{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:07:22Z","timestamp":1792652842501,"version":"4.5.0"},"publisher-location":"Cham","reference-count":33,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319673578","type":"print"},{"value":"9783319673585","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-67358-5_2","type":"book-chapter","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T09:34:37Z","timestamp":1509096877000},"page":"19-30","source":"Crossref","is-referenced-by-count":15,"title":["Simultaneous Phosphorescence and Fluorescence Lifetime Imaging by Multi-Dimensional TCSPC and Multi-Pulse Excitation"],"prefix":"10.1007","author":[{"given":"Wolfgang","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Shcheslavskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"R\u00fcck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,28]]},"reference":[{"key":"2_CR1","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-46312-4","volume-title":"Principles of fluorescence spectroscopy","author":"JR Lakowicz","year":"2006","unstructured":"Lakowicz JR (2006) Principles of fluorescence spectroscopy, 3rd edn. Springer, Heidelberg","edition":"3"},{"key":"2_CR2","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1002\/ejic.200800332","volume":"2008","author":"LJ Charbonniere","year":"2008","unstructured":"Charbonniere LJ, Hildebrandt N (2008) Lanthanide complexes and quantum dots: a bright wedding for resonance energy transfer. Eur J Inorg Chem 2008:3241\u20133251","journal-title":"Eur J Inorg Chem"},{"issue":"1","key":"2_CR3","doi-asserted-by":"crossref","first-page":"016007-1","DOI":"10.1117\/1.JBO.17.1.016007","volume":"17","author":"NA Hosny","year":"2012","unstructured":"Hosny NA, Lee DA, Knight MM (2012) Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. J Biomed Opt 17(1):016007-1\u2013016007-12","journal-title":"J Biomed Opt"},{"key":"2_CR4","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.1021\/nn200807g","volume":"5","author":"A Fercher","year":"2011","unstructured":"Fercher A, Borisov SM, Zhdanov AV et al (2011) Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles. ACS Nano 5:5499\u20135508","journal-title":"ACS Nano"},{"key":"2_CR5","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1021\/am9001698","volume":"1","author":"AY Lebedev","year":"2009","unstructured":"Lebedev AY, Cheprakov AV, Sakadzic S et al (2009) Dendritic phosphorescent probes for oxygen imaging in biological systems. Appl Mater Interfaces 1:1292\u20131304","journal-title":"Appl Mater Interfaces"},{"key":"2_CR6","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nmeth.1490","volume":"7","author":"S Sakad\u017eic","year":"2010","unstructured":"Sakad\u017eic S, Roussakis E, Yaseen MA et al (2010) Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods 7:755\u2013759","journal-title":"Nat Methods"},{"key":"2_CR7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF02764572","volume":"7","author":"HC Gerritsen","year":"1997","unstructured":"Gerritsen HC, Sanders R, Draaijer A et al (1997) Fluorescence lifetime imaging of oxygen in cells. J Fluoresc 7:11\u201316","journal-title":"J Fluoresc"},{"key":"2_CR8","doi-asserted-by":"crossref","unstructured":"Papkovsky D, Zhdanov AV, Fercher A et al (2012) Phosphorescent oxygen-sensitive probes. Springer","DOI":"10.1007\/978-3-0348-0525-4"},{"key":"2_CR9","doi-asserted-by":"crossref","first-page":"8700","DOI":"10.1039\/c3cs60131e","volume":"42","author":"DB Papkovsky","year":"2013","unstructured":"Papkovsky DB, Dmitriev RI (2013) Biological detection by optical oxygen sensing. Chem Soc Rev 42:8700\u20138732","journal-title":"Chem Soc Rev"},{"key":"2_CR10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1152\/jappl.2001.91.1.321","volume":"91","author":"M Shibata","year":"2001","unstructured":"Shibata M, Ichioka S, Ando J, Kamiya A (2001) Microvascular and interstitial PO2 measurement in rat skeletal muscle by phosphorescence quenching. J Appl Physiol 91:321\u2013327","journal-title":"J Appl Physiol"},{"key":"2_CR11","doi-asserted-by":"crossref","first-page":"02401-1","DOI":"10.1117\/1.2717503","volume":"12","author":"MC Skala","year":"2007","unstructured":"Skala MC, Riching KM, Bird DK et al (2007) In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia. J Biomed Opt 12:02401-1\u201302401-10","journal-title":"J Biomed Opt"},{"key":"2_CR12","doi-asserted-by":"crossref","DOI":"10.1007\/3-540-28882-1","volume-title":"Advanced time-correlated single-photon counting techniques","author":"W Becker","year":"2005","unstructured":"Becker W (2005) Advanced time-correlated single-photon counting techniques. Springer, Berlin, Heidelberg, New York"},{"key":"2_CR13","volume-title":"The bh TCSPC handbook","author":"W Becker","year":"2015","unstructured":"Becker W (2015) The bh TCSPC handbook, 6th edn. Becker & Hickl GmbH, Berlin. Available from: www.becker-hickl.com","edition":"6"},{"key":"2_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-14929-5","volume-title":"Advanced time-correlated single photon counting applications","author":"W Becker","year":"2015","unstructured":"Becker W (2015) Introduction to multi-dimensional TCSPC. In: Becker W (ed) Advanced time-correlated single photon counting applications. Springer, Berlin, Heidelberg, New York, pp 1\u201363"},{"key":"2_CR15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-319-14929-5_2","volume-title":"Advanced time-correlated single photon counting applications","author":"W Becker","year":"2015","unstructured":"Becker W, Shcheslavskiy V, Studier H (2015) TCSPC FLIM with different optical scanning techniques. In: Becker W (ed) Advanced time-correlated single photon counting applications. Springer, Berlin, Heidelberg, New York, pp 65\u2013117"},{"key":"2_CR16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.medpho.2015.02.001","volume":"27","author":"W Becker","year":"2015","unstructured":"Becker W (2015) Fluorescence lifetime imaging by multi-dimensional time correlated single photon counting. Med Photon 27:41\u201361","journal-title":"Med Photon"},{"key":"2_CR17","doi-asserted-by":"crossref","first-page":"89481K","DOI":"10.1117\/12.2039454","volume":"8948","author":"H Studier","year":"2014","unstructured":"Studier H, Becker W (2014) Megapixel FLIM. Proc SPIE 8948:89481K","journal-title":"Proc SPIE"},{"key":"2_CR18","doi-asserted-by":"crossref","first-page":"790320","DOI":"10.1117\/12.875204","volume":"7903","author":"W Becker","year":"2011","unstructured":"Becker W, Su B, Bergmann A et al (2011) Simultaneous fluorescence and phosphorescence lifetime imaging. Proc SPIE 7903:790320","journal-title":"Proc SPIE"},{"key":"2_CR19","first-page":"203","volume-title":"Fluorecence lifetime spectroscopy and imaging. Principles and applications in biomedical diagnostics","author":"W Becker","year":"2015","unstructured":"Becker W (2015) Fluorescence lifetime imaging techniques: time-correlated single-photon counting. In: Marcu L, French PMW, Elson DS (eds) Fluorecence lifetime spectroscopy and imaging. Principles and applications in biomedical diagnostics. CRC Press, Taylor & Francis Group, Boca Raton, London, New York, pp 203\u2013232"},{"key":"2_CR20","doi-asserted-by":"crossref","first-page":"091111-1","DOI":"10.1063\/1.4943265","volume":"108","author":"VI Shcheslavskiy","year":"2016","unstructured":"Shcheslavskiy VI, Neubauer A, Bukowiecki R et al (2016) Combined fluorescence and phosphorescence lifetime imaging. Appl Phys Lett 108:091111-1\u2013091111-5","journal-title":"Appl Phys Lett"},{"key":"2_CR21","unstructured":"Becker & Hickl GmbH (2015) DCS-120 confocal scanning FLIM systems. In: User handbook, 6th edn. Available from: www.becker-hickl.com"},{"key":"2_CR22","unstructured":"Sutter instrument, Movable objective microscope. www.sutter.com\/microscopes"},{"issue":"3","key":"2_CR23","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/ac404072z","volume":"86","author":"C Toncelli","year":"2014","unstructured":"Toncelli C, Arzhakova OV, Dolgova A et al (2014) Oxygen-sensitive phosphorescent nanomaterials produced from high density polyethylene films by local solvent-crazing. Anal Chem 86(3):1917\u20131923","journal-title":"Anal Chem"},{"key":"2_CR24","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1039\/C3BM60272A","volume":"2","author":"RI Dmitriev","year":"2014","unstructured":"Dmitriev RI, Kondrashina AV, Koren K et al (2014) Small molecule phosphorescent probes for O2 imaging in 3D tissue models. Biomater Sci 2:853\u2013866","journal-title":"Biomater Sci"},{"key":"2_CR25","doi-asserted-by":"crossref","first-page":"9307","DOI":"10.1016\/j.biomaterials.2013.08.065","volume":"34","author":"RI Dmitriev","year":"2013","unstructured":"Dmitriev RI, Zhdanov AV, Nolan YM, Papkovsky DB (2013) Imaging of neurosphere oxygenation with phosphorescent probes. Biomaterials 34:9307\u20139317","journal-title":"Biomaterials"},{"issue":"8","key":"2_CR26","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/jbio.201500297","volume":"9","author":"S Kalinina","year":"2016","unstructured":"Kalinina S, Shcheslavskiy V, Becker W et al (2016) Correlative NAD(P)H-FLIM and oxygen sensing-PLIM for metabolic mapping. J Biophotonics 9(8):800\u2013811","journal-title":"J Biophotonics"},{"key":"2_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep10657","volume":"5","author":"H Kurokawa","year":"2015","unstructured":"Kurokawa H, Ito H, Inoue M et al (2015) High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime. Sci Rep 5:1\u201313","journal-title":"Sci Rep"},{"key":"2_CR28","doi-asserted-by":"crossref","first-page":"C501","DOI":"10.1152\/ajpcell.00121.2015","volume":"309","author":"AV Zhdanov","year":"2015","unstructured":"Zhdanov AV, Golubeva AV, Okkelman IA et al (2015) Imaging of oxygen gradients in giant umbrella cells: an ex vivo PLIM study. Am J Phys Cell Phys 309:C501\u2013C509","journal-title":"Am J Phys Cell Phys"},{"issue":"4","key":"2_CR29","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1364\/OL.42.000731","volume":"42","author":"M Lukina","year":"2017","unstructured":"Lukina M, Orlova A, Shirmanova M et al (2017) Interrogation of metabolic and oxygen states of tumors with fiber-based luminescence lifetime spectroscopy. Opt Lett 42(4):731\u2013734","journal-title":"Opt Lett"},{"key":"2_CR30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-3-319-14929-5_6","volume-title":"Advanced time-correlated single photon counting applications","author":"J Jenkins","year":"2015","unstructured":"Jenkins J, Dmitriev RI, Papkovsky DB (2015) Imaging cell and tissue O2 by TCSPC-PLIM. In: Becker W (ed) Advanced time-correlated single photon counting applications. Springer, Berlin, Heidelberg, New York, pp 225\u2013247"},{"key":"2_CR31","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/978-3-319-14929-5_15","volume-title":"Advanced time-correlated single photon counting applications","author":"WY Sanchez","year":"2015","unstructured":"Sanchez WY, Pastore M, Haridass I et al (2015) Fluorescence lifetime imaging of the skin. In: Becker W (ed) Advanced time-correlated single photon counting applications. Springer, Berlin, Heidelberg, New York, pp 457\u2013508"},{"key":"2_CR32","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1039\/C3SC51875B","volume":"5","author":"E Baggaley","year":"2014","unstructured":"Baggaley E, Botchway SW, Haycock JW et al (2014) Long-lived metal complexes open up microsecond lifetime imaging microscopy under multiphoton excitation: from FLIM to PLIM and beyond. Chem Sci 5:879\u2013886","journal-title":"Chem Sci"},{"key":"2_CR33","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1002\/anie.201309427","volume":"53","author":"E Baggaley","year":"2014","unstructured":"Baggaley E, Gill MR, Green NH et al (2014) Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA. Angew Chem Int Ed Eng 53:3367\u20133371","journal-title":"Angew Chem Int Ed Eng"}],"container-title":["Advances in Experimental Medicine and Biology","Multi-Parametric Live Cell Microscopy of 3D Tissue Models"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-67358-5_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T07:15:26Z","timestamp":1570259726000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-67358-5_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319673578","9783319673585"],"references-count":33,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-67358-5_2","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}