{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:58:34Z","timestamp":1783133914014,"version":"3.54.6"},"publisher-location":"Cham","reference-count":115,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319413860","type":"print"},{"value":"9783319413884","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-3-319-41388-4_10","type":"book-chapter","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T06:31:29Z","timestamp":1472452289000},"page":"183-212","source":"Crossref","is-referenced-by-count":27,"title":["Transcommitment: Paving the Way to Barrett\u2019s Metaplasia"],"prefix":"10.1007","author":[{"given":"David H.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda F.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"issue":"9","key":"10_CR1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJMra1314704","volume":"371","author":"SJ Spechler","year":"2014","unstructured":"Spechler SJ, Souza RF. Barrett\u2019s esophagus. N Engl J Med. 2014;371(9):836\u201345.","journal-title":"N Engl J Med"},{"issue":"3","key":"10_CR2","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1053\/j.gastro.2011.01.031","volume":"140","author":"SJ Spechler","year":"2011","unstructured":"Spechler SJ, Sharma P, Souza RF, Inadomi JM, Shaheen NJ. American Gastroenterological Association technical review on the management of Barrett\u2019s esophagus. Gastroenterology. 2011;140(3):e18\u201352. quiz e13.","journal-title":"Gastroenterology"},{"issue":"3","key":"10_CR3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1582-4934.2005.tb00489.x","volume":"9","author":"WC Li","year":"2005","unstructured":"Li WC, Yu WY, Quinlan JM, Burke ZD, Tosh D. The molecular basis of transdifferentiation. J Cell Mol Med. 2005;9(3):569\u201382.","journal-title":"J Cell Mol Med"},{"issue":"6","key":"10_CR4","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.gie.2014.12.029","volume":"81","author":"CC Cotton","year":"2015","unstructured":"Cotton CC, Wolf WA, Pasricha S, Li N, Madanick RD, Spacek MB, Ferrell K, Dellon ES, Shaheen NJ. Recurrent intestinal metaplasia after radiofrequency ablation for Barrett\u2019s esophagus: endoscopic findings and anatomic location. Gastrointest Endosc. 2015;81(6):1362\u20139.","journal-title":"Gastrointest Endosc"},{"issue":"1","key":"10_CR5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01296780","volume":"38","author":"HM Shields","year":"1993","unstructured":"Shields HM, Zwas F, Antonioli DA, Doos WG, Kim S, Spechler SJ. Detection by scanning electron microscopy of a distinctive esophageal surface cell at the junction of squamous and Barrett\u2019s epithelium. Dig Dis Sci. 1993;38(1):97\u2013108.","journal-title":"Dig Dis Sci"},{"issue":"6","key":"10_CR6","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/BF02088224","volume":"41","author":"RA Sawhney","year":"1996","unstructured":"Sawhney RA, Shields HM, Allan CH, Boch JA, Trier JS, Antonioli DA. Morphological characterization of the squamocolumnar junction of the esophagus in patients with and without Barrett\u2019s epithelium. Dig Dis Sci. 1996;41(6):1088\u201398.","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10_CR7","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1053\/gast.1997.v112.pm9041237","volume":"112","author":"JA Boch","year":"1997","unstructured":"Boch JA, Shields HM, Antonioli DA, Zwas F, Sawhney RA, Trier JS. Distribution of cytokeratin markers in Barrett\u2019s specialized columnar epithelium. Gastroenterology. 1997;112(3):760\u20135.","journal-title":"Gastroenterology"},{"issue":"5","key":"10_CR8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00000478-200105000-00002","volume":"25","author":"JN Glickman","year":"2001","unstructured":"Glickman JN, Chen YY, Wang HH, Antonioli DA, Odze RD. Phenotypic characteristics of a distinctive multilayered epithelium suggests that it is a precursor in the development of Barrett\u2019s esophagus. Am J Surg Pathol. 2001;25(5):569\u201378.","journal-title":"Am J Surg Pathol"},{"key":"10_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-230X-8-1","volume":"8","author":"X Chen","year":"2008","unstructured":"Chen X, Qin R, Liu B, Ma Y, Su Y, Yang CS, Glickman JN, Odze RD, Shaheen NJ. Multilayered epithelium in a rat model and human Barrett\u2019s esophagus: similar expression patterns of transcription factors and differentiation markers. BMC Gastroenterol. 2008;8:1.","journal-title":"BMC Gastroenterol"},{"issue":"6","key":"10_CR10","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/labinvest.3700079","volume":"84","author":"Y Su","year":"2004","unstructured":"Su Y, Chen X, Klein M, Fang M, Wang S, Yang CS, Goyal RK. Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett\u2019s esophagus. Lab Invest. 2004;84(6):753\u201365.","journal-title":"Lab Invest"},{"issue":"4","key":"10_CR11","doi-asserted-by":"crossref","first-page":"e18280","DOI":"10.1371\/journal.pone.0018280","volume":"6","author":"J Kong","year":"2011","unstructured":"Kong J, Crissey MA, Funakoshi S, Kreindler JL, Lynch JP. Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett\u2019s esophagus. PLoS One. 2011;6(4):e18280.","journal-title":"PLoS One"},{"issue":"2","key":"10_CR12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/carcin\/bgl176","volume":"28","author":"T Liu","year":"2007","unstructured":"Liu T, Zhang X, So CK, Wang S, Wang P, Yan L, Myers R, Chen Z, Patterson AP, Yang CS, et al. Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. Carcinogenesis. 2007;28(2):488\u201396.","journal-title":"Carcinogenesis"},{"issue":"5","key":"10_CR13","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1053\/j.gastro.2010.01.048","volume":"138","author":"DH Wang","year":"2010","unstructured":"Wang DH, Clemons NJ, Miyashita T, Dupuy AJ, Zhang W, Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Montgomery EA, Wang JS, et al. Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett\u2019s metaplasia. Gastroenterology. 2010;138(5):1810\u201322.","journal-title":"Gastroenterology"},{"issue":"10","key":"10_CR14","doi-asserted-by":"crossref","first-page":"e3534","DOI":"10.1371\/journal.pone.0003534","volume":"3","author":"DB Stairs","year":"2008","unstructured":"Stairs DB, Nakagawa H, Klein-Szanto A, Mitchell SD, Silberg DG, Tobias JW, Lynch JP, Rustgi AK. Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett\u2019s esophagus. PLoS One. 2008;3(10):e3534.","journal-title":"PLoS One"},{"issue":"1","key":"10_CR15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/carcin\/bgn227","volume":"30","author":"J Kong","year":"2009","unstructured":"Kong J, Nakagawa H, Isariyawongse BK, Funakoshi S, Silberg DG, Rustgi AK, Lynch JP. Induction of intestinalization in human esophageal keratinocytes is a multistep process. Carcinogenesis. 2009;30(1):122\u201330.","journal-title":"Carcinogenesis"},{"issue":"9","key":"10_CR16","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1172\/JCI66603","volume":"124","author":"DH Wang","year":"2014","unstructured":"Wang DH, Tiwari A, Kim ME, Clemons NJ, Regmi NL, Hodges WA, Berman DM, Montgomery EA, Watkins DN, Zhang X, et al. Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett\u2019s metaplasia. J Clin Invest. 2014;124(9):3767\u201380.","journal-title":"J Clin Invest"},{"issue":"1","key":"10_CR17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2010.03.035","volume":"139","author":"X Huo","year":"2010","unstructured":"Huo X, Zhang HY, Zhang XI, Lynch JP, Strauch ED, Wang JY, Melton SD, Genta RM, Wang DH, Spechler SJ, et al. Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett\u2019s esophagus. Gastroenterology. 2010;139(1):194\u2013203. e1.","journal-title":"Gastroenterology"},{"issue":"29","key":"10_CR18","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.3748\/wjg.v11.i29.4490","volume":"11","author":"G Hertogh De","year":"2005","unstructured":"De Hertogh G, Van Eyken P, Ectors N, Geboes K. On the origin of cardiac mucosa: a histological and immunohistochemical study of cytokeratin expression patterns in the developing esophagogastric junction region and stomach. World J Gastroenterol. 2005;11(29):4490\u20136.","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10_CR19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00000478-199103000-00010","volume":"15","author":"FG DeNardi","year":"1991","unstructured":"DeNardi FG, Riddell RH. The normal esophagus. Am J Surg Pathol. 1991;15(3):296\u2013309.","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10_CR20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ar.1092300210","volume":"230","author":"C Raymond","year":"1991","unstructured":"Raymond C, Anne V, Millane G. Development of esophageal epithelium in the fetal and neonatal mouse. Anat Rec. 1991;230(2):225\u201334.","journal-title":"Anat Rec"},{"issue":"3","key":"10_CR21","first-page":"309","volume":"39","author":"H Duan","year":"1993","unstructured":"Duan H, Gao F, Li S, Nagata T. Postnatal development and aging of esophageal epithelium in mouse: a light and electron microscopic radioautographic study. Cell Mol Biol (Noisy-le-Grand). 1993;39(3):309\u201316.","journal-title":"Cell Mol Biol (Noisy-le-Grand)"},{"issue":"1","key":"10_CR22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ydbio.2005.04.042","volume":"284","author":"WY Yu","year":"2005","unstructured":"Yu WY, Slack JM, Tosh D. Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus. Dev Biol. 2005;284(1):157\u201370.","journal-title":"Dev Biol"},{"issue":"3","key":"10_CR23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1667\/RR3224","volume":"162","author":"MW Epperly","year":"2004","unstructured":"Epperly MW, Guo H, Shen H, Niu Y, Zhang X, Jefferson M, Sikora CA, Greenberger JS. Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium. Radiat Res. 2004;162(3):233\u201340.","journal-title":"Radiat Res"},{"issue":"4","key":"10_CR24","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","volume":"183","author":"MA Goodell","year":"1996","unstructured":"Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996;183(4):1797\u2013806.","journal-title":"J Exp Med"},{"issue":"12","key":"10_CR25","first-page":"3860","volume":"118","author":"J Kalabis","year":"2008","unstructured":"Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, et al. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest. 2008;118(12):3860\u20139.","journal-title":"J Clin Invest"},{"issue":"2","key":"10_CR26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1634\/stemcells.2006-0421","volume":"25","author":"D Croagh","year":"2007","unstructured":"Croagh D, Phillips WA, Redvers R, Thomas RJ, Kaur P. Identification of candidate murine esophageal stem cells using a combination of cell kinetic studies and cell surface markers. Stem Cells. 2007;25(2):313\u20138.","journal-title":"Stem Cells"},{"issue":"2","key":"10_CR27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.celrep.2014.09.027","volume":"9","author":"AD DeWard","year":"2014","unstructured":"DeWard AD, Cramer J, Lagasse E. Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population. Cell Rep. 2014;9(2):701\u201311.","journal-title":"Cell Rep"},{"issue":"2","key":"10_CR28","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/MOT.0000000000000174","volume":"20","author":"MH Little","year":"2015","unstructured":"Little MH, Takasato M. Generating a self-organizing kidney from pluripotent cells. Curr Opin Organ Transplant. 2015;20(2):178\u201386.","journal-title":"Curr Opin Organ Transplant"},{"issue":"6098","key":"10_CR29","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.1218835","volume":"337","author":"DP Doupe","year":"2012","unstructured":"Doupe DP, Alcolea MP, Roshan A, Zhang G, Klein AM, Simons BD, Jones PH. A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science. 2012;337(6098):1091\u20133.","journal-title":"Science"},{"issue":"5","key":"10_CR30","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1053\/j.gastro.2004.03.020","volume":"126","author":"H Ireland","year":"2004","unstructured":"Ireland H, Kemp R, Houghton C, Howard L, Clarke AR, Sansom OJ, Winton DJ. Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology. 2004;126(5):1236\u201346.","journal-title":"Gastroenterology"},{"issue":"22","key":"10_CR31","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0960-9822(00)00803-4","volume":"10","author":"JP Seery","year":"2000","unstructured":"Seery JP, Watt FM. Asymmetric stem-cell divisions define the architecture of human oesophageal epithelium. Curr Biol. 2000;10(22):1447\u201350.","journal-title":"Curr Biol"},{"issue":"1","key":"10_CR32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/gutjnl-2013-306171","volume":"64","author":"M Barbera","year":"2015","unstructured":"Barbera M, di Pietro M, Walker E, Brierley C, MacRae S, Simons BD, Jones PH, Stingl J, Fitzgerald RC. The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation. Gut. 2015;64(1):11\u20139.","journal-title":"Gut"},{"issue":"4","key":"10_CR33","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1053\/j.gastro.2012.12.022","volume":"144","author":"Q Pan","year":"2013","unstructured":"Pan Q, Nicholson AM, Barr H, Harrison LA, Wilson GD, Burkert J, Jeffery R, Alison MR, Looijenga L, Lin WR, et al. Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus. Gastroenterology. 2013;144(4):761\u201370.","journal-title":"Gastroenterology"},{"issue":"1","key":"10_CR34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2559.2012.04180.x","volume":"61","author":"E Lorinc","year":"2012","unstructured":"Lorinc E, Oberg S. Submucosal glands in the columnar-lined oesophagus: evidence of an association with metaplasia and neosquamous epithelium. Histopathology. 2012;61(1):53\u20138.","journal-title":"Histopathology"},{"issue":"10","key":"10_CR35","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1111\/j.1572-0241.1999.1422_b.x","volume":"94","author":"JD Long","year":"1999","unstructured":"Long JD, Orlando RC. Esophageal submucosal glands: structure and function. Am J Gastroenterol. 1999;94(10):2818\u201324.","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10_CR36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/path.1804","volume":"206","author":"RA Coad","year":"2005","unstructured":"Coad RA, Woodman AC, Warner PJ, Barr H, Wright NA, Shepherd NA. On the histogenesis of Barrett\u2019s oesophagus and its associated squamous islands: a three-dimensional study of their morphological relationship with native oesophageal gland ducts. J Pathol. 2005;206(4):388\u201394.","journal-title":"J Pathol"},{"issue":"8","key":"10_CR37","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/gut.2007.143339","volume":"57","author":"SJ Leedham","year":"2008","unstructured":"Leedham SJ, Preston SL, McDonald SA, Elia G, Bhandari P, Poller D, Harrison R, Novelli MR, Jankowski JA, Wright NA. Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett\u2019s oesophagus. Gut. 2008;57(8):1041\u20138.","journal-title":"Gut"},{"issue":"2","key":"10_CR38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/bjs.1800750208","volume":"75","author":"P Gillen","year":"1988","unstructured":"Gillen P, Keeling P, Byrne PJ, West AB, Hennessy TP. Experimental columnar metaplasia in the canine oesophagus. Br J Surg. 1988;75(2):113\u20135.","journal-title":"Br J Surg"},{"issue":"2","key":"10_CR39","first-page":"176","volume":"115","author":"H Li","year":"1994","unstructured":"Li H, Walsh TN, O\u2019Dowd G, Gillen P, Byrne PJ, Hennessy TP. Mechanisms of columnar metaplasia and squamous regeneration in experimental Barrett\u2019s esophagus. Surgery. 1994;115(2):176\u201381.","journal-title":"Surgery"},{"issue":"4","key":"10_CR40","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.celrep.2014.03.074","volume":"7","author":"L Mari","year":"2014","unstructured":"Mari L, Milano F, Parikh K, Straub D, Everts V, Hoeben KK, Fockens P, Buttar NS, Krishnadath KK. A pSMAD\/CDX2 complex is essential for the intestinalization of epithelial metaplasia. Cell Rep. 2014;7(4):1197\u2013210.","journal-title":"Cell Rep"},{"key":"10_CR41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1749-6632.2011.06071.x","volume":"1232","author":"M Rishniw","year":"2011","unstructured":"Rishniw M, Rodriguez P, Que J, Burke ZD, Tosh D, Chen H, Chen X. Molecular aspects of esophageal development. Ann N Y Acad Sci. 2011;1232:309\u201315.","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10_CR42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1442-2050.2007.00744.x","volume":"21","author":"G Sarosi","year":"2008","unstructured":"Sarosi G, Brown G, Jaiswal K, Feagins LA, Lee E, Crook TW, Souza RF, Zou YS, Shay JW, Spechler SJ. Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett\u2019s esophagus. Dis Esophagus. 2008;21(1):43\u201350.","journal-title":"Dis Esophagus"},{"issue":"1","key":"10_CR43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/scd.2010.0139","volume":"20","author":"L Hutchinson","year":"2011","unstructured":"Hutchinson L, Stenstrom B, Chen D, Piperdi B, Levey S, Lyle S, Wang TC, Houghton J. Human Barrett\u2019s adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. Stem Cells Dev. 2011;20(1):11\u20137.","journal-title":"Stem Cells Dev"},{"issue":"1","key":"10_CR44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","volume":"21","author":"P Soriano","year":"1999","unstructured":"Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet. 1999;21(1):70\u20131.","journal-title":"Nat Genet"},{"issue":"1","key":"10_CR45","first-page":"209","volume":"68","author":"CG Bremner","year":"1970","unstructured":"Bremner CG, Lynch VP, Ellis Jr FH. Barrett\u2019s esophagus: congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog. Surgery. 1970;68(1):209\u201316.","journal-title":"Surgery"},{"issue":"2","key":"10_CR46","first-page":"53","volume":"20","author":"WM Pollara","year":"1983","unstructured":"Pollara WM, Cecconello I, Zilberstein B, Iria K, Pinotti HW. Regeneration of esophageal epithelium in the presence of gastroesophageal reflux. Arq Gastroenterol. 1983;20(2):53\u20139.","journal-title":"Arq Gastroenterol"},{"issue":"7","key":"10_CR47","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.cell.2011.05.026","volume":"145","author":"X Wang","year":"2011","unstructured":"Wang X, Ouyang H, Yamamoto Y, Kumar PA, Wei TS, Dagher R, Vincent M, Lu X, Bellizzi AM, Ho KY, et al. Residual embryonic cells as precursors of a Barrett\u2019s-like metaplasia. Cell. 2011;145(7):1023\u201335.","journal-title":"Cell"},{"key":"10_CR48","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0016-5085(19)35323-5","volume":"39","author":"MC Goldman","year":"1960","unstructured":"Goldman MC, Beckman RC. Barrett syndrome. Case report with discussion about concepts of pathogenesis. Gastroenterology. 1960;39:104\u201310.","journal-title":"Gastroenterology"},{"issue":"3","key":"10_CR49","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0046-8177(99)90007-2","volume":"30","author":"AH Ormsby","year":"1999","unstructured":"Ormsby AH, Goldblum JR, Rice TW, Richter JE, Falk GW, Vaezi MF, Gramlich TL. Cytokeratin subsets can reliably distinguish Barrett\u2019s esophagus from intestinal metaplasia of the stomach. Hum Pathol. 1999;30(3):288\u201394.","journal-title":"Hum Pathol"},{"issue":"7","key":"10_CR50","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1053\/j.gastro.2012.04.028","volume":"142","author":"W Xian","year":"2012","unstructured":"Xian W, Ho KY, Crum CP, McKeon F. Cellular origin of Barrett\u2019s esophagus: controversy and therapeutic implications. Gastroenterology. 2012;142(7):1424\u201330.","journal-title":"Gastroenterology"},{"issue":"10","key":"10_CR51","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/sj.onc.1200937","volume":"14","author":"H Nakagawa","year":"1997","unstructured":"Nakagawa H, Wang TC, Zukerberg L, Odze R, Togawa K, May GH, Wilson J, Rustgi AK. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene. 1997;14(10):1185\u201390.","journal-title":"Oncogene"},{"issue":"1","key":"10_CR52","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ccr.2011.12.004","volume":"21","author":"M Quante","year":"2012","unstructured":"Quante M, Bhagat G, Abrams JA, Marache F, Good P, Lee MD, Lee Y, Friedman R, Asfaha S, Dubeykovskaya Z, et al. Bile Acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia. Cancer Cell. 2012;21(1):36\u201351.","journal-title":"Cancer Cell"},{"issue":"2","key":"10_CR53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1442-2050.2009.00979.x","volume":"23","author":"L Becker","year":"2010","unstructured":"Becker L, Huang Q, Mashimo H. Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett\u2019s esophagus and esophageal adenocarcinoma. Dis Esophagus. 2010;23(2):168\u201374.","journal-title":"Dis Esophagus"},{"issue":"4","key":"10_CR54","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1440-1746.2011.06928.x","volume":"27","author":"KJ Vega","year":"2012","unstructured":"Vega KJ, May R, Sureban SM, Lightfoot SA, Qu D, Reed A, Weygant N, Ramanujam R, Souza R, Madhoun M, et al. Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett\u2019s esophagus and esophageal adenocarcinoma. J Gastroenterol Hepatol. 2012;27(4):773\u201380.","journal-title":"J Gastroenterol Hepatol"},{"issue":"7","key":"10_CR55","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/PAS.0b013e31819f57e9","volume":"33","author":"HP Hahn","year":"2009","unstructured":"Hahn HP, Blount PL, Ayub K, Das KM, Souza R, Spechler S, Odze RD. Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus. Am J Surg Pathol. 2009;33(7):1006\u201315.","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10_CR56","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1442-2050.2002.00264.x","volume":"15","author":"P Chaves","year":"2002","unstructured":"Chaves P, Pereira AD, Cruz C, Suspiro A, Mendes de Almeida JC, Leitao CN, Soares J. Recurrent columnar-lined esophageal segments\u2014study of the phenotypic characteristics using intestinal markers. Dis Esophagus. 2002;15(4):282\u20136.","journal-title":"Dis Esophagus"},{"issue":"3","key":"10_CR57","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1365-2036.2012.05170.x","volume":"36","author":"A Dias Pereira","year":"2012","unstructured":"Dias Pereira A, Chaves P. Columnar-lined oesophagus without intestinal metaplasia: results from a cohort with a mean follow-up of 7 years. Aliment Pharmacol Ther. 2012;36(3):282\u20139.","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"10_CR58","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/labinvest.2012.47","volume":"92","author":"KT Nam","year":"2012","unstructured":"Nam KT, O\u2019Neal R, Lee YS, Lee YC, Coffey RJ, Goldenring JR. Gastric tumor development in Smad3-deficient mice initiates from forestomach\/glandular transition zone along the lesser curvature. Lab Invest. 2012;92(6):883\u201395.","journal-title":"Lab Invest"},{"issue":"6","key":"10_CR59","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/0016-5085(78)90711-4","volume":"74","author":"DS Schreiber","year":"1978","unstructured":"Schreiber DS, Apstein M, Hermos JA. Paneth cells in Barrett\u2019s esophagus. Gastroenterology. 1978;74(6):1302\u20134.","journal-title":"Gastroenterology"},{"issue":"1","key":"10_CR60","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2559.1987.tb02608.x","volume":"11","author":"M Griffin","year":"1987","unstructured":"Griffin M, Sweeney EC. The relationship of endocrine cells, dysplasia and carcinoembryonic antigen in Barrett\u2019s mucosa to adenocarcinoma of the oesophagus. Histopathology. 1987;11(1):53\u201362.","journal-title":"Histopathology"},{"issue":"3","key":"10_CR61","first-page":"418","volume":"60","author":"DS Levine","year":"1989","unstructured":"Levine DS, Rubin CE, Reid BJ, Haggitt RC. Specialized metaplastic columnar epithelium in Barrett\u2019s esophagus. A comparative transmission electron microscopic study. Lab Invest. 1989;60(3):418\u201332.","journal-title":"Lab Invest"},{"issue":"3","key":"10_CR62","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.surg.2004.01.009","volume":"136","author":"RV Lord","year":"2004","unstructured":"Lord RV, Wickramasinghe K, Johansson JJ, Demeester SR, Brabender J, Demeester TR. Cardiac mucosa in the remnant esophagus after esophagectomy is an acquired epithelium with Barrett\u2019s-like features. Surgery. 2004;136(3):633\u201340.","journal-title":"Surgery"},{"issue":"3","key":"10_CR63","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00000658-200203000-00005","volume":"235","author":"S Oberg","year":"2002","unstructured":"Oberg S, Johansson J, Wenner J, Walther B. Metaplastic columnar mucosa in the cervical esophagus after esophagectomy. Ann Surg. 2002;235(3):338\u201345.","journal-title":"Ann Surg"},{"issue":"6","key":"10_CR64","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/0016-5085(93)90646-T","volume":"104","author":"MM Berenson","year":"1993","unstructured":"Berenson MM, Johnson TD, Markowitz NR, Buchi KN, Samowitz WS. Restoration of squamous mucosa after ablation of Barrett\u2019s esophageal epithelium. Gastroenterology. 1993;104(6):1686\u201391.","journal-title":"Gastroenterology"},{"issue":"3","key":"10_CR65","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0016-5107(95)70356-X","volume":"41","author":"LJ Brandt","year":"1995","unstructured":"Brandt LJ, Blansky RL, Kauvar DR. Repeat laser therapy of recurrent Barrett\u2019s epithelium: success with anacidity. Gastrointest Endosc. 1995;41(3):267.","journal-title":"Gastrointest Endosc"},{"issue":"10","key":"10_CR66","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1136\/gutjnl-2011-301174","volume":"61","author":"AM Nicholson","year":"2012","unstructured":"Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R, Wright NA, McDonald SA, et al. Barrett\u2019s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor. Gut. 2012;61(10):1380\u20139.","journal-title":"Gut"},{"issue":"4","key":"10_CR67","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1172\/JCI71545","volume":"124","author":"H Watanabe","year":"2014","unstructured":"Watanabe H, Ma Q, Peng S, Adelmant G, Swain D, Song W, Fox C, Francis JM, Pedamallu CS, DeLuca DS, et al. SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas. J Clin Invest. 2014;124(4):1636\u201345.","journal-title":"J Clin Invest"},{"issue":"5","key":"10_CR68","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/gut.2008.152975","volume":"58","author":"H Kazumori","year":"2009","unstructured":"Kazumori H, Ishihara S, Kinoshita Y. Roles of caudal-related homeobox gene Cdx1 in oesophageal epithelial cells in Barrett\u2019s epithelium development. Gut. 2009;58(5):620\u20138.","journal-title":"Gut"},{"issue":"1","key":"10_CR69","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1083\/jcb.200311021","volume":"166","author":"P Blache","year":"2004","unstructured":"Blache P, van de Wetering M, Duluc I, Domon C, Berta P, Freund JN, Clevers H, Jay P. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol. 2004;166(1):37\u201347.","journal-title":"J Cell Biol"},{"issue":"15","key":"10_CR70","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.cub.2005.06.064","volume":"15","author":"VP Vidal","year":"2005","unstructured":"Vidal VP, Chaboissier MC, Lutzkendorf S, Cotsarelis G, Mill P, Hui CC, Ortonne N, Ortonne JP, Schedl A. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol. 2005;15(15):1340\u201351.","journal-title":"Curr Biol"},{"issue":"10","key":"10_CR71","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1359\/JBMR.040706","volume":"19","author":"S Tavella","year":"2004","unstructured":"Tavella S, Biticchi R, Schito A, Minina E, Di Martino D, Pagano A, Vortkamp A, Horton WA, Cancedda R, Garofalo S. Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression. J Bone Miner Res. 2004;19(10):1678\u201388.","journal-title":"J Bone Miner Res"},{"issue":"10","key":"10_CR72","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/hmg\/ddm061","volume":"16","author":"GA Bien-Willner","year":"2007","unstructured":"Bien-Willner GA, Stankiewicz P, Lupski JR. SOX9cre1, a cis-acting regulatory element located 1.1 Mb upstream of SOX9, mediates its enhancement through the SHH pathway. Hum Mol Genet. 2007;16(10):1143\u201356.","journal-title":"Hum Mol Genet"},{"issue":"12","key":"10_CR73","doi-asserted-by":"crossref","first-page":"G1335","DOI":"10.1152\/ajpgi.00291.2012","volume":"303","author":"NJ Clemons","year":"2012","unstructured":"Clemons NJ, Wang DH, Croagh D, Tikoo A, Fennell CM, Murone C, Scott AM, Watkins DN, Phillips WA. Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett\u2019s esophagus. Am J Physiol Gastrointest Liver Physiol. 2012;303(12):G1335\u201346.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"13","key":"10_CR74","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.003855","volume":"134","author":"J Que","year":"2007","unstructured":"Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007;134(13):2521\u201331.","journal-title":"Development"},{"issue":"6","key":"10_CR75","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/jmcb\/mjs030","volume":"4","author":"L Raghoebir","year":"2012","unstructured":"Raghoebir L, Bakker ER, Mills JC, Swagemakers S, Kempen MB, Munck AB, Driegen S, Meijer D, Grosveld F, Tibboel D, et al. SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype. J Mol Cell Biol. 2012;4(6):377\u201385.","journal-title":"J Mol Cell Biol"},{"issue":"12","key":"10_CR76","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.humpath.2009.06.006","volume":"40","author":"KB Long","year":"2009","unstructured":"Long KB, Hornick JL. SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract. Hum Pathol. 2009;40(12):1768\u201373.","journal-title":"Hum Pathol"},{"issue":"11","key":"10_CR77","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.465","volume":"41","author":"AJ Bass","year":"2009","unstructured":"Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009;41(11):1238\u201342.","journal-title":"Nat Genet"},{"issue":"4","key":"10_CR78","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.stem.2011.09.001","volume":"9","author":"K Arnold","year":"2011","unstructured":"Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011;9(4):317\u201329.","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10_CR79","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.stem.2013.01.007","volume":"12","author":"K Liu","year":"2013","unstructured":"Liu K, Jiang M, Lu Y, Chen H, Sun J, Wu S, Ku WY, Nakagawa H, Kita Y, Natsugoe S, et al. Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. Cell Stem Cell. 2013;12(3):304\u201315.","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10_CR80","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.yexcr.2005.11.028","volume":"312","author":"CE Barbieri","year":"2006","unstructured":"Barbieri CE, Pietenpol JA. p63 and epithelial biology. Exp Cell Res. 2006;312(6):695\u2013706.","journal-title":"Exp Cell Res"},{"issue":"1","key":"10_CR81","doi-asserted-by":"crossref","first-page":"C171","DOI":"10.1152\/ajpcell.00226.2003","volume":"287","author":"Y Daniely","year":"2004","unstructured":"Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, Oren M, Jetten AM. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol. 2004;287(1):C171\u201381.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"10_CR82","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/gut.49.5.618","volume":"49","author":"PA Hall","year":"2001","unstructured":"Hall PA, Woodman AC, Campbell SJ, Shepherd NA. Expression of the p53 homologue p63alpha and DeltaNp63alpha in the neoplastic sequence of Barrett\u2019s oesophagus: correlation with morphology and p53 protein. Gut. 2001;49(5):618\u201323.","journal-title":"Gut"},{"issue":"11","key":"10_CR83","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1053\/hupa.2001.28951","volume":"32","author":"JN Glickman","year":"2001","unstructured":"Glickman JN, Yang A, Shahsafaei A, McKeon F, Odze RD. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol. 2001;32(11):1157\u201365.","journal-title":"Hum Pathol"},{"issue":"9","key":"10_CR84","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/S0046-8177(03)00342-3","volume":"34","author":"H Geddert","year":"2003","unstructured":"Geddert H, Kiel S, Heep HJ, Gabbert HE, Sarbia M. The role of p63 and deltaNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis. Hum Pathol. 2003;34(9):850\u20136.","journal-title":"Hum Pathol"},{"issue":"1","key":"10_CR85","doi-asserted-by":"crossref","first-page":"G45","DOI":"10.1152\/ajpgi.00583.2006","volume":"293","author":"S Roman","year":"2007","unstructured":"Roman S, Petre A, Thepot A, Hautefeuille A, Scoazec JY, Mion F, Hainaut P. Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture. Am J Physiol Gastrointest Liver Physiol. 2007;293(1):G45\u201353.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"7","key":"10_CR86","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4161\/cbt.3.7.913","volume":"3","author":"RJ Guo","year":"2004","unstructured":"Guo RJ, Suh ER, Lynch JP. The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther. 2004;3(7):593\u2013601.","journal-title":"Cancer Biol Ther"},{"issue":"4","key":"10_CR87","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1053\/gast.2000.18142","volume":"119","author":"DG Silberg","year":"2000","unstructured":"Silberg DG, Swain GP, Suh ER, Traber PG. Cdx1 and cdx2 expression during intestinal development. Gastroenterology. 2000;119(4):961\u201371.","journal-title":"Gastroenterology"},{"issue":"4","key":"10_CR88","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(95)90104-3","volume":"83","author":"V Subramanian","year":"1995","unstructured":"Subramanian V, Meyer BI, Gruss P. Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 1995;83(4):641\u201353.","journal-title":"Cell"},{"issue":"10","key":"10_CR89","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1136\/gut.2003.032482","volume":"53","author":"H Mutoh","year":"2004","unstructured":"Mutoh H, Sakurai S, Satoh K, Osawa H, Hakamata Y, Takeuchi T, Sugano K. Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. Gut. 2004;53(10):1416\u201323.","journal-title":"Gut"},{"issue":"21","key":"10_CR90","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.1073\/pnas.0502031102","volume":"102","author":"NA Wong","year":"2005","unstructured":"Wong NA, Wilding J, Bartlett S, Liu Y, Warren BF, Piris J, Maynard N, Marshall R, Bodmer WF. CDX1 is an important molecular mediator of Barrett\u2019s metaplasia. Proc Natl Acad Sci U S A. 2005;102(21):7565\u201370.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10_CR91","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/modpathol.3800182","volume":"17","author":"GM Groisman","year":"2004","unstructured":"Groisman GM, Amar M, Meir A. Expression of the intestinal marker Cdx2 in the columnar-lined esophagus with and without intestinal (Barrett\u2019s) metaplasia. Mod Pathol. 2004;17(10):1282\u20138.","journal-title":"Mod Pathol"},{"issue":"11","key":"10_CR92","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1097\/00000478-200311000-00006","volume":"27","author":"RW Phillips","year":"2003","unstructured":"Phillips RW, Frierson Jr HF, Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol. 2003;27(11):1442\u20137.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10_CR93","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s005350300001","volume":"38","author":"A Eda","year":"2003","unstructured":"Eda A, Osawa H, Satoh K, Yanaka I, Kihira K, Ishino Y, Mutoh H, Sugano K. Aberrant expression of CDX2 in Barrett\u2019s epithelium and inflammatory esophageal mucosa. J Gastroenterol. 2003;38(1):14\u201322.","journal-title":"J Gastroenterol"},{"issue":"10","key":"10_CR94","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1136\/jcp.2003.015727","volume":"57","author":"LM Moons","year":"2004","unstructured":"Moons LM, Bax DA, Kuipers EJ, Van Dekken H, Haringsma J, Van Vliet AH, Siersema PD, Kusters JG. The homeodomain protein CDX2 is an early marker of Barrett\u2019s oesophagus. J Clin Pathol. 2004;57(10):1063\u20138.","journal-title":"J Clin Pathol"},{"issue":"3","key":"10_CR95","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/aja.1002040302","volume":"204","author":"F Beck","year":"1995","unstructured":"Beck F, Erler T, Russell A, James R. Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev Dyn. 1995;204(3):219\u201327.","journal-title":"Dev Dyn"},{"issue":"6620","key":"10_CR96","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/386084a0","volume":"386","author":"K Chawengsaksophak","year":"1997","unstructured":"Chawengsaksophak K, James R, Hammond VE, Kontgen F, Beck F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature. 1997;386(6620):84\u20137.","journal-title":"Nature"},{"issue":"4","key":"10_CR97","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.devcel.2009.02.010","volume":"16","author":"N Gao","year":"2009","unstructured":"Gao N, White P, Kaestner KH. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell. 2009;16(4):588\u201399.","journal-title":"Dev Cell"},{"issue":"3","key":"10_CR98","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1523-5378.2002.00080.x","volume":"7","author":"K Satoh","year":"2002","unstructured":"Satoh K, Mutoh H, Eda A, Yanaka I, Osawa H, Honda S, Kawata H, Kihira K, Sugano K. Aberrant expression of CDX2 in the gastric mucosa with and without intestinal metaplasia: effect of eradication of Helicobacter pylori. Helicobacter. 2002;7(3):192\u20138.","journal-title":"Helicobacter"},{"issue":"Pt 8","key":"10_CR99","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1242\/jcs.00338","volume":"116","author":"M Marchetti","year":"2003","unstructured":"Marchetti M, Caliot E, Pringault E. Chronic acid exposure leads to activation of the cdx2 intestinal homeobox gene in a long-term culture of mouse esophageal keratinocytes. J Cell Sci. 2003;116(Pt 8):1429\u201336.","journal-title":"J Cell Sci"},{"issue":"35","key":"10_CR100","doi-asserted-by":"crossref","first-page":"31909","DOI":"10.1074\/jbc.M204622200","volume":"277","author":"F Boudreau","year":"2002","unstructured":"Boudreau F, Rings EH, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG. Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem. 2002;277(35):31909\u201317.","journal-title":"J Biol Chem"},{"issue":"6","key":"10_CR101","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/ijc.22828","volume":"121","author":"M Guo","year":"2007","unstructured":"Guo M, House MG, Suzuki H, Ye Y, Brock MV, Lu F, Liu Z, Rustgi AK, Herman JG. Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. Int J Cancer. 2007;121(6):1219\u201326.","journal-title":"Int J Cancer"},{"issue":"2","key":"10_CR102","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1053\/gast.2001.26261","volume":"121","author":"GR Brink van den","year":"2001","unstructured":"van den Brink GR, Hardwick JC, Tytgat GN, Brink MA, Ten Kate FJ, Van Deventer SJ, Peppelenbosch MP. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology. 2001;121(2):317\u201328.","journal-title":"Gastroenterology"},{"issue":"7","key":"10_CR103","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/dev.124.7.1313","volume":"124","author":"H Sasaki","year":"1997","unstructured":"Sasaki H, Hui C, Nakafuku M, Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development. 1997;124(7):1313\u201322.","journal-title":"Development"},{"issue":"2","key":"10_CR104","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.modgep.2004.08.006","volume":"5","author":"V Besnard","year":"2004","unstructured":"Besnard V, Wert SE, Hull WM, Whitsett JA. Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr Patterns. 2004;5(2):193\u2013208.","journal-title":"Gene Expr Patterns"},{"issue":"3","key":"10_CR105","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1442-2050.2007.00683.x","volume":"20","author":"KR Jaiswal","year":"2007","unstructured":"Jaiswal KR, Morales CP, Feagins LA, Gandia KG, Zhang X, Zhang HY, Hormi-Carver K, Shen Y, Elder F, Ramirez RD, et al. Characterization of telomerase-immortalized, non-neoplastic, human Barrett\u2019s cell line (BAR-T). Dis Esophagus. 2007;20(3):256\u201364.","journal-title":"Dis Esophagus"},{"issue":"4","key":"10_CR106","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/sj.onc.1205076","volume":"21","author":"CB Harley","year":"2002","unstructured":"Harley CB. Telomerase is not an oncogene. Oncogene. 2002;21(4):494\u2013502.","journal-title":"Oncogene"},{"issue":"3","key":"10_CR107","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/gut.52.3.327","volume":"52","author":"CP Morales","year":"2003","unstructured":"Morales CP, Gandia KG, Ramirez RD, Wright WE, Shay JW, Spechler SJ. Characterisation of telomerase immortalised normal human oesophageal squamous cells. Gut. 2003;52(3):327\u201333.","journal-title":"Gut"},{"issue":"3","key":"10_CR108","doi-asserted-by":"crossref","first-page":"G470","DOI":"10.1152\/ajpgi.90262.2008","volume":"295","author":"HY Zhang","year":"2008","unstructured":"Zhang HY, Zhang X, Chen X, Thomas D, Hormi-Carver K, Elder F, Spechler SJ, Souza RF. Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett\u2019s esophagus. Am J Physiol Gastrointest Liver Physiol. 2008;295(3):G470\u20138.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"25","key":"10_CR109","doi-asserted-by":"crossref","first-page":"10500","DOI":"10.1073\/pnas.0704054104","volume":"104","author":"FC Lynn","year":"2007","unstructured":"Lynn FC, Smith SB, Wilson ME, Yang KY, Nekrep N, German MS. Sox9 coordinates a transcriptional network in pancreatic progenitor cells. Proc Natl Acad Sci U S A. 2007;104(25):10500\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10_CR110","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bbrc.2008.02.158","volume":"369","author":"M Sluis van der","year":"2008","unstructured":"van der Sluis M, Vincent A, Bouma J, Korteland-Van Male A, van Goudoever JB, Renes IB, Van Seuningen I. Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells. Biochem Biophys Res Commun. 2008;369(4):1108\u201313.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10_CR111","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1053\/j.gastro.2009.08.059","volume":"137","author":"DZ Ye","year":"2009","unstructured":"Ye DZ, Kaestner KH. Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice. Gastroenterology. 2009;137(6):2052\u201362.","journal-title":"Gastroenterology"},{"issue":"17","key":"10_CR112","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.1073\/pnas.0808722106","volume":"106","author":"SW Park","year":"2009","unstructured":"Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N, Erle DJ. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009;106(17):6950\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10_CR113","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ydbio.2009.12.008","volume":"338","author":"F Zhao","year":"2010","unstructured":"Zhao F, Edwards R, Dizon D, Afrasiabi K, Mastroianni JR, Geyfman M, Ouellette AJ, Andersen B, Lipkin SM. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2\u2212\/\u2212 mice. Dev Biol. 2010;338(2):270\u20139.","journal-title":"Dev Biol"},{"issue":"1\u20132","key":"10_CR114","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1242\/dmm.003012","volume":"3","author":"V Menke","year":"2010","unstructured":"Menke V, van Es JH, de Lau W, van den Born M, Kuipers EJ, Siersema PD, de Bruin RW, Kusters JG, Clevers H. Conversion of metaplastic Barrett\u2019s epithelium into post-mitotic goblet cells by gamma-secretase inhibition. Dis Model Mech. 2010;3(1\u20132):104\u201310.","journal-title":"Dis Model Mech"},{"issue":"6","key":"10_CR115","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/labinvest.2012.56","volume":"92","author":"Y Tamagawa","year":"2012","unstructured":"Tamagawa Y, Ishimura N, Uno G, Yuki T, Kazumori H, Ishihara S, Amano Y, Kinoshita Y. Notch signaling pathway and Cdx2 expression in the development of Barrett\u2019s esophagus. Lab Invest. 2012;92(6):896\u2013909.","journal-title":"Lab Invest"}],"container-title":["Advances in Experimental Medicine and Biology","Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-41388-4_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T05:45:25Z","timestamp":1657172725000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-41388-4_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9783319413860","9783319413884"],"references-count":115,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-41388-4_10","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}