{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:51:41Z","timestamp":1785520301386,"version":"3.56.0"},"publisher-location":"Cham","reference-count":92,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319501727","type":"print"},{"value":"9783319501741","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-50174-1_12","type":"book-chapter","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T09:44:03Z","timestamp":1489743843000},"page":"163-175","source":"Crossref","is-referenced-by-count":22,"title":["Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease"],"prefix":"10.1007","author":[{"given":"Yu","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,18]]},"reference":[{"key":"12_CR1","series-title":"NSDUH series H-44, HHS publication no.(SMA)","first-page":"12","volume-title":"Results from the 2011 national survey on drug use and health: summary of national findings","author":"S Abuse","year":"2012","unstructured":"Abuse S, Mental Health Services Administration (2012) Results from the 2011 national survey on drug use and health: summary of national findings, NSDUH series H-44, HHS publication no.(SMA). Substance Abuse and Mental Health Services Administration, Rockville, pp. 12\u20134713"},{"issue":"2","key":"12_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jemermed.2006.05.044","volume":"32","author":"J Glauser","year":"2007","unstructured":"Glauser J, Queen JR (2007) An overview of non-cardiac cocaine toxicity. J Emerg Med 32(2):181\u2013186. doi: 10.1016\/j.jemermed.2006.05.044","journal-title":"J Emerg Med"},{"issue":"2","key":"12_CR3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0376-8716(03)00092-9","volume":"71","author":"E Aharonovich","year":"2003","unstructured":"Aharonovich E, Nunes E, Hasin D (2003) Cognitive impairment, retention and abstinence among cocaine abusers in cognitive-behavioral treatment. Drug Alcohol Depend 71(2):207\u2013211","journal-title":"Drug Alcohol Depend"},{"issue":"8","key":"12_CR4","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1553-2712.2004.tb00771.x","volume":"11","author":"E Rivers","year":"2004","unstructured":"Rivers E, Shirazi E, Aurora T, Mullen M, Gunnerson K, Sheridan B, Eichhorn L, Tomlanovich M (2004) Cocaine use in elder patients presenting to an inner-city emergency department. Acad Emerg Med 11(8):874\u2013877","journal-title":"Acad Emerg Med"},{"issue":"2","key":"12_CR5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/mp.2012.31","volume":"18","author":"KD Ersche","year":"2013","unstructured":"Ersche KD, Jones PS, Williams GB, Robbins TW, Bullmore ET (2013) Cocaine dependence: a fast-track for brain ageing? Mol Psychiatry 18(2):134\u2013135. doi: 10.1038\/mp.2012.31","journal-title":"Mol Psychiatry"},{"key":"12_CR6","volume-title":"World Alzheimer Report 2015: the global impact of dementia: an analysis of prevalence, incidence, cost and trends","author":"M Prince","year":"2015","unstructured":"Prince M, Wimo A, Guerchet M, Ali G, Wu Y, Prina M (2015) World Alzheimer Report 2015: the global impact of dementia: an analysis of prevalence, incidence, cost and trends. Alzheimer\u2019s Disease International, London"},{"issue":"10","key":"12_CR7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s004150070095","volume":"247","author":"A Elbaz","year":"2000","unstructured":"Elbaz A, Manubens-Bertran JM, Baldereschi M, Breteler MM, Grigoletto F, Lopez-Pousa S, Dartigues JF, Alperovitch A, Rocca WA, Tzourio C (2000) Parkinson\u2019s disease, smoking, and family history. EUROPARKINSON Study Group. J Neurol 247(10):793\u2013798","journal-title":"J Neurol"},{"issue":"Suppl 7","key":"12_CR8","first-page":"1","volume":"63","author":"P Mehta","year":"2014","unstructured":"Mehta P, Antao V, Kaye W, Sanchez M, Williamson D, Bryan L, Muravov O, Horton K, Division of T, Human Health Sciences AfTS, Disease Registry AG, Centers for Disease C, Prevention (2014) Prevalence of amyotrophic lateral sclerosis - United States, 2010-2011. Morb Mortal Wkly Rep Surveill Summ 63(Suppl 7):1\u201314","journal-title":"Morb Mortal Wkly Rep Surveill Summ"},{"key":"12_CR9","volume-title":"Huntington\u2019s disease: a disorder of families","author":"SE Folstein","year":"1989","unstructured":"Folstein SE (1989) Huntington\u2019s disease: a disorder of families. Johns Hopkins University Press, Baltimore"},{"issue":"9","key":"12_CR10","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.2174\/156802611795371323","volume":"11","author":"S Narayanan","year":"2011","unstructured":"Narayanan S, Mesangeau C, Poupaert JH, McCurdy CR (2011) Sigma receptors and cocaine abuse. Curr Top Med Chem 11(9):1128\u20131150","journal-title":"Curr Top Med Chem"},{"issue":"8","key":"12_CR11","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2174\/0929867322666150114163607","volume":"22","author":"L Guo","year":"2015","unstructured":"Guo L, Zhen X (2015) Sigma-2 receptor ligands: neurobiological effects. Curr Med Chem 22(8):989\u20131003","journal-title":"Curr Med Chem"},{"issue":"1","key":"12_CR12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jphs.2014.12.005","volume":"127","author":"L Nguyen","year":"2015","unstructured":"Nguyen L, Lucke-Wold BP, Mookerjee SA, Cavendish JZ, Robson MJ, Scandinaro AL, Matsumoto RR (2015) Role of sigma-1 receptors in neurodegenerative diseases. J Pharmacol Sci 127(1):17\u201329. doi: 10.1016\/j.jphs.2014.12.005","journal-title":"J Pharmacol Sci"},{"issue":"10","key":"12_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076941","volume":"8","author":"T Mori","year":"2013","unstructured":"Mori T, Hayashi T, Hayashi E, Su TP (2013) Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival. PLoS One 8(10):e76941. doi: 10.1371\/journal.pone.0076941","journal-title":"PLoS One"},{"issue":"12","key":"12_CR14","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1517\/14728222.2014.972939","volume":"18","author":"SY Tsai","year":"2014","unstructured":"Tsai SY, Pokrass MJ, Klauer NR, De Credico NE, Su TP (2014) Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders. Expert Opin Ther Targets 18(12):1461\u20131476. doi: 10.1517\/14728222.2014.972939","journal-title":"Expert Opin Ther Targets"},{"issue":"12","key":"12_CR15","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.tins.2012.09.007","volume":"35","author":"S Kourrich","year":"2012","unstructured":"Kourrich S, Su TP, Fujimoto M, Bonci A (2012) The sigma-1 receptor: roles in neuronal plasticity and disease. Trends Neurosci 35(12):762\u2013771. doi: 10.1016\/j.tins.2012.09.007","journal-title":"Trends Neurosci"},{"issue":"6","key":"12_CR16","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1016\/S0002-9440(10)65511-3","volume":"155","author":"LM Dallasta","year":"1999","unstructured":"Dallasta LM, Pisarov LA, Esplen JE, Werley JV, Moses AV, Nelson JA, Achim CL (1999) Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am J Pathol 155(6):1915\u20131927. doi: 10.1016\/S0002-9440(10)65511-3","journal-title":"Am J Pathol"},{"issue":"8","key":"12_CR17","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1182\/blood-2010-10-313593","volume":"117","author":"H Yao","year":"2011","unstructured":"Yao H, Duan M, Buch S (2011) Cocaine-mediated induction of platelet-derived growth factor: implication for increased vascular permeability. Blood 117(8):2538\u20132547. doi: 10.1182\/blood-2010-10-313593","journal-title":"Blood"},{"issue":"16","key":"12_CR18","doi-asserted-by":"publisher","first-page":"5942","DOI":"10.1523\/JNEUROSCI.5618-10.2011","volume":"31","author":"H Yao","year":"2011","unstructured":"Yao H, Kim K, Duan M, Hayashi T, Guo M, Morgello S, Prat A, Wang J, Su TP, Buch S (2011) Cocaine hijacks sigma1 receptor to initiate induction of activated leukocyte cell adhesion molecule: implication for increased monocyte adhesion and migration in the CNS. J Neurosci 31(16):5942\u20135955. doi: 10.1523\/JNEUROSCI.5618-10.2011","journal-title":"J Neurosci"},{"issue":"23","key":"12_CR19","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1182\/blood-2010-01-266221","volume":"115","author":"H Yao","year":"2010","unstructured":"Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ, Buch S (2010) Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood 115(23):4951\u20134962. doi: 10.1182\/blood-2010-01-266221","journal-title":"Blood"},{"key":"12_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9094-5","author":"L Yang","year":"2015","unstructured":"Yang L, Yao H, Chen X, Cai Y, Callen S, Buch S (2015) Role of sigma receptor in cocaine-mediated induction of glial fibrillary acidic protein: implications for HAND. Mol Neurobiol. doi: 10.1007\/s12035-015-9094-5","journal-title":"Mol Neurobiol"},{"issue":"2","key":"12_CR21","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1080\/13550280902755375","volume":"15","author":"H Yao","year":"2009","unstructured":"Yao H, Allen JE, Zhu X, Callen S, Buch S (2009) Cocaine and human immunodeficiency virus type 1 gp120 mediate neurotoxicity through overlapping signaling pathways. J Neurovirol 15(2):164\u2013175. doi: 10.1080\/13550280902755375","journal-title":"J Neurovirol"},{"issue":"3","key":"12_CR22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/13550280590952835","volume":"11","author":"M Fiala","year":"2005","unstructured":"Fiala M, Eshleman AJ, Cashman J, Lin J, Lossinsky AS, Suarez V, Yang W, Zhang J, Popik W, Singer E, Chiappelli F, Carro E, Weinand M, Witte M, Arthos J (2005) Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells. J Neurovirol 11(3):281\u2013291. doi: 10.1080\/13550280590952835","journal-title":"J Neurovirol"},{"key":"12_CR23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/B978-0-12-420118-7.00009-3","volume":"69","author":"RR Matsumoto","year":"2014","unstructured":"Matsumoto RR, Nguyen L, Kaushal N, Robson MJ (2014) Sigma (sigma) receptors as potential therapeutic targets to mitigate psychostimulant effects. Adv Pharmacol 69:323\u2013386. doi: 10.1016\/B978-0-12-420118-7.00009-3","journal-title":"Adv Pharmacol"},{"issue":"3","key":"12_CR24","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","volume":"131","author":"T Hayashi","year":"2007","unstructured":"Hayashi T, Su TP (2007) Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell 131(3):596\u2013610. doi: 10.1016\/j.cell.2007.08.036","journal-title":"Cell"},{"issue":"4","key":"12_CR25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0149-7634(02)00017-9","volume":"26","author":"T Maurice","year":"2002","unstructured":"Maurice T, Martin-Fardon R, Romieu P, Matsumoto RR (2002) Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity. Neurosci Biobehav Rev 26(4):499\u2013527","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"12_CR26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/1570162X12666140526123119","volume":"12","author":"M Duan","year":"2014","unstructured":"Duan M, Yao H, Cai Y, Liao K, Seth P, Buch S (2014) HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NF-kappaBYY1 pathway. Curr HIV Res 12(3):189\u2013200","journal-title":"Curr HIV Res"},{"issue":"1","key":"12_CR27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/157436212799278070","volume":"7","author":"H Yao","year":"2012","unstructured":"Yao H, Bethel-Brown C, Yang L, Cai Y, Kanmogne M, Mudgapalli V, Fields N, Buch S (2012) Signal transduction in HIV protein-treated astrocytes. Curr Signal Transduction Ther 7(1):28\u201334","journal-title":"Curr Signal Transduction Ther"},{"key":"12_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9536-0","author":"L Yang","year":"2015","unstructured":"Yang L, Chen X, Hu G, Cai Y, Liao K, Buch S (2015) Mechanisms of platelet-derived growth factor-BB in restoring HIV at-cocaine-mediated impairment of neuronal differentiation. Mol Neurobiol. doi: 10.1007\/s12035-015-9536-0","journal-title":"Mol Neurobiol"},{"issue":"1","key":"12_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","volume":"16","author":"P Ballabh","year":"2004","unstructured":"Ballabh P, Braun A, Nedergaard M (2004) The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis 16(1):1\u201313. doi: 10.1016\/j.nbd.2003.12.016","journal-title":"Neurobiol Dis"},{"issue":"1","key":"12_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj20150934","volume":"473","author":"GC Brailoiu","year":"2015","unstructured":"Brailoiu GC, Deliu E, Console-Bram LM, Soboloff J, Abood ME, Unterwald EM, Brailoiu E (2015) Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors. Biochem J 473(1):1\u20135. doi: 10.1042\/bj20150934","journal-title":"Biochem J"},{"issue":"6","key":"12_CR31","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.intimp.2005.12.005","volume":"6","author":"G Gekker","year":"2006","unstructured":"Gekker G, Hu S, Sheng WS, Rock RB, Lokensgard JR, Peterson PK (2006) Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1. Int Immunopharmacol 6(6):1029\u20131033. doi: 10.1016\/j.intimp.2005.12.005","journal-title":"Int Immunopharmacol"},{"issue":"12","key":"12_CR32","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1089\/ars.2007.1782","volume":"9","author":"JD Malhotra","year":"2007","unstructured":"Malhotra JD, Kaufman RJ (2007) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 9(12):2277\u20132293. doi: 10.1089\/ars.2007.1782","journal-title":"Antioxid Redox Signal"},{"issue":"7","key":"12_CR33","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1080\/15548627.2015.1052205","volume":"11","author":"ML Guo","year":"2015","unstructured":"Guo ML, Liao K, Periyasamy P, Yang L, Cai Y, Callen SE, Buch S (2015) Cocaine-mediated microglial activation involves the ER stress-autophagy axis. Autophagy 11(7):995\u20131009. doi: 10.1080\/15548627.2015.1052205","journal-title":"Autophagy"},{"issue":"24","key":"12_CR34","doi-asserted-by":"publisher","first-page":"9220","DOI":"10.1128\/MCB.01453-06","volume":"26","author":"M Ogata","year":"2006","unstructured":"Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, Imaizumi K (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26(24):9220\u20139231. doi: 10.1128\/MCB.01453-06","journal-title":"Mol Cell Biol"},{"issue":"1","key":"12_CR35","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1091\/mbc.E15-07-0514","volume":"27","author":"S Xie","year":"2016","unstructured":"Xie S, Bahl K, Reinecke JB, Hammond GR, Naslavsky N, Caplan S (2016) The endocytic recycling compartment maintains cargo segregation acquired upon exit from the sorting endosome. Mol Biol Cell 27(1):108\u2013126. doi: 10.1091\/mbc.E15-07-0514","journal-title":"Mol Biol Cell"},{"key":"12_CR36","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/bs.mcb.2015.04.002","volume":"130","author":"JB Reineke","year":"2015","unstructured":"Reineke JB, Xie S, Naslavsky N, Caplan S (2015) Qualitative and quantitative analysis of endocytic recycling. Methods Cell Biol 130:139\u2013155. doi: 10.1016\/bs.mcb.2015.04.002","journal-title":"Methods Cell Biol"},{"key":"12_CR37","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fcell.2014.00022","volume":"2","author":"B Cai","year":"2014","unstructured":"Cai B, Xie S, Caplan S, Naslavsky N (2014) GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation. Front Cell Dev Biol 2:22. doi: 10.3389\/fcell.2014.00022","journal-title":"Front Cell Dev Biol"},{"issue":"46","key":"12_CR38","doi-asserted-by":"publisher","first-page":"31914","DOI":"10.1074\/jbc.M114.594291","volume":"289","author":"S Xie","year":"2014","unstructured":"Xie S, Naslavsky N, Caplan S (2014) Diacylglycerol kinase alpha regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling. J Biol Chem 289(46):31914\u201331926. doi: 10.1074\/jbc.M114.594291","journal-title":"J Biol Chem"},{"issue":"17","key":"12_CR39","doi-asserted-by":"publisher","first-page":"12109","DOI":"10.1074\/jbc.M113.547083","volume":"289","author":"B Cai","year":"2014","unstructured":"Cai B, Xie S, Liu F, Simone LC, Caplan S, Qin X, Naslavsky N (2014) Rapid degradation of the complement regulator, CD59, by a novel inhibitor. J Biol Chem 289(17):12109\u201312125. doi: 10.1074\/jbc.M113.547083","journal-title":"J Biol Chem"},{"issue":"2","key":"12_CR40","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/15548627.2015.1121360","volume":"12","author":"Y Cai","year":"2016","unstructured":"Cai Y, Arikkath J, Yang L, Guo M, Periyasamy P, Buch S (2016) Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy 12(2):225\u2013244. doi: 10.1080\/15548627.2015.1121360","journal-title":"Autophagy"},{"issue":"1","key":"12_CR41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/156720511794604543","volume":"8","author":"C Li","year":"2011","unstructured":"Li C, Zhao R, Gao K, Wei Z, Yin MY, Lau LT, Chui D, Hoi Yu AC (2011) Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer\u2019s disease. Curr Alzheimer Res 8(1):67\u201380","journal-title":"Curr Alzheimer Res"},{"key":"12_CR42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neulet.2014.01.014","volume":"565","author":"AM Colangelo","year":"2014","unstructured":"Colangelo AM, Alberghina L, Papa M (2014) Astrogliosis as a therapeutic target for neurodegenerative diseases. Neurosci Lett 565:59\u201364. doi: 10.1016\/j.neulet.2014.01.014","journal-title":"Neurosci Lett"},{"issue":"6","key":"12_CR43","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","volume":"140","author":"CK Glass","year":"2010","unstructured":"Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140(6):918\u2013934. doi: 10.1016\/j.cell.2010.02.016","journal-title":"Cell"},{"issue":"1-2","key":"12_CR44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0165-5728(97)00225-7","volume":"83","author":"K Goodkin","year":"1998","unstructured":"Goodkin K, Shapshak P, Metsch LR, McCoy CB, Crandall KA, Kumar M, Fujimura RK, McCoy V, Zhang BT, Reyblat S, Xin KQ, Kumar AM (1998) Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis. J Neuroimmunol 83(1-2):88\u2013101","journal-title":"J Neuroimmunol"},{"issue":"1","key":"12_CR45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(01)00598-X","volume":"110","author":"L Fattore","year":"2002","unstructured":"Fattore L, Puddu MC, Picciau S, Cappai A, Fratta W, Serra GP, Spiga S (2002) Astroglial in vivo response to cocaine in mouse dentate gyrus: a quantitative and qualitative analysis by confocal microscopy. Neuroscience 110(1):1\u20136","journal-title":"Neuroscience"},{"issue":"20","key":"12_CR46","doi-asserted-by":"crossref","first-page":"9717","DOI":"10.1128\/JVI.74.20.9717-9726.2000","volume":"74","author":"CA Patel","year":"2000","unstructured":"Patel CA, Mukhtar M, Pomerantz RJ (2000) Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells. J Virol 74(20):9717\u20139726","journal-title":"J Virol"},{"issue":"1","key":"12_CR47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3844\/ajidsp.2009.26.30","volume":"5","author":"H Yao","year":"2009","unstructured":"Yao H, Bethel-Brown C, Buch S (2009) Cocaine exposure results in formation of dendritic varicosity in rat primary hippocampal neurons. Am J Infect Dis 5(1):26\u201330","journal-title":"Am J Infect Dis"},{"issue":"2","key":"12_CR48","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","volume":"81","author":"DJ Selkoe","year":"2001","unstructured":"Selkoe DJ (2001) Alzheimer\u2019s disease: genes, proteins, and therapy. Physiol Rev 81(2):741\u2013766","journal-title":"Physiol Rev"},{"issue":"3","key":"12_CR49","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s12149-007-0094-z","volume":"22","author":"M Mishina","year":"2008","unstructured":"Mishina M, Ohyama M, Ishii K, Kitamura S, Kimura Y, Oda K, Kawamura K, Sasaki T, Kobayashi S, Katayama Y, Ishiwata K (2008) Low density of sigma1 receptors in early Alzheimer\u2019s disease. Ann Nucl Med 22(3):151\u2013156. doi: 10.1007\/s12149-007-0094-z","journal-title":"Ann Nucl Med"},{"issue":"2","key":"12_CR50","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0006-8993(93)91441-T","volume":"623","author":"KL Jansen","year":"1993","unstructured":"Jansen KL, Faull RL, Storey P, Leslie RA (1993) Loss of sigma binding sites in the CA1 area of the anterior hippocampus in Alzheimer\u2019s disease correlates with CA1 pyramidal cell loss. Brain Res 623(2):299\u2013302","journal-title":"Brain Res"},{"issue":"2","key":"12_CR51","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.bbr.2009.12.043","volume":"221","author":"A Waarde van","year":"2011","unstructured":"van Waarde A, Ramakrishnan NK, Rybczynska AA, Elsinga PH, Ishiwata K, Nijholt IM, Luiten PG, Dierckx RA (2011) The cholinergic system, sigma-1 receptors and cognition. Behav Brain Res 221(2):543\u2013554. doi: 10.1016\/j.bbr.2009.12.043","journal-title":"Behav Brain Res"},{"issue":"4","key":"12_CR52","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/0891988710383571","volume":"23","author":"LM Bekris","year":"2010","unstructured":"Bekris LM, Yu CE, Bird TD, Tsuang DW (2010) Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol 23(4):213\u2013227. doi: 10.1177\/0891988710383571","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"7","key":"12_CR53","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2174\/156720511797633232","volume":"8","author":"Y Huang","year":"2011","unstructured":"Huang Y, Zheng L, Halliday G, Dobson-Stone C, Wang Y, Tang HD, Cao L, Deng YL, Wang G, Zhang YM, Wang JH, Hallupp M, Kwok J, Chen SD (2011) Genetic polymorphisms in sigma-1 receptor and apolipoprotein E interact to influence the severity of Alzheimer\u2019s disease. Curr Alzheimer Res 8(7):765\u2013770","journal-title":"Curr Alzheimer Res"},{"issue":"2","key":"12_CR54","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neulet.2012.04.046","volume":"517","author":"\u00c1 Feh\u00e9r","year":"2012","unstructured":"Feh\u00e9r \u00c1, Juh\u00e1sz A, L\u00e1szl\u00f3 A, K\u00e1lm\u00e1n J, P\u00e1k\u00e1ski M, K\u00e1lm\u00e1n J, Janka Z (2012) Association between a variant of the sigma-1 receptor gene and Alzheimer\u2019s disease. Neurosci Lett 517(2):136\u2013139. doi: 10.1016\/j.neulet.2012.04.046","journal-title":"Neurosci Lett"},{"issue":"6","key":"12_CR55","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1159\/000101990","volume":"23","author":"A Maruszak","year":"2007","unstructured":"Maruszak A, Safranow K, Gacia M, Gabryelewicz T, Slowik A, Styczynska M, Peplonska B, Golan MP, Zekanowski C, Barcikowska M (2007) Sigma receptor type 1 gene variation in a group of Polish patients with Alzheimer\u2019s disease and mild cognitive impairment. Dement Geriatr Cogn Disord 23(6):432\u2013438. doi: 10.1159\/000101990","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"2","key":"12_CR56","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1124\/jpet.113.208330","volume":"347","author":"AA Behensky","year":"2013","unstructured":"Behensky AA, Yasny IE, Shuster AM, Seredenin SB, Petrov AV, Cuevas J (2013) Afobazole activation of \u22121 receptors modulates neuronal responses to Amyloid- 25-35. J Pharmacol Exp Ther 347(2):468\u2013477. doi: 10.1124\/jpet.113.208330","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"12_CR57","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1124\/jpet.113.208348","volume":"347","author":"AA Behensky","year":"2013","unstructured":"Behensky AA, Yasny IE, Shuster AM, Seredenin SB, Petrov AV, Cuevas J (2013) Stimulation of sigma receptors with afobazole blocks activation of microglia and reduces toxicity caused by Amyloid- 25-35. J Pharmacol Exp Ther 347(2):458\u2013467. doi: 10.1124\/jpet.113.208348","journal-title":"J Pharmacol Exp Ther"},{"issue":"9","key":"12_CR58","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1038\/npp.2013.70","volume":"38","author":"V Lahmy","year":"2013","unstructured":"Lahmy V, Meunier J, Malmstr\u00f6m S, Naert G, Givalois L, Kim SH, Villard V, Vamvakides A, Maurice T (2013) Blockade of Tau Hyperphosphorylation and A\u03b21\u201342 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and \u03c31 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer\u2019s Disease. Neuropsychopharmacology 38(9):1706\u20131723. doi: 10.1038\/npp.2013.70","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"12_CR59","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1177\/0269881110379286","volume":"25","author":"V Villard","year":"2010","unstructured":"Villard V, Espallergues J, Keller E, Vamvakides A, Maurice T (2010) Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor\/sigma1 ( 1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J Psychopharmacol 25(8):1101\u20131117. doi: 10.1177\/0269881110379286","journal-title":"J Psychopharmacol"},{"issue":"19","key":"12_CR60","doi-asserted-by":"publisher","first-page":"7916","DOI":"10.1073\/pnas.1300677110","volume":"110","author":"L Hedskog","year":"2013","unstructured":"Hedskog L, Pinho CM, Filadi R, Ronnback A, Hertwig L, Wiehager B, Larssen P, Gellhaar S, Sandebring A, Westerlund M, Graff C, Winblad B, Galter D, Behbahani H, Pizzo P, Glaser E, Ankarcrona M (2013) Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer\u2019s disease and related models. Proc Natl Acad Sci 110(19):7916\u20137921. doi: 10.1073\/pnas.1300677110","journal-title":"Proc Natl Acad Sci"},{"key":"12_CR61","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.bbr.2015.09.020","volume":"296","author":"T Maurice","year":"2016","unstructured":"Maurice T (2016) Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments. Behav Brain Res 296:270\u2013278. doi: 10.1016\/j.bbr.2015.09.020","journal-title":"Behav Brain Res"},{"issue":"15","key":"12_CR62","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1056\/NEJM199810083391506","volume":"339","author":"AE Lang","year":"1998","unstructured":"Lang AE, Lozano AM (1998) Parkinson\u2019s disease. First of two parts. N Engl J Med 339(15):1044\u20131053. doi: 10.1056\/NEJM199810083391506","journal-title":"N Engl J Med"},{"issue":"16","key":"12_CR63","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1056\/NEJM199810153391607","volume":"339","author":"AE Lang","year":"1998","unstructured":"Lang AE, Lozano AM (1998) Parkinson\u2019s disease. Second of two parts. N Engl J Med 339(16):1130\u20131143. doi: 10.1056\/NEJM199810153391607","journal-title":"N Engl J Med"},{"issue":"2","key":"12_CR64","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1600-0404.2005.00432.x","volume":"112","author":"M Mishina","year":"2005","unstructured":"Mishina M, Ishiwata K, Ishii K, Kitamura S, Kimura Y, Kawamura K, Oda K, Sasaki T, Sakayori O, Hamamoto M, Kobayashi S, Katayama Y (2005) Function of sigma1 receptors in Parkinson\u2019s disease. Acta Neurol Scand 112(2):103\u2013107. doi: 10.1111\/j.1600-0404.2005.00432.x","journal-title":"Acta Neurol Scand"},{"issue":"3","key":"12_CR65","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1124\/jpet.111.190868","volume":"341","author":"T Mori","year":"2012","unstructured":"Mori T, Hayashi T, Su TP (2012) Compromising sigma-1 receptors at the endoplasmic reticulum render cytotoxicity to physiologically relevant concentrations of dopamine in a nuclear factor-kappaB\/Bcl-2-dependent mechanism: potential relevance to Parkinson\u2019s disease. J Pharmacol Exp Ther 341(3):663\u2013671. doi: 10.1124\/jpet.111.190868","journal-title":"J Pharmacol Exp Ther"},{"issue":"Pt 7","key":"12_CR66","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1093\/brain\/awu107","volume":"137","author":"V Francardo","year":"2014","unstructured":"Francardo V, Bez F, Wieloch T, Nissbrandt H, Ruscher K, Cenci MA (2014) Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism. Brain J Neurol 137(Pt 7):1998\u20132014. doi: 10.1093\/brain\/awu107","journal-title":"Brain J Neurol"},{"issue":"4","key":"12_CR67","doi-asserted-by":"publisher","first-page":"606","DOI":"10.3171\/jns.2004.100.4.0606","volume":"100","author":"T Nimura","year":"2004","unstructured":"Nimura T, Ando T, Yamaguchi K, Nakajima T, Shirane R, Itoh M, Tominaga T (2004) The role of sigma-receptors in levodopa-induced dyskinesia in patients with advanced Parkinson disease: a positron emission tomography study. J Neurosurg 100(4):606\u2013610. doi: 10.3171\/jns.2004.100.4.0606","journal-title":"J Neurosurg"},{"issue":"4","key":"12_CR68","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00213-009-1505-8","volume":"204","author":"MA Paquette","year":"2009","unstructured":"Paquette MA, Foley K, Brudney EG, Meshul CK, Johnson SW, Berger SP (2009) The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism. Psychopharmacology 204(4):743\u2013754. doi: 10.1007\/s00213-009-1505-8","journal-title":"Psychopharmacology"},{"issue":"1","key":"12_CR69","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bbr.2008.02.034","volume":"190","author":"A Dijk van","year":"2008","unstructured":"van Dijk A, Johnston C, Allbutt H, Kassiou M, Henderson J (2008) Behavioural effects of trishomocubanes in rats with unilateral 6-hydroxydopamine lesions. Behav Brain Res 190(1):14\u201321. doi: 10.1016\/j.bbr.2008.02.034","journal-title":"Behav Brain Res"},{"issue":"1","key":"12_CR70","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.nurt.2006.11.011","volume":"4","author":"RG Fariello","year":"2007","unstructured":"Fariello RG (2007) Safinamide. Neurotherapeutics 4(1):110\u2013116. doi: 10.1016\/j.nurt.2006.11.011","journal-title":"Neurotherapeutics"},{"issue":"1","key":"12_CR71","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","volume":"52","author":"S Boillee","year":"2006","unstructured":"Boillee S, Vande Velde C, Cleveland DW (2006) ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52(1):39\u201359. doi: 10.1016\/j.neuron.2006.09.018","journal-title":"Neuron"},{"issue":"4","key":"12_CR72","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nrn3430","volume":"14","author":"W Robberecht","year":"2013","unstructured":"Robberecht W, Philips T (2013) The changing scene of amyotrophic lateral sclerosis. Nat Rev Neurosci 14(4):248\u2013264. doi: 10.1038\/nrn3430","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"12_CR73","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2174\/156720511795563700","volume":"8","author":"R Ferrari","year":"2011","unstructured":"Ferrari R, Kapogiannis D, Huey ED, Momeni P (2011) FTD and ALS: a tale of two diseases. Curr Alzheimer Res 8(3):273\u2013294","journal-title":"Curr Alzheimer Res"},{"issue":"8","key":"12_CR74","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1136\/jmg.2010.077180","volume":"47","author":"S Millecamps","year":"2010","unstructured":"Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, Guillot-Noel L, Russaouen O, Bruneteau G, Pradat PF, Le Forestier N, Vandenberghe N, Danel-Brunaud V, Guy N, Thauvin-Robinet C, Lacomblez L, Couratier P, Hannequin D, Seilhean D, Le Ber I, Corcia P, Camu W, Brice A, Rouleau G, LeGuern E, Meininger V (2010) SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations. J Med Genet 47(8):554\u2013560. doi: 10.1136\/jmg.2010.077180","journal-title":"J Med Genet"},{"issue":"2","key":"12_CR75","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1136\/jmg.2008.062463","volume":"46","author":"H Daoud","year":"2009","unstructured":"Daoud H, Valdmanis PN, Kabashi E, Dion P, Dupre N, Camu W, Meininger V, Rouleau GA (2009) Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis. J Med Genet 46(2):112\u2013114. doi: 10.1136\/jmg.2008.062463","journal-title":"J Med Genet"},{"issue":"6","key":"12_CR76","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1523\/JNEUROSCI.06-06-01757.1986","volume":"6","author":"AL Gundlach","year":"1986","unstructured":"Gundlach AL, Largent BL, Snyder SH (1986) Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine. J Neurosci 6(6):1757\u20131770","journal-title":"J Neurosci"},{"issue":"2","key":"12_CR77","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuroscience.2010.02.022","volume":"167","author":"TA Mavlyutov","year":"2010","unstructured":"Mavlyutov TA, Epstein ML, Andersen KA, Ziskind-Conhaim L, Ruoho AE (2010) The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons: an anatomical and behavioral study. Neuroscience 167(2):247\u2013255. doi: 10.1016\/j.neuroscience.2010.02.022","journal-title":"Neuroscience"},{"issue":"6","key":"12_CR78","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/ana.22534","volume":"70","author":"A Al-Saif","year":"2011","unstructured":"Al-Saif A, Al-Mohanna F, Bohlega S (2011) A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann Neurol 70(6):913\u2013919. doi: 10.1002\/ana.22534","journal-title":"Ann Neurol"},{"issue":"5","key":"12_CR79","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/ana.22274","volume":"68","author":"AA Luty","year":"2010","unstructured":"Luty AA, Kwok JB, Dobson-Stone C, Loy CT, Coupland KG, Karlstrom H, Sobow T, Tchorzewska J, Maruszak A, Barcikowska M, Panegyres PK, Zekanowski C, Brooks WS, Williams KL, Blair IP, Mather KA, Sachdev PS, Halliday GM, Schofield PR (2010) Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease. Ann Neurol 68(5):639\u2013649. doi: 10.1002\/ana.22274","journal-title":"Ann Neurol"},{"issue":"8","key":"12_CR80","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1093\/hmg\/ddt008","volume":"22","author":"J Prause","year":"2013","unstructured":"Prause J, Goswami A, Katona I, Roos A, Schnizler M, Bushuven E, Dreier A, Buchkremer S, Johann S, Beyer C, Deschauer M, Troost D, Weis J (2013) Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis. Hum Mol Genet 22(8):1581\u20131600. doi: 10.1093\/hmg\/ddt008","journal-title":"Hum Mol Genet"},{"issue":"2","key":"12_CR81","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/bpa.12355","volume":"26","author":"S Rossi","year":"2016","unstructured":"Rossi S, Cozzolino M, Teresa Carri M (2016) Old versus new mechanisms in the pathogenesis of ALS. Brain Pathol 26(2):276\u2013286. doi: 10.1111\/bpa.12355","journal-title":"Brain Pathol"},{"key":"12_CR82","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.neuroscience.2013.02.035","volume":"240","author":"TA Mavlyutov","year":"2013","unstructured":"Mavlyutov TA, Epstein ML, Verbny YI, Huerta MS, Zaitoun I, Ziskind-Conhaim L, Ruoho AE (2013) Lack of sigma-1 receptor exacerbates ALS progression in mice. Neuroscience 240:129\u2013134. doi: 10.1016\/j.neuroscience.2013.02.035","journal-title":"Neuroscience"},{"issue":"4","key":"12_CR83","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s13311-012-0140-y","volume":"9","author":"R Mancuso","year":"2012","unstructured":"Mancuso R, Olivan S, Rando A, Casas C, Osta R, Navarro X (2012) Sigma-1R agonist improves motor function and motoneuron survival in ALS mice. Neurotherapeutics 9(4):814\u2013826. doi: 10.1007\/s13311-012-0140-y","journal-title":"Neurotherapeutics"},{"key":"12_CR84","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.nbd.2013.10.010","volume":"62","author":"M Peviani","year":"2014","unstructured":"Peviani M, Salvaneschi E, Bontempi L, Petese A, Manzo A, Rossi D, Salmona M, Collina S, Bigini P, Curti D (2014) Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis 62:218\u2013232. doi: 10.1016\/j.nbd.2013.10.010","journal-title":"Neurobiol Dis"},{"issue":"7","key":"12_CR85","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1002\/ajmg.a.32901","volume":"149A","author":"AE Hendricks","year":"2009","unstructured":"Hendricks AE, Latourelle JC, Lunetta KL, Cupples LA, Wheeler V, MacDonald ME, Gusella JF, Myers RH (2009) Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG). Am J Med Genet A 149A(7):1375\u20131381. doi: 10.1002\/ajmg.a.32901","journal-title":"Am J Med Genet A"},{"issue":"21","key":"12_CR86","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1093\/hmg\/ddm217","volume":"16","author":"RS Atwal","year":"2007","unstructured":"Atwal RS, Xia J, Pinchev D, Taylor J, Epand RM, Truant R (2007) Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity. Hum Mol Genet 16(21):2600\u20132615. doi: 10.1093\/hmg\/ddm217","journal-title":"Hum Mol Genet"},{"issue":"1","key":"12_CR87","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4161\/auto.5201","volume":"4","author":"RS Atwal","year":"2008","unstructured":"Atwal RS, Truant R (2008) A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy. Autophagy 4(1):91\u201393","journal-title":"Autophagy"},{"issue":"12","key":"12_CR88","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/hmg\/ddg156","volume":"12","author":"J Xia","year":"2003","unstructured":"Xia J, Lee DH, Taylor J, Vandelft M, Truant R (2003) Huntingtin contains a highly conserved nuclear export signal. Hum Mol Genet 12(12):1393\u20131403","journal-title":"Hum Mol Genet"},{"issue":"2","key":"12_CR89","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/neup.12080","volume":"34","author":"Y Miki","year":"2014","unstructured":"Miki Y, Mori F, Kon T, Tanji K, Toyoshima Y, Yoshida M, Sasaki H, Kakita A, Takahashi H, Wakabayashi K (2014) Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases. Neuropathology 34(2):148\u2013158. doi: 10.1111\/neup.12080","journal-title":"Neuropathology"},{"key":"12_CR90","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.170","volume":"4","author":"A Hyrskyluoto","year":"2013","unstructured":"Hyrskyluoto A, Pulli I, Tornqvist K, Ho TH, Korhonen L, Lindholm D (2013) Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kappaB pathway. Cell Death Dis 4:e646. doi: 10.1038\/cddis.2013.170","journal-title":"Cell Death Dis"},{"issue":"5","key":"12_CR91","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/WNF.0b013e3181ebb285","volume":"33","author":"A Lundin","year":"2010","unstructured":"Lundin A, Dietrichs E, Haghighi S, Goller ML, Heiberg A, Loutfi G, Widner H, Wiktorin K, Wiklund L, Svenningsson A, Sonesson C, Waters N, Waters S, Tedroff J (2010) Efficacy and safety of the dopaminergic stabilizer Pridopidine (ACR16) in patients with Huntington\u2019s disease. Clin Neuropharmacol 33(5):260\u2013264. doi: 10.1097\/WNF.0b013e3181ebb285","journal-title":"Clin Neuropharmacol"},{"issue":"1","key":"12_CR92","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/mp.2012.3","volume":"18","author":"K Sahlholm","year":"2013","unstructured":"Sahlholm K, Arhem P, Fuxe K, Marcellino D (2013) The dopamine stabilizers ACR16 and (\u2212)-OSU6162 display nanomolar affinities at the sigma-1 receptor. Mol Psychiatry 18(1):12\u201314. doi: 10.1038\/mp.2012.3","journal-title":"Mol Psychiatry"}],"container-title":["Advances in Experimental Medicine and Biology","Sigma Receptors: Their Role in Disease and as Therapeutic Targets"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-50174-1_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T18:05:59Z","timestamp":1568916359000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-50174-1_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319501727","9783319501741"],"references-count":92,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-50174-1_12","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}