{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:56:32Z","timestamp":1792032992711,"version":"4.4.0"},"publisher-location":"Cham","reference-count":108,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319752402","type":"print"},{"value":"9783319752419","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-75241-9_10","type":"book-chapter","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T04:13:07Z","timestamp":1520914387000},"page":"243-268","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Beginning to Understand the Role of the Type IV Secretion System Effector Proteins in Coxiella burnetii Pathogenesis"],"prefix":"10.1007","author":[{"given":"Anja","family":"L\u00fchrmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley J.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bonazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"10_CR1","doi-asserted-by":"crossref","unstructured":"Akporiaye ET, Rowatt JD, Aragon AA, Baca OG (1983) Lysosomal response of a murine macrophage-like cell line persistently infected with Coxiella burnetii. Infect Immun 40(3):1155\u20131162. PMCID: PMC348171","DOI":"10.1128\/IAI.40.3.1155-1162.1983"},{"issue":"4","key":"10_CR2","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1128\/MMBR.00023-09","volume":"73","author":"C. E. Alvarez-Martinez","year":"2009","unstructured":"Alvarez-Martinez CE, Christie PJ (2009) Biological diversity of prokaryotic type IV secretion systems. Microbiol Mol Biol Rev 73(4):775\u2013808. https:\/\/doi.org\/10.1128\/mmbr.00023-09","journal-title":"Microbiology and Molecular Biology Reviews"},{"issue":"3\u20134","key":"10_CR3","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.vetmic.2009.07.016","volume":"140","author":"E Angelakis","year":"2010","unstructured":"Angelakis E, Raoult D (2010) Q Fever Vet Microbiol 140(3\u20134):297\u2013309. https:\/\/doi.org\/10.1016\/j.vetmic.2009.07.016","journal-title":"Q Fever Vet Microbiol"},{"issue":"2","key":"10_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.mib.2006.02.008","volume":"9","author":"S Backert","year":"2006","unstructured":"Backert S, Meyer TF (2006) Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin Microbiol 9(2):207\u2013217. https:\/\/doi.org\/10.1016\/j.mib.2006.02.008","journal-title":"Curr Opin Microbiol"},{"issue":"7","key":"10_CR6","doi-asserted-by":"publisher","first-page":"e00218","DOI":"10.1128\/IAI.00218-17","volume":"85","author":"Reginaldo G. Bastos","year":"2017","unstructured":"Bastos RG, Howard ZP, Hiroyasu A, Goodman AG (2017) Host and Bacterial Factors Control Susceptibility of Drosophila melanogaster to Coxiella burnetii Infection. Infect Immun 85(7). https:\/\/doi.org\/10.1128\/iai.00218-17","journal-title":"Infection and Immunity"},{"issue":"2","key":"10_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1177\/1753425916679255","volume":"23","author":"JM Battisti","year":"2017","unstructured":"Battisti JM, Watson LA, Naung MT, Drobish AM, Voronina E, Minnick MF (2017) Analysis of the Caenorhabditis elegans innate immune response to Coxiella burnetii. Innate Immun 23(2):111\u2013127. https:\/\/doi.org\/10.1177\/1753425916679255","journal-title":"Innate Immun"},{"issue":"5","key":"10_CR8","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1128\/JB.01580-08","volume":"191","author":"PA Beare","year":"2009","unstructured":"Beare PA, Howe D, Cockrell DC, Omsland A, Hansen B, Heinzen RA (2009) Characterization of a Coxiella burnetii ftsZ mutant generated by Himar1 transposon mutagenesis. J Bacteriol 191(5):1369\u20131381. https:\/\/doi.org\/10.1128\/JB.01580-08","journal-title":"J Bacteriol"},{"issue":"4","key":"10_CR9","doi-asserted-by":"publisher","first-page":"e00175","DOI":"10.1128\/mBio.00175-11","volume":"2","author":"PA Beare","year":"2011","unstructured":"Beare PA, Gilk SD, Larson CL, Hill J, Stead CM, Omsland A, Cockrell DC, Howe D, Voth DE, Heinzen RA (2011) Dot\/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages. MBio 2(4):e00175\u201300111. https:\/\/doi.org\/10.1128\/mBio.00175-11","journal-title":"MBio"},{"key":"10_CR10","first-page":"98","volume":"69","author":"AS Benenson","year":"1956","unstructured":"Benenson AS, Tigertt WD (1956) Studies on Q fever in man. Trans Assoc Am Physicians 69:98\u2013104 PMID: 13380951","journal-title":"Trans Assoc Am Physicians"},{"issue":"2","key":"10_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","volume":"7","author":"T Bergsbaken","year":"2009","unstructured":"Bergsbaken T, Fink SL, Cookson BT (2009) Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 7(2):99\u2013109. https:\/\/doi.org\/10.1038\/nrmicro2070","journal-title":"Nat Rev Microbiol"},{"issue":"10","key":"10_CR12","doi-asserted-by":"publisher","first-page":"5816","DOI":"10.1128\/IAI.70.10.5816-5821.2002","volume":"70","author":"W Beron","year":"2002","unstructured":"Beron W, Gutierrez MG, Rabinovitch M, Colombo MI (2002) Coxiella burnetii localizes in a Rab7-labeled compartment with autophagic characteristics. Infect Immun 70(10):5816\u20135821. https:\/\/doi.org\/10.1128\/IAI.70.10.5816-5821.2002","journal-title":"Infect Immun"},{"issue":"4","key":"10_CR13","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1080\/21505594.2016.1139280","volume":"7","author":"S Bisle","year":"2016","unstructured":"Bisle S, Klingenbeck L, Borges V, Sobotta K, Schulze-Luehrmann J, Menge C, Heydel C, Gomes JP, L\u00fchrmann A (2016) The inhibition of the apoptosis pathway by the Coxiella burnetii effector protein CaeA requires the EK repetition motif, but is independent of survivin. Virulence 7(4):400\u2013412. https:\/\/doi.org\/10.1080\/21505594.2016.1139280","journal-title":"Virulence"},{"issue":"4","key":"10_CR14","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1128\/IAI.01536-15","volume":"84","author":"WP Bradley","year":"2016","unstructured":"Bradley WP, Boyer MA, Nguyen HT, Birdwell LD, Yu J, Ribeiro JM, Weiss SR, Zamboni DS, Roy CR, Shin S (2016) Primary role for toll-like receptor-driven tumor necrosis factor rather than cytosolic immune detection in restricting Coxiella burnetii phase II replication within mouse macrophages. Infect Immun 84(4):998\u20131015. https:\/\/doi.org\/10.1128\/IAI.01536-15","journal-title":"Infect Immun"},{"key":"10_CR15","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1186\/1471-2334-13-488","volume":"13","author":"RJ Brooke","year":"2013","unstructured":"Brooke RJ, Kretzschmar ME, Mutters NT, Teunis PF (2013) Human dose response relation for airborne exposure to Coxiella burnetii. BMC Infect Dis 13:488. https:\/\/doi.org\/10.1186\/1471-2334-13-488","journal-title":"BMC Infect Dis"},{"issue":"2","key":"10_CR16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1139\/m71-025","volume":"17","author":"PR Burton","year":"1971","unstructured":"Burton PR, Kordova N, Paretsky D (1971) Electron microscopic studies of the rickettsia Coxiella burnetii: entry, lysosomal response, and fate of rickettsial DNA in L-cells. Can J Microbiol 17(2):143\u2013150 PMID: 4100953","journal-title":"Can J Microbiol"},{"key":"10_CR17","doi-asserted-by":"crossref","unstructured":"Burton PR, Stueckemann J, Welsh RM, Paretsky D (1978) Some ultrastructural effects of persistent infections by the rickettsia Coxiella burnetii in mouse L cells and green monkey kidney (Vero) cells. Infect Immun 21(2):556\u2013566. PMCID: PMC422031","DOI":"10.1128\/IAI.21.2.556-566.1978"},{"issue":"5","key":"10_CR18","doi-asserted-by":"publisher","first-page":"e1002056","DOI":"10.1371\/journal.ppat.1002056","volume":"7","author":"KL Carey","year":"2011","unstructured":"Carey KL, Newton HJ, L\u00fchrmann A, Roy CR (2011) The Coxiella burnetii Dot\/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication. PLoS Pathog 7(5):e1002056. https:\/\/doi.org\/10.1371\/journal.ppat.1002056","journal-title":"PLoS Pathog"},{"key":"10_CR19","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1146\/annurev-biochem-062911-102821","volume":"84","author":"V Chandran Darbari","year":"2015","unstructured":"Chandran Darbari V, Waksman G (2015) Structural biology of bacterial type IV secretion systems. Annu Rev Biochem 84:603\u2013629. https:\/\/doi.org\/10.1146\/annurev-biochem-062911-102821","journal-title":"Annu Rev Biochem"},{"issue":"50","key":"10_CR20","doi-asserted-by":"publisher","first-page":"21755","DOI":"10.1073\/pnas.1010485107","volume":"107","author":"C Chen","year":"2010","unstructured":"Chen C, Banga S, Mertens K, Weber MM, Gorbaslieva I, Tan Y, Luo ZQ, Samuel JE (2010) Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii. Proc Natl Acad Sci U S A 107(50):21755\u201321760. https:\/\/doi.org\/10.1073\/pnas.1010485107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"10_CR21","doi-asserted-by":"publisher","first-page":"7344","DOI":"10.1128\/JB.186.21.7344-7352.2004","volume":"186","author":"SA Coleman","year":"2004","unstructured":"Coleman SA, Fischer ER, Howe D, Mead DJ, Heinzen RA (2004) Temporal analysis of Coxiella burnetii morphological differentiation. J Bacteriol 186(21):7344\u20137352. https:\/\/doi.org\/10.1128\/JB.186.21.7344-7352.2004","journal-title":"J Bacteriol"},{"issue":"9","key":"10_CR23","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nrc883","volume":"2","author":"S Cory","year":"2002","unstructured":"Cory S, Adams JM (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2(9):647\u2013656. https:\/\/doi.org\/10.1038\/nrc883","journal-title":"Nat Rev Cancer"},{"key":"10_CR24","doi-asserted-by":"publisher","first-page":"10205","DOI":"10.1038\/ncomms10205","volume":"6","author":"LD Cunha","year":"2015","unstructured":"Cunha LD, Ribeiro JM, Fernandes TD, Massis LM, Khoo CA, Moffatt JH, Newton HJ, Roy CR, Zamboni DS (2015) Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA. Nat Commun 6:10205. https:\/\/doi.org\/10.1038\/ncomms10205","journal-title":"Nat Commun"},{"issue":"4","key":"10_CR25","doi-asserted-by":"publisher","first-page":"e01534","DOI":"10.1128\/mBio.01534-14","volume":"5","author":"DM Czyz","year":"2014","unstructured":"Czyz DM, Potluri LP, Jain-Gupta N, Riley SP, Martinez JJ, Steck TL, Crosson S, Shuman HA, Gabay JE (2014) Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens. MBio 5(4):e01534\u201301514. https:\/\/doi.org\/10.1128\/mBio.01534-14","journal-title":"MBio"},{"issue":"10","key":"10_CR26","doi-asserted-by":"publisher","first-page":"5673","DOI":"10.1128\/IAI.68.10.5673-5678.2000","volume":"68","author":"J. Dellacasagrande","year":"2000","unstructured":"Dellacasagrande J, Ghigo E, Hammami SM, Toman R, Raoult D, Capo C, Mege JL (2000) Alpha(v)beta(3) integrin and bacterial lipopolysaccharide are involved in Coxiella burnetii-stimulated production of tumor necrosis factor by human monocytes. Infect Immun 68(10):5673\u20135678. PMCID: PMC101522","journal-title":"Infection and Immunity"},{"key":"10_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-1-4614-0204-6_12","volume":"719","author":"CE Delsing","year":"2011","unstructured":"Delsing CE, Warris A, Bleeker-Rovers CP (2011) Q fever: still more queries than answers. Adv Exp Med Biol 719:133\u2013143. https:\/\/doi.org\/10.1007\/978-1-4614-0204-6_12","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"10_CR28","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1128\/IAI.01204-13","volume":"82","author":"RA Eckart","year":"2014","unstructured":"Eckart RA, Bisle S, Schulze-Luehrmann J, Wittmann I, Jantsch J, Schmid B, Berens C, L\u00fchrmann A (2014) Antiapoptotic activity of Coxiella burnetii effector protein AnkG is controlled by p32-dependent trafficking. Infect Immun 82(7):2763\u20132771. https:\/\/doi.org\/10.1128\/IAI.01204-13","journal-title":"Infect Immun"},{"issue":"6662","key":"10_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/34112","volume":"391","author":"M Enari","year":"1998","unstructured":"Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S (1998) A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nat 391(6662):43\u201350. https:\/\/doi.org\/10.1038\/34112","journal-title":"Nat"},{"issue":"5","key":"10_CR31","doi-asserted-by":"publisher","first-page":"e01046","DOI":"10.1128\/IAI.01046-16","volume":"85","author":"Laura F. Fielden","year":"2017","unstructured":"Fielden LF, Moffatt JH, Kang Y, Baker MJ, Khoo CA, Roy CR, Stojanovski D, Newton HJ (2017) A farnesylated Coxiella burnetii effector forms a multimeric complex at the mitochondrial outer membrane during infection. Infect Immun 85(5): https:\/\/doi.org\/10.1128\/iai.01046-16","journal-title":"Infection and Immunity"},{"key":"10_CR32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1146\/annurev-pathol-011811-132445","volume":"7","author":"RS Flannagan","year":"2012","unstructured":"Flannagan RS, Jaumouille V, Grinstein S (2012) The cell biology of phagocytosis. Annu Rev Pathol 7:61\u201398. https:\/\/doi.org\/10.1146\/annurev-pathol-011811-132445","journal-title":"Annu Rev Pathol"},{"key":"10_CR33","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.mib.2017.03.001","volume":"35","author":"A Friedrich","year":"2017","unstructured":"Friedrich A, Pechstein J, Berens C, L\u00fchrmann A (2017) Modulation of host cell apoptotic pathways by intracellular pathogens. Curr Opin Microbiol 35:88\u201399. https:\/\/doi.org\/10.1016\/j.mib.2017.03.001","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"10_CR34","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1042\/BST20140290","volume":"43","author":"M Gallon","year":"2015","unstructured":"Gallon M, Cullen PJ (2015) Retromer and sorting nexins in endosomal sorting. Biochem Soc Trans 43(1):33\u201347. https:\/\/doi.org\/10.1042\/BST20140290","journal-title":"Biochem Soc Trans"},{"issue":"11","key":"10_CR35","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/15200","volume":"5","author":"S Gallucci","year":"1999","unstructured":"Gallucci S, Lolkema M, Matzinger P (1999) Natural adjuvants: endogenous activators of dendritic cells. Nat Med 5(11):1249\u20131255. https:\/\/doi.org\/10.1038\/15200","journal-title":"Nat Med"},{"key":"10_CR36","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643598","author":"D Ghosal","year":"2017","unstructured":"Ghosal D, Chang YW, Jeong KC, Vogel JP, Jensen GJ (2017) In situ structure of the Legionella Dot\/Icm type IV secretion system by electron cryotomography. EMBO Rep. https:\/\/doi.org\/10.15252\/embr.201643598","journal-title":"EMBO Rep"},{"key":"10_CR37","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/978-94-007-4315-1_10","volume":"984","author":"SD Gilk","year":"2012","unstructured":"Gilk SD (2012) Role of lipids in Coxiella burnetii infection. Adv Exp Med Biol 984:199\u2013213. https:\/\/doi.org\/10.1007\/978-94-007-4315-1_10","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10_CR38","doi-asserted-by":"publisher","first-page":"e1003107","DOI":"10.1371\/journal.ppat.1003107","volume":"9","author":"SD Gilk","year":"2013","unstructured":"Gilk SD, Cockrell DC, Luterbach C, Hansen B, Knodler LA, Ibarra JA, Steele-Mortimer O, Heinzen RA (2013) Bacterial colonization of host cells in the absence of cholesterol. PLoS Pathog 9(1):e1003107. https:\/\/doi.org\/10.1371\/journal.ppat.1003107","journal-title":"PLoS Pathog"},{"issue":"6","key":"10_CR39","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1111\/cmi.12096","volume":"15","author":"JG Graham","year":"2013","unstructured":"Graham JG, MacDonald LJ, Hussain SK, Sharma UM, Kurten RC, Voth DE (2013) Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages. Cell Microbiol 15(6):1012\u20131025. https:\/\/doi.org\/10.1111\/cmi.12096","journal-title":"Cell Microbiol"},{"issue":"5","key":"10_CR40","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1128\/IAI.00012-16","volume":"84","author":"JG Graham","year":"2016","unstructured":"Graham JG, Winchell CG, Kurten RC, Voth DE (2016) Development of an Ex Vivo tissue platform to study the human lung response to Coxiella burnetii. Infect Immun 84(5):1438\u20131445. https:\/\/doi.org\/10.1128\/IAI.00012-16","journal-title":"Infect Immun"},{"issue":"12","key":"10_CR41","doi-asserted-by":"publisher","first-page":"a006080","DOI":"10.1101\/cshperspect.a006080","volume":"7","author":"Douglas R. Green","year":"2015","unstructured":"Green DR, Llambi F (2015) Cell death signaling. Cold Spring Harb Perspect Biol 7(12). https:\/\/doi.org\/10.1101\/cshperspect.a006080","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"4","key":"10_CR42","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/mmi.13896","volume":"107","author":"Elisabeth Grohmann","year":"2018","unstructured":"Grohmann E, Christie PJ, Waksman G, Backert S (2018) Type IV secretion in Gram-negative and Gram-positive bacteria. Mol Microbiol 107:455\u2013471. https:\/\/doi.org\/10.1111\/mmi.13896","journal-title":"Molecular Microbiology"},{"issue":"7","key":"10_CR44","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1111\/j.1462-5822.2005.00527.x","volume":"7","author":"MG Gutierrez","year":"2005","unstructured":"Gutierrez MG, Vazquez CL, Munafo DB, Zoppino FC, Beron W, Rabinovitch M, Colombo MI (2005) Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles. Cell Microbiol 7(7):981\u2013993. https:\/\/doi.org\/10.1111\/j.1462-5822.2005.00527.x","journal-title":"Cell Microbiol"},{"issue":"5","key":"10_CR45","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1073\/pnas.78.5.3240","volume":"78","author":"T. Hackstadt","year":"1981","unstructured":"Hackstadt T, Williams JC (1981) Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetii. Proc Natl Acad Sci USA 78(5):3240\u20133244. PMCID: PMC319537","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7441","key":"10_CR46","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature11910","volume":"495","author":"M Hamasaki","year":"2013","unstructured":"Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T (2013) Autophagosomes form at ER-mitochondria contact sites. Nat 495(7441):389\u2013393. https:\/\/doi.org\/10.1038\/nature11910","journal-title":"Nat"},{"issue":"8","key":"10_CR47","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1128\/IAI.00510-12","volume":"80","author":"CR Harding","year":"2012","unstructured":"Harding CR, Schroeder GN, Reynolds S, Kosta A, Collins JW, Mousnier A, Frankel G (2012) Legionella pneumophila pathogenesis in the Galleria mellonella infection model. Infect Immun 80(8):2780\u20132790. https:\/\/doi.org\/10.1128\/IAI.00510-12","journal-title":"Infect Immun"},{"key":"10_CR48","doi-asserted-by":"crossref","unstructured":"Heinzen RA, Scidmore MA, Rockey DD, Hackstadt T (1996) Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. Infect Immun 64(3):796\u2013809. PMCID: PMC173840","DOI":"10.1128\/IAI.64.3.796-809.1996"},{"key":"10_CR49","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1196\/annals.1355.020","volume":"1063","author":"D Howe","year":"2005","unstructured":"Howe D, Heinzen RA (2005) Replication of Coxiella burnetii is inhibited in CHO K-1 cells treated with inhibitors of cholesterol metabolism. Ann NY Acad Sci 1063:123\u2013129. https:\/\/doi.org\/10.1196\/annals.1355.020","journal-title":"Ann NY Acad Sci"},{"key":"10_CR50","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/j.1749-6632.2003.tb07426.x","volume":"990","author":"D Howe","year":"2003","unstructured":"Howe D, Melnicakova J, Barak I, Heinzen RA (2003) Fusogenicity of the Coxiella burnetii parasitophorous vacuole. Ann NY Acad Sci 990:556\u2013562. https:\/\/doi.org\/10.1111\/j.1749-6632.2003.tb07426.x","journal-title":"Ann NY Acad Sci"},{"issue":"8","key":"10_CR51","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1128\/IAI.00406-10","volume":"78","author":"D Howe","year":"2010","unstructured":"Howe D, Shannon JG, Winfree S, Dorward DW, Heinzen RA (2010) Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages. Infect Immun 78(8):3465\u20133474. https:\/\/doi.org\/10.1128\/IAI.00406-10","journal-title":"Infect Immun"},{"issue":"6","key":"10_CR52","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.cell.2012.11.001","volume":"151","author":"E Itakura","year":"2012","unstructured":"Itakura E, Kishi-Itakura C, Mizushima N (2012) The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes\/lysosomes. Cell 151(6):1256\u20131269. https:\/\/doi.org\/10.1016\/j.cell.2012.11.001","journal-title":"Cell"},{"issue":"1","key":"10_CR53","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/imr.12287","volume":"265","author":"I Jorgensen","year":"2015","unstructured":"Jorgensen I, Miao EA (2015) Pyroptotic cell death defends against intracellular pathogens. Immunol Rev 265(1):130\u2013142. https:\/\/doi.org\/10.1111\/imr.12287","journal-title":"Immunol Rev"},{"issue":"1","key":"10_CR54","doi-asserted-by":"publisher","first-page":"e12637","DOI":"10.1111\/cmi.12637","volume":"19","author":"Anna V. Justis","year":"2016","unstructured":"Justis AV, Hansen B, Beare PA, King KB, Heinzen RA, Gilk SD (2017) Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L. Cell Microbiol 19(1). https:\/\/doi.org\/10.1111\/cmi.12637","journal-title":"Cellular Microbiology"},{"key":"10_CR55","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nrm4024","volume":"16","author":"J Kaur","year":"2015","unstructured":"Kaur J, Debnath J (2015) Autophagy at the crossroads of catabolism and anabolism. Nat Rev Mol Cell Biol 16:461\u2013472. https:\/\/doi.org\/10.1038\/nrm4024","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"10_CR57","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1586\/14787210.2013.840534","volume":"11","author":"GJ Kersh","year":"2013","unstructured":"Kersh GJ (2013) Antimicrobial therapies for Q fever. Expert Rev Anti Infect Ther 11(11):1207\u20131214. https:\/\/doi.org\/10.1586\/14787210.2013.840534","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"4","key":"10_CR58","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/cmi.12066","volume":"15","author":"L Klingenbeck","year":"2013","unstructured":"Klingenbeck L, Eckart RA, Berens C, L\u00fchrmann A (2013) The Coxiella burnetii type IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level. Cell Microbiol 15(4):675\u2013687. https:\/\/doi.org\/10.1111\/cmi.12066","journal-title":"Cell Microbiol"},{"issue":"5","key":"10_CR59","doi-asserted-by":"publisher","first-page":"e01327","DOI":"10.1128\/mBio.01327-16","volume":"7","author":"Lara J. Kohler","year":"2016","unstructured":"Kohler LJ, Reed Sh C, Sarraf SA, Arteaga DD, Newton HJ, Roy CR (2016) Effector protein Cig2 decreases host tolerance of infection by directing constitutive fusion of autophagosomes with the Coxiella-containing vacuole. MBio 7(4): https:\/\/doi.org\/10.1128\/mbio.01127-16","journal-title":"mBio"},{"issue":"1","key":"10_CR60","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.chom.2010.06.007","volume":"8","author":"M Lamkanfi","year":"2010","unstructured":"Lamkanfi M, Dixit VM (2010) Manipulation of host cell death pathways during microbial infections. Cell Host Microbe 8(1):44\u201354. https:\/\/doi.org\/10.1016\/j.chom.2010.06.007","journal-title":"Cell Host Microbe"},{"issue":"49","key":"10_CR61","doi-asserted-by":"publisher","first-page":"E4770","DOI":"10.1073\/pnas.1309195110","volume":"110","author":"CL Larson","year":"2013","unstructured":"Larson CL, Beare PA, Howe D, Heinzen RA (2013) Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis. Proc Natl Acad Sci USA 110(49):E4770\u20134779. https:\/\/doi.org\/10.1073\/pnas.1309195110","journal-title":"Proc Natl Acad Sci USA"},{"key":"10_CR62","doi-asserted-by":"publisher","first-page":"919","DOI":"10.2217\/fmb-2016-0044","volume":"11","author":"CL Larson","year":"2016","unstructured":"Larson CL, Martinez E, Beare PA, Jeffrey B, Heinzen RA, Bonazzi M (2016) Right on Q: genetics begin to unravel Coxiella burnetii host cell interactions. Future Microbiol 11:919\u2013939. https:\/\/doi.org\/10.2217\/fmb-2016-0044","journal-title":"Future Microbiol"},{"issue":"12","key":"10_CR63","doi-asserted-by":"publisher","first-page":"e1006101","DOI":"10.1371\/journal.ppat.1006101","volume":"12","author":"EA Latomanski","year":"2016","unstructured":"Latomanski EA, Newton P, Khoo CA, Newton HJ (2016) The effector Cig57 hijacks FCHO-mediated vesicular trafficking to facilitate intracellular replication of Coxiella burnetii. PLoS Pathog 12(12):e1006101. https:\/\/doi.org\/10.1371\/journal.ppat.1006101","journal-title":"PLoS Pathog"},{"issue":"11","key":"10_CR65","doi-asserted-by":"publisher","first-page":"5282","DOI":"10.1128\/IAI.00863-07","volume":"75","author":"A L\u00fchrmann","year":"2007","unstructured":"L\u00fchrmann A, Roy CR (2007) Coxiella burnetii inhibits activation of host cell apoptosis through a mechanism that involves preventing cytochrome c release from mitochondria. Infect Immun 75(11):5282\u20135289. https:\/\/doi.org\/10.1128\/IAI.00863-07","journal-title":"Infect Immun"},{"issue":"44","key":"10_CR66","doi-asserted-by":"publisher","first-page":"18997","DOI":"10.1073\/pnas.1004380107","volume":"107","author":"A L\u00fchrmann","year":"2010","unstructured":"L\u00fchrmann A, Nogueira CV, Carey KL, Roy CR (2010) Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci USA 107(44):18997\u201319001. https:\/\/doi.org\/10.1073\/pnas.1004380107","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10_CR67","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s10495-014-1068-y","volume":"20","author":"J Luo","year":"2015","unstructured":"Luo J, Hu J, Zhang Y, Hu Q, Li S (2015) Hijacking of death receptor signaling by bacterial pathogen effectors. Apoptosis 20(2):216\u2013223. https:\/\/doi.org\/10.1007\/s10495-014-1068-y","journal-title":"Apoptosis"},{"issue":"1","key":"10_CR68","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/cmi.12213","volume":"16","author":"LJ Macdonald","year":"2014","unstructured":"Macdonald LJ, Graham JG, Kurten RC, Voth DE (2014) Coxiella burnetii exploits host cAMP-dependent protein kinase signalling to promote macrophage survival. Cell Microbiol 16(1):146\u2013159. https:\/\/doi.org\/10.1111\/cmi.12213","journal-title":"Cell Microbiol"},{"issue":"11","key":"10_CR69","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S1473-3099(03)00804-1","volume":"3","author":"MG Madariaga","year":"2003","unstructured":"Madariaga MG, Rezai K, Trenholme GM, Weinstein RA (2003) Q fever: a biological weapon in your backyard. Lancet Infect Dis 3(11):709\u2013721 PMID: 14592601","journal-title":"Lancet Infect Dis"},{"issue":"10","key":"10_CR70","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1038\/sj.emboj.7601689","volume":"26","author":"MC Maiuri","year":"2007","unstructured":"Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, Tasdemir E, Pierron G, Troulinaki K, Tavernarakis N, Hickman JA, Geneste O, Kroemer G (2007) Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 26(10):2527\u20132539. https:\/\/doi.org\/10.1038\/sj.emboj.7601689","journal-title":"EMBO J"},{"issue":"1","key":"10_CR71","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/imr.12534","volume":"277","author":"SM Man","year":"2017","unstructured":"Man SM, Karki R, Kanneganti TD (2017) Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev 277(1):61\u201375. https:\/\/doi.org\/10.1111\/imr.12534","journal-title":"Immunol Rev"},{"key":"10_CR72","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fcimb.2017.00112","volume":"7","author":"ME Mansilla Pareja","year":"2017","unstructured":"Mansilla Pareja ME, Bongiovanni A, Lafont F, Colombo MI (2017) Alterations of the Coxiella burnetii replicative vacuole membrane integrity and interplay with the autophagy pathway. Front Cell Infect Microbiol 7:112. https:\/\/doi.org\/10.3389\/fcimb.2017.00112","journal-title":"Front Cell Infect Microbiol"},{"issue":"9006","key":"10_CR73","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/S0140-6736(96),91469-5","volume":"347","author":"BP Marmion","year":"1996","unstructured":"Marmion BP, Shannon M, Maddocks I, Storm P, Penttila I (1996) Protracted debility and fatigue after acute Q fever. Lancet 347(9006):977\u2013978. https:\/\/doi.org\/10.1016\/S0140-6736(96),91469-5","journal-title":"Lancet"},{"issue":"3","key":"10_CR74","doi-asserted-by":"publisher","first-page":"e1004013","DOI":"10.1371\/journal.ppat.1004013","volume":"10","author":"E Martinez","year":"2014","unstructured":"Martinez E, Cantet F, Fava L, Norville I, Bonazzi M (2014) Identification of OmpA, a Coxiella burnetii protein involved in host cell invasion, by multi-phenotypic high-content screening. PLoS Pathog 10(3):e1004013. https:\/\/doi.org\/10.1371\/journal.ppat.1004013","journal-title":"PLoS Pathog"},{"issue":"23","key":"10_CR75","doi-asserted-by":"publisher","first-page":"E3260","DOI":"10.1073\/pnas.1522811113","volume":"113","author":"E Martinez","year":"2016","unstructured":"Martinez E, Allombert J, Cantet F, Lakhani A, Yandrapalli N, Neyret A, Norville IH, Favard C, Muriaux D, Bonazzi M (2016) Coxiella burnetii effector CvpB modulates phosphoinositide metabolism for optimal vacuole development. Proc Natl Acad Sci USA 113(23):E3260\u20133269. https:\/\/doi.org\/10.1073\/pnas.1522811113","journal-title":"Proc Natl Acad Sci USA"},{"issue":"14","key":"10_CR76","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1128\/JB.00180-13","volume":"195","author":"P Maturana","year":"2013","unstructured":"Maturana P, Graham JG, Sharma UM, Voth DE (2013) Refining the plasmid-encoded type IV secretion system substrate repertoire of Coxiella burnetii. J Bacteriol 195(14):3269\u20133276. https:\/\/doi.org\/10.1128\/JB.00180-13","journal-title":"J Bacteriol"},{"key":"10_CR77","doi-asserted-by":"crossref","unstructured":"Maurin M, Raoult D (1999) Q fever. Clin Microbiol Rev 12 (4):518\u2013553. PMCID: PMC88923","DOI":"10.1128\/CMR.12.4.518"},{"issue":"5","key":"10_CR78","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1093\/infdis\/166.5.1097","volume":"166","author":"M. Maurin","year":"1992","unstructured":"Maurin M, Benoliel AM, Bongrand P, Raoult D (1992) Phagolysosomal alkalinization and the bactericidal effect of antibiotics: theCoxiella burnetii paradigm. J Infect Dis 166(5):1097\u20131102 PMID: 1402021","journal-title":"Journal of Infectious Diseases"},{"issue":"1","key":"10_CR79","doi-asserted-by":"publisher","first-page":"e00606","DOI":"10.1128\/mBio.00606-12","volume":"4","author":"JA McDonough","year":"2013","unstructured":"McDonough JA, Newton HJ, Klum S, Swiss R, Agaisse H, Roy CR (2013) Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening. MBio 4(1):e00606\u201300612. https:\/\/doi.org\/10.1128\/mBio.00606-12","journal-title":"MBio"},{"key":"10_CR80","doi-asserted-by":"publisher","unstructured":"Millar JA, Beare PA, Moses AS, Martens CA, Heinzen RA, Raghavan R (2017) Whole-genome sequence of Coxiella burnetii nine mile RSA439 (Phase II, Clone 4), a laboratory workhorse strain. Genome Announc 5(23). https:\/\/doi.org\/10.1128\/genomea.00471-17","DOI":"10.1128\/genomea.00471-17"},{"issue":"5","key":"10_CR81","doi-asserted-by":"publisher","first-page":"e0155884","DOI":"10.1371\/journal.pone.0155884","volume":"11","author":"G Morroy","year":"2016","unstructured":"Morroy G, Keijmel SP, Delsing CE, Bleijenberg G, Langendam M, Timen A, Bleeker-Rovers CP (2016) Fatigue following acute Q-Fever: a systematic literature review. PLoS ONE 11(5):e0155884. https:\/\/doi.org\/10.1371\/journal.pone.0155884","journal-title":"PLoS ONE"},{"issue":"1","key":"10_CR82","doi-asserted-by":"publisher","first-page":"e02313","DOI":"10.1128\/mBio.02313-16","volume":"8","author":"Minal Mulye","year":"2017","unstructured":"Mulye M, Samanta D, Winfree S, Heinzen RA, Gilk SD (2017) Elevated cholesterol in the Coxiella burnetii intracellular niche is bacteriolytic. MBio 8(1): https:\/\/doi.org\/10.1128\/mbio.02313-16","journal-title":"mBio"},{"issue":"4","key":"10_CR83","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1177\/0300985812465323","volume":"50","author":"E Myers","year":"2013","unstructured":"Myers E, Ehrhart EJ, Charles B, Spraker T, Gelatt T, Duncan C (2013) Apoptosis in normal and Coxiella burnetii-infected placentas from Alaskan northern fur seals (Callorhinus ursinus). Vet Pathol 50(4):622\u2013625. https:\/\/doi.org\/10.1177\/0300985812465323","journal-title":"Vet Pathol"},{"key":"10_CR84","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3389\/fmicb.2011.00136","volume":"2","author":"H Nagai","year":"2011","unstructured":"Nagai H, Kubori T (2011) Type IVB secretion systems of Legionella and other gram-negative bacteria. Front Microbiol 2:136. https:\/\/doi.org\/10.3389\/fmicb.2011.00136","journal-title":"Front Microbiol"},{"issue":"1","key":"10_CR85","doi-asserted-by":"publisher","first-page":"e54566","DOI":"10.1371\/journal.pone.0054566","volume":"8","author":"HJ Newton","year":"2013","unstructured":"Newton HJ, McDonough JA, Roy CR (2013) Effector protein translocation by the Coxiella burnetii Dot\/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole. PLoS ONE 8(1):e54566. https:\/\/doi.org\/10.1371\/journal.pone.0054566","journal-title":"PLoS ONE"},{"issue":"7","key":"10_CR86","doi-asserted-by":"publisher","first-page":"e1004286","DOI":"10.1371\/journal.ppat.1004286","volume":"10","author":"HJ Newton","year":"2014","unstructured":"Newton HJ, Kohler LJ, McDonough JA, Temoche-Diaz M, Crabill E, Hartland EL, Roy CR (2014) A screen of Coxiella burnetii mutants reveals important roles for Dot\/Icm effectors and host autophagy in vacuole biogenesis. PLoS Pathog 10(7):e1004286. https:\/\/doi.org\/10.1371\/journal.ppat.1004286","journal-title":"PLoS Pathog"},{"key":"10_CR87","doi-asserted-by":"publisher","unstructured":"Newton P, Latomanski EA, Newton HJ (2016) Applying fluorescence resonance energy transfer (FRET) to examine effector translocation efficiency by Coxiella burnetii during siRNA silencing. J Vis Exp (113). https:\/\/doi.org\/10.3791\/54210","DOI":"10.3791\/54210"},{"issue":"Pt 6","key":"10_CR88","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1099\/mic.0.077230-0","volume":"160","author":"IH Norville","year":"2014","unstructured":"Norville IH, Hartley MG, Martinez E, Cantet F, Bonazzi M, Atkins TP (2014) Galleria mellonella as an alternative model of Coxiella burnetii infection. Microbiol 160(Pt 6):1175\u20131181. https:\/\/doi.org\/10.1099\/mic.0.077230-0","journal-title":"Microbiol"},{"issue":"11","key":"10_CR89","doi-asserted-by":"publisher","first-page":"4430","DOI":"10.1073\/pnas.0812074106","volume":"106","author":"A Omsland","year":"2009","unstructured":"Omsland A, Cockrell DC, Howe D, Fischer ER, Virtaneva K, Sturdevant DE, Porcella SF, Heinzen RA (2009) Host cell-free growth of the Q fever bacterium Coxiella burnetii. Proc Natl Acad Sci USA 106(11):4430\u20134434. https:\/\/doi.org\/10.1073\/pnas.0812074106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"10_CR90","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1128\/AEM.02826-10","volume":"77","author":"A Omsland","year":"2011","unstructured":"Omsland A, Beare PA, Hill J, Cockrell DC, Howe D, Hansen B, Samuel JE, Heinzen RA (2011) Isolation from animal tissue and genetic transformation of Coxiella burnetii are facilitated by an improved axenic growth medium. Appl Environ Microbiol 77(11):3720\u20133725. https:\/\/doi.org\/10.1128\/AEM.02826-10","journal-title":"Appl Environ Microbiol"},{"issue":"5883","key":"10_CR91","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1126\/science.1158160","volume":"320","author":"X Pan","year":"2008","unstructured":"Pan X, L\u00fchrmann A, Satoh A, Laskowski-Arce MA, Roy CR (2008) Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Sci 320(5883):1651\u20131654. https:\/\/doi.org\/10.1126\/science.1158160","journal-title":"Sci"},{"issue":"1","key":"10_CR92","doi-asserted-by":"publisher","first-page":"e0148032","DOI":"10.1371\/journal.pone.0148032","volume":"11","author":"M Rodriguez-Escudero","year":"2016","unstructured":"Rodriguez-Escudero M, Cid VJ, Molina M, Schulze-Luehrmann J, L\u00fchrmann A, Rodriguez-Escudero I (2016) Studying Coxiella burnetii type IV substrates in the yeast Saccharomyces cerevisiae: focus on subcellular localization and protein aggregation. PLoS ONE 11(1):e0148032. https:\/\/doi.org\/10.1371\/journal.pone.0148032","journal-title":"PLoS ONE"},{"issue":"6","key":"10_CR93","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nrm830","volume":"3","author":"GS Salvesen","year":"2002","unstructured":"Salvesen GS, Duckett CS (2002) IAP proteins: blocking the road to death\u2019s door. Nat Rev Mol Cell Biol 3(6):401\u2013410. https:\/\/doi.org\/10.1038\/nrm830","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10_CR94","doi-asserted-by":"publisher","unstructured":"Sch\u00e4fer W, Eckart RA, Schmid B, Cagkoylu H, Hof K, Muller YA, Amin B, L\u00fchrmann A (2017) Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p 32 and Importin-alpha1. Cell Microbiol 19(1). https:\/\/doi.org\/10.1111\/cmi.12634","DOI":"10.1111\/cmi.12634"},{"issue":"12","key":"10_CR95","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.1128\/IAI.00694-16","volume":"84","author":"L Schoenlaub","year":"2016","unstructured":"Schoenlaub L, Cherla R, Zhang Y, Zhang G (2016) Coxiella burnetii avirulent nine mile phase II induces caspase-1-dependent pyroptosis in murine peritoneal B1a B cells. Infect Immun 84(12):3638\u20133654. https:\/\/doi.org\/10.1128\/IAI.00694-16","journal-title":"Infect Immun"},{"issue":"2","key":"10_CR96","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/cmi.12494","volume":"18","author":"J Schulze-Luehrmann","year":"2016","unstructured":"Schulze-Luehrmann J, Eckart RA, Olke M, Saftig P, Liebler-Tenorio E, L\u00fchrmann A (2016) LAMP proteins account for the maturation delay during the establishment of the Coxiella burnetii-containing vacuole. Cell Microbiol 18(2):181\u2013194. https:\/\/doi.org\/10.1111\/cmi.12494","journal-title":"Cell Microbiol"},{"issue":"3","key":"10_CR97","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1083\/jcb.142.3.665","volume":"142","author":"MN Seaman","year":"1998","unstructured":"Seaman MN, McCaffery JM, Emr SD (1998) A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142(3):665\u2013681. https:\/\/doi.org\/10.1083\/jcb.142.3.665","journal-title":"J Cell Biol"},{"issue":"1","key":"10_CR98","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.femsre.2004.07.001","volume":"29","author":"G Segal","year":"2005","unstructured":"Segal G, Feldman M, Zusman T (2005) The Icm\/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii. FEMS Microbiol Rev 29(1):65\u201381. https:\/\/doi.org\/10.1016\/j.femsre.2004.07.001","journal-title":"FEMS Microbiol Rev"},{"issue":"9","key":"10_CR99","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.1073\/pnas.0931379100","volume":"100","author":"R Seshadri","year":"2003","unstructured":"Seshadri R, Paulsen IT, Eisen JA, Read TD, Nelson KE, Nelson WC, Ward NL, Tettelin H, Davidsen TM, Beanan MJ, Deboy RT, Daugherty SC, Brinkac LM, Madupu R, Dodson RJ, Khouri HM, Lee KH, Carty HA, Scanlan D, Heinzen RA, Thompson HA, Samuel JE, Fraser CM, Heidelberg JF (2003) Complete genome sequence of the Q-fever pathogen Coxiella burnetii. Proc Natl Acad Sci USA 100(9):5455\u20135460. https:\/\/doi.org\/10.1073\/pnas.0931379100","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10_CR100","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tim.2014.01.005","volume":"22","author":"H Sridharan","year":"2014","unstructured":"Sridharan H, Upton JW (2014) Programmed necrosis in microbial pathogenesis. Trends Microbiol 22(4):199\u2013207. https:\/\/doi.org\/10.1016\/j.tim.2014.01.005","journal-title":"Trends Microbiol"},{"key":"10_CR101","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fcimb.2017.00025","volume":"7","author":"EJ Schaik van","year":"2017","unstructured":"van Schaik EJ, Case ED, Martinez E, Bonazzi M, Samuel JE (2017) The SCID mouse model for identifying virulence determinants in Coxiella burnetii. Front Cell Infect Microbiol 7:25. https:\/\/doi.org\/10.3389\/fcimb.2017.00025","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"10_CR01","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nrmicro3049","volume":"11","author":"Erin J. van Schaik","year":"2013","unstructured":"van Schaik EJ, Chen C, Mertens K, Weber MM, Samuel JE (2013) Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii. Nat Rev Microbiol 11(8):561\u2013573","journal-title":"Nature Reviews Microbiology"},{"issue":"3","key":"10_CR102","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/cdd.2009.129","volume":"17","author":"CL Vazquez","year":"2010","unstructured":"Vazquez CL, Colombo MI (2010) Coxiella burnetii modulates Beclin 1 and Bcl-2, preventing host cell apoptosis to generate a persistent bacterial infection. Cell Death Differ 17(3):421\u2013438. https:\/\/doi.org\/10.1038\/cdd.2009.129","journal-title":"Cell Death Differ"},{"issue":"4","key":"10_CR103","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1111\/j.1462-5822.2007.00901.x","volume":"9","author":"DE Voth","year":"2007","unstructured":"Voth DE, Heinzen RA (2007) Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Cell Microbiol 9(4):829\u2013840. https:\/\/doi.org\/10.1111\/j.1462-5822.2007.00901.x","journal-title":"Cell Microbiol"},{"issue":"1","key":"10_CR104","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1128\/IAI.01124-08","volume":"77","author":"DE Voth","year":"2009","unstructured":"Voth DE, Heinzen RA (2009) Sustained activation of Akt and Erk1\/2 is required for Coxiella burnetii antiapoptotic activity. Infect Immun 77(1):205\u2013213. https:\/\/doi.org\/10.1128\/IAI.01124-08","journal-title":"Infect Immun"},{"issue":"9","key":"10_CR105","doi-asserted-by":"publisher","first-page":"4263","DOI":"10.1128\/IAI.00594-07","volume":"75","author":"DE Voth","year":"2007","unstructured":"Voth DE, Howe D, Heinzen RA (2007) Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages. Infect Immun 75(9):4263\u20134271. https:\/\/doi.org\/10.1128\/IAI.00594-07","journal-title":"Infect Immun"},{"issue":"7","key":"10_CR106","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1128\/JB.01359-10","volume":"193","author":"DE Voth","year":"2011","unstructured":"Voth DE, Beare PA, Howe D, Sharma UM, Samoilis G, Cockrell DC, Omsland A, Heinzen RA (2011) The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates. J Bacteriol 193(7):1493\u20131503. https:\/\/doi.org\/10.1128\/JB.01359-10","journal-title":"J Bacteriol"},{"issue":"9","key":"10_CR107","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1111\/j.1462-5822.2010.01499.x","volume":"12","author":"K Wallden","year":"2010","unstructured":"Wallden K, Rivera-Calzada A, Waksman G (2010) Type IV secretion systems: versatility and diversity in function. Cell Microbiol 12(9):1203\u20131212. https:\/\/doi.org\/10.1111\/j.1462-5822.2010.01499.x","journal-title":"Cell Microbiol"},{"issue":"17","key":"10_CR108","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1128\/JB.00071-13","volume":"195","author":"MM Weber","year":"2013","unstructured":"Weber MM, Chen C, Rowin K, Mertens K, Galvan G, Zhi H, Dealing CM, Roman VA, Banga S, Tan Y, Luo ZQ, Samuel JE (2013) Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formation. J Bacteriol 195(17):3914\u20133924. https:\/\/doi.org\/10.1128\/JB.00071-13","journal-title":"J Bacteriol"},{"issue":"5","key":"10_CR109","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.micinf.2016.01.003","volume":"18","author":"MM Weber","year":"2016","unstructured":"Weber MM, Faris R, McLachlan J, Tellez A, Wright WU, Galvan G, Luo ZQ, Samuel JE (2016) Modulation of the host transcriptome by Coxiella burnetii nuclear effector Cbu1314. Microbes Infect 18(5):336\u2013345. https:\/\/doi.org\/10.1016\/j.micinf.2016.01.003","journal-title":"Microbes Infect"},{"issue":"6","key":"10_CR110","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1128\/IAI.01236-13","volume":"82","author":"CG Winchell","year":"2014","unstructured":"Winchell CG, Graham JG, Kurten RC, Voth DE (2014) Coxiella burnetii type IV secretion-dependent recruitment of macrophage autophagosomes. Infect Immun 82(6):2229\u20132238. https:\/\/doi.org\/10.1128\/IAI.01236-13","journal-title":"Infect Immun"},{"issue":"11","key":"10_CR02","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.str.2005.09.006","volume":"13","author":"Xinchao Yu","year":"2005","unstructured":"Yu X, Acehan D, Menetret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW (2005) A structure of the human apoptosome at 12.8 \u00c5 resolution provides insights into this cell death platform. Structure 13:1725\u20131735","journal-title":"Structure"},{"issue":"1","key":"10_CR111","doi-asserted-by":"publisher","first-page":"e30841","DOI":"10.1371\/journal.pone.0030841","volume":"7","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Zhang G, Hendrix LR, Tesh VL, Samuel JE (2012) Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells. PLoS ONE 7(1):e30841. https:\/\/doi.org\/10.1371\/journal.pone.0030841","journal-title":"PLoS ONE"},{"issue":"5","key":"10_CR112","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1111\/j.1365-2958.2007.05604.x","volume":"63","author":"T Zusman","year":"2007","unstructured":"Zusman T, Aloni G, Halperin E, Kotzer H, Degtyar E, Feldman M, Segal G (2007) The response regulator PmrA is a major regulator of the icm\/dot type IV secretion system in Legionella pneumophila and Coxiella burnetii. Mol Microbiol 63(5):1508\u20131523. https:\/\/doi.org\/10.1111\/j.1365-2958.2007.05604.x","journal-title":"Mol Microbiol"}],"container-title":["Current Topics in Microbiology and Immunology","Type IV Secretion in Gram-Negative and Gram-Positive Bacteria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-75241-9_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T02:48:23Z","timestamp":1603939703000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-75241-9_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319752402","9783319752419"],"references-count":108,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-75241-9_10","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"14 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}