{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:26:18Z","timestamp":1790767578676,"version":"4.1.0"},"publisher-location":"Cham","reference-count":101,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319514086","type":"print"},{"value":"9783319514093","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-51409-3_3","type":"book-chapter","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T09:44:44Z","timestamp":1491558284000},"page":"45-65","source":"Crossref","is-referenced-by-count":60,"title":["The Role of Heat Shock Factors in Mammalian Spermatogenesis"],"prefix":"10.1007","author":[{"given":"Wieslawa","family":"Widlak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Vydra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,8]]},"reference":[{"key":"3_CR1","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1111\/j.1742-4658.2010.07830.x","volume":"277","author":"R Abane","year":"2010","unstructured":"Abane R, Mezger V (2010) Roles of heat shock factors in gametogenesis and development. FEBS J 277:4150\u20134172","journal-title":"FEBS J"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.biopha.2008.07.052","volume":"62","author":"A Agarwal","year":"2008","unstructured":"Agarwal A, Desai NR, Ruffoli R, Carpi A (2008) Lifestyle and testicular dysfunction: a brief update. Biomed Pharmacother 62:550\u2013553. doi: 10.1016\/j.biopha.2008.07.052","journal-title":"Biomed Pharmacother"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"5608","DOI":"10.1128\/MCB.01506-09","volume":"30","author":"JK Ahlskog","year":"2010","unstructured":"Ahlskog JK, Bj\u00f6rk JK, Elsing AN, Aspelin C, Kallio M, Roos-Mattjus P, Sistonen L (2010) Anaphase-promoting complex\/cyclosome participates in the acute response to protein-damaging stress. Mol Cell Biol 30:5608\u20135620. doi: 10.1128\/MCB.01506-09","journal-title":"Mol Cell Biol"},{"key":"3_CR4","doi-asserted-by":"publisher","first-page":"11224","DOI":"10.1073\/pnas.0800620105","volume":"105","author":"M Akerfelt","year":"2008","unstructured":"Akerfelt M, Henriksson E, Laiho A, Vihervaara A, Rautoma K, Kotaja N, Sistonen L (2008) Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2. Proc Natl Acad Sci USA 105:11224\u201311229. doi: 10.1073\/pnas.0800620105","journal-title":"Proc Natl Acad Sci USA"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"34469","DOI":"10.1074\/jbc.M110.157552","volume":"285","author":"M Akerfelt","year":"2010","unstructured":"Akerfelt M, Vihervaara A, Laiho A, Conter A, Christians ES, Sistonen L, Henriksson E (2010) Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression. J Biol Chem 285:34469\u201334476. doi: 10.1074\/jbc.M110.157552","journal-title":"J Biol Chem"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1006\/excr.1997.3926","volume":"240","author":"TP Alastalo","year":"1998","unstructured":"Alastalo TP, L\u00f6nnstr\u00f6m M, Lepp\u00e4 S, Kaarniranta K, Pelto-Huikko M, Sistonen L, Parvinen M (1998) Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium. Exp Cell Res 240:16\u201327. doi: 10.1006\/excr.1997.3926","journal-title":"Exp Cell Res"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.1242\/jcs.00671","volume":"116","author":"T-P Alastalo","year":"2003","unstructured":"Alastalo T-P, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L (2003) Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. J Cell Sci 116:3557\u20133570. doi: 10.1242\/jcs.00671","journal-title":"J Cell Sci"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1016\/j.febslet.2013.05.016","volume":"587","author":"G Balogh","year":"2013","unstructured":"Balogh G, P\u00e9ter M, Glatz A, Gombos I, T\u00f6r\u00f6k Z, Horv\u00e1th I, Harwood JL, V\u00edgh L (2013) Key role of lipids in heat stress management. FEBS Lett 587:1970\u20131980. doi: 10.1016\/j.febslet.2013.05.016","journal-title":"FEBS Lett"},{"key":"3_CR9","first-page":"47","volume":"6","author":"A Barqawi","year":"2004","unstructured":"Barqawi A, Trummer H, Meacham R (2004) Effect of prolonged cryptorchidism on germ cell apoptosis and testicular sperm count. Asian J Androl 6:47\u201351","journal-title":"Asian J Androl"},{"key":"3_CR10","first-page":"696","volume":"5","author":"BK Bhowmick","year":"2006","unstructured":"Bhowmick BK, Takahata N, Watanabe M, Satta Y (2006) Comparative analysis of human masculinity. Genet Mol Res 5:696\u2013712","journal-title":"Genet Mol Res"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1242\/dev.050955","volume":"137","author":"JK Bj\u00f6rk","year":"2010","unstructured":"Bj\u00f6rk JK, Sandqvist A, Elsing AN, Kotaja N, Sistonen L (2010) miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis. Dev Camb Engl 137:3177\u20133184. doi: 10.1242\/dev.050955","journal-title":"Dev Camb Engl"},{"key":"3_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/3-540-29446-5_1","volume":"181","author":"R Brehm","year":"2005","unstructured":"Brehm R, Steger K (2005) Regulation of Sertoli cell and germ cell differentiation. Adv Anat Embryol Cell Biol 181:1\u201393","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"3_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s10495-005-0813-7","volume":"10","author":"SP Chaki","year":"2005","unstructured":"Chaki SP, Misro MM, Ghosh D, Gautam DK, Srinivas M (2005) Apoptosis and cell removal in the cryptorchid rat testis. Apoptosis Int J Program Cell Death 10:395\u2013405. doi: 10.1007\/s10495-005-0813-7","journal-title":"Apoptosis Int J Program Cell Death"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1093\/humrep\/des301","volume":"27","author":"F Chalmel","year":"2012","unstructured":"Chalmel F, Lardenois A, Evrard B, Mathieu R, Feig C, Demougin P, Gattiker A, Schulze W, J\u00e9gou B, Kirchhoff C, Primig M (2012) Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility. Hum Reprod 27:3233\u20133248. doi: 10.1093\/humrep\/des301","journal-title":"Hum Reprod"},{"key":"3_CR15","doi-asserted-by":"crossref","unstructured":"Christians ES, Benjamin IJ (2006) Heat shock response: lessons from mouse knockouts. Handb Exp Pharmacol 172:139\u2013152","DOI":"10.1007\/3-540-29717-0_6"},{"key":"3_CR16","first-page":"113","volume":"121","author":"E Christians","year":"1995","unstructured":"Christians E, Campion E, Thompson EM, Renard JP (1995) Expression of the HSP 70.1 gene, a landmark of early zygotic activity in the mouse embryo, is restricted to the first burst of transcription. Dev Camb Engl 121:113\u2013122","journal-title":"Dev Camb Engl"},{"key":"3_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-00513-8_1","volume":"205","author":"MS Davidoff","year":"2009","unstructured":"Davidoff MS, Middendorff R, M\u00fcller D, Holstein AF (2009) The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes. Adv Anat Embryol Cell Biol 205:1\u2013107","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/humupd\/dms009","volume":"18","author":"MD Dun","year":"2012","unstructured":"Dun MD, Aitken RJ, Nixon B (2012) The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa. Hum Reprod Update 18:420\u2013435. doi: 10.1093\/humupd\/dms009","journal-title":"Hum Reprod Update"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1093\/hmg\/ddi304","volume":"14","author":"PJI Ellis","year":"2005","unstructured":"Ellis PJI, Clemente EJ, Ball P, Tour\u00e9 A, Ferguson L, Turner JMA, Loveland KL, Affara NA, Burgoyne PS (2005) Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids. Hum Mol Genet 14:2705\u20132715. doi: 10.1093\/hmg\/ddi304","journal-title":"Hum Mol Genet"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1083\/jcb.201402002","volume":"206","author":"AN Elsing","year":"2014","unstructured":"Elsing AN, Aspelin C, Bj\u00f6rk JK, Bergman HA, Himanen SV, Kallio MJ, Roos-Mattjus P, Sistonen L (2014) Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival. J Cell Biol 206:735\u2013749. doi: 10.1083\/jcb.201402002","journal-title":"J Cell Biol"},{"key":"3_CR21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/nar\/23.3.467","volume":"23","author":"MT Fiorenza","year":"1995","unstructured":"Fiorenza MT, Farkas T, Dissing M, Kolding D, Zimarino V (1995) Complex expression of murine heat shock transcription factors. Nucleic Acids Res 23:467\u2013474","journal-title":"Nucleic Acids Res"},{"key":"3_CR22","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1111\/j.1742-4658.2010.07827.x","volume":"277","author":"M Fujimoto","year":"2010","unstructured":"Fujimoto M, Nakai A (2010) The heat shock factor family and adaptation to proteotoxic stress. FEBS J 277:4112\u20134125","journal-title":"FEBS J"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"4297","DOI":"10.1038\/sj.emboj.7600435","volume":"23","author":"M Fujimoto","year":"2004","unstructured":"Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S-I, Kato K, Yonemura S, Inouye S, Nakai A (2004) HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J 23:4297\u20134306. doi: 10.1038\/sj.emboj.7600435","journal-title":"EMBO J"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1091\/mbc.E09-07-0639","volume":"21","author":"M Fujimoto","year":"2010","unstructured":"Fujimoto M, Hayashida N, Katoh T, Oshima K, Shinkawa T, Prakasam R, Tan K, Inouye S, Takii R, Nakai A (2010) A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock. Mol Biol Cell 21:106\u2013116. doi: 10.1091\/mbc.E09-07-0639","journal-title":"Mol Biol Cell"},{"key":"3_CR25","first-page":"357","volume":"37","author":"A Gasinska","year":"1990","unstructured":"Gasinska A, Hill S (1990) The effect of hyperthermia on the mouse testis. Neoplasma 37:357\u2013366","journal-title":"Neoplasma"},{"key":"3_CR26","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1128\/MCB.15.10.5288","volume":"15","author":"ML Goodson","year":"1995","unstructured":"Goodson ML, Park-Sarge OK, Sarge KD (1995) Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities. Mol Cell Biol 15:5288\u20135293","journal-title":"Mol Cell Biol"},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"9322","DOI":"10.1074\/jbc.M209412200","volume":"278","author":"LQ Gothard","year":"2003","unstructured":"Gothard LQ, Ruffner ME, Woodward JG, Park-Sarge O-K, Sarge KD (2003) Lowered temperature set point for activation of the cellular stress response in T-lymphocytes. J Biol Chem 278:9322\u20139326. doi: 10.1074\/jbc.M209412200","journal-title":"J Biol Chem"},{"key":"3_CR28","doi-asserted-by":"publisher","first-page":"4773","DOI":"10.1038\/sj.emboj.7601370","volume":"25","author":"N Hayashida","year":"2006","unstructured":"Hayashida N, Inouye S, Fujimoto M, Tanaka Y, Izu H, Takaki E, Ichikawa H, Rho J, Nakai A (2006) A novel HSF1-mediated death pathway that is suppressed by heat shock proteins. EMBO J 25:4773\u20134783. doi: 10.1038\/sj.emboj.7601370","journal-title":"EMBO J"},{"key":"3_CR29","doi-asserted-by":"publisher","first-page":"35465","DOI":"10.1074\/jbc.M304663200","volume":"278","author":"H He","year":"2003","unstructured":"He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK (2003) Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. J Biol Chem 278:35465\u201335475. doi: 10.1074\/jbc.M304663200","journal-title":"J Biol Chem"},{"key":"3_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067566","volume":"8","author":"G Herbomel","year":"2013","unstructured":"Herbomel G, Kloster-Landsberg M, Folco EG, Col E, Usson Y, Vourc\u2019h C, Delon A, Souchier C (2013) Dynamics of the full length and mutated heat shock factor 1 in human cells. PLoS One 8:e67566. doi: 10.1371\/journal.pone.0067566","journal-title":"PLoS One"},{"key":"3_CR31","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1210\/en.2003-0175","volume":"144","author":"APS Hikim","year":"2003","unstructured":"Hikim APS, Lue Y, Yamamoto CM, Vera Y, Rodriguez S, Yen PH, Soeng K, Wang C, Swerdloff RS (2003) Key apoptotic pathways for heat-induced programmed germ cell death in the testis. Endocrinology 144:3167\u20133175. doi: 10.1210\/en.2003-0175","journal-title":"Endocrinology"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"8575","DOI":"10.1128\/MCB.21.24.8575-8591.2001","volume":"21","author":"L Huang","year":"2001","unstructured":"Huang L, Mivechi NF, Moskophidis D (2001) Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene. Mol Cell Biol 21:8575\u20138591. doi: 10.1128\/MCB.21.24.8575-8591.2001","journal-title":"Mol Cell Biol"},{"key":"3_CR33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1095\/biolreprod.103.020065","volume":"70","author":"H Izu","year":"2004","unstructured":"Izu H, Inouye S, Fujimoto M, Shiraishi K, Naito K, Nakai A (2004) Heat shock transcription factor 1 is involved in quality-control mechanisms in male germ cells. Biol Reprod 70:18\u201324. doi: 10.1095\/biolreprod.103.020065","journal-title":"Biol Reprod"},{"key":"3_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S2305-0500(13)60053-6","volume":"1","author":"Z-L Ji","year":"2012","unstructured":"Ji Z-L, Duan Y-G, Mou L-S, Allam J-P, Haidl G, Cai Z-M (2012) Association of heat shock proteins, heat shock factors and male infertility. Asian Pac J Reprod 1:76\u201384. doi: 10.1016\/S2305-0500(13)60053-6","journal-title":"Asian Pac J Reprod"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1093\/emboj\/21.11.2591","volume":"21","author":"M Kallio","year":"2002","unstructured":"Kallio M, Chang Y, Manuel M, Alastalo T-P, Rallu M, Gitton Y, Pirkkala L, Loones M-T, Paslaru L, Larney S, Hiard S, Morange M, Sistonen L, Mezger V (2002) Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice. EMBO J 21:2591\u20132601. doi: 10.1093\/emboj\/21.11.2591","journal-title":"EMBO J"},{"key":"3_CR36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s12192-008-0068-7","volume":"14","author":"HH Kampinga","year":"2009","unstructured":"Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE (2009) Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones 14:105\u2013111. doi: 10.1007\/s12192-008-0068-7","journal-title":"Cell Stress Chaperones"},{"key":"3_CR37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1379\/1466-1268(2002)007<0073:TEOHOT>2.0.CO;2","volume":"7","author":"VR Khan","year":"2002","unstructured":"Khan VR, Brown IR (2002) The effect of hyperthermia on the induction of cell death in brain, testis, and thymus of the adult and developing rat. Cell Stress Chaperones 7:73\u201390","journal-title":"Cell Stress Chaperones"},{"key":"3_CR38","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/humrep\/der421","volume":"27","author":"E Kichine","year":"2012","unstructured":"Kichine E, Roz\u00e9 V, Di Cristofaro J, Taulier D, Navarro A, Streichemberger E, Decarpentrie F, Metzler-Guillemain C, L\u00e9vy N, Chiaroni J, Paquis-Flucklinger V, Fellmann F, Mitchell MJ (2012) HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. Hum Reprod Oxf Engl 27:615\u2013624. doi: 10.1093\/humrep\/der421","journal-title":"Hum Reprod Oxf Engl"},{"key":"3_CR39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2152\/jmi.53.117","volume":"53","author":"K Kinoshita","year":"2006","unstructured":"Kinoshita K, Shinka T, Sato Y, Kurahashi H, Kowa H, Chen G, Umeno M, Toida K, Kiyokage E, Nakano T, Ito S, Nakahori Y (2006) Expression analysis of a mouse orthologue of HSFY, a candidate for the azoospermic factor on the human Y chromosome. J Med Investig 53:117\u2013122","journal-title":"J Med Investig"},{"key":"3_CR40","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.biocel.2014.10.006","volume":"57C","author":"J Korfanty","year":"2014","unstructured":"Korfanty J, Stokowy T, Widlak P, Gogler-Piglowska A, Handschuh L, Podkowi\u0144ski J, Vydra N, Naumowicz A, Toma-Jonik A, Widlak W (2014) Crosstalk between HSF1 and HSF2 during the heat shock response in mouse testes. Int J Biochem Cell Biol 57C:76\u201383. doi: 10.1016\/j.biocel.2014.10.006","journal-title":"Int J Biochem Cell Biol"},{"key":"3_CR41","first-page":"76","volume":"282","author":"J Korfanty","year":"2015","unstructured":"Korfanty J, Toma-Jonik A, Naumowicz A, Vydra N, Widlak W (2015) Mechanism of atypical pro-death signalling mediated by the Heat Shock Factor 1. FEBS J 282:76\u201377","journal-title":"FEBS J"},{"key":"3_CR42","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nmeth1204-249","volume":"1","author":"N Kotaja","year":"2004","unstructured":"Kotaja N, Kimmins S, Brancorsini S, Hentsch D, Vonesch J-L, Davidson I, Parvinen M, Sassone-Corsi P (2004) Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis. Nat Methods 1:249\u2013254. doi: 10.1038\/nmeth1204-249","journal-title":"Nat Methods"},{"key":"3_CR43","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1186\/1471-2164-14-456","volume":"14","author":"M Kus-Li\u015bkiewicz","year":"2013","unstructured":"Kus-Li\u015bkiewicz M, Pola\u0144ska J, Korfanty J, Olbryt M, Vydra N, Toma A, Wid\u0142ak W (2013) Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia. BMC Genomics 14:456. doi: 10.1186\/1471-2164-14-456","journal-title":"BMC Genomics"},{"key":"3_CR44","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1042\/BJ20051190","volume":"395","author":"F Loison","year":"2006","unstructured":"Loison F, Debure L, Nizard P, le Goff P, Michel D, le Dr\u00e9an Y (2006) Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes. Biochem J 395:223\u2013231. doi: 10.1042\/BJ20051190","journal-title":"Biochem J"},{"key":"3_CR45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-4684-5913-5_17","volume":"286","author":"KR Loughlin","year":"1991","unstructured":"Loughlin KR, Manson K, Foreman R, Schwartz B, Heuttner P (1991) The effect of intermittent scrotal hyperthermia on the Sprague-Dawley rat testicle. Adv Exp Med Biol 286:183\u2013185","journal-title":"Adv Exp Med Biol"},{"key":"3_CR46","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1210\/endo.140.4.6629","volume":"140","author":"YH Lue","year":"1999","unstructured":"Lue YH, Hikim AP, Swerdloff RS, Im P, Taing KS, Bui T, Leung A, Wang C (1999) Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity. Endocrinology 140:1709\u20131717. doi: 10.1210\/endo.140.4.6629","journal-title":"Endocrinology"},{"key":"3_CR47","doi-asserted-by":"publisher","first-page":"7163","DOI":"10.1128\/MCB.21.21.7163-7171.2001","volume":"21","author":"A Mathew","year":"2001","unstructured":"Mathew A, Mathur SK, Jolly C, Fox SG, Kim S, Morimoto RI (2001) Stress-specific activation and repression of heat shock factors 1 and 2. Mol Cell Biol 21:7163\u20137171. doi: 10.1128\/MCB.21.21.7163-7171.2001","journal-title":"Mol Cell Biol"},{"key":"3_CR48","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1074\/jbc.273.13.7523","volume":"273","author":"DR McMillan","year":"1998","unstructured":"McMillan DR, Xiao X, Shao L, Graves K, Benjamin IJ (1998) Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem 273:7523\u20137528","journal-title":"J Biol Chem"},{"key":"3_CR49","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00439-012-1234-7","volume":"132","author":"L Mou","year":"2013","unstructured":"Mou L, Wang Y, Li H, Huang Y, Jiang T, Huang W, Li Z, Chen J, Xie J, Liu Y, Jiang Z, Li X, Ye J, Cai Z, Gui Y (2013) A dominant-negative mutation of HSF2 associated with idiopathic azoospermia. Hum Genet 132:159\u2013165. doi: 10.1007\/s00439-012-1234-7","journal-title":"Hum Genet"},{"key":"3_CR50","doi-asserted-by":"publisher","first-page":"34665","DOI":"10.1074\/jbc.M005302200","volume":"275","author":"A Nakai","year":"2000","unstructured":"Nakai A, Ishikawa T (2000) A nuclear localization signal is essential for stress-induced dimer-to-trimer transition of heat shock transcription factor 3. J Biol Chem 275:34665\u201334671. doi: 10.1074\/jbc.M005302200","journal-title":"J Biol Chem"},{"key":"3_CR51","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1128\/MCB.17.1.469","volume":"17","author":"A Nakai","year":"1997","unstructured":"Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K (1997) HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol 17:469\u2013481","journal-title":"Mol Cell Biol"},{"key":"3_CR52","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1093\/emboj\/19.7.1545","volume":"19","author":"A Nakai","year":"2000","unstructured":"Nakai A, Suzuki M, Tanabe M (2000) Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J 19:1545\u20131554. doi: 10.1093\/emboj\/19.7.1545","journal-title":"EMBO J"},{"key":"3_CR53","doi-asserted-by":"publisher","first-page":"19894","DOI":"10.1074\/jbc.M114.570739","volume":"289","author":"A Neueder","year":"2014","unstructured":"Neueder A, Achilli F, Moussaoui S, Bates GP (2014) Novel isoforms of heat shock transcription factor 1, HSF1\u03b3\u03b1 and HSF1\u03b3\u03b2, regulate chaperone protein gene transcription. J Biol Chem 289:19894\u201319906. doi: 10.1074\/jbc.M114.570739","journal-title":"J Biol Chem"},{"key":"3_CR54","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1126\/science.288.5468.1053","volume":"288","author":"E Oda","year":"2000","unstructured":"Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053\u20131058","journal-title":"Science"},{"key":"3_CR55","doi-asserted-by":"publisher","first-page":"7077","DOI":"10.1074\/jbc.M607556200","volume":"282","author":"P Ostling","year":"2007","unstructured":"Ostling P, Bj\u00f6rk JK, Roos-Mattjus P, Mezger V, Sistonen L (2007) Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. J Biol Chem 282:7077\u20137086. doi: 10.1074\/jbc.M607556200","journal-title":"J Biol Chem"},{"key":"3_CR56","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3892\/ijmm.2015.2309","volume":"36","author":"S-M Park","year":"2015","unstructured":"Park S-M, Kim S-A, Ahn S-G (2015) HSF2 autoregulates its own transcription. Int J Mol Med 36:1173\u20131179. doi: 10.3892\/ijmm.2015.2309","journal-title":"Int J Mol Med"},{"key":"3_CR57","first-page":"1118","volume":"15","author":"L Pirkkala","year":"2001","unstructured":"Pirkkala L, Nyk\u00e4nen P, Sistonen L (2001) Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J Off Publ Fed Am Soc Exp Biol 15:1118\u20131131","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"issue":"Suppl 1","key":"3_CR58","doi-asserted-by":"publisher","first-page":"S84","DOI":"10.1038\/onc.2009.46","volume":"27","author":"C Ploner","year":"2008","unstructured":"Ploner C, Kofler R, Villunger A (2008) Noxa: at the tip of the balance between life and death. Oncogene 27(Suppl 1):S84\u2013S92. doi: 10.1038\/onc.2009.46","journal-title":"Oncogene"},{"key":"3_CR59","doi-asserted-by":"publisher","first-page":"668","DOI":"10.4103\/1008-682X.146967","volume":"17","author":"M Rao","year":"2015","unstructured":"Rao M, Zhao X-L, Yang J, Hu S-F, Lei H, Xia W, Zhu C-H (2015) Effect of transient scrotal hyperthermia on sperm parameters, seminal plasma biochemical markers, and oxidative stress in men. Asian J Androl 17:668\u2013675. doi: 10.4103\/1008-682X.146967","journal-title":"Asian J Androl"},{"key":"3_CR60","first-page":"4453","volume":"41","author":"BO Reid","year":"1981","unstructured":"Reid BO, Mason KA, Withers HR, West J (1981) Effects of hyperthermia and radiation on mouse testis stem cells. Cancer Res 41:4453\u20134457","journal-title":"Cancer Res"},{"key":"3_CR61","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.molcel.2010.10.006","volume":"40","author":"K Richter","year":"2010","unstructured":"Richter K, Haslbeck M, Buchner J (2010) The heat shock response: life on the verge of death. Mol Cell 40:253\u2013266. doi: 10.1016\/j.molcel.2010.10.006","journal-title":"Mol Cell"},{"key":"3_CR62","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1095\/biolreprod65.1.229","volume":"65","author":"JC Rockett","year":"2001","unstructured":"Rockett JC, Mapp FL, Garges JB, Luft JC, Mori C, Dix DJ (2001) Effects of hyperthermia on spermatogenesis, apoptosis, gene expression, and fertility in adult male mice. Biol Reprod 65:229\u2013239","journal-title":"Biol Reprod"},{"key":"3_CR63","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.cbpa.2011.04.002","volume":"159","author":"W Rupik","year":"2011","unstructured":"Rupik W, Jasik K, Bembenek J, Wid\u0142ak W (2011) The expression patterns of heat shock genes and proteins and their role during vertebrate\u2019s development. Comp Biochem Physiol A Mol Integr Physiol 159:349\u2013366. doi: 10.1016\/j.cbpa.2011.04.002","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"3_CR64","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1095\/biolreprod.108.070334","volume":"79","author":"PA Salmand","year":"2008","unstructured":"Salmand PA, Jungas T, Fernandez M, Conter A, Christians ES (2008) Mouse heat-shock factor 1 (HSF1) is involved in testicular response to genotoxic stress induced by doxorubicin. Biol Reprod 79:1092\u20131101. doi: 10.1095\/biolreprod.108.070334","journal-title":"Biol Reprod"},{"key":"3_CR65","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1091\/mbc.E08-08-0864","volume":"20","author":"A Sandqvist","year":"2009","unstructured":"Sandqvist A, Bj\u00f6rk JK, Akerfelt M, Chitikova Z, Grichine A, Vourc\u2019h C, Jolly C, Salminen TA, Nymalm Y, Sistonen L (2009) Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. Mol Biol Cell 20:1340\u20131347. doi: 10.1091\/mbc.E08-08-0864","journal-title":"Mol Biol Cell"},{"key":"3_CR66","doi-asserted-by":"crossref","first-page":"18745","DOI":"10.1074\/jbc.270.32.18745","volume":"270","author":"KD Sarge","year":"1995","unstructured":"Sarge KD (1995) Male germ cell-specific alteration in temperature set point of the cellular stress response. J Biol Chem 270:18745\u201318748","journal-title":"J Biol Chem"},{"key":"3_CR67","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1101\/gad.5.10.1902","volume":"5","author":"KD Sarge","year":"1991","unstructured":"Sarge KD, Zimarino V, Holm K, Wu C, Morimoto RI (1991) Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev 5:1902\u20131911","journal-title":"Genes Dev"},{"key":"3_CR68","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1095\/biolreprod50.6.1334","volume":"50","author":"KD Sarge","year":"1994","unstructured":"Sarge KD, Park-Sarge OK, Kirby JD, Mayo KE, Morimoto RI (1994) Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biol Reprod 50:1334\u20131343","journal-title":"Biol Reprod"},{"key":"3_CR69","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.fertnstert.2006.01.053","volume":"86","author":"Y Sato","year":"2006","unstructured":"Sato Y, Yoshida K, Shinka T, Nozawa S, Nakahori Y, Iwamoto T (2006) Altered expression pattern of heat shock transcription factor, Y chromosome (HSFY) may be related to altered differentiation of spermatogenic cells in testes with deteriorated spermatogenesis. Fertil Steril 86:612\u2013618. doi: 10.1016\/j.fertnstert.2006.01.053","journal-title":"Fertil Steril"},{"key":"3_CR70","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s12192-014-0548-x","volume":"20","author":"D Scieglinska","year":"2015","unstructured":"Scieglinska D, Krawczyk Z (2015) Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans. Cell Stress Chaperones 20:221\u2013235. doi: 10.1007\/s12192-014-0548-x","journal-title":"Cell Stress Chaperones"},{"key":"3_CR71","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1095\/biolreprod.103.023580","volume":"71","author":"T Shinka","year":"2004","unstructured":"Shinka T, Sato Y, Chen G, Naroda T, Kinoshita K, Unemi Y, Tsuji K, Toida K, Iwamoto T, Nakahori Y (2004) Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. Biol Reprod 71:297\u2013306. doi: 10.1095\/biolreprod.103.023580","journal-title":"Biol Reprod"},{"key":"3_CR72","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1091\/mbc.E11-04-0330","volume":"22","author":"T Shinkawa","year":"2011","unstructured":"Shinkawa T, Tan K, Fujimoto M, Hayashida N, Yamamoto K, Takaki E, Takii R, Prakasam R, Inouye S, Mezger V, Nakai A (2011) Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation. Mol Biol Cell 22:3571\u20133583. doi: 10.1091\/mbc.E11-04-0330","journal-title":"Mol Biol Cell"},{"key":"3_CR73","doi-asserted-by":"crossref","first-page":"746","DOI":"10.2741\/e415","volume":"4","author":"KK Shukla","year":"2012","unstructured":"Shukla KK, Mahdi AA, Rajender S (2012) Apoptosis, spermatogenesis and male infertility. Front Biosci (Elite Ed) 4:746\u2013754","journal-title":"Front Biosci (Elite Ed)"},{"key":"3_CR74","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1128\/MCB.14.3.2087","volume":"14","author":"L Sistonen","year":"1994","unstructured":"Sistonen L, Sarge KD, Morimoto RI (1994) Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Mol Cell Biol 14:2087\u20132099","journal-title":"Mol Cell Biol"},{"key":"3_CR75","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1152\/physrev.00017.2015","volume":"96","author":"NE Skakkebaek","year":"2016","unstructured":"Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, Toppari J, Andersson A-M, Eisenberg ML, Jensen TK, J\u00f8rgensen N, Swan SH, Sapra KJ, Ziebe S, Priskorn L, Juul A (2016) Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev 96:55\u201397. doi: 10.1152\/physrev.00017.2015","journal-title":"Physiol Rev"},{"key":"3_CR76","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.fertnstert.2011.05.055","volume":"96","author":"PJ Stahl","year":"2011","unstructured":"Stahl PJ, Mielnik A, Schlegel PN, Paduch DA (2011) Heat shock factor Y chromosome (HSFY) mRNA level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia. Fertil Steril 96:303\u2013308. doi: 10.1016\/j.fertnstert.2011.05.055","journal-title":"Fertil Steril"},{"key":"3_CR77","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/cdd.2008.189","volume":"16","author":"AR Stankiewicz","year":"2009","unstructured":"Stankiewicz AR, Livingstone AM, Mohseni N, Mosser DD (2009) Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. Cell Death Differ 16:638\u2013647. doi: 10.1038\/cdd.2008.189","journal-title":"Cell Death Differ"},{"key":"3_CR78","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2741\/1864","volume":"11","author":"S-X Tao","year":"2006","unstructured":"Tao S-X, Guo J, Zhang X-S, Li Y-C, Hu Z-Y, Han C-S, Liu Y-X (2006) Germ cell apoptosis induced by experimental cryptorchidism is mediated by multiple molecular pathways in Cynomolgus Macaque. Front Biosci J Virtual Library 11:1077\u20131089","journal-title":"Front Biosci J Virtual Library"},{"key":"3_CR79","first-page":"5","volume":"204","author":"K Toshimori","year":"2009","unstructured":"Toshimori K (2009) Dynamics of the mammalian sperm head: modifications and maturation events from spermatogenesis to egg activation. Adv Anat Embryol Cell Biol 204:5\u201394","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"3_CR80","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1379\/1466-1268(2004)009<0021:TRABOH>2.0.CO;2","volume":"9","author":"ND Trinklein","year":"2004","unstructured":"Trinklein ND, Chen WC, Kingston RE, Myers RM (2004) Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation. Cell Stress Chaperones 9:21\u201328","journal-title":"Cell Stress Chaperones"},{"key":"3_CR81","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1242\/dev.000018","volume":"134","author":"JMA Turner","year":"2007","unstructured":"Turner JMA (2007) Meiotic sex chromosome inactivation. Dev Camb Engl 134:1823\u20131831. doi: 10.1242\/dev.000018","journal-title":"Dev Camb Engl"},{"key":"3_CR82","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhl\u00e9n","year":"2015","unstructured":"Uhl\u00e9n M, Fagerberg L, Hallstr\u00f6m BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson \u00c5, Kampf C, Sj\u00f6stedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA-K, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist P-H, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pont\u00e9n F (2015) Tissue-based map of the human proteome. Science 347:1260419. doi: 10.1126\/science.1260419","journal-title":"Science"},{"key":"3_CR83","doi-asserted-by":"publisher","first-page":"a004390","DOI":"10.1101\/cshperspect.a004390","volume":"2","author":"RM Vabulas","year":"2010","unstructured":"Vabulas RM, Raychaudhuri S, Hayer-Hartl M, Hartl FU (2010) Protein folding in the cytoplasm and the heat shock response. Cold Spring Harb Perspect Biol 2:a004390. doi: 10.1101\/cshperspect.a004390","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3_CR84","doi-asserted-by":"publisher","first-page":"E3388","DOI":"10.1073\/pnas.1305275110","volume":"110","author":"A Vihervaara","year":"2013","unstructured":"Vihervaara A, Sergelius C, Vasara J, Blom MAH, Elsing AN, Roos-Mattjus P, Sistonen L (2013) Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells. Proc Natl Acad Sci USA 110:E3388\u2013E3397. doi: 10.1073\/pnas.1305275110","journal-title":"Proc Natl Acad Sci USA"},{"key":"3_CR85","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1379\/CSC-14R.1","volume":"9","author":"R Voellmy","year":"2004","unstructured":"Voellmy R (2004) On mechanisms that control heat shock transcription factor activity in metazoan cells. Cell Stress Chaperones 9:122\u2013133","journal-title":"Cell Stress Chaperones"},{"key":"3_CR86","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/sj.cdd.4401758","volume":"13","author":"N Vydra","year":"2006","unstructured":"Vydra N, Malusecka E, Jarzab M, Lisowska K, Glowala-Kosinska M, Benedyk K, Widlak P, Krawczyk Z, Widlak W (2006) Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells. Cell Death Differ 13:212\u2013222. doi: 10.1038\/sj.cdd.4401758","journal-title":"Cell Death Differ"},{"key":"3_CR87","doi-asserted-by":"publisher","first-page":"144","DOI":"10.2174\/1568009614666140122155942","volume":"14","author":"N Vydra","year":"2014","unstructured":"Vydra N, Toma A, Widlak W (2014) Pleiotropic role of HSF1 in neoplastic transformation. Curr Cancer Drug Targets 14:144\u2013155. doi: 10.2174\/1568009614666140122155942","journal-title":"Curr Cancer Drug Targets"},{"key":"3_CR88","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/gene.10200","volume":"36","author":"G Wang","year":"2003","unstructured":"Wang G, Zhang J, Moskophidis D, Mivechi NF (2003) Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis 36:48\u201361. doi: 10.1002\/gene.10200","journal-title":"Genesis"},{"key":"3_CR89","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/gene.20005","volume":"38","author":"G Wang","year":"2004","unstructured":"Wang G, Ying Z, Jin X, Tu N, Zhang Y, Phillips M, Moskophidis D, Mivechi NF (2004) Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility. Genesis 38:66\u201380. doi: 10.1002\/gene.20005","journal-title":"Genesis"},{"key":"3_CR90","doi-asserted-by":"crossref","first-page":"535","DOI":"10.18388\/abp.2003_3706","volume":"50","author":"W Wid\u0142ak","year":"2003","unstructured":"Wid\u0142ak W, Benedyk K, Vydra N, G\u0142owala M, Sciegli\u0144ska D, Ma\u0142usecka E, Nakai A, Krawczyk Z (2003) Expression of a constitutively active mutant of heat shock factor 1 under the control of testis-specific hst70 gene promoter in transgenic mice induces degeneration of seminiferous epithelium. Acta Biochim Pol 50:535\u2013541, 035002535","journal-title":"Acta Biochim Pol"},{"key":"3_CR91","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1365-2443.2007.01069.x","volume":"12","author":"W Widlak","year":"2007","unstructured":"Widlak W, Vydra N, Malusecka E, Dudaladava V, Winiarski B, Sciegli\u0144ska D, Widlak P (2007a) Heat shock transcription factor 1 down-regulates spermatocyte-specific 70\u00a0kDa heat shock protein expression prior to the induction of apoptosis in mouse testes. Genes Cells Devoted Mol Cell Mech 12:487\u2013499. doi: 10.1111\/j.1365-2443.2007.01069.x","journal-title":"Genes Cells Devoted Mol Cell Mech"},{"key":"3_CR92","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1365-2605.2006.00713.x","volume":"30","author":"W Widlak","year":"2007","unstructured":"Widlak W, Winiarski B, Krawczyk A, Vydra N, Malusecka E, Krawczyk Z (2007b) Inducible 70\u00a0kDa heat shock protein does not protect spermatogenic cells from damage induced by cryptorchidism. Int J Androl 30:80\u201387. doi: 10.1111\/j.1365-2605.2006.00713.x","journal-title":"Int J Androl"},{"key":"3_CR93","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1095\/biolreprod.107.066241","volume":"79","author":"DC Wilkerson","year":"2008","unstructured":"Wilkerson DC, Murphy LA, Sarge KD (2008) Interaction of HSF1 and HSF2 with the Hspa1b promoter in mouse epididymal spermatozoa. Biol Reprod 79:283\u2013288. doi: 10.1095\/biolreprod.107.066241","journal-title":"Biol Reprod"},{"key":"3_CR94","doi-asserted-by":"publisher","first-page":"D313","DOI":"10.1093\/nar\/gkv1104","volume":"44","author":"C Wu","year":"2016","unstructured":"Wu C, Jin X, Tsueng G, Afrasiabi C, Su AI (2016) BioGPS: building your own mash-up of gene annotations and expression profiles. Nucleic Acids Res 44:D313\u2013D316. doi: 10.1093\/nar\/gkv1104","journal-title":"Nucleic Acids Res"},{"key":"3_CR95","doi-asserted-by":"publisher","first-page":"5943","DOI":"10.1093\/emboj\/18.21.5943","volume":"18","author":"X Xiao","year":"1999","unstructured":"Xiao X, Zuo X, Davis AA, McMillan DR, Curry BB, Richardson JA, Benjamin IJ (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18:5943\u20135952. doi: 10.1093\/emboj\/18.21.5943","journal-title":"EMBO J"},{"key":"3_CR96","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1106478","volume":"307","author":"H Xing","year":"2005","unstructured":"Xing H, Wilkerson DC, Mayhew CN, Lubert EJ, Skaggs HS, Goodson ML, Hong Y, Park-Sarge O-K, Sarge KD (2005) Mechanism of hsp70i gene bookmarking. Science 307:421\u2013423. doi: 10.1126\/science.1106478","journal-title":"Science"},{"key":"3_CR97","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1021\/pr201151a","volume":"11","author":"Y-M Xu","year":"2012","unstructured":"Xu Y-M, Huang D-Y, Chiu J-F, Lau ATY (2012) Post-translational modification of human heat shock factors and their functions: a recent update by proteomic approach. J Proteome Res 11:2625\u20132634. doi: 10.1021\/pr201151a","journal-title":"J Proteome Res"},{"key":"3_CR98","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1095\/biolreprod63.6.1683","volume":"63","author":"CM Yamamoto","year":"2000","unstructured":"Yamamoto CM, Sinha Hikim AP, Huynh PN, Shapiro B, Lue Y, Salameh WA, Wang C, Swerdloff RS (2000) Redistribution of Bax is an early step in an apoptotic pathway leading to germ cell death in rats, triggered by mild testicular hyperthermia. Biol Reprod 63:1683\u20131690","journal-title":"Biol Reprod"},{"key":"3_CR99","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1111\/j.1742-4658.2009.06923.x","volume":"276","author":"N Yamamoto","year":"2009","unstructured":"Yamamoto N, Takemori Y, Sakurai M, Sugiyama K, Sakurai H (2009) Differential recognition of heat shock elements by members of the heat shock transcription factor family. FEBS J 276:1962\u20131974. doi: 10.1111\/j.1742-4658.2009.06923.x","journal-title":"FEBS J"},{"key":"3_CR100","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/mrd.22318","volume":"81","author":"L Yang","year":"2014","unstructured":"Yang L, Wang Y, Zhang Q, Lai Y, Li C, Zhang Q, Huang W, Duan Y, Jiang Z, Li X, Cai Z, Mou L, Gui Y (2014) Identification of Hsf1 as a novel androgen receptor-regulated gene in mouse Sertoli cells. Mol Reprod Dev 81:514\u2013523. doi: 10.1002\/mrd.22318","journal-title":"Mol Reprod Dev"},{"key":"3_CR101","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/j.1939-4640.1997.tb01896.x","volume":"18","author":"Y Yin","year":"1997","unstructured":"Yin Y, Hawkins KL, DeWolf WC, Morgentaler A (1997) Heat stress causes testicular germ cell apoptosis in adult mice. J Androl 18:159\u2013165","journal-title":"J Androl"}],"container-title":["Advances in Anatomy, Embryology and Cell Biology","The Role of Heat Shock Proteins in Reproductive System Development and Function"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-51409-3_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T13:27:11Z","timestamp":1719149231000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-51409-3_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319514086","9783319514093"],"references-count":101,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-51409-3_3","relation":{},"ISSN":["0301-5556","2192-7065"],"issn-type":[{"value":"0301-5556","type":"print"},{"value":"2192-7065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}