{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:10:26Z","timestamp":1790838626729,"version":"4.1.0"},"publisher-location":"Cham","reference-count":191,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319752402","type":"print"},{"value":"9783319752419","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-3-319-75241-9_8","type":"book-chapter","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T08:13:07Z","timestamp":1520928787000},"page":"187-220","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling"],"prefix":"10.1007","author":[{"given":"Steffen","family":"Backert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gerhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Naumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"issue":"3","key":"8_CR1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.bbrc.2004.07.199","volume":"322","author":"L Al-Ghoul","year":"2004","unstructured":"Al-Ghoul L, Wessler S, Hundertmark T, Kr\u00fcger S, Fischer W, Wunder C, Roessner A, Naumann M (2004) Analysis of the type IV secretion system-dependent cell motility of H. pylori-infected epithelial cells. Biochem Biophys Res Commun 322(3):860\u2013866. https:\/\/doi.org\/10.1016\/j.bbrc.2004.07.199","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"8_CR2","doi-asserted-by":"publisher","first-page":"8099","DOI":"10.4049\/jimmunol.0900664","volume":"183","author":"CC Allison","year":"2009","unstructured":"Allison CC, Kufer TA, Kremmer E, Kaparakis M, Ferrero RL (2009) H. pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism. J Immunol 183(12):8099\u20138109. https:\/\/doi.org\/10.4049\/jimmunol.0900664","journal-title":"J Immunol"},{"issue":"1","key":"8_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1053\/j.gastro.2015.09.004","volume":"150","author":"M Amieva","year":"2016","unstructured":"Amieva M, Peek RM Jr (2016) Pathobiology of H. pylori-Induced Gastric Cancer. Gastroenterology 150(1):64\u201378. https:\/\/doi.org\/10.1053\/j.gastro.2015.09.004","journal-title":"Gastroenterology"},{"issue":"16","key":"8_CR4","doi-asserted-by":"publisher","first-page":"5865","DOI":"10.1128\/JB.00060-06","volume":"188","author":"J Andrzejewska","year":"2006","unstructured":"Andrzejewska J, Lee SK, Olbermann P, Lotzing N, Katzowitsch E, Linz B, Achtman M, Kado CI, Suerbaum S, Josenhans C (2006) Characterization of the pilin ortholog of the H. pylori type IV cag pathogenicity apparatus, a surface-associated protein expressed during infection. J Bacteriol 188(16):5865\u20135877","journal-title":"J Bacteriol"},{"issue":"9","key":"8_CR5","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1084\/jem.20030381","volume":"198","author":"RA Aras","year":"2003","unstructured":"Aras RA, Fischer W, Perez-Perez GI, Crosatti M, Ando T, Haas R, Blaser MJ (2003) Plasticity of repetitive DNA sequences within a bacterial (Type IV) secretion system component. J Exp Med 198(9):1349\u20131360. https:\/\/doi.org\/10.1084\/jem.20030381","journal-title":"J Exp Med"},{"issue":"4","key":"8_CR6","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1084\/jem.191.4.593","volume":"191","author":"M Asahi","year":"2000","unstructured":"Asahi M, Azuma T, Ito S, Ito Y, Suto H, Nagai Y, Tsubokawa M, Tohyama Y, Maeda S, Omata M, Suzuki T, Sasakawa C (2000) H. pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med 191(4):593\u2013602","journal-title":"J Exp Med"},{"issue":"10","key":"8_CR7","first-page":"4139","volume":"33","author":"S Ayyappan","year":"2013","unstructured":"Ayyappan S, Prabhakar D, Sharma N (2013) Epidermal growth factor receptor (EGFR)-targeted therapies in esophagogastric cancer. Anticancer Res 33(10):4139\u20134155","journal-title":"Anticancer Res"},{"key":"8_CR006","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1523-5378.2011.00876.x","volume":"16","author":"Steffen Backert","year":"2011","unstructured":"Backert S, Clyne M (2011) Pathogenesis of Helicobacter pylori Infection. Helicobacter 16:19\u201325","journal-title":"Helicobacter"},{"issue":"1","key":"8_CR8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1478-811X-9-28","volume":"9","author":"Steffen Backert","year":"2011","unstructured":"Backert S, Clyne M, Tegtmeyer N (2011) Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori. Cell Commun Signal 9:28. https:\/\/doi.org\/10.1186\/1478-811X-9-28","journal-title":"Cell Communication and Signaling"},{"issue":"9","key":"8_CR01","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.tim.2008.07.001","volume":"16","author":"Steffen Backert","year":"2008","unstructured":"Backert S, Fronzes R, Waksman G (2008) VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems? Trends Microbiol 16(9): 409\u2013413. https:\/\/doi.org\/10.1016\/j.tim.2008.07.001","journal-title":"Trends in Microbiology"},{"issue":"11","key":"8_CR9","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1099\/mic.0.28250-0","volume":"151","author":"S. Backert","year":"2005","unstructured":"Backert S, Kwok T, K\u00f6nig W (2005) Conjugative plasmid DNA transfer in Helicobacter pylori mediated by chromosomally encoded relaxase and TraG-like proteins. Microbiology 151(Pt 11):3493\u20133503","journal-title":"Microbiology"},{"issue":"3","key":"8_CR008","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1046\/j.1365-2958.2001.02649.x","volume":"42","author":"Steffen Backert","year":"2008","unstructured":"Backert S, Moese S, Selbach M, Brinkmann V, Meyer TF (2001) Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Mol Microbiol 42(3):631\u2013644","journal-title":"Molecular Microbiology"},{"issue":"4","key":"8_CR002","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/toxins9040115","volume":"9","author":"Steffen Backert","year":"2017","unstructured":"Backert S, Tegtmeyer N (2017) Type IV secretion and signal transduction of Helicobacter pylori CagA through interactions with host cell receptors. Toxins 9(4):115","journal-title":"Toxins"},{"issue":"3","key":"8_CR10","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1046\/j.1365-2958.1998.01086.x","volume":"30","author":"Steffen Backert","year":"1998","unstructured":"Backert S, Von Nickisch-Rosenegk E, Meyer TF (1998) Potential role of two Helicobacter pylori relaxases in DNA transfer? Mol Microbiol 30(3):673\u2013674","journal-title":"Molecular Microbiology"},{"issue":"2","key":"8_CR11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.mib.2006.02.008","volume":"9","author":"Steffen Backert","year":"2006","unstructured":"Backert S, Meyer TF (2006) Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin Microbiol 9(2):207\u2013217. https:\/\/doi.org\/10.1016\/j.mib.2006.02.008","journal-title":"Current Opinion in Microbiology"},{"key":"8_CR12","doi-asserted-by":"publisher","unstructured":"Backert S, Schmidt TP, Harrer A, Wessler S (2017) Exploiting the gastric epithelial barrier: Helicobacter pylori\u2019s attack on tight and adherens junctions. Curr Top Microbiol Immunol 400:195\u2013226. https:\/\/doi.org\/10.1007\/978-3-319-50520-6_9","DOI":"10.1007\/978-3-319-50520-6_9"},{"issue":"6","key":"8_CR13","doi-asserted-by":"publisher","first-page":"955","DOI":"10.2217\/fmb.15.32","volume":"10","author":"Steffen Backert","year":"2015","unstructured":"Backert S, Tegtmeyer N, Fischer W (2015) Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system. Future Microbiol 10(6):955\u2013965. https:\/\/doi.org\/10.2217\/fmb.15.32","journal-title":"Future Microbiology"},{"issue":"3","key":"8_CR14","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1523-5378.2010.00759.x","volume":"15","author":"Steffen Backert","year":"2010","unstructured":"Backert S, Tegtmeyer N, Selbach M (2010) The versatility of Helicobacter pylori CagA effector protein functions: the master key hypothesis. Helicobacter 15(3):163\u2013176. https:\/\/doi.org\/10.1111\/j.1523-5378.2010.00759.x","journal-title":"Helicobacter"},{"issue":"2","key":"8_CR15","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1046\/j.1462-5822.2000.00043.x","volume":"2","author":"Steffen Backert","year":"2000","unstructured":"Backert S, Ziska E, Brinkmann V, Zimny-Arndt U, Fauconnier A, Jungblut PR, Naumann M, Meyer TF (2000) Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus. Cell Microbiol 2(2):155\u2013164","journal-title":"Cellular Microbiology"},{"issue":"5","key":"8_CR16","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/hel.12300","volume":"21","author":"Aditi Banerjee","year":"2016","unstructured":"Banerjee A, Basu M, Blanchard TG, Chintalacharuvu SR, Guang W, Lillehoj EP, Czinn SJ (2016) Early molecular events in murine gastric epithelial cells mediated by H.pylori CagA. Helicobacter 21(5):395\u2013404. https:\/\/doi.org\/10.1111\/hel.12300","journal-title":"Helicobacter"},{"issue":"11","key":"8_CR17","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/j.str.2013.08.018","volume":"21","author":"Stephan Barden","year":"2013","unstructured":"Barden S, Lange S, Tegtmeyer N, Conradi J, Sewald N, Backert S, Niemann HH (2013) A helical RGD motif promoting cell adhesion: crystal structures of the Helicobacter pylori type IV secretion system pilus protein CagL. Structure\u00a021(11):1931\u20131941. https:\/\/doi.org\/10.1016\/j.str.2013.08.018","journal-title":"Structure"},{"key":"8_CR18","doi-asserted-by":"publisher","unstructured":"Barden S, Niemann HH (2015) Adhesion of several cell lines to H. pylori CagL is mediated by integrin alphaVbeta6 via an RGDLXXL motif. J Mol Biol 427:1304\u20131315. https:\/\/doi.org\/10.1016\/j.jmb.2015.01.006","DOI":"10.1016\/j.jmb.2015.01.006"},{"issue":"2","key":"8_CR19","doi-asserted-by":"publisher","first-page":"e1003189","DOI":"10.1371\/journal.ppat.1003189","volume":"9","author":"Roberto M. Barrozo","year":"2013","unstructured":"Barrozo RM, Cooke CL, Hansen LM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM Jr, Cover TL, Solnick JV (2013) Functional plasticity in the type IV secretion system of H. pylori. PLoS Pathog 9:e1003189. https:\/\/doi.org\/10.1371\/journal.ppat.1003189","journal-title":"PLoS Pathogens"},{"issue":"6","key":"8_CR20","doi-asserted-by":"publisher","first-page":"1164-1175.e3","DOI":"10.1053\/j.gastro.2016.08.014","volume":"151","author":"Roberto M. Barrozo","year":"2016","unstructured":"Barrozo RM, Hansen LM, Lam AM, Skoog EC, Martin ME, Cai LP, Lin Y, Latoscha A, Suerbaum S, Canfield DR, Solnick JV (2016) CagY is an immune-sensitive regulator of the H. pylori type IV secretion system. Gastroenterology 151(6):1164\u20131175. https:\/\/doi.org\/10.1053\/j.gastro.2016.08.014","journal-title":"Gastroenterology"},{"key":"8_CR21","unstructured":"Basak C, Pathak SK, Bhattacharyya A, Pathak S, Basu J, Kundu M (2005) The secreted peptidyl prolyl cis, trans-isomerase HP0175 of H. pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent manner. J Immunol 174(9):5672\u20135680"},{"issue":"1","key":"8_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1462-5822.2008.01246.x","volume":"11","author":"Bianca Bauer","year":"2009","unstructured":"Bauer B, Bartfeld S, Meyer TF (2009) H. pylori selectively blocks EGFR endocytosis via the non-receptor kinase c-Abl and CagA. Cell Microbiol 11(1):156\u2013169. https:\/\/doi.org\/10.1111\/j.1462-5822.2008.01246.x","journal-title":"Cellular Microbiology"},{"key":"8_CR23","unstructured":"Bauer B, Pang E, Holland C, Kessler M, Bartfeld S, Meyer TF (2012) The H.pylori virulence effector CagA abrogates human \u03b2-defensin 3 expression via inactivation of EGFR signaling. Cell Host Microbe 11(6):576\u2013586"},{"issue":"12","key":"8_CR004","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1136\/jcp.2006.036772","volume":"59","author":"J R Bebb","year":"2006","unstructured":"Bebb JR, Leach L, Zaitoun A, Hand N, Letley DP, Thomas R, Atherton JC (2006) Effects of Helicobacter pylori on the cadherin-catenin complex. J Clin Pathol 59(12):1261\u20131266","journal-title":"Journal of Clinical Pathology"},{"key":"8_CR24","doi-asserted-by":"publisher","unstructured":"Belogolova E, Bauer B, Pompaiah M, Asakura H, Brinkman V, Ertl C, Bartfeld S, Nechitaylo TY, Haas R, Machuy N, Salama N, Churin Y, Meyer TF (2013) H. pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor. Cell Microbiol 15(11):1896\u20131912. https:\/\/doi.org\/10.1111\/cmi.12158","DOI":"10.1111\/cmi.12158"},{"key":"8_CR25","doi-asserted-by":"publisher","unstructured":"Berg\u00e9 C, Terradot L (2017) Structural insights into H. pylori cag protein interactions with host cell factors. Curr Top Microbiol Immunol 400:129\u2013147. https:\/\/doi.org\/10.1007\/978-3-319-50520-6_6","DOI":"10.1007\/978-3-319-50520-6_6"},{"key":"8_CR26","doi-asserted-by":"publisher","unstructured":"B\u00f6nig T, Olbermann P, Bats SH, Fischer W, Josenhans C (2016) Systematic site-directed mutagenesis of the H. pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. Sci Rep 6:38101. https:\/\/doi.org\/10.1038\/srep38101","DOI":"10.1038\/srep38101"},{"key":"8_CR27","doi-asserted-by":"publisher","unstructured":"Bonsor DA, Weiss E, Iosub-Amir A, Reingewertz TH, Haas R, Friedler A, Fischer W, Sundberg EJ (2013) Characterization of the translocation-competent complex between the H. pylori oncogenic protein CagA and the accessory protein CagF. J Biol Chem 288(46):32897\u201332909. https:\/\/doi.org\/10.1074\/jbc.M113.507657","DOI":"10.1074\/jbc.M113.507657"},{"key":"8_CR28","doi-asserted-by":"publisher","unstructured":"Bonsor DA, Pham KT, Beadenkopf R, Diederichs K, Haas R, Fischer W, Sundberg EJ (2015) Integrin engagement by the helical RGD motif of the H. pylori CagL protein is regulated by pH-induced displacement of a neighboring helix. J Biol Chem 290(20):12929\u201312940. https:\/\/doi.org\/10.1074\/jbc.M115.641829","DOI":"10.1074\/jbc.M115.641829"},{"key":"8_CR29","doi-asserted-by":"publisher","unstructured":"Boquet P, Ricci V (2012) Intoxication strategy of H. pylori VacA toxin. Trends Microbiol 20(4):165\u2013174. https:\/\/doi.org\/10.1016\/j.tim.2012.01.008","DOI":"10.1016\/j.tim.2012.01.008"},{"key":"8_CR30","doi-asserted-by":"publisher","unstructured":"Bradley CA, Salto-Tellez M, Laurent-Puig P, Bardelli A, Rolfo C, Tabernero J, Khawaja HA, Lawler M, Johnston PG, Van Schaeybroeck S, Consortium ME (2017) Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges. Nat Rev Clin Oncol https:\/\/doi.org\/10.1038\/nrclinonc.2017.40","DOI":"10.1038\/nrclinonc.2017.40"},{"issue":"1","key":"8_CR009","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.femsle.2005.06.008","volume":"249","author":"Mikael Brisslert","year":"2005","unstructured":"Brisslert M, Enarsson K, Lundin S, Karlsson A, Kusters JG, Svennerholm AM, Backert S, Quiding-J\u00e4rbrink M (2005) Helicobacter pylori induce neutrophil transendothelial migration: role of the bacterial HP-NAP. FEMS Microbiol Lett 249(1):95\u2013103","journal-title":"FEMS Microbiology Letters"},{"key":"8_CR31","unstructured":"Cao X, Tsukamoto T, Nozaki K, Mizoshita T, Ogasawara N, Takenaka Y, Kaminishi M, Tatematsu M (2004) Beta-catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and H. pylori-infected Mongolian gerbils. Cancer Sci 95(6):487\u2013490"},{"issue":"1","key":"8_CR32","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1146\/annurev-biochem-062911-102821","volume":"84","author":"Vidya Chandran Darbari","year":"2015","unstructured":"Chandran Darbari V, Waksman G (2015) Structural biology of bacterial type IV secretion systems. Annu Rev Biochem 84:603\u2013629. https:\/\/doi.org\/10.1146\/annurev-biochem-062911-102821","journal-title":"Annual Review of Biochemistry"},{"issue":"7","key":"8_CR33","doi-asserted-by":"publisher","first-page":"1739-1751.e14","DOI":"10.1053\/j.gastro.2014.02.005","volume":"146","author":"Rupesh Chaturvedi","year":"2014","unstructured":"Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Jr, Bravo LE, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Jr, Wilson KT (2014) Activation of EGFR and ERBB2 by H. pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology 146(7):1739\u20131751, e1714. https:\/\/doi.org\/10.1053\/j.gastro.2014.02.005","journal-title":"Gastroenterology"},{"issue":"8","key":"8_CR34","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.bbamcr.2013.12.019","volume":"1843","author":"Peter J. Christie","year":"2014","unstructured":"Christie PJ, Whitaker N, Gonz\u00e1lez-Rivera C (2014) Mechanism and structure of the bacterial type IV secretion systems. Biochim Biophys Acta 1843(8):1578\u20131591. https:\/\/doi.org\/10.1016\/j.bbamcr.2013.12.019","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"issue":"2","key":"8_CR35","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1083\/jcb.200208039","volume":"161","author":"Yuri Churin","year":"2003","unstructured":"Churin Y, Al-Ghoul L, Kepp O, Meyer TF, Birchmeier W, Naumann M (2003) H. pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 161(2):249\u2013255. https:\/\/doi.org\/10.1083\/jcb.200208039","journal-title":"The Journal of Cell Biology"},{"key":"8_CR36","doi-asserted-by":"publisher","unstructured":"Conradi J, Huber S, Gaus K, Mertink F, Royo GS, Strijowski U, Backert S, Sewald N (2012) Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins alphaVbeta3 and alpha5beta1. Amino Acids 43(1):219\u2013232. https:\/\/doi.org\/10.1007\/s00726-011-1066-0","DOI":"10.1007\/s00726-011-1066-0"},{"key":"8_CR37","doi-asserted-by":"publisher","unstructured":"Costa AM, Ferreira RM, Pinto-Ribeiro I, Sougleri IS, Oliveira MJ, Carreto L, Santos MA, Sgouras DN, Carneiro F, Leite M, Figueiredo C (2016) H. pylori activates matrix metalloproteinase 10 in gastric epithelial cells via EGFR and ERK-mediated pathways. J Infect Dis 213(11):1767\u20131776. https:\/\/doi.org\/10.1093\/infdis\/jiw031","DOI":"10.1093\/infdis\/jiw031"},{"key":"8_CR38","unstructured":"Couturier MR, Tasca E, Montecucco C, Stein M (2006) Interaction with CagF is required for translocation of CagA into the host via the H. pylori type IV secretion system. Infect Immun 74(1):273\u2013281"},{"issue":"4","key":"8_CR39","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1084\/jem.191.4.587","volume":"191","author":"Antonello Covacci","year":"2000","unstructured":"Covacci A, Rappuoli R (2000) Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell. J Exp Med 191(4):587\u2013592","journal-title":"The Journal of Experimental Medicine"},{"issue":"5418","key":"8_CR40","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1126\/science.284.5418.1328","volume":"284","author":"A. Covacci","year":"1999","unstructured":"Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R (1999) H. pylori virulence and genetic geography. Science 284(5418):1328\u20131333","journal-title":"Science"},{"key":"8_CR41","doi-asserted-by":"publisher","unstructured":"Coyle WJ, Sedlack RE, Nemec R, Peterson R, Duntemann T, Murphy M, Lawson JM (1999) Eradication of H. pylori normalizes elevated mucosal levels of epidermal growth factor and its receptor. Am J Gastroenterol 94(10):2885\u20132889. https:\/\/doi.org\/10.1111\/j.1572-0241.1999.01432.x","DOI":"10.1111\/j.1572-0241.1999.01432.x"},{"issue":"3","key":"8_CR42","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1042\/BJ20100323","volume":"429","author":"Cuadrado and Nebreda","year":"2010","unstructured":"Cuadrado and Nebreda (2010) Mechanisms and functions of p38 MAPK signaling. Biochem J 429(3):403\u2013411. https:\/\/doi.org\/10.1042\/BJ20100323","journal-title":"Biochem J"},{"issue":"3","key":"8_CR43","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.jmb.2008.01.053","volume":"377","author":"RM Delahay","year":"2008","unstructured":"Delahay RM, Balkwill GD, Bunting KA, Edwards W, Atherton JC, Searle MS (2008) The highly repetitive region of the H. pylori CagY protein comprises tandem arrays of an alpha-helical repeat module. J Mol Biol 377(3):956\u2013971. https:\/\/doi.org\/10.1016\/j.jmb.2008.01.053","journal-title":"J Mol Biol"},{"issue":"3","key":"8_CR44","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1574-695X.2008.00439.x","volume":"53","author":"SZ Ding","year":"2008","unstructured":"Ding SZ, Olekhnovich IN, Cover TL, Peek RM Jr, Smith MF Jr, Goldberg JB (2008) H. pylori and mitogen-activated protein kinases mediate activator protein-1 subcomponent protein expression and DNA-binding activity in gastric epithelial cells. FEMS Immunol Med Microbiol 53(3):385\u2013394. https:\/\/doi.org\/10.1111\/j.1574-695X.2008.00439.x","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"5","key":"8_CR45","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1111\/j.1462-5822.2007.00921.x","volume":"9","author":"A Dubois","year":"2007","unstructured":"Dubois A, Bor\u00e9n T (2007) H. pylori is invasive and it may be a facultative intracellular organism. Cell Microbiol 9(5):1108\u20131116. https:\/\/doi.org\/10.1111\/j.1462-5822.2007.00921.x","journal-title":"Cell Microbiol"},{"issue":"4","key":"8_CR46","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1007\/s00535-014-0938-y","volume":"49","author":"E Fernandez-Gonzalez","year":"2014","unstructured":"Fernandez-Gonzalez E, Backert S (2014) DNA transfer in the gastric pathogen Helicobacter pylori. J Gastroenterol 49(4):594\u2013604. https:\/\/doi.org\/10.1007\/s00535-014-0938-y","journal-title":"J Gastroenterol"},{"issue":"8","key":"8_CR47","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1111\/j.1742-4658.2011.08036.x","volume":"278","author":"W Fischer","year":"2011","unstructured":"Fischer W (2011) Assembly and molecular mode of action of the H. pylori cag type IV secretion apparatus. FEBS J 278(8):1203\u20131212. https:\/\/doi.org\/10.1111\/j.1742-4658.2011.08036.x","journal-title":"FEBS J"},{"issue":"5","key":"8_CR48","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1046\/j.1365-2958.2001.02714.x","volume":"42","author":"W Fischer","year":"2001","unstructured":"Fischer W, P\u00fcls J, Buhrdorf R, Gebert B, Odenbreit S, Haas R (2001) Systematic mutagenesis of the H. pylori cag island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol Microbiol 42(5):1337\u20131348","journal-title":"Mol Microbiol"},{"key":"8_CR49","doi-asserted-by":"publisher","unstructured":"Foegeding NJ, Caston RR, McClain MS, Ohi MD, Cover TL (2016) An overview of H. pylori VacA toxin biology. Toxins (Basel) 8(6) pii: E173. https:\/\/doi.org\/10.3390\/toxins8060173","DOI":"10.3390\/toxins8060173"},{"key":"8_CR50","doi-asserted-by":"publisher","unstructured":"Franco AT1, Johnston E, Krishna U, Israel DA, Nagy TA, Wroblewski LE, Piazuelo MB, Correa P, Peek RM Jr (2008) Regulation of gastric carcinogenesis by H. pylori virulence factors. Cancer Res 68(2):379\u2013387. https:\/\/doi.org\/10.1158\/0008-5472.can-07-0824","DOI":"10.1158\/0008-5472.can-07-0824"},{"issue":"1","key":"8_CR51","doi-asserted-by":"publisher","first-page":"e02001","DOI":"10.1128\/mBio.02001-15","volume":"7","author":"Arwen E. Frick-Cheng","year":"2016","unstructured":"Frick-Cheng AE, Pyburn TM, Voss BJ, McDonald WH, Ohi MD, Cover TL (2016) Molecular and structural analysis of the H. pylori cag type IV secretion system core complex. MBio 7(1):e02001\u201315. https:\/\/doi.org\/10.1128\/mbio.02001-15","journal-title":"mBio"},{"issue":"10","key":"8_CR52","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nrmicro2218","volume":"7","author":"R Fronzes","year":"2009","unstructured":"Fronzes R, Christie PJ, Waksman G (2009a) The structural biology of type IV secretion systems. Nat Rev Microbiol 7(10):703\u2013714. https:\/\/doi.org\/10.1038\/nrmicro2218","journal-title":"Nat Rev Microbiol"},{"issue":"5911","key":"8_CR53","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1126\/science.1166101","volume":"323","author":"R Fronzes","year":"2009","unstructured":"Fronzes R, Sch\u00e4fer E, Wang L, Saibil HR, Orlova E, Waksman G (2009b) Structure of a type IV secretion system core complex. Science 323(5911):266\u2013268. https:\/\/doi.org\/10.1126\/science.1166101","journal-title":"Science"},{"issue":"10","key":"8_CR54","doi-asserted-by":"publisher","first-page":"e1004450","DOI":"10.1371\/journal.ppat.1004450","volume":"10","author":"JA Gaddy","year":"2014","unstructured":"Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM (2014) The host protein calprotectin modulates the H. pylori cag type IV secretion system via zinc sequestration. PLoS Pathog 10(10):e1004450. https:\/\/doi.org\/10.1371\/journal.ppat.1004450","journal-title":"PLoS Pathog"},{"key":"8_CR55","doi-asserted-by":"publisher","unstructured":"Gall A, Gaudet RG, Gray-Owen SD, Salama NR (2017) TIFA Signaling in gastric epithelial cells initiates the cag type 4 secretion system-dependent innate immune response to Helicobacter pylori infection. MBio 8(4) pii: e01168\u201317. https:\/\/doi.org\/10.1128\/mbio.01168-17","DOI":"10.1128\/mbio.01168-17"},{"key":"8_CR56","doi-asserted-by":"publisher","unstructured":"Glowinski F, Holland C, Thiede B, Jungblut PR, Meyer TF (2014) Analysis of T4SS-induced signaling by H. pylori using quantitative phosphoproteomics. Front Microbiol 5:356. https:\/\/doi.org\/10.3389\/fmicb.2014.00356","DOI":"10.3389\/fmicb.2014.00356"},{"issue":"1","key":"8_CR57","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.bbrc.2014.11.041","volume":"456","author":"GJ Gopal","year":"2015","unstructured":"Gopal GJ, Pal J, Kumar A, Mukhopadhyay G (2015) C-terminal domain of CagX is responsible for its interaction with CagT protein of H. pylori type IV secretion system. Biochem Biophys Res Commun 456(1):98\u2013103. https:\/\/doi.org\/10.1016\/j.bbrc.2014.11.041","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"8_CR58","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/mmi.13896","volume":"107","author":"Elisabeth Grohmann","year":"2018","unstructured":"Grohmann E, Christie PJ, Waksman G, Backert S (2018) Type IV secretion in gram-negative and gram-positive bacteria. Mol Microbiol 107:455\u2013471. https:\/\/doi.org\/10.1111\/mmi.13896","journal-title":"Molecular Microbiology"},{"issue":"37","key":"8_CR59","doi-asserted-by":"publisher","first-page":"26385","DOI":"10.1074\/jbc.M113.496430","volume":"288","author":"JI Grove","year":"2013","unstructured":"Grove JI, Alandiyjany MN, Delahay RM (2013) Site-specific relaxase activity of a VirD2-like protein encoded within the tfs4 genomic island of Helicobacter pylori. J Biol Chem 288(37):26385\u201326396. https:\/\/doi.org\/10.1074\/jbc.M113.496430","journal-title":"J Biol Chem"},{"key":"8_CR60","doi-asserted-by":"publisher","unstructured":"Haley KP, Blanz EJ, Gaddy JA (2014) High resolution electron microscopy of the H. pylori cag type IV secretion system pili produced in varying conditions of iron availability. J Vis Exp (93):e52122. https:\/\/doi.org\/10.3791\/52122","DOI":"10.3791\/52122"},{"issue":"3","key":"8_CR02","doi-asserted-by":"publisher","first-page":"G193","DOI":"10.1152\/ajpgi.00099.2015","volume":"309","author":"Charles E. Hammond","year":"2015","unstructured":"Hammond CE, Beeson C, Suarez G, Peek RMJr, Backert S, Smolka AJ (2015) Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. Am J Physiol Gastrointest Liver Physiol. 309(3):G193\u2013201. https:\/\/doi.org\/10.1152\/ajpgi.00099.2015","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"8_CR61","doi-asserted-by":"publisher","unstructured":"Harrer A, Boehm M, Backert S, Tegtmeyer N (2017) Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori. Gut Pathog 9:40. https:\/\/doi.org\/10.1186\/s13099-017-0189-6","DOI":"10.1186\/s13099-017-0189-6"},{"key":"8_CR62","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.1038\/sj.emboj.7601904","volume":"26","author":"S Hare","year":"2007","unstructured":"Hare S, Fischer W, Williams R, Terradot L, Bayliss R, Haas R, Waksman G (2007) Identification, structure and mode of action of a new regulator of the H. pylori HP0525 ATPase. EMBO J 26:4926\u20134934. https:\/\/doi.org\/10.1038\/sj.emboj.7601904","journal-title":"EMBO J"},{"key":"8_CR63","doi-asserted-by":"publisher","unstructured":"Hartung ML, Gruber DC, Koch KN, Gr\u00fcter L, Rehrauer H, Tegtmeyer N, Backert S, M\u00fcller A. (2015) H. pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote NF-\u03baB target gene expression. Cell Rep 13(1):70\u201379. https:\/\/doi.org\/10.1016\/j.celrep.2015.08.074","DOI":"10.1016\/j.celrep.2015.08.074"},{"issue":"12","key":"8_CR64","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.1128\/IAI.00914-13","volume":"81","author":"Y Hayakawa","year":"2013","unstructured":"Hayakawa Y, Hirata Y, Kinoshita H, Sakitani K, Nakagawa H, Nakata W, Takahashi R, Sakamoto K, Maeda S, Koike K (2013) Differential roles of ASK1 and TAK1 in H. pylori-induced cellular responses. Infect Immun 81(12):4551\u20134560. https:\/\/doi.org\/10.1128\/IAI.00914-13","journal-title":"Infect Immun"},{"issue":"1","key":"8_CR65","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.chom.2012.05.010","volume":"12","author":"T Hayashi","year":"2012","unstructured":"Hayashi T, Senda M, Morohashi H, Higashi H, Horio M, Kashiba Y, Nagase L, Sasaya D, Shimizu T, Venugopalan N, Kumeta H, Noda NN, Inagaki F, Senda T, Hatakeyama M (2012) Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of H. pylori oncogenic effector CagA. Cell Host Microbe 12(1):20\u201333. https:\/\/doi.org\/10.1016\/j.chom.2012.05.010","journal-title":"Cell Host Microbe"},{"issue":"5","key":"8_CR66","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1200\/JCO.2015.62.6598","volume":"34","author":"JR Hecht","year":"2016","unstructured":"Hecht JR, Bang YJ, Qin SK, Chung HC, Xu JM, Park JO, Jeziorski K, Shparyk Y, Hoff PM, Sobrero A, Salman P, Li J, Protsenko SA, Wainberg ZA, Buyse M, Afenjar K, Houe V, Garcia A, Kaneko T, Huang Y, Khan-Wasti S, Santillana S, Press MF, Slamon D (2016) Lapatinib in combination with capecitabine plus oxaliplatin in human EGFR2-positive advanced or metastatic gastric, esophageal, or gastroesophageal adenocarcinoma: TRIO-013\/LOGiC\u2013A randomized phase III trial. J Clin Oncol 34(5):443\u2013451. https:\/\/doi.org\/10.1200\/JCO.2015.62.6598","journal-title":"J Clin Oncol"},{"key":"8_CR67","doi-asserted-by":"publisher","unstructured":"Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, Hatakeyama M (2002) SHP-2 tyrosine phosphatase as an intracellular target of H. pylori CagA protein. Science 295(5555):683\u2013686. https:\/\/doi.org\/10.1126\/science.1067147","DOI":"10.1126\/science.1067147"},{"issue":"6","key":"8_CR68","doi-asserted-by":"publisher","first-page":"3796","DOI":"10.4049\/jimmunol.176.6.3796","volume":"176","author":"Y Hirata","year":"2006","unstructured":"Hirata Y, Ohmae T, Shibata W, Maeda S, Ogura K, Yoshida H, Kawabe T, Omata M (2006) MyD88 and TNF receptor-associated factor 6 are critical signal transducers in H. pylori-infected human epithelial cells. J Immunol 176(6):3796\u20133803","journal-title":"J Immunol"},{"issue":"3","key":"8_CR69","doi-asserted-by":"publisher","first-page":"967-977.e3","DOI":"10.1053\/j.gastro.2008.12.003","volume":"136","author":"Meegan Howlett","year":"2009","unstructured":"Howlett M, Giraud AS, Lescesen H, Jackson CB, Kalantzis A, Van Driel IR, Robb L, Van der Hoek M, Ernst M, Minamoto T, Boussioutas A, Oshima H, Oshima M, Judd LM (2009) The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. Gastroenterology 136:967\u2013977. https:\/\/doi.org\/10.1053\/j.gastro.2008.12.003","journal-title":"Gastroenterology"},{"issue":"8","key":"8_CR70","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1093\/carcin\/bgs165","volume":"33","author":"KW Hsu","year":"2012","unstructured":"Hsu KW, Hsieh RH, Huang KH, Fen-Yau Li A, Chi CW, Wang TY, Tseng MJ, Wu KJ, Yeh TS (2012) Activation of the notch1\/STAT3\/twist signaling axis promotes gastric cancer progression. Carcinogenesis 33(8):1459\u20131467. https:\/\/doi.org\/10.1093\/carcin\/bgs165","journal-title":"Carcinogenesis"},{"issue":"2","key":"8_CR71","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.chom.2015.07.002","volume":"18","author":"JY Huang","year":"2015","unstructured":"Huang JY, Sweeney EG, Sigal M, Zhang HC, Remington SJ, Cantrell MA, Kuo CJ, Guillemin K, Amieva MR (2015) Chemodetection and destruction of host urea allows H. pylori to locate the epithelium. Cell Host Microbe 18(2):147\u2013156. https:\/\/doi.org\/10.1016\/j.chom.2015.07.002","journal-title":"Cell Host Microbe"},{"key":"8_CR72","doi-asserted-by":"publisher","first-page":"16189","DOI":"10.1038\/nmicrobiol.2016.189","volume":"2","author":"A Javaheri","year":"2016","unstructured":"Javaheri A, Kruse T, Moonens K, Mejias-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Koniger V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M (2016) Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol 2:16189. https:\/\/doi.org\/10.1038\/nmicrobiol.2016.189","journal-title":"Nat Microbiol"},{"issue":"12","key":"8_CR74","doi-asserted-by":"publisher","first-page":"e1000684","DOI":"10.1371\/journal.ppat.1000684","volume":"5","author":"LF Jim\u00e9nez-Soto","year":"2009","unstructured":"Jim\u00e9nez-Soto LF, Kutter S, Sewald X, Ertl C, Rohde M, Pirch T, Jung K, Retta SF, Terradot L, Fischer W, Haas R (2009) H.pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. PLoS Pathog 5(12):e1000684. https:\/\/doi.org\/10.1371\/journal.ppat.1000684","journal-title":"PLoS Pathog"},{"issue":"11","key":"8_CR75","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1111\/cmi.12166","volume":"15","author":"LF Jim\u00e9nez-Soto","year":"2013","unstructured":"Jim\u00e9nez-Soto LF, Clausen S, Sprenger A, Ertl C, Haas R (2013) Dynamics of the Cag-type IV secretion system of H. pylori as studied by bacterial co-infections. Cell Microbiol 15(11):1924\u20131937. https:\/\/doi.org\/10.1111\/cmi.12166","journal-title":"Cell Microbiol"},{"issue":"8","key":"8_CR76","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.1128\/IAI.01640-14","volume":"82","author":"EM Johnson","year":"2014","unstructured":"Johnson EM, Gaddy JA, Voss BJ, Hennig EE, Cover TL (2014) Genes required for assembly of pili associated with the H. pylori cag type IV secretion system. Infect Immun 82(8):3457\u20133470. https:\/\/doi.org\/10.1128\/IAI.01640-14","journal-title":"Infect Immun"},{"key":"8_CR77","doi-asserted-by":"publisher","unstructured":"Kaplan-T\u00fcrk\u00f6z B, Jim\u00e9nez-Soto LF, Ertl C, Remaut H, Louche A, Tosi T, Haas R, Terradot L (2012) Structural insights into H. pylori oncoprotein CagA interaction with \u03b21 integrin. Proc Natl Acad Sci 109(36):14640\u201314645. https:\/\/doi.org\/10.1073\/pnas.1206098109","DOI":"10.1073\/pnas.1206098109"},{"issue":"2","key":"8_CR78","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","volume":"9","author":"K Karin","year":"1997","unstructured":"Karin K, Zq Liu, Zandi E (1997) AP-1 function and regulation. Curr Opin Cell Biol 9(2):240\u2013246","journal-title":"Curr Opin Cell Biol"},{"issue":"3","key":"8_CR79","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s10120-015-0585-x","volume":"19","author":"H Kawakami","year":"2016","unstructured":"Kawakami H, Okamoto I (2016) MET-targeted therapy for gastric cancer: the importance of a biomarker-based strategy. Gastric Cancer 19(3):687\u2013695. https:\/\/doi.org\/10.1007\/s10120-015-0585-x","journal-title":"Gastric Cancer"},{"issue":"10","key":"8_CR80","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.4049\/jimmunol.163.10.5552","volume":"163","author":"S Keates","year":"1999","unstructured":"Keates S, Keates AC, Warny M, Peek RM Jr, Murray PG, Kelly CP (1999) Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+\u00a0and cag- H. pylori. J Immunol 163(10):5552\u20135559","journal-title":"J Immunol"},{"key":"8_CR81","doi-asserted-by":"publisher","first-page":"48127","DOI":"10.1074\/jbc.M107630200","volume":"276","author":"S Keates","year":"2001","unstructured":"Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM Jr, Shaw LM, Kelly CP (2001) cag+\u00a0H. pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem 276:48127\u201348134. https:\/\/doi.org\/10.1074\/jbc.M107630200","journal-title":"J Biol Chem"},{"issue":"3","key":"8_CR82","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.bbrc.2005.06.002","volume":"333","author":"MH Kim","year":"2005","unstructured":"Kim MH, Yoo HS, Chang HJ, Hong MH, Kim HD, Chung IJ, Shin BA, Cho MJ, Ahn BW, Jung YD (2005) Urokinase plasminogen activator receptor is upregulated by H. pylori in human gastric cancer AGS cells via ERK, JNK, and AP-1. Biochem Biophys Res Commun 333(3):874\u2013880. https:\/\/doi.org\/10.1016\/j.bbrc.2005.06.002","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"8_CR83","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1172\/JCI79337","volume":"125","author":"KN Koch","year":"2015","unstructured":"Koch KN, Hartung ML, Urban S, Kyburz A, Bahlmann AS, Lind J, Backert S, Taube C, M\u00fcller A (2015) Helicobacter urease-induced activation of the TLR2\/NLRP3\/IL-18 axis protects against asthma. J Clin Invest 125(8):3297\u20133302. https:\/\/doi.org\/10.1172\/JCI79337","journal-title":"J Clin Invest"},{"key":"8_CR84","doi-asserted-by":"publisher","unstructured":"Kong Y, Ma LQ, Bai PS, Da R, Sun H, Ma JQ, Zhao RM, Chen NZ, Nan KJ (2013) H. pylori promotes invasion and metastasis of gastric cancer cells through activation of AP-1 and up-regulation of CACUL1. Int J Biochem Cell Biol 45(11):2666\u20132678. https:\/\/doi.org\/10.1016\/j.biocel.2013.08.015","DOI":"10.1016\/j.biocel.2013.08.015"},{"key":"8_CR85","doi-asserted-by":"publisher","unstructured":"Koniger V, Holsten L, Harrison U, Busch B, Loell E, Bonsor DA, Roth A, Kengmo-Tchoupa A, Smith SI, Mueller S, Sundberg EJ, Zimmermann W, Fischer W, Hauck CR, Haas R (2016) H. pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nat Microbiol 2:16188. https:\/\/doi.org\/10.1038\/nmicrobiol.2016.188","DOI":"10.1038\/nmicrobiol.2016.188"},{"issue":"7","key":"8_CR86","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1002\/2211-5463.12225","volume":"7","author":"N Kumar","year":"2017","unstructured":"Kumar N, Shariq M, Kumar A, Kumari R, Subbarao N, Tyagi RK, Mukhopadhyay G (2017) Analyzing the role of CagV, a VirB8 homolog of the type IV secretion system of Helicobacter pylori. FEBS Open Bio 7(7):915\u2013933. https:\/\/doi.org\/10.1002\/2211-5463.12225","journal-title":"FEBS Open Bio"},{"issue":"3","key":"8_CR87","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/1873-3468.12564","volume":"591","author":"R Kumari","year":"2017","unstructured":"Kumari R, Shariq M, Kumar N, Mukhopadhyay G (2017) Biochemical characterization of the H. pylori cag-type IV secretion system unique component CagU. FEBS Lett 591(3):500\u2013512. https:\/\/doi.org\/10.1002\/1873-3468.12564","journal-title":"FEBS Lett"},{"issue":"6","key":"8_CR88","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1128\/JB.01341-07","volume":"190","author":"S Kutter","year":"2008","unstructured":"Kutter S, Buhrdorf R, Schneider-Brachert W, Haas R, Fischer W (2008) Protein subassemblies of the H. pylori cag type IV secretion system revealed by localization and interaction studies. J Bacteriol 190(6):2161\u20132171. https:\/\/doi.org\/10.1128\/JB.01341-07","journal-title":"J Bacteriol"},{"issue":"7164","key":"8_CR89","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nature06187","volume":"449","author":"T Kwok","year":"2007","unstructured":"Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, K\u00f6nig W, Backert S (2007) Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 449(7164):862\u2013866. https:\/\/doi.org\/10.1038\/nature06187","journal-title":"Nature"},{"issue":"21","key":"8_CR90","doi-asserted-by":"publisher","first-page":"16042","DOI":"10.1074\/jbc.M110.111054","volume":"285","author":"IO Lee","year":"2010","unstructured":"Lee IO, Kim JH, Choi YJ, Pillinger MH, Kim SY, Blaser MJ, Lee YC (2010) H. pylori CagA phosphorylation status determines the gp130-activated SHP2\/ERK and JAK\/STAT signal transduction pathways in gastric epithelial cells. J Biol Chem 285(21):16042\u201316050. https:\/\/doi.org\/10.1074\/jbc.M110.111054","journal-title":"J Biol Chem"},{"issue":"2","key":"8_CR91","doi-asserted-by":"publisher","first-page":"e30786","DOI":"10.1371\/journal.pone.0030786","volume":"7","author":"KS Lee","year":"2012","unstructured":"Lee KS, Kalantzis A, Jackson CB, O\u2019Connor L, Murata-Kamiya N, Hatakeyama M, Judd LM, Giraud AS, Menheniott TR (2012) Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3\u03b3 via gastric STAT3 activation. PLoS One 7(2):e30786. https:\/\/doi.org\/10.1371\/journal.pone.0030786","journal-title":"PLoS One"},{"key":"8_CR92","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.89","author":"MCC Lim","year":"2017","unstructured":"Lim MCC, Maubach G, Sokolova O, Feige MH, Diezko R, Buchbinder J, Backert S, Schl\u00fcter D, Lavrik IN, Naumann M (2017) Pathogen-induced ubiquitin editing enzyme A20 bifunctionally shuts off NF-\u03baB and caspase 8-dependent apoptotic cell death. Cell Death Differ. https:\/\/doi.org\/10.1038\/cdd.2017.89","journal-title":"Cell Death Differ"},{"issue":"5","key":"8_CR93","doi-asserted-by":"publisher","first-page":"e96488","DOI":"10.1371\/journal.pone.0096488","volume":"9","author":"J Lind","year":"2014","unstructured":"Lind J, Backert S, Pfleiderer K, Berg DE, Yamaoka Y, Sticht H, Tegtmeyer N (2014) Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains. PLoS One 9(5):e96488. https:\/\/doi.org\/10.1371\/journal.pone.0096488","journal-title":"PLoS One"},{"issue":"1","key":"8_CR94","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s12866-016-0820-6","volume":"16","author":"J Lind","year":"2016","unstructured":"Lind J, Backert S, Hoffmann R, Eichler J, Yamaoka Y, Perez-Perez GI, Torres J, Sticht H, Tegtmeyer N (2016) Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains. BMC Microbiol 16(1):201. https:\/\/doi.org\/10.1186\/s12866-016-0820-6","journal-title":"BMC Microbiol"},{"key":"8_CR95","doi-asserted-by":"crossref","unstructured":"Liu G, McDaniel TK, Falkow S, Karlin S (1999) Sequence anomalies in the Cag7 gene of the H. pylori pathogenicity island. Proc Natl Acad Sci USA 96(12):7011\u20137016","DOI":"10.1073\/pnas.96.12.7011"},{"issue":"1","key":"8_CR96","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1574-6968.2008.01368.x","volume":"289","author":"JT Loh","year":"2008","unstructured":"Loh JT, Torres VJ, Algood HM, McClain MS, Cover TL (2008) Helicobacter pylori HopQ outer membrane protein attenuates bacterial adherence to gastric epithelial cells. FEMS Microbiol Lett 289(1):53\u201358","journal-title":"FEMS Microbiol Lett"},{"issue":"7497","key":"8_CR97","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nature13081","volume":"508","author":"HH Low","year":"2014","unstructured":"Low HH, Gubellini F, Rivera-Calzada A, Braun N, Connery S, Dujeancourt A, Lu F, Redzej A, Fronzes R, Orlova EV, Waksman G (2014) Structure of a type IV secretion system. Nature 508(7497):550\u2013553. https:\/\/doi.org\/10.1038\/nature13081","journal-title":"Nature"},{"issue":"10","key":"8_CR98","doi-asserted-by":"publisher","first-page":"4954","DOI":"10.1091\/mbc.E05-05-0426","volume":"16","author":"H Lu","year":"2005","unstructured":"Lu H, Wu JY, Kudo T, Ohno T, Graham DY, Yamaoka Y (2005) Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with H. pylori. Mol Biol Cell 16(10):4954\u20134966. https:\/\/doi.org\/10.1091\/mbc.E05-05-0426","journal-title":"Mol Biol Cell"},{"issue":"1","key":"8_CR99","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.bbrc.2014.09.028","volume":"453","author":"G Lv","year":"2014","unstructured":"Lv G, Zhu H, Zhou F, Lin Z, Lin G, Li C (2014) AMP-activated protein kinase activation protects gastric epithelial cells from H. pylori-induced apoptosis. Biochem Biophys Res Commun 453(1):13\u201318. https:\/\/doi.org\/10.1016\/j.bbrc.2014.09.028","journal-title":"Biochem Biophys Res Commun"},{"key":"8_CR100","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s00262-014-1550-y","volume":"63","author":"L Miao","year":"2014","unstructured":"Miao L, Liu K, Xie M, Xing Y, Xi T (2014) miR-375 inhibits H. pylori-induced gastric carcinogenesis by blocking JAK2-STAT3 signaling. Cancer Immunol Immunother 63:699\u2013711. https:\/\/doi.org\/10.1007\/s00262-014-1550-y","journal-title":"Cancer Immunol Immunother"},{"issue":"2","key":"8_CR005","doi-asserted-by":"publisher","first-page":"e1006224","DOI":"10.1371\/journal.ppat.1006224","volume":"13","author":"Milica Milivojevic","year":"2017","unstructured":"Milivojevic M, Dangeard AS, Kasper CA, Tschon T, Emmenlauer M, Pique C, Schnupf P, Guignot J, Arrieumerlou C, Philpott DJ (2017) ALPK1 controls TIFA\/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria. PLOS Pathog 13(2):e1006224","journal-title":"PLOS Pathogens"},{"issue":"4","key":"8_CR101","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.chom.2007.09.005","volume":"2","author":"H Mimuro","year":"2007","unstructured":"Mimuro H, Suzuki T, Rieder G, Suzuki M, Nagai T, Fujita Y, Nagamatsu K, Ishijima N, Koyasu S, Haas R, Sasakawa C (2007) H. pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host Microbe 2(4):250\u2013263. https:\/\/doi.org\/10.1016\/j.chom.2007.09.005","journal-title":"Cell Host Microbe"},{"issue":"4","key":"8_CR007","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/1615-9861(200104)1:4<618::AID-PROT618>3.0.CO;2-C","volume":"1","author":"Stefan Moese","year":"2001","unstructured":"Moese S, Selbach M, Zimny-Arndt U, Jungblut PR, Meyer TF, Backert S (2001) Identification of a tyrosine-phosphorylated 35 kDa carboxy-terminal fragment (p35CagA) of the Helicobacter pylori CagA protein in phagocytic cells: processing or breakage? Proteomics 1(4):618\u2013629","journal-title":"PROTEOMICS"},{"key":"8_CR102","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1159\/000235763","volume":"6","author":"Y Moodley","year":"2009","unstructured":"Moodley Y, Linz B (2009) H. pylori sequences reflect past human migrations. Genome Dyn 6:62\u201374. https:\/\/doi.org\/10.1159\/000235763","journal-title":"Genome Dyn"},{"issue":"4","key":"8_CR103","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1172\/JCI61143","volume":"122","author":"D Mueller","year":"2012","unstructured":"Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S, Torres J, Smolka A, Backert S (2012) c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest 122(4):1553\u20131566. https:\/\/doi.org\/10.1172\/JCI61143","journal-title":"J Clin Invest"},{"issue":"5","key":"8_CR104","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.chom.2010.04.005","volume":"7","author":"N Murata-Kamiya","year":"2010","unstructured":"Murata-Kamiya N, Kikuchi K, Hayashi T, Higashi H, Hatakeyama M (2010) H. pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of CagA. Cell Host Microbe 7(5):399\u2013411. https:\/\/doi.org\/10.1016\/j.chom.2010.04.005","journal-title":"Cell Host Microbe"},{"issue":"32","key":"8_CR105","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.1038\/sj.onc.1210251","volume":"26","author":"N Murata-Kamiya","year":"2007","unstructured":"Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, Aburatani H, Akiyama T, Peek RM Jr, Azuma T, Hatakeyama M (2007) H. pylori CagA interacts with E-cadherin and deregulates catenin that promotes intestinal transdifferentiation in cells. Oncogene 26(32):4617\u20134626. https:\/\/doi.org\/10.1038\/sj.onc.1210251","journal-title":"Oncogene"},{"issue":"5298","key":"8_CR106","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1126\/science.275.5298.400","volume":"275","author":"AM Musti","year":"1997","unstructured":"Musti AM, Treier M, Bohmann D (1997) Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. Science 275(5298):400\u2013402","journal-title":"Science"},{"issue":"4","key":"8_CR107","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.tim.2016.12.004","volume":"25","author":"M Naumann","year":"2017","unstructured":"Naumann M, Sokolova O, Tegtmeyer N, Backert S (2017) Helicobacter pylori: a paradigm pathogen for subverting host cell signal transmission. Trends Microbiol 25(4):316\u2013328. https:\/\/doi.org\/10.1016\/j.tim.2016.12.004","journal-title":"Trends Microbiol"},{"issue":"44","key":"8_CR108","doi-asserted-by":"publisher","first-page":"31655","DOI":"10.1074\/jbc.274.44.31655","volume":"274","author":"M Naumann","year":"1999","unstructured":"Naumann M, Wessler S, Bartsch C, Wieland B, Covacci A, Haas R, Meyer TF (1999) Activation of activator protein 1 and stress response kinases in epithelial cells colonized by H. pylori encoding the cag pathogenicity island. J Biol Chem 274(44):31655\u201331662","journal-title":"J Biol Chem"},{"issue":"11","key":"8_CR110","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1096\/fj.06-7615rev","volume":"21","author":"M Neumann","year":"2007","unstructured":"Neumann M, Naumann M (2007) Beyond I\u03baBs: alternative regulation of NF-\u03baB activity. FASEB J 21(11):2642\u20132654. https:\/\/doi.org\/10.1096\/fj.06-7615rev","journal-title":"FASEB J"},{"issue":"1","key":"8_CR111","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1172\/JCI64373","volume":"123","author":"JM Noto","year":"2013","unstructured":"Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM Jr (2013) Iron deficiency accelerates H. pylori-induced carcinogenesis in rodents and humans. J Clin Invest 123(1):479\u2013492. https:\/\/doi.org\/10.1172\/JCI64373","journal-title":"J Clin Invest"},{"issue":"5457","key":"8_CR112","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1126\/science.287.5457.1497","volume":"287","author":"S Odenbreit","year":"2000","unstructured":"Odenbreit S, P\u00fcls J, Sedlmaier B, Gerland E, Haas R (2000) Translocation of H. pylori CagA into gastric epithelial cells by type IV secretion. Science 287(5457):1497\u20131500","journal-title":"Science"},{"issue":"9","key":"8_CR113","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1128\/IAI.00364-09","volume":"77","author":"S Odenbreit","year":"2009","unstructured":"Odenbreit S, Swoboda K, Barwig I, Ruhl S, Bor\u00e9n T, Koletzko S, Haas R (2009) Outer membrane protein expression profile in H. pylori clinical isolates. Infect Immun 77(9):3782\u20133790. https:\/\/doi.org\/10.1128\/IAI.00364-09","journal-title":"Infect Immun"},{"issue":"10","key":"8_CR114","doi-asserted-by":"publisher","first-page":"4110","DOI":"10.1091\/mbc.E08-03-0283","volume":"19","author":"SR Ogden","year":"2008","unstructured":"Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O\u2019Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM Jr (2008) p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol Biol Cell 19(10):4110\u20134121. https:\/\/doi.org\/10.1091\/mbc.E08-03-0283","journal-title":"Mol Biol Cell"},{"key":"8_CR115","doi-asserted-by":"publisher","unstructured":"Ohnishi N, Yuasa H, Tanaka S, Sawa H, Miura M, Matsui A, Higashi H, Musashi M, Iwabuchi K, Suzuki M, Yamada G, Azuma T, Hatakeyama M (2008) Transgenic expression of H. pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci USA 105(3):1003\u20131008. https:\/\/doi.org\/10.1073\/pnas.0711183105","DOI":"10.1073\/pnas.0711183105"},{"issue":"8","key":"8_CR116","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nrclinonc.2011.45","volume":"8","author":"A Okines","year":"2011","unstructured":"Okines A, Cunningham D, Chau I (2011) Targeting the human EGFR family in esophagogastric cancer. Nat Rev Clin Oncol 8(8):492\u2013503. https:\/\/doi.org\/10.1038\/nrclinonc.2011.45","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"8_CR117","doi-asserted-by":"publisher","first-page":"e1001069","DOI":"10.1371\/journal.pgen.1001069","volume":"6","author":"P Olbermann","year":"2010","unstructured":"Olbermann P, Josenhans C, Moodley Y, Uhr M, Stamer C, Vauterin M, Suerbaum S, Achtman M, Linz B (2010) A global overview of the genetic and functional diversity in the H. pylori cag pathogenicity island. PLoS Genet 6(8):e1001069. https:\/\/doi.org\/10.1371\/journal.pgen.1001069","journal-title":"PLoS Genet"},{"issue":"46","key":"8_CR118","doi-asserted-by":"publisher","first-page":"34888","DOI":"10.1074\/jbc.M607067200","volume":"281","author":"MJ Oliveira","year":"2006","unstructured":"Oliveira MJ, Costa AC, Costa AM, Henriques L, Suriano G, Atherton JC, Machado JC, Carneiro F, Seruca R, Mareel M, Leroy A, Figueiredo C (2006) H. pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner. J Biol Chem 281(46):34888\u201334896. https:\/\/doi.org\/10.1074\/jbc.M607067200","journal-title":"J Biol Chem"},{"issue":"5","key":"8_CR119","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1086\/604727","volume":"200","author":"MJ Oliveira","year":"2009","unstructured":"Oliveira MJ, Costa AM, Costa AC, Ferreira RM, Sampaio P, Machado JC, Seruca R, Mareel M, Figueiredo C (2009) CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses H. pylori-induced cell-invasive phenotype. J Infect Dis 200(5):745\u2013755. https:\/\/doi.org\/10.1086\/604727","journal-title":"J Infect Dis"},{"issue":"2","key":"8_CR121","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1128\/JCM.01456-06","volume":"45","author":"OA Oyarzabal","year":"2007","unstructured":"Oyarzabal OA, Rad R, Backert S (2007) Conjugative transfer of chromosomally encoded antibiotic resistance from Helicobacter pylori to Campylobacter jejuni. J Clin Microbiol 45(2):402\u2013408","journal-title":"J Clin Microbiol"},{"key":"8_CR122","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-3-319-41171-2_6","volume":"397","author":"SK Pachathundikandi","year":"2016","unstructured":"Pachathundikandi SK, M\u00fcller A, Backert S (2016) Inflammasome activation by Helicobacter pylori and its implications for persistence and immunity. Curr Top Microbiol Immunol 397:117\u2013131. https:\/\/doi.org\/10.1007\/978-3-319-41171-2_6","journal-title":"Curr Top Microbiol Immunol"},{"issue":"3","key":"8_CR123","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1136\/gut.40.3.297","volume":"40","author":"J Parsonnet","year":"1997","unstructured":"Parsonnet J, Friedman GD, Orentreich N, Vogelman H (1997) Risk for gastric cancer in people with CagA positive or CagA negative H. pylori infection. Gut 40(3):297\u2013301","journal-title":"Gut"},{"issue":"Pt 9","key":"8_CR124","doi-asserted-by":"publisher","first-page":"2896","DOI":"10.1099\/mic.0.2007\/007385-0","volume":"153","author":"I Pattis","year":"2007","unstructured":"Pattis I, Weiss E, Laugks R, Haas R, Fischer W (2007) The H. pylori CagF protein is a type IV chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein. Microbiology 153(Pt 9):2896\u20132909. https:\/\/doi.org\/10.1099\/mic.0.2007\/007385-0","journal-title":"Microbiology"},{"issue":"4","key":"8_CR125","doi-asserted-by":"publisher","first-page":"e35341","DOI":"10.1371\/journal.pone.0035341","volume":"7","author":"KT Pham","year":"2012","unstructured":"Pham KT, Weiss E, Jim\u00e9nez Soto LF, Breithaupt U, Haas R, Fischer W (2012) CagI is an essential component of the H. pylori Cag type IV secretion system and forms a complex with CagL. PLoS One 7(4):e35341. https:\/\/doi.org\/10.1371\/journal.pone.0035341","journal-title":"PLoS One"},{"issue":"23","key":"8_CR126","doi-asserted-by":"publisher","first-page":"7343","DOI":"10.1128\/JB.00946-09","volume":"191","author":"DM Pinto-Santini","year":"2009","unstructured":"Pinto-Santini DM, Salama NR (2009) Cag3 is a novel essential component of the H. pylori Cag type IV secretion system outer membrane subcomplex. J Bacteriol 191(23):7343\u20137352. https:\/\/doi.org\/10.1128\/JB.00946-09","journal-title":"J Bacteriol"},{"issue":"1","key":"8_CR127","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1074\/jbc.M003819200","volume":"276","author":"T Pomorski","year":"2001","unstructured":"Pomorski T, Meyer TF, Naumann M (2001) H. pylori-induced prostaglandin E(2) synthesis involves activation of cytosolic phospholipase A(2) in epithelial cells. J Biol Chem 276(1):804\u2013810. https:\/\/doi.org\/10.1074\/jbc.M003819200","journal-title":"J Biol Chem"},{"issue":"24","key":"8_CR128","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.1038\/sj.onc.1210139","volume":"26","author":"M Poppe","year":"2007","unstructured":"Poppe M, Feller SM, R\u00f6mer G, Wessler S (2007) Phosphorylation of H. pylori CagA by c-Abl leads to cell motility. Oncogene 26(24):3462\u20133472. https:\/\/doi.org\/10.1038\/sj.onc.1210139","journal-title":"Oncogene"},{"issue":"3","key":"8_CR129","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1096\/fj.14-257501","volume":"29","author":"S Rath","year":"2015","unstructured":"Rath S, Das L, Kokate SB, Pratheek BM, Chattopadhyay S, Goswami C, Chattopadhyay R, Crowe SE, Bhattacharyya A (2015) Regulation of Noxa-mediated apoptosis in H. pylori-infected gastric epithelial cells. FASEB J 29(3):796\u2013806. https:\/\/doi.org\/10.1096\/fj.14-257501","journal-title":"FASEB J"},{"issue":"4","key":"8_CR131","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1515\/BC.2011.029","volume":"392","author":"C Rieke","year":"2011","unstructured":"Rieke C, Papendieck A, Sokolova O, Naumann M (2011) H. pylori-induced tyrosine phosphorylation of IKK\u03b2 contributes to NF-\u03baB activation. Biol Chem 392(4):387\u2013393. https:\/\/doi.org\/10.1515\/BC.2011.029","journal-title":"Biol Chem"},{"issue":"1","key":"8_CR132","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.1365-2958.2003.03549.x","volume":"49","author":"M Rohde","year":"2003","unstructured":"Rohde M, P\u00fcls J, Buhrdorf R, Fischer W, Haas R (2003) A novel sheathed surface organelle of the H. pylori cag type IV secretion system. Mol Microbiol 49(1):219\u2013234","journal-title":"Mol Microbiol"},{"issue":"9","key":"8_CR133","doi-asserted-by":"publisher","first-page":"e45623","DOI":"10.1371\/journal.pone.0045623","volume":"7","author":"S Rohrer","year":"2012","unstructured":"Rohrer S, Holsten L, Weiss E, Benghezal M, Fischer W, Haas R (2012) Multiple pathways of plasmid DNA transfer in Helicobacter pylori. PLoS ONE 7(9):e45623. https:\/\/doi.org\/10.1371\/journal.pone.0045623","journal-title":"PLoS ONE"},{"key":"8_CR134","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.phrs.2013.11.002","volume":"79","author":"R Roskoski Jr","year":"2014","unstructured":"Roskoski R Jr (2014) The ErbB\/HER family of protein-tyrosine kinases and cancer. Pharmacol Res 79:34\u201374. https:\/\/doi.org\/10.1016\/j.phrs.2013.11.002","journal-title":"Pharmacol Res"},{"issue":"7142","key":"8_CR135","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nature05765","volume":"447","author":"Iraj Saadat","year":"2007","unstructured":"Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, Ohno S, Hatakeyama M (2007) H. pylori CagA targets PAR1\/MARK kinase to disrupt epithelial cell polarity. Nature 447(7142):330\u2013333. https:\/\/doi.org\/10.1038\/nature05765","journal-title":"Nature"},{"issue":"1","key":"8_CR136","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1053\/j.gastro.2010.03.036","volume":"139","author":"A Saha","year":"2010","unstructured":"Saha A, Backert S, Hammond CE, Gooz M, Smolka AJ (2010) Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H. K-ATPase alpha subunit. Gastroenterology 139(1):239\u2013248. https:\/\/doi.org\/10.1053\/j.gastro.2010.03.036","journal-title":"K-ATPase alpha subunit. Gastroenterology"},{"key":"8_CR137","doi-asserted-by":"publisher","first-page":"16026","DOI":"10.1038\/nmicrobiol.2016.26","volume":"1","author":"P Saju","year":"2016","unstructured":"Saju P, Murata-Kamiya N, Hayashi T, Senda Y, Nagase L, Noda S, Matsusaka K, Funata S, Kunita A, Urabe M, Seto Y, Fukayama M, Kaneda A, Hatakeyama M (2016) Host SHP1 phosphatase antagonizes H. pylori CagA and can be downregulated by Epstein-Barr virus. Nature Microbiol 1:16026. https:\/\/doi.org\/10.1038\/nmicrobiol.2016.26","journal-title":"Nature Microbiol"},{"issue":"6","key":"8_CR138","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrmicro3016","volume":"11","author":"NR Salama","year":"2013","unstructured":"Salama NR, Hartung ML, M\u00fcller A (2013) Life in the human stomach: persistence strategies of the bacterial pathogen H. pylori. Nat Rev Microbiol 11(6):385\u2013399. https:\/\/doi.org\/10.1038\/nrmicro3016","journal-title":"Nat Rev Microbiol"},{"key":"8_CR139","doi-asserted-by":"publisher","unstructured":"Sause WE, Keilberg D, Aboulhouda S, Ottemann KM (2017) The H. pylori autotransporter ImaA tempers the bacterium\u2019s interaction with alpha5beta1 integrin. Infect Immun 85(1):pii: e00450-16. https:\/\/doi.org\/10.1128\/iai.00450-16","DOI":"10.1128\/iai.00450-16"},{"key":"8_CR140","doi-asserted-by":"publisher","first-page":"23264","DOI":"10.1038\/srep23264","volume":"6","author":"TP Schmidt","year":"2016","unstructured":"Schmidt TP, Perna AM, Fugmann T, B\u00f6hm M, Hiss Jan, Haller S, G\u00f6tz C, Tegtmeyer N, Hoy B, Rau TT, Neri D, Backert S, Schneider G, Wessler S (2016) Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA. Sci Rep 6:23264. https:\/\/doi.org\/10.1038\/srep23264","journal-title":"Sci Rep"},{"issue":"1","key":"8_CR141","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/embor.2009.263","volume":"11","author":"K Schweitzer","year":"2010","unstructured":"Schweitzer K, Sokolova O, Bozko P, Naumann M (2010) H. pylori induces NF-\u0138B independent of CagA. EMBO Rep 11(1):10\u201311. https:\/\/doi.org\/10.1038\/embor.2009.263","journal-title":"EMBO Rep"},{"key":"8_CR142","doi-asserted-by":"crossref","unstructured":"Segal ED, Cha J, Lo J, Falkow S, Tompkins LS (1999) Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by H. pylori. Proc Natl Acad Sci USA 96(25):14559\u201314564","DOI":"10.1073\/pnas.96.25.14559"},{"issue":"9","key":"8_CR143","doi-asserted-by":"publisher","first-page":"6775","DOI":"10.1074\/jbc.C100754200","volume":"277","author":"M Selbach","year":"2002","unstructured":"Selbach M, Moese S, Hauck CR, Meyer TF, Backert S (2002) Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 277(9):6775\u20136778. https:\/\/doi.org\/10.1074\/jbc.C100754200","journal-title":"J Biol Chem"},{"issue":"4","key":"8_CR144","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.chom.2009.03.004","volume":"5","author":"M Selbach","year":"2009","unstructured":"Selbach M, Paul FE, Brandt S, Guye P, Daumke O, Backert S, Dehio C, Mann M (2009) Host cell interactome of tyrosine-phosphorylated bacterial proteins. Cell Host Microbe 5(4):397\u2013403","journal-title":"Cell Host Microbe"},{"issue":"7","key":"8_CR145","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/cas.12962","volume":"107","author":"Y Senda","year":"2016","unstructured":"Senda Y, Murata-Kamiya N, Hatakeyama M (2016) C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility. Cancer Sci 107(7):972\u2013980. https:\/\/doi.org\/10.1111\/cas.12962","journal-title":"Cancer Sci"},{"issue":"9","key":"8_CR146","doi-asserted-by":"publisher","first-page":"e1002237","DOI":"10.1371\/journal.ppat.1002237","volume":"7","author":"CL Shaffer","year":"2011","unstructured":"Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, McClain MS, McDonald WH, Cover TL (2011) H. pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog 7(9):e1002237. https:\/\/doi.org\/10.1371\/journal.ppat.1002237","journal-title":"PLoS Pathog"},{"issue":"3","key":"8_CR147","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/j.1751-2980.2009.00380.x","volume":"10","author":"AM Shanks","year":"2009","unstructured":"Shanks AM, El-Omar EM (2009) H. pylori infection, host genetics and gastric cancer. J Dig Dis 10(3):157\u2013164. https:\/\/doi.org\/10.1111\/j.1751-2980.2009.00380.x","journal-title":"J Dig Dis"},{"issue":"11","key":"8_CR148","doi-asserted-by":"publisher","first-page":"e0142606","DOI":"10.1371\/journal.pone.0142606","volume":"10","author":"M Shariq","year":"2015","unstructured":"Shariq M, Kumar N, Kumari R, Kumar A, Subbarao N, Mukhopadhyay G (2015) Biochemical analysis of CagE: a VirB4 homologue of H. pylori Cag-T4SS. PLoS One 10(11):e0142606. https:\/\/doi.org\/10.1371\/journal.pone.0142606","journal-title":"PLoS One"},{"key":"8_CR149","unstructured":"Sierra JC, Asim M, Verriere TG, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado AG, Wroblewski LE, Barry DP, Peek RM Jr, Gobert AP, Wilson KT (2017) Epidermal growth factor receptor inhibition downregulates H. pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut pii: gutjnl-2016-312888"},{"issue":"4","key":"8_CR150","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.molcel.2011.09.015","volume":"44","author":"B Skaug","year":"2011","unstructured":"Skaug B, Chen J, Du F, He J, Ma A, Chen ZJ (2011) Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell 44(4):559\u2013571. https:\/\/doi.org\/10.1016\/j.molcel.2011.09.015","journal-title":"Mol Cell"},{"key":"8_CR151","doi-asserted-by":"publisher","unstructured":"Smart J, Fouillen A, Casu B, Nanci A, Baron C (2017) Cag-delta (Cag3) protein from the H. pylori 26695 cag type IV secretion system forms ring-like supramolecular assemblies. FEMS Microbiol Lett 364(1): pii: fnw280. https:\/\/doi.org\/10.1093\/femsle\/fnw280","DOI":"10.1093\/femsle\/fnw280"},{"issue":"20","key":"8_CR152","doi-asserted-by":"publisher","first-page":"13952","DOI":"10.1074\/jbc.M800289200","volume":"283","author":"JL Snider","year":"2008","unstructured":"Snider JL, Allison C, Bellaire BH, Ferrero RL, Cardelli JA (2008) The beta1 integrin activates JNK independent of CagA, and JNK activation is required for H. pylori CagA-induced motility of gastric cancer cells. J Biol Chem 283(20):13952\u201313963. https:\/\/doi.org\/10.1074\/jbc.M800289200","journal-title":"J Biol Chem"},{"issue":"8","key":"8_CR153","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.ijmm.2013.07.008","volume":"303","author":"O Sokolova","year":"2013","unstructured":"Sokolova O, Borgmann M, Schweitzer K, Rothk\u00f6tter HJ, Naumann M (2013) H. pylori induces type 4 secretion system-dependent, but CagA-independent activation of I\u03baBs and NF-\u03baB\/RelA at early time points. Int J Med Microbiol 303(8):548\u2013552. https:\/\/doi.org\/10.1016\/j.ijmm.2013.07.008","journal-title":"Int J Med Microbiol"},{"issue":"43","key":"8_CR154","doi-asserted-by":"publisher","first-page":"29367","DOI":"10.1074\/jbc.M801818200","volume":"283","author":"O Sokolova","year":"2008","unstructured":"Sokolova O, Bozko PM, Naumann M (2008) H. pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity. J Biol Chem 283(43):29367\u201329374. https:\/\/doi.org\/10.1074\/jbc.M801818200","journal-title":"J Biol Chem"},{"issue":"4","key":"8_CR155","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.bbamcr.2014.01.006","volume":"1843","author":"O Sokolova","year":"2014","unstructured":"Sokolova O, Maubach G, Naumann M (2014) MEKK3 and TAK1 synergize to activate IKK complex in H. pylori infection. Biochim Biophys Acta 1843(4):715\u2013724. https:\/\/doi.org\/10.1016\/j.bbamcr.2014.01.006","journal-title":"Biochim Biophys Acta"},{"key":"8_CR156","unstructured":"Stein M, Rappuoli R, Covacci A (2000) Tyrosine phosphorylation of the H. pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci USA 97(3):1263\u20131268"},{"issue":"4","key":"8_CR157","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1046\/j.1365-2958.2002.02781.x","volume":"43","author":"M Stein","year":"2002","unstructured":"Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, Covacci A (2002) c-Src\/Lyn kinases activate H. pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 43(4):971\u2013980","journal-title":"Mol Microbiol"},{"issue":"7","key":"8_CR158","doi-asserted-by":"publisher","first-page":"e1006514","DOI":"10.1371\/journal.ppat.1006514","volume":"13","author":"SC Stein","year":"2017","unstructured":"Stein SC, Faber E, Bats SH, Murillo T, Speidel Y, Coombs N, Josenhans C (2017) Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis. PLoS Pathog 13(7):e1006514. https:\/\/doi.org\/10.1371\/journal.ppat.1006514","journal-title":"PLoS Pathog"},{"issue":"4","key":"8_CR159","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1053\/j.gastro.2007.01.050","volume":"132","author":"I Tammer","year":"2007","unstructured":"Tammer I, Brandt S, Hartig R, K\u00f6nig W, Backert S (2007) Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology 132(4):1309\u20131319. https:\/\/doi.org\/10.1053\/j.gastro.2007.01.050","journal-title":"Gastroenterology"},{"issue":"6","key":"8_CR160","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1046\/j.1462-5822.2003.00286.x","volume":"5","author":"J Tanaka","year":"2003","unstructured":"Tanaka J, Suzuki T, Mimuro H, Sasakawa C (2003) Structural definition on the surface of H. pylori type IV secretion apparatus. Cell Microbiol 5(6):395\u2013404","journal-title":"Cell Microbiol"},{"issue":"43","key":"8_CR161","doi-asserted-by":"publisher","first-page":"32714","DOI":"10.1074\/jbc.M603126200","volume":"281","author":"B Tanos","year":"2006","unstructured":"Tanos B, Pendergast AM (2006) Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor. J Biol Chem 281(43):32714\u201332723. https:\/\/doi.org\/10.1074\/jbc.M603126200","journal-title":"J Biol Chem"},{"issue":"30","key":"8_CR04","doi-asserted-by":"publisher","first-page":"23515","DOI":"10.1074\/jbc.M109.096214","volume":"285","author":"Nicole Tegtmeyer","year":"2010","unstructured":"Tegtmeyer N, Hartig R, Delahay RM, Rohde M, Brandt S, Conradi J, Takahashi S, Smolka AJ, Sewald N, Backert S (2010) A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. J Biol Chem 285(30):23515\u201323526. https:\/\/doi.org\/10.1074\/jbc.M109.096214","journal-title":"Journal of Biological Chemistry"},{"issue":"8","key":"8_CR162","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1111\/j.1742-4658.2011.08035.x","volume":"278","author":"Nicole Tegtmeyer","year":"2011","unstructured":"Tegtmeyer N, Wessler S, Backert S (2011a) Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J 278(8):1190\u20131202. https:\/\/doi.org\/10.1111\/j.1742-4658.2011.08035.x","journal-title":"FEBS Journal"},{"issue":"3","key":"8_CR163","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1462-5822.2008.01269.x","volume":"11","author":"N Tegtmeyer","year":"2009","unstructured":"Tegtmeyer N, Zabler D, Schmidt D, Hartig R, Brandt S, Backert S (2009) Importance of EGF receptor, HER2\/Neu and Erk1\/2 kinase signaling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cell Microbiol 11(3):488\u2013505. https:\/\/doi.org\/10.1111\/j.1462-5822.2008.01269.x","journal-title":"Cell Microbiol"},{"key":"8_CR164","doi-asserted-by":"publisher","unstructured":"Tegtmeyer N, Wessler S, Necchi V, Rohde M, Harrer A, Rau TT, Asche CI, Boehm M, Loessner M, Figueiredo C, Naumann M, Palmisano R, Solcia E, Ricci V, Backert S (2017) A unique basolateral type IV secretion model for the CagA oncoprotein of Helicobacter pylori. Cell Host Microbe 22(4):552\u2013560.e5. https:\/\/doi.org\/10.1016\/j.chom.2017.09.005","DOI":"10.1016\/j.chom.2017.09.005"},{"key":"8_CR165","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.chom.2011.05.007","volume":"9","author":"N Tegtmeyer","year":"2011","unstructured":"Tegtmeyer N, Wittelsberger R, Hartig R, Wessler S, Martinez-Quiles N, Backert S (2011b) Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. Cell Host Microbe 9:520\u2013531. https:\/\/doi.org\/10.1016\/j.chom.2011.05.007","journal-title":"Cell Host Microbe"},{"key":"8_CR166","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1038\/onc.2010.304","volume":"29","author":"YH Tsang","year":"2010","unstructured":"Tsang YH, Lamb A, Romero-Gallo J, Huang B, Ito K, Peek RM Jr, Ito Y, Chen LF (2010) H. pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation. Oncogene 29:5643\u20135650. https:\/\/doi.org\/10.1038\/onc.2010.304","journal-title":"Oncogene"},{"issue":"1\u20132","key":"8_CR167","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s11010-011-0899-x","volume":"357","author":"G Udhayakumar","year":"2011","unstructured":"Udhayakumar G, Jayanthi V, Devaraj N, Devaraj H (2011) Nuclear translocation of beta-catenin correlates with CD44 upregulation in H. pylori-infected gastric carcinoma. Mol Cell Biochem 357(1\u20132):283\u2013293. https:\/\/doi.org\/10.1007\/s11010-011-0899-x","journal-title":"Mol Cell Biochem"},{"issue":"48","key":"8_CR168","doi-asserted-by":"publisher","first-page":"6262","DOI":"10.1038\/onc.2016.158","volume":"35","author":"MG Varga","year":"2016","unstructured":"Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM (2016) Pathogenic H. pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Oncogene 35(48):6262\u20136269. https:\/\/doi.org\/10.1038\/onc.2016.158","journal-title":"Oncogene"},{"key":"8_CR169","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/ni1131","volume":"5","author":"J Viala","year":"2004","unstructured":"Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, Athman R, M\u00e9met S, Huerre MR, DiStefano PS, Sansonetti PJ, Labigne A, Bertin J, Philpott DJ, Ferrero RL (2004) Nod1 responds to peptidoglycan delivered by the H. pylori cag pathogenicity island. Nat Immunol 5:1166\u20131174. https:\/\/doi.org\/10.1038\/ni1131","journal-title":"Nat Immunol"},{"issue":"3","key":"8_CR170","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0006-291X(02)00740-4","volume":"295","author":"C Wallasch","year":"2002","unstructured":"Wallasch C, Crabtree JE, Bevec D, Robinson PA, Wagner H, Ullrich A (2002) H. pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF. Biochem Biophys Res Commun 295(3):695\u2013701","journal-title":"Biochem Biophys Res Commun"},{"key":"8_CR171","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/hel.12311","volume":"21","author":"XK Wan","year":"2016","unstructured":"Wan XK, Yuan SL, Wang YC, Tao HX, Jiang W, Guan ZY, Cao C, Liu CJ (2016) The upregulation of TRAF1 induced by H.pylori plays an antiapoptotic effect on the infected cells. Helicobacter 21:554\u2013564. https:\/\/doi.org\/10.1111\/hel.12311","journal-title":"Helicobacter"},{"key":"8_CR173","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12885-016-2138-z","volume":"16","author":"J Wang","year":"2016","unstructured":"Wang J, Goetsch L, Tucker L, Zhang Q, Gonzalez A, Vaidya KS, Oleksijew A, Song M, Sokolova I, Pestova E, Anderson M, Pappano WN, Ansell P, Bhathena A, Naumovski L, Corvaia N, Reilly EB (2016) Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC Cancer 16:105. https:\/\/doi.org\/10.1186\/s12885-016-2138-z","journal-title":"BMC Cancer"},{"issue":"3","key":"8_CR174","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/S0016-5085(98)70143-X","volume":"115","author":"T Watanabe","year":"1998","unstructured":"Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M (1998) H. pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology 115(3):642\u2013648","journal-title":"Gastroenterology"},{"issue":"16","key":"8_CR003","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1016\/j.yexcr.2007.07.015","volume":"313","author":"Christiane Weydig","year":"2007","unstructured":"Weydig C, Starzinski-Powitz A, Carra G, L\u00f6wer J, Wessler S (2007) CagA-independent disruption of adherence junction complexes involves Ecadherin shedding and implies multiple steps in Helicobacter pylori pathogenicity. Exp Cell Res 313(16):3459\u20133471","journal-title":"Experimental Cell Research"},{"key":"8_CR001","doi-asserted-by":"publisher","unstructured":"Wessler S, Backert S (2011) Abl family of tyrosine kinases and microbial pathogenesis. Int Rev Cell Mol Biol 286:271\u2013300. https:\/\/doi.org\/10.1016\/B978-0-12-385859-7.00006-9","DOI":"10.1016\/B978-0-12-385859-7.00006-9"},{"issue":"8","key":"8_CR175","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.tim.2008.05.005","volume":"16","author":"S Wessler","year":"2008","unstructured":"Wessler S, Backert S (2008) Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori. Trends Microbiol 16(8):397\u2013405. https:\/\/doi.org\/10.1016\/j.tim.2008.05.005","journal-title":"Trends Microbiol"},{"issue":"7","key":"8_CR176","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1136\/gutjnl-2011-300525","volume":"61","author":"T Wiedemann","year":"2012","unstructured":"Wiedemann T, Hofbaur S, Tegtmeyer N, Huber S, Sewald N, Wessler S, Backert S, Rieder G (2012) Helicobacter pylori CagL dependent induction of gastrin expression via a novel alphavbeta5-integrin-integrin linked kinase signaling complex. Gut 61(7):986\u2013996. https:\/\/doi.org\/10.1136\/gutjnl-2011-300525","journal-title":"Gut"},{"issue":"9","key":"8_CR177","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1046\/j.1365-2036.2001.01051.x","volume":"15","author":"BC Wong","year":"2001","unstructured":"Wong BC, Wang WP, So WH, Shin VY, Wong WM, Fung FM, Liu ES, Hiu WM, Lam SK, Cho CH (2001) Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after H. pylori eradication. Aliment Pharmacol Ther 15(9):1459\u20131465","journal-title":"Aliment Pharmacol Ther"},{"key":"8_CR178","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2217\/fon.14.29","volume":"10","author":"Y Yamaoka","year":"2014","unstructured":"Yamaoka Y, Graham DY (2014) H. pylori virulence and cancer pathogenesis. Future Oncol 10:1487\u20131500. https:\/\/doi.org\/10.2217\/fon.14.29","journal-title":"Future Oncol"},{"issue":"16","key":"8_CR179","doi-asserted-by":"publisher","first-page":"11250","DOI":"10.1074\/jbc.M509404200","volume":"281","author":"E Yamasaki","year":"2006","unstructured":"Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, Hisatsune J, Kimura M, Moss J, Hirayama T (2006) H. pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome-c release and cell death, independent of vacuolation. J Biol Chem 281(16):11250\u201311259. https:\/\/doi.org\/10.1074\/jbc.M509404200","journal-title":"J Biol Chem"},{"issue":"2","key":"8_CR180","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.canlet.2016.02.032","volume":"374","author":"X Yong","year":"2016","unstructured":"Yong X, Tang B, Xiao YF, Xie R, Qin Y, Luo G, Hu CJ, Dong H, Yang SM (2016) H. pylori upregulates Nanog and Oct4 via Wnt\/beta-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer. Cancer Lett 374(2):292\u2013303. https:\/\/doi.org\/10.1016\/j.canlet.2016.02.032","journal-title":"Cancer Lett"},{"issue":"5","key":"8_CR182","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/hel.12215","volume":"20","author":"SF Zaidi","year":"2015","unstructured":"Zaidi SF, Refaat A, Zhou Y, Sualeh Muhammad J, Shin MS, Saiki I, Sakurai H, Sugiyama T (2015) H. pylori induces serine phosphorylation of EGFR via novel TAK1-p38 activation pathway in an HB-EGF-independent manner. Helicobacter 20(5):381\u2013389. https:\/\/doi.org\/10.1111\/hel.12215","journal-title":"Helicobacter"},{"key":"8_CR183","doi-asserted-by":"publisher","unstructured":"Zhang J, Fan F, Zhao Y, Sun L, Liu Y, Keegan RM, Isupov MN, Wu Y (2017) Crystal structure of the type IV secretion system component CagX from H. pylori. Acta Crystallogr F Struct Biol Commun 73(Pt 3):167\u2013173. https:\/\/doi.org\/10.1107\/s2053230x17001376","DOI":"10.1107\/s2053230x17001376"},{"issue":"7","key":"8_CR03","doi-asserted-by":"publisher","first-page":"G606","DOI":"10.1152\/ajpgi.00333.2013","volume":"306","author":"Yong-Mei Zhang","year":"2014","unstructured":"Zhang YM, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RMJr, Smolka AJ (2014) Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase \u03b1-subunit gene expression by miRNA. Am J Physiol Gastrointest Liver Physiol 306(7):G606\u2013613. https:\/\/doi.org\/10.1152\/ajpgi.00333.2013","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"8_CR184","doi-asserted-by":"publisher","unstructured":"Zimmermann S, Pfannkuch L, Al-Zeer M, Bartfeld S, Koch M, Liu J, Rechner C, Soerensen M, Sokolova O, Zamyatina A, Kosma P, Maeurer AP, Glowinski F, Pleissner KP, Schmid M, Brinkmann V, Naumann M, Rother M, Machuy N, Meyer TF (2017) ALPK1 and TIFA dependent innate immune response triggered By The H. pylori type IV secretion system. Cell Rep 20(10):2384\u20132395. https:\/\/doi.org\/10.1101\/139998","DOI":"10.1101\/139998"}],"container-title":["Current Topics in Microbiology and Immunology","Type IV Secretion in Gram-Negative and Gram-Positive Bacteria"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-75241-9_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:41:44Z","timestamp":1693582904000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-75241-9_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319752402","9783319752419"],"references-count":191,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-75241-9_8","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}