{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T05:58:23Z","timestamp":1743141503897,"version":"3.40.3"},"publisher-location":"Cham","reference-count":38,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319595740"},{"type":"electronic","value":"9783319595757"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-59575-7_6","type":"book-chapter","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T09:14:49Z","timestamp":1496135689000},"page":"59-70","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Paired miRNA-mRNA Microarray Expression Data Using a Stepwise Multiple Linear Regression Model"],"prefix":"10.1007","author":[{"given":"Yiqian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehman","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Sacan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,31]]},"reference":[{"issue":"2","key":"6_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel, D.P.: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2), 281\u2013297 (2004)","journal-title":"Cell"},{"issue":"5858","key":"6_CR2","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1126\/science.1149460","volume":"318","author":"S Vasudevan","year":"2007","unstructured":"Vasudevan, S., Tong, Y., Steitz, J.A.: Switching from repression to activation: micrornas can up-regulate translation. Science 318(5858), 1931\u20131934 (2007)","journal-title":"Science"},{"issue":"5871","key":"6_CR3","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1126\/science.1151651","volume":"319","author":"O Hobert","year":"2008","unstructured":"Hobert, O.: Gene regulation by transcription factors and microRNAs. Science 319(5871), 1785\u20131786 (2008)","journal-title":"Science"},{"issue":"1","key":"6_CR4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","volume":"79","author":"MR Fabian","year":"2010","unstructured":"Fabian, M.R., Sonenberg, N., Filipowicz, W.: Regulation of mRNA translation and stability by microRNAs. Ann. Rev. Biochem. 79(1), 351\u2013379 (2010)","journal-title":"Ann. Rev. Biochem."},{"issue":"2","key":"6_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrg2936","volume":"12","author":"E Huntzinger","year":"2011","unstructured":"Huntzinger, E., Izaurralde, E.: Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat. Rev. Genet. 12(2), 99\u2013110 (2011)","journal-title":"Nat. Rev. Genet."},{"issue":"7308","key":"6_CR6","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nature09267","volume":"466","author":"H Guo","year":"2010","unstructured":"Guo, H., et al.: Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466(7308), 835\u2013840 (2010)","journal-title":"Nature"},{"issue":"1","key":"6_CR7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1101\/gr.082701.108","volume":"19","author":"RC Friedman","year":"2009","unstructured":"Friedman, R.C., et al.: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19(1), 92\u2013105 (2009)","journal-title":"Genome Res."},{"issue":"10","key":"6_CR8","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nrg2634","volume":"10","author":"CM Croce","year":"2009","unstructured":"Croce, C.M.: Causes and consequences of microRNA dysregulation in cancer. Nat. Rev. Genet. 10(10), 704\u2013714 (2009)","journal-title":"Nat. Rev. Genet."},{"issue":"7385","key":"6_CR9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nature10888","volume":"482","author":"A Lujambio","year":"2012","unstructured":"Lujambio, A., Lowe, S.W.: The microcosmos of cancer. Nature 482(7385), 347\u2013355 (2012)","journal-title":"Nature"},{"issue":"1\u20132","key":"6_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2009.11.008","volume":"451","author":"UA \u00d8rom","year":"2010","unstructured":"\u00d8rom, U.A., Lund, A.H.: Experimental identification of microRNA targets. Gene 451(1\u20132), 1\u20135 (2010)","journal-title":"Gene"},{"key":"6_CR11","doi-asserted-by":"crossref","unstructured":"Vergoulis, T., et al.: TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support. Nucleic Acids Res. 40, D222\u2013D229 (2011)","DOI":"10.1093\/nar\/gkr1161"},{"key":"6_CR12","doi-asserted-by":"crossref","unstructured":"Hsu, S.D., et al.: miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions. Nucleic Acids Res. 42(Database issue), D78\u2013D85 (2014)","DOI":"10.1093\/nar\/gkt1266"},{"issue":"11","key":"6_CR13","doi-asserted-by":"publisher","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","volume":"2","author":"B John","year":"2004","unstructured":"John, B., et al.: Human microRNA targets. PLoS Biol. 2(11), e363 (2004)","journal-title":"PLoS Biol."},{"issue":"5","key":"6_CR14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ng1536","volume":"37","author":"A Krek","year":"2005","unstructured":"Krek, A., et al.: Combinatorial microRNA target predictions. Nat. Genet. 37(5), 495\u2013500 (2005)","journal-title":"Nat. Genet."},{"issue":"1","key":"6_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis, B.P., Burge, C.B., Bartel, D.P.: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120(1), 15\u201320 (2005)","journal-title":"Cell"},{"key":"6_CR16","doi-asserted-by":"crossref","unstructured":"Maragkakis, M., et al.: DIANA-microT web server: elucidating microRNA functions through target prediction. Nucleic Acids Res. 37(Web Server issue), W273\u2013W276 (2009)","DOI":"10.1093\/nar\/gkp292"},{"issue":"11","key":"6_CR17","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/nmeth954","volume":"3","author":"P Sethupathy","year":"2006","unstructured":"Sethupathy, P., Megraw, M., Hatzigeorgiou, A.G.: A guide through present computational approaches for the identification of mammalian microRNA targets. Nat. Methods 3(11), 881\u2013886 (2006)","journal-title":"Nat. Methods"},{"issue":"5","key":"6_CR18","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nrg3198","volume":"13","author":"CC Pritchard","year":"2012","unstructured":"Pritchard, C.C., Cheng, H.H., Tewari, M.: MicroRNA profiling: approaches and considerations. Nat. Rev. Genet. 13(5), 358\u2013369 (2012)","journal-title":"Nat. Rev. Genet."},{"issue":"Suppl. 1","key":"6_CR19","first-page":"D159","volume":"36","author":"S Nam","year":"2008","unstructured":"Nam, S., et al.: miRGator: an integrated system for functional annotation of microRNAs. Nucleic Acids Res. 36(Suppl. 1), D159\u2013D164 (2008)","journal-title":"Nucleic Acids Res."},{"issue":"Suppl. 2","key":"6_CR20","doi-asserted-by":"publisher","first-page":"W416","DOI":"10.1093\/nar\/gkr276","volume":"39","author":"GT Huang","year":"2011","unstructured":"Huang, G.T., Athanassiou, C., Benos, P.V.: mirConnX: condition-specific mRNA-microRNA network integrator. Nucleic Acids Res. 39(Suppl. 2), W416\u2013W423 (2011)","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"6_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/bioinformatics\/btp649","volume":"26","author":"W Ritchie","year":"2010","unstructured":"Ritchie, W., Flamant, S., Rasko, J.E.J.: mimiRNA: a microRNA expression profiler and classification resource designed to identify functional correlations between microRNAs and their targets. Bioinformatics 26(2), 223\u2013227 (2010)","journal-title":"Bioinformatics"},{"issue":"1","key":"6_CR22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/1471-2164-10-373","volume":"10","author":"X Peng","year":"2009","unstructured":"Peng, X., et al.: Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. BMC Genom. 10(1), 373 (2009)","journal-title":"BMC Genom."},{"issue":"Suppl. 2","key":"6_CR23","doi-asserted-by":"publisher","first-page":"W352","DOI":"10.1093\/nar\/gkq423","volume":"38","author":"G Sales","year":"2010","unstructured":"Sales, G., et al.: MAGIA, a web-based tool for miRNA and genes integrated analysis. Nucleic Acids Res. 38(Suppl. 2), W352\u2013W359 (2010)","journal-title":"Nucleic Acids Res."},{"issue":"Suppl. 2","key":"6_CR24","doi-asserted-by":"publisher","first-page":"W356","DOI":"10.1093\/nar\/gkp294","volume":"37","author":"S Nam","year":"2009","unstructured":"Nam, S., et al.: MicroRNA and mRNA integrated analysis (MMIA): a web tool for examining biological functions of microRNA expression. Nucleic Acids Res. 37(Suppl. 2), W356\u2013W362 (2009)","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"6_CR25","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.compbiolchem.2008.07.016","volume":"33","author":"S Kim","year":"2009","unstructured":"Kim, S., Choi, M., Cho, K.H.: Identifying the target mRNAs of microRNAs in colorectal cancer. Comput. Biol. Chem. 33(1), 94\u201399 (2009)","journal-title":"Comput. Biol. Chem."},{"issue":"4","key":"6_CR26","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.jtbi.2009.05.007","volume":"259","author":"H Wang","year":"2009","unstructured":"Wang, H., Li, W.H.: Increasing MicroRNA target prediction confidence by the relative R(2) method. J. Theoret. Biol. 259(4), 793\u2013798 (2009)","journal-title":"J. Theoret. Biol."},{"issue":"1","key":"6_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1755-8794-4-19","volume":"4","author":"D Beck","year":"2011","unstructured":"Beck, D., et al.: Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in myelodysplastic syndromes. BMC Med. Genom. 4(1), 19 (2011)","journal-title":"BMC Med. Genom."},{"issue":"5","key":"6_CR28","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1089\/cmb.2007.R002","volume":"14","author":"JC Huang","year":"2007","unstructured":"Huang, J.C., Morris, Q.D., Frey, B.J.: Bayesian inference of MicroRNA targets from sequence and expression data. J. Comput. Biol. 14(5), 550\u2013563 (2007)","journal-title":"J. Comput. Biol."},{"key":"6_CR29","unstructured":"Huang, J.C., Frey, B.J., Morris, Q.D.: Comparing sequence and expression for predicting microRNA targets using GenMiR3. In: Pacific Symposium on Biocomputing, pp. 52\u201363 (2008)"},{"key":"6_CR30","doi-asserted-by":"crossref","unstructured":"Su, N., et al.: Predicting microRNA targets by integrating sequence and expression data in cancer. In: 2011 IEEE International Conference on Systems Biology (ISB) (2011)","DOI":"10.1109\/ISB.2011.6033158"},{"issue":"4","key":"6_CR31","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1214\/10-AOAS360","volume":"4","author":"FC Stingo","year":"2010","unstructured":"Stingo, F.C., et al.: A Bayesian graphical modeling approach to microRNA regulatory network inference. Ann. Appl. Stat. 4(4), 2024\u20132048 (2010)","journal-title":"Ann. Appl. Stat."},{"issue":"1","key":"6_CR32","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1186\/1471-2105-10-408","volume":"10","author":"B Liu","year":"2009","unstructured":"Liu, B., et al.: Exploring complex miRNA-mRNA interactions with Bayesian networks by splitting-averaging strategy. BMC Bioinform. 10(1), 408 (2009)","journal-title":"BMC Bioinform."},{"issue":"1\u20132","key":"6_CR33","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s13721-012-0008-4","volume":"1","author":"Y Zhou","year":"2012","unstructured":"Zhou, Y., Qureshi, R., Sacan, A.: Data simulation and regulatory network reconstruction from time-series microarray data using stepwise multiple linear regression. Netw. Model. Anal. Health Inform. Bioinform. 1(1\u20132), 3\u201317 (2012)","journal-title":"Netw. Model. Anal. Health Inform. Bioinform."},{"issue":"1","key":"6_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/bib\/bbs075","volume":"15","author":"B Liu","year":"2014","unstructured":"Liu, B., Li, J., Cairns, M.J.: Identifying miRNAs, targets and functions. Briefings Bioinform. 15(1), 1\u201319 (2014)","journal-title":"Briefings Bioinform."},{"issue":"1","key":"6_CR35","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W da Huang","year":"2009","unstructured":"da Huang, W., Sherman, B.T., Lempicki, R.A.: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4(1), 44\u201357 (2009)","journal-title":"Nat. Protoc."},{"issue":"2","key":"6_CR36","doi-asserted-by":"publisher","first-page":"e16915","DOI":"10.1371\/journal.pone.0016915","volume":"6","author":"E Enerly","year":"2011","unstructured":"Enerly, E., et al.: miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors. PLoS ONE 6(2), e16915 (2011)","journal-title":"PLoS ONE"},{"issue":"17","key":"6_CR37","doi-asserted-by":"publisher","first-page":"5635","DOI":"10.1158\/0008-5472.CAN-11-0489","volume":"71","author":"FM Buffa","year":"2011","unstructured":"Buffa, F.M., et al.: microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer. Cancer Res. 71(17), 5635\u20135645 (2011)","journal-title":"Cancer Res."},{"issue":"12","key":"6_CR38","first-page":"4122","volume":"7","author":"B Naume","year":"2001","unstructured":"Naume, B., et al.: Detection of isolated tumor cells in bone marrow in early-stage breast carcinoma patients: comparison with preoperative clinical parameters and primary tumor characteristics. Clin. Cancer Res. 7(12), 4122\u20134129 (2001)","journal-title":"Clin. Cancer Res."}],"container-title":["Lecture Notes in Computer Science","Bioinformatics Research and Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-59575-7_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T14:47:22Z","timestamp":1709822842000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-319-59575-7_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319595740","9783319595757"],"references-count":38,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-59575-7_6","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"31 May 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"ISBRA","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Symposium on Bioinformatics Research and Applications","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Honolulu","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"USA","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2017","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"29 May 2017","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2 June 2017","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"13","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"isbra2017","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/alan.cs.gsu.edu\/isbra17\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}