{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:49:53Z","timestamp":1764557393819,"version":"3.40.3"},"publisher-location":"Cham","reference-count":16,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319577104"},{"type":"electronic","value":"9783319577111"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-57711-1_12","type":"book-chapter","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T08:39:35Z","timestamp":1492677575000},"page":"138-148","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Linking Alterations in Metabolic Fluxes with Shifts in Metabolite Levels by Means of Kinetic Modeling"],"prefix":"10.1007","author":[{"given":"Chiara","family":"Damiani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Di Filippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Pescini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"issue":"3","key":"12_CR1","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/msb.145122","volume":"10","author":"R Agren","year":"2014","unstructured":"Agren, R., Mardinoglu, A., Asplund, A., Kampf, C., Uhlen, M., Nielsen, J.: Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol. Syst. Biol. 10(3), 721 (2014)","journal-title":"Mol. Syst. Biol."},{"issue":"4","key":"12_CR2","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/bit.21813","volume":"100","author":"AB Canelas","year":"2008","unstructured":"Canelas, A.B., van Gulik, W.M., Heijnen, J.J.: Determination of the cytosolic free nad\/nadh ratio in saccharomyces cerevisiae under steady-state and highly dynamic conditions. Biotechnol. Bioeng. 100(4), 734\u2013743 (2008)","journal-title":"Biotechnol. Bioeng."},{"issue":"4","key":"12_CR3","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.3390\/metabo4041034","volume":"4","author":"P Cazzaniga","year":"2014","unstructured":"Cazzaniga, P., Damiani, C., Besozzi, D., Colombo, R., Nobile, M.S., Gaglio, D., Pescini, D., Molinari, S., Mauri, G., Alberghina, L., et al.: Computational strategies for a system-level understanding of metabolism. Metabolites 4(4), 1034\u20131087 (2014)","journal-title":"Metabolites"},{"key":"12_CR4","unstructured":"Colombo, R., Damiani, C., Mauri, G., Pescini, D.: Ensembles of parametrizations to investigate the crabtree phenotype by constraining mechanism-based simulations. In: Proceedings of CIBB 2016 (2016)"},{"key":"12_CR5","unstructured":"Cumbo, F., Nobile, M., Damiani, C., Colombo, R., Mauri, G., Cazzaniga, P.: Cosys: computational systems biology infrastructure. In: Proceedings of CIBB 2016 (2016)"},{"issue":"3","key":"12_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s11047-014-9439-4","volume":"13","author":"C Damiani","year":"2014","unstructured":"Damiani, C., Pescini, D., Colombo, R., Molinari, S., Alberghina, L., Vanoni, M., Mauri, G.: An ensemble evolutionary constraint-based approach to understand the emergence of metabolic phenotypes. Nat. Comput. 13(3), 321\u2013331 (2014)","journal-title":"Nat. Comput."},{"key":"12_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.compbiolchem.2016.03.002","volume":"62","author":"M Filippo Di","year":"2016","unstructured":"Di Filippo, M., Colombo, R., Damiani, C., Pescini, D., Gaglio, D., Vanoni, M., Alberghina, L., Mauri, G.: Zooming-in on cancer metabolic rewiring with tissue specific constraint-based models. Comput. Biol. Chem. 62, 60\u201369 (2016)","journal-title":"Comput. Biol. Chem."},{"issue":"5","key":"12_CR8","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cell.2008.08.026","volume":"134","author":"E Holmes","year":"2008","unstructured":"Holmes, E., Wilson, I.D., Nicholson, J.K.: Metabolic phenotyping in health and disease. Cell 134(5), 714\u2013717 (2008)","journal-title":"Cell"},{"issue":"6084","key":"12_CR9","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1126\/science.1218595","volume":"336","author":"M Jain","year":"2012","unstructured":"Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A.L., Kafri, R., Kirschner, M.W., Clish, C.B., Mootha, V.K.: Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336(6084), 1040\u20131044 (2012)","journal-title":"Science"},{"issue":"5","key":"12_CR10","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.cell.2015.05.019","volume":"161","author":"EJ OBrien","year":"2015","unstructured":"OBrien, E.J., Monk, J.M., Palsson, B.O.: Using genome-scale models to predict biological capabilities. Cell 161(5), 971\u2013987 (2015)","journal-title":"Cell"},{"key":"12_CR11","doi-asserted-by":"crossref","unstructured":"Petzold, L.: Automatic selection of methods for solving stiff and nonstiff systems of ordinary differential equations. SIAM J. Sci. Stat. Comput. 4(1), 136\u2013148 (1983). http:\/\/dx.doi.org\/10.1137\/0904010","DOI":"10.1137\/0904010"},{"issue":"8","key":"12_CR12","doi-asserted-by":"publisher","first-page":"e12383","DOI":"10.1371\/journal.pone.0012383","volume":"5","author":"O Resendis-Antonio","year":"2010","unstructured":"Resendis-Antonio, O., Checa, A., Encarnaci\u00f3n, S.: Modeling core metabolism in cancer cells: surveying the topology underlying the warburg effect. PloS one 5(8), e12383 (2010)","journal-title":"PloS one"},{"issue":"1","key":"12_CR13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/msb.2009.22","volume":"5","author":"T Shlomi","year":"2009","unstructured":"Shlomi, T., Cabili, M.N., Ruppin, E.: Predicting metabolic biomarkers of human inborn errors of metabolism. Mol. Syst. Biol. 5(1), 263 (2009)","journal-title":"Mol. Syst. Biol."},{"issue":"17","key":"12_CR14","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.1016\/j.febslet.2013.06.043","volume":"587","author":"K Smallbone","year":"2013","unstructured":"Smallbone, K., Messiha, H.L., Carroll, K.M., Winder, C.L., Malys, N., Dunn, W.B., Murabito, E., Swainston, N., Dada, J.O., Khan, F., et al.: A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. FEBS Lett. 587(17), 2832\u20132841 (2013)","journal-title":"FEBS Lett."},{"issue":"2","key":"12_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/(SICI)1097-0290(19970720)55:2<305::AID-BIT8>3.0.CO;2-M","volume":"55","author":"U Theobald","year":"1997","unstructured":"Theobald, U., Mailinger, W., Baltes, M., Rizzi, M., Reuss, M.: In vivo analysis of metabolic dynamics in saccharomyces cerevisiae: I. experimental observations. Biotechnol. Bioeng. 55(2), 305\u2013316 (1997)","journal-title":"Biotechnol. Bioeng."},{"issue":"2","key":"12_CR16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.mrgentox.2012.01.005","volume":"746","author":"C Wierling","year":"2012","unstructured":"Wierling, C., K\u00fchn, A., Hache, H., Daskalaki, A., Maschke-Dutz, E., Peycheva, S., Li, J., Herwig, R., Lehrach, H.: Prediction in the face of uncertainty: a Monte Carlo-based approach for systems biology of cancer treatment. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 746(2), 163\u2013170 (2012)","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."}],"container-title":["Communications in Computer and Information Science","Advances in Artificial Life, Evolutionary Computation, and Systems Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-57711-1_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T07:31:59Z","timestamp":1569051119000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-57711-1_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319577104","9783319577111"],"references-count":16,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-57711-1_12","relation":{},"ISSN":["1865-0929","1865-0937"],"issn-type":[{"type":"print","value":"1865-0929"},{"type":"electronic","value":"1865-0937"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"21 April 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"WIVACE","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Italian Workshop on Artificial Life and Evolutionary Computation","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Fisciano","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Italy","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2016","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"4 October 2016","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"6 October 2016","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"11","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"wivace2016","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/wivace.org\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}