{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:45:14Z","timestamp":1773661514988,"version":"3.50.1"},"publisher-location":"Cham","reference-count":44,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319571911","type":"print"},{"value":"9783319571935","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-57193-5_10","type":"book-chapter","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T05:03:24Z","timestamp":1499058204000},"page":"281-293","source":"Crossref","is-referenced-by-count":6,"title":["Stroke: Basic and Clinical"],"prefix":"10.1007","author":[{"given":"Tarvinder P.","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean P.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"10_CR1","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1161\/CIR.0b013e31828124ad","volume":"127","author":"AS Go","year":"2013","unstructured":"Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB et al (2013) Heart disease and stroke statistics\u20142013 update. Circulation 127:e6\u2013e245","journal-title":"Circulation"},{"key":"10_CR2","doi-asserted-by":"crossref","unstructured":"Ovbiagele B, Goldstein LB, Higashida RT, Howard VJ, Johnston SC, Khavjou OA, et al. on behalf of the American Heart Association Advocacy Coordinating Committee and Stroke Council. Forecasting the future of stroke in the United States. Stroke 2013;44:2361\u201375.","DOI":"10.1161\/STR.0b013e31829734f2"},{"key":"10_CR3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/jcbfm.2014.41","volume":"34","author":"D Fernandez-Lopez","year":"2014","unstructured":"Fernandez-Lopez D, Natarajan N, Ashwal S, Vexler ZS (2014) Mechanisms of perinatal arterial ischemic stroke. J Cereb Blood Flow Metab 34:921\u2013932","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12975-012-0245-y","volume":"4","author":"X Zhao","year":"2013","unstructured":"Zhao X, Aronowski J (2013) Nrf2 to pre-condition the brain against injury caused by products of hemolysis after ICH. Transl Stroke Res 4:71\u201375","journal-title":"Transl Stroke Res"},{"key":"10_CR5","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/STROKEAHA.114.007564","volume":"46","author":"BCV Campbell","year":"2015","unstructured":"Campbell BCV, Meretoja A, Donnan GA, Davis SM (2015) Twenty-year history of the evolution of stroke thrombolysis with intravenous alteplase to reduce long-term disability. Stroke 46:2341\u20132346","journal-title":"Stroke"},{"key":"10_CR6","first-page":"75","volume":"10","author":"SN Chapman","year":"2014","unstructured":"Chapman SN, Mehndiratta P, Johansen MC, McMurry TL, Johnston KC, Southerland AM (2014) Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke. Vasc Health Risk Manag 10:75\u201387","journal-title":"Vasc Health Risk Manag"},{"key":"10_CR7","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1161\/STROKEAHA.115.008385","volume":"46","author":"EE Smith","year":"2015","unstructured":"Smith EE, Schwamm LH (2015) Endovascular clot retrieval therapy: implications for the organization of stroke systems of care in North America. Stroke 46:1462\u20131467","journal-title":"Stroke"},{"key":"10_CR8","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/jcbfm.2014.159","volume":"34","author":"G Trendelenburg","year":"2014","unstructured":"Trendelenburg G (2014) Molecular regulation of cell fate in cerebral ischemia. J Cereb Blood Flow Metab 34:1857\u20131867","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/jcbfm.2013.188","volume":"34","author":"J-C Baron","year":"2013","unstructured":"Baron J-C, Yamauchi H, Fujioka M, Endres M (2013) Selective neuronal loss in ischemic stroke and cerebrovascular disease. J Cereb Blood Flow Metab 34:2\u201318","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR10","first-page":"305","volume":"61","author":"JB Casals","year":"2011","unstructured":"Casals JB, Pieri NCG, Feitosa MLT, Ercolin ACM, Roballo KCS, Barreto RSN et al (2011) The use of animal models for stroke research. Comp Med 61:305\u2013313","journal-title":"Comp Med"},{"key":"10_CR11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nprot.2015.036","volume":"10","author":"L Zhang","year":"2015","unstructured":"Zhang L, Zhang RL, Jiang Q, Ding G, Chopp M, Zhang ZG (2015) Focal embolic cerebral ischemia in the rat. Nat Protoc 10:539\u2013547","journal-title":"Nat Protoc"},{"key":"10_CR12","unstructured":"English JD, Hetts SW, El-Ali A, Kolli P, Do L, Wilson MW et al (2014) A novel model of large vessel ischemic stroke in rabbits. J Neurointerv Surg:1\u20134"},{"key":"10_CR13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/jcbfm.2012.185","volume":"33","author":"M Balkaya","year":"2013","unstructured":"Balkaya M, Kr\u00f6ber JM, Rex A, Endres M (2013b) Assessing post-stroke behavior in mouse models of focal ischemia. J Cereb Blood Flow Metab 33:330\u2013338","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jneumeth.2012.12.021","volume":"213","author":"M Balkaya","year":"2013","unstructured":"Balkaya M, Kr\u00f6ber JM, Gertz K, Peruzzaro S, Endres M (2013a) Characterization of long-term functional outcome in a murine model of mild brain ischemia. J Neurosci Methods 213:179\u2013187","journal-title":"J Neurosci Methods"},{"key":"10_CR15","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/S0140-6736(12)60738-7","volume":"379","author":"JM Wardlaw","year":"2012","unstructured":"Wardlaw JM, Murray V, Berge E, del Zoppo G, Sandercock P, Lindley RL et al (2012) Recombinant tissue plasminogen activator for acute ischemic stroke: an updated systematic review and meta-analysis. Lancet 379:2364\u20132372","journal-title":"Lancet"},{"key":"10_CR16","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/jcbfm.2012.141","volume":"32","author":"RAM Haast","year":"2012","unstructured":"Haast RAM, Gustafson DR, Kiliaan AJ (2012) Sex differences in stroke. J Cereb Blood Flow Metab 32:2100\u20132107","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR17","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/jcbfm.2013.102","volume":"33","author":"CL Gibson","year":"2013","unstructured":"Gibson CL (2013) Cerebral ischemic stroke\u2014is gender important? J Cereb Blood Flow Metab 33:1355\u20131361","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/1545968312474119","volume":"27","author":"MP Kahle","year":"2013","unstructured":"Kahle MP, Bix GJ (2013) Neuronal restoration following ischemic stroke: influences, barriers, and therapeutic potential. Neurorehabil Neural Repair 27:469\u2013478","journal-title":"Neurorehabil Neural Repair"},{"key":"10_CR19","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1161\/STROKEAHA.110.599654","volume":"42","author":"O Lindvall","year":"2011","unstructured":"Lindvall O, Kokaia Z (2011) Stem cell research in stroke. Stroke 42:2369\u20132375","journal-title":"Stroke"},{"key":"10_CR20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrn2735","volume":"10","author":"TH Murphy","year":"2009","unstructured":"Murphy TH, Corbett D (2009) Plasticity during stroke recovery: from synapse to behavior. Nat Rev Neurosci 10:861\u2013872","journal-title":"Nat Rev Neurosci"},{"key":"10_CR21","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/jcbfm.2014.130","volume":"34","author":"MK Tobin","year":"2014","unstructured":"Tobin MK, Bonds JA, Minshall RD, Pelligrino DA, Testai FD, Lazarov O (2014) Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here. J Cereb Blood Flow Metab 34:1573\u20131584","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR22","doi-asserted-by":"crossref","unstructured":"Wang X, Mao XO, Xie L, Sun F, Greenberg DA, Jin K. Conditional depletion of neurogenesis inhibits long-term recovery after experimental stroke in mice. PLoS One 2012; 7: e38932.","DOI":"10.1371\/journal.pone.0038932"},{"key":"10_CR23","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1161\/STROKEAHA.115.007149","volume":"46","author":"S Savitz","year":"2015","unstructured":"Savitz S (2015) Developing cellular therapies for stroke. Stroke 46:2026\u20132031","journal-title":"Stroke"},{"key":"10_CR24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/ana.20741","volume":"59","author":"VE O\u2019Collins","year":"2006","unstructured":"O\u2019Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW (2006) 1,026 experimental treatments in acute stroke. Ann Neurol 59:467\u2013477","journal-title":"Ann Neurol"},{"key":"10_CR25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/brain\/awm183","volume":"131","author":"C Gibson","year":"2008","unstructured":"Gibson C, Gray L, Bath PMW, Murphy SP (2008) Progesterone for the treatment of experimental brain injury; a systematic review. Brain 131:318\u2013328","journal-title":"Brain"},{"key":"10_CR26","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/jcbfm.2014.218","volume":"35","author":"TJ England","year":"2015","unstructured":"England TJ, Hind WH, Rasid NA, O\u2019Sullivan SE (2015) Cannabinoids in experimental stroke: a systematic review and meta-analysis. J Cereb Blood Flow Metab 35:348\u2013358","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR27","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/STROKEAHA.107.498725","volume":"39","author":"NA Crossley","year":"2008","unstructured":"Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, Bath PMW et al (2008) Empirical evidence of bias in the design of experimental stroke studies. Stroke 39:929\u2013934","journal-title":"Stroke"},{"key":"10_CR28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tins.2007.06.009","volume":"30","author":"E Sena","year":"2007","unstructured":"Sena E, van der Worp HB, Howells D, Macleod M (2007) How can we improve the preclinical development of drugs for stroke? Trends Neurosci 30:433\u2013439","journal-title":"Trends Neurosci"},{"key":"10_CR29","doi-asserted-by":"crossref","first-page":"11753","DOI":"10.3390\/ijms130911753","volume":"13","author":"J Minnerup","year":"2012","unstructured":"Minnerup J, Sutherland BA, Buchan AM, Kleinschnitz C (2012) Neuroprotection for stroke: current status and future perspectives. Int J Mol Sci 13:11753\u201311772","journal-title":"Int J Mol Sci"},{"key":"10_CR30","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s12975-014-0349-7","volume":"5","author":"HA Seifert","year":"2014","unstructured":"Seifert HA, Pennypacker KR (2014) Molecular and cellular immune responses to ischemic brain injury. Transl Stroke Res 5:543\u2013553","journal-title":"Transl Stroke Res"},{"key":"10_CR31","doi-asserted-by":"crossref","unstructured":"Saver JL, Goyal M, Bonafe A, Diener H-C, Levy EI, Pereira VM. et al. for the SWIFT PRIME Investigators. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. NEJM 2015;372:2285\u201395.","DOI":"10.1056\/NEJMoa1415061"},{"key":"10_CR32","doi-asserted-by":"crossref","first-page":"7622","DOI":"10.1523\/JNEUROSCI.0369-12.2012","volume":"32","author":"B Chen","year":"2012","unstructured":"Chen B, Friedman B, Whitney MA, Winkle JA, Lei IF, Olson ES (2012) Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci 32:7622\u20137631","journal-title":"J Neurosci"},{"key":"10_CR33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1749-6632.2010.05761.x","volume":"1207","author":"GJ Zoppo del","year":"2010","unstructured":"del Zoppo GJ, Gorelick PB (2010) Innate inflammation as the common pathway of risk factors leading to TIAs and stroke. Ann N Y Acad Sci 1207:143\u2013148","journal-title":"Ann N Y Acad Sci"},{"key":"10_CR34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bbalip.2012.07.015","volume":"1831","author":"JW Choi","year":"2013","unstructured":"Choi JW, Chun J (2013) Lysophospholipids and their receptors in the central nervous system. Biochim Biophys Acta 1831:20\u201332","journal-title":"Biochim Biophys Acta"},{"key":"10_CR35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2217\/fnl.10.1","volume":"5","author":"JR Weinstein","year":"2010","unstructured":"Weinstein JR, Koerner IP, M\u00f6ller T (2010) Microglia in ischemic brain injury. Future Neurol 5:227\u2013246","journal-title":"Future Neurol"},{"key":"10_CR36","doi-asserted-by":"crossref","first-page":"15599","DOI":"10.1523\/JNEUROSCI.2544-15.2015","volume":"35","author":"MA Hamner","year":"2015","unstructured":"Hamner MA, Ye Z, Lee RV, Colman JR, Le T et al (2015) Ischemic preconditioning in white matter. J Neurosci 35:15599\u201315611","journal-title":"J Neurosci"},{"key":"10_CR37","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1523\/JNEUROSCI.0821-11.2011","volume":"31","author":"SL Stevens","year":"2011","unstructured":"Stevens SL, Leung PY, Vartanian KB, Gopalan B, Yang T, Simon RP et al (2011) Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury. J Neurosci 31:8456\u20138463","journal-title":"J Neurosci"},{"key":"10_CR38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12975-012-0223-4","volume":"4","author":"FR Bahjat","year":"2013","unstructured":"Bahjat FR, Gesuete R, Stenzel-Poore MP (2013) Steps to translate preconditioning from basic research to the clinic. Stroke Res 4:89\u2013103","journal-title":"Stroke Res"},{"key":"10_CR39","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/NEN.0000000000000068","volume":"73","author":"R Gesuete","year":"2014","unstructured":"Gesuete R, Kohama SG, Stenzel-Poore MP (2014) Toll-like receptors and ischemic brain injury. J Neuropathol Exp Neurol 73:378\u2013386","journal-title":"J Neuropathol Exp Neurol"},{"key":"10_CR40","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1152\/physiol.00014.2015","volume":"30","author":"TA Jones","year":"2015","unstructured":"Jones TA, Adkins DL (2015) Motor system reorganization after stroke. Physiology 30:358\u2013370","journal-title":"Physiology"},{"key":"10_CR41","first-page":"31","volume":"7","author":"D Kalladka","year":"2014","unstructured":"Kalladka D, Muir KW (2014) Brain repair: cell therapy in stroke. Stem Cells Cloning 7:31\u201344","journal-title":"Stem Cells Cloning"},{"key":"10_CR42","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fnins.2015.00458","volume":"9","author":"Q Marlier","year":"2015","unstructured":"Marlier Q, Verteneuil S, Vandenbosch R, Malgrange B (2015) Mechanisms and functional significance of stroke-induced neurogenesis. Front Neurosci 9:458","journal-title":"Front Neurosci"},{"key":"10_CR43","doi-asserted-by":"crossref","unstructured":"Boy S, Sauerbruch S, Kraemer M, Schormann T, Schlachetzki F et al. on behalf of the RAIS (Regeneration in Acute Ischemic Stroke) Study Group. Mobilisation of hematopoietic CD34+ precursor cells in patients with acute stroke is safe\u2014results of an open-labeled non randomized phase I\/II trial. PLoS One 2011;6(8):e23099.","DOI":"10.1371\/journal.pone.0023099"},{"key":"10_CR44","doi-asserted-by":"crossref","unstructured":"Prasad K, Sharma A, Garg A, Mohanty S, Bhatnagar S, Johri S, et al. on behalf of the InveST Study Group. Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial. Stroke 2014;45:3618\u201324.","DOI":"10.1161\/STROKEAHA.114.007028"}],"container-title":["Advances in Neurobiology","Neurodegenerative Diseases"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-57193-5_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T16:14:30Z","timestamp":1505319270000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-57193-5_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319571911","9783319571935"],"references-count":44,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-57193-5_10","relation":{},"ISSN":["2190-5215","2190-5223"],"issn-type":[{"value":"2190-5215","type":"print"},{"value":"2190-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}