{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:08:18Z","timestamp":1793480898611,"version":"4.5.0"},"publisher-location":"Cham","reference-count":87,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319553290","type":"print"},{"value":"9783319553306","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-55330-6_29","type":"book-chapter","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T11:33:41Z","timestamp":1495884821000},"page":"563-575","source":"Crossref","is-referenced-by-count":10,"title":["Prohibitin Signaling at the Kidney Filtration Barrier"],"prefix":"10.1007","author":[{"given":"Christina","family":"Ising","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Brinkkoetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,28]]},"reference":[{"key":"29_CR1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000020511","volume":"6","author":"H Pavenst\u00e4dt","year":"1998","unstructured":"Pavenst\u00e4dt H. The charge for going by foot: modifying the surface of podocytes. Exp Nephrol. 1998;6:98\u2013103.","journal-title":"Exp Nephrol"},{"key":"29_CR2","first-page":"1368","volume":"13","author":"M Elger","year":"1998","unstructured":"Elger M, Kriz W. Podocytes and the development of segmental glomerulosclerosis. Nephrol Dial Transplant Off Publ Eur Dial Transplant Assoc \u2013 Eur Ren Assoc. 1998;13:1368\u201373.","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transplant Assoc \u2013 Eur Ren Assoc"},{"key":"29_CR3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1523-1755.1998.00044.x","volume":"54","author":"W Kriz","year":"1998","unstructured":"Kriz W, Gretz N, Lemley KV. Progression of glomerular diseases: is the podocyte the culprit? Kidney Int. 1998;54:687\u201397.","journal-title":"Kidney Int"},{"key":"29_CR4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ajpath.2012.11.002","volume":"182","author":"M H\u00f6hne","year":"2013","unstructured":"H\u00f6hne M, Ising C, Hagmann H, et al. Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions. Am J Pathol. 2013;182:332\u20138.","journal-title":"Am J Pathol"},{"key":"29_CR5","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/01.ASN.0000054887.42550.14","volume":"14","author":"JA Kreidberg","year":"2003","unstructured":"Kreidberg JA. Podocyte differentiation and glomerulogenesis. J Am Soc Nephrol JASN. 2003;14:806\u201314.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00041552-199907000-00014","volume":"8","author":"W Kriz","year":"1999","unstructured":"Kriz W, Lemley KV. The role of the podocyte in glomerulosclerosis. Curr Opin Nephrol Hypertens. 1999;8:489\u201397.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"29_CR7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00020.2002","volume":"83","author":"H Pavenst\u00e4dt","year":"2003","unstructured":"Pavenst\u00e4dt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev. 2003;83:253\u2013307.","journal-title":"Physiol Rev"},{"key":"29_CR8","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/sj.ki.5000410","volume":"69","author":"SJ Shankland","year":"2006","unstructured":"Shankland SJ. The podocyte\u2019s response to injury: role in proteinuria and glomerulosclerosis. Kidney Int. 2006;69:2131\u201347.","journal-title":"Kidney Int"},{"key":"29_CR9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ki.1994.39","volume":"45","author":"D Kerjaschki","year":"1994","unstructured":"Kerjaschki D. Dysfunctions of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases. Kidney Int. 1994;45:300\u201313.","journal-title":"Kidney Int"},{"key":"29_CR10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00041552-199411000-00001","volume":"3","author":"DJ Salant","year":"1994","unstructured":"Salant DJ. The structural biology of glomerular epithelial cells in proteinuric diseases. Curr Opin Nephrol Hypertens. 1994;3:569\u201374.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"29_CR11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/01.HYP.0000102971.85504.7c","volume":"42","author":"MJ Sarnak","year":"2003","unstructured":"Sarnak MJ, Levey AS, Schoolwerth AC, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension. 2003;42:1050\u201365.","journal-title":"Hypertension"},{"issue":"Suppl 3","key":"29_CR12","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1111\/j.1440-1797.2007.00876.x","volume":"12","author":"K Asanuma","year":"2007","unstructured":"Asanuma K, Yanagida-Asanuma E, Takagi M, et al. The role of podocytes in proteinuria. Nephrol Carlton Vic. 2007;12(Suppl 3):S15\u201320.","journal-title":"Nephrol Carlton Vic"},{"key":"29_CR13","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1053\/ajkd.1998.v32.pm9820470","volume":"32","author":"RN Foley","year":"1998","unstructured":"Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis Off J Natl Kidney Found. 1998;32:S112\u20139.","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"29_CR14","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1097\/01.ASN.0000130167.30769.55","volume":"15","author":"T Benzing","year":"2004","unstructured":"Benzing T. Signaling at the slit diaphragm. J Am Soc Nephrol JASN. 2004;15:1382\u201391.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR15","doi-asserted-by":"crossref","first-page":"17079","DOI":"10.1073\/pnas.0607465103","volume":"103","author":"TB Huber","year":"2006","unstructured":"Huber TB, Schermer B, M\u00fcller RU, et al. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A. 2006;103:17079\u201386.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"29_CR16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ki.2008.650","volume":"75","author":"E Machuca","year":"2009","unstructured":"Machuca E, Hummel A, Nevo F, et al. Clinical and epidemiological assessment of steroid-resistant nephrotic syndrome associated with the NPHS2 R229Q variant. Kidney Int. 2009;75:727\u201335.","journal-title":"Kidney Int"},{"key":"29_CR17","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/4151039a","volume":"415","author":"MB Goodman","year":"2002","unstructured":"Goodman MB, Ernstrom GG, Chelur DS, et al. MEC-2 regulates C. elegans DEG\/ENaC channels needed for mechanosensation. Nature. 2002;415:1039\u201342.","journal-title":"Nature"},{"key":"29_CR18","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nrm2275","volume":"8","author":"SA Detmer","year":"2007","unstructured":"Detmer SA, Chan DC. Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol. 2007;8:870\u20139.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"29_CR19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrm2959","volume":"11","author":"O Schmidt","year":"2010","unstructured":"Schmidt O, Pfanner N, Meisinger C. Mitochondrial protein import: from proteomics to functional mechanisms. Nat Rev Mol Cell Biol. 2010;11:655\u201367.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"29_CR20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201006159","volume":"192","author":"C Osman","year":"2011","unstructured":"Osman C, Voelker DR, Langer T. Making heads or tails of phospholipids in mitochondria. J Cell Biol. 2011;192:7\u201316.","journal-title":"J Cell Biol"},{"key":"29_CR21","doi-asserted-by":"crossref","unstructured":"Xie W, Santulli G, Reiken SR, Yuan Q, Osborne BW, Chen BX, Marks AR. Mitochondrial oxidative stress promotes atrial fibrillation. Sci Rep. 2015;5:11427.","DOI":"10.1038\/srep11427"},{"key":"29_CR22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/IJNRD.S37887","volume":"7","author":"JF O\u2019Toole","year":"2014","unstructured":"O\u2019Toole JF. Renal manifestations of genetic mitochondrial disease. Int J Nephrol Renov Dis. 2014;7:57\u201367.","journal-title":"Int J Nephrol Renov Dis"},{"key":"29_CR23","first-page":"F367","volume":"306","author":"R Che","year":"2014","unstructured":"Che R, Yuan Y, Huang S, et al. Mitochondrial dysfunction in the pathophysiology of renal diseases. Am J Phys Renal Phys. 2014;306:F367\u201378.","journal-title":"Am J Phys Renal Phys"},{"key":"29_CR24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3181\/00379727-112-27961","volume":"112","author":"P Bartlett","year":"1963","unstructured":"Bartlett P, Keegan J, Schaefer H. Mechanism of aminonucleoside-induced nephrosis in the rat. III Kidney mitochondrial phosphorylation and dephosphorylation activity. Proc Soc Exp Biol Med Soc Exp Biol Med N Y N. 1963;112:96\u2013101.","journal-title":"Proc Soc Exp Biol Med Soc Exp Biol Med N Y N"},{"key":"29_CR25","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1681\/ASN.2006080833","volume":"18","author":"F Diomedi-Camassei","year":"2007","unstructured":"Diomedi-Camassei F, Di Giandomenico S, Santorelli FM, et al. COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. J Am Soc Nephrol JASN. 2007;18:2773\u201380.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1086\/510023","volume":"79","author":"LC L\u00f3pez","year":"2006","unstructured":"L\u00f3pez LC, Schuelke M, Quinzii CM, et al. Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am J Hum Genet. 2006;79:1125\u20139.","journal-title":"Am J Hum Genet"},{"key":"29_CR27","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1681\/ASN.V871118","volume":"8","author":"JJ Jansen","year":"1997","unstructured":"Jansen JJ, Maassen JA, van der Woude FJ, et al. Mutation in mitochondrial tRNA(Leu(UUR)) gene associated with progressive kidney disease. J Am Soc Nephrol JASN. 1997;8:1118\u201324.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR28","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1159\/000013406","volume":"18","author":"F Kurogouchi","year":"1998","unstructured":"Kurogouchi F, Oguchi T, Mawatari E, et al. A case of mitochondrial cytopathy with a typical point mutation for MELAS, presenting with severe focal-segmental glomerulosclerosis as main clinical manifestation. Am J Nephrol. 1998;18:551\u20136.","journal-title":"Am J Nephrol"},{"key":"29_CR29","doi-asserted-by":"crossref","first-page":"R185","DOI":"10.1093\/hmg\/ddp328","volume":"18","author":"E Machuca","year":"2009","unstructured":"Machuca E, Benoit G, Antignac C. Genetics of nephrotic syndrome: connecting molecular genetics to podocyte physiology. Hum Mol Genet. 2009;18:R185\u201394.","journal-title":"Hum Mol Genet"},{"key":"29_CR30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1523-1755.2004.00702.x","volume":"66","author":"M Peng","year":"2004","unstructured":"Peng M, Jarett L, Meade R, et al. Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd\/kd mice. Kidney Int. 2004;66:20\u20138.","journal-title":"Kidney Int"},{"key":"29_CR31","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.ki.5000207","volume":"69","author":"M Hagiwara","year":"2006","unstructured":"Hagiwara M, Yamagata K, Capaldi RA, et al. Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis. Kidney Int. 2006;69:1146\u201352.","journal-title":"Kidney Int"},{"key":"29_CR32","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.2337\/diabetes.51.5.1588","volume":"51","author":"M Kakimoto","year":"2002","unstructured":"Kakimoto M, Inoguchi T, Sonta T, et al. Accumulation of 8-hydroxy-2\u2032-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats. Diabetes. 2002;51:1588\u201395.","journal-title":"Diabetes"},{"key":"29_CR33","first-page":"523","volume":"13","author":"H Holth\u00f6fer","year":"1999","unstructured":"Holth\u00f6fer H, Kretzler M, Haltia A, et al. Altered gene expression and functions of mitochondria in human nephrotic syndrome. FASEB J Off Publ Fed Am Soc Exp Biol. 1999;13:523\u201332.","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"29_CR34","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1073\/pnas.1218667110","volume":"110","author":"F Bock","year":"2013","unstructured":"Bock F, Shahzad K, Wang H, et al. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A. 2013;110:648\u201353.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"29_CR35","doi-asserted-by":"crossref","first-page":"C464","DOI":"10.1152\/ajpcell.00563.2009","volume":"299","author":"Y Abe","year":"2010","unstructured":"Abe Y, Sakairi T, Kajiyama H, et al. Bioenergetic characterization of mouse podocytes. Am J Phys Cell Phys. 2010;299:C464\u201376.","journal-title":"Am J Phys Cell Phys"},{"key":"29_CR36","doi-asserted-by":"crossref","first-page":"18575","DOI":"10.1038\/srep18575","volume":"5","author":"S Ozawa","year":"2015","unstructured":"Ozawa S, Ueda S, Imamura H, et al. Glycolysis, but not Mitochondria, responsible for intracellular ATP distribution in cortical area of podocytes. Sci Rep. 2015;5:18575.","journal-title":"Sci Rep"},{"key":"29_CR37","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1172\/JCI37978","volume":"119","author":"PT Brinkkoetter","year":"2009","unstructured":"Brinkkoetter PT, Olivier P, Wu JS, et al. Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells. J Clin Invest. 2009;119:3089\u2013101.","journal-title":"J Clin Invest"},{"key":"29_CR38","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.4161\/cc.9.9.11471","volume":"9","author":"PT Brinkkoetter","year":"2010","unstructured":"Brinkkoetter PT, Pippin JW, Shankland SJ. Cyclin I-Cdk5 governs survival in post-mitotic cells. Cell Cycle Georget Tex. 2010;9:1729\u201331.","journal-title":"Cell Cycle Georget Tex"},{"key":"29_CR39","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/ki.2009.548","volume":"77","author":"PT Brinkkoetter","year":"2010","unstructured":"Brinkkoetter PT, Wu JS, Ohse T, et al. p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo. Kidney Int. 2010;77:690\u20139.","journal-title":"Kidney Int"},{"key":"29_CR40","first-page":"F1161","volume":"302","author":"Y Taniguchi","year":"2012","unstructured":"Taniguchi Y, Pippin JW, Hagmann H, et al. Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes. Am J Phys Renal Phys. 2012;302:F1161\u201371.","journal-title":"Am J Phys Renal Phys"},{"key":"29_CR41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.emboj.7601972","volume":"27","author":"T Tatsuta","year":"2008","unstructured":"Tatsuta T, Langer T. Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J. 2008;27:306\u201314.","journal-title":"EMBO J"},{"key":"29_CR42","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M503062200","volume":"280","author":"H Chen","year":"2005","unstructured":"Chen H, Chomyn A, Chan DC. Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem. 2005;280:26185\u201392.","journal-title":"J Biol Chem"},{"key":"29_CR43","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1242\/jcs.159186","volume":"129","author":"T MacVicar","year":"2016","unstructured":"MacVicar T, Langer T. OPA1 processing in cell death and disease \u2013 the long and short of it. J Cell Sci. 2016;129:2297\u2013306.","journal-title":"J Cell Sci"},{"key":"29_CR44","doi-asserted-by":"crossref","first-page":"37972","DOI":"10.1074\/jbc.M606059200","volume":"281","author":"S Duvezin-Caubet","year":"2006","unstructured":"Duvezin-Caubet S, Jagasia R, Wagener J, et al. Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J Biol Chem. 2006;281:37972\u20139.","journal-title":"J Biol Chem"},{"key":"29_CR45","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1101\/gad.460708","volume":"22","author":"C Merkwirth","year":"2008","unstructured":"Merkwirth C, Dargazanli S, Tatsuta T, et al. Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev. 2008;22:476\u201388.","journal-title":"Genes Dev"},{"key":"29_CR46","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1128\/MCB.18.7.4043","volume":"18","author":"KH Berger","year":"1998","unstructured":"Berger KH, Yaffe MP. Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:4043\u201352.","journal-title":"Mol Cell Biol"},{"key":"29_CR47","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1091\/mbc.E04-09-0807","volume":"16","author":"T Tatsuta","year":"2005","unstructured":"Tatsuta T, Model K, Langer T. Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell. 2005;16:248\u201359.","journal-title":"Mol Biol Cell"},{"key":"29_CR48","doi-asserted-by":"crossref","unstructured":"Ising C, Koehler S, Br\u00e4hler S, et al. Inhibition of insulin\/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 2015;7:275\u201387.","DOI":"10.15252\/emmm.201404916"},{"key":"29_CR49","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1681\/ASN.2005050494","volume":"16","author":"L Barisoni","year":"2005","unstructured":"Barisoni L, Madaio MP, Eraso M, et al. The kd\/kd mouse is a model of collapsing glomerulopathy. J Am Soc Nephrol JASN. 2005;16:2847\u201351.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR50","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1046\/j.1523-1755.2001.0590041236.x","volume":"59","author":"O Hotta","year":"2001","unstructured":"Hotta O, Inoue CN, Miyabayashi S, et al. Clinical and pathologic features of focal segmental glomerulosclerosis with mitochondrial tRNALeu(UUR) gene mutation. Kidney Int. 2001;59:1236\u201343.","journal-title":"Kidney Int"},{"key":"29_CR51","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s10024-005-0058-z","volume":"8","author":"S G\u00fc\u00e7er","year":"2005","unstructured":"G\u00fc\u00e7er S, Talim B, A\u015fan E, et al. Focal segmental glomerulosclerosis associated with mitochondrial cytopathy: report of two cases with special emphasis on podocytes. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc. 2005;8:710\u20137.","journal-title":"Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc"},{"key":"29_CR52","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1681\/ASN.V1261164","volume":"12","author":"GS Markowitz","year":"2001","unstructured":"Markowitz GS, Appel GB, Fine PL, et al. Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate. J Am Soc Nephrol JASN. 2001;12:1164\u201372.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR53","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1681\/ASN.2013111202","volume":"26","author":"T Kawakami","year":"2015","unstructured":"Kawakami T, Gomez IG, Ren S, et al. Deficient autophagy results in mitochondrial dysfunction and FSGS. J Am Soc Nephrol JASN. 2015;26:1040\u201352.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR54","doi-asserted-by":"crossref","first-page":"e34315","DOI":"10.1371\/journal.pone.0034315","volume":"7","author":"D Liu","year":"2012","unstructured":"Liu D, Lin Y, Kang T, et al. Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. PLoS One. 2012;7:e34315.","journal-title":"PLoS One"},{"key":"29_CR55","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1083\/jcb.200706072","volume":"180","author":"M Schleicher","year":"2008","unstructured":"Schleicher M, Shepherd BR, Suarez Y, et al. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol. 2008;180:101\u201312.","journal-title":"J Cell Biol"},{"key":"29_CR56","doi-asserted-by":"crossref","first-page":"e31231","DOI":"10.1371\/journal.pone.0031231","volume":"7","author":"AS Kathiria","year":"2012","unstructured":"Kathiria AS, Butcher LD, Feagins LA, et al. Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PLoS One. 2012;7:e31231.","journal-title":"PLoS One"},{"key":"29_CR57","doi-asserted-by":"crossref","first-page":"e1003021","DOI":"10.1371\/journal.pgen.1003021","volume":"8","author":"C Merkwirth","year":"2012","unstructured":"Merkwirth C, Martinelli P, Korwitz A, et al. Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS Genet. 2012;8:e1003021.","journal-title":"PLoS Genet"},{"key":"29_CR58","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/stem.695","volume":"29","author":"OR Baris","year":"2011","unstructured":"Baris OR, Klose A, Kloepper JE, et al. The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells Dayt Ohio. 2011;29:1459\u201368.","journal-title":"Stem Cells Dayt Ohio"},{"key":"29_CR59","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature08466","volume":"461","author":"M Artal-Sanz","year":"2009","unstructured":"Artal-Sanz M, Tavernarakis N. Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature. 2009;461:793\u20137.","journal-title":"Nature"},{"key":"29_CR60","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.2337\/diabetes.54.11.3095","volume":"54","author":"RJM Coward","year":"2005","unstructured":"Coward RJM, Welsh GI, Yang J, et al. The human glomerular podocyte is a novel target for insulin action. Diabetes. 2005;54:3095\u2013102.","journal-title":"Diabetes"},{"key":"29_CR61","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1523-1755.2005.00208.x","volume":"67","author":"DJ Bridgewater","year":"2005","unstructured":"Bridgewater DJ, Ho J, Sauro V, et al. Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway. Kidney Int. 2005;67:1308\u201314.","journal-title":"Kidney Int"},{"key":"29_CR62","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1172\/JCI44774","volume":"121","author":"M G\u00f6del","year":"2011","unstructured":"G\u00f6del M, Hartleben B, Herbach N, et al. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest. 2011;121:2197\u2013209.","journal-title":"J Clin Invest"},{"key":"29_CR63","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1172\/JCI44771","volume":"121","author":"K Inoki","year":"2011","unstructured":"Inoki K, Mori H, Wang J, et al. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest. 2011;121:2181\u201396.","journal-title":"J Clin Invest"},{"key":"29_CR64","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/labinvest.2011.135","volume":"91","author":"N Ito","year":"2011","unstructured":"Ito N, Nishibori Y, Ito Y, et al. mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Lab Invest J Tech Methods Pathol. 2011;91:1584\u201395.","journal-title":"Lab Invest J Tech Methods Pathol"},{"key":"29_CR65","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000020648","volume":"8","author":"C Daniel","year":"2000","unstructured":"Daniel C, Ziswiler R, Frey B, et al. Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivative. Exp Nephrol. 2000;8:52\u201362.","journal-title":"Exp Nephrol"},{"key":"29_CR66","first-page":"F418","volume":"296","author":"B Vollenbr\u00f6ker","year":"2009","unstructured":"Vollenbr\u00f6ker B, George B, Wolfgart M, et al. mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes. Am J Phys Renal Phys. 2009;296:F418\u201326.","journal-title":"Am J Phys Renal Phys"},{"key":"29_CR67","first-page":"F1152","volume":"300","author":"B George","year":"2011","unstructured":"George B, Vollenbr\u00f6ker B, Saleem MA, et al. GSK3\u03b2 inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility. Am J Phys Renal Phys. 2011;300:F1152\u201362.","journal-title":"Am J Phys Renal Phys"},{"key":"29_CR68","doi-asserted-by":"crossref","first-page":"47853","DOI":"10.1074\/jbc.M305171200","volume":"278","author":"G Fusaro","year":"2003","unstructured":"Fusaro G, Dasgupta P, Rastogi S, et al. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J Biol Chem. 2003;278:47853\u201361.","journal-title":"J Biol Chem"},{"key":"29_CR69","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.2337\/db13-0152","volume":"62","author":"S Supale","year":"2013","unstructured":"Supale S, Thorel F, Merkwirth C, et al. Loss of prohibitin induces mitochondrial damages altering \u03b2-cell function and survival and is responsible for gradual diabetes development. Diabetes. 2013;62:3488\u201399.","journal-title":"Diabetes"},{"key":"29_CR70","doi-asserted-by":"crossref","first-page":"35848","DOI":"10.1074\/jbc.M001327200","volume":"275","author":"R Delage-Mourroux","year":"2000","unstructured":"Delage-Mourroux R, Martini PG, Choi I, et al. Analysis of estrogen receptor interaction with a repressor of estrogen receptor activity (REA) and the regulation of estrogen receptor transcriptional activity by REA. J Biol Chem. 2000;275:35848\u201356.","journal-title":"J Biol Chem"},{"key":"29_CR71","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1038\/sj.onc.1205944","volume":"21","author":"S Wang","year":"2002","unstructured":"Wang S, Fusaro G, Padmanabhan J, et al. Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene. 2002;21:8388\u201396.","journal-title":"Oncogene"},{"key":"29_CR72","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1128\/MCB.25.5.1989-1999.2005","volume":"25","author":"S-E Park","year":"2005","unstructured":"Park S-E, Xu J, Frolova A, et al. Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo. Mol Cell Biol. 2005;25:1989\u201399.","journal-title":"Mol Cell Biol"},{"key":"29_CR73","doi-asserted-by":"crossref","first-page":"24834","DOI":"10.1074\/jbc.M312300200","volume":"279","author":"V Kurtev","year":"2004","unstructured":"Kurtev V, Margueron R, Kroboth K, et al. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004;279:24834\u201343.","journal-title":"J Biol Chem"},{"key":"29_CR74","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/onc.2012.86","volume":"32","author":"C-F Chiu","year":"2013","unstructured":"Chiu C-F, Ho M-Y, Peng J-M, et al. Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane. Oncogene. 2013;32:777\u201387.","journal-title":"Oncogene"},{"key":"29_CR75","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.bbrc.2009.10.101","volume":"390","author":"SR Ande","year":"2009","unstructured":"Ande SR, Mishra S. Prohibitin interacts with phosphatidylinositol 3,4,5-triphosphate (PIP3) and modulates insulin signaling. Biochem Biophys Res Commun. 2009;390:1023\u20138.","journal-title":"Biochem Biophys Res Commun"},{"key":"29_CR76","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.ajpath.2015.12.018","volume":"186","author":"C Ising","year":"2016","unstructured":"Ising C, Bharill P, Brinkkoetter S, et al. Prohibitin-2 depletion unravels extra-mitochondrial functions at the kidney filtration barrier. Am J Pathol. 2016;186:1128\u201339.","journal-title":"Am J Pathol"},{"key":"29_CR77","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/74166","volume":"24","author":"N Boute","year":"2000","unstructured":"Boute N, Gribouval O, Roselli S, et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet. 2000;24:349\u201354.","journal-title":"Nat Genet"},{"key":"29_CR78","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1126\/science.286.5438.312","volume":"286","author":"NY Shih","year":"1999","unstructured":"Shih NY, Li J, Karpitskii V, et al. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science. 1999;286:312\u20135.","journal-title":"Science"},{"key":"29_CR79","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1681\/ASN.2008010059","volume":"19","author":"A Philippe","year":"2008","unstructured":"Philippe A, Nevo F, Esquivel EL, et al. Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome. J Am Soc Nephrol JASN. 2008;19:1871\u20138.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR80","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1106215","volume":"308","author":"MP Winn","year":"2005","unstructured":"Winn MP, Conlon PJ, Lynn KL, et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science. 2005;308:1801\u20134.","journal-title":"Science"},{"key":"29_CR81","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1681\/ASN.2008070694","volume":"20","author":"B Schermer","year":"2009","unstructured":"Schermer B, Benzing T. Lipid-protein interactions along the slit diaphragm of podocytes. J Am Soc Nephrol JASN. 2009;20:473\u20138.","journal-title":"J Am Soc Nephrol JASN"},{"key":"29_CR82","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/MNH.0b013e3283471a22","volume":"20","author":"R-U M\u00fcller","year":"2011","unstructured":"M\u00fcller R-U, Zank S, Fabretti F, et al. Caenorhabditis elegans, a model organism for kidney research: from cilia to mechanosensation and longevity. Curr Opin Nephrol Hypertens. 2011;20:400\u20138.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"29_CR83","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nature00891","volume":"418","author":"Y Zhang","year":"2002","unstructured":"Zhang Y, Ma C, Delohery T, et al. Identification of genes expressed in C elegans touch receptor neurons. Nature. 2002;418:331\u20135.","journal-title":"Nature"},{"key":"29_CR84","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cub.2004.10.030","volume":"14","author":"S Zhang","year":"2004","unstructured":"Zhang S, Arnadottir J, Keller C, et al. MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain. Curr Biol CB. 2004;14:1888\u201396.","journal-title":"Curr Biol CB"},{"key":"29_CR85","first-page":"1372","volume":"2009","author":"SR Ande","year":"1793","unstructured":"Ande SR, Gu Y, Nyomba BLG, et al. Insulin induced phosphorylation of prohibitin at tyrosine 114 recruits Shp1. Biochim Biophys Acta. 1793;2009:1372\u20138.","journal-title":"Biochim Biophys Acta"},{"key":"29_CR86","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.bbabio.2015.06.003","volume":"1847","author":"AB Louren\u00e7o","year":"2015","unstructured":"Louren\u00e7o AB, Mu\u00f1oz-Jim\u00e9nez C, Venegas-Caler\u00f3n M, et al. Analysis of the effect of the mitochondrial prohibitin complex, a context-dependent modulator of longevity, on the C. elegans metabolome. Biochim Biophys Acta. 2015;1847:1457\u201368.","journal-title":"Biochim Biophys Acta"},{"key":"29_CR87","doi-asserted-by":"crossref","first-page":"aad0116","DOI":"10.1126\/science.aad0116","volume":"350","author":"T Wai","year":"2015","unstructured":"Wai T, Garc\u00eda-Prieto J, Baker MJ, et al. Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science. 2015;350:aad0116.","journal-title":"Science"}],"container-title":["Advances in Experimental Medicine and Biology","Mitochondrial Dynamics in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-55330-6_29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T22:35:54Z","timestamp":1659047754000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-55330-6_29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319553290","9783319553306"],"references-count":87,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-55330-6_29","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}