{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:31:10Z","timestamp":1791293470177,"version":"4.1.0"},"publisher-location":"Cham","reference-count":143,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319411705","type":"print"},{"value":"9783319411712","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-3-319-41171-2_5","type":"book-chapter","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T07:11:21Z","timestamp":1469517081000},"page":"91-115","source":"Crossref","is-referenced-by-count":9,"title":["The Orchestra and Its Maestro: Shigella\u2019s Fine-Tuning of the Inflammasome Platforms"],"prefix":"10.1007","author":[{"given":"Anna-Karin","family":"Hermansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Paciello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lina","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"issue":"9","key":"5_CR1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ni1496","volume":"8","author":"EV Acosta-Rodriguez","year":"2007","unstructured":"Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F (2007) Interleukins 1\u03b2 and 6 but not transforming growth factor-\u03b2 are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8(9):942\u2013949","journal-title":"Nat Immunol"},{"issue":"12","key":"5_CR2","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/intimm\/13.12.1595","volume":"13","author":"S Akashi","year":"2001","unstructured":"Akashi S, Nagai Y, Ogata H, Oikawa M, Fukase K, Kusumoto S, Kawasaki K, Nishijima M, Hayashi S, Kimoto M, Miyake K (2001) Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition. Int Immunol 13(12):1595\u20131599","journal-title":"Int Immunol"},{"issue":"2","key":"5_CR3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(00)81334-3","volume":"87","author":"ES Alnemri","year":"1996","unstructured":"Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J (1996) Human ICE\/CED-3 protease nomenclature. Cell 87(2):171","journal-title":"Cell"},{"issue":"46","key":"5_CR4","doi-asserted-by":"crossref","first-page":"35217","DOI":"10.1074\/jbc.M604933200","volume":"281","author":"A Amer","year":"2006","unstructured":"Amer A, Franchi L, Kanneganti TD, Body-Malapel M, \u00d6z\u00f6ren N, Brady G, Meshinchi S, Jagirdar R, Gewirtz A, Akira S, N\u00fa\u00f1ez G (2006) Regulation of Legionella phagosome maturation and infection through flagellin and host ipaf. J Biol Chem 281(46):35217\u201335223","journal-title":"J Biol Chem"},{"issue":"25","key":"5_CR5","doi-asserted-by":"crossref","first-page":"E3282","DOI":"10.1073\/pnas.1509091112","volume":"112","author":"ET Arena","year":"2015","unstructured":"Arena ET, Campbell-Valois FX, Tinevez JY, Nigro G, Sachse M, Moya-Nilges M, Nothelfer K, Marteyn B, Shorte SL, Sansonetti PJ (2015) Bioimage analysis of Shigella infection reveals targeting of colonic crypts. Proc Natl Acad Sci USA 112(25):E3282\u2013E3290","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"5_CR6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s10875-009-9359-8","volume":"30","author":"AK Bagchi","year":"2010","unstructured":"Bagchi AK, Sinha AK, Adhikari R, Maiti P, Mukherjee J, Panda A, Saha DR (2010) Selective deletion of CD8(+) cells upregulated by caspases-1 via IL-18 in mice immunized with major outer membrane protein of Shigella dysenteriae 1 following infection. J Clin Immunol 30(3):408\u2013418","journal-title":"J Clin Immunol"},{"issue":"5","key":"5_CR7","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1128\/IAI.65.5.1599-1605.1997","volume":"65","author":"S B\u00e2rzu","year":"1997","unstructured":"B\u00e2rzu S, Benjelloun-Touimi Z, Phalipon A, Sansonetti P, Parsot C (1997) Functional analysis of the Shigella flexneri IpaC invasin by insertional mutagenesis. Infect Immun 65(5):1599\u20131605","journal-title":"Infect Immun"},{"issue":"2","key":"5_CR8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","volume":"183","author":"F Bauernfeind","year":"2009","unstructured":"Bauernfeind F, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E (2009) NF-\u03baB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183(2):787\u2013791","journal-title":"J Immunol"},{"issue":"3","key":"5_CR9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.chom.2012.01.013","volume":"11","author":"J Bergounioux","year":"2012","unstructured":"Bergounioux J, Elisee R, Prunier AL, Donnadieu F, Sperandio B, Sansonetti P, Arbibe L (2012) Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium\u2019s epithelial niche. Cell Host Microbe 11(3):240\u2013252","journal-title":"Cell Host Microbe"},{"issue":"10","key":"5_CR10","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1073\/pnas.86.10.3867","volume":"86","author":"ML Bernardini","year":"1989","unstructured":"Bernardini ML, Mounier J, d\u2019Hauteville H, Coquis-Rondon M, Sansonetti PJ (1989) Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. Proc Natl Acad Sci USA 86(10):3867\u20133871","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"5_CR11","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/infdis\/155.6.1260","volume":"155","author":"RE Black","year":"1987","unstructured":"Black RE, Levine MM, Clements ML, Losonsky G, Herrington D, Berman S, Formal SB (1987) Prevention of shigellosis by a Salmonella typhi-Shigella sonnei bivalent vaccine. J Infect Dis 155(6):1260\u20131265","journal-title":"J Infect Dis"},{"issue":"3","key":"5_CR12","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1083\/jcb.147.3.683","volume":"147","author":"A Blocker","year":"1999","unstructured":"Blocker A, Gounon P, Larquet E, Niebuhr K, Cabiaux V, Parsot C, Sansonetti P (1999) The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes. J Cell Biol 147(3):683\u2013693","journal-title":"J Cell Biol"},{"issue":"6","key":"5_CR13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2010.11.007","volume":"8","author":"P Broz","year":"2010","unstructured":"Broz P, von Moltke J, Jones JW, Vance RE, Monack DM (2010) Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 8(6):471\u2013483","journal-title":"Cell Host Microbe"},{"issue":"1","key":"5_CR14","doi-asserted-by":"crossref","first-page":"e00620-12","DOI":"10.1128\/mBio.00620-12","volume":"4","author":"BG Byrne","year":"2013","unstructured":"Byrne BG, Dubuisson JF, Joshi AD, Persson JJ, Swanson MS (2013) Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection. MBio 4(1):e00620-12","journal-title":"MBio"},{"issue":"11","key":"5_CR15","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.4049\/jimmunol.1200195","volume":"188","author":"S Cai","year":"2012","unstructured":"Cai S, Batra S, Wakamatsu N, Pacher P, Jeyaseelan S (2012) NLRC4 inflammasome-mediated production of IL-1\u03b2 modulates mucosal immunity in the lung against gram-negative bacterial infection. J Immunol 188(11):5623\u20135635","journal-title":"J Immunol"},{"issue":"10","key":"5_CR16","doi-asserted-by":"crossref","first-page":"a016717","DOI":"10.1101\/cshperspect.a016717","volume":"3","author":"N Carayol","year":"2013","unstructured":"Carayol N, Tran Van Nhieu G (2013) The inside story of Shigella invasion of intestinal epithelial cells. Cold Spring Harb Perspect Med 3(10):a016717","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"5_CR17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chom.2008.12.011","volume":"5","author":"LA Carneiro","year":"2009","unstructured":"Carneiro LA, Travassos LH, Soares F, Tattoli I, Magalhaes JG, Bozza MT, Plotkowski MC, Sansonetti PJ, Molkentin JD, Philpott DJ, Girardin SE (2009) Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe 5(2):123\u2013136","journal-title":"Cell Host Microbe"},{"issue":"12","key":"5_CR18","doi-asserted-by":"crossref","first-page":"e1002452","DOI":"10.1371\/journal.ppat.1002452","volume":"7","author":"I Ceballos-Olvera","year":"2011","unstructured":"Ceballos-Olvera I, Sahoo M, Miller MA, Del Barrio L, Re F (2011) Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1\u03b2 is deleterious. PLoS Pathog 7(12):e1002452","journal-title":"PLoS Pathog"},{"issue":"2","key":"5_CR19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1128\/IAI.66.2.549-557.1998","volume":"66","author":"A Cersini","year":"1998","unstructured":"Cersini A, Salvia AM, Bernardini ML (1998) Intracellular multiplication and virulence of Shigella flexneri auxotrophic mutants. Infect Immun 66(2):549\u2013557","journal-title":"Infect Immun"},{"issue":"15","key":"5_CR20","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1002\/j.1460-2075.1996.tb00759.x","volume":"15","author":"Y Chen","year":"1996","unstructured":"Chen Y, Smith MR, Thirumalai K, Zychlinsky A (1996) A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J 15(15):3853\u20133860","journal-title":"EMBO J"},{"issue":"2","key":"5_CR21","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.celrep.2014.06.028","volume":"8","author":"KW Chen","year":"2014","unstructured":"Chen KW, Gro\u00df CJ, Sotomayor FV, Stacey KJ, Tschopp J, Sweet MJ, Schroder K (2014) The neutrophil NLRC4 inflammasome selectively promotes IL-1\u03b2 maturation without pyroptosis during acute Salmonella challenge. Cell Rep 8(2):570\u2013582","journal-title":"Cell Rep"},{"issue":"11","key":"5_CR22","doi-asserted-by":"crossref","first-page":"e1003047","DOI":"10.1371\/journal.ppat.1003047","volume":"8","author":"JS Cho","year":"2012","unstructured":"Cho JS, Guo Y, Ramos RI, Hebroni F, Plaisier SB, Xuan C, Granick JL, Matsushima H, Takashima A, Iwakura Y, Cheung AL, Cheng G, Lee DJ, Simon SI, Miller LS (2012) Neutrophil-derived IL-1\u03b2 is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog 8(11):e1003047","journal-title":"PLoS Pathog"},{"issue":"5","key":"5_CR23","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1128\/IAI.01866-06","volume":"75","author":"CS Clark","year":"2007","unstructured":"Clark CS, Maurelli AT (2007) Shigella flexneri inhibits staurosporine-induced apoptosis in epithelial cells. Infect Immun 75(5):2531\u20132539","journal-title":"Infect Immun"},{"issue":"3","key":"5_CR24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0769-2609(86)80041-2","volume":"137A","author":"P Clerc","year":"1986","unstructured":"Clerc P, Ryter A, Mounier J, Sansonetti PJ (1986) Plasmid-mediated intracellular multiplication of Shigella flexneri. Ann Inst Pasteur Microbiol 137A(3):315\u2013320","journal-title":"Ann Inst Pasteur Microbiol"},{"issue":"2","key":"5_CR25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/ije\/20.2.546","volume":"20","author":"D Cohen","year":"1991","unstructured":"Cohen D, Slepon R, Green MS (1991) Sociodemographic factors associated with serum anti-Shigella lipopolysaccharide antibodies and shigellosis. Int J Epidemiol 20(2):546\u2013550","journal-title":"Int J Epidemiol"},{"issue":"3","key":"5_CR26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0966-842X(00)01936-3","volume":"9","author":"BT Cookson","year":"2001","unstructured":"Cookson BT, Brennan MA (2001) Pro-inflammatory programmed cell death. Trends Microbiol 9(3):113\u2013114","journal-title":"Trends Microbiol"},{"issue":"7","key":"5_CR27","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1128\/IAI.67.7.3437-3443.1999","volume":"67","author":"TS Coster","year":"1999","unstructured":"Coster TS, Hoge CW, VanDeVerg LL, Hartman AB, Oaks EV, Venkatesan MM, Cohen D, Robin G, Fontaine-Thompson A, Sansonetti PJ, Hale TL (1999) Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602. Infect Immun 67(7):3437\u20133443","journal-title":"Infect Immun"},{"issue":"18","key":"5_CR28","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1046\/j.1432-1327.2000.01649.x","volume":"267","author":"C Geyter De","year":"2000","unstructured":"De Geyter C, Wattiez R, Sansonetti P, Falmagne P, Ruysschaert JM, Parsot C, Cabiaux V (2000) Characterization of the interaction of IpaB and IpaD, proteins required for entry of Shigella flexneri into epithelial cells, with a lipid membrane. Eur J Biochem 267(18):5769\u20135776","journal-title":"Eur J Biochem"},{"issue":"7484","key":"5_CR29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature12940","volume":"505","author":"G Doitsh","year":"2014","unstructured":"Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Mu\u00f1oz-Arias I, Greene WC (2014) Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature 505(7484):509\u2013514","journal-title":"Nature"},{"issue":"6","key":"5_CR30","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/infdis\/159.6.1126","volume":"159","author":"HL DuPont","year":"1989","unstructured":"DuPont HL, Levine MM, Hornick RB, Formal SB (1989) Inoculum size in shigellosis and implications for expected mode of transmission. J Infect Dis 159(6):1126\u20131128","journal-title":"J Infect Dis"},{"issue":"2","key":"5_CR31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.chom.2009.07.005","volume":"6","author":"N Dupont","year":"2009","unstructured":"Dupont N, Lacas-Gervais S, Bertout J, Paz I, Freche B, Van Nhieu GT, van der Goot FG, Sansonetti PJ, Lafont F (2009) Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 6(2):137\u2013149","journal-title":"Cell Host Microbe"},{"issue":"5","key":"5_CR32","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/1521-4141(200205)32:5<1464::AID-IMMU1464>3.0.CO;2-G","volume":"32","author":"JD Edgeworth","year":"2002","unstructured":"Edgeworth JD, Spencer J, Phalipon A, Griffin GE, Sansonetti PJ (2002) Cytotoxicity and interleukin-1\u03b2 processing following Shigella flexneri infection of human monocyte-derived dendritic cells. Eur J Immunol 32(5):1464\u20131471","journal-title":"Eur J Immunol"},{"issue":"6","key":"5_CR33","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1083\/jcb.146.6.1319","volume":"146","author":"C Egile","year":"1999","unstructured":"Egile C, Loisel TP, Laurent V, Li R, Pantaloni D, Sansonetti PJ, Carlier MF (1999) Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2\/3 complex and bacterial actin-based motility. J Cell Biol 146(6):1319\u20131332","journal-title":"J Cell Biol"},{"key":"5_CR34","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/1471-2164-11-272","volume":"11","author":"CS Faherty","year":"2010","unstructured":"Faherty CS, Merrell DS, Semino-Mora C, Dubois A, Ramaswamy AV, Maurelli AT (2010) Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition. BMC Genom 11:272","journal-title":"BMC Genom"},{"issue":"7","key":"5_CR35","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1164\/rccm.201307-1358OC","volume":"189","author":"E Faure","year":"2014","unstructured":"Faure E, Mear JB, Faure K, Normand S, Couturier-Maillard A, Grandjean T, Balloy V, Ryffel B, Dessein R, Chignard M, Uyttenhove C, Guery B, Gosset P, Chamaillard M, Kipnis E (2014) Pseudomonas aeruginosa type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome. Am J Respir Crit Care Med 189(7):799\u2013811","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"5_CR36","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1128\/iai.65.4.1486-1496.1997","volume":"65","author":"CM Fernandez-Prada","year":"1997","unstructured":"Fernandez-Prada CM, Hoover DL, Tall BD, Venkatesan MM (1997) Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosis. Infect Immun 65(4):1486\u20131496","journal-title":"Infect Immun"},{"issue":"6","key":"5_CR37","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/oxfordjournals.aje.a116134","volume":"134","author":"C Ferreccio","year":"1991","unstructured":"Ferreccio C, Prado V, Ojeda A, Cayyazo M, Abrego P, Guers L, Levine MM (1991) Epidemiologic patterns of acute diarrhea and endemic Shigella infections in children in a poor periurban setting in Santiago. Chile. Am J Epidemiol 134(6):614\u2013627","journal-title":"Chile. Am J Epidemiol"},{"issue":"6","key":"5_CR38","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ni1346","volume":"7","author":"L Franchi","year":"2006","unstructured":"Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Nunez G (2006) Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1\u03b2 in Salmonella-infected macrophages. Nat Immunol 7(6):576\u2013582","journal-title":"Nat Immunol"},{"issue":"5","key":"5_CR39","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ni.2263","volume":"13","author":"L Franchi","year":"2012","unstructured":"Franchi L, Kamada N, Nakamura Y, Burberry A, Kuffa P, Suzuki S, Shaw MH, Kim YG, N\u00fa\u00f1ez G (2012) NLRC4-driven interleukin-1\u03b2 production discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol 13(5):449\u2013456","journal-title":"Nat Immunol"},{"issue":"4","key":"5_CR40","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.chom.2012.03.001","volume":"11","author":"M Fukumatsu","year":"2012","unstructured":"Fukumatsu M, Ogawa M, Arakawa S, Suzuki M, Nakayama K, Shimizu S, Kim M, Mimuro H, Sasakawa C (2012) Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. Cell Host Microbe 11(4):325\u2013336","journal-title":"Cell Host Microbe"},{"issue":"8","key":"5_CR41","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/embo-reports\/kve155","volume":"2","author":"SE Girardin","year":"2001","unstructured":"Girardin SE, Tournebize R, Mavris M, Page AL, Li X, Stark GR, Bertin J, DiStefano PS, Yaniv M, Sansonetti PJ, Philpott DJ (2001) CARD4\/Nod1 mediates NF-\u03baB and JNK activation by invasive Shigella flexneri. EMBO Rep 2(8):736\u2013742","journal-title":"EMBO Rep"},{"issue":"1","key":"5_CR42","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1128\/iai.61.1.364-367.1993","volume":"61","author":"J Gorden","year":"1993","unstructured":"Gorden J, Small PL (1993) Acid resistance in enteric bacteria. Infect Immun 61(1):364\u2013367","journal-title":"Infect Immun"},{"issue":"2","key":"5_CR43","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/infdis\/175.2.470","volume":"175","author":"A Guichon","year":"1997","unstructured":"Guichon A, Zychlinsky A (1997) Clinical isolates of Shigella species induce apoptosis in macrophages. J Infect Dis 175(2):470\u2013473","journal-title":"J Infect Dis"},{"issue":"6151","key":"5_CR44","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1240988","volume":"341","author":"JA Hagar","year":"2013","unstructured":"Hagar JA, Powell DA, Aachoui Y, Ernst RK, Miao EA (2013) Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science 341(6151):1250\u20131253","journal-title":"Science"},{"issue":"3","key":"5_CR45","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1128\/IAI.24.3.887-894.1979","volume":"24","author":"TL Hale","year":"1979","unstructured":"Hale TL, Morris RE, Bonventre PF (1979) Shigella infection of henle intestinal epithelial cells: role of the host cell. Infect Immun 24(3):887\u2013894","journal-title":"Infect Immun"},{"issue":"3","key":"5_CR46","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1365-2958.2005.04568.x","volume":"56","author":"RD Hayward","year":"2005","unstructured":"Hayward RD, Cain RJ, McGhie EJ, Phillips N, Garner MJ, Koronakis V (2005) Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells. Mol Microbiol 56(3):590\u2013603","journal-title":"Mol Microbiol"},{"issue":"5","key":"5_CR47","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/j.1460-2075.1992.tb05253.x","volume":"11","author":"N High","year":"1992","unstructured":"High N, Mounier J, Pr\u00e9vost MC, Sansonetti PJ (1992) IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole. EMBO J 11(5):1991\u20131999","journal-title":"EMBO J"},{"issue":"12","key":"5_CR48","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1128\/IAI.65.12.5165-5170.1997","volume":"65","author":"H Hilbi","year":"1997","unstructured":"Hilbi H, Chen Y, Thirumalai K, Zychlinsky A (1997) The interleukin 1\u03b2-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages. Infect Immun 65(12):5165\u20135170","journal-title":"Infect Immun"},{"issue":"49","key":"5_CR49","doi-asserted-by":"crossref","first-page":"32895","DOI":"10.1074\/jbc.273.49.32895","volume":"273","author":"H Hilbi","year":"1998","unstructured":"Hilbi H, Moss JE, Hersh D, Chen Y, Arondel J, Banerjee S, Flavell RA, Yuan J, Sansonetti PJ, Zychlinsky A (1998) Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J Biol Chem 273(49):32895\u201332900","journal-title":"J Biol Chem"},{"issue":"1","key":"5_CR50","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","volume":"30","author":"H Ishigame","year":"2009","unstructured":"Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y (2009) Differential roles of interleukin-17A and \u221217F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30(1):108\u2013119","journal-title":"Immunity"},{"issue":"2","key":"5_CR51","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/IAI.65.2.739-749.1997","volume":"65","author":"D Islam","year":"1997","unstructured":"Islam D, Veress B, Bardhan PK, Lindberg AA, Christensson B (1997a) In situ characterization of inflammatory responses in the rectal mucosae of patients with shigellosis. Infect Immun 65(2):739\u2013749","journal-title":"Infect Immun"},{"issue":"6","key":"5_CR52","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/jcp.50.6.513","volume":"50","author":"D Islam","year":"1997","unstructured":"Islam D, Veress B, Bardhan PK, Lindberg AA, Christensson B (1997b) Quantitative assessment of IgG and IgA subclass producing cells in rectal mucosa during shigellosis. J Clin Pathol 50(6):513\u2013520","journal-title":"J Clin Pathol"},{"issue":"5","key":"5_CR53","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1128\/IAI.00939-10","volume":"79","author":"SP Jehl","year":"2011","unstructured":"Jehl SP, Doling AM, Giddings KS, Phalipon A, Sansonetti PJ, Goldberg MB, Starnbach MN (2011) Antigen-specific CD8(+) T cells fail to respond to Shigella flexneri. Infect Immun 79(5):2021\u20132030","journal-title":"Infect Immun"},{"issue":"9","key":"5_CR54","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1038\/emi.2013.58","volume":"2","author":"W Jin","year":"2013","unstructured":"Jin W, Dong C (2013) IL-17 cytokines in immunity and inflammation. Emerg Microbes Infect 2(9):e60","journal-title":"Emerg Microbes Infect"},{"issue":"6151","key":"5_CR55","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1240248","volume":"341","author":"N Kayagaki","year":"2013","unstructured":"Kayagaki N, Wong MT, Stowe IB, Ramani SR, Gonzalez LC, Akashi-Takamura S, Miyake K, Zhang J, Lee WP, Muszynski A, Forsberg LS, Carlson RW, Dixit VM (2013) Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341(6151):1246\u20131249","journal-title":"Science"},{"issue":"6","key":"5_CR56","doi-asserted-by":"crossref","first-page":"800","DOI":"10.4269\/ajtmh.1998.58.800","volume":"58","author":"K Khalil","year":"1998","unstructured":"Khalil K, Khan SR, Mazhar K, Kaijser B, Lindblom GB (1998) Occurrence and susceptibility to antibiotics of Shigella species in stools of hospitalized children with bloody diarrhea in Pakistan. Am J Trop Med Hyg 58(6):800\u2013803","journal-title":"Am J Trop Med Hyg"},{"issue":"11","key":"5_CR57","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1016\/j.molimm.2008.02.013","volume":"45","author":"DW Kim","year":"2008","unstructured":"Kim DW, Chu H, Joo DH, Jang MS, Choi JH, Park SM, Choi YJ, Han SH, Yun CH (2008) OspF directly attenuates the activity of extracellular signal-regulated kinase during invasion by Shigella flexneri in human dendritic cells. Mol Immunol 45(11):3295\u20133301","journal-title":"Mol Immunol"},{"issue":"41","key":"5_CR58","doi-asserted-by":"crossref","first-page":"17733","DOI":"10.1073\/pnas.1006098107","volume":"107","author":"LA Knodler","year":"2010","unstructured":"Knodler LA, Vallance BA, Celli J, Winfree S, Hansen B, Montero M, Steele-Mortimer O (2010) Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia. Proc Natl Acad Sci USA 107(41):17733\u201317738","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"5_CR59","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2014.07.002","volume":"16","author":"LA Knodler","year":"2014","unstructured":"Knodler LA, Crowley SM, Sham HP, Yang H, Wrande M, Ma C, Ernst RK, Steele-Mortimer O, Celli J, Vallance BA (2014) Noncanonical inflammasome activation of caspase-4\/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host Microbe 16(2):249\u2013256","journal-title":"Cell Host Microbe"},{"issue":"5","key":"5_CR60","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.chom.2013.04.012","volume":"13","author":"T Kobayashi","year":"2013","unstructured":"Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, Akakura R, Yoshida M, Kawalec M, Reichhart JM, Mizushima T, Sasakawa C (2013) The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe 13(5):570\u2013583","journal-title":"Cell Host Microbe"},{"issue":"7366","key":"5_CR61","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","volume":"477","author":"EM Kofoed","year":"2011","unstructured":"Kofoed EM, Vance RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477(7366):592\u2013595","journal-title":"Nature"},{"issue":"3","key":"5_CR62","doi-asserted-by":"crossref","first-page":"815","DOI":"10.4049\/jimmunol.1403100","volume":"195","author":"J Kortmann","year":"2015","unstructured":"Kortmann J, Brubaker SW, Monack DM (2015) Cutting edge: inflammasome activation in primary human macrophages is dependent on flagellin. J Immunol Author Choice 195(3):815\u2013819","journal-title":"J Immunol Author Choice"},{"issue":"8","key":"5_CR63","first-page":"651","volume":"77","author":"KL Kotloff","year":"1999","unstructured":"Kotloff KL, Winickoff JP, Ivanoff B, Clemens JD, Swerdlow DL, Sansonetti PJ, Adak GK, Levine MM (1999) Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ 77(8):651\u2013666","journal-title":"Bull World Health Organ"},{"issue":"9888","key":"5_CR64","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","volume":"382","author":"KL Kotloff","year":"2013","unstructured":"Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH, Panchalingam S, Wu Y, Sow SO, Sur D, Breiman RF, Faruque AS, Zaidi AK, Saha D, Alonso PL, Tamboura B, Sanogo D, Onwuchekwa U, Manna B, Ramamurthy T, Kanungo S, Ochieng JB, Omore R, Oundo JO, Hossain A, Das SK, Ahmed S, Qureshi S, Quadri F, Adegbola RA, Antonio M, Hossain MJ, Akinsola A, Mandomando I, Nhampossa T, Ac\u00e1cio S, Biswas K, O\u2019Reilly CE, Mintz ED, Berkeley LY, Muhsen K, Sommerfelt H, Robins-Browne RM, Levine MM (2013) Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the global enteric multicenter study, GEMS): a prospective, case-control study. Lancet 382(9888):209\u2013222","journal-title":"Lancet"},{"issue":"17","key":"5_CR65","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1093\/emboj\/cdf457","volume":"21","author":"F Lafont","year":"2002","unstructured":"Lafont F, Tran Van Nhieu G, Hanada K, Sansonetti P, van der Goot FG (2002) Initial steps of Shigella infection depend on the cholesterol\/sphingolipid raft-mediated CD44-IpaB interaction. EMBO J 21(17):4449\u20134457","journal-title":"EMBO J"},{"issue":"5","key":"5_CR66","doi-asserted-by":"crossref","first-page":"e20014","DOI":"10.1371\/journal.pone.0020014","volume":"6","author":"D Lasigli\u00e8","year":"2011","unstructured":"Lasigli\u00e8 D, Traggiai E, Federici S, Alessio M, Buoncompagni A, Accogli A, Chiesa S, Penco F, Martini A, Gattorno M (2011) Role of IL-1\u03b2 in the development of human T(H)17 cells: lesson from NLPR3 mutated patients. PLoS ONE 6(5):e20014","journal-title":"PLoS ONE"},{"key":"5_CR67","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1038\/cddis.2011.4","volume":"2","author":"L Lembo-Fazio","year":"2011","unstructured":"Lembo-Fazio L, Nigro G, No\u00ebl G, Rossi G, Chiara F, Tsilingiri K, Rescigno M, Rasola A, Bernardini ML (2011) Gadd45\u03b1 activity is the principal effector of Shigella mitochondria-dependent epithelial cell death in vitro and ex vivo. Cell Death Dis 2:e122","journal-title":"Cell Death Dis"},{"issue":"51","key":"5_CR68","doi-asserted-by":"crossref","first-page":"39920","DOI":"10.1074\/jbc.M007255200","volume":"275","author":"XY Lin","year":"2000","unstructured":"Lin XY, Choi MSK, Porter AG (2000) Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-\u03b3. J Biol Chem 275(51):39920\u201339926","journal-title":"J Biol Chem"},{"issue":"20","key":"5_CR69","doi-asserted-by":"crossref","first-page":"16955","DOI":"10.1074\/jbc.M112.358705","volume":"287","author":"Z Liu","year":"2012","unstructured":"Liu Z, Zaki MH, Vogel P, Gurung P, Finlay BB, Deng W, Lamkanfi M, Kanneganti TD (2012) Role of inflammasomes in host defense against Citrobacter rodentium infection. J Biol Chem 287(20):16955\u201316964","journal-title":"J Biol Chem"},{"issue":"1","key":"5_CR70","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1128\/IAI.65.1.110-115.1997","volume":"65","author":"I Mandic-Mulec","year":"1997","unstructured":"Mandic-Mulec I, Weiss J, Zychlinsky A (1997) Shigella flexneri is trapped in polymorphonuclear leukocyte vacuoles and efficiently killed. Infect Immun 65(1):110\u2013115","journal-title":"Infect Immun"},{"issue":"7","key":"5_CR71","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1128\/IAI.64.7.2474-2482.1996","volume":"64","author":"N Mantis","year":"1996","unstructured":"Mantis N, Pr\u00e9vost MC, Sansonetti P (1996) Analysis of epithelial cell stress response during infection by Shigella flexneri. Infect Immun 64(7):2474\u20132482","journal-title":"Infect Immun"},{"issue":"6996","key":"5_CR72","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","volume":"430","author":"S Mariathasan","year":"2004","unstructured":"Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430(6996):213\u2013218","journal-title":"Nature"},{"issue":"2","key":"5_CR73","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2. Mol Cell 10(2):417\u2013426","journal-title":"Mol Cell"},{"issue":"1","key":"5_CR74","first-page":"25","volume":"123","author":"MM Mathan","year":"1986","unstructured":"Mathan MM, Mathan VI (1986) Ultrastructural pathology of the rectal mucosa in Shigella dysentery. Am J Pathol 123(1):25\u201338","journal-title":"Am J Pathol"},{"issue":"Suppl 4","key":"5_CR75","doi-asserted-by":"crossref","first-page":"S314","DOI":"10.1093\/clinids\/13.Supplement_4.S314","volume":"13","author":"MM Mathan","year":"1991","unstructured":"Mathan MM, Mathan VI (1991) Morphology of rectal mucosa of patients with shigellosis. Rev Infect Dis 13(Suppl 4):S314\u2013S318","journal-title":"Rev Infect Dis"},{"issue":"18","key":"5_CR76","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1128\/jb.175.18.5899-5906.1993","volume":"175","author":"R M\u00e9nard","year":"1993","unstructured":"M\u00e9nard R, Sansonetti PJ, Parsot C (1993) Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J Bacteriol 175(18):5899\u20135906","journal-title":"J Bacteriol"},{"issue":"12","key":"5_CR77","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","volume":"11","author":"EA Miao","year":"2010","unstructured":"Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A (2010a) Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 11(12):1136\u20131142","journal-title":"Nat Immunol"},{"issue":"7","key":"5_CR78","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1073\/pnas.0913087107","volume":"107","author":"EA Miao","year":"2010","unstructured":"Miao EA, Mao DP, Yudkovsky N, Bonneau R, Lorang CG, Warren SE, Leaf IA, Aderem A (2010b) Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci USA 107(7):3076\u20133080","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"5_CR79","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01044.x","volume":"243","author":"EA Miao","year":"2011","unstructured":"Miao EA, Rajan JV, Aderem A (2011) Caspase-1-induced pyroptotic cell death. Immunol Rev 243(1):206\u2013214","journal-title":"Immunol Rev"},{"issue":"10","key":"5_CR80","doi-asserted-by":"crossref","first-page":"6933","DOI":"10.4049\/jimmunol.179.10.6933","volume":"179","author":"LS Miller","year":"2007","unstructured":"Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O\u2019Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL (2007) Inflammasome-mediated production of IL-1\u03b2 is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol 179(10):6933\u20136942","journal-title":"J Immunol"},{"issue":"9","key":"5_CR81","doi-asserted-by":"crossref","first-page":"e1003588","DOI":"10.1371\/journal.ppat.1003588","volume":"9","author":"S Mostowy","year":"2013","unstructured":"Mostowy S, Boucontet L, Mazon Moya MJ, Sirianni A, Boudinot P, Hollinshead M, Cossart P, Herbomel P, Levraud JP, Colucci-Guyon E (2013) The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy. PLoS Pathog 9(9):e1003588","journal-title":"PLoS Pathog"},{"issue":"19","key":"5_CR82","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1093\/emboj\/cdf522","volume":"21","author":"K Niebuhr","year":"2002","unstructured":"Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B (2002) Conversion of PtdIns(4, 5)P(2) into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology. EMBO J 21(19):5069\u20135078","journal-title":"EMBO J"},{"issue":"3","key":"5_CR83","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1462-5822.2007.01075.x","volume":"10","author":"G Nigro","year":"2008","unstructured":"Nigro G, Fazio LL, Martino MC, Rossi G, Tattoli I, Liparoti V, De Castro C, Molinaro A, Philpott DJ, Bernardini ML (2008) Muramylpeptide shedding modulates cell sensing of Shigella flexneri. Cell Microbiol 10(3):682\u2013695","journal-title":"Cell Microbiol"},{"issue":"1","key":"5_CR84","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1574-6968.1999.tb13553.x","volume":"174","author":"T Nonaka","year":"1999","unstructured":"Nonaka T, Kuwae A, Sasakawa C, Imajoh-Ohmi S (1999) Shigella flexneri YSH6000 induces two types of cell death, apoptosis and oncosis, in the differentiated human monoblastic cell line U937. FEMS Microbiol Lett 174(1):89\u201395","journal-title":"FEMS Microbiol Lett"},{"issue":"4","key":"5_CR85","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/mi.2013.95","volume":"7","author":"S Nordlander","year":"2014","unstructured":"Nordlander S, Pott J, Maloy KJ (2014) NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen. Mucosal Immunol 7(4):775\u2013785","journal-title":"Mucosal Immunol"},{"issue":"6","key":"5_CR86","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1084\/jem.20130914","volume":"211","author":"K Nothelfer","year":"2014","unstructured":"Nothelfer K, Arena ET, Pinaud L, Neunlist M, Mozeleski B, Belotserkovsky I, Parsot C, Dinadayala P, Burger-Kentischer A, Raqib R, Sansonetti PJ, Phalipon A (2014) B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection. J Exp Med 211(6):1215\u20131229","journal-title":"J Exp Med"},{"issue":"12","key":"5_CR87","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.4049\/jimmunol.171.12.6329","volume":"171","author":"W O\u2019Connor Jr","year":"2003","unstructured":"O\u2019Connor W Jr, Harton JA, Zhu X, Linhoff MW, Ting JP (2003) Cutting edge: CIAS1\/cryopyrin\/PYPAF1\/NALP3\/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-\u03baB suppressive properties. J Immunol 171(12):6329\u20136333","journal-title":"J Immunol"},{"issue":"3","key":"5_CR88","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03240.x","volume":"129","author":"RM Onishi","year":"2010","unstructured":"Onishi RM, Gaffen SL (2010) Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 129(3):311\u2013321","journal-title":"Immunology"},{"issue":"9","key":"5_CR89","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.vaccine.2006.11.012","volume":"25","author":"M Osorio","year":"2007","unstructured":"Osorio M, Bray MD, Walker RI (2007) Vaccine potential for inactivated shigellae. Vaccine 25(9):1581\u20131592","journal-title":"Vaccine"},{"issue":"4","key":"5_CR90","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.4049\/jimmunol.167.4.1857","volume":"167","author":"NC Ottoson","year":"2001","unstructured":"Ottoson NC, Pribila JT, Chan ASH, Shimizu Y (2001) Cutting edge: T cell migration regulated by CXCR4 chemokine receptor signaling to ZAP-70 tyrosine kinase. J Immunol 167(4):1857\u20131861","journal-title":"J Immunol"},{"issue":"46","key":"5_CR91","doi-asserted-by":"crossref","first-page":"E4345","DOI":"10.1073\/pnas.1303641110","volume":"110","author":"I Paciello","year":"2013","unstructured":"Paciello I, Silipo A, Lembo-Fazio L, Curcur\u00f9 L, Zumsteg A, No\u00ebl G, Ciancarella V, Sturiale L, Molinaro A, Bernardini ML (2013) Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation. Proc Natl Acad Sci USA 110(46):E4345\u2013E4354","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"5_CR92","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mib.2008.12.002","volume":"12","author":"C Parsot","year":"2009","unstructured":"Parsot C (2009) Shigella type III secretion effectors: how, where, when, for what purposes? Curr Opin Microbiol 12(1):110\u2013116","journal-title":"Curr Opin Microbiol"},{"issue":"7466","key":"5_CR93","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature12524","volume":"501","author":"JS Pearson","year":"2013","unstructured":"Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TW, Mansell A, Riedmaier P, Oates CV, Zaid A, M\u00fchlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O\u2019Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland EL (2013) A type III effector antagonizes death receptor signalling during bacterial gut infection. Nature 501(7466):247\u2013251","journal-title":"Nature"},{"issue":"36","key":"5_CR94","doi-asserted-by":"crossref","first-page":"33878","DOI":"10.1074\/jbc.M303749200","volume":"278","author":"T P\u00e9dron","year":"2003","unstructured":"P\u00e9dron T, Thibault C, Sansonetti PJ (2003) The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco-2. J Biol Chem 278(36):33878\u201333886","journal-title":"J Biol Chem"},{"issue":"5","key":"5_CR95","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/sj.emboj.7601001","volume":"25","author":"C Pendaries","year":"2006","unstructured":"Pendaries C, Tronch\u00e8re H, Arbibe L, Mounier J, Gozani O, Cantley L, Fry MJ, Gaits-Iacovoni F, Sansonetti PJ, Payrastre B (2006) PtdIns5P activates the host cell PI3-kinase\/Akt pathway during Shigella flexneri infection. EMBO J 25(5):1024\u20131034","journal-title":"EMBO J"},{"issue":"2","key":"5_CR96","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4049\/jimmunol.165.2.903","volume":"165","author":"DJ Philpott","year":"2000","unstructured":"Philpott DJ, Yamaoka S, Isra\u00ebl A, Sansonetti PJ (2000) Invasive Shigella flexneri activates NF-\u03baB through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells. J Immunol 165(2):903\u2013914","journal-title":"J Immunol"},{"issue":"2","key":"5_CR97","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1095\/biolreprod.114.124420","volume":"92","author":"P Presicce","year":"2015","unstructured":"Presicce P, Senthamaraikannan P, Alvarez M, Rueda CM, Cappelletti M, Miller LA, Jobe AH, Chougnet CA, Kallapur SG (2015) Neutrophil recruitment and activation in decidua with intra-amniotic IL-1\u03b2 in the preterm rhesus macaque. Biol Reprod 92(2):56","journal-title":"Biol Reprod"},{"issue":"6","key":"5_CR98","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.immuni.2013.11.013","volume":"39","author":"A Puhar","year":"2013","unstructured":"Puhar A, Tronch\u00e8re H, Payrastre B, Nhieu GT, Sansonetti PJ (2013) A Shigella effector dampens inflammation by regulating epithelial release of danger signal ATP through production of the lipid mediator PtdIns5P. Immunity 39(6):1121\u20131131","journal-title":"Immunity"},{"issue":"1","key":"5_CR99","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1128\/IAI.63.1.289-296.1995","volume":"63","author":"R Raqib","year":"1995","unstructured":"Raqib R, Lindberg AA, Wretlind B, Bardhan PK, Andersson U, Andersson J (1995a) Persistence of local cytokine production in shigellosis in acute and convalescent stages. Infect Immun 63(1):289\u2013296","journal-title":"Infect Immun"},{"issue":"2","key":"5_CR100","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/infdis\/171.2.376","volume":"171","author":"R Raqib","year":"1995","unstructured":"Raqib R, Wretlind B, Andersson J, Lindberg AA (1995b) Cytokine secretion in acute shigellosis is correlated to disease activity and directed more to stool than to plasma. J Infect Dis 171(2):376\u2013384","journal-title":"J Infect Dis"},{"issue":"6","key":"5_CR101","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1128\/IAI.70.6.3199-3207.2002","volume":"70","author":"R Raqib","year":"2002","unstructured":"Raqib R, Ekberg C, Sharkar P, Bardhan PK, Zychlinsky A, Sansonetti PJ, Andersson J (2002a) Apoptosis in acute shigellosis is associated with increased production of Fas\/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2. Infect Immun 70(6):3199\u20133207","journal-title":"Infect Immun"},{"issue":"4","key":"5_CR102","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1046\/j.1365-3083.2002.01079.x","volume":"55","author":"R Raqib","year":"2002","unstructured":"Raqib R, Qadri F, SarkEr P, Mia SM, Sansonnetti PJ, Albert MJ, Andersson J (2002b) Delayed and reduced adaptive humoral immune responses in children with shigellosis compared with in adults. Scand J Immunol 55(4):414\u2013423","journal-title":"Scand J Immunol"},{"issue":"2","key":"5_CR103","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/clinids\/15.2.346","volume":"15","author":"JB Robbins","year":"1992","unstructured":"Robbins JB, Chu C, Schneerson R (1992) Hypothesis for vaccine development: protective immunity to enteric diseases caused by nontyphoidal salmonellae and shigellae may be conferred by serum IgG antibodies to the O-specific polysaccharide of their lipopolysaccharides. Clin Infect Dis 15(2):346\u2013361","journal-title":"Clin Infect Dis"},{"issue":"1","key":"5_CR104","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chom.2007.02.002","volume":"1","author":"JR Rohde","year":"2007","unstructured":"Rohde JR, Breitkreutz A, Chenal A, Sansonetti PJ, Parsot C (2007) Type III secretion effectors of the IpaH family are E3 ubiquitin ligases. Cell Host Microbe 1(1):77\u201383","journal-title":"Cell Host Microbe"},{"issue":"12","key":"5_CR105","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1073\/pnas.1300981110","volume":"110","author":"W Salgado-Pabon","year":"2013","unstructured":"Salgado-Pabon W, Celli S, Arena ET, Nothelfer K, Roux P, Sellge G, Frigimelica E, Bousso P, Sansonetti PJ, Phalipon A (2013) Shigella impairs T lymphocyte dynamics in vivo. Proc Natl Acad Sci USA 110(12):4458\u20134463","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"5_CR106","doi-asserted-by":"crossref","first-page":"G319","DOI":"10.1152\/ajpgi.2001.280.3.G319","volume":"280","author":"PJ Sansonetti","year":"2001","unstructured":"Sansonetti PJ (2001a) III. Shigellosis: from symptoms to molecular pathogenesis. Am J Physiol Gastrointest Liver Physiol 280(3):G319\u2013G323","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"5_CR107","first-page":"3","volume":"25","author":"PJ Sansonetti","year":"2001","unstructured":"Sansonetti PJ (2001b) Rupture, invasion and inflammatory destruction of the intestinal barrier by Shigella, making sense of prokaryote-eukaryote cross-talks. FEMS Microbiol Rev 25(1):3\u201314","journal-title":"FEMS Microbiol Rev"},{"issue":"1","key":"5_CR108","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/IAI.34.1.75-83.1981","volume":"34","author":"PJ Sansonetti","year":"1981","unstructured":"Sansonetti PJ, Kopecko DJ, Formal SB (1981) Shigella sonnei plasmids: evidence that a large plasmid is necessary for virulence. Infect Immun 34(1):75\u201383","journal-title":"Infect Immun"},{"issue":"3","key":"5_CR109","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/IAI.35.3.852-860.1982","volume":"35","author":"PJ Sansonetti","year":"1982","unstructured":"Sansonetti PJ, Kopecko DJ, Formal SB (1982) Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect Immun 35(3):852\u2013860","journal-title":"Infect Immun"},{"issue":"3","key":"5_CR110","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1128\/IAI.39.3.1392-1402.1983","volume":"39","author":"PJ Sansonetti","year":"1983","unstructured":"Sansonetti PJ, Hale TL, Dammin GJ, Kapfer C, Collins HH Jr, Formal SB (1983) Alterations in the pathogenicity of Escherichia coli K-12 after transfer of plasmid and chromosomal genes from Shigella flexneri. Infect Immun 39(3):1392\u20131402","journal-title":"Infect Immun"},{"issue":"2","key":"5_CR111","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1128\/IAI.51.2.461-469.1986","volume":"51","author":"PJ Sansonetti","year":"1986","unstructured":"Sansonetti PJ, Ryter A, Clerc P, Maurelli AT, Mounier J (1986) Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis. Infect Immun 51(2):461\u2013469","journal-title":"Infect Immun"},{"issue":"6","key":"5_CR112","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/0264-410X(91)90128-S","volume":"9","author":"PJ Sansonetti","year":"1991","unstructured":"Sansonetti PJ, Arondel J, Fontaine A, d\u2019Hauteville H, Bernardini ML (1991) OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis. Vaccine 9(6):416\u2013422","journal-title":"Vaccine"},{"issue":"2","key":"5_CR113","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1172\/JCI118135","volume":"96","author":"PJ Sansonetti","year":"1995","unstructured":"Sansonetti PJ, Arondel J, Cavaillon JM, Huerre M (1995) Role of interleukin-1 in the pathogenesis of experimental shigellosis. J Clin Invest 96(2):884\u2013892","journal-title":"J Clin Invest"},{"issue":"3","key":"5_CR114","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1128\/IAI.67.3.1471-1480.1999","volume":"67","author":"PJ Sansonetti","year":"1999","unstructured":"Sansonetti PJ, Arondel J, Huerre M, Harada A, Matsushima K (1999) Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis. Infect Immun 67(3):1471\u20131480","journal-title":"Infect Immun"},{"issue":"5","key":"5_CR115","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1074-7613(00)80209-5","volume":"12","author":"PJ Sansonetti","year":"2000","unstructured":"Sansonetti PJ, Phalipon A, Arondel J, Thirumalai K, Banerjee S, Akira S, Takeda K, Zychlinsky A (2000) Caspase-1 activation of IL-1\u03b2 and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity 12(5):581\u2013590","journal-title":"Immunity"},{"issue":"44","key":"5_CR116","doi-asserted-by":"crossref","first-page":"41624","DOI":"10.1074\/jbc.M207852200","volume":"277","author":"R Schauvliege","year":"2002","unstructured":"Schauvliege R, Vanrobaeys J, Schotte P, Beyaert R (2002) Caspase-11 gene expression in response to lipopolysaccharide and interferon-\u03b3 requires nuclear factor-\u03baB and signal transducer and activator of transcription (STAT) 1. J Biol Chem 277(44):41624\u201341630","journal-title":"J Biol Chem"},{"issue":"1","key":"5_CR117","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1462-5822.2006.00787.x","volume":"9","author":"GN Schroeder","year":"2007","unstructured":"Schroeder GN, Hilbi H (2007) Cholesterol is required to trigger caspase-1 activation and macrophage apoptosis after phagosomal escape of Shigella. Cell Microbiol 9(1):265\u2013278","journal-title":"Cell Microbiol"},{"issue":"4","key":"5_CR118","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.4049\/jimmunol.0900978","volume":"184","author":"G Sellge","year":"2010","unstructured":"Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A (2010) Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity. J Immunol 184(4):2076\u20132085","journal-title":"J Immunol"},{"issue":"2","key":"5_CR119","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","volume":"16","author":"ME Sellin","year":"2014","unstructured":"Sellin ME, M\u00fcller AA, Felmy B, Dolowschiak T, Diard M, Tardivel A, Maslowski KM, Hardt WD (2014) Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. Cell Host Microbe 16(2):237\u2013248","journal-title":"Cell Host Microbe"},{"key":"5_CR120","doi-asserted-by":"crossref","first-page":"e384","DOI":"10.1038\/cddis.2012.124","volume":"3","author":"L Senerovic","year":"2012","unstructured":"Senerovic L, Tsunoda SP, Goosmann C, Brinkmann V, Zychlinsky A, Meissner F, Kolbe M (2012) Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages. Cell Death Dis 3:e384","journal-title":"Cell Death Dis"},{"issue":"35","key":"5_CR121","doi-asserted-by":"crossref","first-page":"9301","DOI":"10.1523\/JNEUROSCI.1418-07.2007","volume":"27","author":"SS Shaftel","year":"2007","unstructured":"Shaftel SS, Carlson T, Olschowka JA, Kyrkanides S, Matousek SB, O\u2019Banion MK (2007) Chronic interleukin-1\u03b2 expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood-brain barrier permeability without overt neurodegeneration. J Neurosci 27(35):9301\u20139309","journal-title":"J Neurosci"},{"issue":"7521","key":"5_CR122","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","volume":"514","author":"J Shi","year":"2014","unstructured":"Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L, Shao F (2014) Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514(7521):187\u2013192","journal-title":"Nature"},{"issue":"4","key":"5_CR123","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bbrc.2010.09.100","volume":"401","author":"DH Shim","year":"2010","unstructured":"Shim DH, Ryu S, Kweon MN (2010) Defensins play a crucial role in protecting mice against oral Shigella flexneri infection. Biochem Biophys Res Commun 401(4):554\u2013560","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"5_CR124","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.4049\/jimmunol.173.6.4197","volume":"173","author":"M Singer","year":"2004","unstructured":"Singer M, Sansonetti PJ (2004) IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis. J Immunol 173(6):4197\u20134206","journal-title":"J Immunol"},{"issue":"5","key":"5_CR125","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1084\/jem.20071698","volume":"205","author":"B Sperandio","year":"2008","unstructured":"Sperandio B, Regnault B, Guo J, Zhang Z, Stanley SL Jr, Sansonetti PJ, Pedron T (2008) Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression. J Exp Med 205(5):1121\u20131132","journal-title":"J Exp Med"},{"issue":"14","key":"5_CR126","doi-asserted-by":"crossref","first-page":"14042","DOI":"10.1074\/jbc.M414671200","volume":"280","author":"T Suzuki","year":"2005","unstructured":"Suzuki T, Nakanishi K, Tsutsui H, Iwai H, Akira S, Inohara N, Chamaillard M, Nu\u00f1ez G, Sasakawa C (2005) A novel caspase-1\/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages. J Biol Chem 280(14):14042\u201314050","journal-title":"J Biol Chem"},{"issue":"8","key":"5_CR127","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1371\/journal.ppat.0030111","volume":"3","author":"T Suzuki","year":"2007","unstructured":"Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, Nu\u00f1ez G (2007) Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog 3(8):e111","journal-title":"PLoS Pathog"},{"issue":"2","key":"5_CR128","doi-asserted-by":"crossref","first-page":"e1003926","DOI":"10.1371\/journal.ppat.1003926","volume":"10","author":"S Suzuki","year":"2014","unstructured":"Suzuki S, Franchi L, He Y, Mu\u00f1oz-Planillo R, Mimuro H, Suzuki T, Sasakawa C, N\u00fa\u00f1ez G (2014a) Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkc\u03b4. PLoS Pathog 10(2):e1003926","journal-title":"PLoS Pathog"},{"issue":"40","key":"5_CR129","doi-asserted-by":"crossref","first-page":"E4254","DOI":"10.1073\/pnas.1324021111","volume":"111","author":"S Suzuki","year":"2014","unstructured":"Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M, Sanada T, Suzuki T, Tsutsui H, N\u00fa\u00f1ez G, Sasakawa C (2014b) Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc Natl Acad Sci USA 111(40):E4254\u2013E4263","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"5_CR130","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/sj.embor.7401161","volume":"9","author":"I Tattoli","year":"2008","unstructured":"Tattoli I, Carneiro LA, J\u00e9hanno M, Magalhaes JG, Shu Y, Philpott DJ, Arnoult D, Girardin SE (2008) NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-\u03baB and JNK pathways by inducing reactive oxygen species production. EMBO Rep 9(3):293\u2013300","journal-title":"EMBO Rep"},{"issue":"12","key":"5_CR131","doi-asserted-by":"crossref","first-page":"e82601","DOI":"10.1371\/journal.pone.0082601","volume":"8","author":"AI Ud-Din","year":"2013","unstructured":"Ud-Din AI, Wahid SU, Latif HA, Shahnaij M, Akter M, Azmi IJ, Hasan TN, Ahmed D, Hossain MA, Faruque AS, Faruque SM, Talukder KA (2013) Changing trends in the prevalence of Shigella species: emergence of multi-drug resistant Shigella sonnei biotype g in Bangladesh. PLoS ONE 8(12):e82601","journal-title":"PLoS ONE"},{"issue":"7","key":"5_CR132","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/eji.1830180728","volume":"18","author":"JW Van\u2019t Wout","year":"1988","unstructured":"Van\u2019t Wout JW, Van der Meer JW, Barza M, Dinarello CA (1988) Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1. Eur J Immunol 18(7):1143\u20131146","journal-title":"Eur J Immunol"},{"key":"5_CR133","first-page":"439","volume":"11","author":"MV Voino-Yasenetsky","year":"1962","unstructured":"Voino-Yasenetsky MV, Voino-Yasenetskaya MK (1962) Experimental pneumonia caused by bacteria of the Shigella group. Acta Morphol Acad Sci Hung 11:439\u2013454","journal-title":"Acta Morphol Acad Sci Hung"},{"issue":"3","key":"5_CR134","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1128\/IAI.57.3.858-863.1989","volume":"57","author":"JS Wassef","year":"1989","unstructured":"Wassef JS, Keren DF, Mailloux JL (1989) Role of M cells in initial antigen uptake and in ulcer formation in the rabbit intestinal loop model of shigellosis. Infect Immun 57(3):858\u2013863","journal-title":"Infect Immun"},{"issue":"6884","key":"5_CR135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/417091a","volume":"417","author":"Y Weinrauch","year":"2002","unstructured":"Weinrauch Y, Drujan D, Shapiro SD, Weiss J, Zychlinsky A (2002) Neutrophil elastase targets virulence factors of enterobacteria. Nature 417(6884):91\u201394","journal-title":"Nature"},{"issue":"35","key":"5_CR136","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1073\/pnas.1306376110","volume":"110","author":"J Yang","year":"2013","unstructured":"Yang J, Zhao Y, Shi J, Shao F (2013) Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc Natl Acad Sci USA 110(35):14408\u201314413","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"5_CR137","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.resmic.2015.06.007","volume":"166","author":"G Yang","year":"2015","unstructured":"Yang G, Wang L, Wang Y, Li P, Zhu J, Qiu S, Hao R, Wu Z, Li W, Song H (2015) hfq regulates acid tolerance and virulence by responding to acid stress in Shigella flexneri. Res Microbiol 166(6):476\u2013485","journal-title":"Res Microbiol"},{"issue":"6","key":"5_CR138","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ijid.2008.10.005","volume":"13","author":"A Zafar","year":"2009","unstructured":"Zafar A, Hasan R, Nizami SQ, von Seidlein L, Soofi S, Ahsan T, Chandio S, Habib A, Bhutto N, Siddiqui FJ, Rizvi A, Clemens JD, Bhutta ZA (2009) Frequency of isolation of various subtypes and antimicrobial resistance of Shigella from urban slums of Karachi. Pakistan. Int J Infect Dis 13(6):668\u2013672","journal-title":"Pakistan. Int J Infect Dis"},{"issue":"5","key":"5_CR139","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1128\/IAI.69.5.3240-3247.2001","volume":"69","author":"Z Zhang","year":"2001","unstructured":"Zhang Z, Jin L, Champion G, Seydel KB, Stanley SL (2001) Shigella infection in a SCID mouse-human intestinal xenograft model: role for neutrophils in containing bacterial dissemination in human intestine. Infect Immun 69(5):3240\u20133247","journal-title":"Infect Immun"},{"issue":"7366","key":"5_CR140","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature10510","volume":"477","author":"Y Zhao","year":"2011","unstructured":"Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F (2011) The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477(7366):596\u2013600","journal-title":"Nature"},{"issue":"6382","key":"5_CR141","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/358167a0","volume":"358","author":"A Zychlinsky","year":"1992","unstructured":"Zychlinsky A, Prevost MC, Sansonetti PJ (1992) Shigella flexneri induces apoptosis in infected macrophages. Nature 358(6382):167\u2013169","journal-title":"Nature"},{"issue":"3","key":"5_CR142","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1172\/JCI117452","volume":"94","author":"A Zychlinsky","year":"1994","unstructured":"Zychlinsky A, Fitting C, Cavaillon JM, Sansonetti PJ (1994a) Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri. J Clin Invest 94(3):1328\u20131332","journal-title":"J Clin Invest"},{"issue":"4","key":"5_CR143","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2958.1994.tb00341.x","volume":"11","author":"A Zychlinsky","year":"1994","unstructured":"Zychlinsky A, Kenny B, M\u00e9nard R, Pr\u00e9vost MC, Holland IB, Sansonetti PJ (1994b) IpaB mediates macrophage apoptosis induced by Shigella flexneri. Mol Microbiol 11(4):619\u2013627","journal-title":"Mol Microbiol"}],"container-title":["Current Topics in Microbiology and Immunology","Inflammasome Signaling and Bacterial Infections"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-41171-2_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T16:50:03Z","timestamp":1656867003000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-41171-2_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9783319411705","9783319411712"],"references-count":143,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-41171-2_5","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}