{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:58:37Z","timestamp":1775998717859,"version":"3.50.1"},"publisher-location":"Cham","reference-count":14,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319673578","type":"print"},{"value":"9783319673585","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-67358-5_9","type":"book-chapter","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T05:34:37Z","timestamp":1509082477000},"page":"135-141","source":"Crossref","is-referenced-by-count":9,"title":["Quantitative Imaging of Ca2+ by 3D\u2013FLIM in Live Tissues"],"prefix":"10.1007","author":[{"given":"Asylkhan","family":"Rakymzhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Radbruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca A.","family":"Niesner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,28]]},"reference":[{"issue":"2","key":"9_CR1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nmeth1009","volume":"4","author":"N Heim","year":"2007","unstructured":"Heim N, Garaschuk O, Friedrich MW, Mank M, Milos RI, Kovalchuk Y, Konnerth A, Griesbeck O (2007) Improved calcium imaging in transgenic mice expressing a troponin C-based biosensor. Nat Methods 4(2):127\u2013129","journal-title":"Nat Methods"},{"issue":"4","key":"9_CR2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bpj.2009.10.035","volume":"98","author":"J Herz","year":"2010","unstructured":"Herz J, Siffrin V, Hauser AE, Brandt AU, Leuenberger T, Radbruch H, Zipp F, Niesner RA (2010) Expanding two-photon intravital microscopy to the infrared by means of optical parametric oscillator. Biophys J 98(4):715\u2013723","journal-title":"Biophys J"},{"key":"9_CR3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnmol.2014.00088","volume":"7","author":"T Rose","year":"2014","unstructured":"Rose T, Goltstein PM, Portugues R, Griesbeck O (2014) Putting a finishing touch on GECIs. Front Mol Neurosci 7:88","journal-title":"Front Mol Neurosci"},{"key":"9_CR4","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nbt896","volume":"21","author":"EA Jares-Erijman","year":"2003","unstructured":"Jares-Erijman EA, Jovin TM (2003) FRET imaging. Nat Biotechnol 21:1387\u20131395","journal-title":"Nat Biotechnol"},{"issue":"1","key":"9_CR5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1046-2023(02)00283-9","volume":"29","author":"M Elangovan","year":"2003","unstructured":"Elangovan M, Wallrabe H, Chen Y, Day RN, Barroso M, Periasamy A (2003) Characterization of one- and two-photon excitation fluorescence resonance energy transfer microscopy. Methods 29(1):58\u201373","journal-title":"Methods"},{"issue":"11","key":"9_CR6","doi-asserted-by":"crossref","first-page":"C724","DOI":"10.1152\/ajpcell.00182.2015","volume":"309","author":"W Tao","year":"2015","unstructured":"Tao W, Rubart M, Ryan J, Xiao X, Qiao C, Hato T, Davidson MW, Dunn KW, Day RN (2015) A practical method for monitoring FRET-based biosensors in living animals using two-photon microscopy. Am J Phys Cell Physiol 309(11):C724\u2013C735","journal-title":"Am J Phys Cell Physiol"},{"issue":"11","key":"9_CR7","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1038\/nprot.2016.121","volume":"11","author":"RN Day","year":"2016","unstructured":"Day RN, Tao W, Dunn KW (2016) A simple approach for measuring FRET in fluorescent biosensors using two-photon microscopy. Nat Protoc 11(11):2066\u20132080","journal-title":"Nat Protoc"},{"issue":"5","key":"9_CR8","doi-asserted-by":"crossref","first-page":"11713","DOI":"10.3390\/ijms160511713","volume":"16","author":"H Radbruch","year":"2015","unstructured":"Radbruch H, Bremer D, Mothes R, G\u00fcnther R, Rinnenthal JL, Pohlan J, Ulbricht C, Hauser AE, Niesner R (2015) Intravital FRET: probing cellular and tissue function in vivo. Int J Mol Sci 16(5):11713\u201311727","journal-title":"Int J Mol Sci"},{"issue":"18","key":"9_CR9","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1364\/OL.34.002772","volume":"34","author":"J McGinty","year":"2009","unstructured":"McGinty J, Soloviev VY, Tahir KB, Laine R, Stuckey DW, Hajnal JV, Sardini A, French PM, Arridge SR (2009) Three-dimensional imaging of F\u00f6rster resonance energy transfer in heterogeneous turbid media by tomographic fluorescent lifetime imaging. Opt Lett 34(18):2772\u20132774","journal-title":"Opt Lett"},{"issue":"6","key":"9_CR10","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00401-015-1497-x","volume":"130","author":"AA Mossakowski","year":"2015","unstructured":"Mossakowski AA, Pohlan J, Bremer D, Lindquist R, Millward JM, Bock M, Pollok K, Mothes R, Viohl L, Radbruch M, Gerhard J, Bellmann-Strobl J, Behrens J, Infante-Duarte C, M\u00e4hler A, Boschmann M, Rinnenthal JL, F\u00fcchtemeier M, Herz J, Pache FC, Bardua M, Priller J, Hauser AE, Paul F, Niesner R, Radbruch H (2015) Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation. Acta Neuropathol 130(6):799\u2013814","journal-title":"Acta Neuropathol"},{"key":"9_CR11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fimmu.2016.00092","volume":"7","author":"H Radbruch","year":"2016","unstructured":"Radbruch H, Bremer D, Guenther R, Cseresnyes Z, Lindquist R, Hauser AE, Niesner R (2016) Ongoing oxidative stress causes subclinical neuronal dysfunction in the recovery phase of EAE. Front Immunol 7:92","journal-title":"Front Immunol"},{"issue":"4","key":"9_CR12","doi-asserted-by":"crossref","first-page":"e60100","DOI":"10.1371\/journal.pone.0060100","volume":"8","author":"JL Rinnenthal","year":"2013","unstructured":"Rinnenthal JL, B\u00f6rnchen C, Radbruch H, Andresen V, Mossakowski A, Siffrin V, Seelemann T, Spiecker H, Moll I, Herz J, Hauser AE, Zipp F, Behne MJ, Niesner R (2013) Parallelized TCSPC for dynamic intravital fluorescence lifetime imaging: quantifying neuronal dysfunction in neuroinflammation. PLoS One 8(4):e60100","journal-title":"PLoS One"},{"key":"9_CR13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fimmu.2016.00642","volume":"7","author":"D Bremer","year":"2016","unstructured":"Bremer D, Pache F, G\u00fcnther R, Hornow J, Andresen V, Leben R, Mothes R, Zimmermann H, Brandt AU, Paul F, Hauser AE, Radbruch H, Niesner R (2016) Longitudinal intravital imaging of the retina reveals long-term dynamics of immune infiltration and its effects on the glial network in experimental autoimmune uveoretinitis, without evident signs of neuronal dysfunction in the ganglion cell layer. Front Immunol 7:642","journal-title":"Front Immunol"},{"issue":"3","key":"9_CR14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.immuni.2010.08.018","volume":"33","author":"V Siffrin","year":"2010","unstructured":"Siffrin V, Radbruch H, Glumm R, Niesner R, Paterka M, Herz J, Leuenberger T, Lehmann SM, Luenstedt S, Rinnenthal JL, Laube G, Luche H, Lehnardt S, Fehling HJ, Griesbeck O, Zipp F (2010) In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis. Immunity 33(3):424\u2013436","journal-title":"Immunity"}],"container-title":["Advances in Experimental Medicine and Biology","Multi-Parametric Live Cell Microscopy of 3D Tissue Models"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-67358-5_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T03:15:43Z","timestamp":1570245343000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-67358-5_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319673578","9783319673585"],"references-count":14,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-67358-5_9","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}