{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:58:47Z","timestamp":1787162327733,"version":"build-2736575974"},"publisher-location":"Cham","reference-count":132,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319226705","type":"print"},{"value":"9783319226712","type":"electronic"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-3-319-22671-2_3","type":"book-chapter","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T12:03:54Z","timestamp":1449835434000},"page":"17-39","source":"Crossref","is-referenced-by-count":45,"title":["microRNA and Pain"],"prefix":"10.1007","author":[{"given":"Atsushi","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"3_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nn.3629","volume":"17","author":"SA Prescott","year":"2014","unstructured":"Prescott SA, Ma Q, De Koninck Y. Normal and abnormal coding of somatosensory stimuli causing pain. Nat Neurosci. 2014;17:183\u201391.","journal-title":"Nat Neurosci"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/nm.2231","volume":"16","author":"R Kuner","year":"2010","unstructured":"Kuner R. Central mechanisms of pathological pain. Nat Med. 2010;16:1258\u201366.","journal-title":"Nat Med"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nrn2947","volume":"11","author":"AJ Todd","year":"2010","unstructured":"Todd AJ. Neuronal circuitry for pain processing in the dorsal horn. Nat Rev Neurosci. 2010;11:823\u201336.","journal-title":"Nat Rev Neurosci"},{"key":"3_CR4","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1016\/j.pain.2010.11.010","volume":"152","author":"AV Apkarian","year":"2011","unstructured":"Apkarian AV, Hashmi JA, Baliki MN. Pain and the brain: specificity and plasticity of the brain in clinical chronic pain. Pain. 2011;152:S49\u201364.","journal-title":"Pain"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1016\/j.pain.2013.06.004","volume":"154","author":"RH Dworkin","year":"2013","unstructured":"Dworkin RH, O\u2019Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD. Interventional management of neuropathic pain: NeuPSIG recommendations. Pain. 2013;154:2249\u201361.","journal-title":"Pain"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.tins.2014.04.002","volume":"37","author":"C Luo","year":"2014","unstructured":"Luo C, Kuner T, Kuner R. Synaptic plasticity in pathological pain. Trends Neurosci. 2014;37:343\u201355.","journal-title":"Trends Neurosci"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nn.3602","volume":"17","author":"SG Waxman","year":"2014","unstructured":"Waxman SG, Zamponi GW. Regulating excitability of peripheral afferents: emerging ion channel targets. Nat Neurosci. 2014;17:153\u201363.","journal-title":"Nat Neurosci"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.euroneuro.2011.05.005","volume":"22","author":"FT Nickel","year":"2012","unstructured":"Nickel FT, Seifert F, Lanz S, Maih\u00f6fner C. Mechanisms of neuropathic pain. Eur Neuropsychopharmacol. 2012;22:81\u201391.","journal-title":"Eur Neuropsychopharmacol"},{"issue":"4","key":"3_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.tins.2015.02.001","volume":"38","author":"G Descalzi","year":"2015","unstructured":"Descalzi G, Ikegami D, Ushijima T, Nestler EJ, Zachariou V, Narita M. Epigenetic mechanisms of chronic pain. Trends Neurosci. 2015;38(4):237\u201346.","journal-title":"Trends Neurosci"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","volume":"154","author":"RR Ji","year":"2013","unstructured":"Ji RR, Berta T, Nedergaard M. Glia and pain: is chronic pain a gliopathy? Pain. 2013;154:S10\u201328.","journal-title":"Pain"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0304-3959(03)00301-4","volume":"106","author":"LA McWilliams","year":"2003","unstructured":"McWilliams LA, Cox BJ, Enns MW. Mood and anxiety disorders associated with chronic pain: an examination in a nationally representative sample. Pain. 2003;106:127\u201333.","journal-title":"Pain"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"713","DOI":"10.2147\/JPR.S45958","volume":"6","author":"GC Quintero","year":"2013","unstructured":"Quintero GC. Advances in cortical modulation of pain. J Pain Res. 2013;6:713\u201325.","journal-title":"J Pain Res"},{"key":"3_CR13","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrn3516","volume":"14","author":"MC Bushnell","year":"2013","unstructured":"Bushnell MC, \u010ceko M, Low LA. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci. 2013;14:502\u201311.","journal-title":"Nat Rev Neurosci"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fnmol.2014.00005","volume":"7","author":"P Follert","year":"2014","unstructured":"Follert P, Cremer H, B\u00e9clin C. MicroRNAs in brain development and function: a matter of flexibility and stability. Front Mol Neurosci. 2014;7:5.","journal-title":"Front Mol Neurosci"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.expneurol.2014.08.005","volume":"268","author":"E Sun","year":"2015","unstructured":"Sun E, Shi Y. MicroRNAs: small molecules with big roles in neurodevelopment and diseases. Exp Neurol. 2015;268:46\u201353.","journal-title":"Exp Neurol"},{"key":"3_CR16","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrneurol.2013.67","volume":"9","author":"OG Bhalala","year":"2013","unstructured":"Bhalala OG, Srikanth M, Kessler JA. The emerging roles of microRNAs in CNS injuries. Nat Rev Neurol. 2013;9:328\u201339.","journal-title":"Nat Rev Neurol"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neuint.2014.05.010","volume":"77","author":"A Sakai","year":"2014","unstructured":"Sakai A, Suzuki H. Emerging roles of microRNAs in chronic pain. Neurochem Int. 2014;77:58\u201367.","journal-title":"Neurochem Int"},{"key":"3_CR18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cphy.c110002","volume":"3","author":"Z Wang","year":"2013","unstructured":"Wang Z. miRNA in the regulation of ion channel\/transporter expression. Compr Physiol. 2013;3:599\u2013653.","journal-title":"Compr Physiol"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"10860","DOI":"10.1523\/JNEUROSCI.1980-10.2010","volume":"30","author":"J Zhao","year":"2010","unstructured":"Zhao J, Lee MC, Momin A, Cendan CM, Shepherd ST, Baker MD, Asante C, Bee L, Bethry A, Perkins JR, Nassar MA, Abrahamsen B, Dickenson A, Cobb BS, Merkenschlager M, Wood JN. Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds. J Neurosci. 2010;30:10860\u201371.","journal-title":"J Neurosci"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1097\/ALN.0b013e31826571aa","volume":"117","author":"Y Sun","year":"2012","unstructured":"Sun Y, Li XQ, Sahbaie P, Shi XY, Li WW, Liang DY, Clark JD. miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression. Anesthesiology. 2012;117:626\u201338.","journal-title":"Anesthesiology"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00418-010-0772-0","volume":"135","author":"I Bastian","year":"2011","unstructured":"Bastian I, Tam TS, Zhou XF, Kazenwadel J, Van der Hoek M, Michael MZ, Gibbins I, Haberberger RV. Differential expression of microRNA-1 in dorsal root ganglion neurons. Histochem Cell Biol. 2011;135:37\u201345.","journal-title":"Histochem Cell Biol"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1744-8069-7-17","volume":"7","author":"R Kusuda","year":"2011","unstructured":"Kusuda R, Cadetti F, Ravanelli MI, Sousa TA, Zanon S, De Lucca FL, Lucas G. Differential expression of microRNAs in mouse pain models. Mol Pain. 2011;7:17.","journal-title":"Mol Pain"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1002\/emmm.201302797","volume":"5","author":"KK Bali","year":"2013","unstructured":"Bali KK, Selvaraj D, Satagopam VP, Lu J, Schneider R, Kuner R. Genome-wide identification and functional analyses of microRNA signatures associated with cancer pain. EMBO Mol Med. 2013;5:1740\u201358.","journal-title":"EMBO Mol Med"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.pneurobio.2008.04.004","volume":"85","author":"A Merighi","year":"2008","unstructured":"Merighi A, Salio C, Ghirri A, Lossi L, Ferrini F, Betelli C, Bardoni R. BDNF as a pain modulator. Prog Neurobiol. 2008;85:297\u2013317.","journal-title":"Prog Neurobiol"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0304-3940(02)00078-2","volume":"322","author":"A Galan","year":"2002","unstructured":"Galan A, Lopez-Garcia JA, Cervero F, Laird JMA. Activation of spinal extracellular signaling-regulated kinase-1 and -2 by intraplantar carrageenan in rodents. Neurosci Lett. 2002;322:37\u201340.","journal-title":"Neurosci Lett"},{"key":"3_CR26","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.pain.2009.04.013","volume":"144","author":"S Staaf","year":"2009","unstructured":"Staaf S, Oerther S, Lucas G, Mattsson JP, Ernfors P. Differential regulation of TRP channels in a rat model of neuropathic pain. Pain. 2009;144:187\u201399.","journal-title":"Pain"},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.pain.2012.11.010","volume":"154","author":"KL Kynast","year":"2013","unstructured":"Kynast KL, Russe OQ, M\u00f6ser CV, Geisslinger G, Niederberger E. Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice. Pain. 2013;154:368\u201376.","journal-title":"Pain"},{"key":"3_CR28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1744-8069-4-35","volume":"4","author":"SM G\u00e9ranton","year":"2008","unstructured":"G\u00e9ranton SM, Fratto V, Tochiki KK, Hunt SP. Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn. Mol Pain. 2008;4:35.","journal-title":"Mol Pain"},{"key":"3_CR29","doi-asserted-by":"publisher","first-page":"6163","DOI":"10.1523\/JNEUROSCI.1306-07.2007","volume":"27","author":"SM G\u00e9ranton","year":"2007","unstructured":"G\u00e9ranton SM, Morenilla-Palao C, Hunt SP. A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. J Neurosci. 2007;27:6163\u201373.","journal-title":"J Neurosci"},{"key":"3_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/1742-2094-9-143","volume":"9","author":"HL Willemen","year":"2012","unstructured":"Willemen HL, Huo XJ, Mao-Ying QL, Zijlstra J, Heijnen CJ, Kavelaars A. MicroRNA-124 as a novel treatment for persistent hyperalgesia. J Neuroinflammation. 2012;9:143.","journal-title":"J Neuroinflammation"},{"key":"3_CR31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neuron.2014.02.011","volume":"82","author":"CK Park","year":"2014","unstructured":"Park CK, Xu ZZ, Berta T, Han Q, Chen G, Liu XJ, Ji RR. Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. Neuron. 2014;82:47\u201354.","journal-title":"Neuron"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","volume":"140","author":"O Takeuchi","year":"2010","unstructured":"Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140:805\u201320.","journal-title":"Cell"},{"key":"3_CR33","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.jpain.2005.09.006","volume":"7","author":"M Devor","year":"2006","unstructured":"Devor M. Sodium channels and mechanisms of neuropathic pain. J Pain. 2006;7:S3\u201312.","journal-title":"J Pain"},{"key":"3_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023423","volume":"6","author":"IT Strickland","year":"2011","unstructured":"Strickland IT, Richards L, Holmes FE, Wynick D, Uney JB, Wong LF. Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons. PLoS One. 2011;6, e23423.","journal-title":"PLoS One"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/abbs\/gmr083","volume":"43","author":"B Yu","year":"2011","unstructured":"Yu B, Zhou S, Qian T, Wang Y, Ding F, Gu X. Altered microRNA expression following sciatic nerve resection in dorsal root ganglia of rats. Acta Biochim Biophys Sin (Shanghai). 2011;43:909\u201315.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"3_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024612","volume":"6","author":"B Yu","year":"2011","unstructured":"Yu B, Zhou S, Wang Y, Ding G, Ding F, Gu X. Profile of microRNAs following rat sciatic nerve injury by deep sequencing: implication for mechanisms of nerve regeneration. PLoS One. 2011;6, e24612.","journal-title":"PLoS One"},{"key":"3_CR37","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.brainres.2011.01.067","volume":"1383","author":"HY Zhang","year":"2011","unstructured":"Zhang HY, Zheng SJ, Zhao JH, Zhao W, Zheng LF, Zhao D, Li JM, Zhang XF, Chen ZB, Yi XN. MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection. Brain Res. 2011;1383:62\u201370.","journal-title":"Brain Res"},{"key":"3_CR38","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neulet.2011.02.064","volume":"494","author":"S Zhou","year":"2011","unstructured":"Zhou S, Yu B, Qian T, Yao D, Wang Y, Ding F, Gu X. Early changes of microRNAs expression in the dorsal root ganglia following rat sciatic nerve transection. Neurosci Lett. 2011;494:89\u201393.","journal-title":"Neurosci Lett"},{"key":"3_CR39","doi-asserted-by":"publisher","first-page":"e44768","DOI":"10.1371\/journal.pone.0044768","volume":"7","author":"S Zhou","year":"2012","unstructured":"Zhou S, Shen D, Wang Y, Gong L, Tang X, Yu B, Gu X, Ding F. microRNA-222 targeting PTEN promotes neurite outgrowth from adult dorsal root ganglion neurons following sciatic nerve transection. PLoS One. 2012;7:e44768.","journal-title":"PLoS One"},{"key":"3_CR40","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/1471-2474-11-181","volume":"11","author":"CS Rau","year":"2010","unstructured":"Rau CS, Jeng JC, Jeng SF, Lu TH, Chen YC, Liliang PC, Wu CJ, Lin CJ, Hsieh CH. Entrapment neuropathy results in different microRNA expression patterns from denervation injury in rats. BMC Musculoskelet Disord. 2010;11:181.","journal-title":"BMC Musculoskelet Disord"},{"key":"3_CR41","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.4103\/1673-5374.133164","volume":"9","author":"A Lu","year":"2014","unstructured":"Lu A, Huang Z, Zhang C, Zhang X, Zhao J, Zhang H, Zhang Q, Wu S, Yi X. Differential expression of microRNAs in dorsal root ganglia after sciatic nerve injury. Neural Regen Res. 2014;9:1031\u201340.","journal-title":"Neural Regen Res"},{"key":"3_CR42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3892\/ijmm.2013.1381","volume":"32","author":"H Li","year":"2013","unstructured":"Li H, Shen L, Ma C, Huang Y. Differential expression of miRNAs in the nervous system of a rat model of bilateral sciatic nerve chronic constriction injury. Int J Mol Med. 2013;32:219\u201326.","journal-title":"Int J Mol Med"},{"key":"3_CR43","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fnmol.2013.00035","volume":"6","author":"D Wu","year":"2013","unstructured":"Wu D, Murashov AK. MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist Kremen1. Front Mol Neurosci. 2013;6:35.","journal-title":"Front Mol Neurosci"},{"key":"3_CR44","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3389\/fnins.2014.00266","volume":"8","author":"M Norcini","year":"2014","unstructured":"Norcini M, Sideris A, Martin Hernandez LA, Zhang J, Blanck TJJ, Recio-Pinto E. An approach to identify microRNAs involved in neuropathic pain following a peripheral nerve injury. Front Neurosci. 2014;8:266.","journal-title":"Front Neurosci"},{"key":"3_CR45","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1093\/brain\/awt191","volume":"136","author":"A Sakai","year":"2013","unstructured":"Sakai A, Saitow F, Miyake N, Miyake K, Shimada T, Suzuki H. miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability. Brain. 2013;136:2738\u201350.","journal-title":"Brain"},{"key":"3_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017670","volume":"6","author":"D von Schack","year":"2011","unstructured":"von Schack D, Agostino MJ, Murray BS, Li Y, Reddy PS, Chen J, Choe SE, Strassle BW, Li C, Bates B, Zhang L, Hu H, Kotnis S, Bingham B, Liu W, Whiteside GT, Samad TA, Kennedy JD, Ajit SK. Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain. PLoS One. 2011;6, e17670.","journal-title":"PLoS One"},{"key":"3_CR47","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1744-8069-10-22","volume":"10","author":"KK Bali","year":"2014","unstructured":"Bali KK, Hackenberg M, Lubin A, Kuner R, Devor M. Sources of individual variability: miRNAs that predispose to neuropathic pain identified using genome-wide sequencing. Mol Pain. 2014;10:22.","journal-title":"Mol Pain"},{"key":"3_CR48","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.neuroscience.2011.06.017","volume":"190","author":"D Wu","year":"2011","unstructured":"Wu D, Raafat M, Pak E, Hammond S, Murashov AK. MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern. Neuroscience. 2011;190:386\u201397.","journal-title":"Neuroscience"},{"key":"3_CR49","doi-asserted-by":"publisher","first-page":"17358","DOI":"10.1523\/JNEUROSCI.3931-11.2011","volume":"31","author":"A Viader","year":"2011","unstructured":"Viader A, Chang LW, Fahrner T, Nagarajan R, Milbrandt J. MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes. J Neurosci. 2011;31:17358\u201369.","journal-title":"J Neurosci"},{"key":"3_CR50","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1093\/abbs\/gmu090","volume":"46","author":"Y Xu","year":"2014","unstructured":"Xu Y, Zhang X, Pu S, Wu J, Lv Y, Du D. Circulating microRNA expression profile: a novel potential predictor for chronic nervous lesions. Acta Biochim Biophys Sin (Shanghai). 2014;46:942\u20139.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"3_CR51","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fgene.2013.00020","volume":"4","author":"RPR Metpally","year":"2013","unstructured":"Metpally RPR, Nasser S, Malenica I, Courtright A, Carlson E, Ghaffari L, Villa S, Tembe W, Van Keuren-Jensen K. Comparison of analysis tools for miRNA high throughput sequencing using nerve crush as a model. Front Genet. 2013;4:20.","journal-title":"Front Genet"},{"key":"3_CR52","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.expneurol.2011.11.041","volume":"233","author":"D Wu","year":"2012","unstructured":"Wu D, Raafat A, Pak E, Clemens S, Murashov AK. Dicer-microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro. Exp Neurol. 2012;233:555\u201365.","journal-title":"Exp Neurol"},{"key":"3_CR53","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/0092-8674(95)90121-3","volume":"83","author":"LL Isom","year":"1995","unstructured":"Isom LL, Ragsdale DS, De Jongh KS, Westenbroek RE, Reber BFX, Scheuer T, Catterall WA. Structure and function of the \u03b22 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 1995;83:433\u201342.","journal-title":"Cell"},{"key":"3_CR54","doi-asserted-by":"publisher","first-page":"7984","DOI":"10.1523\/JNEUROSCI.2211-06.2006","volume":"26","author":"LF Lopez-Santiago","year":"2006","unstructured":"Lopez-Santiago LF, Pertin M, Morisod X, Chen C, Hong S, Wiley J, Decosterd I, Isom LL. Sodium channel \u03b22 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J Neurosci. 2006;26:7984\u201394.","journal-title":"J Neurosci"},{"key":"3_CR55","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.neuroscience.2009.08.033","volume":"164","author":"BT Aldrich","year":"2009","unstructured":"Aldrich BT, Frakes EP, Kasuya J, Hammond DL, Kitamoto T. Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Neuroscience. 2009;164:711\u201323.","journal-title":"Neuroscience"},{"key":"3_CR56","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s11064-013-1192-z","volume":"39","author":"HP Chen","year":"2014","unstructured":"Chen HP, Zhou W, Kang LM, Yan H, Zhang L, Xu BH, Cai WH. Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury. Neurochem Res. 2014;39:76\u201383.","journal-title":"Neurochem Res"},{"key":"3_CR57","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1111\/ejn.12522","volume":"39","author":"CR Lin","year":"2014","unstructured":"Lin CR, Chen KH, Yang CH, Huang HW, Sheen-Chen SM. Intrathecal miR-183 delivery suppresses mechanical allodynia in mononeuropathic rats. Eur J Neurosci. 2014;39:1682\u20139.","journal-title":"Eur J Neurosci"},{"key":"3_CR58","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1042\/BST0370918","volume":"37","author":"SD Selcuklu","year":"2009","unstructured":"Selcuklu SD, Donoghue MTA, Spillane C. miR-21 as a key regulator of oncogenic processes. Biochem Soc Trans. 2009;37:918\u201325.","journal-title":"Biochem Soc Trans"},{"key":"3_CR59","doi-asserted-by":"publisher","first-page":"706","DOI":"10.4161\/rna.8.5.16154","volume":"8","author":"R Kumarswamy","year":"2011","unstructured":"Kumarswamy R, Volkmann I, Thum T. Regulation and function of miRNA-21 in health and disease. RNA Biol. 2011;8:706\u201313.","journal-title":"RNA Biol"},{"key":"3_CR60","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.bbrc.2013.04.089","volume":"435","author":"A Sakai","year":"2013","unstructured":"Sakai A, Suzuki H. Nerve injury-induced upregulation of miR-21 in the primary sensory neurons contributes to neuropathic pain in rats. Biochem Biophys Res Commun. 2013;435:176\u201381.","journal-title":"Biochem Biophys Res Commun"},{"key":"3_CR61","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neulet.2014.12.006","volume":"586","author":"S Zhou","year":"2015","unstructured":"Zhou S, Zhang S, Wang Y, Yi S, Zhao L, Tang X, Yu B, Gu X, Ding F. miR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury. Neurosci Lett. 2015;586:43\u20139.","journal-title":"Neurosci Lett"},{"key":"3_CR62","doi-asserted-by":"publisher","first-page":"45131","DOI":"10.1074\/jbc.M111.274076","volume":"286","author":"S Mullenbrock","year":"2011","unstructured":"Mullenbrock S, Shah J, Cooper GM. Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase\/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation. J Biol Chem. 2011;286:45131\u201345.","journal-title":"J Biol Chem"},{"key":"3_CR63","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3892\/ijmm.2012.1163","volume":"31","author":"Y Genda","year":"2013","unstructured":"Genda Y, Arai M, Ishikawa M, Tanaka S, Okabe T, Sakamoto A. microRNA changes in the dorsal horn of the spinal cord of rats with chronic constriction injury: A TaqMan\u00ae Low Density Array study. Int J Mol Med. 2013;31:129\u201337.","journal-title":"Int J Mol Med"},{"key":"3_CR64","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.neulet.2011.11.023","volume":"506","author":"T Brandenburger","year":"2012","unstructured":"Brandenburger T, Castoldi M, Brendel M, Grievink H, Schl\u00f6sser L, Werdehausen R, Bauer I, Hermanns H. Expression of spinal cord microRNAs in a rat model of chronic neuropathic pain. Neurosci Lett. 2012;506:281\u20136.","journal-title":"Neurosci Lett"},{"key":"3_CR65","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.bbrc.2014.12.004","volume":"456","author":"Q Gong","year":"2015","unstructured":"Gong Q, Lu Z, Huang Q, Ruan L, Chen J, Liang Y, Wang H, Yue Y, Feng S. Altered microRNAs expression profiling in mice with diabetic neuropathic pain. Biochem Biophys Res Commun. 2015;456:615\u201320.","journal-title":"Biochem Biophys Res Commun"},{"key":"3_CR66","doi-asserted-by":"publisher","first-page":"3830","DOI":"10.1038\/emboj.2011.249","volume":"30","author":"A Favereaux","year":"2011","unstructured":"Favereaux A, Thoumine O, Bouali-Benazzouz R, Roques V, Papon MA, Salam SA, Drutel G, Leger C, Calas A, Nagy F, Landry M. Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain. EMBO J. 2011;30:3830\u201341.","journal-title":"EMBO J"},{"key":"3_CR67","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1523\/JNEUROSCI.3145-09.2010","volume":"30","author":"P Fossat","year":"2010","unstructured":"Fossat P, Dobremez E, Bouali-Benazzouz R, Favereaux A, Bertrand SS, Kilk K, L\u00e9ger C, Cazalets JR, Langel \u00dc, Landry M, Nagy F. Knockdown of L calcium channel subtypes: differential effects in neuropathic pain. J Neurosci. 2010;30:1073\u201385.","journal-title":"J Neurosci"},{"key":"3_CR68","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/imr.12057","volume":"253","author":"E Vigorito","year":"2013","unstructured":"Vigorito E, Kohlhaas S, Lu D, Leyland R. miR-155: an ancient regulator of the immune system. Immunol Rev. 2013;253:146\u201357.","journal-title":"Immunol Rev"},{"key":"3_CR69","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1007\/s11064-014-1500-2","volume":"40","author":"Y Tan","year":"2014","unstructured":"Tan Y, Yang J, Xiang K, Tan Q, Guo Q. Suppression of MicroRNA-155 attenuates neuropathic pain by regulating SOCS1 signalling pathway. Neurochem Res. 2014;40:550\u201360.","journal-title":"Neurochem Res"},{"key":"3_CR70","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1002\/jbmr.2002","volume":"28","author":"X Li","year":"2013","unstructured":"Li X, Kroin JS, Kc R, Gibson G, Chen D, Corbett GT, Pahan K, Fayyaz S, Kim JS, van Wijnen AJ, Suh J, Kim SG, Im HJ. Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints. J Bone Miner Res. 2013;28:2512\u201322.","journal-title":"J Bone Miner Res"},{"key":"3_CR71","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.intimp.2013.11.001","volume":"18","author":"DS Arroyo","year":"2014","unstructured":"Arroyo DS, Gaviglio EA, Peralta Ramos JM, Bussi C, Rodriguez-Galan MC, Iribarren P. Autophagy in inflammation, infection, neurodegeneration and cancer. Int Immunopharmacol. 2014;18:55\u201365.","journal-title":"Int Immunopharmacol"},{"key":"3_CR72","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1744-8069-11-3","volume":"11","author":"L Berliocchi","year":"2015","unstructured":"Berliocchi L, Maiar\u00f9 M, Varano GP, Russo R, Corasaniti MT, Bagetta G, Tassorelli C. Spinal autophagy is differently modulated in distinct mouse models of neuropathic pain. Mol Pain. 2015;11:3.","journal-title":"Mol Pain"},{"key":"3_CR73","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/glia.22451","volume":"61","author":"G Shi","year":"2013","unstructured":"Shi G, Shi J, Liu K, Liu N, Wang Y, Fu Z, Ding J, Jia L, Yuan W. Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury. Glia. 2013;61:504\u201312.","journal-title":"Glia"},{"key":"3_CR74","doi-asserted-by":"publisher","first-page":"713435","DOI":"10.1155\/2011\/713435","volume":"2011","author":"K Obara","year":"2011","unstructured":"Obara K, Ohsumi Y. Atg14: a key player in orchestrating autophagy. Int J Cell Biol. 2011;2011:713435.","journal-title":"Int J Cell Biol"},{"key":"3_CR75","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/AJP.0000000000000070","volume":"31","author":"H Li","year":"2015","unstructured":"Li H, Huang Y, Ma C, Yu X, Zhang Z, Shen L. MiR-203 involves in neuropathic pain development and represses Rap1a expression in nerve growth factor differentiated neuronal PC12 cells. Clin J Pain. 2015;31:36\u201343.","journal-title":"Clin J Pain"},{"key":"3_CR76","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1177\/1073858410365562","volume":"17","author":"RL Stornetta","year":"2011","unstructured":"Stornetta RL, Zhu JJ. Ras and Rap signaling in synaptic plasticity and mental disorders. Neuroscientist. 2011;17:54\u201378.","journal-title":"Neuroscientist"},{"key":"3_CR77","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0169-328X(97)00024-7","volume":"45","author":"O Urayama","year":"1997","unstructured":"Urayama O, Murakoshi T, Kubota M, Hara Y, Chihara J, Ikawa Y. Coincident induction of K rev-1\/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation. Brain Res Mol Brain Res. 1997;45:331\u20134.","journal-title":"Brain Res Mol Brain Res"},{"key":"3_CR78","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.expneurol.2009.06.015","volume":"219","author":"NK Liu","year":"2009","unstructured":"Liu NK, Wang XF, Lu QB, Xu XM. Altered microRNA expression following traumatic spinal cord injury. Exp Neurol. 2009;219:424\u20139.","journal-title":"Exp Neurol"},{"key":"3_CR79","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/sc.2009.89","volume":"48","author":"K Nakanishi","year":"2010","unstructured":"Nakanishi K, Nakasa T, Tanaka N, Ishikawa M, Yamada K, Yamasaki K, Kamei N, Izumi B, Adachi N, Miyaki S, Asahara H, Ochi M. Responses of microRNAs 124a and 223 following spinal cord injury in mice. Spinal Cord. 2010;48:192\u20136.","journal-title":"Spinal Cord"},{"key":"3_CR80","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.neuroscience.2011.03.063","volume":"186","author":"ER Strickland","year":"2011","unstructured":"Strickland ER, Hook MA, Balaraman S, Huie JR, Grau JW, Miranda RC. MicroRNA dysregulation following spinal cord contusion: implications for neural plasticity and repair. Neuroscience. 2011;186:146\u201360.","journal-title":"Neuroscience"},{"key":"3_CR81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034534","volume":"7","author":"M Yunta","year":"2012","unstructured":"Yunta M, Nieto-D\u00edaz M, Esteban FJ, Caballero-Lopez M, Navarro-Ru\u00edz R, Reigada D, Pita-Thomas DW, del \u00c1guila \u00c1, Mu\u00f1oz-Galdeano T, Maza RM. MicroRNA dysregulation in the spinal cord following traumatic injury. PLoS One. 2012;7, e34534.","journal-title":"PLoS One"},{"key":"3_CR82","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1089\/neu.2012.2748","volume":"30","author":"JZ Hu","year":"2013","unstructured":"Hu JZ, Huang JH, Zeng L, Wang G, Cao M, Lu HB. Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats. J Neurotrauma. 2013;30:1349\u201360.","journal-title":"J Neurotrauma"},{"key":"3_CR83","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fncel.2014.00053","volume":"8","author":"M Nieto-Diaz","year":"2014","unstructured":"Nieto-Diaz M, Esteban FJ, Reigada D, Mu\u00f1oz-Galdeano T, Yunta M, Caballero-L\u00f3pez M, Navarro-Ruiz R, del \u00c1guila \u00c1, Maza RM. MicroRNA dysregulation in spinal cord injury: causes, consequences, and therapeutics. Front Cell Neurosci. 2014;8:53.","journal-title":"Front Cell Neurosci"},{"key":"3_CR84","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neuint.2014.05.005","volume":"77","author":"ER Strickland","year":"2014","unstructured":"Strickland ER, Woller SA, Hook MA, Grau JW, Miranda RC. The association between spinal cord trauma-sensitive miRNAs and pain sensitivity, and their regulation by morphine. Neurochem Int. 2014;77:40\u20139.","journal-title":"Neurochem Int"},{"key":"3_CR85","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fncir.2014.00117","volume":"8","author":"ER Strickland","year":"2014","unstructured":"Strickland ER, Woller SA, Garraway SM, Hook MA, Grau JW, Miranda RC. Regulatory effects of intermittent noxious stimulation on spinal cord injury-sensitive microRNAs and their presumptive targets following spinal cord contusion. Front Neural Circuits. 2014;8:117.","journal-title":"Front Neural Circuits"},{"key":"3_CR86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111594","volume":"9","author":"Y Dong","year":"2014","unstructured":"Dong Y, Li P, Ni Y, Zhao J, Liu Z. Decreased microRNA-125a-3p contributes to upregulation of p38 MAPK in rat trigeminal ganglions with orofacial inflammatory pain. PLoS One. 2014;9, e111594.","journal-title":"PLoS One"},{"key":"3_CR87","doi-asserted-by":"publisher","first-page":"9476","DOI":"10.1523\/JNEUROSCI.5346-13.2014","volume":"34","author":"Z Pan","year":"2014","unstructured":"Pan Z, Zhu LJ, Li YQ, Hao LY, Yin C, Yang JX, Guo Y, Zhang S, Hua L, Xue ZY, Zhang H, Cao JL. Epigenetic modification of spinal miR-219 expression regulates chronic inflammation pain by targeting CaMKII\u03b3. J Neurosci. 2014;34:9476\u201383.","journal-title":"J Neurosci"},{"key":"3_CR88","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3892\/ijmm.2013.1504","volume":"32","author":"Y Hori","year":"2013","unstructured":"Hori Y, Goto G, Arai-Iwasaki M, Ishikawa M, Sakamoto A. Differential expression of rat hippocampal microRNAs in two rat models of chronic pain. Int J Mol Med. 2013;32:1287\u201392.","journal-title":"Int J Mol Med"},{"key":"3_CR89","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nm.2266","volume":"17","author":"ED Ponomarev","year":"2011","unstructured":"Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C\/EBP-\u03b1-PU.1 pathway. Nat Med. 2011;17:64\u201370.","journal-title":"Nat Med"},{"key":"3_CR90","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1744-8069-3-15","volume":"3","author":"G Bai","year":"2007","unstructured":"Bai G, Ambalavanar R, Wei D, Dessem D. Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain. Mol Pain. 2007;3:15.","journal-title":"Mol Pain"},{"key":"3_CR91","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/j.1532-2149.2012.00197.x","volume":"17","author":"J Ni","year":"2013","unstructured":"Ni J, Gao Y, Gong S, Guo S, Hisamitsu T, Jiang X. Regulation of \u03bc-opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation. Eur J Pain. 2013;17:313\u201323.","journal-title":"Eur J Pain"},{"key":"3_CR92","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2174\/1871527314666150116123932","volume":"14","author":"M Barbierato","year":"2015","unstructured":"Barbierato M, Zusso M, Skaper SD, Giusti P. MicroRNAs: emerging role in the endogenous \u03bc opioid system. CNS Neurol Disord Drug Targets. 2015;14:239\u201350.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"3_CR93","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","volume":"36","author":"RR Ji","year":"2002","unstructured":"Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron. 2002;36:57\u201368.","journal-title":"Neuron"},{"key":"3_CR94","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/BOR.0b013e32835d8385","volume":"25","author":"M Ammari","year":"2013","unstructured":"Ammari M, Jorgensen C, Apparailly F. Impact of microRNAs on the understanding and treatment of rheumatoid arthritis. Curr Opin Rheumatol. 2013;25:225\u201333.","journal-title":"Curr Opin Rheumatol"},{"key":"3_CR95","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s11926-013-0353-z","volume":"15","author":"MJ Barter","year":"2013","unstructured":"Barter MJ, Young DA. Epigenetic mechanisms and non-coding RNAs in osteoarthritis. Curr Rheumatol Rep. 2013;15:353.","journal-title":"Curr Rheumatol Rep"},{"key":"3_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2014.12.013","volume":"157","author":"A Picascia","year":"2015","unstructured":"Picascia A, Grimaldi V, Pignalosa O, De Pascale MR, Schiano C, Napoli C. Epigenetic control of autoimmune diseases: from bench to bedside. Clin Immunol. 2015;157:1\u201315.","journal-title":"Clin Immunol"},{"key":"3_CR97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/147323001103900101","volume":"39","author":"C Yu","year":"2011","unstructured":"Yu C, Chen WP, Wang XH. MicroRNA in osteoarthritis. J Int Med Res. 2011;39:1\u20139.","journal-title":"J Int Med Res"},{"key":"3_CR98","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.neuroscience.2013.11.057","volume":"259","author":"L Wang","year":"2014","unstructured":"Wang L, Chopp M, Szalad A, Zhang Y, Wang X, Zhang RL, Liu XS, Jia L, Zhang ZG. The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy. Neuroscience. 2014;259:155\u201363.","journal-title":"Neuroscience"},{"key":"3_CR99","doi-asserted-by":"publisher","first-page":"ii90","DOI":"10.1136\/annrheumdis-2012-202203","volume":"72","author":"EKL Chan","year":"2013","unstructured":"Chan EKL, Ceribelli A, Satoh M. MicroRNA-146a in autoimmunity and innate immune responses. Ann Rheum Dis. 2013;72:ii90\u20135.","journal-title":"Ann Rheum Dis"},{"key":"3_CR100","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/imr.12042","volume":"253","author":"S Montagner","year":"2013","unstructured":"Montagner S, Orlandi EM, Merante S, Monticelli S. The role of miRNAs in mast cells and other innate immune cells. Immunol Rev. 2013;253:12\u201324.","journal-title":"Immunol Rev"},{"key":"3_CR101","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.joca.2008.09.012","volume":"17","author":"SW Jones","year":"2009","unstructured":"Jones SW, Watkins G, Le Good N, Roberts S, Murphy CL, Brockbank SMV, Needham MRC, Read SJ, Newham P. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-\u03b1 and MMP13. Osteoarthritis Cartilage. 2009;17:464\u201372.","journal-title":"Osteoarthritis Cartilage"},{"key":"3_CR102","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1002\/art.24404","volume":"60","author":"K Yamasaki","year":"2009","unstructured":"Yamasaki K, Nakasa T, Miyaki S, Ishikawa M, Deie M, Adachi N, Yasunaga Y, Asahara H, Ochi M. Expression of microRNA-146a in osteoarthritis cartilage. Arthritis Rheum. 2009;60:1035\u201341.","journal-title":"Arthritis Rheum"},{"key":"3_CR103","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s00296-014-3001-7","volume":"34","author":"S Singh","year":"2014","unstructured":"Singh S, Rai G, Aggarwal A. Association of microRNA-146a and its target gene IRAK1 polymorphism with enthesitis related arthritis category of juvenile idiopathic arthritis. Rheumatol Int. 2014;34:1395\u2013400.","journal-title":"Rheumatol Int"},{"key":"3_CR104","doi-asserted-by":"crossref","unstructured":"Zhou Q, Yang L, Larson S, Basra S, Merwat S, Tan A, Croce C, Verne GN. Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1. Gut. 2015, in press.","DOI":"10.1136\/gutjnl-2013-306464"},{"key":"3_CR105","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.yexmp.2014.04.009","volume":"96","author":"NH Fourie","year":"2014","unstructured":"Fourie NH, Peace RM, Abey SK, Sherwin LB, Rahim-Williams B, Smyser PA, Wiley JW, Henderson WA. Elevated circulating miR-150 and miR-342-3p in patients with irritable bowel syndrome. Exp Mol Pathol. 2014;96:422\u20135.","journal-title":"Exp Mol Pathol"},{"key":"3_CR106","doi-asserted-by":"publisher","first-page":"288","DOI":"10.2353\/ajpath.2010.090552","volume":"176","author":"V Sanchez Freire","year":"2010","unstructured":"Sanchez Freire V, Burkhard FC, Kessler TM, Kuhn A, Draeger A, Monastyrskaya K. MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome. Am J Pathol. 2010;176:288\u2013303.","journal-title":"Am J Pathol"},{"key":"3_CR107","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1007\/s00018-013-1275-7","volume":"70","author":"AH Gheinani","year":"2013","unstructured":"Gheinani AH, Burkhard FC, Monastyrskaya K. Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome. Cell Mol Life Sci. 2013;70:3773\u201389.","journal-title":"Cell Mol Life Sci"},{"key":"3_CR108","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.ajpath.2012.10.020","volume":"182","author":"K Monastyrskaya","year":"2013","unstructured":"Monastyrskaya K, S\u00e1nchez-Freire V, Hashemi GA, Klumpp DJ, Babiychuk EB, Draeger A, Burkhard FC. miR-199a-5p regulates urothelial permeability and may play a role in bladder pain syndrome. Am J Pathol. 2013;182:431\u201348.","journal-title":"Am J Pathol"},{"key":"3_CR109","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1136\/gut.2009.181834","volume":"59","author":"Q Zhou","year":"2010","unstructured":"Zhou Q, Souba WW, Croce CM, Verne GN. MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Gut. 2010;59:775\u201384.","journal-title":"Gut"},{"key":"3_CR110","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.pain.2012.09.002","volume":"154","author":"JN Sengupta","year":"2013","unstructured":"Sengupta JN, Pochiraju S, Kannampalli P, Bruckert M, Addya S, Yadav P, Miranda A, Shaker R, Banerjee B. MicroRNA-mediated GABAA\u03b1\u22121 receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats. Pain. 2013;154:59\u201370.","journal-title":"Pain"},{"key":"3_CR111","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3389\/fncel.2014.00143","volume":"8","author":"RE Guzman","year":"2014","unstructured":"Guzman RE, Alekov AK, Filippov M, Hegermann J, Fahlke C. Involvement of ClC-3 chloride\/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons. Front Cell Neurosci. 2014;8:143.","journal-title":"Front Cell Neurosci"},{"key":"3_CR112","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/1479-5876-9-195","volume":"9","author":"IA Orlova","year":"2011","unstructured":"Orlova IA, Alexander GM, Qureshi RA, Sacan A, Graziano A, Barrett JE, Schwartzman RJ, Ajit SK. MicroRNA modulation in complex regional pain syndrome. J Transl Med. 2011;9:195.","journal-title":"J Transl Med"},{"issue":"4","key":"3_CR113","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00296-014-3139-3","volume":"35","author":"JL Bjersing","year":"2014","unstructured":"Bjersing JL, Bokarewa MI, Mannerkorpi K. Profile of circulating microRNAs in fibromyalgia and their relation to symptom severity: an exploratory study. Rheumatol Int. 2014;35(4):635\u201342.","journal-title":"Rheumatol Int"},{"key":"3_CR114","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078762","volume":"8","author":"JL Bjersing","year":"2013","unstructured":"Bjersing JL, Lundborg C, Bokarewa MI, Mannerkorpi K. Profile of cerebrospinal microRNAs in fibromyalgia. PLoS One. 2013;8, e78762.","journal-title":"PLoS One"},{"key":"3_CR115","doi-asserted-by":"crossref","unstructured":"Andersen HH, Duroux M, Gazerani P. Serum microRNA signatures in migraineurs during attacks and in pain-free periods. Mol Neurobiol. 2015, in press.","DOI":"10.1007\/s12035-015-9106-5"},{"key":"3_CR116","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.neuron.2007.07.012","volume":"55","author":"I Tracey","year":"2007","unstructured":"Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron. 2007;55:377\u201391.","journal-title":"Neuron"},{"key":"3_CR117","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tins.2012.06.002","volume":"35","author":"CY Saab","year":"2012","unstructured":"Saab CY. Pain-related changes in the brain: diagnostic and therapeutic potentials. Trends Neurosci. 2012;35:629\u201337.","journal-title":"Trends Neurosci"},{"key":"3_CR118","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neuron.2010.03.002","volume":"66","author":"MN Baliki","year":"2010","unstructured":"Baliki MN, Geha PY, Fields HL, Apkarian AV. Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain. Neuron. 2010;66:149\u201360.","journal-title":"Neuron"},{"key":"3_CR119","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/nn.3811","volume":"17","author":"E Navratilova","year":"2014","unstructured":"Navratilova E, Porreca F. Reward and motivation in pain and pain relief. Nat Neurosci. 2014;17:1304\u201312.","journal-title":"Nat Neurosci"},{"key":"3_CR120","doi-asserted-by":"publisher","first-page":"15294","DOI":"10.1523\/JNEUROSCI.0921-11.2011","volume":"31","author":"S Imai","year":"2011","unstructured":"Imai S, Saeki M, Yanase M, Horiuchi H, Abe M, Narita M, Kuzumaki N, Suzuki T, Narita M. Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain. J Neurosci. 2011;31:15294\u20139.","journal-title":"J Neurosci"},{"key":"3_CR121","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1111\/pme.12066","volume":"14","author":"M Arai","year":"2013","unstructured":"Arai M, Genda Y, Ishikawa M, Shunsuke T, Okabe T, Sakamoto A. The miRNA and mRNA changes in rat hippocampi after chronic constriction injury. Pain Med. 2013;14:720\u20139.","journal-title":"Pain Med"},{"key":"3_CR122","first-page":"801.e1\u201312","volume":"15","author":"KW Poh","year":"2011","unstructured":"Poh KW, Yeo JF, Ong WY. MicroRNA changes in the mouse prefrontal cortex after inflammatory pain. Eur J Pain. 2011;15:801.e1\u201312.","journal-title":"Eur J Pain"},{"key":"3_CR123","doi-asserted-by":"publisher","first-page":"10251","DOI":"10.1523\/JNEUROSCI.2419-10.2010","volume":"30","author":"Y He","year":"2010","unstructured":"He Y, Yang C, Kirkmire CM, Wang ZJ. Regulation of opioid tolerance by let-7 family microRNA targeting the \u03bc opioid receptor. J Neurosci. 2010;30:10251\u20138.","journal-title":"J Neurosci"},{"key":"3_CR124","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3389\/fgene.2014.00164","volume":"5","author":"BS Clark","year":"2014","unstructured":"Clark BS, Blackshaw S. Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease. Front Genet. 2014;5:164.","journal-title":"Front Genet"},{"key":"3_CR125","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neulet.2012.12.014","volume":"534","author":"B Yu","year":"2013","unstructured":"Yu B, Zhou S, Hu W, Qian T, Gao R, Ding G, Ding F, Gu X. Altered long noncoding RNA expressions in dorsal root ganglion after rat sciatic nerve injury. Neurosci Lett. 2013;534:117\u201322.","journal-title":"Neurosci Lett"},{"key":"3_CR126","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/nn.3438","volume":"16","author":"X Zhao","year":"2013","unstructured":"Zhao X, Tang Z, Zhang H, Atianjoh FE, Zhao JY, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, Tao YX. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nat Neurosci. 2013;16:1024\u201331.","journal-title":"Nat Neurosci"},{"key":"3_CR127","first-page":"1","volume":"36","author":"L Vannucci","year":"2013","unstructured":"Vannucci L, Lai M, Chiuppesi F, Ceccherini-Nelli L, Pistello M. Viral vectors: a look back and ahead on gene transfer technology. New Microbiol. 2013;36:1\u201322.","journal-title":"New Microbiol"},{"key":"3_CR128","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.jpain.2011.04.003","volume":"12","author":"K Takasu","year":"2011","unstructured":"Takasu K, Sakai A, Hanawa H, Shimada T, Suzuki H. Overexpression of GDNF in the uninjured DRG exerts analgesic effects on neuropathic pain following segmental spinal nerve ligation in mice. J Pain. 2011;12:1130\u20139.","journal-title":"J Pain"},{"key":"3_CR129","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1744-8069-10-54","volume":"10","author":"J Pleticha","year":"2014","unstructured":"Pleticha J, Heilmann LF, Evans CH, Asokan A, Samulski RJ, Beutler AS. Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs. Mol Pain. 2014;10:54.","journal-title":"Mol Pain"},{"key":"3_CR130","first-page":"71","volume":"7","author":"JR Goss","year":"2014","unstructured":"Goss JR, Krisky D, Wechuck J, Wolfe D. Herpes simplex virus-based nerve targeting gene therapy in pain management. J Pain Res. 2014;7:71\u20139.","journal-title":"J Pain Res"},{"key":"3_CR131","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nbt.1807","volume":"29","author":"L Alvarez-Erviti","year":"2011","unstructured":"Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJA. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341\u20135.","journal-title":"Nat Biotechnol"},{"key":"3_CR132","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.pain.2014.04.029","volume":"155","author":"MK McDonald","year":"2014","unstructured":"McDonald MK, Tian Y, Qureshi RA, Gormley M, Ertel A, Gao R, Lopez EA, Alexander GM, Sacan A, Fortina P, Ajit SK. Functional significance of macrophage-derived exosomes in inflammation and pain. Pain. 2014;155:1527\u201339.","journal-title":"Pain"}],"container-title":["Advances in Experimental Medicine and Biology","microRNA: Medical Evidence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-22671-2_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T19:14:52Z","timestamp":1676661292000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-319-22671-2_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9783319226705","9783319226712"],"references-count":132,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-22671-2_3","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}