{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:35:36Z","timestamp":1790627736684,"version":"4.1.0"},"publisher-location":"Cham","reference-count":41,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319754017","type":"print"},{"value":"9783319754024","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-75402-4_49","type":"book-chapter","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:23:42Z","timestamp":1525253022000},"page":"395-401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Bisretinoid Photodegradation Is Likely Not a Good Thing"],"prefix":"10.1007","author":[{"given":"Keiko","family":"Ueda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet R.","family":"Sparrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"key":"49_CR1","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","volume":"119","author":"Age-Related Eye Disease Study Research G","year":"2001","unstructured":"Age-Related Eye Disease Study Research G (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 119:1417\u20131436","journal-title":"Arch Ophthalmol"},{"key":"49_CR2","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1002\/1521-3773(20020301)41:5<814::AID-ANIE814>3.0.CO;2-2","volume":"41","author":"S Ben-Shabat","year":"2002","unstructured":"Ben-Shabat S, Itagaki Y, Jockusch S et al (2002) Formation of a nona-oxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed 41:814\u2013817","journal-title":"Angew Chem Int Ed"},{"key":"49_CR3","doi-asserted-by":"publisher","first-page":"22276","DOI":"10.1074\/jbc.M111.329235","volume":"287","author":"NP Boyer","year":"2012","unstructured":"Boyer NP, Higbee D, Currin MB et al (2012) Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in the retinal pigment epithelium in the absence of light exposure: their origin is 11-cis retinal. J Biol Chem 287:22276\u201322286","journal-title":"J Biol Chem"},{"key":"49_CR4","first-page":"246","volume":"119","author":"KJ Cruickshanks","year":"2001","unstructured":"Cruickshanks KJ, Klein R, Klein BEK et al (2001) Sunlight and the 5-year incidence of early age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol 119:246\u2013250","journal-title":"Arch Ophthalmol"},{"key":"49_CR5","first-page":"11","volume":"5","author":"B Farboud","year":"1999","unstructured":"Farboud B, Aotaki-Keen A, Miyata T et al (1999) Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch\u2019s membrane of the aging eye. Mol Vis 5:11","journal-title":"Mol Vis"},{"key":"49_CR6","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1001\/archopht.126.10.1396","volume":"126","author":"AE Fletcher","year":"2008","unstructured":"Fletcher AE, Bentham GC, Agnew M et al (2008) Sunlight exposure, antioxidants, and age-related macular degeneration. Arch Ophthalmol 126:1396\u20131403","journal-title":"Arch Ophthalmol"},{"key":"49_CR7","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1167\/iovs.14-14136","volume":"55","author":"E Flynn","year":"2014","unstructured":"Flynn E, Ueda K, Auran E et al (2014) Fundus autofluorescence and photoreceptor cell rosettes in mouse models. Invest Ophthalmol Vis Sci 55:5643\u20135652","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR8","doi-asserted-by":"crossref","unstructured":"Fritsche LG, Igl W, Bailey JN et al (2016) A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet 48(2):134\u2013143","DOI":"10.1038\/ng.3448"},{"key":"49_CR9","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/j.1751-1097.1995.tb02343.x","volume":"61","author":"ER Gaillard","year":"1995","unstructured":"Gaillard ER, Atherton SJ, Eldred G et al (1995) Photophysical studies on human retinal lipofuscin. Photochem Photobiol 61:448\u2013453","journal-title":"Photochem Photobiol"},{"key":"49_CR10","first-page":"775","volume":"40","author":"JT Handa","year":"1999","unstructured":"Handa JT, Verzijl N, Matsunaga H et al (1999) Increase in advanced glycation end product pentosidine in Bruch\u2019s membrane with age. Invest Ophthalmol Vis Sci 40:775\u2013779","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR11","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/eye.2014.55","volume":"28","author":"EJ Huang","year":"2014","unstructured":"Huang EJ, Wu SH, Lai CH et al (2014) Prevalence and risk factors for age-related macular degeneration in the elderly Chinese population in south-western Taiwan: the Puzih eye study. Eye (Lond) 28:705\u2013714","journal-title":"Eye (Lond)"},{"key":"49_CR12","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.preteyeres.2011.11.001","volume":"31","author":"JJ Hunter","year":"2012","unstructured":"Hunter JJ, Morgan JI, Merigan WH et al (2012) The susceptibility of the retina to photochemical damage from visible light. Prog Retin Eye Res 31:28\u201342","journal-title":"Prog Retin Eye Res"},{"key":"49_CR13","doi-asserted-by":"publisher","first-page":"39732","DOI":"10.1074\/jbc.M504933200","volume":"280","author":"YP Jang","year":"2005","unstructured":"Jang YP, Matsuda H, Itagaki Y et al (2005) Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cells lipofuscin. J Biol Chem 280:39732\u201339739","journal-title":"J Biol Chem"},{"key":"49_CR14","doi-asserted-by":"publisher","first-page":"11668","DOI":"10.1073\/pnas.0403499101","volume":"101","author":"SR Kim","year":"2004","unstructured":"Kim SR, Fishkin N, Kong J et\u00a0al (2004) The Rpe65 Leu450Met variant is associated with reduced levels of the RPE lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A 101:11668\u201311672","journal-title":"Proc Natl Acad Sci U S A"},{"key":"49_CR15","doi-asserted-by":"publisher","first-page":"19273","DOI":"10.1073\/pnas.0708714104","volume":"104","author":"SR Kim","year":"2007","unstructured":"Kim SR, Jang YP, Jockusch S et al (2007) The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model. Proc Natl Acad Sci U S A 104:19273\u201319278","journal-title":"Proc Natl Acad Sci U S A"},{"key":"49_CR16","doi-asserted-by":"publisher","first-page":"5855","DOI":"10.1167\/iovs.14-14602","volume":"55","author":"BE Klein","year":"2014","unstructured":"Klein BE, Howard KP, Iyengar SK et al (2014) Sunlight exposure, pigmentation, and incident age-related macular degeneration. Invest Ophthalmol Vis Sci 55:5855\u20135861","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR17","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0014-4835(75)90080-9","volume":"21","author":"MM LaVail","year":"1975","unstructured":"LaVail MM, Battelle B-A (1975) Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. Exp Eye Res 21:167","journal-title":"Exp Eye Res"},{"key":"49_CR18","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1167\/iovs.07-1470","volume":"49","author":"RA Radu","year":"2008","unstructured":"Radu RA, Yuan Q, Hu J et\u00a0al (2008) Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following vitamin A supplementation. Invest Ophthalmol Vis Sci 49:3821\u20133829","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR19","doi-asserted-by":"publisher","first-page":"18593","DOI":"10.1074\/jbc.M110.191866","volume":"286","author":"RA Radu","year":"2011","unstructured":"Radu RA, Hu J, Yuan Q et al (2011) Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. J Biol Chem 286:18593\u201318601","journal-title":"J Biol Chem"},{"key":"49_CR20","doi-asserted-by":"publisher","first-page":"18825","DOI":"10.1074\/jbc.270.32.18825","volume":"270","author":"M Rozanowska","year":"1995","unstructured":"Rozanowska M, Jarvis-Evans J, Korytowski W et al (1995) Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species. J Biol Chem 270:18825\u201318830","journal-title":"J Biol Chem"},{"key":"49_CR21","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1001\/archopht.125.5.671","volume":"125","author":"JP SanGiovanni","year":"2007","unstructured":"SanGiovanni JP, Chew EY, Clemons TE et al (2007) The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS report no. 20. Arch Ophthalmol 125:671\u2013679","journal-title":"Arch Ophthalmol"},{"issue":"suppl","key":"49_CR22","doi-asserted-by":"publisher","first-page":"1448S","DOI":"10.1093\/ajcn\/62.6.1448S","volume":"62","author":"DM Snodderly","year":"1995","unstructured":"Snodderly DM (1995) Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr 62(suppl):1448S\u20131461S","journal-title":"Am J Clin Nutr"},{"key":"49_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2013.12.004","volume":"40","author":"L Sobrin","year":"2014","unstructured":"Sobrin L, Seddon JM (2014) Nature and nurture- genes and environment- predict onset and progression of macular degeneration. Prog Retin Eye Res 40:1\u201315","journal-title":"Prog Retin Eye Res"},{"key":"49_CR24","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.3390\/jcm3041302","volume":"3","author":"JR Sparrow","year":"2014","unstructured":"Sparrow JR, Duncker T (2014) Fundus autofluorescence and RPE lipofuscin in age-related macular degeneration. J Clin Med 3:1302\u20131321","journal-title":"J Clin Med"},{"key":"49_CR25","doi-asserted-by":"publisher","first-page":"18207","DOI":"10.1074\/jbc.M300457200","volume":"278","author":"JR Sparrow","year":"2003","unstructured":"Sparrow JR, Vollmer-Snarr HR, Zhou J et\u00a0al (2003) A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J Biol Chem 278:18207\u201318213","journal-title":"J Biol Chem"},{"key":"49_CR26","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1167\/iovs.10-5852","volume":"51","author":"JR Sparrow","year":"2010","unstructured":"Sparrow JR, Yoon K, Wu Y et al (2010) Interpretations of fundus autofluorescence from studies of the bisretinoids of retina. Invest Ophthalmol Vis Sci 51:4351\u20134357","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR27","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.preteyeres.2011.12.001","volume":"31","author":"JR Sparrow","year":"2012","unstructured":"Sparrow JR, Gregory-Roberts E, Yamamoto K et al (2012) The bisretinoids of retinal pigment epithelium. Prog Retin Eye Res 31:121\u2013135","journal-title":"Prog Retin Eye Res"},{"key":"49_CR28","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1167\/iovs.12-11490","volume":"54","author":"JR Sparrow","year":"2013","unstructured":"Sparrow JR, Blonska A, Flynn E et al (2013) Quantitative fundus autofluorescence in mice: correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness. Invest Ophthalmol Vis Sci 54:2812\u20132820","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR29","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1136\/bjophthalmol-2012-302281","volume":"97","author":"GY Sui","year":"2013","unstructured":"Sui GY, Liu GC, Liu GY et al (2013) Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. Br J Ophthalmol 97:389\u2013394","journal-title":"Br J Ophthalmol"},{"issue":"964\u2013972","key":"49_CR30","first-page":"e962","volume":"159","author":"MM Teussink","year":"2015","unstructured":"Teussink MM, Lee MD, Smith RT et al (2015) The effect of light deprivation in patients with Stargardt disease. Am J Ophthalmol 159(964\u2013972):e962","journal-title":"Am J Ophthalmol"},{"key":"49_CR31","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1001\/archopht.122.5.750","volume":"122","author":"SC Tomany","year":"2004","unstructured":"Tomany SC, Cruickshanks KJ, Klein R et al (2004) Sunlight and the 10-year incidence of age-related maculopathy. The Beaver Dam Eye Study. Arch Ophthalmol 122:750\u2013757","journal-title":"Arch Ophthalmol"},{"key":"49_CR32","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.1073\/pnas.1524774113","volume":"113","author":"K Ueda","year":"2016","unstructured":"Ueda K, Zhao J, Kim HJ et al (2016) Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration. Proc Natl Acad Sci 113:6904\u20136909","journal-title":"Proc Natl Acad Sci"},{"key":"49_CR33","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/0042-6989(91)90057-C","volume":"31","author":"TJTP Berg van den","year":"1991","unstructured":"van den Berg TJTP, IJspeert JK, deWaard PWT (1991) Dependence of intraocular straylight on pigmentation and light transmission through the ocular wall. Vis Res 31:1361\u20131367","journal-title":"Vis Res"},{"key":"49_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0092-8674(00)80602-9","volume":"98","author":"J Weng","year":"1999","unstructured":"Weng J, Mata NL, Azarian SM et al (1999) Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell 98:13\u201323","journal-title":"Cell"},{"key":"49_CR35","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/978-1-4419-1399-9_61","volume":"664","author":"L Wu","year":"2010","unstructured":"Wu L, Nagasaki T, Sparrow JR (2010a) Photoreceptor cell degeneration in Abcr\n\u2212\/\u2212 mice. Adv Exp Med Biol 664:533\u2013539","journal-title":"Adv Exp Med Biol"},{"key":"49_CR36","doi-asserted-by":"publisher","first-page":"7275","DOI":"10.1073\/pnas.0913112107","volume":"107","author":"Y Wu","year":"2010","unstructured":"Wu Y, Yanase E, Feng X et al (2010b) Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc Natl Acad Sci 107:7275\u20137280","journal-title":"Proc Natl Acad Sci"},{"key":"49_CR37","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1167\/iovs.14-13867","volume":"55","author":"L Wu","year":"2014","unstructured":"Wu L, Ueda K, Nagasaki T et al (2014) Light damage in Abca4 and Rpe65rd12 mice. Invest Ophthalmol Vis Sci 55:1910\u20131918","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR38","doi-asserted-by":"publisher","first-page":"9084","DOI":"10.1167\/iovs.11-8632","volume":"52","author":"K Yamamoto","year":"2011","unstructured":"Yamamoto K, Yoon KD, Ueda K et al (2011) A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine. Invest Ophthalmol Vis Sci 52:9084\u20139090","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR39","doi-asserted-by":"publisher","first-page":"3536","DOI":"10.1167\/iovs.12-9535","volume":"53","author":"K Yamamoto","year":"2012","unstructured":"Yamamoto K, Zhou J, Hunter JJ et al (2012) Toward an understanding of bisretinoid autofluorescence bleaching and recovery. Invest Ophthalmol Vis Sci 53:3536\u20133544","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49_CR40","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1089\/rej.2006.9.256","volume":"9","author":"J Zhou","year":"2006","unstructured":"Zhou J, Gao X, Cai B et al (2006) Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment. Rejuvenation Res 9:256\u2013263","journal-title":"Rejuvenation Res"},{"key":"49_CR41","doi-asserted-by":"publisher","first-page":"27215","DOI":"10.1074\/jbc.M115.680363","volume":"290","author":"J Zhou","year":"2015","unstructured":"Zhou J, Ueda K, Zhao J et\u00a0al (2015) Correlations between photodegradation of bisretinoid constituents of retina and dicarbonyl-adduct deposition. J Biol Chem 290:27215\u201327227","journal-title":"J Biol Chem"}],"container-title":["Advances in Experimental Medicine and Biology","Retinal Degenerative Diseases"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-75402-4_49","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:30:19Z","timestamp":1525253419000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-75402-4_49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319754017","9783319754024"],"references-count":41,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-75402-4_49","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}