{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:56:02Z","timestamp":1780541762545,"version":"3.54.1"},"publisher-location":"Cham","reference-count":32,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319754017","type":"print"},{"value":"9783319754024","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-75402-4_9","type":"book-chapter","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:23:42Z","timestamp":1525253022000},"page":"69-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mini-Review: Cell Type-Specific Optogenetic Vision Restoration Approaches"],"prefix":"10.1007","author":[{"given":"Antoine","family":"Chaffiol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Duebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neuron.2006.02.026","volume":"50","author":"A Bi","year":"2006","unstructured":"Bi A, Cui J, Ma YP et al (2006) Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50:23\u201333","journal-title":"Neuron"},{"key":"9_CR2","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1038\/nn1525","volume":"8","author":"ES Boyden","year":"2005","unstructured":"Boyden ES, Zhang F, Bamberg E et al (2005) Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci 8:1263\u20131268","journal-title":"Nat Neurosci"},{"key":"9_CR3","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1126\/science.1190897","volume":"329","author":"V Busskamp","year":"2010","unstructured":"Busskamp V, Duebel J, Balya D et al (2010) Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 329:413\u2013417","journal-title":"Science"},{"key":"9_CR4","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/mt.2011.103","volume":"19","author":"N Caporale","year":"2011","unstructured":"Caporale N, Kolstad KD, Lee T et al (2011) LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther 19:1212\u20131219. article","journal-title":"Mol Ther"},{"key":"9_CR5","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1016\/j.cub.2015.07.029","volume":"25","author":"J Cehajic-Kapetanovic","year":"2015","unstructured":"Cehajic-Kapetanovic J, Eleftheriou C, Allen AEE et al (2015) Restoration of vision with ectopic expression of human rod opsin. Curr Biol 25:2111\u20132122. article","journal-title":"Curr Biol"},{"key":"9_CR6","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.15252\/emmm.201404077","volume":"6","author":"T Cronin","year":"2014","unstructured":"Cronin T, Vandenberghe LHH, Hantz P et al (2014) Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter. EMBO Mol Med 6:1175\u20131190. article","journal-title":"EMBO Mol Med"},{"key":"9_CR7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005708","volume":"5","author":"D Dalkara","year":"2013","unstructured":"Dalkara D, Byrne LC, Klimczak RR et al (2013) In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Sci Transl Med 5:189ra76","journal-title":"Sci Transl Med"},{"key":"9_CR8","doi-asserted-by":"publisher","first-page":"10380","DOI":"10.1523\/JNEUROSCI.3863-06.2006","volume":"26","author":"K Deisseroth","year":"2006","unstructured":"Deisseroth K, Feng G, Majewska AK et al (2006) Next-generation optical technologies for illuminating genetically targeted brain circuits. J Neurosci 26:10380\u201310386","journal-title":"J Neurosci"},{"key":"9_CR9","doi-asserted-by":"publisher","first-page":"E5574","DOI":"10.1073\/pnas.1414162111","volume":"111","author":"BMM Gaub","year":"2014","unstructured":"Gaub BMM, Berry MHH, Holt AEE et al (2014) Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proc Natl Acad Sci U S A 111:E5574\u2013E5583. article","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"9_CR10","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1038\/mt.2015.121","volume":"23","author":"BM Gaub","year":"2015","unstructured":"Gaub BM, Berry MH, Holt AE et al (2015) Optogenetic vision restoration using rhodopsin for enhanced sensitivity. Mol Ther 23(10):1562\u20131571. article","journal-title":"Mol Ther"},{"key":"9_CR11","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.neuron.2011.01.024","volume":"69","author":"KP Greenberg","year":"2011","unstructured":"Greenberg KP, Pham A, Werblin FS (2011) Differential targeting of optical neuromodulators to ganglion cell soma and dendrites allows dynamic control of center-surround antagonism. Neuron 69:713\u2013720. article","journal-title":"Neuron"},{"key":"9_CR12","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/nmeth.3111","volume":"11","author":"M H\u00e4usser","year":"2014","unstructured":"H\u00e4usser M (2014) Optogenetics: the age of light. Nat Methods 11:1012\u20131014","journal-title":"Nat Methods"},{"issue":"1","key":"9_CR13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.conb.2006.12.002","volume":"16","author":"S Herlitze","year":"2007","unstructured":"Herlitze S, Landmesser LT (2007) New optical tools for controlling neuronal activity. Curr Opin Neurobiol 16(1):87\u201394","journal-title":"Curr Opin Neurobiol"},{"key":"9_CR14","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.ophtha.2011.09.028","volume":"119","author":"MS Humayun","year":"2012","unstructured":"Humayun MS, Dorn JD, da Cruz L et al (2012) Interim results from the international trial of second Sight\u2019s visual prosthesis. Ophthalmology 119:779\u2013788","journal-title":"Ophthalmology"},{"key":"9_CR15","first-page":"1680","volume":"15","author":"E Ivanova","year":"2009","unstructured":"Ivanova E, Pan Z-H (2009) Evaluation of the adeno-associated virus mediated long-term expression of channelrhodopsin-2 in the mouse retina. Mol Vis 15:1680\u20131689","journal-title":"Mol Vis"},{"key":"9_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/cge.12165","volume":"84","author":"SG Jacobson","year":"2013","unstructured":"Jacobson SG, Sumaroka A, Luo X et al (2013) Retinal optogenetic therapies: clinical criteria for candidacy. Clin Genet 84:175\u2013182. article","journal-title":"Clin Genet"},{"key":"9_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.exer.2016.03.018","volume":"150","author":"BW Jones","year":"2016","unstructured":"Jones BW, Pfeiffer RL, Ferrell WD et al (2016) Retinal remodeling in human retinitis pigmentosa. Exp Eye Res 150:149\u2013165","journal-title":"Exp Eye Res"},{"key":"9_CR18","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nn.2117","volume":"11","author":"PS Lagali","year":"2008","unstructured":"Lagali PS, Balya D, Awatramani GB et al (2008) Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci 11:667\u2013675. article","journal-title":"Nat Neurosci"},{"key":"9_CR19","doi-asserted-by":"publisher","first-page":"16009","DOI":"10.1073\/pnas.0806114105","volume":"105","author":"B Lin","year":"2008","unstructured":"Lin B, Koizumi A, Tanaka N et al (2008) Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci U S A 105:16009\u201316014. article","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9_CR20","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.exer.2008.11.022","volume":"88","author":"B Lin","year":"2009","unstructured":"Lin B, Masland RH, Strettoi E (2009) Remodeling of cone photoreceptor cells after rod degeneration in rd mice. Exp Eye Res 88:589\u2013599","journal-title":"Exp Eye Res"},{"key":"9_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/mt.2014.154","volume":"23","author":"E Mac\u00e9","year":"2015","unstructured":"Mac\u00e9 E, Caplette R, Marre O et al (2015) Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV restores ON and OFF visual responses in blind mice. Mol Ther 23:7\u201316. article","journal-title":"Mol Ther"},{"key":"9_CR22","doi-asserted-by":"publisher","first-page":"13940","DOI":"10.1073\/pnas.1936192100","volume":"100","author":"G Nagel","year":"2003","unstructured":"Nagel G, Szellas T, Huhn W et al (2003) Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc Natl Acad Sci U S A 100:13940\u201313945. article","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/newbio233149a0","volume":"233","author":"D Oesterhelt","year":"1971","unstructured":"Oesterhelt D, Stoeckenius W (1971) Rhodopsin-like protein from the purple membrane of Halobacterium halobium. Nat New Biol 233:149\u2013152","journal-title":"Nat New Biol"},{"key":"9_CR24","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1146\/annurev-neuro-062012-170304","volume":"36","author":"J-AA Sahel","year":"2013","unstructured":"Sahel J-AA, Roska B (2013) Gene therapy for blindness. Annu Rev Neurosci 36:467\u2013488","journal-title":"Annu Rev Neurosci"},{"issue":"11","key":"9_CR25","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.15252\/emmm.201505699","volume":"8","author":"Abhishek Sengupta","year":"2016","unstructured":"Sengupta A, Chaffiol A, Mac\u00e9 E et al (2016) Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina. EMBO Mol Med 8:1248\u20131264","journal-title":"EMBO Molecular Medicine"},{"key":"9_CR26","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.tibtech.2013.07.001","volume":"31","author":"RK Shepherd","year":"2013","unstructured":"Shepherd RK, Shivdasani MN, Nayagam DAX et al (2013) Visual prostheses for the blind. Trends Biotechnol 31:562\u2013571. article","journal-title":"Trends Biotechnol"},{"key":"9_CR27","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/oxfordjournals.jbchem.a134852","volume":"96","author":"Y Sugiyama","year":"1984","unstructured":"Sugiyama Y, Mukohata Y (1984) Isolation and characterization of halorhodopsin from Halobacterium halobium. J Biochem 96:413\u2013420","journal-title":"J Biochem"},{"key":"9_CR28","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1167\/iovs.06-1501","volume":"48","author":"H Tomita","year":"2007","unstructured":"Tomita H, Sugano E, Yawo H et al (2007) Restoration of visual response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene transfer. Invest Ophthalmol Vis Sci 48:3821\u20133826. article","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9_CR29","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.exer.2009.12.006","volume":"90","author":"H Tomita","year":"2010","unstructured":"Tomita H, Sugano E, Isago H et al (2010) Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats. Exp Eye Res 90:429\u2013436","journal-title":"Exp Eye Res"},{"key":"9_CR30","doi-asserted-by":"publisher","first-page":"e66332","DOI":"10.1371\/journal.pone.0066332","volume":"8","author":"C Wu","year":"2013","unstructured":"Wu C, Ivanova E, Zhang Y et al (2013) rAAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells in vivo. PLoS One 8:e66332. article","journal-title":"PLoS One"},{"key":"9_CR31","doi-asserted-by":"publisher","first-page":"e1002143","DOI":"10.1371\/journal.pbio.1002143","volume":"13","author":"M Wyk van","year":"2015","unstructured":"van Wyk M, Pielecka-Fortuna J, L\u00f6wel S et al (2015) Restoring the ON switch in blind retinas: opto-mGluR6, a next-generation, cell-tailored optogenetic tool. PLoS Biol 13:e1002143. article","journal-title":"PLoS Biol"},{"key":"9_CR32","doi-asserted-by":"publisher","first-page":"9186","DOI":"10.1523\/JNEUROSCI.0184-09.2009","volume":"29","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Ivanova E, Bi A et al (2009) Ectopic expression of multiple microbial rhodopsins restores ON and OFF light responses in retinas with photoreceptor degeneration. J Neurosci 29:9186\u20139196","journal-title":"J Neurosci"}],"container-title":["Advances in Experimental Medicine and Biology","Retinal Degenerative Diseases"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-75402-4_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:24:33Z","timestamp":1525253073000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-75402-4_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319754017","9783319754024"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-75402-4_9","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}