{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:37:14Z","timestamp":1778528234329,"version":"3.51.4"},"publisher-location":"Cham","reference-count":46,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319560168","type":"print"},{"value":"9783319560175","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-56017-5_5","type":"book-chapter","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:25:11Z","timestamp":1510129511000},"page":"55-60","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Ultraviolet Light on Vitiligo"],"prefix":"10.1007","author":[{"given":"Rasnik K.","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"5_CR1","doi-asserted-by":"publisher","unstructured":"Ezzedine K, Silverberg N (2016) A practical approach to the diagnosis and treatment of vitiligo in children. Pediatrics. doi: 10.1542\/peds.2015-4126","DOI":"10.1542\/peds.2015-4126"},{"key":"5_CR2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jaad.2015.05.038","volume":"73","author":"EW Mu","year":"2015","unstructured":"Mu EW, Cohen BE, Orlow SJ (2015) Early-onset childhood vitiligo is associated with a more extensive and progressive course. J Am Acad Dermatol 73:467\u2013470","journal-title":"J Am Acad Dermatol"},{"key":"5_CR3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1046\/j.1365-4362.2000.00880.x","volume":"39","author":"AM Boisseau-Garsaud","year":"2000","unstructured":"Boisseau-Garsaud AM, Garsaud P, Cal\u00e8s-Quist D, H\u00e9l\u00e9non R, Qu\u00e9n\u00e9herv\u00e9 C, Claire RC (2000) Epidemiology of vitiligo in the French West Indies (Isle of Martinique). Int J Dermatol 39:18\u201320","journal-title":"Int J Dermatol"},{"key":"5_CR4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archderm.1977.01640010049006","volume":"113","author":"J Howitz","year":"1977","unstructured":"Howitz J, Brodthagen H, Schwartz M, Thomsen K (1977) Prevalence of vitiligo. Epidemiological survey on the Isle of Bornholm, Denmark. Arch Dermatol 113:47\u201352","journal-title":"Arch Dermatol"},{"key":"5_CR5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jaad.2009.03.022","volume":"61","author":"MW Linthorst Homan","year":"2009","unstructured":"Linthorst Homan MW, Spuls PI, de Korte J, Bos JD, Sprangers MA, van der Veen JPW (2009) The burden of vitiligo: patient characteristics associated with quality of life. J Am Acad Dermatol 61:411\u2013420","journal-title":"J Am Acad Dermatol"},{"key":"5_CR6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.2307\/2137152","volume":"32","author":"JR Porter","year":"1991","unstructured":"Porter JR, Beuf AH (1991) Racial variation in reaction to physical stigma: a study of degree of disturbance by vitiligo among black and white patients. J Health Soc Behav 32:192\u2013204","journal-title":"J Health Soc Behav"},{"key":"5_CR7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/pcmr.12186","volume":"27","author":"K Ezzedine","year":"2014","unstructured":"Ezzedine K, Le Thuaut A, Jouary T, Ballanger F, Taieb A, Bastuji-Garin S (2014) Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes. Pigment Cell Melanoma Res 27:134\u2013139","journal-title":"Pigment Cell Melanoma Res"},{"key":"5_CR8","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1755-148X.2012.00997.x","volume":"25","author":"K Ezzedine","year":"2012","unstructured":"Ezzedine K, Lim HW, Suzuki T et al (2012) Revised classification\/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res 25:E1\u201313","journal-title":"Pigment Cell Melanoma Res"},{"key":"5_CR9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jaad.2009.06.081","volume":"62","author":"J Mazereeuw-Hautier","year":"2010","unstructured":"Mazereeuw-Hautier J, Bezio S, Mahe E et al (2010) Segmental and nonsegmental childhood vitiligo has distinct clinical characteristics: a prospective observational study. J Am Acad Dermatol 62:945\u2013949","journal-title":"J Am Acad Dermatol"},{"key":"5_CR10","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1056\/NEJMoa0908547","volume":"362","author":"Y Jin","year":"2010","unstructured":"Jin Y, Birlea SA, Fain PR et al (2010) Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med 362:1686\u20131697","journal-title":"N Engl J Med"},{"key":"5_CR11","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/jid.2011.12","volume":"131","author":"Y Jin","year":"2011","unstructured":"Jin Y, Birlea SA, Fain PR et al (2011) Genome-wide analysis identifies a quantitative trait locus in the mhc class ii region associated with generalized vitiligo age of onset. J Invest Dermatol 131:1308\u20131312","journal-title":"J Invest Dermatol"},{"key":"5_CR12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ng.603","volume":"42","author":"C Quan","year":"2010","unstructured":"Quan C, Ren Y-Q, Xiang L-H et al (2010) Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nat Genet 42:614\u2013618","journal-title":"Nat Genet"},{"key":"5_CR13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3346\/jkms.2013.28.5.775","volume":"28","author":"KA Cheong","year":"2013","unstructured":"Cheong KA, Kim N-H, Noh M, Lee A-Y (2013) Three new single nucleotide polymorphisms identified by a genome-wide association study in korean patients with vitiligo. J Korean Med Sci 28:775","journal-title":"J Korean Med Sci"},{"key":"5_CR14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1034\/j.1600-0749.2003.00032.x","volume":"16","author":"A Alkhateeb","year":"2003","unstructured":"Alkhateeb A, Fain PR, Thody A, Bennett DC, Spritz RA (2003) Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res 16:208\u2013214","journal-title":"Pigment Cell Res"},{"key":"5_CR15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0002-9440(10)63294-4","volume":"165","author":"EMJ Peters","year":"2004","unstructured":"Peters EMJ, Handjiski B, Kuhlmei A, Hagen E, Bielas H, Braun A, Klapp BF, Paus R, Arck PC (2004) Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor. Am J Pathol 165:259\u2013271","journal-title":"Am J Pathol"},{"key":"5_CR16","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1046\/j.1523-1747.2001.00000.x","volume":"117","author":"DA Norris","year":"2001","unstructured":"Norris DA (2001) In this issue. J Invest Dermatol 117:1025\u20131026","journal-title":"J Invest Dermatol"},{"key":"5_CR17","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00403-009-0964-4","volume":"301","author":"R Khan","year":"2009","unstructured":"Khan R, Satyam A, Gupta S, Sharma VK, Sharma A (2009) Circulatory levels of antioxidants and lipid peroxidation in Indian patients with generalized and localized vitiligo. Arch Dermatol Res 301:731\u2013737","journal-title":"Arch Dermatol Res"},{"key":"5_CR18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/cei.12146","volume":"174","author":"S You","year":"2013","unstructured":"You S, Cho Y-H, Byun J-S, Shin E-C (2013) Melanocyte-specific CD8 + T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo. Clin Exp Immunol 174:38\u201344","journal-title":"Clin Exp Immunol"},{"key":"5_CR19","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1365-2133.2009.09217.x","volume":"161","author":"ZA Taher","year":"2009","unstructured":"Taher ZA, Lauzon G, Maguiness S, Dytoc MT (2009) Analysis of interleukin-10 levels in lesions of vitiligo following treatment with topical tacrolimus. Br J Dermatol 161:654\u2013659","journal-title":"Br J Dermatol"},{"key":"5_CR20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.autrev.2016.01.004","volume":"15","author":"RK Singh","year":"2016","unstructured":"Singh RK, Lee KM, Vujkovic-Cvijin I et al (2016) The role of IL-17 in vitiligo: a review. Autoimmun Rev 15:397\u2013404","journal-title":"Autoimmun Rev"},{"key":"5_CR21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jaad.2015.08.063","volume":"74","author":"L Gill","year":"2016","unstructured":"Gill L, Zarbo A, Isedeh P, Jacobsen G, Lim HW, Hamzavi I (2016) Comorbid autoimmune diseases in patients with vitiligo: a cross-sectional study. J Am Acad Dermatol 74:295\u2013302","journal-title":"J Am Acad Dermatol"},{"key":"5_CR22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s13555-016-0129-2","volume":"6","author":"RK Singh","year":"2016","unstructured":"Singh RK, Lee KM, Jose MV, Nakamura M, Ucmak D, Farahnik B, Abrouk M, Zhu TH, Bhutani T, Liao W (2016) The patient\u2019s guide to psoriasis treatment. Part 1: UVB phototherapy. Dermatol Ther (Heidelb) 6:307\u2013313","journal-title":"Dermatol Ther (Heidelb)"},{"key":"5_CR23","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1046\/j.1365-2133.1999.02898.x","volume":"140","author":"MS Duthie","year":"1999","unstructured":"Duthie MS, Kimber I, Norval M (1999) The effects of ultraviolet radiation on the human immune system. Br J Dermatol 140:995\u20131009","journal-title":"Br J Dermatol"},{"key":"5_CR24","first-page":"48","volume":"79","author":"G Sethi","year":"2004","unstructured":"Sethi G, Sodhi A (2004) Role of p38 mitogen-activated protein kinase and caspases in UV-B-induced apoptosis of murine peritoneal macrophages. Photochem Photobiol 79:48\u201354","journal-title":"Photochem Photobiol"},{"key":"5_CR25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/1523-1747.ep12580300","volume":"89","author":"H Okamoto","year":"1987","unstructured":"Okamoto H, Horio T, Maeda M (1987) Alteration of lymphocyte functions by 8-methoxypsoralen and long-wave ultraviolet radiation. II. The effect of in vivo PUVA on IL-2 production. J Invest Dermatol 89:24\u201326","journal-title":"J Invest Dermatol"},{"key":"5_CR26","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.4049\/jimmunol.133.6.3128","volume":"133","author":"ML Weitzen","year":"1984","unstructured":"Weitzen ML, Bonavida B (1984) Mechanism of inhibition of human natural killer activity by ultraviolet radiation. J Immunol 133:3128\u20133132","journal-title":"J Immunol"},{"key":"5_CR27","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/1523-1747.ep12480997","volume":"97","author":"J Cui","year":"1991","unstructured":"Cui J, Shen LY, Wang GC (1991) Role of hair follicles in the repigmentation of vitiligo. J Invest Dermatol 97:410\u2013416","journal-title":"J Invest Dermatol"},{"key":"5_CR28","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.0906-6705.2004.00221.x","volume":"13","author":"C-S Wu","year":"2004","unstructured":"Wu C-S, Yu C-L, Wu C-S, Lan C-CE YH-S (2004) Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes. Exp Dermatol 13:755\u2013763","journal-title":"Exp Dermatol"},{"key":"5_CR29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jaad.2008.07.053","volume":"60","author":"E Nicolaidou","year":"2009","unstructured":"Nicolaidou E, Antoniou C, Stratigos A, Katsambas AD (2009) Narrowband ultraviolet B phototherapy and 308-nm excimer laser in the treatment of vitiligo: a review. J Am Acad Dermatol 60:470\u2013477","journal-title":"J Am Acad Dermatol"},{"key":"5_CR30","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jaad.2008.06.023","volume":"59","author":"ME Whitton","year":"2008","unstructured":"Whitton ME, Ashcroft DM, Gonz\u00e1lez U (2008) Therapeutic interventions for vitiligo. J Am Acad Dermatol 59:713\u2013717","journal-title":"J Am Acad Dermatol"},{"key":"5_CR31","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1346-8138.2005.tb00847.x","volume":"32","author":"G-Y Chen","year":"2005","unstructured":"Chen G-Y, Hsu MM-L, Tai H-K, Chou T-C, Tseng C-L, Chang H-Y, Lan C-CE, Sheu H-M (2005) Narrow-band UVB treatment of vitiligo in Chinese. J Dermatol 32:793\u2013800","journal-title":"J Dermatol"},{"key":"5_CR32","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2230.2005.01837.x","volume":"30","author":"AJ Kanwar","year":"2005","unstructured":"Kanwar AJ, Dogra S (2005) Narrow-band UVB for the treatment of generalized vitiligo in children. Clin Exp Dermatol 30:332\u2013336","journal-title":"Clin Exp Dermatol"},{"key":"5_CR33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-4632.2004.02329.x","volume":"44","author":"AJ Kanwar","year":"2005","unstructured":"Kanwar AJ, Dogra S, Parsad D, Kumar B (2005) Narrow-band UVB for the treatment of vitiligo: an emerging effective and well-tolerated therapy. Int J Dermatol 44:57\u201360","journal-title":"Int J Dermatol"},{"key":"5_CR34","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jaad.2006.09.004","volume":"56","author":"E Nicolaidou","year":"2007","unstructured":"Nicolaidou E, Antoniou C, Stratigos AJ, Stefanaki C, Katsambas AD (2007) Efficacy, predictors of response, and long-term follow-up in patients with vitiligo treated with narrowband UVB phototherapy. J Am Acad Dermatol 56:274\u2013278","journal-title":"J Am Acad Dermatol"},{"key":"5_CR35","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4103\/0019-5154.57604","volume":"54","author":"R Falabella","year":"2009","unstructured":"Falabella R (2009) Vitiligo and the melanocyte reservoir. Indian J Dermatol 54:313","journal-title":"Indian J Dermatol"},{"key":"5_CR36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1468-3083.2006.01413.x","volume":"20","author":"D Parsad","year":"2006","unstructured":"Parsad D, Kanwar AJ, Kumar B (2006) Psoralen-ultraviolet A vs. narrow-band ultraviolet B phototherapy for the treatment of vitiligo. J Eur Acad Dermatol Venereol 20:175\u2013177","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5_CR37","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1468-3083.2007.02283.x","volume":"21","author":"A Bhatnagar","year":"2007","unstructured":"Bhatnagar A, Kanwar AJ, Parsad D, De D (2007) Comparison of systemic PUVA and NB-UVB in the treatment of vitiligo: an open prospective study. J Eur Acad Dermatol Venereol 21:638\u2013642","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5_CR38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1600-0781.2006.00189.x","volume":"22","author":"M Mofty El","year":"2006","unstructured":"El Mofty M, Mostafa W, Esmat S, Youssef R, Azzam O, Hunter N, El Hanafi G, Fawzi M (2006) Narrow band Ultraviolet B 311 nm in the treatment of vitiligo: two right-left comparison studies. Photodermatol Photoimmunol Photomed 22:6\u201311","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"5_CR39","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archderm.143.5.578","volume":"143","author":"SS Yones","year":"2007","unstructured":"Yones SS, Palmer RA, Garibaldinos TM, Hawk JLM (2007) Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs Narrowband-UV-B therapy. Arch Dermatol 143:578\u2013584","journal-title":"Arch Dermatol"},{"key":"5_CR40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4103\/0378-6323.144143","volume":"80","author":"S Prabhu","year":"2014","unstructured":"Prabhu S, Shenoi S (2014) Photochemotherapy (PUVA) in psoriasis and vitiligo. Indian J Dermatol Venereol Leprol 80:497","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"5_CR41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2230.2006.02309.x","volume":"32","author":"CP Choi","year":"2007","unstructured":"Choi CP, Kim YI, Lee JW, Lee MH (2007) The effect of narrowband ultraviolet B on the expression of matrix metalloproteinase-1, transforming growth factor-?1 and type I collagen in human skin fibroblasts. Clin Exp Dermatol 32:180\u2013185","journal-title":"Clin Exp Dermatol"},{"key":"5_CR42","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jaad.2014.07.050","volume":"71","author":"A Paradisi","year":"2014","unstructured":"Paradisi A, Tabolli S, Didona B, Sobrino L, Russo N, Abeni D (2014) Markedly reduced incidence of melanoma and nonmelanoma skin cancer in a nonconcurrent cohort of 10,040 patients with vitiligo. J Am Acad Dermatol 71:1110\u20131116","journal-title":"J Am Acad Dermatol"},{"key":"5_CR43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/bjd.12111","volume":"168","author":"HE Teulings","year":"2013","unstructured":"Teulings HE, Overkamp M, Ceylan E, Nieuweboer-Krobotova L, Bos JD, Nijsten T, Wolkerstorfer AW, Luiten RM, van der Veen JPW (2013) Decreased risk of melanoma and nonmelanoma skin cancer in patients with vitiligo: a survey among 1307 patients and their partners. Br J Dermatol 168:162\u2013171","journal-title":"Br J Dermatol"},{"key":"5_CR44","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1034\/j.1600-0625.2003.00084.x","volume":"12","author":"KU Schallreuter","year":"2003","unstructured":"Schallreuter KU, Behrens-Williams S, Khaliq TP, Picksley SM, Peters EMJ, Marles LK, Westerhof W, Miehe B, Fangh\u00e4nel J (2003) Increased epidermal functioning wild-type p53 expression in vitiligo. Exp Dermatol 12:268\u2013277","journal-title":"Exp Dermatol"},{"key":"5_CR45","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/archderm.141.3.305","volume":"141","author":"C Querfeld","year":"2005","unstructured":"Querfeld C (2005) Long-term follow-up of patients with early-stage cutaneous T-Cell Lymphoma who achieved complete remission with psoralen plus UV-a monotherapy. Arch Dermatol 141:305\u2013311","journal-title":"Arch Dermatol"},{"key":"5_CR46","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/09546634.2015.1133882","volume":"27","author":"A Maiorino","year":"2016","unstructured":"Maiorino A, De Simone C, Perino F, Caldarola G, Peris K (2016) Melanoma and non-melanoma skin cancer in psoriatic patients treated with high-dose phototherapy. J Dermatolog Treat 27:443\u2013447","journal-title":"J Dermatolog Treat"}],"container-title":["Advances in Experimental Medicine and Biology","Ultraviolet Light in Human Health, Diseases and Environment"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-56017-5_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:34:36Z","timestamp":1693197276000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-56017-5_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319560168","9783319560175"],"references-count":46,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-56017-5_5","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}