{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:31:58Z","timestamp":1790224318155,"version":"4.1.0"},"publisher-location":"Cham","reference-count":55,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319632445","type":"print"},{"value":"9783319632452","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-63245-2_15","type":"book-chapter","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T09:23:16Z","timestamp":1508232196000},"page":"261-276","source":"Crossref","is-referenced-by-count":11,"title":["Hydrogen Sulfide as an O2 Sensor: A Critical Analysis"],"prefix":"10.1007","author":[{"given":"Jesus","family":"Prieto-Lloret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip I.","family":"Aaronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,18]]},"reference":[{"issue":"3","key":"15_CR1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","volume":"237","author":"R Hosoki","year":"1997","unstructured":"Hosoki, R., Matsuki, N., & Kimura, H. (1997). The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochemical and Biophysical Research Communications, 237(3), 527\u2013531. doi:\n10.1006\/bbrc.1997.6878\n\n.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"15_CR2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1871525714999160201121220","volume":"14","author":"J Brampton","year":"2016","unstructured":"Brampton, J., & Aaronson, P. I. (2016). Role of hydrogen sulfide in systemic and pulmonary hypertension: Cellular mechanisms and therapeutic implications. Cardiovascular & Hematological Agents in Medicinal Chemistry, 14(1), 4\u201322.","journal-title":"Cardiovascular & Hematological Agents in Medicinal Chemistry"},{"issue":"Pt 20","key":"15_CR3","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1242\/jeb.02480","volume":"209","author":"KR Olson","year":"2006","unstructured":"Olson, K. R., Dombkowski, R. A., Russell, M. J., Doellman, M. M., Head, S. K., Whitfield, N. L., & Madden, J. A. (2006). Hydrogen sulfide as an oxygen sensor\/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation. The Journal of Experimental Biology, 209(Pt 20), 4011\u20134023. doi:\n10.1242\/jeb.02480\n\n.","journal-title":"The Journal of Experimental Biology"},{"issue":"1","key":"15_CR4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1152\/physrev.00041.2010","volume":"92","author":"JT Sylvester","year":"2012","unstructured":"Sylvester, J. T., Shimoda, L. A., Aaronson, P. I., & Ward, J. P. (2012). Hypoxic pulmonary vasoconstriction. Physiological Reviews, 92(1), 367\u2013520. doi:\n10.1152\/physrev.00041.2010\n\n.","journal-title":"Physiological Reviews"},{"issue":"2","key":"15_CR5","doi-asserted-by":"publisher","first-page":"R669","DOI":"10.1152\/ajpregu.00807.2007","volume":"295","author":"KR Olson","year":"2008","unstructured":"Olson, K. R., Healy, M. J., Qin, Z., Skovgaard, N., Vulesevic, B., Duff, D. W., Whitfield, N. L., Yang, G., Wang, R., & Perry, S. F. (2008). Hydrogen sulfide as an oxygen sensor in trout gill chemoreceptors. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 295(2), R669\u2013R680. doi:\n10.1152\/ajpregu.00807.2007\n\n.","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"issue":"2","key":"15_CR6","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1152\/physrev.00017.2011","volume":"92","author":"R Wang","year":"2012","unstructured":"Wang, R. (2012). Physiological implications of hydrogen sulfide: A whiff exploration that blossomed. Physiological Reviews, 92(2), 791\u2013896. doi:\n10.1152\/physrev.00017.2011\n\n.","journal-title":"Physiological Reviews"},{"issue":"6","key":"15_CR7","doi-asserted-by":"publisher","first-page":"R592","DOI":"10.1152\/ajpregu.00421.2012","volume":"305","author":"KR Olson","year":"2013","unstructured":"Olson, K. R., Deleon, E. R., Gao, Y., Hurley, K., Sadauskas, V., Batz, C., & Stoy, G. F. (2013). Thiosulfate: A readily accessible source of hydrogen sulfide in oxygen sensing. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 305(6), R592\u2013R603. doi:\n10.1152\/ajpregu.00421.2012\n\n.","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"15_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.niox.2014.01.002","volume":"41","author":"H Kimura","year":"2014","unstructured":"Kimura, H. (2014). The physiological role of hydrogen sulfide and beyond. Nitric Oxide, 41, 4\u201310. doi:\n10.1016\/j.niox.2014.01.002\n\n.","journal-title":"Nitric Oxide"},{"issue":"2","key":"15_CR9","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1089\/ars.2010.3678","volume":"15","author":"F Bouillaud","year":"2011","unstructured":"Bouillaud, F., & Blachier, F. (2011). Mitochondria and sulfide: A very old story of poisoning, feeding, and signaling? Antioxidants & Redox Signaling, 15(2), 379\u2013391. doi:\n10.1089\/ars.2010.3678\n\n.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"8","key":"15_CR10","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1111\/bph.12369","volume":"171","author":"C Szabo","year":"2014","unstructured":"Szabo, C., Ransy, C., Modis, K., Andriamihaja, M., Murghes, B., Coletta, C., Olah, G., Yanagi, K., & Bouillaud, F. (2014). Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms. British Journal of Pharmacology, 171(8), 2099\u20132122. doi:\n10.1111\/bph.12369\n\n.","journal-title":"British Journal of Pharmacology"},{"issue":"5901","key":"15_CR11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","volume":"322","author":"G Yang","year":"2008","unstructured":"Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., Snyder, S. H., & Wang, R. (2008). H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase. Science, 322(5901), 587\u2013590. doi:\n10.1126\/science.1162667\n\n.","journal-title":"Science"},{"issue":"2","key":"15_CR12","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bbrc.2013.01.010","volume":"431","author":"Y Mikami","year":"2013","unstructured":"Mikami, Y., Shibuya, N., Ogasawara, Y., & Kimura, H. (2013). Hydrogen sulfide is produced by cystathionine gamma-lyase at the steady-state low intracellular Ca(2+) concentrations. Biochemical and Biophysical Research Communications, 431(2), 131\u2013135. doi:\n10.1016\/j.bbrc.2013.01.010\n\n.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"373","key":"15_CR13","doi-asserted-by":"publisher","first-page":"ra37","DOI":"10.1126\/scisignal.2005846","volume":"8","author":"G Yuan","year":"2015","unstructured":"Yuan, G., Vasavda, C., Peng, Y. J., Makarenko, V. V., Raghuraman, G., Nanduri, J., Gadalla, M. M., Semenza, G. L., Kumar, G. K., Snyder, S. H., & Prabhakar, N. R. (2015). Protein kinase G-regulated production of H2S governs oxygen sensing. Science Signaling, 8(373), ra37. doi:\n10.1126\/scisignal.2005846\n\n.","journal-title":"Science Signaling"},{"key":"15_CR14","doi-asserted-by":"publisher","first-page":"14774","DOI":"10.1038\/srep14774","volume":"5","author":"Y Kimura","year":"2015","unstructured":"Kimura, Y., Toyofuku, Y., Koike, S., Shibuya, N., Nagahara, N., Lefer, D., Ogasawara, Y., & Kimura, H. (2015). Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain. Scientific Reports, 5, 14774. doi:\n10.1038\/srep14774\n\n.","journal-title":"Scientific Reports"},{"issue":"11","key":"15_CR15","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s00702-016-1600-z","volume":"123","author":"H Kimura","year":"2016","unstructured":"Kimura, H. (2016). Hydrogen polysulfide (H2S n ) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO). Journal of Neural Transmission, 123(11), 1235\u20131245. doi:\n10.1007\/s00702-016-1600-z\n\n.","journal-title":"Journal of Neural Transmission"},{"issue":"34","key":"15_CR16","doi-asserted-by":"publisher","first-page":"E4651","DOI":"10.1073\/pnas.1509277112","volume":"112","author":"MM Cortese-Krott","year":"2015","unstructured":"Cortese-Krott, M. M., Kuhnle, G. G., Dyson, A., Fernandez, B. O., Grman, M., DuMond, J. F., Barrow, M. P., McLeod, G., Nakagawa, H., Ondrias, K., Nagy, P., King, S. B., Saavedra, J. E., Keefer, L. K., Singer, M., Kelm, M., Butler, A. R., & Feelisch, M. (2015). Key bioactive reaction products of the NO\/H2S interaction are S\/N-hybrid species, polysulfides, and nitroxyl. Proceedings of the National Academy of Sciences of the United States of America, 112(34), E4651\u2013E4660. doi:\n10.1073\/pnas.1509277112\n\n.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"15_CR17","doi-asserted-by":"publisher","first-page":"4381","DOI":"10.1038\/ncomms5381","volume":"5","author":"M Eberhardt","year":"2014","unstructured":"Eberhardt, M., Dux, M., Namer, B., Miljkovic, J., Cordasic, N., Will, C., Kichko, T. I., de la Roche, J., Fischer, M., Suarez, S. A., Bikiel, D., Dorsch, K., Leffler, A., Babes, A., Lampert, A., Lennerz, J. K., Jacobi, J., Marti, M. A., Doctorovich, F., Hogestatt, E. D., Zygmunt, P. M., Ivanovic-Burmazovic, I., Messlinger, K., Reeh, P., & Filipovic, M. R. (2014). H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Nature Communications, 5, 4381. doi:\n10.1038\/ncomms5381\n\n.","journal-title":"Nature Communications"},{"issue":"32","key":"15_CR18","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.2174\/0929867321666140706142335","volume":"21","author":"S Pushpakumar","year":"2014","unstructured":"Pushpakumar, S., Kundu, S., & Sen, U. (2014). Endothelial dysfunction: The link between homocysteine and hydrogen sulfide. Current Medicinal Chemistry, 21(32), 3662\u20133672.","journal-title":"Current Medicinal Chemistry"},{"issue":"23","key":"15_CR19","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1073\/pnas.1005866107","volume":"107","author":"YJ Peng","year":"2010","unstructured":"Peng, Y. J., Nanduri, J., Raghuraman, G., Souvannakitti, D., Gadalla, M. M., Kumar, G. K., Snyder, S. H., & Prabhakar, N. R. (2010). H2S mediates O2 sensing in the carotid body. Proceedings of the National Academy of Sciences of the United States of America, 107(23), 10719\u201310724.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"15_CR20","doi-asserted-by":"publisher","first-page":"R243","DOI":"10.1152\/ajpregu.00324.2004","volume":"288","author":"RA Dombkowski","year":"2005","unstructured":"Dombkowski, R. A., Russell, M. J., Schulman, A. A., Doellman, M. M., & Olson, K. R. (2005). Vertebrate phylogeny of hydrogen sulfide vasoactivity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 288(1), R243\u2013R252. doi:\n10.1152\/ajpregu.00324.2004\n\n.","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"issue":"2","key":"15_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/jez.427","volume":"309","author":"MJ Russell","year":"2008","unstructured":"Russell, M. J., Dombkowski, R. A., & Olson, K. R. (2008). Effects of hypoxia on vertebrate blood vessels. Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology, 309(2), 55\u201363. doi:\n10.1002\/jez.427\n\n.","journal-title":"Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology"},{"issue":"3","key":"15_CR22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1152\/japplphysiol.01049.2011","volume":"112","author":"JA Madden","year":"2012","unstructured":"Madden, J. A., Ahlf, S. B., Dantuma, M. W., Olson, K. R., & Roerig, D. L. (2012). Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung. Journal of Applied Physiology, 112(3), 411\u2013418. doi:\n10.1152\/japplphysiol.01049.2011\n\n.","journal-title":"Journal of Applied Physiology"},{"issue":"10","key":"15_CR23","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1089\/ars.2009.2921","volume":"12","author":"KR Olson","year":"2010","unstructured":"Olson, K. R., & Whitfield, N. L. (2010). Hydrogen sulfide and oxygen sensing in the cardiovascular system. Antioxidants & Redox Signaling, 12(10), 1219\u20131234. doi:\n10.1089\/ars.2009.2921\n\n.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"1","key":"15_CR24","doi-asserted-by":"publisher","first-page":"R51","DOI":"10.1152\/ajpregu.00576.2009","volume":"298","author":"KR Olson","year":"2010","unstructured":"Olson, K. R., Whitfield, N. L., Bearden, S. E., St Leger, J., Nilson, E., Gao, Y., & Madden, J. A. (2010). Hypoxic pulmonary vasodilation: A paradigm shift with a hydrogen sulfide mechanism. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 298(1), R51\u2013R60. doi:\n10.1152\/ajpregu.00576.2009\n\n.","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"issue":"5","key":"15_CR25","doi-asserted-by":"publisher","first-page":"R487","DOI":"10.1152\/ajpregu.00151.2012","volume":"303","author":"N Skovgaard","year":"2012","unstructured":"Skovgaard, N., & Olson, K. R. (2012). Hydrogen sulfide mediates hypoxic vasoconstriction through a production of mitochondrial ROS in trout gills. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 303(5), R487\u2013R494. doi:\n10.1152\/ajpregu.00151.2012\n\n.","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"issue":"4","key":"15_CR26","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0006-291X(03)00256-0","volume":"302","author":"Z Chunyu","year":"2003","unstructured":"Chunyu, Z., Junbao, D., Dingfang, B., Hui, Y., Xiuying, T., & Chaoshu, T. (2003). The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats. Biochemical and Biophysical Research Communications, 302(4), 810\u2013816.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"2","key":"15_CR27","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1113\/jphysiol.2014.277046","volume":"593","author":"J Prieto-Lloret","year":"2015","unstructured":"Prieto-Lloret, J., Shaifta, Y., Ward, J. P., & Aaronson, P. I. (2015). Hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries is not inhibited by antagonists of H2 S-synthesizing pathways. The Journal of Physiology, 593(2), 385\u2013401. doi:\n10.1113\/jphysiol.2014.277046\n\n.","journal-title":"The Journal of Physiology"},{"issue":"11","key":"15_CR28","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1253\/circj.69.1418","volume":"69","author":"L Xiaohui","year":"2005","unstructured":"Xiaohui, L., Junbao, D., Lin, S., Jian, L., Xiuying, T., Jianguang, Q., Bing, W., Hongfang, J., & Chaoshu, T. (2005). Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats. Circulation Journal, 69(11), 1418\u20131424.","journal-title":"Circulation Journal"},{"issue":"3","key":"15_CR29","doi-asserted-by":"publisher","first-page":"R607","DOI":"10.1152\/ajpregu.00177.2016","volume":"311","author":"NC Krause","year":"2016","unstructured":"Krause, N. C., Kutsche, H. S., Santangelo, F., DeLeon, E. R., Dittrich, N. P., Olson, K. R., & Althaus, M. (2016). Hydrogen sulfide contributes to hypoxic inhibition of airway transepithelial sodium absorption. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(3), R607\u2013R617. doi:\n10.1152\/ajpregu.00177.2016\n\n.","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"15_CR30","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-3-319-18440-1_10","volume":"860","author":"J Prieto-Lloret","year":"2015","unstructured":"Prieto-Lloret, J., & Aaronson, P. I. (2015). Potentiation of hypoxic pulmonary vasoconstriction by hydrogen sulfide precursors 3-mercaptopyruvate and D-cysteine is blocked by the cystathionine gamma lyase inhibitor propargylglycine. Advances in Experimental Medicine and Biology, 860, 81\u201387. doi:\n10.1007\/978-3-319-18440-1_10\n\n.","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"Pt 14","key":"15_CR31","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1242\/jeb.016766","volume":"211","author":"KR Olson","year":"2008","unstructured":"Olson, K. R., Forgan, L. G., Dombkowski, R. A., & Forster, M. E. (2008). Oxygen dependency of hydrogen sulfide-mediated vasoconstriction in cyclostome aortas. The Journal of Experimental Biology, 211(Pt 14), 2205\u20132213. doi:\n10.1242\/jeb.016766\n\n.","journal-title":"The Journal of Experimental Biology"},{"issue":"4","key":"15_CR32","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1111\/bph.12171","volume":"169","author":"A Asimakopoulou","year":"2013","unstructured":"Asimakopoulou, A., Panopoulos, P., Chasapis, C. T., Coletta, C., Zhou, Z., Cirino, G., Giannis, A., Szabo, C., Spyroulias, G. A., & Papapetropoulos, A. (2013). Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE). British Journal of Pharmacology, 169(4), 922\u2013932. doi:\n10.1111\/bph.12171\n\n.","journal-title":"British Journal of Pharmacology"},{"issue":"3","key":"15_CR33","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1161\/CIRCRESAHA.109.206334","volume":"106","author":"GB Waypa","year":"2010","unstructured":"Waypa, G. B., Marks, J. D., Guzy, R., Mungai, P. T., Schriewer, J., Dokic, D., & Schumacker, P. T. (2010). Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circulation Research, 106(3), 526\u2013535. doi:\n10.1161\/CIRCRESAHA.109.206334\n\n.","journal-title":"Circulation Research"},{"issue":"4","key":"15_CR34","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.freeradbiomed.2010.11.029","volume":"50","author":"YM Go","year":"2011","unstructured":"Go, Y. M., & Jones, D. P. (2011). Cysteine\/cystine redox signaling in cardiovascular disease. Free Radical Biology & Medicine, 50(4), 495\u2013509. doi:\n10.1016\/j.freeradbiomed.2010.11.029\n\n.","journal-title":"Free Radical Biology & Medicine"},{"issue":"10","key":"15_CR35","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/j.freeradbiomed.2008.08.020","volume":"45","author":"GE Pourmahram","year":"2008","unstructured":"Pourmahram, G. E., Snetkov, V. A., Shaifta, Y., Drndarski, S., Knock, G. A., Aaronson, P. I., & Ward, J. P. (2008). Constriction of pulmonary artery by peroxide: Role of Ca2+ release and PKC. Free Radical Biology & Medicine, 45(10), 1468\u20131476. doi:\n10.1016\/j.freeradbiomed.2008.08.020\n\n.","journal-title":"Free Radical Biology & Medicine"},{"issue":"4","key":"15_CR36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1440-1681.2002.03649.x","volume":"29","author":"Y Liu","year":"2002","unstructured":"Liu, Y., & Gutterman, D. D. (2002). Oxidative stress and potassium channel function. Clinical and Experimental Pharmacology & Physiology, 29(4), 305\u2013311.","journal-title":"Clinical and Experimental Pharmacology & Physiology"},{"key":"15_CR37","first-page":"C80","volume":"23","author":"J Prieto-Lloret","year":"2011","unstructured":"Prieto-Lloret, J., Snetkov, V., Connolly, M. J., Ward, J. P., & Aaronson, P. I. (2011). Mechanism of hydrogen sulfide mediated contraction in rat small pulmonary arteries. Proceedings of the Physiological Society, 23, C80.","journal-title":"Proceedings of the Physiological Society"},{"key":"15_CR38","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.mam.2016.01.002","volume":"47\u201348","author":"GB Waypa","year":"2016","unstructured":"Waypa, G. B., Smith, K. A., & Schumacker, P. T. (2016). O2 sensing, mitochondria and ROS signalling: The fog is lifting. Molecular Aspects of Medicine, 47\u201348, 76\u201389. doi:\n10.1016\/j.mam.2016.01.002\n\n.","journal-title":"Molecular Aspects of Medicine"},{"issue":"3","key":"15_CR39","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/j.1469-7793.2000.t01-1-00669.x","volume":"525","author":"TP Robertson","year":"2000","unstructured":"Robertson, T. P., Hague, D., Aaronson, P. I., & Ward, J. P. (2000). Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat. The Journal of Physiology, 525(3), 669\u2013680. doi:\n10.1111\/j.1469-7793.2000.t01-1-00669.x\n\n.","journal-title":"The Journal of Physiology"},{"issue":"4","key":"15_CR40","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0166-2236(92)90357-E","volume":"15","author":"C Gonzalez","year":"1992","unstructured":"Gonzalez, C., Almaraz, L., Obeso, A., & Rigual, R. (1992). Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends in Neurosciences, 15(4), 146\u2013153.","journal-title":"Trends in Neurosciences"},{"issue":"9","key":"15_CR41","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.2337\/diabetes.49.9.1434","volume":"49","author":"Y Koyama","year":"2000","unstructured":"Koyama, Y., Coker, R. H., Stone, E. E., Lacy, D. B., Jabbour, K., Williams, P. E., & Wasserman, D. H. (2000). Evidence that carotid bodies play an important role in glucoregulation in vivo. Diabetes, 49(9), 1434\u20131442.","journal-title":"Diabetes"},{"issue":"8","key":"15_CR42","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.2337\/db12-1463","volume":"62","author":"MJ Ribeiro","year":"2013","unstructured":"Ribeiro, M. J., Sacramento, J. F., Gonzalez, C., Guarino, M. P., Monteiro, E. C., & Conde, S. V. (2013). Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets. Diabetes, 62(8), 2905\u20132916. doi:\n10.2337\/db12-1463\n\n.","journal-title":"Diabetes"},{"issue":"5","key":"15_CR43","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1089\/ars.2013.5377","volume":"20","author":"PJ Kemp","year":"2014","unstructured":"Kemp, P. J., & Telezhkin, V. (2014). Oxygen sensing by the carotid body: Is it all just rotten eggs? Antioxidants & Redox Signaling, 20(5), 794\u2013804. doi:\n10.1089\/ars.2013.5377\n\n.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"10","key":"15_CR44","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1089\/ars.2009.2926","volume":"12","author":"Q Li","year":"2010","unstructured":"Li, Q., Sun, B., Wang, X., Jin, Z., Zhou, Y., Dong, L., Jiang, L. H., & Rong, W. (2010). A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels. Antioxidants & Redox Signaling, 12(10), 1179\u20131189. doi:\n10.1089\/ars.2009.2926\n\n.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"9","key":"15_CR45","doi-asserted-by":"publisher","first-page":"C916","DOI":"10.1152\/ajpcell.00100.2012","volume":"303","author":"VV Makarenko","year":"2012","unstructured":"Makarenko, V. V., Nanduri, J., Raghuraman, G., Fox, A. P., Gadalla, M. M., Kumar, G. K., Snyder, S. H., & Prabhakar, N. R. (2012). Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. American Journal of Physiology. Cell Physiology, 303(9), C916\u2013C923. doi:\n10.1152\/ajpcell.00100.2012\n\n.","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"6","key":"15_CR46","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1073\/pnas.92.6.1994","volume":"92","author":"NR Prabhakar","year":"1995","unstructured":"Prabhakar, N. R., Dinerman, J. L., Agani, F. H., & Snyder, S. H. (1995). Carbon monoxide: A role in carotid body chemoreception. Proceedings of the National Academy of Sciences of the United States of America, 92(6), 1994\u20131997.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"15_CR47","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-90-481-2259-2_7","volume":"648","author":"V Telezhkin","year":"2009","unstructured":"Telezhkin, V., Brazier, S. P., Cayzac, S., Muller, C. T., Riccardi, D., & Kemp, P. J. (2009). Hydrogen sulfide inhibits human BK(Ca) channels. Advances in Experimental Medicine and Biology, 648, 65\u201372. doi:\n10.1007\/978-90-481-2259-2_7\n\n.","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"15_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.resp.2015.01.002","volume":"208","author":"Y Jiao","year":"2015","unstructured":"Jiao, Y., Li, Q., Sun, B., Zhang, G., & Rong, W. (2015). Hydrogen sulfide activates the carotid body chemoreceptors in cat, rabbit and rat ex vivo preparations. Respiratory Physiology & Neurobiology, 208, 15\u201320. doi:\n10.1016\/j.resp.2015.01.002\n\n.","journal-title":"Respiratory Physiology & Neurobiology"},{"issue":"9","key":"15_CR49","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1152\/japplphysiol.01503.2012","volume":"114","author":"R Rio Del","year":"2013","unstructured":"Del Rio, R., Marcus, N. J., & Schultz, H. D. (2013). Inhibition of hydrogen sulfide restores normal breathing stability and improves autonomic control during experimental heart failure. Journal of Applied Physiology, 114(9), 1141\u20131150. doi:\n10.1152\/japplphysiol.01503.2012\n\n.","journal-title":"Journal of Applied Physiology"},{"issue":"3","key":"15_CR50","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1161\/CIRCRESAHA.109.206946","volume":"106","author":"ZY Tan","year":"2010","unstructured":"Tan, Z. Y., Lu, Y., Whiteis, C. A., Simms, A. E., Paton, J. F., Chapleau, M. W., & Abboud, F. M. (2010). Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR. Circulation Research, 106(3), 536\u2013545. doi:\n10.1161\/CIRCRESAHA.109.206946\n\n.","journal-title":"Circulation Research"},{"issue":"3","key":"15_CR51","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1073\/pnas.1322172111","volume":"111","author":"YJ Peng","year":"2014","unstructured":"Peng, Y. J., Makarenko, V. V., Nanduri, J., Vasavda, C., Raghuraman, G., Yuan, G., Gadalla, M. M., Kumar, G. K., Snyder, S. H., & Prabhakar, N. R. (2014). Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proceedings of the National Academy of Sciences of the United States of America, 111(3), 1174\u20131179. doi:\n10.1073\/pnas.1322172111\n\n.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"373","key":"15_CR52","doi-asserted-by":"publisher","first-page":"fs10","DOI":"10.1126\/scisignal.aab1665","volume":"8","author":"J Fandrey","year":"2015","unstructured":"Fandrey, J. (2015). Rounding up the usual suspects in O2 sensing: CO, NO, and H2S! Science Signaling, 8(373), fs10. doi:\n10.1126\/scisignal.aab1665\n\n.","journal-title":"Science Signaling"},{"issue":"5","key":"15_CR53","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00424-012-1089-8","volume":"463","author":"KJ Buckler","year":"2012","unstructured":"Buckler, K. J. (2012). Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells. Pfl\u00fcgers Archiv, 463(5), 743\u2013754. doi:\n10.1007\/s00424-012-1089-8\n\n.","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"3","key":"15_CR54","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.resp.2010.05.01","volume":"172","author":"V Telezhkin","year":"2010","unstructured":"Telezhkin, V., Brazier, S. P., Cayzac, S. H., Wilkinson, W. J., Riccardi, D., & Kemp, P. J. (2010). Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels. Respiratory Physiology & Neurobiology, 172(3), 169\u2013178. doi:\n10.1016\/j.resp.2010.05.01\n\n.","journal-title":"Respiratory Physiology & Neurobiology"},{"issue":"22","key":"15_CR55","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.lfs.2007.03.003","volume":"80","author":"B Cai","year":"2007","unstructured":"Cai, B., Gong, D., Pan, Z., Liu, Y., Qian, H., Zhang, Y., Jiao, J., Lu, Y., & Yang, B. (2007). Large-conductance Ca2+\u2212activated K+ currents blocked and impaired by homocysteine in human and rat mesenteric artery smooth muscle cells. Life Sciences, 80(22), 2060\u20132066. doi:\n10.1016\/j.lfs.2007.03.003\n\n.","journal-title":"Life Sciences"}],"container-title":["Advances in Experimental Medicine and Biology","Pulmonary Vasculature Redox Signaling in Health and Disease"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-63245-2_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T09:29:13Z","timestamp":1508232553000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-63245-2_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319632445","9783319632452"],"references-count":55,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-63245-2_15","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}