","volume":"189","author":"VS Fernandes","year":"2013","unstructured":"Fernandes VS, Ribeiro AS, Mart\u00ednez MP, Orensanz LM, Barahona MV, Mart\u00ednez-S\u00e1enz A, Recio P, Benedito S, Bustamante S, Carballido J, Garc\u00eda-Sacrist\u00e1n A, Prieto D, Hern\u00e1ndez M (2013b) Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck. J Urol 189:1567\u20131573","journal-title":"J Urol"},{"key":"5_CR34","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.eururo.2012.07.025","volume":"62","author":"F Fusco","year":"2012","unstructured":"Fusco F, d\u2019Emmanuele di Villa Bianca RD, Mitidieri E, Cirino G, Sorrentino R, Mirone V (2012) Sildenafil effect on the human bladder involves the L-cysteine\/hydrogen sulfide pathway: a novel mechanism of action of phosphodiesterase type 5 inhibitors. Eur Urol 62:1174\u20131180","journal-title":"Eur Urol"},{"key":"5_CR35","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/aja.2013.32","volume":"15","author":"JW Gai","year":"2013","unstructured":"Gai JW, Wahafu W, Guo H, Liu M, Wang XC, Xiao YX, Zhang L, Xin ZC, Jin J (2013) Further evidence of endogenous hydrogen sulphide as a mediator of relaxation in human and rat bladder. Asian J Androl 15:692\u2013696","journal-title":"Asian J Androl"},{"key":"5_CR36","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.eururo.2013.08.023","volume":"65","author":"G Gandaglia","year":"2014","unstructured":"Gandaglia G, Briganti A, Jackson G, Kloner RA, Montorsi F, Montorsi P, Vlachopoulos C (2014) A systematic review of the association between erectile dysfunction and cardiovascular disease. Eur Urol 65:968\u2013978","journal-title":"Eur Urol"},{"key":"5_CR37","doi-asserted-by":"publisher","first-page":"R1608","DOI":"10.1152\/ajpregu.00207.2006","volume":"293","author":"B Geng","year":"2007","unstructured":"Geng B, Cui Y, Zhao J, Yu F, Zhu Y, Xu G, Zhang Z, Tang C, Du J (2007) Hydrogen sulfide downregulates the aortic L-arginine\/nitric oxide pathway in rats. Am J Physiol Regul Integr Comp Physiol 293:R1608\u2013R1618","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"5_CR38","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.bcp.2012.01.026","volume":"83","author":"M Ghasemi","year":"2012","unstructured":"Ghasemi M, Dehpour AR, Moore KP, Mani AR (2012) Role of endogenous hydrogen sulfide in neurogenic relaxation of rat corpus cavernosum. Biochem Pharmacol 83:1261\u20131268","journal-title":"Biochem Pharmacol"},{"key":"5_CR39","doi-asserted-by":"publisher","first-page":"777","DOI":"10.2337\/diacare.26.3.777","volume":"26","author":"I Goldstein","year":"2003","unstructured":"Goldstein I, Young JM, Fischer J, Bangerter K, Segerson T, Taylor T (2003) Vardenafil a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care 26:777\u2013783","journal-title":"Diabetes Care"},{"key":"5_CR40","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1517\/14728222.8.5.437","volume":"8","author":"M Gopalakrishnan","year":"2004","unstructured":"Gopalakrishnan M, Shieh CC (2004) Potassium channel subtypes as molecular targets for overactive bladder and other urological disorders. Expert Opin Ther Targets 8:437\u2013458","journal-title":"Expert Opin Ther Targets"},{"key":"5_CR41","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.eururo.2008.04.042","volume":"55","author":"C Gratzke","year":"2009","unstructured":"Gratzke C, Streng T, Waldkirch E, Sigl K, Stief C, Andersson KE, Hedlund P (2009) Transient receptor potential A1 (TRPA1) activity in the human urethra\u2014evidence for a functional role for TRPA1 in the outflow region. Eur Urol 55:696\u2013704","journal-title":"Eur Urol"},{"key":"5_CR42","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1476-5381.2009.00132.x","volume":"157","author":"I Grgic","year":"2009","unstructured":"Grgic I, Kaistha BP, Hoyer J, K\u00f6hler R (2009) Endothelial Ca\u2009+\u2009\u2212activated K+ channels in normal and impaired EDHF-dilator responses\u2013relevance to cardiovascular pathologies and drug discovery. Br J Pharmacol 157:509\u2013526","journal-title":"Br J Pharmacol"},{"key":"5_CR43","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.urology.2011.10.013","volume":"79","author":"H Guo","year":"2012","unstructured":"Guo H, Gai JW, Wang Y, Jin HF, Du JB, Jin J (2012) Characterization of hydrogen sulfide and its synthases, cystathionine \u03b2-synthase and cystathionine \u03b3-lyase, in human prostatic tissue and cells. Urology 79:483, e1-5","journal-title":"Urology"},{"key":"5_CR44","doi-asserted-by":"publisher","first-page":"143763","DOI":"10.1155\/2014\/143763","volume":"2014","author":"G Hackett","year":"2014","unstructured":"Hackett G, Kirby M, Sinclair AJ (2014) Testosterone deficiency, cardiac health, and older men. Int J Endocrinol 2014:143763","journal-title":"Int J Endocrinol"},{"key":"5_CR45","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.eururo.2013.08.048","volume":"65","author":"AM Isidori","year":"2014","unstructured":"Isidori AM, Buvat J, Corona G, Goldstein I, Jannini EA, Lenzi A, Porst H, Salonia A, Traish AM, Maggi M (2014) A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment-a systematic review. Eur Urol 65:99\u2013112","journal-title":"Eur Urol"},{"key":"5_CR46","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1055\/s-0028-1088299","volume":"74","author":"C Jacob","year":"2008","unstructured":"Jacob C, Anwar A, Burkholz T (2008) Perspective on recent developments on sulfur-containing agents and hydrogen sulfide signaling. Planta Med 74:1580\u20131592","journal-title":"Planta Med"},{"key":"5_CR47","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/ars.2009.2894","volume":"12","author":"B Jiang","year":"2010","unstructured":"Jiang B, Tang G, Cao K, Wu L, Wang R (2010) Molecular mechanism for H(2)S-induced activation of K(ATP) channels. Antioxid Redox Signal 12:1167\u20131178","journal-title":"Antioxid Redox Signal"},{"key":"5_CR48","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1124\/jpet.108.140269","volume":"327","author":"S Kajioka","year":"2008","unstructured":"Kajioka S, Nakayama S, Asano H, Seki N, Naito S, Brading AF (2008) Levcromakalim and MgGDP activate small conductance ATP-sensitive K\u2009+\u2009channels of K+ channel pore 6.1\/sulfonylurea receptor 2A in pig detrusor smooth muscle cells: uncoupling of cAMP signal pathways. J Pharmacol Exp Ther 327:114\u2013123","journal-title":"J Pharmacol Exp Ther"},{"key":"5_CR49","unstructured":"Kardong KV (2005) The urogenital system. In: Vertebrates: compartive anatomy, function, evolution. McGraw Hill Higher Education, New York, pp 577\u2013578 (Chapter 14)"},{"key":"5_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1389450013348894","volume":"2","author":"V Karicheti","year":"2001","unstructured":"Karicheti V, Christ GJ (2001) Physiological roles for K+ channels and gap junctions in urogenital smooth muscle: implications for improved understanding of urogenital function, disease and therapy. Curr Drug Targets 2:1\u201320","journal-title":"Curr Drug Targets"},{"key":"5_CR51","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1089\/ars.2013.5308","volume":"20","author":"K Kashfi","year":"2014","unstructured":"Kashfi K (2014) Anti-cancer activity of new designer hydrogen sulfide-donating hybrids. Antioxid Redox Signal 20:831\u2013846","journal-title":"Antioxid Redox Signal"},{"key":"5_CR52","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","volume":"85","author":"K Kashfi","year":"2013","unstructured":"Kashfi K, Olson KR (2013) Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras. Biochem Pharmacol 85:689\u2013703","journal-title":"Biochem Pharmacol"},{"key":"5_CR53","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1016\/j.fertnstert.2010.11.001","volume":"95","author":"J Li","year":"2011","unstructured":"Li J, Li Y, Du Y, Mou K, Sun H, Zang Y, Liu C (2011) Endogenous hydrogen sulfide as a mediator of vas deferens smooth muscle relaxation. Fertil Steril 95:1833\u20131835","journal-title":"Fertil Steril"},{"key":"5_CR54","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1111\/j.1743-6109.2012.02879.x","volume":"9","author":"Y Li","year":"2012","unstructured":"Li Y, Zang Y, Fu S, Zhang H, Gao L, Li J (2012) H2S relaxes vas deferens smooth muscle by modulating the large conductance Ca2\u2009+\u2009\u2212activated K+ (BKCa) channels via a redox mechanism. J Sex Med 9:2806\u20132813","journal-title":"J Sex Med"},{"key":"5_CR55","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/jcmm.12016","volume":"17","author":"L Li","year":"2013","unstructured":"Li L, Fox B, Keeble J, Salto-Tellez M, Winyard PG, Wood ME, Moore PK, Whiteman M (2013) The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. J Cell Mol Med 17:365\u2013376","journal-title":"J Cell Mol Med"},{"key":"5_CR56","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1111\/j.1476-5381.2012.02060.x","volume":"167","author":"M Matsunami","year":"2012","unstructured":"Matsunami M, Miki T, Nishiura K, Hayashi Y, Okawa Y, Nishikawa H, Sekiguchi F, Kubo L, Ozaki T, Tsujiuchi T, Kawabata A (2012) Involvement of the endogenous hydrogen sulfide\/Ca(v) 3.2\u00a0T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. Br J Pharmacol 167:917\u2013928","journal-title":"Br J Pharmacol"},{"key":"5_CR57","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/ijir.2012.39","volume":"25","author":"J Meng","year":"2013","unstructured":"Meng J, Ganesan Adaikan P, Srilatha B (2013) Hydrogen sulfide promotes nitric oxide production in corpus cavernosum by enhancing expression of endothelial nitric oxide synthase. Int J Impot Res 25:86\u201390","journal-title":"Int J Impot Res"},{"key":"5_CR58","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1046\/j.1464-410x.2001.02228.x","volume":"87","author":"I Milsom","year":"2001","unstructured":"Milsom I, Abrams P, Cardozo L, Roberts RG, Thuroff J, Wein AJ (2001) How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int 87:760\u2013766","journal-title":"BJU Int"},{"key":"5_CR59","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S1056-8719(00)00114-3","volume":"44","author":"V Mirone","year":"2000","unstructured":"Mirone V, Sorrentino R, di Villa BR, Imbimbo C, Palmieri A, Fusco F, Tajana G, Cirino G (2000) A standardized procedure for using human corpus cavernosum strips to evaluate drug activity. J Pharmacol Toxicol Methods 44:477\u2013482","journal-title":"J Pharmacol Toxicol Methods"},{"key":"5_CR60","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ceca.2012.07.001","volume":"53","author":"L Munaron","year":"2013","unstructured":"Munaron L, Avanzato D, Moccia F, Mancardi D (2013) Hydrogen sulfide as a regulator of calcium channels. Cell Calcium 53:77\u201384","journal-title":"Cell Calcium"},{"key":"5_CR61","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","volume":"109","author":"AK Mustafa","year":"2011","unstructured":"Mustafa AK, Sikka G, Gazi SK, Steppan J, Jung SM, Bhunia AK, Barodka VM, Gazi FK, Barrow RK, Wang R, Amzel LM, Berkowitz DE, Snyder SH (2011) Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 109:1259\u20131268","journal-title":"Circ Res"},{"key":"5_CR62","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.mayocp.2012.06.015","volume":"87","author":"A Nehra","year":"2012","unstructured":"Nehra A, Jackson G, Miner M, Billups KL, Burnett AL, Buvat J, Carson CC, Cunningham GR, Ganz P, Goldstein I, Guay AT, Hackett G, Kloner RA, Kostis J, Montorsi P, Ramsey M, Rosen R, Sadovsky R, Seftel AD, Shabsigh R, Vlachopoulos C, Wu FC (2012) The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc 87:766\u2013778","journal-title":"Mayo Clin Proc"},{"key":"5_CR63","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/cvr\/cvr137","volume":"91","author":"CP Nelson","year":"2011","unstructured":"Nelson CP, Rainbow RD, Brignell JL, Perry MD, Willets JM, Davies NW, Standen NB, Challiss RA (2011) Principal role of adenylyl cyclase 6 in K+ channel regulation and vasodilator signalling in vascular smooth muscle cells. Cardiovasc Res 91:694\u2013702","journal-title":"Cardiovasc Res"},{"key":"5_CR64","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1152\/physrev.00021.2006","volume":"87","author":"B Nilius","year":"2007","unstructured":"Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165\u2013217","journal-title":"Physiol Rev"},{"issue":"5","key":"5_CR65","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1089\/ars.2014.5930","volume":"22","author":"KR Olson","year":"2014","unstructured":"Olson KR (2014) Hydrogen sulfide as an oxygen sensor. Antioxid Redox Signal 22(5):377\u2013397","journal-title":"Antioxid Redox Signal"},{"key":"5_CR66","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/BF00178975","volume":"342","author":"R Patacchini","year":"1990","unstructured":"Patacchini R, Maggi CA, Meli A (1990) Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents. Naunyn Schmiedebergs Arch Pharmacol 342:72\u201377","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"5_CR67","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/sj.bjp.0705764","volume":"142","author":"R Patacchini","year":"2004","unstructured":"Patacchini R, Santicioli P, Giuliani S, Maggi CA (2004) Hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat urinary bladder. Br J Pharmacol 142:31\u201334","journal-title":"Br J Pharmacol"},{"key":"5_CR68","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejphar.2005.01.005","volume":"509","author":"R Patacchini","year":"2005","unstructured":"Patacchini R, Santicioli P, Giuliani S, Maggi CA (2005) Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle. Eur J Pharmacol 509:171\u2013177","journal-title":"Eur J Pharmacol"},{"key":"5_CR69","doi-asserted-by":"crossref","first-page":"R1427","DOI":"10.1152\/ajpregu.2001.280.5.R1427","volume":"280","author":"GV Petkov","year":"2001","unstructured":"Petkov GV, Heppner TJ, Bonev AD, Herrera GM, Nelson MT (2001) Low levels of KATP channel activation decrease excitability and contractility of urinary bladder. Am J Physiol Regul Integr Comp Physiol 280:R1427\u2013R1433","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"5_CR70","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/(SICI)1096-9136(199810)15:10<821::AID-DIA697>3.0.CO;2-P","volume":"15","author":"DE Price","year":"1998","unstructured":"Price DE, Gingell JC, Gepi-Attee S, Warcham K, Yates P, Boolell M (1998) Sildenafil: study of a novel oral treatment for erectile dysfunction in diabetic men. Diabet Med 15:821\u2013825","journal-title":"Diabet Med"},{"key":"5_CR71","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2164\/jandrol.111.014936","volume":"33","author":"X Qiu","year":"2012","unstructured":"Qiu X, Villalta J, Lin G, Lue TF (2012) Role of hydrogen sulfide in the physiology of penile erection. J Androl 33:529\u2013535","journal-title":"J Androl"},{"key":"5_CR72","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1001\/jama.281.5.421","volume":"281","author":"MS Rendell","year":"1999","unstructured":"Rendell MS, Rajfer J, Wicker PA, Smith MD (1999) Sildenafil for treatment of erectile dysfunction in men with diabetes. A randomized controlled trial. JAMA 281:421\u2013426","journal-title":"JAMA"},{"key":"5_CR73","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.urology.2003.10.071","volume":"63","author":"JL Ruiz Rubio","year":"2004","unstructured":"Ruiz Rubio JL, Hern\u00e1ndez M, Arcos L, Benedito S, Recio P, Garc\u00eda P, Garc\u00eda-Sacrist\u00e1n A, Prieto D (2004) Role of ATP-sensitive K+ channels in relaxation of penile resistance arteries. Urology 63:800\u2013805","journal-title":"Urology"},{"key":"5_CR74","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.2337\/diacare.25.12.2159","volume":"25","author":"I Saenz de Tejada","year":"2002","unstructured":"Saenz de Tejada I, Anglin G, Knight JR, Emmick JT (2002) Effects of tadalafil on erectile dysfunction in men with diabetes. Diabetes Care 25:2159\u20132164","journal-title":"Diabetes Care"},{"key":"5_CR75","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.1161\/CIRCULATIONAHA.108.843979","volume":"120","author":"FN Salloum","year":"2009","unstructured":"Salloum FN, Chau VQ, Hoke NN, Abbate A, Varma A, Ockaili RA, Toldo S, Kukreja RC (2009) Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia\/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide. Circulation 120:S31\u2013S36","journal-title":"Circulation"},{"key":"5_CR76","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s00345-003-0371-y","volume":"21","author":"D Schultheiss","year":"2003","unstructured":"Schultheiss D, Badalyan R, Pilatz A, Gabouev AI, Schlote N, Wefer J, von Wasielewski R, Mertsching H, Sohn M, Stief CG, Jonas U (2003) Androgen and estrogen receptors in the human corpus cavernosum penis: immunohistochemical and cell culture results. World J Urol 21:320\u2013324","journal-title":"World J Urol"},{"key":"5_CR77","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0022-3565(24)38801-9","volume":"296","author":"CC Shieh","year":"2001","unstructured":"Shieh CC, Feng J, Buckner SA, Brioni JD, Coghlan MJ, Sullivan JP, Gopalakrishnan M (2001) Functional implication of spare ATP-sensitive K+ channels in bladder smooth muscle cells. J Pharmacol Exp Ther 296:669\u2013675","journal-title":"J Pharmacol Exp Ther"},{"key":"5_CR78","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1111\/j.1464-410X.2009.08415.x","volume":"103","author":"N Shukla","year":"2009","unstructured":"Shukla N, Rossoni G, Hotston M, Sparatore A, Del Soldato P, Tazzari V, Persad R, Angelini GD, Jeremy JY (2009) Effect of hydrogen sulphide-donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats. BJU Int 103:1522\u20131529","journal-title":"BJU Int"},{"key":"5_CR79","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1016\/S0022-5347(05)65049-5","volume":"167","author":"M Spektor","year":"2002","unstructured":"Spektor M, Rodriguez R, Rosenbaum RS, Wang HZ, Melman A, Christ GJ (2002) Potassium channels and human corporeal smooth muscle cell tone: further evidence of the physiological relevance of the Maxi-K channel subtype to the regulation of human corporeal smooth muscle tone in vitro. J Urol 167:2628\u20132635","journal-title":"J Urol"},{"key":"5_CR80","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.ejphar.2006.02.001","volume":"535","author":"B Srilatha","year":"2006","unstructured":"Srilatha B, Adaikan PG, Moore PK (2006) Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction\u2013a pilot study. Eur J Pharmacol 535:280\u2013282","journal-title":"Eur J Pharmacol"},{"key":"5_CR81","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1111\/j.1743-6109.2007.00561.x","volume":"4","author":"B Srilatha","year":"2007","unstructured":"Srilatha B, Adaikan PG, Li L, Moore PK (2007) Hydrogen sulphide: a novel endogenous gasotransmitter facilitates erectile function. J Sex Med 4:1304\u20131311","journal-title":"J Sex Med"},{"key":"5_CR82","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1111\/j.1743-6109.2009.01291.x","volume":"6","author":"B Srilatha","year":"2009","unstructured":"Srilatha B, Hu L, Adaikan GP, Moore PK (2009) Initial characterization of hydrogen sulfide effects in female sexual function. J Sex Med 6:1875\u20131884","journal-title":"J Sex Med"},{"key":"5_CR83","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3109\/13685538.2012.668722","volume":"15","author":"B Srilatha","year":"2012","unstructured":"Srilatha B, Muthulakshmi P, Adaikan PG, Moore PK (2012) Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats. Aging Male 15:153\u2013158","journal-title":"Aging Male"},{"key":"5_CR84","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","volume":"112","author":"GM Story","year":"2003","unstructured":"Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819\u2013829","journal-title":"Cell"},{"key":"5_CR85","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.eururo.2007.10.024","volume":"53","author":"T Streng","year":"2008","unstructured":"Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, H\u00f6gest\u00e4tt ED, Zygmunt PM (2008) Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol 53:391\u2013399","journal-title":"Eur Urol"},{"key":"5_CR86","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1089\/ars.2012.4805","volume":"19","author":"G Tang","year":"2013","unstructured":"Tang G, Yang G, Jiang B, Ju Y, Wu L, Wang R (2013) H2S is an endothelium-derived hyperpolarizing factor. Antioxid Redox Signal 19:1634\u20131646","journal-title":"Antioxid Redox Signal"},{"key":"5_CR87","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.eururo.2007.02.034","volume":"52","author":"AM Traish","year":"2007","unstructured":"Traish AM, Goldstein I, Kim NN (2007) Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction. Eur Urol 52:54\u201370","journal-title":"Eur Urol"},{"key":"5_CR88","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S0022-5347(05)64920-8","volume":"168","author":"K Venkateswarlu","year":"2002","unstructured":"Venkateswarlu K, Giraldi A, Zhao W, Wang HZ, Melman A, Spektor M, Christ GJ (2002) Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers. J Urol 168:355\u2013361","journal-title":"J Urol"},{"key":"5_CR89","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/sj.ijir.3900910","volume":"14","author":"MA Vickers","year":"2002","unstructured":"Vickers MA, Satyanarayana R (2002) Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. Int J Impot Res 14:466\u2013471","journal-title":"Int J Impot Res"},{"key":"5_CR90","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1089\/152308603768295249","volume":"5","author":"R Wang","year":"2003","unstructured":"Wang R (2003) The gasotransmitter role of hydrogen sulfide. Antioxid Redox Signal 5:493\u2013501","journal-title":"Antioxid Redox Signal"},{"key":"5_CR91","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/ki.2009.221","volume":"76","author":"R Wang","year":"2009","unstructured":"Wang R (2009) Hydrogen sulfide: a new EDRF. Kidney Int 76:700\u2013704","journal-title":"Kidney Int"},{"key":"5_CR92","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ijcard.2014.01.068","volume":"172","author":"S Xu","year":"2014","unstructured":"Xu S, Liu Z, Liu P (2014) Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis. Int J Cardiol 172:313\u2013317","journal-title":"Int J Cardiol"},{"key":"5_CR93","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.2047-2927.2012.00060.x","volume":"1","author":"J Yang","year":"2013","unstructured":"Yang J, Wang T, Yang J, Rao K, Zhan Y, Chen RB, Liu Z, Li MC, Zhuan L, Zang GH, Guo SM, Xu H, Wang SG, Liu JH, Ye ZQ (2013) S-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic rats. Andrology 1:487\u2013494","journal-title":"Andrology"},{"issue":"6","key":"5_CR94","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1111\/bph.12700","volume":"172","author":"G Yetik-Anacak","year":"2014","unstructured":"Yetik-Anacak G, Sorrentino R, Linder AE, Murat N (2014) Gas what: NO is not the only answer to sexual function. Br J Pharmacol 172(6):1434\u20131454","journal-title":"Br J Pharmacol"},{"key":"5_CR95","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.urology.2008.12.022","volume":"74","author":"O Yildiz","year":"2009","unstructured":"Yildiz O, Seyrek M, Irkilata HC, Yildirim I, Tahmaz L, Dayanc M (2009) Testosterone might cause relaxation of human corpus cavernosum by potassium channel opening action. Urology 74:229\u2013232","journal-title":"Urology"},{"key":"5_CR96","doi-asserted-by":"publisher","first-page":"H474","DOI":"10.1152\/ajpheart.00013.2002","volume":"283","author":"W Zhao","year":"2002","unstructured":"Zhao W, Wang R (2002) H2S-induced vasorelaxation and underlying cellular and molecular mechanisms. Am J Physiol Heart Circ Physiol 283:H474\u2013H480","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5_CR97","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","volume":"20","author":"W Zhao","year":"2001","unstructured":"Zhao W, Zhang J, Lu Y, Wang R (2001) The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener. EMBO J 20:6008\u20136016","journal-title":"EMBO J"},{"key":"5_CR98","doi-asserted-by":"publisher","first-page":"20824","DOI":"10.1074\/jbc.M114.559518","volume":"289","author":"K Zhao","year":"2014","unstructured":"Zhao K, Li S, Wu L, Lai C, Yang G (2014) Hydrogen sulfide represses androgen receptor transactivation by targeting at the second zinc finger module. J Biol Chem 289:20824\u201320835","journal-title":"J Biol Chem"},{"key":"5_CR99","first-page":"605","volume":"20","author":"C Zuo","year":"2014","unstructured":"Zuo C, Huang YM, Jiang R, Yang HF, Cheng B, Chen F (2014) Endogenous hydrogen sulfide and androgen deficiency-induced erectile dysfunction in rats. Zhonghua Nan Ke Xue 20:605\u2013612","journal-title":"Zhonghua Nan Ke Xue"}],"container-title":["Handbook of Experimental Pharmacology","Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-18144-8_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T23:49:28Z","timestamp":1748476168000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-319-18144-8_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9783319181431","9783319181448"],"references-count":99,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-18144-8_5","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-3-319-18144-8","asserted-by":"object"}]},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}