{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:02:04Z","timestamp":1782698524984,"version":"3.54.5"},"publisher-location":"Cham","reference-count":62,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319413327","type":"print"},{"value":"9783319413341","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-3-319-41334-1_18","type":"book-chapter","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T07:48:39Z","timestamp":1474876119000},"page":"435-452","source":"Crossref","is-referenced-by-count":35,"title":["Garcinol and Its Role in Chronic Diseases"],"prefix":"10.1007","author":[{"given":"Amit K.","family":"Behera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadeva M.","family":"Swamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagashayana","family":"Natesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas K.","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,25]]},"reference":[{"issue":"7","key":"18_CR1","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.foodres.2011.01.064","volume":"44","author":"MS Baliga","year":"2011","unstructured":"Baliga MS, Bhat HP, Pai RJ et al (2011) The chemistry and medicinal uses of the underutilized Indian fruit tree Garcinia indica Choisy (kokum): a review. Food Res Intern 44(7):1790\u20131799","journal-title":"Food Res Intern"},{"key":"18_CR2","unstructured":"Charaka samhita text, suthrasthaana, chapter 4th and 27th, Bhava prakasha text"},{"key":"18_CR3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bioorg.2015.04.010","volume":"60","author":"CM Han","year":"2015","unstructured":"Han CM, Zhou XY, Cao J et al (2015) 13,14-Dihydroxy groups are critical for the anti-cancer effects of garcinol. Bioorg Chem 60:123\u2013129","journal-title":"Bioorg Chem"},{"key":"18_CR4","doi-asserted-by":"crossref","unstructured":"Mantelingu K, Reddy BA, Swaminathan V et al Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol 14(6):645\u201357","DOI":"10.1016\/j.chembiol.2007.04.011"},{"issue":"8","key":"18_CR5","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.freeradbiomed.2007.01.016","volume":"42","author":"J Hong","year":"2007","unstructured":"Hong J, Kwon SJ, Sang S et al (2007) Effects of garcinol and its derivatives on intestinal cell growth: inhibitory effects and autoxidation-dependent growth-stimulatory effects. Free Radic Biol Med 42(8):1211\u20131221","journal-title":"Free Radic Biol Med"},{"issue":"32","key":"18_CR6","doi-asserted-by":"crossref","first-page":"33716","DOI":"10.1074\/jbc.M402839200","volume":"279","author":"K Balasubramanyam","year":"2004","unstructured":"Balasubramanyam K, Altaf M, Varier RA et al (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem 279(32):33716\u201333726","journal-title":"J Biol Chem"},{"key":"18_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1446","author":"CC Huang","year":"2015","unstructured":"Huang CC, Lin CM, Huang YJ et al (2015) Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. Biotechnol Appl Biochem. doi: 10.1002\/bab.1446","journal-title":"Biotechnol Appl Biochem"},{"issue":"9","key":"18_CR8","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1002\/mnfr.201400149","volume":"58","author":"ML Tsai","year":"2014","unstructured":"Tsai ML, Chiou YS, Chiou LY et al (2014) Garcinol suppresses inflammation-associated colon carcinogenesis in mice. Mol Nutr Food Res 58(9):1820\u20131829","journal-title":"Mol Nutr Food Res"},{"key":"18_CR9","doi-asserted-by":"crossref","unstructured":"Yoshida K, Tanaka T, Hirose Y et al (2005) Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats. Cancer Lett 221(1):29\u201339","DOI":"10.1016\/j.canlet.2004.08.016"},{"issue":"12","key":"18_CR10","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1093\/carcin\/bgs290","volume":"33","author":"A Ahmad","year":"2012","unstructured":"Ahmad A, Sarkar SH, Aboukameel A et al (2012) Anti-cancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling. Carcinogenesis 33(12):2450\u20132456","journal-title":"Carcinogenesis"},{"key":"18_CR11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1476-4598-13-66","volume":"13","author":"G Sethi","year":"2014","unstructured":"Sethi G, Chatterjee S, Rajendran P et al (2014) Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo. Mol Cancer 13:66","journal-title":"Mol Cancer"},{"issue":"10","key":"18_CR12","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1158\/1535-7163.MCT-12-0232-T","volume":"11","author":"A Ahmad","year":"2012","unstructured":"Ahmad A, Sarkar SH, Bitar B et al (2012) Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Mol Cancer Ther 11(10):2193\u20132201","journal-title":"Mol Cancer Ther"},{"key":"18_CR13","first-page":"1483","volume":"3","author":"A Ahmad","year":"2011","unstructured":"Ahmad A, Wang Z, Wojewoda C et al (2011) Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling. Front Biosci (Elite Ed) 3:1483\u20131492","journal-title":"Front Biosci (Elite Ed)"},{"issue":"6","key":"18_CR14","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/jcb.22492","volume":"109","author":"A Ahmad","year":"2010","unstructured":"Ahmad A, Wang Z, Ali R et al (2010) Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. J Cell Biochem 109(6):1134\u20131141","journal-title":"J Cell Biochem"},{"issue":"3","key":"18_CR15","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1021\/jf001129v","volume":"49","author":"MH Pan","year":"2001","unstructured":"Pan MH, Chang WL, Lin-Shiau SY et al (2001) Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. J Agric Food Chem 49(3):1464\u20131474","journal-title":"J Agric Food Chem"},{"issue":"4","key":"18_CR16","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1158\/1535-7163.MCT-09-1113","volume":"9","author":"S Prasad","year":"2010","unstructured":"Prasad S, Ravindran J, Sung B et al (2010) Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins. Mol Cancer Ther 9(4):856\u2013868","journal-title":"Mol Cancer Ther"},{"issue":"3","key":"18_CR17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ijrobp.2012.01.017","volume":"84","author":"T Oike","year":"2012","unstructured":"Oike T, Ogiwara H, Torikai K et al (2012) Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining. Int J Radiat Oncol Biol Phys 84(3):815\u2013821","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"18_CR18","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1080\/01635581.2012.718032","volume":"64","author":"X Chen","year":"2012","unstructured":"Chen X, Zhang X, Lu Y et al (2012) Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol. Nutr Cancer 64(8):1211\u20131218","journal-title":"Nutr Cancer"},{"key":"18_CR19","doi-asserted-by":"crossref","unstructured":"Li F, Shanmugam MK, Chen L (2013) Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila) 6(8):843\u201354","DOI":"10.1158\/1940-6207.CAPR-13-0070"},{"key":"18_CR20","doi-asserted-by":"crossref","first-page":"709739","DOI":"10.1155\/2012\/709739","volume":"2012","author":"MA Parasramka","year":"2012","unstructured":"Parasramka MA, Gupta SV (2012) Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells. J Oncol 2012:709739","journal-title":"J Oncol"},{"issue":"3","key":"18_CR21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1039\/c0fo00134a","volume":"1","author":"AC Cheng","year":"2010","unstructured":"Cheng AC, Tsai ML, Liu CM et al (2010) Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food Funct 1(3):301\u2013307","journal-title":"Food Funct"},{"issue":"1","key":"18_CR22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jcb.20540","volume":"96","author":"CH Liao","year":"2005","unstructured":"Liao CH, Sang S, Ho CT et al (2005) Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. Cell Biochem 96(1):155\u2013169","journal-title":"Cell Biochem"},{"issue":"31","key":"18_CR23","doi-asserted-by":"crossref","first-page":"25869","DOI":"10.1074\/jbc.M112.375204","volume":"287","author":"CS Kadiyala","year":"2012","unstructured":"Kadiyala CS, Zheng L, Du Y et al (2012) Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC). J Biol Chem 287(31):25869\u201325880","journal-title":"J Biol Chem"},{"issue":"1","key":"18_CR24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbadis.2014.11.006","volume":"1852","author":"Y Wang","year":"2015","unstructured":"Wang Y, Wang Y, Luo M et al (2015) Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300\/CBP-mediated histone acetylation. Biochim Biophys Acta 1852(1):34\u201346","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"18_CR25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jnutbio.2010.03.014","volume":"22","author":"JM Yun","year":"2011","unstructured":"Yun JM, Jialal I, Devaraj S (2011) Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. J Nutr Biochem 22(5):450\u2013458","journal-title":"J Nutr Biochem"},{"issue":"12","key":"18_CR26","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.3390\/nu4121868","volume":"4","author":"TX Pham","year":"2012","unstructured":"Pham TX, Lee J (2012) Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases. Nutrients 4(12):1868\u20131886","journal-title":"Nutrients"},{"issue":"1","key":"18_CR27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1039\/C1FO10209E","volume":"3","author":"CL Hsu","year":"2012","unstructured":"Hsu CL, Lin YJ, Ho CT et al (2012) Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Food Funct 3(1):49\u201357","journal-title":"Food Funct"},{"issue":"2","key":"18_CR28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.yjmcc.2010.04.006","volume":"49","author":"EC Chan","year":"2010","unstructured":"Chan EC, Dusting GJ, Guo N et al (2010) Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation. J Mol Cell Cardiol 49(2):176\u2013185","journal-title":"J Mol Cell Cardiol"},{"issue":"21","key":"18_CR29","doi-asserted-by":"crossref","first-page":"19134","DOI":"10.1074\/jbc.M301580200","volume":"278","author":"K Balasubramanyam","year":"2003","unstructured":"Balasubramanyam K, Swaminathan V, Ranganathan A et al (2003) Small molecule modulators of histone acetyltransferase p300. J Biol Chem 278(21):19134\u201319140","journal-title":"J Biol Chem"},{"key":"18_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2015.03.012","volume":"113","author":"C Peng","year":"2015","unstructured":"Peng C, Zhang W, Zhao W, Zhu J, Huang X, Tian J (2015) Alcohol-induced histone H3K9 hyperacetylation and cardiac hypertrophy are reversed by a histone acetylases inhibitor anacardic acid in developing murine hearts. Biochimie 113:1\u20139","journal-title":"Biochimie"},{"issue":"1","key":"18_CR31","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/cbic.200400246","volume":"6","author":"SM Davidson","year":"2005","unstructured":"Davidson SM, Townsend PA, Carroll C et al (2005) The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. ChemBioChem 6(1):162\u2013170","journal-title":"ChemBioChem"},{"issue":"3","key":"18_CR32","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1021\/jf104263s","volume":"59","author":"MS Weng","year":"2011","unstructured":"Weng MS, Liao CH, Yu SY et al (2011) Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. J Agric Food Chem 59(3):1031\u20131040","journal-title":"J Agric Food Chem"},{"issue":"4","key":"18_CR33","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.bbrc.2005.02.110","volume":"329","author":"CH Liao","year":"2005","unstructured":"Liao CH, Ho CT, Lin JK (2005) Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes. Biochem Biophys Res Commun 329(4):1306\u20131314","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"18_CR34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/039463201302600210","volume":"26","author":"ZL Cui","year":"2013","unstructured":"Cui ZL, Gu W, Ding T et al (2013) Histone modifications of Notch1 promoter affect lung CD4+ T cell differentiation in asthmatic rats. Int J Immunopathol Pharmacol 26(2):371\u2013381","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"6","key":"18_CR35","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/carcin\/21.6.1183","volume":"21","author":"T Tanaka","year":"2000","unstructured":"Tanaka T, Kohno H, Shimada R et al (2000) Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats. Carcinogenesis 21(6):1183\u20131189","journal-title":"Carcinogenesis"},{"issue":"41","key":"18_CR36","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1021\/acs.jafc.5b03851","volume":"63","author":"Y Wang","year":"2015","unstructured":"Wang Y, Tsai ML, Chiou LY et al (2015) Antitumor activity of garcinol in human prostate cancer cells and xenograft mice. J Agric Food Chem 63(41):9047\u20139052","journal-title":"J Agric Food Chem"},{"issue":"18","key":"18_CR37","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1001\/jama.280.18.1596","volume":"280","author":"SB Heymsfield","year":"1998","unstructured":"Heymsfield SB, Allison DB, Vasselli JR et al (1998) Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 280(18):1596\u20131600","journal-title":"JAMA"},{"key":"18_CR38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1756-8722-2-38","volume":"2","author":"S Padhye","year":"2009","unstructured":"Padhye S, Ahmad A, Oswal N et al (2009) Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs. J Hematol Oncol 2:38","journal-title":"J Hematol Oncol"},{"issue":"7","key":"18_CR39","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.18632\/oncotarget.2881","volume":"6","author":"F Li","year":"2015","unstructured":"Li F, Shanmugam MK, Siveen KS et al (2015) Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers. Oncotarget 6(7):5147\u20135163","journal-title":"Oncotarget"},{"issue":"1","key":"18_CR40","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1186\/s13104-015-1596-8","volume":"8","author":"CA Pieme","year":"2015","unstructured":"Pieme CA, Ambassa P, Yankep E et al (2015) Epigarcinol and isogarcinol isolated from the root of Garcinia ovalifolia induce apoptosis of human promyelocytic leukemia (HL-60 cells). BMC Res Notes 8(1):700","journal-title":"BMC Res Notes"},{"issue":"18","key":"18_CR41","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1021\/jf405790q","volume":"62","author":"Y Fu","year":"2014","unstructured":"Fu Y, Zhou H, Wang M et al (2014) Immune regulation and anti-inflammatory effects of isogarcinol extracted from Garcinia mangostana L. against collagen-induced arthritis. J Agric Food Chem 62(18):4127\u20134134","journal-title":"J Agric Food Chem"},{"issue":"2","key":"18_CR42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/np020372g","volume":"66","author":"C Ito","year":"2003","unstructured":"Ito C, Itoigawa M, Miyamoto Y et al (2003) Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities. J Nat Prod 66(2):206\u2013209","journal-title":"J Nat Prod"},{"issue":"12","key":"18_CR43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1055\/s-0032-1327612","volume":"62","author":"Y Nu\u00f1ez-Figueredo","year":"2012","unstructured":"Nu\u00f1ez-Figueredo Y, Garc\u00eda-Pupo L, Ram\u00edrez-S\u00e1nchez J et al (2012) Neuroprotective action and free radical scavenging activity of guttiferone-A, a naturally occurring prenylatedbenzophenone. Arzneimittelforschung 62(12):583\u2013589","journal-title":"Arzneimittelforschung"},{"issue":"3","key":"18_CR44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.taap.2011.04.011","volume":"253","author":"GL Pardo-Andreu","year":"2011","unstructured":"Pardo-Andreu GL, Nu\u00f1ez-Figueredo Y, Tudella VG et al (2011) The anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: ensuing energetic and oxidative stress implications. Toxicol Appl Pharmacol 253(3):282\u2013289","journal-title":"Toxicol Appl Pharmacol"},{"issue":"11","key":"18_CR45","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00210-012-0788-1","volume":"385","author":"R Niero","year":"2012","unstructured":"Niero R, Dal Molin MM, Silva S et al (2012) Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice. Naunyn Schmiedebergs Arch Pharmacol 385(11):1103\u20131109","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"6","key":"18_CR46","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/ijc.27365","volume":"131","author":"C Feng","year":"2012","unstructured":"Feng C, Zhou LY, Yu T et al (2012) A new anticancer compound, oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. Int J Cancer 131(6):1445\u20131454","journal-title":"Int J Cancer"},{"key":"18_CR47","doi-asserted-by":"crossref","first-page":"10293","DOI":"10.1038\/srep10293","volume":"5","author":"X Wang","year":"2015","unstructured":"Wang X, Lao Y, Xu N et al (2015) Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins. Sci Rep 5:10293","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"18_CR48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11010-015-2444-9","volume":"406","author":"Y Lu","year":"2015","unstructured":"Lu Y, Cai S, Tan H et al (2015) Inhibitory effect of oblongifolin C on allergic inflammation through the suppression of mast cell activation. Mol Cell Biochem 406(1\u20132):263\u2013271","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"18_CR49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1248\/bpb.26.569","volume":"26","author":"K Matsumoto","year":"2003","unstructured":"Matsumoto K, Akao Y, Kobayashi E et al (2003) Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. Biol Pharm Bull 26(4):569\u2013571","journal-title":"Biol Pharm Bull"},{"issue":"10","key":"18_CR50","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.2174\/18715206113139990095","volume":"13","author":"LS Einbond","year":"2013","unstructured":"Einbond LS, Mighty J, Kashiwazaki R et al (2013) Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents Med Chem 13(10):1540\u20131550","journal-title":"Anticancer Agents Med Chem"},{"issue":"1","key":"18_CR51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/s12906-015-0911-1","volume":"15","author":"L Sales","year":"2015","unstructured":"Sales L, Pezuk JA, Borges KS et al (2015) Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma. BMC Complement Altern Med 15(1):393","journal-title":"BMC Complement Altern Med"},{"issue":"8","key":"18_CR52","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1021\/np100156w","volume":"73","author":"X Liu","year":"2010","unstructured":"Liu X, Yu T, Gao XM et al (2010) Apoptotic effects of polyprenylated benzoylphloroglucinol derivatives from the twigs of Garcinia multiflora. J Nat Prod 73(8):1355\u20131359","journal-title":"J Nat Prod"},{"issue":"1","key":"18_CR53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1568009613666131113100634","volume":"14","author":"LH Wang","year":"2014","unstructured":"Wang LH, Yang JY, Yang SN et al (2014) Suppression of NF-\u03baB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin-induced apoptosis in lung cancer. Curr Cancer Drug Targets 14(1):91\u2013103","journal-title":"Curr Cancer Drug Targets"},{"issue":"1","key":"18_CR54","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1158\/1078-0432.CCR-13-1063","volume":"20","author":"X Shi","year":"2014","unstructured":"Shi X, Chen X, Li X et al (2014) Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation. Clin Cancer Res 20(1):151\u2013163","journal-title":"Clin Cancer Res"},{"issue":"5","key":"18_CR55","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.3892\/ijo.2015.3166","volume":"47","author":"C Wen","year":"2015","unstructured":"Wen C, Huang L, Chen J et al (2015) Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells. Int J Oncol 47(5):1663\u20131671","journal-title":"Int J Oncol"},{"issue":"4","key":"18_CR56","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.2042-7158.1990.tb05412.x","volume":"42","author":"MM Iwu","year":"1990","unstructured":"Iwu MM, Igboko OA, Okunji CO et al (1990) Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola. J Pharm Pharmacol 42(4):290\u2013292","journal-title":"J Pharm Pharmacol"},{"key":"18_CR57","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12906-015-0760-y","volume":"15","author":"OR Oyenihi","year":"2015","unstructured":"Oyenihi OR, Brooks NL, Oguntibeju OO (2015) Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes. BMC Complement Altern Med 15:236","journal-title":"BMC Complement Altern Med"},{"key":"18_CR58","doi-asserted-by":"crossref","first-page":"919058","DOI":"10.1155\/2015\/919058","volume":"2015","author":"P Janhom","year":"2015","unstructured":"Janhom P, Dharmasaroja P (2015) Neuroprotective effects of Alpha-Mangostin on MPP(+)-induced apoptotic cell death in neuroblastoma SH-SY5Y cells. J Toxicol 2015:919058","journal-title":"J Toxicol"},{"issue":"5","key":"18_CR59","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1089\/ars.2013.5212","volume":"21","author":"BB Hafeez","year":"2014","unstructured":"Hafeez BB, Mustafa A, Fischer JW et al (2014) \u03b1-Mangostin: a dietary antioxidant derived from the pericarp of Garcinia mangostana L. inhibits pancreatic tumor growth in xenograft mouse model. Antioxid Redox Signal 21(5):682\u2013699","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"18_CR60","first-page":"3805","volume":"32","author":"JJ Wang","year":"2012","unstructured":"Wang JJ, Sanderson BJ, Zhang W (2012) Significant anti-invasive activities of \u03b1-mangostin from the mangosteen pericarp on two human skin cancer cell lines. Anticancer Res 32(9):3805\u20133816","journal-title":"Anticancer Res"},{"key":"18_CR61","doi-asserted-by":"crossref","unstructured":"Lu Y, Cai S, Nie J et al (2015) The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma. Biochem Pharmacol 100:61\u201372","DOI":"10.1016\/j.bcp.2015.11.004"},{"issue":"9","key":"18_CR62","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3760\/cma.j.issn.0366-6999.20122582","volume":"126","author":"Y Chi","year":"2013","unstructured":"Chi Y, Zhan XK, Yu H et al (2013) An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors. Chin Med J (Engl) 126(9):1642\u20131646","journal-title":"Chin Med J (Engl)"}],"container-title":["Advances in Experimental Medicine and Biology","Anti-inflammatory Nutraceuticals and Chronic Diseases"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-41334-1_18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T15:53:49Z","timestamp":1718812429000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-41334-1_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9783319413327","9783319413341"],"references-count":62,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-41334-1_18","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}