{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:44:19Z","timestamp":1791092659402,"version":"4.1.0"},"publisher-location":"Cham","reference-count":59,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319767345","type":"print"},{"value":"9783319767352","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-76735-2_16","type":"book-chapter","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T15:38:00Z","timestamp":1525707480000},"page":"353-371","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Tissue Engineering Strategies for Osteochondral Repair"],"prefix":"10.1007","author":[{"given":"F. Raquel","family":"Maia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana R.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Miguel","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"issue":"4","key":"16_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1021\/ab500038y","volume":"1","author":"L-P Yan","year":"2015","unstructured":"Yan L-P et al (2015) Current concepts and challenges in osteochondral tissue engineering and regenerative medicine. ACS Biomater Sci Eng 1(4):183\u2013200","journal-title":"ACS Biomater Sci Eng"},{"issue":"6","key":"16_CR2","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1007\/s00167-011-1655-1","volume":"20","author":"S Panseri","year":"2012","unstructured":"Panseri S et al (2012) Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration. Knee Surg Sports Traumatol Arthrosc 20(6):1182\u20131191","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"7","key":"16_CR3","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1002\/term.2092","volume":"11","author":"SI Correia","year":"2017","unstructured":"Correia SI et al (2017) Posterior talar process as a suitable cell source for treatment of cartilage and osteochondral defects of the talus. J Tissue Eng Regen Med 11(7):1949\u20131962","journal-title":"J Tissue Eng Regen Med"},{"issue":"6","key":"16_CR4","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1007\/s00167-012-1910-0","volume":"20","author":"J Espregueira-Mendes","year":"2012","unstructured":"Espregueira-Mendes J et\u00a0al (2012) Osteochondral transplantation using autografts from the upper tibio-fibular joint for the treatment of knee cartilage lesions. Knee Surg Sports Traumatol Arthrosc 20(6):1136\u20131142","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"4","key":"16_CR5","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.arthro.2014.11.017","volume":"31","author":"E Kon","year":"2015","unstructured":"Kon E et al (2015) Scaffold-based cartilage treatments: with or without cells? A systematic review of preclinical and clinical evidence. Arthroscopy 31(4):767\u2013775","journal-title":"Arthroscopy"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2017.01.036","volume":"57","author":"J Yang","year":"2017","unstructured":"Yang J et\u00a0al (2017) Cell-laden hydrogels for osteochondral and cartilage tissue engineering. Acta Biomater 57:1\u201325","journal-title":"Acta Biomater"},{"key":"16_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-319-22345-2_1","volume":"881","author":"CG Jeong","year":"2015","unstructured":"Jeong CG, Atala A (2015) 3D printing and biofabrication for load bearing tissue engineering. Adv Exp Med Biol 881:3\u201314","journal-title":"Adv Exp Med Biol"},{"issue":"12","key":"16_CR8","doi-asserted-by":"publisher","first-page":"4983","DOI":"10.1016\/j.actbio.2014.08.022","volume":"10","author":"W Wang","year":"2014","unstructured":"Wang W et al (2014) An anti-inflammatory cell-free collagen\/resveratrol scaffold for repairing osteochondral defects in rabbits. Acta Biomater 10(12):4983\u20134995","journal-title":"Acta Biomater"},{"key":"16_CR9","doi-asserted-by":"publisher","first-page":"245","DOI":"10.4028\/www.scientific.net\/KEM.587.245","volume":"587","author":"LP Yan","year":"2014","unstructured":"Yan LP et al (2014) Silk fibroin\/Nano-CaP bilayered scaffolds for osteochondral tissue engineering. Key Eng Mater 587:245\u2013248","journal-title":"Key Eng Mater"},{"issue":"7","key":"16_CR10","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1177\/0363546517694159","volume":"45","author":"F Perdisa","year":"2017","unstructured":"Perdisa F et al (2017) One-step treatment for patellar cartilage defects with a cell-free osteochondral scaffold: a prospective clinical and MRI evaluation. Am J Sports Med 45(7):1581\u20131588","journal-title":"Am J Sports Med"},{"key":"16_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.biomaterials.2016.02.006","volume":"87","author":"TJ Levingstone","year":"2016","unstructured":"Levingstone TJ et al (2016) Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints. Biomaterials 87:69\u201381","journal-title":"Biomaterials"},{"issue":"3","key":"16_CR12","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00264-016-3118-2","volume":"40","author":"M Brix","year":"2016","unstructured":"Brix M et al (2016) Successful osteoconduction but limited cartilage tissue quality following osteochondral repair by a cell-free multilayered nano-composite scaffold at the knee. Int Orthop 40(3):625\u2013632","journal-title":"Int Orthop"},{"issue":"3","key":"16_CR13","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1302\/0301-620X.97B3.34555","volume":"97-b","author":"P Verdonk","year":"2015","unstructured":"Verdonk P et al (2015) Treatment of osteochondral lesions in the knee using a cell-free scaffold. Bone Joint J 97-b(3):318\u2013323","journal-title":"Bone Joint J"},{"issue":"8","key":"16_CR14","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00132-016-3267-4","volume":"45","author":"N Stadler","year":"2016","unstructured":"Stadler N, Trieb K (2016) Osteochondritis dissecans of the medial femoral condyle : new cell-free scaffold as a treatment option. Orthopade 45(8):701\u2013705","journal-title":"Orthopade"},{"issue":"6","key":"16_CR15","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s00167-013-2493-0","volume":"22","author":"P Hindle","year":"2014","unstructured":"Hindle P et al (2014) Autologous osteochondral mosaicplasty or TruFit\u2122 plugs for cartilage repair. Knee Surg Sports Traumatol Arthrosc 22(6):1235\u20131240","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"16_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40634-014-0010-0","volume":"1","author":"E Kon","year":"2014","unstructured":"Kon E et al (2014) Clinical results of multilayered biomaterials for osteochondral regeneration. J Exp Orthop 1:10","journal-title":"J Exp Orthop"},{"key":"16_CR17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.actbio.2015.09.026","volume":"28","author":"NJ Chang","year":"2015","unstructured":"Chang NJ et al (2015) Positive effects of cell-free porous PLGA implants and early loading exercise on hyaline cartilage regeneration in rabbits. Acta Biomater 28:128\u2013137","journal-title":"Acta Biomater"},{"issue":"1","key":"16_CR18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.arthro.2016.06.035","volume":"33","author":"H Sofu","year":"2017","unstructured":"Sofu H et al (2017) Results of hyaluronic acid-based cell-free scaffold application in combination with microfracture for the treatment of osteochondral lesions of the knee: 2-year comparative study. Arthroscopy 33(1):209\u2013216","journal-title":"Arthroscopy"},{"issue":"5","key":"16_CR19","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1007\/s10856-015-5517-0","volume":"26","author":"HL Fermor","year":"2015","unstructured":"Fermor HL et al (2015) Development and characterisation of a decellularised bovine osteochondral biomaterial for cartilage repair. J Mater Sci Mater Med 26(5):186","journal-title":"J Mater Sci Mater Med"},{"issue":"7\u20138","key":"16_CR20","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1089\/ten.tea.2015.0285","volume":"22","author":"M Nogami","year":"2016","unstructured":"Nogami M et al (2016) A human Amnion-derived extracellular matrix-coated cell-free scaffold for cartilage repair: in vitro and in vivo studies. Tissue Eng Part A 22(7\u20138):680\u2013688","journal-title":"Tissue Eng Part A"},{"issue":"3","key":"16_CR21","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.3892\/mmr.2016.4795","volume":"13","author":"H Li","year":"2016","unstructured":"Li H et al (2016) Osteochondral repair with synovial membrane-derived mesenchymal stem cells. Mol Med Rep 13(3):2071\u20132077","journal-title":"Mol Med Rep"},{"issue":"4","key":"16_CR22","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/1947603515627342","volume":"7","author":"M Itokazu","year":"2016","unstructured":"Itokazu M et al (2016) Transplantation of scaffold-free cartilage-like cell-sheets made from human bone marrow mesenchymal stem cells for cartilage repair: a preclinical study. Cartilage 7(4):361\u2013372","journal-title":"Cartilage"},{"issue":"4","key":"16_CR23","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s00776-014-0574-7","volume":"19","author":"K Oda","year":"2014","unstructured":"Oda K et al (2014) Comparison of repair between cartilage and osteocartilage defects in rabbits using similarly manipulated scaffold-free cartilage-like constructs. J Orthop Sci 19(4):637\u2013645","journal-title":"J Orthop Sci"},{"issue":"2","key":"16_CR24","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/00007890-196803000-00009","volume":"6","author":"AJ Friedenstein","year":"1968","unstructured":"Friedenstein AJ et al (1968) Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6(2):230\u2013247","journal-title":"Transplantation"},{"issue":"8","key":"16_CR25","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1002\/jor.23467","volume":"35","author":"BanuPriya Sridharan","year":"2016","unstructured":"Sridharan B et al (2017) In vivo evaluation of stem cell aggregates on osteochondral regeneration. J Orthop Res 35:1606\u201316","journal-title":"Journal of Orthopaedic Research"},{"issue":"1","key":"16_CR26","first-page":"40","volume":"6","author":"R Nansai","year":"2011","unstructured":"Nansai R et al (2011) Surface morphology and stiffness of cartilage-like tissue repaired with a scaffold-free tissue engineered construct. J Biomed Sci Eng 6(1):40\u201348","journal-title":"J Biomed Sci Eng"},{"key":"16_CR27","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13018-014-0098-z","volume":"9","author":"K Ishihara","year":"2014","unstructured":"Ishihara K et al (2014) Simultaneous regeneration of full-thickness cartilage and subchondral bone defects in vivo using a three-dimensional scaffold-free autologous construct derived from high-density bone marrow-derived mesenchymal stem cells. J Orthop Surg Res 9:98","journal-title":"J Orthop Surg Res"},{"key":"16_CR28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13018-015-0173-0","volume":"10","author":"D Murata","year":"2015","unstructured":"Murata D et al (2015) A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells. J Orthop Surg Res 10:35","journal-title":"J Orthop Surg Res"},{"issue":"4","key":"16_CR29","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1089\/biores.2012.0231","volume":"1","author":"GA Whitney","year":"2012","unstructured":"Whitney GA et al (2012) Methods for producing scaffold-free engineered cartilage sheets from auricular and articular chondrocyte cell sources and attachment to porous tantalum. Biores Open Access 1(4):157\u2013165","journal-title":"Biores Open Access"},{"issue":"17\u201318","key":"16_CR30","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1089\/ten.tea.2013.0414","volume":"20","author":"K Shimomura","year":"2014","unstructured":"Shimomura K et al (2014) Osteochondral repair using a scaffold-free tissue-engineered construct derived from synovial mesenchymal stem cells and a hydroxyapatite-based artificial bone. Tissue Eng Part A 20(17\u201318):2291\u20132304","journal-title":"Tissue Eng Part A"},{"issue":"36","key":"16_CR31","doi-asserted-by":"publisher","first-page":"6123","DOI":"10.1016\/j.biomaterials.2006.07.034","volume":"27","author":"JM Oliveira","year":"2006","unstructured":"Oliveira JM et al (2006) Novel hydroxyapatite\/chitosan bilayered scaffold for osteochondral tissue-engineering applications: scaffold design and its performance when seeded with goat bone marrow stromal cells. Biomaterials 27(36):6123\u20136137","journal-title":"Biomaterials"},{"key":"16_CR32","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.actbio.2014.10.021","volume":"12","author":"LP Yan","year":"2015","unstructured":"Yan LP et al (2015) Bilayered silk\/silk-nanoCaP scaffolds for osteochondral tissue engineering: in vitro and in vivo assessment of biological performance. Acta Biomater 12:227\u2013241","journal-title":"Acta Biomater"},{"issue":"10","key":"16_CR33","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s11926-014-0452-5","volume":"16","author":"S Grassel","year":"2014","unstructured":"Grassel S, Lorenz J (2014) Tissue-engineering strategies to repair chondral and osteochondral tissue in osteoarthritis: use of mesenchymal stem cells. Curr Rheumatol Rep 16(10):452","journal-title":"Curr Rheumatol Rep"},{"key":"16_CR34","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.eurpolymj.2014.11.024","volume":"65","author":"E Cal\u00f3","year":"2015","unstructured":"Cal\u00f3 E, Khutoryanskiy VV (2015) Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J 65:252\u2013267","journal-title":"Eur Polym J"},{"issue":"1","key":"16_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/acs.biomac.6b01619","volume":"18","author":"J Radhakrishnan","year":"2017","unstructured":"Radhakrishnan J et\u00a0al (2017) Injectable and 3D bioprinted polysaccharide hydrogels: from cartilage to osteochondral tissue engineering. Biomacromolecules 18(1):1\u201326","journal-title":"Biomacromolecules"},{"key":"16_CR36","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1038\/srep03553","volume":"3","author":"JH Lai","year":"2013","unstructured":"Lai JH et al (2013) Stem cells catalyze cartilage formation by neonatal articular chondrocytes in 3D biomimetic hydrogels. Sci Rep 3:3553","journal-title":"Sci Rep"},{"issue":"11\u201312","key":"16_CR37","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1089\/ten.tea.2011.0543","volume":"18","author":"X Cui","year":"2012","unstructured":"Cui X et al (2012) Direct human cartilage repair using three-dimensional bioprinting technology. Tissue Eng Part A 18(11\u201312):1304\u20131312","journal-title":"Tissue Eng Part A"},{"issue":"4","key":"16_CR38","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/9\/4\/045012","volume":"9","author":"DA Bichara","year":"2014","unstructured":"Bichara DA et al (2014) Osteochondral defect repair using a polyvinyl alcohol-polyacrylic acid (PVA-PAAc) hydrogel. Biomed Mater 9(4):045012","journal-title":"Biomed Mater"},{"issue":"2","key":"16_CR39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2217\/rme.14.77","volume":"10","author":"L Girolamo de","year":"2015","unstructured":"de Girolamo L et al (2015) Repair of osteochondral defects in the minipig model by OPF hydrogel loaded with adipose-derived mesenchymal stem cells. Regen Med 10(2):135\u2013151","journal-title":"Regen Med"},{"key":"16_CR40","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/1471-2474-15-320","volume":"15","author":"Y Inagaki","year":"2014","unstructured":"Inagaki Y et al (2014) Effects of culture on PAMPS\/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1\/2 cells: in vitro experimental study. BMC Musculoskelet Disord 15:320","journal-title":"BMC Musculoskelet Disord"},{"key":"16_CR41","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.msec.2013.09.003","volume":"34","author":"L Zeng","year":"2014","unstructured":"Zeng L et al (2014) Effect of microcavitary alginate hydrogel with different pore sizes on chondrocyte culture for cartilage tissue engineering. Mater Sci Eng C 34:168\u2013175","journal-title":"Mater Sci Eng C"},{"issue":"12","key":"16_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145080","volume":"10","author":"D Gothard","year":"2015","unstructured":"Gothard D et al (2015) In vivo assessment of bone regeneration in alginate\/bone ECM hydrogels with incorporated skeletal stem cells and single growth factors. PLoS One 10(12):e0145080","journal-title":"PLoS One"},{"issue":"1","key":"16_CR43","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1021\/bm4016495","volume":"15","author":"KB Fonseca","year":"2014","unstructured":"Fonseca KB et al (2014) Injectable MMP-sensitive alginate hydrogels as hMSC delivery systems. Biomacromolecules 15(1):380\u2013390","journal-title":"Biomacromolecules"},{"issue":"1","key":"16_CR44","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/jbm.b.32978","volume":"102","author":"Q Zeng","year":"2014","unstructured":"Zeng Q et al (2014) Bioglass\/alginate composite hydrogel beads as cell carriers for bone regeneration. J Biomed Mater Res B Appl Biomater 102(1):42\u201351","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"22","key":"16_CR45","doi-asserted-by":"publisher","first-page":"20110","DOI":"10.1021\/am505723k","volume":"6","author":"B Choi","year":"2014","unstructured":"Choi B et al (2014) Cartilaginous extracellular matrix-modified chitosan hydrogels for cartilage tissue engineering. ACS Appl Mater Interfaces 6(22):20110\u201320121","journal-title":"ACS Appl Mater Interfaces"},{"key":"16_CR46","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12917-014-0197-4","volume":"10","author":"EA Martins","year":"2014","unstructured":"Martins EA et al (2014) Evaluation of chitosan-GP hydrogel biocompatibility in osteochondral defects: an experimental approach. BMC Vet Res 10:197","journal-title":"BMC Vet Res"},{"issue":"Supplement 1","key":"16_CR47","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1016\/j.joca.2017.02.767","volume":"25","author":"C Boyer","year":"2017","unstructured":"Boyer C et al (2017) Si-HPMC\/Si-Chitosan hybrid hydrogel for cartilage regenerative medicine: from in vitro to in vivo assessments in nude mice and canine model of osteochondral defects. Osteoarthr Cartil 25(Supplement 1):S77","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"16_CR48","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1002\/jbm.b.33011","volume":"102","author":"T Yuan","year":"2014","unstructured":"Yuan T et al (2014) Collagen hydrogel as an immunomodulatory scaffold in cartilage tissue engineering. J Biomed Mater Res B Appl Biomater 102(2):337\u2013344","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"16_CR49","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1016\/j.ijbiomac.2017.03.142","volume":"104","author":"N Mohan","year":"2017","unstructured":"Mohan N et al (2017) Chitosan-hyaluronic acid hydrogel for cartilage repair. Int J Biol Macromol 104:1936\u20131945","journal-title":"Int J Biol Macromol"},{"key":"16_CR50","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.biomaterials.2015.02.079","volume":"54","author":"PA Parmar","year":"2015","unstructured":"Parmar PA et al (2015) Collagen-mimetic peptide-modifiable hydrogels for articular cartilage regeneration. Biomaterials 54:213\u2013225","journal-title":"Biomaterials"},{"issue":"1","key":"16_CR51","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/jbm.b.31686","volume":"95","author":"P-HG Chao","year":"2010","unstructured":"Chao P-HG et al (2010) Silk hydrogel for cartilage tissue engineering. J Biomed Mater Res B Appl Biomater 95(1):84\u201390","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"16_CR52","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.triboint.2014.11.024","volume":"89","author":"M Parkes","year":"2015","unstructured":"Parkes M et al (2015) Tribology-optimised silk protein hydrogels for articular cartilage repair. Tribol Int 89:9\u201318","journal-title":"Tribol Int"},{"key":"16_CR53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.actbio.2014.09.032","volume":"11","author":"S Yodmuang","year":"2015","unstructured":"Yodmuang S et al (2015) Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair. Acta Biomater 11:27\u201336","journal-title":"Acta Biomater"},{"key":"16_CR54","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jmbbm.2016.07.007","volume":"64","author":"J Wu","year":"2016","unstructured":"Wu J et\u00a0al (2016) Rheological, mechanical and degradable properties of injectable chitosan\/silk fibroin\/hydroxyapatite\/glycerophosphate hydrogels. J Mech Behav Biomed Mater 64:161\u2013172","journal-title":"J Mech Behav Biomed Mater"},{"key":"16_CR55","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.msec.2015.03.014","volume":"51","author":"J Ming","year":"2015","unstructured":"Ming J et\u00a0al (2015) Silk fibroin\/sodium alginate fibrous hydrogels regulated hydroxyapatite crystal growth. Mater Sci Eng C 51:287\u2013293","journal-title":"Mater Sci Eng C"},{"issue":"1","key":"16_CR56","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1089\/ten.tec.2011.0060","volume":"18","author":"NE Fedorovich","year":"2012","unstructured":"Fedorovich NE et al (2012) Biofabrication of osteochondral tissue equivalents by printing topologically defined, cell-laden hydrogel scaffolds. Tissue Eng Part C Methods 18(1):33\u201344","journal-title":"Tissue Eng Part C Methods"},{"issue":"5","key":"16_CR57","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1021\/acs.biomac.5b00188","volume":"16","author":"K Markstedt","year":"2015","unstructured":"Markstedt K et al (2015) 3D bioprinting human chondrocytes with Nanocellulose-alginate bioink for cartilage tissue engineering applications. Biomacromolecules 16(5):1489\u20131496","journal-title":"Biomacromolecules"},{"issue":"6","key":"16_CR58","doi-asserted-by":"publisher","first-page":"064001","DOI":"10.1088\/0957-4484\/27\/6\/064001","volume":"27","author":"B Holmes","year":"2016","unstructured":"Holmes B et al (2016) A synergistic approach to the design, fabrication and evaluation of 3D printed micro and nano featured scaffolds for vascularized bone tissue repair. Nanotechnology 27(6):064001\u2013064001","journal-title":"Nanotechnology"},{"key":"16_CR59","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12891-016-1130-8","volume":"17","author":"X Ren","year":"2016","unstructured":"Ren X et al (2016) Engineering zonal cartilage through bioprinting collagen type II hydrogel constructs with biomimetic chondrocyte density gradient. BMC Musculoskelet Disord 17:301","journal-title":"BMC Musculoskelet Disord"}],"container-title":["Advances in Experimental Medicine and Biology","Osteochondral Tissue Engineering"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-76735-2_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T04:10:28Z","timestamp":1527221428000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-76735-2_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319767345","9783319767352"],"references-count":59,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-76735-2_16","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}