{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:14:03Z","timestamp":1792887243132,"version":"4.5.0"},"publisher-location":"Cham","reference-count":63,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319283814","type":"print"},{"value":"9783319283838","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-3-319-28383-8_12","type":"book-chapter","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T09:03:55Z","timestamp":1474362235000},"page":"229-245","source":"Crossref","is-referenced-by-count":75,"title":["Role of Quercetin Benefits in Neurodegeneration"],"prefix":"10.1007","author":[{"given":"Preetham","family":"Elumalai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreeja","family":"Lakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"12_CR1","first-page":"672838","volume":"2015","author":"ZS Agim","year":"2015","unstructured":"Agim ZS, Cannon JR. Dietary factors in the etiology of Parkinson\u2019s disease. Biomed Res Int. 2015;2015:672838.","journal-title":"Biomed Res Int"},{"key":"12_CR2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jnutbio.2008.03.002","volume":"20","author":"MA Ansari","year":"2009","unstructured":"Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA. Protective effect of quercetin in primary neurons against Abeta (1\u201342): relevance to Alzheimer\u2019s disease. J Nutr Biochem. 2009;20:269\u201375.","journal-title":"J Nutr Biochem"},{"key":"12_CR3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0014-5793(02)02754-0","volume":"520","author":"HM Awad","year":"2002","unstructured":"Awad HM, Boersma MG, Boeren S, van der Woude H, van Zanden J, van Bladeren PJ, Vervoort J, Rietjens IM. Identification of o-quinone\/quinone methide metabolites of quercetin in a cellular in vitro system. FEBS Lett. 2002;520:30\u20134.","journal-title":"FEBS Lett"},{"key":"12_CR4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2741\/S415","volume":"6","author":"JM Beitz","year":"2014","unstructured":"Beitz JM. Parkinson\u2019s disease: a review. Front Biosci (School Ed). 2014;6:65\u201374.","journal-title":"Front Biosci (School Ed)"},{"key":"12_CR5","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.bbrc.2005.10.031","volume":"338","author":"AW Boots","year":"2005","unstructured":"Boots AW, Balk JM, Bast A, Haenen GR. The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity. Biochem Biophys Res Commun. 2005;338:923\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejphar.2008.03.008","volume":"585","author":"AW Boots","year":"2008","unstructured":"Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585:325\u201337.","journal-title":"Eur J Pharmacol"},{"key":"12_CR7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfr239","volume":"124","author":"JR Cannon","year":"2011","unstructured":"Cannon JR, Greenamyre JT. The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicol Sci. 2011;124:225\u201350.","journal-title":"Toxicol Sci"},{"key":"12_CR8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4068\/cmj.2014.50.2.45","volume":"50","author":"SM Choi","year":"2014","unstructured":"Choi SM, Kim BC, Cho YH, Choi KH, Chang J, Park MS, Kim MK, Cho KH, Kim JK. Effects of flavonoid compounds on \u03b2-amyloid-peptide-induced neuronal death in cultured mouse cortical neurons. Chonnam Med J. 2014;50:45\u201351.","journal-title":"Chonnam Med J"},{"key":"12_CR9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jep.2012.07.005","volume":"143","author":"F Dajas","year":"2012","unstructured":"Dajas F. Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol. 2012;143:383\u201396.","journal-title":"J Ethnopharmacol"},{"key":"12_CR10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1871524911313010005","volume":"13","author":"F Dajas","year":"2013","unstructured":"Dajas F, Andr\u00e9s AC, Florencia A, Carolina E, Felicia RM. Neuroprotective actions of flavones and flavonols: mechanisms and relationship to flavonoid structural features. Cent Nerv Syst Agents Med Chem. 2013;13:30\u20135.","journal-title":"Cent Nerv Syst Agents Med Chem"},{"key":"12_CR11","first-page":"348","volume":"43","author":"M D\u2019Archivio","year":"2007","unstructured":"D\u2019Archivio M, Filesi C, Di Benedetto R, Gargiulo R, Giovannini C, Masella R. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita. 2007;43:348\u201361.","journal-title":"Ann Ist Super Sanita"},{"key":"12_CR12","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1093\/jn\/135.7.1718","volume":"135","author":"VC Boer de","year":"2005","unstructured":"de Boer VC, Dihal AA, vander Woude H, Arts IC, Wolffram S, Alink GM, et al. Tissue distribution of quercetin in rats and pigs. J Nutr. 2005;135:1718\u201325.","journal-title":"J Nutr"},{"key":"12_CR13","doi-asserted-by":"crossref","first-page":"14941","DOI":"10.1074\/jbc.M109.080390","volume":"285","author":"S Giovanni Di","year":"2010","unstructured":"Di Giovanni S, Eleuteri S, Paleologou KE, Yin G, Zweckstetter M, Carrupt PA, Lashuel HA. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010;285:14941\u201354.","journal-title":"J Biol Chem"},{"key":"12_CR14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3945\/an.110.000026","volume":"2","author":"S Egert","year":"2011","unstructured":"Egert S, Rimbach G. Which sources of flavonoids: complex diets or dietary supplements? Adv Nutr. 2011;2:8\u201314.","journal-title":"Adv Nutr"},{"key":"12_CR15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jnutbio.2009.01.014","volume":"21","author":"M Fiorania","year":"2010","unstructured":"Fiorania M, Guidarellib A, Blasaa M, Azzolinia C, Candiraccia M, Piattia E, Canton H. Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extra mitochondrial fraction of the flavonoid. J Nutr Biochem. 2010;21:397\u2013404.","journal-title":"J Nutr Biochem"},{"key":"12_CR16","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","volume":"140","author":"CK Glass","year":"2010","unstructured":"Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010;140:918\u201334.","journal-title":"Cell"},{"issue":"3","key":"12_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jnutbio.2014.10.008","volume":"26","author":"Y Guo","year":"2015","unstructured":"Guo Y, Bruno RS. Endogenous and exogenous mediators of quercetin bioavailability. J Nutr Biochem. 2015;26(3):201\u201310. doi: 10.1016\/j.jnutbio.2014.10.008 .","journal-title":"J Nutr Biochem"},{"key":"12_CR18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1039\/np9941100041","volume":"11","author":"E Haslam","year":"1994","unstructured":"Haslam E, Cai Y. Plant polyphenols (vegetable tannins): gallic acid metabolism. Nat Prod Rep. 1994;11:41\u201366.","journal-title":"Nat Prod Rep"},{"key":"12_CR19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jyp.2013.11.005","volume":"5","author":"MR Islam","year":"2013","unstructured":"Islam MR, Zaman A, Jahan I, Chakravorty R, Chakraborty S. In silico QSAR analysis of quercetin reveals its potential as therapeutic drug for Alzheimer\u2019s disease. J Young Pharm. 2013;5:173\u20139.","journal-title":"J Young Pharm"},{"key":"12_CR20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10863-010-9286-7","volume":"42","author":"YN Jin","year":"2010","unstructured":"Jin YN, Johnson GV. The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease. J Bioenerg Biomembr. 2010;42:199\u2013205.","journal-title":"J Bioenerg Biomembr"},{"key":"12_CR21","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.3390\/12092130","volume":"12","author":"M Jung","year":"2007","unstructured":"Jung M, Park M. Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa. Molecules. 2007;12:2130\u20139.","journal-title":"Molecules"},{"key":"12_CR22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.lfs.2009.12.014","volume":"86","author":"TK Kao","year":"2010","unstructured":"Kao TK, Ou YC, Raung SL, Lai CY, Liao SL, Chen CJ. Inhibition of nitric oxide production by quercetin in endotoxin\/cytokine-stimulated microglia. Life Sci. 2010;86:315\u201321.","journal-title":"Life Sci"},{"key":"12_CR23","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.3390\/molecules15117792","volume":"15","author":"NA Kelsey","year":"2010","unstructured":"Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules. 2010;15:7792\u2013814.","journal-title":"Molecules"},{"key":"12_CR24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/ptr.1486","volume":"18","author":"MS Kim","year":"2004","unstructured":"Kim MS, Lee JI, Lee WY, Kim SE. Neuroprotective effect of Ginkgo biloba L. extract in a rat model of Parkinson\u2019s disease. Phytother Res. 2004;18:663\u20136.","journal-title":"Phytother Res"},{"key":"12_CR25","doi-asserted-by":"crossref","first-page":"8537","DOI":"10.1021\/jf051985c","volume":"53","author":"H Kim","year":"2005","unstructured":"Kim H, Park BS, Lee KG, Choi CY, Jang SS, Kim YH, Lee SE. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. J Agric Food Chem. 2005;53:8537\u201341.","journal-title":"J Agric Food Chem"},{"key":"12_CR26","first-page":"79","volume":"65","author":"A Koz\u0142owska","year":"2014","unstructured":"Koz\u0142owska A, Szostak-Wegierek D. Flavonoids\u2014food sources and health benefits. Rocz Panstw Zakl Hig. 2014;65:79\u201385.","journal-title":"Rocz Panstw Zakl Hig"},{"key":"12_CR27","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/ptr.2454","volume":"22","author":"A Kumar","year":"2008","unstructured":"Kumar A, Sehgal N, Kumar P, et al. Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. Phytother Res. 2008;22:1563\u20139.","journal-title":"Phytother Res"},{"key":"12_CR28","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00701-010-0889-x","volume":"153","author":"JK Lee","year":"2011","unstructured":"Lee JK, Kwak HJ, Piao MS, Jang JW, Kim SH, Kim HS. Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats. Acta Neurochir. 2011;153:1321\u20139.","journal-title":"Acta Neurochir"},{"key":"12_CR29","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/aje\/kwm036","volume":"165","author":"L Letenneur","year":"2007","unstructured":"Letenneur L, Proust-Lima C, Gouge AL, Dartigues JF, Barberger-Gateau P. Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol. 2007;165:1364\u201371.","journal-title":"Am J Epidemiol"},{"key":"12_CR30","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006;443:787\u201395.","journal-title":"Nature"},{"key":"12_CR31","doi-asserted-by":"crossref","first-page":"17048","DOI":"10.1074\/jbc.M110797200","volume":"277","author":"TK Lin","year":"2002","unstructured":"Lin TK, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RA, Murphy MP. Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem. 2002;277:17048\u201356.","journal-title":"J Biol Chem"},{"key":"12_CR32","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1021\/jf303387d","volume":"61","author":"CM Liu","year":"2013","unstructured":"Liu CM, Zheng GH, Cheng C, Sun JM. Quercetin protects mouse brain against lead-induced neurotoxicity. J Agric Food Chem. 2013;61:7630\u20135.","journal-title":"J Agric Food Chem"},{"key":"12_CR33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bbr.2006.03.043","volume":"171","author":"J Lu","year":"2006","unstructured":"Lu J, Zheng YL, Luo L, et al. Quercetin reverses D-galactose induced neurotoxicity in mouse brain. Behav Brain Res. 2006;171:251\u201360.","journal-title":"Behav Brain Res"},{"key":"12_CR34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2754","volume":"222","author":"J Lu","year":"2010","unstructured":"Lu J, Wu DM, Zheng YL, Hu B, Zhang ZF, Shan Q, Zheng ZH, Liu CM, Wang YJ. Quercetin activates AMP-activated protein kinase by reducing PP2C expression, protecting old mouse brain against high cholesterol-induced neurotoxicity. J Pathol. 2010;222:199\u2013212.","journal-title":"J Pathol"},{"key":"12_CR35","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","volume":"9","author":"C Manach","year":"2004","unstructured":"Manach C, Scalbert A, Morand C, R\u00e9m\u00e9sy C, Jim\u00e9nez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;9:727\u201347.","journal-title":"Am J Clin Nutr"},{"key":"12_CR36","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/eji.1830270142","volume":"27","author":"P Marchetti","year":"1997","unstructured":"Marchetti P, Decaudin D, Macho A, Zamzami N, Hirsch T, Susin SA, Kroemer G. Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function. Eur J Immunol. 1997;27:289\u201396.59.","journal-title":"Eur J Immunol"},{"key":"12_CR37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1471-4159.1997.68010255.x","volume":"68","author":"RJ Mark","year":"1997","unstructured":"Mark RJ, Lovell MA, Markesbery WR, Uchida K, Mattson MP. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J Neurochem. 1997;68:255\u201364.","journal-title":"J Neurochem."},{"key":"12_CR38","volume-title":"Anthocyanins in fruits, vegetables and grains","author":"G Mazza","year":"1994","unstructured":"Mazza G, Maniati E. Anthocyanins in fruits, vegetables and grains. Boca Raton, FL: CRC Press; 1994."},{"key":"12_CR39","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/nure.12152","volume":"72","author":"SL Miles","year":"2014","unstructured":"Miles SL, McFarland M, Niles RM. Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human diseases. Nutr Rev. 2014;72:720\u201334.","journal-title":"Nutr Rev"},{"key":"12_CR40","first-page":"685","volume":"8","author":"GL Oliveira","year":"2014","unstructured":"Oliveira GL, et al. Potential involvement of oxidative stress in the induction of neurodegenerative diseases: actions, mechanisms and neurotherapeutic potential of natural antioxidants. Afr J Pharm. 2014;8:685\u2013700.","journal-title":"Afr J Pharm"},{"key":"12_CR41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1517\/14740330903026944","volume":"8","author":"B Ossola","year":"2009","unstructured":"Ossola B, K\u00e4\u00e4ri\u00e4inen TM, M\u00e4nnist\u00f6 PT. The multiple faces of quercetin in neuroprotection. Expert Opin Drug Saf. 2009;8:397\u2013409.","journal-title":"Expert Opin Drug Saf"},{"key":"12_CR42","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","volume":"2","author":"KB Pandey","year":"2009","unstructured":"Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2:270\u20138.","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"12_CR43","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1517\/13543784.2013.794783","volume":"22","author":"L Pathak","year":"2013","unstructured":"Pathak L, Agrawal Y, Dhir A. Natural polyphenols in the management of major depression. Expert Opin Investig Drugs. 2013;22(7):863\u201380.","journal-title":"Expert Opin Investig Drugs"},{"key":"12_CR44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2174\/156720511796391908","volume":"8","author":"CB Pocernich","year":"2011","unstructured":"Pocernich CB, Lange ML, Sultana R, Butterfield DA. Nutritional approaches to modulate oxidative stress in Alzheimer\u2019s disease. Curr Alzheimer Res. 2011;8:452\u201369.","journal-title":"Curr Alzheimer Res"},{"key":"12_CR45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1022457605436","volume":"23","author":"MR Prasad","year":"1998","unstructured":"Prasad MR, Lovell MA, Yatin M, Dhillon H, Markesbery WR. Regional membrane phospholipid alterations in Alzheimer\u2019s disease. Neurochem Res. 1998;23:81\u20138.","journal-title":"Neurochem Res"},{"key":"12_CR46","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"HW Querfurth","year":"2010","unstructured":"Querfurth HW, LaFerla FM. Mechanisms of disease. N Engl J Med. 2010;362:329\u201344.","journal-title":"N Engl J Med"},{"key":"12_CR47","first-page":"246","volume":"71","author":"C Rendeiro","year":"2012","unstructured":"Rendeiro C, Guerreiro JD, Williams CM, Spencer JP. Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioral effects. Proc Genes Soc. 2012;71:246\u201362.","journal-title":"Proc Genes Soc"},{"key":"12_CR48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bcp.2011.08.010","volume":"83","author":"M Russo","year":"2012","unstructured":"Russo M, Spangnulo C, Tedesco I, Bilotto S, Russo GL. The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol. 2012;83:6\u201315.","journal-title":"Biochem Pharmacol"},{"key":"12_CR49","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuropharm.2015.01.027","volume":"93C","author":"AM Sabogal-Gu\u00e1queta","year":"2015","unstructured":"Sabogal-Gu\u00e1queta AM, Mu\u00f1oz-Manco JI, Ram\u00edrez-Pineda JR, Lamprea-Rodriguez M, Osorio E, Cardona-G\u00f3mez GP. The flavonoid quercetin ameliorates Alzheimer\u2019s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer\u2019s disease model mice. Neuropharmacology. 2015;93C:134\u201345.","journal-title":"Neuropharmacology"},{"key":"12_CR50","first-page":"421","volume":"2013","author":"R Sandhir","year":"1832","unstructured":"Sandhir R, Mehrotra A. Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: implications in Huntington\u2019s disease. Biochim Biophys Acta. 1832;2013:421\u201330.","journal-title":"Biochim Biophys Acta"},{"key":"12_CR51","doi-asserted-by":"crossref","first-page":"2073S","DOI":"10.1093\/jn\/130.8.2073S","volume":"130","author":"A Scalbert","year":"2000","unstructured":"Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr. 2000;130:2073S\u201385.","journal-title":"J Nutr"},{"key":"12_CR52","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1089\/089771503767168500","volume":"20","author":"E Schultke","year":"2003","unstructured":"Schultke E, Kendall E, Kamencic H, Ghong Z, Griebel RW, Juurlink BHJ. Quercetin promotes recovery from acute spinal cord injury: an MRI supported efficacious dose determination. J Neurotrauma. 2003;20:583\u201391.","journal-title":"J Neurotrauma"},{"key":"12_CR53","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0006-2952(97)00672-2","volume":"55","author":"CK Sen","year":"1998","unstructured":"Sen CK. Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochem Pharmacol. 1998;55:1747\u201358.","journal-title":"Biochem Pharmacol"},{"key":"12_CR54","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/mds.25249","volume":"28","author":"AB Singleton","year":"2013","unstructured":"Singleton AB, Farrer MJ, Bonifati V. The genetics of Parkinson\u2019s disease: progress and therapeutic implications. Mov Disord. 2013;28:14\u201323.","journal-title":"Mov Disord"},{"key":"12_CR55","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1471-4159.1999.0730443.x","volume":"73","author":"DH Small","year":"1999","unstructured":"Small DH, McLean CA. Alzheimer\u2019s disease and the amyloid beta protein: what is the role of amyloid? J Neurochem. 1999;73:443\u20139.","journal-title":"J Neurochem"},{"key":"12_CR56","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12263-007-0056-z","volume":"2","author":"JP Spencer","year":"2007","unstructured":"Spencer JP. Interactions of flavonoids within neuronal signalling pathways. Genes Nutr. 2007;2:257\u201373.","journal-title":"Genes Nutr"},{"key":"12_CR57","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12263-009-0136-3","volume":"4","author":"JP Spencer","year":"2009","unstructured":"Spencer JP. Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes Nutr. 2009;4:243\u201350.","journal-title":"Genes Nutr"},{"key":"12_CR58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2009.10.003","volume":"492","author":"JP Spencer","year":"2009","unstructured":"Spencer JP, Vauzour D, Rendeiro C. Flavonoids and cognition: the molecular mechanisms underlying their behavioral effects. Arch Biochem Biophys. 2009;492:1\u20139.","journal-title":"Arch Biochem Biophys"},{"key":"12_CR59","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mam.2011.10.016","volume":"33","author":"JP Spencer","year":"2012","unstructured":"Spencer JP, Vafeiadou K, Williams RJ, Vauzour D. Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med. 2012;33:83\u201397.","journal-title":"Mol Aspects Med"},{"key":"12_CR60","doi-asserted-by":"crossref","first-page":"823206","DOI":"10.1155\/2012\/823206","volume":"2012","author":"N Sriraksa","year":"2012","unstructured":"Sriraksa N, Wattanathorn J, Muchimapura S, Tiamkao S, Brown K, Chaisiwamongkol K. Cognitive-enhancing effect of quercetin in a rat model of Parkinson\u2019s disease induced by 6-hydroxydopamine. Evid Based Complement Alternat Med. 2012;2012:823206.","journal-title":"Evid Based Complement Alternat Med"},{"key":"12_CR61","doi-asserted-by":"crossref","first-page":"914273","DOI":"10.1155\/2012\/914273","volume":"2012","author":"D Vauzour","year":"2012","unstructured":"Vauzour D. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev. 2012;2012:914273.","journal-title":"Oxid Med Cell Longev"},{"key":"12_CR62","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","volume":"57","author":"JP Vonsattel","year":"1998","unstructured":"Vonsattel JP, DiFiglia M. Huntington disease. J Neuropathol Exp Neurol. 1998;57:369\u201384.","journal-title":"J Neuropathol Exp Neurol"},{"key":"12_CR63","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0891-5849(00)00510-4","volume":"30","author":"KA Youdim","year":"2001","unstructured":"Youdim KA, Joseph JA. A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Radic Biol Med. 2001;30:583\u201394.","journal-title":"Free Radic Biol Med"}],"updated-by":[{"DOI":"10.1007\/978-3-319-28383-8_24","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000}}],"container-title":["Advances in Neurobiology","The Benefits of Natural Products for Neurodegenerative Diseases"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-28383-8_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T16:06:16Z","timestamp":1568390776000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-28383-8_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9783319283814","9783319283838"],"references-count":63,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-28383-8_12","relation":{"erratum":[{"id-type":"doi","id":"10.1007\/978-3-319-28383-8_24","asserted-by":"object"}]},"ISSN":["2190-5215","2190-5223"],"issn-type":[{"value":"2190-5215","type":"print"},{"value":"2190-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}