{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:12:24Z","timestamp":1793401944387,"version":"4.5.0"},"publisher-location":"Cham","reference-count":259,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319228211","type":"print"},{"value":"9783319228228","type":"electronic"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-3-319-22822-8_8","type":"book-chapter","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T02:26:16Z","timestamp":1443579976000},"page":"151-209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["EBV Persistence\u2014Introducing the Virus"],"prefix":"10.1007","author":[{"given":"David A.","family":"Thorley-Lawson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"key":"8_CR1","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1073\/pnas.72.4.1477","volume":"72","author":"A Adams","year":"1975","unstructured":"Adams A, Lindahl T (1975) Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cells. Proc Natl Acad Sci USA 72:1477\u20131481","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR2","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.semcancer.2009.07.007","volume":"19","author":"MJ Allday","year":"2009","unstructured":"Allday MJ (2009) How does Epstein-Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt\u2019s lymphoma? Semin Cancer Biol 19:366\u2013376","journal-title":"Semin Cancer Biol"},{"key":"8_CR3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3389\/fgene.2013.00212","volume":"4","author":"MJ Allday","year":"2013","unstructured":"Allday MJ (2013) EBV finds a polycomb-mediated, epigenetic solution to the problem of oncogenic stress responses triggered by infection. Front Genet 4:212","journal-title":"Front Genet"},{"key":"8_CR4","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1099\/0022-1317-70-7-1755","volume":"70","author":"MJ Allday","year":"1989","unstructured":"Allday MJ, Crawford DH, Griffin BE (1989) Epstein-Barr virus latent gene expression during the initiation of B cell immortalization. J Gen Virol 70:1755\u20131764","journal-title":"J Gen Virol"},{"key":"8_CR5","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/j.1460-2075.1995.tb07124.x","volume":"14","author":"MJ Allday","year":"1995","unstructured":"Allday MJ, Sinclair A, Parker G, Crawford DH, Farrell PJ (1995) Epstein-Barr virus efficiently immortalizes human B cells without neutralizing the function of p53. EMBO J 14:1382\u20131391","journal-title":"EMBO J"},{"key":"8_CR6","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/ni1100","volume":"5","author":"CD Allen","year":"2004","unstructured":"Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG (2004) Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol 5:943\u2013952","journal-title":"Nat Immunol"},{"issue":"1","key":"8_CR7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1182\/asheducation-2007.1.204","volume":"2007","author":"R. F. Ambinder","year":"2007","unstructured":"Ambinder RF (2007) Epstein-barr virus and hodgkin lymphoma. Hematol Am Soc Hematol Educ Program 2007:204\u2013209","journal-title":"Hematology"},{"key":"8_CR8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1182\/blood.V85.3.744.bloodjournal853744","volume":"85","author":"I Anagnostopoulos","year":"1995","unstructured":"Anagnostopoulos I, Hummel M, Kreschel C, Stein H (1995) Morphology, immunophenotype, and distribution of latently and\/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein-Barr virus. Blood 85:744\u2013750","journal-title":"Blood"},{"key":"8_CR9","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/ijc.2910200403","volume":"20","author":"M Andersson-Anvret","year":"1977","unstructured":"Andersson-Anvret M, Forsby N, Klein G, Henle W (1977) Relationship between the Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma: correlated nucleic acid hybridization and histopathological examination. Int J Cancer 20:486\u2013494","journal-title":"Int J Cancer"},{"key":"8_CR10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1128\/jvi.41.2.376-389.1982","volume":"41","author":"JJ Arrand","year":"1982","unstructured":"Arrand JJ, Rymo L (1982) Characterisation of the major Epstein-Barr virus specific RNA in Burkitt lymphoma derived cells. J Virol 41:376\u2013389","journal-title":"J Virol"},{"key":"8_CR11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1126\/science.7716513","volume":"268","author":"S Artavanis-Tsakonas","year":"1995","unstructured":"Artavanis-Tsakonas S, Matsuno K, Fortini ME (1995) Notch signaling. Science 268:225\u2013232","journal-title":"Science"},{"key":"8_CR12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1365-2249.2010.04121.x","volume":"160","author":"A Ascherio","year":"2010","unstructured":"Ascherio A, Munger KL (2010) 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Epstein-Barr virus and multiple sclerosis: epidemiological evidence. Clin Exp Immunol 160:120\u2013124","journal-title":"Clin Exp Immunol"},{"key":"8_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S1074-7613(00)80622-6","volume":"9","author":"GJ Babcock","year":"1998","unstructured":"Babcock GJ, Decker LL, Volk M, Thorley-Lawson DA (1998) EBV persistence in memory B cells in vivo. Immunity 9:395\u2013404","journal-title":"Immunity"},{"key":"8_CR14","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1084\/jem.190.4.567","volume":"190","author":"GJ Babcock","year":"1999","unstructured":"Babcock GJ, Decker LL, Freeman RB, Thorley-Lawson DA (1999) Epstein-barr virus-infected resting memory B cells, not proliferating lymphoblasts, accumulate in the peripheral blood of immunosuppressed patients. J Exp Med 190:567\u2013576","journal-title":"J Exp Med"},{"key":"8_CR15","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S1074-7613(00)00049-2","volume":"13","author":"GJ Babcock","year":"2000","unstructured":"Babcock GJ, Hochberg D, Thorley-Lawson AD (2000) The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell. Immunity 13:497\u2013506","journal-title":"Immunity"},{"key":"8_CR16","first-page":"461","volume":"2","author":"VR Baichwal","year":"1988","unstructured":"Baichwal VR, Sugden B (1988) Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus. Oncogene 2:461\u2013467","journal-title":"Oncogene"},{"key":"8_CR17","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1146\/annurev.iy.12.040194.004313","volume":"12","author":"J Banchereau","year":"1994","unstructured":"Banchereau J, Bazan F, Blanchard D, Briere F, Galizzi JP, Van KC, Liu YJ, Rousset F, Saeland S (1994) The CD40 antigen and its ligand. Annu Rev Immunol 12:881\u2013922","journal-title":"Annu Rev Immunol"},{"key":"8_CR18","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1146\/annurev-immunol-072710-081639","volume":"29","author":"E Barton","year":"2011","unstructured":"Barton E, Mandal P, Speck SH (2011) Pathogenesis and host control of gammaherpesviruses: lessons from the mouse. Annu Rev Immunol 29:351\u2013397","journal-title":"Annu Rev Immunol"},{"issue":"1-3","key":"8_CR19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12026-008-8048-7","volume":"42","author":"Hamid Bassiri","year":"2008","unstructured":"Bassiri H, Janice YEO WC, Rothman J, Koretzky GA, Nichols KE (2008) X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunol Res 42:145\u2013159","journal-title":"Immunologic Research"},{"key":"8_CR20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0065-2776(10)05007-8","volume":"105","author":"K Basso","year":"2010","unstructured":"Basso K, Dalla-Favera R (2010) BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis. Adv Immunol 105:193\u2013210","journal-title":"Adv Immunol"},{"key":"8_CR21","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1002\/j.1460-2075.1993.tb06205.x","volume":"12","author":"P Beaufils","year":"1993","unstructured":"Beaufils P, Choquet D, Mamoun RZ, Malissen B (1993) The (YXXL\/I)2 signalling motif found in the cytoplasmic segments of the bovine leukaemia virus envelope protein and Epstein-Barr virus latent membrane protein 2A can elicit early and late lymphocyte activation events. EMBO J 12:5105\u20135112","journal-title":"EMBO J"},{"key":"8_CR22","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1182\/blood-2005-06-2342","volume":"106","author":"D Bechtel","year":"2005","unstructured":"Bechtel D, Kurth J, Unkel C, Kuppers R (2005) Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas. Blood 106:4345\u20134350","journal-title":"Blood"},{"key":"8_CR23","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1126\/science.1076071","volume":"298","author":"NL Bernasconi","year":"2002","unstructured":"Bernasconi NL, Traggiai E, Lanzavecchia A (2002) Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298:2199\u20132202","journal-title":"Science"},{"key":"8_CR24","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1128\/jvi.67.4.2209-2220.1993","volume":"67","author":"M Birkenbach","year":"1993","unstructured":"Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (1993) Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J Virol 67:2209\u20132220","journal-title":"J Virol"},{"key":"8_CR25","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1093\/jnci\/91.16.1376","volume":"91","author":"M Bonnet","year":"1999","unstructured":"Bonnet M, Guinebretiere JM, Kremmer E, Grunewald V, Benhamou E, Contesso G, Joab I (1999) Detection of Epstein-Barr virus in invasive breast cancers. J Natl Cancer Inst 91:1376\u20131381","journal-title":"J Natl Cancer Inst"},{"key":"8_CR26","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nm0602-594","volume":"8","author":"CM Borza","year":"2002","unstructured":"Borza CM, Hutt-Fletcher LM (2002) Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus. Nat Med 8:594\u2013599","journal-title":"Nat Med"},{"key":"8_CR27","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0167-5699(98)01413-3","volume":"20","author":"P Brandtzaeg","year":"1999","unstructured":"Brandtzaeg P, Baekkevold ES, Farstad IN, Jahnsen FL, Johansen FE, Nilsen EM, Yamanaka T (1999a) Regional specialization in the mucosal immune system: what happens in the microcompartments? Immunol Today 20:141\u2013151","journal-title":"Immunol Today"},{"key":"8_CR28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0167-5699(99)01468-1","volume":"20","author":"P Brandtzaeg","year":"1999","unstructured":"Brandtzaeg P, Farstad IN, Haraldsen G (1999b) Regional specialization in the mucosal immune system: primed cells do not always home along the same track. Immunol Today 20:267\u2013277","journal-title":"Immunol Today"},{"key":"8_CR29","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1146\/annurev.immunol.21.120601.141138","volume":"21","author":"KL Calame","year":"2003","unstructured":"Calame KL, Lin KI, Tunyaplin C (2003) Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol 21:205\u2013230 Epub 2001 Dec 19","journal-title":"Annu Rev Immunol"},{"key":"8_CR30","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S1074-7613(00)80623-8","volume":"9","author":"RG Caldwell","year":"1998","unstructured":"Caldwell RG, Wilson JB, Anderson SJ, Longnecker R (1998) Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity 9:405\u2013411","journal-title":"Immunity"},{"key":"8_CR31","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<4382::AID-IMMU4382>3.0.CO;2-Z","volume":"28","author":"MF Callan","year":"1998","unstructured":"Callan MF, Annels N, Steven N, Tan L, Wilson J, McMichael AJ, Rickinson AB (1998a) T cell selection during the evolution of CD8+\u00a0T cell memory in vivo. Eur J Immunol 28:4382\u20134390","journal-title":"Eur J Immunol"},{"key":"8_CR32","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1084\/jem.187.9.1395","volume":"187","author":"MF Callan","year":"1998","unstructured":"Callan MF, Tan L, Annels N, Ogg GS, Wilson JD, O\u2019Callaghan CA, Steven N, McMichael AJ, Rickinson AB (1998b) Direct visualization of antigen-specific CD8+\u00a0T cells during the primary immune response to Epstein-Barr virus In vivo. J Exp Med 187:1395\u20131402","journal-title":"J Exp Med"},{"key":"8_CR33","first-page":"747","volume":"91","author":"A Carbone","year":"1998","unstructured":"Carbone A, Gaidano G, Gloghini A, Larocca LM, Capello D, Canzonieri V, Antinori A, Tirelli U, Falini B, Dalla-Favera R (1998) Differential expression of BCL-6, CD138\/syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immunodeficiency syndrome-related non-Hodgkin\u2019s lymphomas. Blood 91:747\u2013755","journal-title":"Blood"},{"key":"8_CR34","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/ni1036","volume":"5","author":"S Casola","year":"2004","unstructured":"Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC, Rajewsky K (2004a) B cell receptor signal strength determines B cell fate. Nat Immunol 5:317\u2013327","journal-title":"Nat Immunol"},{"issue":"3","key":"8_CR35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/ni1036","volume":"5","author":"Stefano Casola","year":"2004","unstructured":"Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC, Rajewsky K (2004b) B cell receptor signal strength determines B cell fate. Nat Immunol 5:317\u2013327","journal-title":"Nature Immunology"},{"key":"8_CR36","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.4049\/jimmunol.167.8.4450","volume":"167","author":"MD Catalina","year":"2001","unstructured":"Catalina MD, Sullivan JL, Bak KR, Luzuriaga K (2001) Differential evolution and stability of epitope-specific CD8(+) T cell responses in EBV infection. J Immunol 167:4450\u20134457","journal-title":"J Immunol"},{"key":"8_CR37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V86.1.45.bloodjournal86145","volume":"86","author":"G Cattoretti","year":"1995","unstructured":"Cattoretti G, Chang CC, Cechova K, Zhang J, Ye BH, Falini B, Louie DC, Offit K, Chaganti RS, Dalla-Favera R (1995) BCL-6 protein is expressed in germinal-center B cells. Blood 86:45\u201353","journal-title":"Blood"},{"key":"8_CR38","doi-asserted-by":"publisher","first-page":"6372","DOI":"10.1182\/blood-2008-08-175828","volume":"113","author":"S Chaganti","year":"2009","unstructured":"Chaganti S, Heath EM, Bergler W, Kuo M, Buettner M, Niedobitek G, Rickinson AB, Bell AI (2009) Epstein-Barr virus colonization of tonsillar and peripheral blood B-cell subsets in primary infection and persistence. Blood 113:6372\u20136381","journal-title":"Blood"},{"key":"8_CR39","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/srep00353","volume":"2","author":"RA Chang","year":"2012","unstructured":"Chang RA, Miller SD, Longnecker R (2012) Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function. Sci Rep 2:353","journal-title":"Sci Rep"},{"key":"8_CR40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jim.2014.04.009","volume":"410","author":"Bithi Chatterjee","year":"2014","unstructured":"Chatterjee B, Leung CS, Munz C (2014) Animal models of Epstein Barr virus infection. J Immunol Methods 40:80\u201387","journal-title":"Journal of Immunological Methods"},{"key":"8_CR41","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1128\/jvi.69.6.3752-3758.1995","volume":"69","author":"F Chen","year":"1995","unstructured":"Chen F, Zou JZ, Di RL, Winberg G, Hu LF, Klein E, Klein G, Ernberg I (1995) A subpopulation of normal B cells latently infected with Epstein-Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1. J Virol 69:3752\u20133758","journal-title":"J Virol"},{"key":"8_CR42","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/(SICI)1097-0215(19961104)68:3<285::AID-IJC3>3.0.CO;2-Y","volume":"68","author":"AK Chiang","year":"1996","unstructured":"Chiang AK, Tao Q, Srivastava G, Ho FC (1996) Nasal NK- and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin\u2019s disease. Int J Cancer 68:285\u2013290","journal-title":"Int J Cancer"},{"key":"8_CR43","doi-asserted-by":"publisher","first-page":"6753","DOI":"10.4049\/jimmunol.1000812","volume":"185","author":"SC Clute","year":"2010","unstructured":"Clute SC, Naumov YN, Watkin LB, Aslan N, Sullivan JL, Thorley-Lawson DA, Luzuriaga K, Welsh RM, Puzone R, Celada F, Selin LK (2010) Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes. J Immunol 185:6753\u20136764","journal-title":"J Immunol"},{"key":"8_CR44","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/2424","volume":"20","author":"AJ Coffey","year":"1998","unstructured":"Coffey AJ, Brooksbank RA, Brandau O, Oohashi T, Howell GR, Bye JM, Cahn AP, Durham J, Heath P, Wray P, Pavitt R, Wilkinson J, Leversha M, Huckle E, Shaw-Smith CJ, Dunham A, Rhodes S, Schuster V, Porta G, Yin L, Serafini P, Sylla B, Zollo M, Franco B, Bentley DR et al (1998) Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet 20:129\u2013135","journal-title":"Nat Genet"},{"key":"8_CR45","doi-asserted-by":"publisher","first-page":"e1004106","DOI":"10.1371\/journal.ppat.1004106","volume":"10","author":"CM Collins","year":"2014","unstructured":"Collins CM, Speck SH (2014) Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help. PLoS Pathog 10:e1004106","journal-title":"PLoS Pathog"},{"key":"8_CR46","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nature01318","volume":"421","author":"S Crotty","year":"2003","unstructured":"Crotty S, Kersh EN, Cannons J, Schwartzberg PL, Ahmed R (2003) SAP is required for generating long-term humoral immunity. Nature 421:282\u2013287","journal-title":"Nature"},{"key":"8_CR47","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/path.4431","volume":"235","author":"C Daskalogianni","year":"2014","unstructured":"Daskalogianni C, Pyndiah S, Apcher S, Mazars A, Manoury B, Ammari N, Nylander K, Voisset C, Blondel M, Fahraeus R (2014) Epstein-Barr virus-encoded EBNA1 and ZEBRA: targets for therapeutic strategies against EBV-carrying cancers. J Pathol 235:334\u2013341","journal-title":"J Pathol"},{"key":"8_CR48","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1084\/jem.177.2.339","volume":"177","author":"EM Deacon","year":"1993","unstructured":"Deacon EM, Pallesen G, Niedobitek G, Crocker J, Brooks L, Rickinson AB, Young LS (1993) Epstein-Barr virus and Hodgkin\u2019s disease: transcriptional analysis of virus latency in the malignant cells. J Exp Med 177:339\u2013349","journal-title":"J Exp Med"},{"key":"8_CR49","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1128\/jvi.70.5.3286-3289.1996","volume":"70","author":"LL Decker","year":"1996","unstructured":"Decker LL, Klaman LD, Thorley-Lawson DA (1996) Detection of the latent form of Epstein-Barr virus DNA in the peripheral blood of healthy individuals. J Virol 70:3286\u20133289","journal-title":"J Virol"},{"key":"8_CR50","first-page":"111","volume":"174","author":"LL Decker","year":"2001","unstructured":"Decker LL, Babcock GJ, Thorley-Lawson DA (2001) Detection and discrimination of latent and replicative herpesvirus infection at the single cell level in vivo. Methods Mol Biol 174:111\u2013116","journal-title":"Methods Mol Biol"},{"key":"8_CR51","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1136\/mp.53.5.270","volume":"53","author":"HJ Delecluse","year":"2000","unstructured":"Delecluse HJ, Hammerschmidt W (2000) The genetic approach to the Epstein-Barr virus: from basic virology to gene therapy. Mol Pathol 53:270\u2013279","journal-title":"Mol Pathol"},{"key":"8_CR52","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00285-010-0365-5","volume":"63","author":"E Delgado-Eckert","year":"2011","unstructured":"Delgado-Eckert E, Shapiro M (2011) A model of host response to a multi-stage pathogen. J Math Biol 63:201\u2013227","journal-title":"J Math Biol"},{"key":"8_CR53","volume-title":"Burkitt\u2019s Lymphoma a human cancer model","author":"G DE-THE","year":"1985","unstructured":"de-Th\u00e9 G (1985) Epstein-Barr virus and Burkitt\u2019s lymphoma worldwide: the causal relationship revisited. In: Olweny CLM, Lenoir GM, O\u2019conor GT (eds) Burkitt\u2019s Lymphoma a human cancer model. Oxford University Press, New York"},{"key":"8_CR54","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/ni.2428","volume":"13","author":"D Dominguez-Sola","year":"2012","unstructured":"Dominguez-Sola D, Victora GD, Ying CY, Phan RT, Saito M, Nussenzweig MC, Dalla-Favera R (2012) The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol 13:1083\u20131091","journal-title":"Nat Immunol"},{"key":"8_CR55","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1749-6632.2003.tb06039.x","volume":"987","author":"M Dono","year":"2003","unstructured":"Dono M, Zupo S, Colombo M, Massara R, Gaidano G, Taborelli G, Ceppa P, Burgio VL, Chiorazzi N, Ferrarini M (2003) The human marginal zone B cell. Ann N Y Acad Sci 987:117\u2013124","journal-title":"Ann N Y Acad Sci"},{"key":"8_CR56","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1182\/blood-2004-08-3269","volume":"105","author":"L Dupre","year":"2005","unstructured":"Dupre L, Andolfi G, Tangye SG, Clementi R, Locatelli F, Arico M, Aiuti A, Roncarolo MG (2005) SAP controls the cytolytic activity of CD8+\u00a0T cells against EBV-infected cells. Blood 105:4383\u20134389","journal-title":"Blood"},{"key":"8_CR57","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1128\/jvi.39.1.172-184.1981","volume":"39","author":"CM Edson","year":"1981","unstructured":"Edson CM, Thorley-Lawson DA (1981) Epstein-Barr virus membrane antigens: characterization, distribution, and strain differences. J Virol 39:172\u2013184","journal-title":"J Virol"},{"key":"8_CR58","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<50::AID-IJC10>3.0.CO;2-1","volume":"83","author":"B Ehlin-Henriksson","year":"1999","unstructured":"Ehlin-Henriksson B, Zou JZ, Klein G, Ernberg I (1999) Epstein-Barr virus genomes are found predominantly in IgA-positive B cells in the blood of healthy carriers. Int J Cancer 83:50\u201354","journal-title":"Int J Cancer"},{"key":"8_CR59","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1128\/JVI.73.2.1555-1564.1999","volume":"73","author":"GC Faulkner","year":"1999","unstructured":"Faulkner GC, Burrows SR, Khanna R, Moss DJ, Bird AG, Crawford DH (1999) X-Linked agammaglobulinemia patients are not infected with Epstein-Barr virus: implications for the biology of the virus. J Virol 73:1555\u20131564","journal-title":"J Virol"},{"key":"8_CR60","doi-asserted-by":"publisher","first-page":"4510","DOI":"10.1073\/pnas.81.14.4510","volume":"81","author":"JD Fingeroth","year":"1984","unstructured":"Fingeroth JD, Weis JJ, Tedder TF, Strominger JL, Biro PA, Fearon DT (1984) Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci USA 81:4510\u20134514","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR61","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0889-857X(21)00847-4","volume":"13","author":"RI Fox","year":"1987","unstructured":"Fox RI, Chilton T, Scott S, Benton L, Howell FV, Vaughan JH (1987) Potential role of Epstein-Barr virus in Sjogren\u2019s syndrome. Rheum Dis Clin North Am 13:275\u2013292","journal-title":"Rheum Dis Clin North Am"},{"key":"8_CR62","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.it.2013.01.007","volume":"34","author":"D Gatto","year":"2013","unstructured":"Gatto D, Brink R (2013) B cell localization: regulation by EBI2 and its oxysterol ligand. Trends Immunol 34:336\u2013341","journal-title":"Trends Immunol"},{"key":"8_CR63","doi-asserted-by":"publisher","first-page":"6131","DOI":"10.1093\/emboj\/16.20.6131","volume":"16","author":"O Gires","year":"1997","unstructured":"Gires O, Zimber-Strobl U, Gonnella R, Ueffing M, Marschall G, Zeidler R, Pich D, Hammerschmidt W (1997) Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. EMBO J 16:6131\u20136140","journal-title":"EMBO J"},{"key":"8_CR64","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/(SICI)1097-0215(19970207)70:4<375::AID-IJC1>3.0.CO;2-T","volume":"70","author":"SL Glaser","year":"1997","unstructured":"Glaser SL, Lin RJ, Stewart SL, Ambinder RF, Jarrett RF, Brousset P, Pallesen G, Gulley ML, Khan G, O\u2019Grady J, Hummel M, Preciado MV, Knecht H, Chan JK, Claviez A (1997) Epstein-Barr virus-associated Hodgkin\u2019s disease: epidemiologic characteristics in international data. Int J Cancer 70:375\u2013382","journal-title":"Int J Cancer"},{"key":"8_CR65","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/infdis\/127.4.471","volume":"127","author":"HD Golden","year":"1973","unstructured":"Golden HD, Chang RS, Prescott W, Simpson E, Cooper TY (1973) Leukocyte-transforming agent: prolonged excretion by patients with mononucleosis and excretion by normal individuals. J Infect Dis 127:471\u2013473","journal-title":"J Infect Dis"},{"key":"8_CR66","doi-asserted-by":"publisher","first-page":"8693","DOI":"10.1073\/pnas.85.22.8693","volume":"85","author":"JW Gratama","year":"1988","unstructured":"Gratama JW, Oosterveer MA, Zwaan FE, Lepoutre J, Klein G, Ernberg I (1988) Eradication of Epstein-Barr virus by allogeneic bone marrow transplantation: implications for sites of viral latency. Proc Natl Acad Sci USA 85:8693\u20138696","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR67","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/eji.1830120707","volume":"12","author":"D Gray","year":"1982","unstructured":"Gray D, Maclennan IC, Bazin H, Khan M (1982) Migrant mu+\u00a0delta+\u00a0and static mu+\u00a0delta-B lymphocyte subsets. Eur J Immunol 12:564\u2013569","journal-title":"Eur J Immunol"},{"key":"8_CR68","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJM198512193132502","volume":"313","author":"JS Greenspan","year":"1985","unstructured":"Greenspan JS, Greenspan D, Lennette ET, Abrams DI, Conant MA, Petersen V, Freese UK (1985) Replication of Epstein-Barr virus within the epithelial cells of oral \u201chairy\u201d leukoplakia, an AIDS-associated lesion. N Engl J Med 313:1564\u20131571","journal-title":"N Engl J Med"},{"key":"8_CR69","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4049\/jimmunol.139.1.313","volume":"139","author":"CD Gregory","year":"1987","unstructured":"Gregory CD, Tursz T, Edwards CF, Tetaud C, Talbot M, Caillou B, Rickinson AB, Lipinski M (1987) Identification of a subset of normal B cells with a Burkitt\u2019s lymphoma (BL)-like phenotype. J Immunol 139:313\u2013318","journal-title":"J Immunol"},{"key":"8_CR70","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1099\/0022-1317-71-7-1481","volume":"71","author":"CD Gregory","year":"1990","unstructured":"Gregory CD, Rowe M, Rickinson AB (1990) Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt\u2019s lymphoma cell line. J Gen Virol 71:1481\u20131495","journal-title":"J Gen Virol"},{"key":"8_CR71","doi-asserted-by":"publisher","first-page":"6599","DOI":"10.4049\/jimmunol.174.11.6599","volume":"174","author":"AJ Gross","year":"2005","unstructured":"Gross AJ, Hochberg D, Rand WM, Thorley-Lawson DA (2005) EBV and systemic lupus erythematosus: a new perspective. J Immunol 174:6599\u20136607","journal-title":"J Immunol"},{"key":"8_CR72","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/1097-0142(19920701)70:1<185::AID-CNCR2820700129>3.0.CO;2-J","volume":"70","author":"ML Gulley","year":"1992","unstructured":"Gulley ML, Raphael M, Lutz CT, Ross DW, Raab-Traub N (1992) Epstein-Barr virus integration in human lymphomas and lymphoid cell lines. Cancer 70:185\u2013191","journal-title":"Cancer"},{"key":"8_CR73","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1182\/blood-2007-06-093278","volume":"111","author":"V Hadinoto","year":"2008","unstructured":"Hadinoto V, Shapiro M, Greenough TC, Sullivan JL, Luzuriaga K, Thorley-Lawson DA (2008) On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood 111:1420\u20131427","journal-title":"Blood"},{"key":"8_CR74","doi-asserted-by":"publisher","first-page":"e1000496","DOI":"10.1371\/journal.ppat.1000496","volume":"5","author":"V Hadinoto","year":"2009","unstructured":"Hadinoto V, Shapiro M, Sun CC, Thorley-Lawson DA (2009) The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output. PLoS Pathog 5:e1000496","journal-title":"PLoS Pathog"},{"key":"8_CR75","volume-title":"Chapter 7: B Lymphocyte Development and Biology. Fundamental Immunology","author":"R Hardy","year":"2008","unstructured":"Hardy R (2008) Chapter 7: B Lymphocyte Development and Biology. Fundamental Immunology, 6th edn. Lippincott Williams and Wilkins, Philadelphia","edition":"6"},{"key":"8_CR76","doi-asserted-by":"publisher","first-page":"e1003685","DOI":"10.1371\/journal.ppat.1003685","volume":"9","author":"JB Hawkins","year":"2013","unstructured":"Hawkins JB, Delgado-Eckert E, Thorley-Lawson DA, Shapiro M (2013) The cycle of EBV infection explains persistence, the sizes of the infected cell populations and which come under CTL regulation. PLoS Pathog 9:e1003685","journal-title":"PLoS Pathog"},{"key":"8_CR77","doi-asserted-by":"publisher","first-page":"5215","DOI":"10.4049\/jimmunol.171.10.5215","volume":"171","author":"B He","year":"2003","unstructured":"He B, Raab-Traub N, Casali P, Cerutti A (2003) EBV-encoded latent membrane protein 1 cooperates with BAFF\/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching. J Immunol 171:5215\u20135224","journal-title":"J Immunol"},{"key":"8_CR78","doi-asserted-by":"publisher","first-page":"e1002697","DOI":"10.1371\/journal.ppat.1002697","volume":"8","author":"E Heath","year":"2012","unstructured":"Heath E, Begue-Pastor N, Chaganti S, Croom-Carter D, Shannon-Lowe C, Kube D, Feederle R, Delecluse HJ, Rickinson AB, Bell AI (2012) Epstein-Barr virus infection of naive B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology. PLoS Pathog 8:e1002697","journal-title":"PLoS Pathog"},{"key":"8_CR79","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/0092-8674(91)90007-L","volume":"65","author":"S Henderson","year":"1991","unstructured":"Henderson S, Rowe M, Gregory C, Croom-Carter D, Wang F, Longnecker R, Kieff E, Rickinson A (1991) Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 65:1107\u20131115","journal-title":"Cell"},{"key":"8_CR80","doi-asserted-by":"publisher","first-page":"8479","DOI":"10.1073\/pnas.90.18.8479","volume":"90","author":"S Henderson","year":"1993","unstructured":"Henderson S, Huen D, Rowe M, Dawson C, Johnson G, Rickinson A (1993) Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc Natl Acad Sci USA 90:8479\u20138483","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR81","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-642-67236-1_4","volume-title":"The Epstein-Barr Virus","author":"W. Henle","year":"1979","unstructured":"Henle W, Henle G (1979) Seroepidemiology of the virus. In: Epstein MA, Achong BG (eds) The Epstein-Barr virus. Springer, Berlin"},{"issue":"3792","key":"8_CR82","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.157.3792.1064","volume":"157","author":"W. Henle","year":"1967","unstructured":"Henle W, Diehl V, Kohn G, Zur Hausen H, Henle G (1967) Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells. Science 157:1064\u20131065","journal-title":"Science"},{"key":"8_CR83","doi-asserted-by":"publisher","first-page":"4766","DOI":"10.1073\/pnas.88.11.4766","volume":"88","author":"H Herbst","year":"1991","unstructured":"Herbst H, Dallenbach F, Hummel M, Niedobitek G, Pileri S, Muller LN, Stein H (1991) Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells. Proc Natl Acad Sci USA 88:4766\u20134770","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR84","doi-asserted-by":"publisher","first-page":"47197","DOI":"10.1074\/jbc.M208116200","volume":"277","author":"M Hickabottom","year":"2002","unstructured":"Hickabottom M, Parker GA, Freemont P, Crook T, Allday MJ (2002) Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP). J Biol Chem 277:47197\u201347204 (Epub 2002 Oct 7)","journal-title":"J Biol Chem"},{"key":"8_CR85","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1172\/JCI24810","volume":"115","author":"AD Hislop","year":"2005","unstructured":"Hislop AD, Kuo M, Drake-Lee AB, Akbar AN, Bergler W, Hammerschmitt N, Khan N, Palendira U, Leese AM, Timms JM, Bell AI, Buckley CD, Rickinson AB (2005) Tonsillar homing of Epstein-Barr virus-specific CD8+\u00a0T cells and the virus-host balance. J Clin Invest 115:2546\u20132555","journal-title":"J Clin Invest"},{"key":"8_CR86","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1158\/0008-5472.CAN-06-3566","volume":"67","author":"H Hjalgrim","year":"2007","unstructured":"Hjalgrim H, Smedby KE, Rostgaard K, Molin D, Hamilton-Dutoit S, Chang ET, Ralfkiaer E, Sundstrom C, Adami HO, Glimelius B, Melbye M (2007) Infectious mononucleosis, childhood social environment, and risk of Hodgkin lymphoma. Cancer Res 67:2382\u20132388","journal-title":"Cancer Res"},{"key":"8_CR87","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/00000441-195503000-00003","volume":"229","author":"RJ Hoagland","year":"1955","unstructured":"Hoagland RJ (1955) The transmission of infectious mononucleosis. Am J Med Sci 229:262\u2013272","journal-title":"Am J Med Sci"},{"key":"8_CR88","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.2105\/AJPH.54.10.1699","volume":"54","author":"RJ Hoagland","year":"1964","unstructured":"Hoagland RJ (1964) The incubation period of infectious mononucleosis. Am J Public Health Nations Health 54:1699\u20131705","journal-title":"Am J Public Health Nations Health"},{"key":"8_CR89","volume-title":"Infectious mononucleosis. Infectious mononucleosis","author":"RJ Hoagland","year":"1967","unstructured":"Hoagland RJ (1967) Infectious mononucleosis. Infectious mononucleosis. Grune and Stratton Inc, New York\/London"},{"key":"8_CR90","first-page":"39","volume":"292","author":"DR Hochberg","year":"2005","unstructured":"Hochberg DR, Thorley-Lawson DA (2005) Quantitative detection of viral gene expression in populations of Epstein-Barr virus-infected cells in vivo. Methods Mol Biol 292:39\u201356","journal-title":"Methods Mol Biol"},{"key":"8_CR91","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1073\/pnas.2237267100","volume":"101","author":"D Hochberg","year":"2003","unstructured":"Hochberg D, Middeldorp JM, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA (2003a) Demonstration of the Burkitt\u2019s Lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci USA 101:239\u2013244","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR92","doi-asserted-by":"crossref","unstructured":"Hochberg D, Vorobyova T, Catalina M, Sullivan JS, Luzuriaga K, Thorley-Lawson DA (2003b) Acute infection with Epstein-Bar virus targets and overwhelms the memory B cell compartment with latently infected cells (Submitted)","DOI":"10.1128\/JVI.78.10.5194-5204.2004"},{"key":"8_CR93","doi-asserted-by":"crossref","unstructured":"Hochberg D, Souza T, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA (2004) Acute infection with Epstein-Bar virus targets and overwhelms the peripheral memory B cell compartment with resting, latently infected cells. J Virol (in press)","DOI":"10.1128\/JVI.78.10.5194-5204.2004"},{"key":"8_CR94","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1136\/jcp.53.4.248","volume":"53","author":"P Hopwood","year":"2000","unstructured":"Hopwood P, Crawford DH (2000) The role of EBV in post-transplant malignancies: a review. J Clin Pathol 53:248\u2013254","journal-title":"J Clin Pathol"},{"key":"8_CR95","doi-asserted-by":"publisher","first-page":"11857","DOI":"10.1128\/JVI.01005-09","volume":"83","author":"Y Hoshino","year":"2009","unstructured":"Hoshino Y, Katano H, Zou P, Hohman P, Marques A, Tyring SK, Follmann D, Cohen JI (2009) Long-term administration of valacyclovir reduces the number of Epstein-Barr virus (EBV)-infected B cells but not the number of EBV DNA copies per B cell in healthy volunteers. J Virol 83:11857\u201311861","journal-title":"J Virol"},{"key":"8_CR96","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1084\/jem.168.6.2059","volume":"168","author":"EA Hurley","year":"1988","unstructured":"Hurley EA, Thorley-Lawson DA (1988) B cell activation and the establishment of Epstein-Barr virus latency. J Exp Med 168:2059\u20132075","journal-title":"J Exp Med"},{"key":"8_CR97","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1128\/JVI.75.5.2400-2410.2001","volume":"75","author":"GJ Inman","year":"2001","unstructured":"Inman GJ, Binne UK, Parker GA, Farrell PJ, Allday MJ (2001) Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death. J Virol 75:2400\u20132410","journal-title":"J Virol"},{"key":"8_CR98","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.3390\/cancers6031615","volume":"6","author":"D Iwakiri","year":"2014","unstructured":"Iwakiri D (2014) Epstein-Barr virus-encoded RNAs: key molecules in viral pathogenesis. Cancers (Basel) 6:1615\u20131630","journal-title":"Cancers (Basel)"},{"key":"8_CR99","doi-asserted-by":"publisher","first-page":"12592","DOI":"10.1073\/pnas.94.23.12592","volume":"94","author":"KM Izumi","year":"1997","unstructured":"Izumi KM, Kieff ED (1997) The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF- kappaB. Proc Natl Acad Sci USA 94:12592\u201312597","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR100","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1172\/JCI119856","volume":"100","author":"JA James","year":"1997","unstructured":"James JA, Kaufman KM, Farris AD, Taylor-Albert E, Lehman TJ, Harley JB (1997) An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. J Clin Invest 100:3019\u20133026","journal-title":"J Clin Invest"},{"key":"8_CR101","doi-asserted-by":"publisher","first-page":"9964","DOI":"10.1128\/JVI.74.21.9964-9971.2000","volume":"74","author":"AM Joseph","year":"2000","unstructured":"Joseph AM, Babcock GJ, Thorley-Lawson DA (2000a) Cells expressing the Epstein-Barr virus growth program are present in and restricted to the naive B-cell subset of healthy tonsils. J Virol 74:9964\u20139971","journal-title":"J Virol"},{"key":"8_CR102","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.4049\/jimmunol.165.6.2975","volume":"165","author":"AM Joseph","year":"2000","unstructured":"Joseph AM, Babcock GJ, Thorley-Lawson DA (2000b) EBV persistence involves strict selection of latently infected B cells. J Immunol 165:2975\u20132981","journal-title":"J Immunol"},{"key":"8_CR103","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1128\/JVI.73.5.4481-4484.1999","volume":"73","author":"C Kaiser","year":"1999","unstructured":"Kaiser C, Laux G, Eick D, Jochner N, Bornkamm GW, Kempkes B (1999) The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2. J Virol 73:4481\u20134484","journal-title":"J Virol"},{"key":"8_CR104","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0167-5699(91)90136-H","volume":"12","author":"AB Kantor","year":"1991","unstructured":"Kantor AB (1991) The development and repertoire of B-1 cells (CD5 B cells). Immunol Today 12:389\u2013391","journal-title":"Immunol Today"},{"key":"8_CR105","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/j.1460-2075.1995.tb06978.x","volume":"14","author":"B Kempkes","year":"1995","unstructured":"Kempkes B, Spitkovsky D, Jansen-Durr P, Ellwart JW, Kremmer E, Delecluse HJ, Rottenberger C, Bornkamm GW, Hammerschmidt W (1995) B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2. EMBO J 14:88\u201396","journal-title":"EMBO J"},{"key":"8_CR106","doi-asserted-by":"publisher","first-page":"14269","DOI":"10.1073\/pnas.2336099100","volume":"100","author":"G Kennedy","year":"2003","unstructured":"Kennedy G, Komano J, Sugden B (2003) Epstein-Barr virus provides a survival factor to Burkitt\u2019s lymphomas. Proc Natl Acad Sci USA 100:14269\u201314274","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR107","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.semcancer.2014.01.002","volume":"26","author":"SC Kenney","year":"2014","unstructured":"Kenney SC, Mertz JE (2014) Regulation of the latent-lytic switch in Epstein-Barr virus. Semin Cancer Biol 26:60\u201368","journal-title":"Semin Cancer Biol"},{"key":"8_CR108","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S1074-7613(00)80493-8","volume":"5","author":"G Khan","year":"1996","unstructured":"Khan G, Miyashita EM, Yang B, Babcock GJ, Thorley-Lawson DA (1996) Is EBV persistence in vivo a model for B cell homeostasis? Immunity 5:173\u2013179","journal-title":"Immunity"},{"key":"8_CR109","doi-asserted-by":"crossref","first-page":"7429","DOI":"10.1128\/jvi.71.10.7429-7435.1997","volume":"71","author":"R Khanna","year":"1997","unstructured":"Khanna R, Burrows SR, Neisig A, Neefjes J, Moss DJ, Silins SL (1997) Hierarchy of Epstein-Barr virus-specific cytotoxic T-cell responses in individuals carrying different subtypes of an HLA allele: implications for epitope-based antiviral vaccines. J Virol 71:7429\u20137435","journal-title":"J Virol"},{"key":"8_CR110","unstructured":"Kieff E, Rickinson AB (2007) Epstein-Barr virus and its replication. In: Knipe DM, Howley PM (eds) Fields virology, 5th edn. Lippincott Williams & Wilkins, Philadelphia"},{"key":"8_CR111","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1128\/jvi.69.2.1280-1283.1995","volume":"69","author":"AL Kirchmaier","year":"1995","unstructured":"Kirchmaier AL, Sugden B (1995) Plasmid maintenance of derivatives of oriP of Epstein-Barr virus. J Virol 69:1280\u20131283","journal-title":"J Virol"},{"key":"8_CR112","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.imlet.2005.11.003","volume":"104","author":"LL Kis","year":"2006","unstructured":"Kis LL, Takahara M, Nagy N, Klein G, Klein E (2006) Cytokine mediated induction of the major Epstein-Barr virus (EBV)-encoded transforming protein, LMP-1. Immunol Lett 104:83\u201388","journal-title":"Immunol Lett"},{"key":"8_CR113","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1073\/pnas.0912920107","volume":"107","author":"LL Kis","year":"2010","unstructured":"Kis LL, Salamon D, Persson EK, Nagy N, Scheeren FA, Spits H, Klein G, Klein E (2010) IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter. Proc Natl Acad Sci USA 107:872\u2013877","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR114","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.immuni.2011.03.025","volume":"34","author":"M Kitano","year":"2011","unstructured":"Kitano M, Moriyama S, Ando Y, Hikida M, Mori Y, Kurosaki T, Okada T (2011) Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34:961\u2013972","journal-title":"Immunity"},{"key":"8_CR115","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0092-8674(83)90449-X","volume":"32","author":"G Klein","year":"1983","unstructured":"Klein G (1983) Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men. Cell 32:311\u2013315","journal-title":"Cell"},{"key":"8_CR116","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/BF03401587","volume":"1","author":"U Klein","year":"1995","unstructured":"Klein U, Klein G, Ehlin-Henriksson B, Rajewsky K, Kuppers R (1995) Burkitt\u2019s lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes. Mol Med 1:495\u2013505","journal-title":"Mol Med"},{"key":"8_CR117","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1084\/jem.188.9.1679","volume":"188","author":"U Klein","year":"1998","unstructured":"Klein U, Rajewsky K, Kuppers R (1998) Human immunoglobulin (Ig)M+IgD+\u00a0peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 188:1679\u20131689","journal-title":"J Exp Med"},{"key":"8_CR118","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1128\/JVI.77.7.4261-4272.2003","volume":"77","author":"JS Knight","year":"2003","unstructured":"Knight JS, Lan K, Subramanian C, Robertson ES (2003) Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines. J Virol 77:4261\u20134272","journal-title":"J Virol"},{"key":"8_CR119","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1182\/blood.V85.2.552.552","volume":"85","author":"DM Knowles","year":"1995","unstructured":"Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE (1995) Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood 85:552\u2013565","journal-title":"Blood"},{"key":"8_CR120","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1084\/jem.192.8.1183","volume":"192","author":"AL Kovalchuk","year":"2000","unstructured":"Kovalchuk AL, Qi CF, Torrey TA, Taddesse-Heath L, Feigenbaum L, Park SS, Gerbitz A, Klobeck G, Hoertnagel K, Polack A, Bornkamm GW, Janz S, III Morse HC (2000) Burkitt lymphoma in the mouse. J Exp Med 192:1183\u20131190","journal-title":"J Exp Med"},{"key":"8_CR121","doi-asserted-by":"publisher","first-page":"11963","DOI":"10.1073\/pnas.95.20.11963","volume":"95","author":"W Kulwichit","year":"1998","unstructured":"Kulwichit W, Edwards RH, Davenport EM, Baskar JF, Godfrey V, Raab-Traub N (1998) Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. Proc Natl Acad Sci USA 95:11963\u201311968","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR122","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1182\/asheducation.V2012.1.328.3798326","volume":"2012","author":"R Kuppers","year":"2012","unstructured":"Kuppers R (2012) New insights in the biology of Hodgkin lymphoma. Hematology Am Soc Hematol Educ Program 2012:328\u2013334","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"8_CR123","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1146\/annurev.immunol.16.1.471","volume":"16","author":"R Kuppers","year":"1998","unstructured":"Kuppers R, Rajewsky K (1998) The origin of Hodgkin and Reed\/Sternberg cells in Hodgkin\u2019s disease. Annu Rev Immunol 16:471\u2013493","journal-title":"Annu Rev Immunol"},{"key":"8_CR124","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1146\/annurev.immunol.17.1.555","volume":"17","author":"T Kurosaki","year":"1999","unstructured":"Kurosaki T (1999) Genetic analysis of B cell antigen receptor signaling. Annu Rev Immunol 17:555\u2013592","journal-title":"Annu Rev Immunol"},{"key":"8_CR125","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S1074-7613(00)00048-0","volume":"13","author":"J Kurth","year":"2000","unstructured":"Kurth J, Spieker T, Wustrow J, Strickler GJ, Hansmann LM, Rajewsky K, Kuppers R (2000) EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency. Immunity 13:485\u2013495","journal-title":"Immunity"},{"key":"8_CR126","doi-asserted-by":"publisher","first-page":"4730","DOI":"10.1073\/pnas.2627966100","volume":"100","author":"J Kurth","year":"2003","unstructured":"Kurth J, Hansmann ML, Rajewsky K, Kuppers R (2003) Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction. Proc Natl Acad Sci USA 100:4730\u20134735","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR127","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.coviro.2014.04.003","volume":"7C","author":"M Kuzembayeva","year":"2014","unstructured":"Kuzembayeva M, Hayes M, Sugden B (2014) Multiple functions are mediated by the miRNAs of Epstein-Barr virus. Curr Opin Virol 7C:61\u201365","journal-title":"Curr Opin Virol"},{"key":"8_CR128","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1128\/JVI.79.2.1296-1307.2005","volume":"79","author":"LL Laichalk","year":"2005","unstructured":"Laichalk LL, Thorley-Lawson DA (2005) Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo. J Virol 79:1296\u20131307","journal-title":"J Virol"},{"key":"8_CR129","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S1074-7613(02)00318-7","volume":"16","author":"LL Laichalk","year":"2002","unstructured":"Laichalk LL, Hochberg D, Babcock GJ, Freeman RB, Thorley-Lawson DA (2002) The dispersal of mucosal memory B cells: evidence from persistent EBV infection. Immunity 16:745\u2013754","journal-title":"Immunity"},{"key":"8_CR130","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0898-6568(02)00083-9","volume":"15","author":"N Lam","year":"2003","unstructured":"Lam N, Sugden B (2003) CD40 and its viral mimic, LMP1: similar means to different ends. Cell Signal 15:9\u201316","journal-title":"Cell Signal"},{"key":"8_CR131","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/S0092-8674(00)80373-6","volume":"90","author":"KP Lam","year":"1997","unstructured":"Lam KP, Kuhn R, Rajewsky K (1997) In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90:1073\u20131083","journal-title":"Cell"},{"key":"8_CR132","unstructured":"Leder P (1985) Translocations among antibody genes in human cancer. In: Lenoir GM, O\u2019conor GT, Olweny CLM (eds) Burkitt\u2019s Lymphomaa human cancer model. Oxford University Press, New York"},{"key":"8_CR133","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/375685a0","volume":"375","author":"J Levitskaya","year":"1995","unstructured":"Levitskaya J, Coram M, Levitsky V, Imreh S, Steigerwald MP, Klein G, Kurilla MG, Masucci MG (1995) Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 375:685\u2013688","journal-title":"Nature"},{"key":"8_CR134","doi-asserted-by":"publisher","first-page":"12616","DOI":"10.1073\/pnas.94.23.12616","volume":"94","author":"J Levitskaya","year":"1997","unstructured":"Levitskaya J, Sharipo A, Leonchiks A, Ciechanover A, Masucci MG (1997) Inhibition of ubiquitin\/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci USA 94:12616\u201312621","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR135","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1128\/jvi.71.6.4657-4662.1997","volume":"71","author":"Q Li","year":"1997","unstructured":"Li Q, Spriggs MK, Kovats S, Turk SM, Comeau MR, Nepom B, Hutt-Fletcher LM (1997) Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes. J Virol 71:4657\u20134662","journal-title":"J Virol"},{"key":"8_CR136","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1600-065X.1997.tb00963.x","volume":"156","author":"YJ Liu","year":"1997","unstructured":"Liu YJ, Arpin C (1997) Germinal center development. Immunol Rev 156:111\u2013126","journal-title":"Immunol Rev"},{"key":"8_CR137","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00271872","volume":"9","author":"M Lotz","year":"1989","unstructured":"Lotz M, Roudier J (1989) Epstein-Barr virus and rheumatoid arthritis: cellular and molecular aspects. Rheumatol Int 9:147\u2013152","journal-title":"Rheumatol Int"},{"key":"8_CR138","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1172\/JCI25720","volume":"116","author":"CS Ma","year":"2006","unstructured":"Ma CS, Pittaluga S, Avery DT, Hare NJ, Maric I, Klion AD, Nichols KE, Tangye SG (2006) Selective generation of functional somatically mutated IgM+\u00a0CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease. J Clin Invest 116:322\u2013333","journal-title":"J Clin Invest"},{"key":"8_CR139","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1182\/blood-2004-09-3740","volume":"105","author":"DC Macallan","year":"2005","unstructured":"Macallan DC, Wallace DL, Zhang Y, Ghattas H, Asquith B, de Lara C, Worth A, Panayiotakopoulos G, Griffin GE, Tough DF, Beverley PC (2005) B-cell kinetics in humans: rapid turnover of peripheral blood memory cells. Blood 105:3633\u20133640","journal-title":"Blood"},{"key":"8_CR140","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nri2572","volume":"9","author":"F Mackay","year":"2009","unstructured":"Mackay F, Schneider P (2009) Cracking the BAFF code. Nat Rev Immunol 9:491\u2013502","journal-title":"Nat Rev Immunol"},{"key":"8_CR141","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1146\/annurev.iy.12.040194.001001","volume":"12","author":"IC Maclennan","year":"1994","unstructured":"Maclennan IC (1994) Germinal centers. Annu Rev Immunol 12:117\u2013139","journal-title":"Annu Rev Immunol"},{"key":"8_CR142","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0952-7915(98)80252-5","volume":"10","author":"IC Maclennan","year":"1998","unstructured":"Maclennan IC (1998) B-cell receptor regulation of peripheral B cells. Curr Opin Immunol 10:220\u2013225","journal-title":"Curr Opin Immunol"},{"key":"8_CR143","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.1182\/blood-2007-05-090142","volume":"110","author":"C Mancao","year":"2007","unstructured":"Mancao C, Hammerschmidt W (2007) Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival. Blood 110:3715\u20133721","journal-title":"Blood"},{"key":"8_CR144","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/237033a0","volume":"237","author":"G Manolov","year":"1972","unstructured":"Manolov G, Manolova Y (1972) Marker band in one chromosome 14 from Burkitt lymphomas. Nature 237:33\u201334","journal-title":"Nature"},{"key":"8_CR145","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1084\/jem.183.3.971","volume":"183","author":"H Martinez-Valdez","year":"1996","unstructured":"Martinez-Valdez H, Guret C, de Bouteiller O, Fugier I, Banchereau J, Liu YJ (1996) Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J Exp Med 183:971\u2013977","journal-title":"J Exp Med"},{"key":"8_CR146","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/35036600","volume":"407","author":"M Maruyama","year":"2000","unstructured":"Maruyama M, Lam KP, Rajewsky K (2000) Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407:636\u2013642","journal-title":"Nature"},{"key":"8_CR147","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1084\/jem.178.4.1407","volume":"178","author":"AK Matsumoto","year":"1993","unstructured":"Matsumoto AK, Martin DR, Carter RH, Klickstein LB, Ahearn JM, Fearon DT (1993) Functional dissection of the CD21\/CD19\/TAPA-1\/Leu-13 complex of B lymphocytes. J Exp Med 178:1407\u20131417","journal-title":"J Exp Med"},{"key":"8_CR148","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S1074-7613(95)80040-9","volume":"2","author":"CL Miller","year":"1995","unstructured":"Miller CL, Burkhardt AL, Lee JH, Stealey B, Longnecker R, Bolen JB, Kieff E (1995) Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity 2:155\u2013166","journal-title":"Immunity"},{"key":"8_CR149","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/0092-8674(95)90513-8","volume":"80","author":"EM Miyashita","year":"1995","unstructured":"Miyashita EM, Yang B, Lam KM, Crawford DH, Thorley-Lawson DA (1995) A novel form of Epstein-Barr virus latency in normal B cells in vivo. Cell 80:593\u2013601","journal-title":"Cell"},{"key":"8_CR150","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1128\/jvi.71.7.4882-4891.1997","volume":"71","author":"EM Miyashita","year":"1997","unstructured":"Miyashita EM, Yang B, Babcock GJ, Thorley-Lawson DA (1997) Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell. J Virol 71:4882\u20134891","journal-title":"J Virol"},{"key":"8_CR151","first-page":"359","volume":"182","author":"R Moorthy","year":"1992","unstructured":"Moorthy R, Thorley-Lawson DA (1992) Mutational analysis of the transforming function of the EBV encoded LMP-1. Curr Top Microbiol Immunol 182:359\u2013365","journal-title":"Curr Top Microbiol Immunol"},{"key":"8_CR152","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0092-8674(95)90489-1","volume":"80","author":"G Mosialos","year":"1995","unstructured":"Mosialos G, Birkenbach M, Yalamanchili R, Vanarsdale T, Ware C, Kieff E (1995) The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80:389\u2013399","journal-title":"Cell"},{"key":"8_CR153","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2776(06)94001-2","volume":"94","author":"M Muramatsu","year":"2007","unstructured":"Muramatsu M, Nagaoka H, Shinkura R, Begum NA, Honjo T (2007) Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Adv Immunol 94:1\u201336","journal-title":"Adv Immunol"},{"key":"8_CR154","doi-asserted-by":"publisher","first-page":"4252","DOI":"10.1038\/sj.emboj.7601853","volume":"26","author":"A Nanbo","year":"2007","unstructured":"Nanbo A, Sugden A, Sugden B (2007) The coupling of synthesis and partitioning of EBV\u2019s plasmid replicon is revealed in live cells. EMBO J 26:4252\u20134262","journal-title":"EMBO J"},{"key":"8_CR155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/jvi.55.2.347-351.1985","volume":"55","author":"GR Nemerow","year":"1985","unstructured":"Nemerow GR, Wolfert R, McNaughton ME, Cooper NR (1985) Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2). J Virol 55:347\u2013351","journal-title":"J Virol"},{"key":"8_CR156","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/sj.onc.1201187","volume":"15","author":"LJ Nicholson","year":"1997","unstructured":"Nicholson LJ, Hopwood P, Johannessen I, Salisbury JR, Codd J, Thorley-Lawson D, Crawford DH (1997) Epstein-Barr virus latent membrane protein does not inhibit differentiation and induces tumorigenicity of human epithelial cells. Oncogene 15:275\u2013283","journal-title":"Oncogene"},{"key":"8_CR157","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1182\/blood.V90.4.1664","volume":"90","author":"G Niedobitek","year":"1997","unstructured":"Niedobitek G, Kremmer E, Herbst H, Whitehead L, Dawson CW, Niedobitek E, von Ostau C, Rooney N, Grasser FA, Young LS (1997) Immunohistochemical detection of the Epstein-Barr virus-encoded latent membrane protein 2A in Hodgkin\u2019s disease and infectious mononucleosis. Blood 90:1664\u20131672","journal-title":"Blood"},{"key":"8_CR158","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/mp.53.1.37","volume":"53","author":"G Niedobitek","year":"2000","unstructured":"Niedobitek G, Agathanggelou A, Steven N, Young LS (2000) Epstein-Barr virus (EBV) in infectious mononucleosis: detection of the virus in tonsillar B lymphocytes but not in desquamated oropharyngeal epithelial cells. Mol Pathol 53:37\u201342","journal-title":"Mol Pathol"},{"key":"8_CR159","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.chom.2010.11.004","volume":"8","author":"PA Nikitin","year":"2010","unstructured":"Nikitin PA, Yan CM, Forte E, Bocedi A, Tourigny JP, White RE, Allday MJ, Patel A, Dave SS, Kim W, Hu K, Guo J, Tainter D, Rusyn E, Luftig MA (2010) An ATM\/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. Cell Host Microbe 8:510\u2013522","journal-title":"Cell Host Microbe"},{"key":"8_CR160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-3-642-67236-1_11","volume-title":"The Epstein-Barr Virus","author":"K. Nilsson","year":"1979","unstructured":"Nilsson K (1979) The nature of lymphoid cell lines and their relationship to the virus. In: Epstein MA, Achong BG (eds) The Epstein-Barr virus. Springer, Berlin"},{"key":"8_CR161","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1128\/jvi.70.1.623-627.1996","volume":"70","author":"C Nonkwelo","year":"1996","unstructured":"Nonkwelo C, Skinner J, Bell A, Rickinson A, Sample J (1996) Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein. J Virol 70:623\u2013627","journal-title":"J Virol"},{"key":"8_CR162","doi-asserted-by":"publisher","first-page":"7181","DOI":"10.1038\/sj.onc.1206838","volume":"22","author":"J O\u2019Nions","year":"2003","unstructured":"O\u2019Nions J, Allday MJ (2003) Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2. Oncogene 22:7181\u20137191","journal-title":"Oncogene"},{"key":"8_CR163","first-page":"119","volume-title":"Advances in Cancer Research","author":"Jenny O'Nions","year":"2004","unstructured":"O\u2019nions J, Allday MJ (2004) Deregulation of the Cell Cycle by the Epstein-Barr Virus. In: Vande Woude GF, Klein G (eds) Advances in Cancer Research. Elsevier, New York"},{"key":"8_CR164","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1136\/jcp.49.11.897","volume":"49","author":"JJ Oudejans","year":"1996","unstructured":"Oudejans JJ, Dukers DF, Jiwa NM, van den Brule AJ, Grasser FA, de Bruin PC, Horstman A, Vos W, van Gorp J, Middeldorp JM, Meijer CJ (1996) Expression of epstein-barr virus encoded nuclear antigen 1 in benign and malignant tissues harbouring EBV. J Clin Pathol 49:897\u2013902","journal-title":"J Clin Pathol"},{"key":"8_CR165","doi-asserted-by":"publisher","first-page":"13253","DOI":"10.1128\/JVI.78.23.13253-13261.2004","volume":"78","author":"D Panagopoulos","year":"2004","unstructured":"Panagopoulos D, Victoratos P, Alexiou M, Kollias G, Mosialos G (2004) Comparative analysis of signal transduction by CD40 and the Epstein-Barr virus oncoprotein LMP1 in vivo. J Virol 78:13253\u201313261","journal-title":"J Virol"},{"key":"8_CR166","first-page":"2541","volume":"13","author":"GA Parker","year":"1996","unstructured":"Parker GA, Crook T, Bain M, Sara EA, Farrell PJ, Allday MJ (1996) Epstein-Barr virus nuclear antigen (EBNA)3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7. Oncogene 13:2541\u20132549","journal-title":"Oncogene"},{"key":"8_CR167","doi-asserted-by":"publisher","first-page":"12613","DOI":"10.1128\/JVI.78.22.12613-12624.2004","volume":"78","author":"DM Pegtel","year":"2004","unstructured":"Pegtel DM, Middeldorp J, Thorley-Lawson DA (2004) Epstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriers. J Virol 78:12613\u201312624","journal-title":"J Virol"},{"key":"8_CR168","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/BF00838048","volume":"20","author":"I Penn","year":"1998","unstructured":"Penn I (1998) The role of immunosuppression in lymphoma formation. Springer Semin Immunopathol 20:343\u2013355","journal-title":"Springer Semin Immunopathol"},{"issue":"Pt 1","key":"8_CR169","first-page":"111","volume":"185","author":"ME Perry","year":"1994","unstructured":"Perry ME (1994) The specialised structure of crypt epithelium in the human palatine tonsil and its functional significance. J Anat 185(Pt 1):111\u2013127","journal-title":"J Anat"},{"key":"8_CR170","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/S0167-5699(98)01307-3","volume":"19","author":"M Perry","year":"1998","unstructured":"Perry M, Whyte A (1998) Immunology of the tonsils. Immunol Today 19:414\u2013421","journal-title":"Immunol Today"},{"key":"8_CR171","doi-asserted-by":"publisher","first-page":"10411","DOI":"10.1073\/pnas.93.19.10411","volume":"93","author":"A Polack","year":"1996","unstructured":"Polack A, Hortnagel K, Pajic A, Christoph B, Baier B, Falk M, Mautner J, Geltinger C, Bornkamm GW, Kempkes B (1996) c-myc activation renders proliferation of Epstein-Barr virus (EBV)- transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1. Proc Natl Acad Sci U S A 93:10411\u201310416","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR172","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/ijc.2910030619","volume":"3","author":"JH Pope","year":"1968","unstructured":"Pope JH, Horne MK, Scott W (1968) Transformation of foetal human keukocytes in vitro by filtrates of a human leukaemic cell line containing herpes-like virus. Int J Cancer 3:857\u2013866","journal-title":"Int J Cancer"},{"key":"8_CR173","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/B978-0-12-800098-4.00006-4","volume":"88","author":"AM Price","year":"2014","unstructured":"Price AM, Luftig MA (2014) Dynamic Epstein-Barr virus gene expression on the path to B-cell transformation. Adv Virus Res 88:279\u2013313","journal-title":"Adv Virus Res"},{"key":"8_CR174","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/S0140-6736(75)92004-8","volume":"1","author":"DT Purtilo","year":"1975","unstructured":"Purtilo DT, Cassel CK, Yang JP, Harper R (1975) X-linked recessive progressive combined variable immunodeficiency (Duncan\u2019s disease). Lancet 1:935\u2013940","journal-title":"Lancet"},{"key":"8_CR175","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1128\/jvi.66.6.3715-3724.1992","volume":"66","author":"L Qu","year":"1992","unstructured":"Qu L, Rowe DT (1992) Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes. J Virol 66:3715\u20133724","journal-title":"J Virol"},{"key":"8_CR176","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1002\/eji.200636746","volume":"37","author":"MF Quigley","year":"2007","unstructured":"Quigley MF, Gonzalez VD, Granath A, Andersson J, Sandberg JK (2007) CXCR5+\u00a0CCR7\u2212 CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. Eur J Immunol 37:3352\u20133362","journal-title":"Eur J Immunol"},{"key":"8_CR177","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S1044579X0200086X","volume":"12","author":"N Raab-Traub","year":"2002","unstructured":"Raab-Traub N (2002) Epstein-Barr virus in the pathogenesis of NPC. Semin Cancer Biol 12:431\u2013441","journal-title":"Semin Cancer Biol"},{"key":"8_CR178","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0092-8674(80)90173-7","volume":"22","author":"N Raab-Traub","year":"1980","unstructured":"Raab-Traub N, Dambaugh T, Kieff E (1980) DNA of Epstein-Barr virus VIII: B95-8, the previous prototype, is an unusual deletion derivative. Cell 22:257\u2013267","journal-title":"Cell"},{"key":"8_CR179","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1128\/jvi.65.12.7032-7036.1991","volume":"65","author":"N Raab-Traub","year":"1991","unstructured":"Raab-Traub N, Rajadurai P, Flynn K, Lanier AP (1991) Epstein-Barr virus infection in carcinoma of the salivary gland. J Virol 65:7032\u20137036","journal-title":"J Virol"},{"key":"8_CR180","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1128\/JVI.73.7.5688-5697.1999","volume":"73","author":"SA Radkov","year":"1999","unstructured":"Radkov SA, Touitou R, Brehm A, Rowe M, West M, Kouzarides T, Allday MJ (1999) Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription. J Virol 73:5688\u20135697","journal-title":"J Virol"},{"key":"8_CR181","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.cell.2004.08.006","volume":"118","author":"AR Ramiro","year":"2004","unstructured":"Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC (2004) AID is required for c-myc\/IgH chromosome translocations in vivo. Cell 118:431\u2013438","journal-title":"Cell"},{"key":"8_CR182","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1128\/JVI.03378-13","volume":"88","author":"N Renzette","year":"2014","unstructured":"Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K (2014) Epstein-Barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids. J Virol 88:3744\u20133755","journal-title":"J Virol"},{"key":"8_CR183","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.semcancer.2008.10.008","volume":"18","author":"ME Ressing","year":"2008","unstructured":"Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ (2008) Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products. Semin Cancer Biol 18:397\u2013408","journal-title":"Semin Cancer Biol"},{"key":"8_CR184","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1002\/ijc.2910200607","volume":"20","author":"AB Rickinson","year":"1977","unstructured":"Rickinson AB, Finerty S, Epstein MA (1977) Mechanism of the establishment of Epstein-Barr virus genome-containing lymphoid cell lines from infectious mononucleosis patients: studies with phosphonoacetate. Int J Cancer 20:861\u2013868","journal-title":"Int J Cancer"},{"key":"8_CR185","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.cell.2008.09.062","volume":"135","author":"DF Robbiani","year":"2008","unstructured":"Robbiani DF, Bothmer A, Callen E, Reina-San-martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC (2008) AID is required for the chromosomal breaks in c-myc that lead to c-myc\/IgH translocations. Cell 135:1028\u20131038","journal-title":"Cell"},{"key":"8_CR186","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1128\/jvi.63.4.1531-1539.1989","volume":"63","author":"C Rooney","year":"1989","unstructured":"Rooney C, Howe JG, Speck SH, Miller G (1989) Influence of Burkitt\u2019s lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus. J Virol 63:1531\u20131539","journal-title":"J Virol"},{"key":"8_CR187","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0140-6736(95)91150-2","volume":"345","author":"CM Rooney","year":"1995","unstructured":"Rooney CM, Smith CA, Ng CY, Loftin S, Li C, Krance RA, Brenner MK, Heslop HE (1995) Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 345:9\u201313","journal-title":"Lancet"},{"key":"8_CR188","doi-asserted-by":"publisher","first-page":"3968","DOI":"10.1128\/JVI.02609-08","volume":"83","author":"JE Roughan","year":"2009","unstructured":"Roughan JE, Thorley-Lawson DA (2009) The intersection of Epstein-Barr virus with the germinal center. J Virol 83:3968\u20133976","journal-title":"J Virol"},{"key":"8_CR189","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1128\/JVI.01780-09","volume":"84","author":"JE Roughan","year":"2010","unstructured":"Roughan JE, Torgbor C, Thorley-Lawson DA (2010) Germinal center B cells latently infected with Epstein-Barr virus proliferate extensively but do not increase in number. J Virol 84:1158\u20131168","journal-title":"J Virol"},{"key":"8_CR190","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1128\/JVI.06829-11","volume":"86","author":"D Salamon","year":"2012","unstructured":"Salamon D, Adori M, Ujvari D, Wu L, Kis LL, Madapura HS, Nagy N, Klein G, Klein E (2012) Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells. J Virol 86:4701\u20134707","journal-title":"J Virol"},{"key":"8_CR191","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/26683","volume":"395","author":"J Sayos","year":"1998","unstructured":"Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, de Vries JE, Aversa G, Terhorst C (1998) The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395:462\u2013469","journal-title":"Nature"},{"key":"8_CR192","doi-asserted-by":"publisher","first-page":"10565","DOI":"10.1073\/pnas.92.23.10565","volume":"92","author":"BC Schaefer","year":"1995","unstructured":"Schaefer BC, Strominger JL, Speck SH (1995) Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines. Proc Natl Acad Sci USA 92:10565\u201310569","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR193","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1084\/jem.20102477","volume":"208","author":"TA Schwickert","year":"2011","unstructured":"Schwickert TA, Victora GD, Fooksman DR, Kamphorst AO, Mugnier MR, Gitlin AD, Dustin ML, Nussenzweig MC (2011) A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med 208:1243\u20131252","journal-title":"J Exp Med"},{"key":"8_CR194","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1203\/00006450-199510000-00001","volume":"38","author":"TA Seemayer","year":"1995","unstructured":"Seemayer TA, Gross TG, Egeler RM, Pirruccello SJ, Davis JR, Kelly CM, Okano M, Lanyi A, Sumegi J (1995) X-linked lymphoproliferative disease: twenty-five years after the discovery. Pediatr Res 38:471\u2013478","journal-title":"Pediatr Res"},{"key":"8_CR195","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1084\/jem.188.9.1705","volume":"188","author":"LK Selin","year":"1998","unstructured":"Selin LK, Varga SM, Wong IC, Welsh RM (1998) Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J Exp Med 188:1705\u20131715","journal-title":"J Exp Med"},{"key":"8_CR196","first-page":"769","volume":"140","author":"D Shibata","year":"1992","unstructured":"Shibata D, Weiss LM (1992) Epstein-Barr virus-associated gastric adenocarcinoma. Am J Pathol 140:769\u2013774","journal-title":"Am J Pathol"},{"key":"8_CR197","first-page":"469","volume":"139","author":"D Shibata","year":"1991","unstructured":"Shibata D, Tokunaga M, Uemura Y, Sato E, Tanaka S, Weiss LM (1991) Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma. Am J Pathol 139:469\u2013474","journal-title":"Am J Pathol"},{"key":"8_CR198","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1016\/j.molimm.2008.03.002","volume":"45","author":"D Siemer","year":"2008","unstructured":"Siemer D, Kurth J, Lang S, Lehnerdt G, Stanelle J, Kuppers R (2008) EBV transformation overrides gene expression patterns of B cell differentiation stages. Mol Immunol 45:3133\u20133141","journal-title":"Mol Immunol"},{"key":"8_CR199","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1128\/jvi.69.9.5461-5468.1995","volume":"69","author":"AJ Sinclair","year":"1995","unstructured":"Sinclair AJ, Farrell PJ (1995) Host cell requirements for efficient infection of quiescent primary B lymphocytes by Epstein-Barr virus. J Virol 69:5461\u20135468","journal-title":"J Virol"},{"key":"8_CR200","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1002\/j.1460-2075.1994.tb06634.x","volume":"13","author":"AJ Sinclair","year":"1994","unstructured":"Sinclair AJ, Palmero I, Peters G, Farrell PJ (1994) EBNA-2 and EBNA-LP cooperate to cause G0 to G1 transition during immortalization of resting human B lymphocytes by Epstein-Barr virus. EMBO J 13:3321\u20133328","journal-title":"EMBO J"},{"key":"8_CR201","doi-asserted-by":"publisher","first-page":"e1002484","DOI":"10.1371\/journal.ppat.1002484","volume":"8","author":"RL Skalsky","year":"2012","unstructured":"Skalsky RL, Corcoran DL, Gottwein E, Frank CL, Kang D, Hafner M, Nusbaum JD, Feederle R, Delecluse HJ, Luftig MA, Tuschl T, Ohler U, Cullen BR (2012) The viral and cellular microRNA targetome in lymphoblastoid cell lines. PLoS Pathog 8:e1002484","journal-title":"PLoS Pathog"},{"key":"8_CR202","doi-asserted-by":"publisher","first-page":"18093","DOI":"10.1073\/pnas.0509311102","volume":"102","author":"TA Souza","year":"2005","unstructured":"Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA (2005) Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells. Proc Natl Acad Sci USA 102:18093\u201318098","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR203","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.4049\/jimmunol.179.5.3153","volume":"179","author":"TA Souza","year":"2007","unstructured":"Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA (2007) Influence of EBV on the peripheral blood memory B cell compartment. J Immunol 179:3153\u20133160","journal-title":"J Immunol"},{"key":"8_CR204","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/nm1002-1086","volume":"8","author":"SH Speck","year":"2002","unstructured":"Speck SH (2002) EBV framed in Burkitt lymphoma. Nat Med 8:1086\u20131087","journal-title":"Nat Med"},{"key":"8_CR205","first-page":"607","volume":"62","author":"J Spencer","year":"1985","unstructured":"Spencer J, Finn T, Pulford KA, Mason DY, Isaacson PG (1985) The human gut contains a novel population of B lymphocytes which resemble marginal zone cells. Clin Exp Immunol 62:607\u2013612","journal-title":"Clin Exp Immunol"},{"key":"8_CR206","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0167-5699(98)01308-5","volume":"19","author":"J Spencer","year":"1998","unstructured":"Spencer J, Perry ME, Dunn-Walters DK (1998) Human marginal-zone B cells. Immunol Today 19:421\u2013426","journal-title":"Immunol Today"},{"key":"8_CR207","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.coi.2008.03.015","volume":"20","author":"JE Stadanlick","year":"2008","unstructured":"Stadanlick JE, Cancro MP (2008) BAFF and the plasticity of peripheral B cell tolerance. Curr Opin Immunol 20:158\u2013161","journal-title":"Curr Opin Immunol"},{"key":"8_CR208","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0140-6736(84)90994-2","volume":"1","author":"TE Starzl","year":"1984","unstructured":"Starzl TE, Nalesnik MA, Porter KA, Ho M, Iwatsuki S, Griffith BP, Rosenthal JT, Hakala TR, Jr Shaw BW, Hardesty RL et al (1984) Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1:583\u2013587","journal-title":"Lancet"},{"key":"8_CR209","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1084\/jem.184.5.1801","volume":"184","author":"NM Steven","year":"1996","unstructured":"Steven NM, Leese AM, Annels NE, Lee SP, Rickinson AB (1996) Epitope focusing in the primary cytotoxic T cell response to Epstein-Barr virus and its relationship to T cell memory. J Exp Med 184:1801\u20131813","journal-title":"J Exp Med"},{"key":"8_CR210","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1002\/eji.1830170717","volume":"17","author":"G Strang","year":"1987","unstructured":"Strang G, Rickinson AB (1987) Multiple HLA class I-dependent cytotoxicities constitute the \u201cnon-HLA-restricted\u201d response in infectious mononucleosis. Eur J Immunol 17:1007\u20131013","journal-title":"Eur J Immunol"},{"key":"8_CR211","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1006\/viro.1999.9619","volume":"256","author":"Y Sugawara","year":"1999","unstructured":"Sugawara Y, Mizugaki Y, Uchida T, Torii T, Imai S, Makuuchi M, Takada K (1999) Detection of Epstein-Barr virus (EBV) in hepatocellular carcinoma tissue: a novel EBV latency characterized by the absence of EBV-encoded small RNA expression. Virology 256:196\u2013202","journal-title":"Virology"},{"key":"8_CR212","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.it.2007.03.002","volume":"28","author":"M Swanson-Mungerson","year":"2007","unstructured":"Swanson-Mungerson M, Longnecker R (2007) Epstein-Barr virus latent membrane protein 2A and autoimmunity. Trends Immunol 28:213\u2013218","journal-title":"Trends Immunol"},{"key":"8_CR213","doi-asserted-by":"publisher","first-page":"7355","DOI":"10.1128\/JVI.79.12.7355-7362.2005","volume":"79","author":"MA Swanson-Mungerson","year":"2005","unstructured":"Swanson-Mungerson MA, Caldwell RG, Bultema R, Longnecker R (2005) Epstein-Barr virus LMP2A alters in vivo and in vitro models of B-cell anergy, but not deletion, in response to autoantigen. J Virol 79:7355\u20137362","journal-title":"J Virol"},{"key":"8_CR214","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1440-1827.1995.tb03377.x","volume":"45","author":"X Tang","year":"1995","unstructured":"Tang X, Hori S, Osamura RY, Tsutsumi Y (1995) Reticular crypt epithelium and intra-epithelial lymphoid cells in the hyperplastic human palatine tonsil: an immunohistochemical analysis. Pathol Int 45:34\u201344","journal-title":"Pathol Int"},{"key":"8_CR215","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/ijc.2910600306","volume":"60","author":"Q Tao","year":"1995","unstructured":"Tao Q, Ho FC, Loke SL, Srivastava G (1995) Epstein-Barr virus is localized in the tumour cells of nasal lymphomas of NK, T or B cell type. Int J Cancer 60:315\u2013320","journal-title":"Int J Cancer"},{"key":"8_CR216","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1097\/00007890-199005000-00022","volume":"49","author":"JA Thomas","year":"1990","unstructured":"Thomas JA, Hotchin NA, Allday MJ, Amlot P, Rose M, Yacoub M, Crawford DH (1990) Immunohistology of Epstein-Barr virus-associated antigens in B cell disorders from immunocompromised individuals. Transplantation 49:944\u2013953","journal-title":"Transplantation"},{"key":"8_CR217","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/35095584","volume":"1","author":"DA Thorley-Lawson","year":"2001","unstructured":"Thorley-Lawson DA (2001) Epstein-Barr virus: exploiting the immune system. Nat Rev Immunol 1:75\u201382","journal-title":"Nat Rev Immunol"},{"key":"8_CR218","volume-title":"Epstein-Barr Virus","author":"DA Thorley-Lawson","year":"2005","unstructured":"Thorley-Lawson DA (2005) EBV persistence and latent infection in vivo. In: Robertson ES (ed) Epstein-Barr Virus. Caister Academic Press, Norfolk"},{"key":"8_CR219","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/nrmicro2015","volume":"6","author":"DA Thorley-Lawson","year":"2008","unstructured":"Thorley-Lawson DA, Allday MJ (2008) The curious case of the tumour virus: 50\u00a0years of Burkitt\u2019s lymphoma. Nat Rev Microbiol 6:913\u2013924","journal-title":"Nat Rev Microbiol"},{"key":"8_CR220","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/S0024-3205(99)00214-3","volume":"65","author":"DA Thorley-Lawson","year":"1999","unstructured":"Thorley-Lawson DA, Babcock GJ (1999) A model for persistent infection with Epstein-Barr virus: the stealth virus of human B cells. Life Sci 65:1433\u20131453","journal-title":"Life Sci"},{"key":"8_CR221","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1056\/NEJMra032015","volume":"350","author":"DA Thorley-Lawson","year":"2004","unstructured":"Thorley-Lawson DA, Gross A (2004) Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Engl J Med 350:1328\u20131337","journal-title":"N Engl J Med"},{"key":"8_CR222","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1084\/jem.162.1.45","volume":"162","author":"DA Thorley-Lawson","year":"1985","unstructured":"Thorley-Lawson DA, Mann KP (1985) Early events in Epstein-Barr virus infection provide a model for B cell activation. J Exp Med 162:45\u201359","journal-title":"J Exp Med"},{"key":"8_CR223","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1128\/jvi.43.2.730-736.1982","volume":"43","author":"DA Thorley-Lawson","year":"1982","unstructured":"Thorley-Lawson DA, Poodry CA (1982) Identification and isolation of the main component (gp350\u2013gp220) of Epstein-Barr virus responsible for generating neutralizing antibodies in vivo. J Virol 43:730\u2013736","journal-title":"J Virol"},{"key":"8_CR224","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0042-6822(78)90082-X","volume":"86","author":"DA Thorley-Lawson","year":"1978","unstructured":"Thorley-Lawson DA, Strominger JL (1978) Reversible inhibition by phosphonoacetic acid of human B lymphocyte transformation by Epstein-Barr virus. Virology 86:423\u2013431","journal-title":"Virology"},{"key":"8_CR225","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0092-8674(82)90239-2","volume":"30","author":"DA Thorley-Lawson","year":"1982","unstructured":"Thorley-Lawson DA, Schooley RT, Bhan AK, Nadler LM (1982) Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts. Cell 30:415\u2013425","journal-title":"Cell"},{"key":"8_CR226","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.4049\/jimmunol.134.5.3007","volume":"134","author":"DA Thorley-Lawson","year":"1985","unstructured":"Thorley-Lawson DA, Nadler LM, Bhan AK, Schooley RT (1985) BLAST-2 [EBVCS], an early cell surface marker of human B cell activation, is superinduced by Epstein Barr virus. Journal of Immunology 134:3007\u20133012","journal-title":"Journal of Immunology"},{"key":"8_CR227","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.coviro.2013.04.005","volume":"3","author":"DA Thorley-Lawson","year":"2013","unstructured":"Thorley-Lawson DA, Hawkins JB, Tracy SI, Shapiro M (2013) The pathogenesis of Epstein-Barr virus persistent infection. Curr Opin Virol 3:227\u2013232","journal-title":"Curr Opin Virol"},{"key":"8_CR228","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.1128\/jvi.68.11.7374-7385.1994","volume":"68","author":"RJ Tierney","year":"1994","unstructured":"Tierney RJ, Steven N, Young LS, Rickinson AB (1994) Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state. J Virol 68:7374\u20137385","journal-title":"J Virol"},{"key":"8_CR229","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1002\/1097-0142(19951015)76:8<1481::AID-CNCR2820760828>3.0.CO;2-K","volume":"76","author":"CF Timmons","year":"1995","unstructured":"Timmons CF, Dawson DB, Richards CS, Andrews WS, Katz JA (1995) Epstein-Barr virus-associated leiomyosarcomas in liver transplantation recipients. Origin from either donor or recipient tissue. Cancer 76:1481\u20131489","journal-title":"Cancer"},{"key":"8_CR230","doi-asserted-by":"publisher","first-page":"e1004170","DOI":"10.1371\/journal.ppat.1004170","volume":"10","author":"C Torgbor","year":"2014","unstructured":"Torgbor C, Awuah P, Deitsch K, Kalantari P, Duca KA, Thorley-Lawson DA (2014) A multifactorial role for P. falciparum malaria in endemic Burkitt\u2019s lymphoma pathogenesis. PLoS Pathog 10:e1004170","journal-title":"PLoS Pathog"},{"key":"8_CR231","doi-asserted-by":"publisher","first-page":"7749","DOI":"10.1128\/JVI.75.16.7749-7755.2001","volume":"75","author":"R Touitou","year":"2001","unstructured":"Touitou R, Hickabottom M, Parker G, Crook T, Allday MJ (2001) Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C. J Virol 75:7749\u20137755","journal-title":"J Virol"},{"key":"8_CR232","doi-asserted-by":"publisher","first-page":"12330","DOI":"10.1128\/JVI.01699-12","volume":"86","author":"SI Tracy","year":"2012","unstructured":"Tracy SI, Kakalacheva K, Lunemann JD, Luzuriaga K, Middeldorp J, Thorley-Lawson DA (2012) Persistence of Epstein-Barr virus in self-reactive memory B cells. J Virol 86:12330\u201312340","journal-title":"J Virol"},{"key":"8_CR233","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1089\/dna.1995.14.767","volume":"14","author":"CN Tsai","year":"1995","unstructured":"Tsai CN, Liu ST, Chang YS (1995) Identification of a novel promoter located within the Bam HI Q region of the Epstein-Barr virus genome for the EBNA 1 gene. DNA Cell Biol 14:767\u2013776","journal-title":"DNA Cell Biol"},{"key":"8_CR234","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nm830","volume":"9","author":"SM Tugizov","year":"2003","unstructured":"Tugizov SM, Berline JW, Palefsky JM (2003) Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells. Nat Med 9:307\u2013314","journal-title":"Nat Med"},{"key":"8_CR235","doi-asserted-by":"publisher","first-page":"8179","DOI":"10.1128\/JVI.00443-13","volume":"87","author":"SM Tugizov","year":"2013","unstructured":"Tugizov SM, Herrera R, Palefsky JM (2013) Epstein-Barr virus transcytosis through polarized oral epithelial cells. J Virol 87:8179\u20138194","journal-title":"J Virol"},{"key":"8_CR236","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1126\/science.286.5438.300","volume":"286","author":"J Uchida","year":"1999","unstructured":"Uchida J, Yasui T, Takaoka-Shichijo Y, Muraoka M, Kulwichit W, Raab-Traub N, Kikutani H (1999) Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses. Science 286:300\u2013303","journal-title":"Science"},{"key":"8_CR237","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1056\/NEJM199506223322516","volume":"332","author":"T van Gelder","year":"1995","unstructured":"van Gelder T, Vuzevski VD, Weimar W (1995) Epstein-Barr virus in smooth-muscle tumors. N Engl J Med 332:1719","journal-title":"N Engl J Med"},{"key":"8_CR238","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.semcancer.2009.07.006","volume":"19","author":"D Vereide","year":"2009","unstructured":"Vereide D, Sugden B (2009) Proof for EBV\u2019s sustaining role in Burkitt\u2019s lymphomas. Semin Cancer Biol 19:389\u2013393","journal-title":"Semin Cancer Biol"},{"key":"8_CR239","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/onc.2013.71","volume":"33","author":"DT Vereide","year":"2014","unstructured":"Vereide DT, Seto E, Chiu YF, Hayes M, Tagawa T, Grundhoff A, Hammerschmidt W, Sugden B (2014) Epstein-Barr virus maintains lymphomas via its miRNAs. Oncogene 33:1258\u20131264","journal-title":"Oncogene"},{"key":"8_CR240","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","volume":"30","author":"GD Victora","year":"2012","unstructured":"Victora GD, Nussenzweig MC (2012) Germinal centers. Annu Rev Immunol 30:429\u2013457","journal-title":"Annu Rev Immunol"},{"key":"8_CR241","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.cell.2010.10.032","volume":"143","author":"GD Victora","year":"2010","unstructured":"Victora GD, Schwickert TA, Fooksman DR, Kamphorst AO, Meyer-Hermann M, Dustin ML, Nussenzweig MC (2010) Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143:592\u2013605","journal-title":"Cell"},{"key":"8_CR242","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1182\/blood-2012-03-415380","volume":"120","author":"GD Victora","year":"2012","unstructured":"Victora GD, Dominguez-Sola D, Holmes AB, Deroubaix S, Dalla-Favera R, Nussenzweig MC (2012) Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood 120:2240\u20132248","journal-title":"Blood"},{"key":"8_CR243","doi-asserted-by":"publisher","first-page":"e1002662","DOI":"10.1371\/journal.ppat.1002662","volume":"8","author":"AC Vrazo","year":"2012","unstructured":"Vrazo AC, Chauchard M, Raab-Traub N, Longnecker R (2012) Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice. PLoS Pathog 8:e1002662","journal-title":"PLoS Pathog"},{"key":"8_CR244","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1128\/MCB.20.4.1344-1360.2000","volume":"20","author":"M Wade","year":"2000","unstructured":"Wade M, Allday MJ (2000) Epstein-Barr virus suppresses a G(2)\/M checkpoint activated by genotoxins. Mol Cell Biol 20:1344\u20131360","journal-title":"Mol Cell Biol"},{"key":"8_CR245","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.coviro.2013.03.003","volume":"3","author":"F Wang","year":"2013","unstructured":"Wang F (2013) Nonhuman primate models for Epstein-Barr virus infection. Curr Opin Virol 3:233\u2013237","journal-title":"Curr Opin Virol"},{"key":"8_CR246","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/0092-8674(85)90256-9","volume":"43","author":"D Wang","year":"1985","unstructured":"Wang D, Liebowitz D, Kieff E (1985) An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43:831\u2013840","journal-title":"Cell"},{"key":"8_CR247","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.immunol.021908.132607","volume":"27","author":"JC Weill","year":"2009","unstructured":"Weill JC, Weller S, Reynaud CA (2009) Human marginal zone B cells. Annu Rev Immunol 27:267\u2013285","journal-title":"Annu Rev Immunol"},{"key":"8_CR248","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1182\/blood-2004-01-0346","volume":"104","author":"S Weller","year":"2004","unstructured":"Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, Conley ME, Plebani A, Kumararatne DS, Bonnet D, Tournilhac O, Tchernia G, Steiniger B, Staudt LM, Casanova JL, Reynaud CA, Weill JC (2004) Human blood IgM \u201cmemory\u201d B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 104:3647\u20133654","journal-title":"Blood"},{"key":"8_CR249","doi-asserted-by":"publisher","first-page":"e13979","DOI":"10.1371\/journal.pone.0013979","volume":"5","author":"RE White","year":"2010","unstructured":"White RE, Groves IJ, Turro E, Yee J, Kremmer E, Allday MJ (2010) Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification. PLoS ONE 5:e13979","journal-title":"PLoS ONE"},{"key":"8_CR250","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1172\/JCI58092","volume":"122","author":"RE White","year":"2012","unstructured":"White RE, Ramer PC, Naresh KN, Meixlsperger S, Pinaud L, Rooney C, Savoldo B, Coutinho R, Bodor C, Gribben J, Ibrahim HA, Bower M, Nourse JP, Gandhi MK, Middeldorp J, Cader FZ, Murray P, Munz C, Allday MJ (2012) EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J Clin Invest 122:1487\u20131502","journal-title":"J Clin Invest"},{"key":"8_CR251","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1002\/j.1460-2075.1996.tb00674.x","volume":"15","author":"JB Wilson","year":"1996","unstructured":"Wilson JB, Bell JL, Levine AJ (1996) Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. EMBO J 15:3117\u20133126","journal-title":"EMBO J"},{"key":"8_CR252","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1073\/pnas.87.5.1725","volume":"87","author":"M Woisetschlaeger","year":"1990","unstructured":"Woisetschlaeger M, Yandava CN, Furmanski LA, Strominger JL, Speck SH (1990) Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes. Proc Natl Acad Sci USA 87:1725\u20131729","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR253","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/0002-9343(67)90073-3","volume":"42","author":"TA Wood","year":"1967","unstructured":"Wood TA, Frenkel EP (1967) The atypical lymphocyte. Am J Med 42:923\u2013936","journal-title":"Am J Med"},{"key":"8_CR254","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/ni1434","volume":"8","author":"W Xu","year":"2007","unstructured":"Xu W, He B, Chiu A, Chadburn A, Shan M, Buldys M, Ding A, Knowles DM, Santini PA, Cerutti A (2007) Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nat Immunol 8:294\u2013303","journal-title":"Nat Immunol"},{"key":"8_CR255","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/ijc.2910350107","volume":"35","author":"QY Yao","year":"1985","unstructured":"Yao QY, Rickinson AB, Epstein MA (1985) A re-examination of the Epstein-Barr virus carrier state in healthy seropositive individuals. Int J Cancer 35:35\u201342","journal-title":"Int J Cancer"},{"key":"8_CR256","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/313812a0","volume":"313","author":"JL Yates","year":"1985","unstructured":"Yates JL, Warren N, Sugden B (1985) Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature 313:812\u2013815","journal-title":"Nature"},{"key":"8_CR257","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/ng0697-161","volume":"16","author":"BH Ye","year":"1997","unstructured":"Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RS, Rothman P, Stall AM, Pandolfi PP, Dalla-Favera R (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 16:161\u2013170","journal-title":"Nat Genet"},{"key":"8_CR258","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0167-5699(99)01476-0","volume":"20","author":"P Youinou","year":"1999","unstructured":"Youinou P, Jamin C, Lydyard PM (1999) CD5 expression in human B-cell populations. Immunol Today 20:312\u2013316","journal-title":"Immunol Today"},{"key":"8_CR259","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1006\/scbi.2001.0409","volume":"11","author":"U Zimber-Strobl","year":"2001","unstructured":"Zimber-Strobl U, Strobl LJ (2001) EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes. Semin Cancer Biol 11:423\u2013434","journal-title":"Semin Cancer Biol"}],"container-title":["Current Topics in Microbiology and Immunology","Epstein Barr Virus Volume 1"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-22822-8_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T12:59:57Z","timestamp":1676033997000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-319-22822-8_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9783319228211","9783319228228"],"references-count":259,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-22822-8_8","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"1 October 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}