{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:11:52Z","timestamp":1773292312336,"version":"3.50.1"},"publisher-location":"Cham","reference-count":124,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319767345","type":"print"},{"value":"9783319767352","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-76735-2_15","type":"book-chapter","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T15:38:00Z","timestamp":1525707480000},"page":"331-350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Models of Disease"],"prefix":"10.1007","author":[{"given":"Gema","family":"Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"L\u00f3pez-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Antich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Chocarro-Wrona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Marchal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"issue":"1","key":"15_CR1","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1186\/ar4436","volume":"16","author":"S Adaes","year":"2014","unstructured":"Adaes S et al (2014) Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis. Arthritis Res Ther 16(1):R10","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"15_CR2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.joca.2008.11.008","volume":"17","author":"BJ Ahern","year":"2009","unstructured":"Ahern BJ et al (2009) Preclinical animal models in single site cartilage defect testing: a systematic review. Osteoarthr Cartil 17(6):705\u2013713","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"15_CR3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00018-002-8400-3","volume":"59","author":"T Aigner","year":"2002","unstructured":"Aigner T, McKenna L (2002) Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci 59(1):5\u201318","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"15_CR4","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1002\/art.24783","volume":"60","author":"KD Allen","year":"2009","unstructured":"Allen KD et al (2009) Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum 60(9):2684\u20132693","journal-title":"Arthritis Rheum"},{"issue":"3","key":"15_CR5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.11005\/jbm.2016.23.3.121","volume":"23","author":"H Asahara","year":"2016","unstructured":"Asahara H (2016) Current status and strategy of microRNA research for cartilage development and osteoarthritis pathogenesis. J Bone Metab 23(3):121\u2013127","journal-title":"J Bone Metab"},{"issue":"7","key":"15_CR6","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/art.30364","volume":"63","author":"M Beekhuizen","year":"2011","unstructured":"Beekhuizen M et al (2011) Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture. Arthritis Rheum 63(7):1918\u20131927","journal-title":"Arthritis Rheum"},{"key":"15_CR7","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.addr.2014.08.010","volume":"84","author":"M Bhattacharjee","year":"2015","unstructured":"Bhattacharjee M et al (2015) Tissue engineering strategies to study cartilage development, degeneration and regeneration. Adv Drug Deliv Rev 84:107\u2013122. Available at: https:\/\/doi.org\/10.1016\/j.addr.2014.08.010","journal-title":"Adv Drug Deliv Rev"},{"key":"15_CR8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2741\/e361","volume":"4","author":"Q Bian","year":"2012","unstructured":"Bian Q et al (2012) Osteoarthritis: genetic factors, animal models, mechanisms, and therapies. Front Biosci (Elite Ed) 4:74\u2013100","journal-title":"Front Biosci (Elite Ed)"},{"issue":"9783","key":"15_CR9","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","volume":"377","author":"JWJ Bijlsma","year":"2011","unstructured":"Bijlsma JWJ, Berenbaum F, Lafeber FPJG (2011) Osteoarthritis: an update with relevance for clinical practice. Lancet 377(9783):2115\u20132126","journal-title":"Lancet"},{"issue":"4","key":"15_CR10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.matbio.2007.11.007","volume":"27","author":"K Blumbach","year":"2008","unstructured":"Blumbach K et al (2008) Ablation of collagen IX and COMP disrupts epiphyseal cartilage architecture. Matrix Biol: J Int So Matrix Biol 27(4):306\u2013318","journal-title":"Matrix Biol: J Int So Matrix Biol"},{"issue":"11","key":"15_CR11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1063-4584(03)00163-8","volume":"11","author":"S.E Bove","year":"2003","unstructured":"Bove SE et al (2003) Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthr Cartil 11(11):821\u2013830. Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14609535 . Accessed 26 May 2017","journal-title":"Osteoarthritis and Cartilage"},{"issue":"3","key":"15_CR12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/jor.1100120305","volume":"12","author":"CS Carlson","year":"1994","unstructured":"Carlson CS et al (1994) Osteoarthritis in cynomolgus macaques: a primate model of naturally occurring disease. J Orthop Res: Off Publ Orthop Res Soc 12(3):331\u2013339","journal-title":"J Orthop Res: Off Publ Orthop Res Soc"},{"issue":"7","key":"15_CR13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0925-4773(03)00067-4","volume":"120","author":"CM Coleman","year":"2003","unstructured":"Coleman CM, Tuan RS (2003) Functional role of growth\/differentiation factor 5 in chondrogenesis of limb mesenchymal cells. Mech Dev 120(7):823\u2013836","journal-title":"Mech Dev"},{"issue":"6","key":"15_CR14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.matbio.2006.03.005","volume":"25","author":"JNA Croos De","year":"2006","unstructured":"De Croos JNA et al (2006) Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation. Matrix Biol 25(6):323\u2013331","journal-title":"Matrix Biol"},{"key":"15_CR15","unstructured":"FDA (1999) Guidance for industry: clinical development programs for drugs, devices, and biological products intended for the treatment of osteoarthritis (OA). www.FDA.gov (July)"},{"issue":"1","key":"15_CR16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0003-9861(02)00658-6","volume":"410","author":"A Fehrenbacher","year":"2003","unstructured":"Fehrenbacher A et al (2003) Rapid regulation of collagen but not metalloproteinase 1, 3, 13, 14 and tissue inhibitor of metalloproteinase 1, 2, 3 expression in response to mechanical loading of cartilage explants in vitro. Arch Biochem Biophys 410(1):39\u201347","journal-title":"Arch Biochem Biophys"},{"issue":"12","key":"15_CR17","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1002\/art.11341","volume":"48","author":"F Finger","year":"2003","unstructured":"Finger F et al (2003) Molecular phenotyping of human chondrocyte cell lines T\/C-28a2, T\/C-28a4, and C-28\/I2. Arthritis Rheum 48(12):3395\u20133403","journal-title":"Arthritis Rheum"},{"issue":"10","key":"15_CR18","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.joca.2008.03.008","volume":"16","author":"DD Frisbie","year":"2008","unstructured":"Frisbie DD et al (2008) Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses. Osteoarthr Cartil 16(10):1196\u20131204","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"15_CR19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1055\/s-0038-1632990","volume":"19","author":"DD Frisbie","year":"2006","unstructured":"Frisbie DD, Cross MW, McIlwraith CW (2006) A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee. Vet Comp Orthop Traumatol: VCOT 19(3):142\u2013146","journal-title":"Vet Comp Orthop Traumatol: VCOT"},{"key":"15_CR20","doi-asserted-by":"crossref","first-page":"S273","DOI":"10.1097\/00003086-200010001-00037","volume":"379 Suppl","author":"DD Frisbie","year":"2000","unstructured":"Frisbie DD, McIlwraith CW (2000) Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis. Clin Orthop Relat Res 379 Suppl:S273\u2013S287","journal-title":"Clin Orthop Relat Res"},{"issue":"8","key":"15_CR21","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jfms.2010.03.007","volume":"12","author":"N Gabriel","year":"2010","unstructured":"Gabriel N et al (2010) Development of an in vitro model of feline cartilage degradation. J Feline Med Surg 12(8):614\u2013620. Available at: https:\/\/doi.org\/10.1016\/j.jfms.2010.03.007","journal-title":"J Feline Med Surg"},{"issue":"04","key":"15_CR22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1055\/s-0031-1297361","volume":"24","author":"Bridget Garner","year":"2011","unstructured":"Garner BC et al (2011) Using animal models in osteoarthritis biomarker research. J Knee Surg 24(4):251\u2013264. Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22303754 . Accessed 26 May 2017","journal-title":"Journal of Knee Surgery"},{"issue":"Suppl 3","key":"15_CR23","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","volume":"18","author":"N Gerwin","year":"2010","unstructured":"Gerwin N et al (2010) The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat. Osteoarthr Cartil 18(Suppl 3):S24\u2013S34","journal-title":"Osteoarthr Cartil"},{"issue":"42","key":"15_CR24","doi-asserted-by":"crossref","first-page":"30960","DOI":"10.1074\/jbc.M705730200","volume":"282","author":"J Gouttenoire","year":"2007","unstructured":"Gouttenoire J et\u00a0al (2007) Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. J Biol Chem 282(42):30960\u201330973","journal-title":"J Biol Chem"},{"key":"15_CR25","doi-asserted-by":"crossref","first-page":"764621","DOI":"10.1155\/2012\/764621","volume":"2012","author":"MH Gregory","year":"2012","unstructured":"Gregory MH et al (2012) A review of translational animal models for knee osteoarthritis. Arthritis 2012:764621","journal-title":"Arthritis"},{"issue":"8","key":"15_CR26","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1002\/art.34435","volume":"64","author":"G Groma","year":"2012","unstructured":"Groma G et al (2012) Abnormal bone quality in cartilage oligomeric matrix protein and matrilin 3 double-deficient mice caused by increased tissue inhibitor of metalloproteinases 3 deposition and delayed aggrecan degradation. Arthritis Rheum 64(8):2644\u20132654","journal-title":"Arthritis Rheum"},{"issue":"8","key":"15_CR27","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1007\/s00167-014-3009-2","volume":"23","author":"K Gruchenberg","year":"2015","unstructured":"Gruchenberg K et al (2015) In vivo performance of a novel silk fibroin scaffold for partial meniscal replacement in a sheep model. Knee Surg Sports Traumatol Arthrosc: Off J ESSKA 23(8):2218\u20132229","journal-title":"Knee Surg Sports Traumatol Arthrosc: Off J ESSKA"},{"issue":"4","key":"15_CR28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3390\/jdb3040158","volume":"3","author":"A Hafez","year":"2015","unstructured":"Hafez A et al (2015) Col11a1 regulates bone microarchitecture during embryonic development. J Dev Biol 3(4):158\u2013176","journal-title":"J Dev Biol"},{"key":"15_CR29","doi-asserted-by":"crossref","first-page":"40489","DOI":"10.1038\/srep40489","volume":"7","author":"A He","year":"2017","unstructured":"He A et al (2017) Repair of osteochondral defects with in vitro engineered cartilage based on autologous bone marrow stromal cells in a swine model. Sci Rep 7:40489","journal-title":"Sci Rep"},{"key":"15_CR30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.matbio.2014.04.004","volume":"36","author":"TM Hering","year":"2014","unstructured":"Hering TM et al (2014) Changes in type II procollagen isoform expression during chondrogenesis by disruption of an alternative 5\u2032 splice site within Col2a1 exon 2. Matrix Biol: J Int Soc Matrix Biol 36:51\u201363","journal-title":"Matrix Biol: J Int Soc Matrix Biol"},{"issue":"1","key":"15_CR31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13075-017-1245-9","volume":"19","author":"J Hillen","year":"2017","unstructured":"Hillen J et\u00a0al (2017) Structural cartilage damage attracts circulating rheumatoid arthritis synovial fibroblasts into affected joints. Arthritis Res Ther 19(1):40","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"15_CR32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/026119291003800208","volume":"38","author":"CR Hooijmans","year":"2010","unstructured":"Hooijmans CR, Leenaars M, Ritskes-Hoitinga M (2010) A gold standard publication checklist to improve the quality of animal studies, to fully integrate the three Rs, and to make systematic reviews more feasible. Altern Lab Anim: ATLA 38(2):167\u2013182","journal-title":"Altern Lab Anim: ATLA"},{"key":"15_CR33","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.matbio.2014.08.012","volume":"39","author":"MF Hsueh","year":"2014","unstructured":"Hsueh MF, \u00d6nnerfjord P, Kraus VB (2014) Biomarkers and proteomic analysis of osteoarthritis. Matrix Biol 39:56\u201366. Available at: https:\/\/doi.org\/10.1016\/j.matbio.2014.08.012","journal-title":"Matrix Biol"},{"issue":"7542","key":"15_CR34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/bmj.332.7542.639","volume":"332","author":"DJ Hunter","year":"2006","unstructured":"Hunter DJ, Felson DT (2006) Osteoarthritis. BMJ (Clinical research ed) 332(7542):639\u2013642","journal-title":"BMJ (Clinical research ed)"},{"issue":"7","key":"15_CR35","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrrheum.2014.44","volume":"10","author":"DJ Hunter","year":"2014","unstructured":"Hunter DJ, Schofield D, Callander E (2014) The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol 10(7):437\u2013441. Available at: https:\/\/doi.org\/10.1038\/nrrheum.2014.44","journal-title":"Nat Rev Rheumatol"},{"issue":"9","key":"15_CR36","first-page":"1666","volume":"25","author":"T Ikeda","year":"1998","unstructured":"Ikeda T et al (1998) Adenovirus mediated gene delivery to the joints of Guinea pigs. J Rheumatol 25(9):1666\u20131673","journal-title":"J Rheumatol"},{"issue":"52","key":"15_CR37","doi-asserted-by":"crossref","first-page":"37420","DOI":"10.1074\/jbc.M703184200","volume":"282","author":"MZ Ilic","year":"2007","unstructured":"Ilic MZ et al (2007) Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice. J Biol Chem 282(52):37420\u201337428","journal-title":"J Biol Chem"},{"issue":"5","key":"15_CR38","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.joca.2007.09.004","volume":"16","author":"K Jaeger","year":"2008","unstructured":"Jaeger K et al (2008) The genetics of osteoarthritis in STR\/ort mice. Osteoarthr Cartil 16(5):607\u2013614","journal-title":"Osteoarthr Cartil"},{"key":"15_CR39","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez G et al (2015) Activin a\/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes. Sci Rep 5(1):16400. Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26563344 . Accessed 26 May 2017","DOI":"10.1038\/srep16400"},{"issue":"6","key":"15_CR40","first-page":"598","volume":"47","author":"PA Jimenez","year":"1997","unstructured":"Jimenez PA et al (1997) Spontaneous osteoarthritis in Dunkin Hartley Guinea pigs: histologic, radiologic, and biochemical changes. Lab Anim Sci 47(6):598\u2013601","journal-title":"Lab Anim Sci"},{"key":"15_CR41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tvjl.2015.07.011","volume":"209","author":"CI Johnson","year":"2016","unstructured":"Johnson CI, Argyle DJ, Clements DN (2016) In vitro models for the study of osteoarthritis. Vet J 209:40\u201349","journal-title":"Vet J"},{"issue":"6","key":"15_CR42","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s13075-014-0488-y","volume":"16","author":"Y Kawanishi","year":"2014","unstructured":"Kawanishi Y et al (2014) Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model. Arthritis Res Ther 16(6):488","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"15_CR43","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.joca.2008.04.015","volume":"16","author":"CE Kawcak","year":"2008","unstructured":"Kawcak CE et al (2008) Effects of exercise vs experimental osteoarthritis on imaging outcomes. Osteoarthr Cartil 16(12):1519\u20131525","journal-title":"Osteoarthr Cartil"},{"key":"15_CR44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.22203\/eCM.v025a13","volume":"25","author":"G Kerckhofs","year":"2013","unstructured":"Kerckhofs G et al (2013) Contrast-enhanced nanofocus computed tomography images the cartilage subtissue architecture in three dimensions. Eur Cell Mater 25:179\u2013189. Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23389752 . Accessed 26 May 2017","journal-title":"European Cells and Materials"},{"key":"15_CR45","doi-asserted-by":"crossref","first-page":"18011","DOI":"10.1038\/srep18011","volume":"5","author":"Y-I Kim","year":"2015","unstructured":"Kim Y-I et al (2015) Cartilage development requires the function of estrogen-related receptor alpha that directly regulates sox9 expression in zebrafish. Sci Rep 5:18011","journal-title":"Sci Rep"},{"issue":"2","key":"15_CR46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10059-013-0117-7","volume":"36","author":"Y-I Kim","year":"2013","unstructured":"Kim Y-I et al (2013) Establishment of a bone-specific col10a1:GFP transgenic zebrafish. Mol Cells 36(2):145\u2013150","journal-title":"Mol Cells"},{"issue":"11","key":"15_CR47","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1517\/14712598.7.11.1621","volume":"7","author":"TG Koch","year":"2007","unstructured":"Koch TG, Betts DH (2007) Stem cell therapy for joint problems using the horse as a clinically relevant animal model. Expert Opin Biol Ther 7(11):1621\u20131626","journal-title":"Expert Opin Biol Ther"},{"issue":"6","key":"15_CR48","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1089\/ten.tea.2007.0193","volume":"14","author":"E Kon","year":"2008","unstructured":"Kon E et al (2008) Tissue engineering for total meniscal substitution: animal study in sheep model. Tissue Eng A 14(6):1067\u20131080","journal-title":"Tissue Eng A"},{"issue":"1","key":"15_CR49","first-page":"19","volume":"71","author":"PM Kraan van der","year":"1990","unstructured":"van der Kraan PM et al (1990) Degenerative knee joint lesions in mice after a single intra-articular collagenase injection. A new model of osteoarthritis. J Exp Pathol (Oxford) 71(1):19\u201331","journal-title":"J Exp Pathol (Oxford)"},{"issue":"2","key":"15_CR50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.joca.2012.12.012","volume":"21","author":"PM Kraan van der","year":"2013","unstructured":"van der Kraan PM (2013) Relevance of zebrafish as an OA research model. Osteoarthr Cartil 21(2):261\u2013262","journal-title":"Osteoarthr Cartil"},{"key":"15_CR51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13018-016-0346-5","volume":"11","author":"EL Kuyinu","year":"2016","unstructured":"Kuyinu EL et al (2016) Animal models of osteoarthritis: classification, update, and measurement of outcomes. J Orthop Surg Res 11:19","journal-title":"J Orthop Surg Res"},{"issue":"4","key":"15_CR52","first-page":"346","volume":"61","author":"S Kyostio-Moore","year":"2011","unstructured":"Kyostio-Moore S et al (2011) STR\/ort mice, a model for spontaneous osteoarthritis, exhibit elevated levels of both local and systemic inflammatory markers. Comp Med 61(4):346\u2013355","journal-title":"Comp Med"},{"issue":"3","key":"15_CR53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00590-013-1205-2","volume":"24","author":"K Lampropoulou-Adamidou","year":"2014","unstructured":"Lampropoulou-Adamidou K et al (2014) Useful animal models for the research of osteoarthritis. Eur J Orthop Surg Traumatol: Orthop Traumatol 24(3):263\u2013271","journal-title":"Eur J Orthop Surg Traumatol: Orthop Traumatol"},{"issue":"1","key":"15_CR54","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/art.23176","volume":"58","author":"RC Lawrence","year":"2008","unstructured":"Lawrence RC et al (2008) Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part II. Arthritis Rheum 58(1):26\u201335. Available at: https:\/\/doi.org\/10.1002\/art.23176","journal-title":"Arthritis Rheum"},{"issue":"2","key":"15_CR55","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0722.2010.00710.x","volume":"118","author":"YY Lin","year":"2010","unstructured":"Lin YY et al (2010) Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system. Eur J Oral Sci 118(2):151\u2013158","journal-title":"Eur J Oral Sci"},{"issue":"4","key":"15_CR56","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.joca.2012.01.017","volume":"20","author":"CB Little","year":"2012","unstructured":"Little CB, Zaki S (2012) What constitutes an \u201canimal model of osteoarthritis\u201d--the need for consensus? Osteoarthr Cartil 20(4):261\u2013267","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"15_CR57","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0736-0266(03)00002-0","volume":"21","author":"W Liu","year":"2003","unstructured":"Liu W et al (2003) Spontaneous and experimental osteoarthritis in dog: similarities and differences in proteoglycan levels. J Orthop Res: Off Publ Orthop Res Soc 21(4):730\u2013737","journal-title":"J Orthop Res: Off Publ Orthop Res Soc"},{"issue":"1","key":"15_CR58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.yrtph.2012.03.010","volume":"63","author":"JC Madden","year":"2012","unstructured":"Madden JC et al (2012) Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy. Regul Toxicol Pharmacol 63(1):140\u2013154. Available at: http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0273230012000578","journal-title":"Regul Toxicol Pharmacol"},{"issue":"8 SUPPL","key":"15_CR59","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00198-012-2161-0","volume":"23","author":"M Mahjoub","year":"2012","unstructured":"Mahjoub M, Berenbaum F, Houard X (2012) Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis. Osteoporos Int 23(8 SUPPL):841\u2013846","journal-title":"Osteoporos Int"},{"issue":"10","key":"15_CR60","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.joca.2012.06.005","volume":"20","author":"J Malda","year":"2012","unstructured":"Malda J et\u00a0al (2012) Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles. Osteoarthr Cartil 20(10):1147\u20131151","journal-title":"Osteoarthr Cartil"},{"key":"15_CR61","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13075-015-0747-6","volume":"17","author":"A-M Malfait","year":"2015","unstructured":"Malfait A-M, Little CB (2015) On the predictive utility of animal models of osteoarthritis. Arthritis Res Ther 17:225","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"15_CR62","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bone.2011.10.008","volume":"51","author":"J Martel-Pelletier","year":"2012","unstructured":"Martel-Pelletier J, Wildi LM, Pelletier J-P (2012) Future therapeutics for osteoarthritis. Bone 51(2):297\u2013311","journal-title":"Bone"},{"issue":"3","key":"15_CR63","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/0363546509352448","volume":"38","author":"S Martinez-Diaz","year":"2010","unstructured":"Martinez-Diaz S et al (2010) In vivo evaluation of 3-dimensional polycaprolactone scaffolds for cartilage repair in rabbits. Am J Sports Med 38(3):509\u2013519","journal-title":"Am J Sports Med"},{"issue":"5","key":"15_CR64","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/0300985815588611","volume":"52","author":"AM McCoy","year":"2015","unstructured":"McCoy AM (2015) Animal models of osteoarthritis: comparisons and key considerations. Vet Pathol 52(5):803\u2013818","journal-title":"Vet Pathol"},{"issue":"11","key":"15_CR65","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1302\/2046-3758.111.2000132","volume":"1","author":"CW McIlwraith","year":"2012","unstructured":"McIlwraith CW, Frisbie DD, Kawcak CE (2012) The horse as a model of naturally occurring osteoarthritis. Bone Joint Res 1(11):297\u2013309","journal-title":"Bone Joint Res"},{"issue":"11","key":"15_CR66","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1002\/jor.20233","volume":"24","author":"MA Mello","year":"2006","unstructured":"Mello MA, Tuan RS (2006) Effects of TGF-beta1 and triiodothyronine on cartilage maturation: in vitro analysis using long-term high-density micromass cultures of chick embryonic limb mesenchymal cells. J Orthop Res: Off Publ Orthop Res Soc 24(11):2095\u20132105","journal-title":"J Orthop Res: Off Publ Orthop Res Soc"},{"issue":"7","key":"15_CR67","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.joca.2017.02.793","volume":"25","author":"AGH Mierzwa","year":"2017","unstructured":"Mierzwa AGH et al (2017) Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats. Osteoarthr Cartil 25(7):1179\u20131188","journal-title":"Osteoarthr Cartil"},{"issue":"8","key":"15_CR68","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s11926-013-0350-2","volume":"15","author":"RE Miller","year":"2013","unstructured":"Miller RE et al (2013) Genetically engineered mouse models reveal the importance of proteases as osteoarthritis drug targets. Curr Rheumatol Rep 15(8):350","journal-title":"Curr Rheumatol Rep"},{"issue":"2","key":"15_CR69","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.joca.2012.11.004","volume":"21","author":"RE Mitchell","year":"2013","unstructured":"Mitchell RE et al (2013) New tools for studying osteoarthritis genetics in zebrafish. Osteoarthr Cartil 21(2):269\u2013278","journal-title":"Osteoarthr Cartil"},{"key":"15_CR70","doi-asserted-by":"crossref","unstructured":"Moran CJ et al (2016) The benefits and limitations of animal models for translational research in cartilage repair. J Exp Orthop 3(1):1. Available at: http:\/\/www.jeo-esska.com\/content\/3\/1\/1 . Accessed 26 May 2017","DOI":"10.1186\/s40634-015-0037-x"},{"issue":"3","key":"15_CR71","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.rvsc.2014.09.011","volume":"97","author":"Maxim Moreau","year":"2014","unstructured":"Moreau M et al (2014) A medicinal herb-based natural health product improves the condition of a canine natural osteoarthritis model: a randomized placebo-controlled trial. Res Vet Sci 97(3):574\u2013581. Available at: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528814002483 . Accessed 26 May 2017","journal-title":"Research in Veterinary Science"},{"key":"15_CR72","doi-asserted-by":"crossref","first-page":"180453","DOI":"10.1155\/2013\/180453","volume":"2013","author":"M Moreau","year":"2013","unstructured":"Moreau M et al (2013) A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis. Biomed Res Int 2013:180453. Available at: http:\/\/www.hindawi.com\/journals\/bmri\/2013\/180453\/ . Accessed 26 May 2017","journal-title":"Biomed Res Int"},{"issue":"12","key":"15_CR73","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1002\/art.21423","volume":"52","author":"J Morko","year":"2005","unstructured":"Morko J et\u00a0al (2005) Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K. Arthritis Rheum 52(12):3713\u20133717","journal-title":"Arthritis Rheum"},{"issue":"12","key":"15_CR74","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.joca.2014.06.034","volume":"22","author":"RF Moyer","year":"2017","unstructured":"Moyer RF et al (2017) Osteoarthritis year in review 2014: mechanics\u00a0\u2013 basic and clinical studies in osteoarthritis. Osteoarthr Cartil 22(12):1989\u20132002. Available at: https:\/\/doi.org\/10.1016\/j.joca.2014.06.034","journal-title":"Osteoarthr Cartil"},{"issue":"15\u201316","key":"15_CR75","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1089\/ten.tea.2012.0385","volume":"19","author":"S Murab","year":"2013","unstructured":"Murab S et al (2013) Matrix-embedded cytokines to simulate osteoarthritis-like cartilage microenvironments. Tissue Eng A 19(15\u201316):1733\u20131753. Available at: http:\/\/online.liebertpub.com\/doi\/abs\/10.1089\/ten.tea.2012.0385","journal-title":"Tissue Eng A"},{"issue":"10","key":"15_CR76","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1002\/art.22921","volume":"56","author":"T Muraoka","year":"2007","unstructured":"Muraoka T et al (2007) Role of subchondral bone in osteoarthritis development: a comparative study of two strains of Guinea pigs with and without spontaneously occurring osteoarthritis. Arthritis Rheum 56(10):3366\u20133374","journal-title":"Arthritis Rheum"},{"issue":"2","key":"15_CR77","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jor.21515","volume":"30","author":"KD Novakofski","year":"2012","unstructured":"Novakofski KD, Torre CJ, Fortier LA (2012) Interleukin-1??, \u22126, and \u22128 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype. J Orthop Res 30(2):246\u2013251","journal-title":"J Orthop Res"},{"issue":"9","key":"15_CR78","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2746\/042516409X448481","volume":"41","author":"J Olive","year":"2009","unstructured":"Olive J et\u00a0al (2009) Imaging and histological features of central subchondral osteophytes in racehorses with metacarpophalangeal joint osteoarthritis. Equine Vet J 41(9):859\u2013864","journal-title":"Equine Vet J"},{"issue":"5","key":"15_CR79","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1249\/MSS.0b013e31827d1e06","volume":"45","author":"A Osawa","year":"2013","unstructured":"Osawa A et al (2013) The use of blood vessel-derived stem cells for meniscal regeneration and repair. Med Sci Sports Exerc 45(5):813\u2013823","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"15_CR80","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","volume":"8","author":"A Page-McCaw","year":"2007","unstructured":"Page-McCaw A, Ewald AJ, Werb Z (2007) Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8(3):221\u2013233","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"15_CR81","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00167-010-1052-1","volume":"18","author":"D Pape","year":"2010","unstructured":"Pape D et al (2010) Disease-specific clinical problems associated with the subchondral bone. Knee Surg Sports Traumatol Arthrosc 18(4):448\u2013462","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"2","key":"15_CR82","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.joca.2011.12.002","volume":"20","author":"E Pecchi","year":"2012","unstructured":"Pecchi E et al (2012) A potential role of chondroitin sulfate on bone in osteoarthritis: inhibition of prostaglandin E 2 and matrix metalloproteinases synthesis in interleukin-1\u03b2- stimulated osteoblasts. Osteoarthr Cartil 20(2):127\u2013135. Available at: https:\/\/doi.org\/10.1016\/j.joca.2011.12.002","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"15_CR83","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.joca.2011.12.017","volume":"20","author":"N Percie du Sert","year":"2012","unstructured":"Percie du Sert N (2012) Maximising the output of osteoarthritis research: the ARRIVE guidelines. Osteoarthr Cartil 20(4):253\u2013255","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"15_CR84","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/adma.201403354","volume":"27","author":"S Pina","year":"2015","unstructured":"Pina S, Oliveira JM, Reis RL (2015) Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review. Adv Mater (Deerfield Beach, Fla) 27(7):1143\u20131169","journal-title":"Adv Mater (Deerfield Beach, Fla)"},{"issue":"1","key":"15_CR85","first-page":"99","volume":"8","author":"KP Pritzker","year":"1989","unstructured":"Pritzker KP et al (1989) Rhesus macaques as an experimental model for degenerative arthritis. P R Health Sci J 8(1):99\u2013102","journal-title":"P R Health Sci J"},{"issue":"1","key":"15_CR86","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","volume":"14","author":"KPH Pritzker","year":"2006","unstructured":"Pritzker KPH et al (2006) Osteoarthritis cartilage histopathology: grading and staging. Osteoarthr Cartil 14(1):13\u201329","journal-title":"Osteoarthr Cartil"},{"key":"15_CR87","doi-asserted-by":"crossref","first-page":"23","DOI":"10.22203\/eCM.v009a04","volume":"9","author":"SN Redman","year":"2005","unstructured":"Redman SN, Oldfield SF, Archer CW (2005) Current strategies for articular cartilage repair. Eur Cell Mater 9:23\u201332","journal-title":"Eur Cell Mater"},{"issue":"10","key":"15_CR88","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrrheum.2013.121","volume":"9","author":"LN Reynard","year":"2013","unstructured":"Reynard LN, Loughlin J (2013) Insights from human genetic studies into the pathways involved in osteoarthritis. Nat Rev Rheumatol 9(10):573\u2013583. Available at: http:\/\/www.nature.com\/doifinder\/10.1038\/nrrheum.2013.121","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"15_CR89","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/art.23458","volume":"58","author":"FM Rogerson","year":"2008","unstructured":"Rogerson FM et al (2008) Evidence of a novel aggrecan-degrading activity in cartilage: studies of mice deficient in both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 58(6):1664\u20131673","journal-title":"Arthritis Rheum"},{"issue":"1","key":"15_CR90","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/art.20900","volume":"52","author":"M Sabatini","year":"2005","unstructured":"Sabatini M et al (2005) Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a Guinea pig model of osteoarthritis. Arthritis Rheum 52(1):171\u2013180","journal-title":"Arthritis Rheum"},{"issue":"3","key":"15_CR91","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/art.22427","volume":"56","author":"S Sahebjam","year":"2007","unstructured":"Sahebjam S, Khokha R, Mort JS (2007) Increased collagen and aggrecan degradation with age in the joints of Timp3(\u2212\/\u2212) mice. Arthritis Rheum 56(3):905\u2013909","journal-title":"Arthritis Rheum"},{"key":"15_CR92","doi-asserted-by":"publisher","unstructured":"Sanchez C et al (2016) Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis. Osteoarthr Cartil. Available at: https:\/\/doi.org\/10.1016\/j.joca.2017.02.797","DOI":"10.1016\/j.joca.2017.02.797"},{"issue":"2","key":"15_CR93","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/art.23159","volume":"58","author":"C Sanchez","year":"2008","unstructured":"Sanchez C et al (2008) Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone. Arthritis Rheum 58(2):442\u2013455","journal-title":"Arthritis Rheum"},{"issue":"11","key":"15_CR94","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.joca.2005.07.012","volume":"13","author":"C Sanchez","year":"2005","unstructured":"Sanchez C et al (2005) Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes. Osteoarthr Cartil 13(11):988\u2013997","journal-title":"Osteoarthr Cartil"},{"issue":"12","key":"15_CR95","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.joca.2011.09.004","volume":"19","author":"KS Santangelo","year":"2011","unstructured":"Santangelo KS, Bertone AL (2011) Effective reduction of the interleukin-1beta transcript in osteoarthritis-prone Guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis. Osteoarthr Cartil 19(12):1449\u20131457","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"15_CR96","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/ten.teb.2012.0727","volume":"19","author":"V\u00edtor E. Santo","year":"2013","unstructured":"Santo VE et al (2013) Controlled release strategies for bone, cartilage, and osteochondral engineering\u2013part II: challenges on the evolution from single to multiple bioactive factor delivery. Tissue Eng Part B Rev 19(4):327\u2013352. Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23249320 . Accessed 26 May 2017","journal-title":"Tissue Engineering Part B: Reviews"},{"issue":"1","key":"15_CR97","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/ar3735","volume":"14","author":"M Sato","year":"2012","unstructured":"Sato M et al (2012) Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain Guinea pigs with spontaneous osteoarthritis. Arthritis Res Ther 14(1):R31","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"15_CR98","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ijantimicag.2008.08.004","volume":"33","author":"Judith Sendzik","year":"2009","unstructured":"Sendzik J, Lode H, Stahlmann R (2009) Quinolone-induced arthropathy: an update focusing on new mechanistic and clinical data. Int J Antimicrob Agents 33(3):194\u2013200. Available at: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857908003531 . Accessed 26 May 2017","journal-title":"International Journal of Antimicrobial Agents"},{"issue":"5","key":"15_CR99","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jor.20799","volume":"27","author":"MA Silva Da","year":"2009","unstructured":"Da Silva MA et al (2009) Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage. J Orthop Res 27(5):593\u2013601","journal-title":"J Orthop Res"},{"key":"15_CR100","doi-asserted-by":"crossref","first-page":"928301","DOI":"10.1155\/2015\/928301","volume":"2015","author":"D Simon","year":"2015","unstructured":"Simon D et al (2015) The relationship between anterior cruciate ligament injury and osteoarthritis of the knee. Adv Orthop 2015:928301","journal-title":"Adv Orthop"},{"issue":"6","key":"15_CR101","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jor.1100130604","volume":"13","author":"R. Lane Smith","year":"1995","unstructured":"Smith RL et al (1995) Effects of fluid-induced shear on articular chondrocyte morphology and metabolism in vitro. J Orthop Res 13(6):824\u2013831. Available at: http:\/\/doi.wiley.com\/10.1002\/jor.1100130604 . Accessed 19 May 2017","journal-title":"Journal of Orthopaedic Research"},{"issue":"11","key":"15_CR102","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/1529-0131(199911)42:11<2381::AID-ANR17>3.0.CO;2-E","volume":"42","author":"R Stoop","year":"1999","unstructured":"Stoop R et al (1999) Type II collagen degradation in spontaneous osteoarthritis in C57Bl\/6 and BALB\/c mice. Arthritis Rheum 42(11):2381\u20132389","journal-title":"Arthritis Rheum"},{"issue":"5","key":"15_CR103","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bioeng.2007.07.014","volume":"24","author":"W Swieszkowski","year":"2007","unstructured":"Swieszkowski W et al (2007) Repair and regeneration of osteochondral defects in the articular joints. Biomol Eng 24(5):489\u2013495. Available at: http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1389034407000834","journal-title":"Biomol Eng"},{"issue":"5","key":"15_CR104","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jor.22003","volume":"30","author":"S Taniguchi","year":"2012","unstructured":"Taniguchi S et al (2012) Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley Guinea pigs. J Orthop Res: Off Publ Orthop Res Soc 30(5):673\u2013678","journal-title":"J Orthop Res: Off Publ Orthop Res Soc"},{"issue":"2","key":"15_CR105","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1208\/s12248-013-9454-x","volume":"15","author":"E Teeple","year":"2013","unstructured":"Teeple E et al (2013) Animal models of osteoarthritis: challenges of model selection and analysis. AAPS J 15(2):438\u2013446","journal-title":"AAPS J"},{"issue":"1","key":"15_CR106","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/dmm.016881","volume":"8","author":"S Thysen","year":"2015","unstructured":"Thysen S, Luyten FP, Lories RJU (2015) Targets, models and challenges in osteoarthritis research. Dis Model Mech 8(1):17\u201330. Available at: http:\/\/dmm.biologists.org\/cgi\/doi\/10.1242\/dmm.016881","journal-title":"Dis Model Mech"},{"key":"15_CR107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22203\/eCM.v017a01","volume":"17","author":"F Tortelli","year":"2009","unstructured":"Tortelli F, Cancedda R (2009) Three-dimensional cultures of osteogenic and chondrogenic cells: a tissue engineering approach to mimic bone and cartilage in vitro. Eur Cell Mater 17:1\u201314. Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19579210 . Accessed 26 May 2017","journal-title":"European Cells and Materials"},{"issue":"1","key":"15_CR108","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2191-219X-1-11","volume":"1","author":"JL Tremoleda","year":"2011","unstructured":"Tremoleda JL et al (2011) Imaging technologies for preclinical models of bone and joint disorders. EJNMMI Res 1(1):11","journal-title":"EJNMMI Res"},{"issue":"7","key":"15_CR109","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.joca.2007.11.008","volume":"16","author":"TN Trumble","year":"2008","unstructured":"Trumble TN et al (2008) Joint dependent concentrations of bone alkaline phosphatase in serum and synovial fluids of horses with osteochondral injury: an analytical and clinical validation. Osteoarthr Cartil 16(7):779\u2013786","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"15_CR110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/excr.2001.5448","volume":"273","author":"AC Tufan","year":"2002","unstructured":"Tufan AC et al (2002) AP-1 transcription factor complex is a target of signals from both WnT-7a and N-cadherin-dependent cell-cell adhesion complex during the regulation of limb mesenchymal chondrogenesis. Exp Cell Res 273(2):197\u2013203","journal-title":"Exp Cell Res"},{"issue":"DEC","key":"15_CR111","first-page":"1","volume":"5","author":"M Vazquez","year":"2014","unstructured":"Vazquez M et al (2014) A new method to investigate how mechanical loading of osteocytes controls osteoblasts. Front Endocrinol 5(DEC):1\u201319","journal-title":"Front Endocrinol"},{"issue":"1","key":"15_CR112","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0040-8166(02)00106-4","volume":"35","author":"W-G Wang","year":"2003","unstructured":"Wang W-G et al (2003) In vitro chondrogenesis of human bone marrow-derived mesenchymal progenitor cells in monolayer culture: activation by transfection with TGF-beta2. Tissue Cell 35(1):69\u201377","journal-title":"Tissue Cell"},{"issue":"4\u20135","key":"15_CR113","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1023\/A:1025344332099","volume":"19","author":"H Watanabe","year":"2002","unstructured":"Watanabe H, Yamada Y (2002) Chondrodysplasia of gene knockout mice for aggrecan and link protein. Glycoconj J 19(4\u20135):269\u2013273","journal-title":"Glycoconj J"},{"issue":"11","key":"15_CR114","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/art.1780401121","volume":"40","author":"L Wei","year":"1997","unstructured":"Wei L, Svensson O, Hjerpe A (1997) Correlation of morphologic and biochemical changes in the natural history of spontaneous osteoarthrosis in Guinea pigs. Arthritis Rheum 40(11):2075\u20132083","journal-title":"Arthritis Rheum"},{"issue":"5","key":"15_CR115","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.coph.2010.05.009","volume":"10","author":"A Wendler","year":"2010","unstructured":"Wendler A, Wehling M (2010) The translatability of animal models for clinical development: biomarkers and disease models. Curr Opin Pharmacol 10(5):601\u2013606","journal-title":"Curr Opin Pharmacol"},{"issue":"4","key":"15_CR116","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/sctm.16-0199","volume":"6","author":"MR Whitehouse","year":"2017","unstructured":"Whitehouse MR et al (2017) Repair of torn avascular meniscal cartilage using undifferentiated autologous mesenchymal stem cells: from in vitro optimization to a first-in-human study. Stem Cells Transl Med 6(4):1237\u20131248","journal-title":"Stem Cells Transl Med"},{"issue":"1","key":"15_CR117","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/230949900501300103","volume":"13","author":"K Yamamoto","year":"2005","unstructured":"Yamamoto K et al (2005) Morphological studies on the ageing and osteoarthritis of the articular cartilage in C57 black mice. J Orthop Surg (Hong Kong) 13(1):8\u201318","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"15_CR118","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.actbio.2014.10.021","volume":"12","author":"Le-Ping Yan","year":"2015","unstructured":"Yan L-P et al (2015) Bilayered silk\/silk-nanoCaP scaffolds for osteochondral tissue engineering: in vitro and in vivo assessment of biological performance. Acta Biomater 12:227\u2013241. Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25449920 . Accessed 26 May 2017","journal-title":"Acta Biomaterialia"},{"issue":"14","key":"15_CR119","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1016\/j.febslet.2014.05.033","volume":"588","author":"B Yang","year":"2014","unstructured":"Yang B et al (2014) Effect of microRNA-145 on IL-1\u03b2-induced cartilage degradation in human chondrocytes. FEBS Lett 588(14):2344\u20132352. Available at: https:\/\/doi.org\/10.1016\/j.febslet.2014.05.033","journal-title":"FEBS Lett"},{"issue":"5","key":"15_CR120","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/joca.2002.0530","volume":"10","author":"RD Young","year":"2002","unstructured":"Young RD et al (2002) Type II collagen deposition in cruciate ligament precedes osteoarthritis in the Guinea pig knee. Osteoarthr Cartil 10(5):420\u2013428","journal-title":"Osteoarthr Cartil"},{"key":"15_CR121","doi-asserted-by":"crossref","unstructured":"Yu XM et al (2015) MicroRNAs\u2019 involvement in osteoarthritis and the prospects for treatments. Evid Based Complement Alternat Med 2015:236179","DOI":"10.1155\/2015\/236179"},{"issue":"9","key":"15_CR122","doi-asserted-by":"crossref","first-page":"17729","DOI":"10.3390\/ijms140917729","volume":"14","author":"Z Zamli","year":"2013","unstructured":"Zamli Z et al (2013) Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease. Int J Mol Sci 14(9):17729\u201317743","journal-title":"Int J Mol Sci"},{"issue":"7","key":"15_CR123","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/jbm.b.32922","volume":"101","author":"J Zellner","year":"2013","unstructured":"Zellner J et\u00a0al (2013) Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone. J Biomed Mater Res B Appl Biomater 101(7):1133\u20131142","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"5","key":"15_CR124","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/jor.23079","volume":"34","author":"W Zhao","year":"2016","unstructured":"Zhao W et al (2016) Cartilage degeneration and excessive subchondral bone formation in spontaneous osteoarthritis involves altered TGF-beta signaling. J Orthop Res: Off Publ Orthop Res Soc 34(5):763\u2013770","journal-title":"J Orthop Res: Off Publ Orthop Res Soc"}],"container-title":["Advances in Experimental Medicine and Biology","Osteochondral Tissue Engineering"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-76735-2_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T13:35:47Z","timestamp":1571319347000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-76735-2_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319767345","9783319767352"],"references-count":124,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-76735-2_15","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}