{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T15:46:02Z","timestamp":1743090362245,"version":"3.40.3"},"publisher-location":"Cham","reference-count":20,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319787220"},{"type":"electronic","value":"9783319787237"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-78723-7_7","type":"book-chapter","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T05:16:28Z","timestamp":1522127788000},"page":"83-95","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inspecting the Role of PI3K\/AKT Signaling Pathway in Cancer Development Using an In Silico Modeling and Simulation Approach"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7223-9035","authenticated-orcid":false,"given":"Pedro Pablo","family":"Gonz\u00e1lez-P\u00e9rez","sequence":"first","affiliation":[]},{"given":"Maura","family":"C\u00e1rdenas-Garc\u00eda","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"7_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ceb.2017.02.007","volume":"45","author":"EC Lien","year":"2017","unstructured":"Lien, E.C., Dibble, C.C., Toker, A.: PI3K signaling in cancer: beyond AKT. Curr. Opin. Cell Biol. 45, 62\u201371 (2017). https:\/\/doi.org\/10.1016\/j.ceb.2017.02.007","journal-title":"Curr. Opin. Cell Biol."},{"issue":"6","key":"7_CR2","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nbt0606-667","volume":"24","author":"R Alves","year":"2006","unstructured":"Alves, R., Antunes, F., Salvador, A.: Tools for kinetic modeling of biochemical networks. Nat. Biotechnol. 24(6), 667\u2013672 (2006). https:\/\/doi.org\/10.1038\/nbt0606-667","journal-title":"Nat. Biotechnol."},{"doi-asserted-by":"crossref","unstructured":"Ciocchetta, F., Duguid, A., Guerriero, M.L.: A compartmental model of the cAMP\/PKA\/MAPK pathway in bio-PEPA. In: Third Workshop on Membrane Computing and Biologically Inspired Process Calculi (MeCBIC) (2009). http:\/\/dx.doi.org\/10.4204\/EPTCS.11.5","key":"7_CR3","DOI":"10.4204\/EPTCS.11.5"},{"issue":"36","key":"7_CR4","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.1137\/070692017","volume":"30","author":"RA Kerr","year":"2008","unstructured":"Kerr, R.A., Bartol, T.M., Kaminsky, B., Dittrich, M., Chang, J.C., Baden, S.B., Sejnowski, T.J., Stiles, J.R.: Fast Monte Carlo simulation methods for biological reaction-diffusion systems in solution and on surfaces. SIAM J. Sci. Comput. 30(36), 3126\u20133149 (2008). https:\/\/doi.org\/10.1137\/070692017","journal-title":"SIAM J. Sci. Comput."},{"issue":"24","key":"7_CR5","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1093\/bioinformatics\/btl485","volume":"22","author":"S Hoops","year":"2006","unstructured":"Hoops, S., Sahle, S., Gauges, R., Lee, C., Pahle, J., Simus, N., Singhal, M., Xu, L., Mendes, P., Kummer, U.: COPASI: a complex pathway simulator. Bioinformatics 22(24), 3067\u20133074 (2006). https:\/\/doi.org\/10.1093\/bioinformatics\/btl485","journal-title":"Bioinformatics"},{"key":"7_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/B978-0-12-388403-9.00008-4","volume":"110","author":"AE Cowan","year":"2012","unstructured":"Cowan, A.E., Moraru, I.I., Schaff, J.C., Slepchenko, B.M., Loew, L.M.: Spatial modeling of cell signaling networks. Methods Cell Biol. 110, 195\u2013221 (2012). https:\/\/doi.org\/10.1016\/B978-0-12-388403-9.00008-4","journal-title":"Methods Cell Biol."},{"key":"7_CR7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/B978-0-12-388403-9.00013-8","volume":"110","author":"M Swat","year":"2012","unstructured":"Swat, M., Thomas, G.L., Belmonte, J.M., Shirinifard, A., Hmeljak, D., Glazier, J.A.: Multi-scale modeling of tissues using CompuCell 3D. Methods Cell Biol. 110, 325\u2013366 (2012). https:\/\/doi.org\/10.1016\/B978-0-12-388403-9.00013-8","journal-title":"Methods Cell Biol."},{"issue":"3","key":"7_CR8","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1057\/jos.2012.28","volume":"27","author":"PP Gonz\u00e1lez-P\u00e9rez","year":"2013","unstructured":"Gonz\u00e1lez-P\u00e9rez, P.P., Omicini, A., Sbaraglia, M.: A biochemically inspired coordination-based model for simulating intracellular signalling pathway. J. Simul. 27(3), 216\u2013226 (2013). https:\/\/doi.org\/10.1057\/jos.2012.28","journal-title":"J. Simul."},{"key":"7_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4137\/BBI.S38075","volume":"10","author":"M C\u00e1rdenas-Garc\u00eda","year":"2016","unstructured":"C\u00e1rdenas-Garc\u00eda, M., Gonz\u00e1lez-P\u00e9rez, P.P., Montagna, S., Cort\u00e9s S\u00e1nchez, O., Caballero, E.H.: Modeling intercellular communication as a survival strategy of cancer cells: an in silico approach on a flexible bioinformatics framework. Bioinform. Biol. Insights 10, 5\u201318 (2016). https:\/\/doi.org\/10.4137\/BBI.S38075","journal-title":"Bioinform. Biol. Insights"},{"issue":"1","key":"7_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1145\/2363.2433","volume":"7","author":"D Gelernter","year":"1985","unstructured":"Gelernter, D.: Generative communication in Linda. ACM Trans. Program. Lang. Syst. 7(1), 80\u2013112 (1985). https:\/\/doi.org\/10.1145\/2363.2433","journal-title":"ACM Trans. Program. Lang. Syst."},{"issue":"25","key":"7_CR11","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1021\/j100540a008","volume":"81","author":"DT Gillespie","year":"1977","unstructured":"Gillespie, D.T.: Exact stochastic simulation of coupled chemical reactions. J. Phys. Chem. 81(25), 2340\u20132361 (1977). https:\/\/doi.org\/10.1021\/j100540a008","journal-title":"J. Phys. Chem."},{"issue":"1","key":"7_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrc969","volume":"3","author":"J Downward","year":"2013","unstructured":"Downward, J.: Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3(1), 11\u201322 (2013). https:\/\/doi.org\/10.1038\/nrc969","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"7_CR13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1634\/theoncologist.4-3-263","volume":"4","author":"DS Goodsell","year":"1999","unstructured":"Goodsell, D.S.: The molecular perspective: the ras oncogene. Oncologist 4(3), 263\u2013264 (1999)","journal-title":"Oncologist"},{"issue":"5573","key":"7_CR14","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1126\/science.1071550","volume":"296","author":"SR Neves","year":"2002","unstructured":"Neves, S.R., Ram, P.T., Iyengar, R.: G protein pathways. Science 296(5573), 1636\u20131639 (2002). https:\/\/doi.org\/10.1126\/science.1071550","journal-title":"Science"},{"issue":"2\u20133","key":"7_CR15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0303-2647(02)00094-1","volume":"68","author":"PP Gonz\u00e1lez-P\u00e9rez","year":"2003","unstructured":"Gonz\u00e1lez-P\u00e9rez, P.P., C\u00e1rdenas, M., Camacho, D., Franyuti, A., Rosas, O., Lag\u00fanez-Otero, J.: Cellulat: an agent-based intracellular signalling model. Biosystems 68(2\u20133), 171\u2013185 (2003). https:\/\/doi.org\/10.1016\/S0303-2647(02)00094-1","journal-title":"Biosystems"},{"issue":"518","key":"7_CR16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ab.2016.11.001","volume":"1","author":"ML Reyton-Gonz\u00e1lez","year":"2017","unstructured":"Reyton-Gonz\u00e1lez, M.L., Cornell-Kennon, S., Schaefer, E., Kuzmic, P.: An algebraic model to determine substrate kinetic parameters by global nonlinear fit of progress curves. Anal. Biochem. 1(518), 16\u201324 (2017). https:\/\/doi.org\/10.1016\/j.ab.2016.11.001","journal-title":"Anal. Biochem."},{"issue":"2","key":"7_CR17","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1042\/BJ20140921","volume":"467","author":"J Azevedo-Silva","year":"2015","unstructured":"Azevedo-Silva, J., Queir\u00f3s, O., Ribeiro, A., Baltazar, F., Young, K.H., Pedersen, P.L., Preto, A., Casal, M.: The cytotoxicity of 3-bromopyruvate in breast c\u00e1ncer cells depends on extracelular pH. Biochem. J. 467(2), 247\u2013258 (2015). https:\/\/doi.org\/10.1042\/BJ20140921","journal-title":"Biochem. J."},{"issue":"6","key":"7_CR18","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.cdp.2007.10.010","volume":"31","author":"D Blokh","year":"2007","unstructured":"Blokh, D., Stambler, I., Afrimzon, E., Shafran, Y., Korech, E., Sandbank, J., Orda, R., Zurgil, N., Deutsch, M.: The information-theory analysis of Michaelis-menten constants for detection of breast c\u00e1ncer. Cancer Detec. Prev. 31(6), 489\u2013498 (2007). https:\/\/doi.org\/10.1016\/j.cdp.2007.10.010","journal-title":"Cancer Detec. Prev."},{"issue":"6","key":"7_CR19","doi-asserted-by":"publisher","first-page":"R616","DOI":"10.1186\/bcr922","volume":"6","author":"A Paradiso","year":"2004","unstructured":"Paradiso, A., Cardone, R.A., Bellizzi, A., Bagorda, A., Guerro, L., Tommasino, M., Casavola, V., Reshkin, S.J.: The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasi\u00f3n in MDA-MB-435 cells. Breast Cancer Res. 6(6), R616\u2013R628 (2004). https:\/\/doi.org\/10.1186\/bcr922","journal-title":"Breast Cancer Res."},{"key":"7_CR20","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1476-4598-10-76","volume":"10","author":"J Fritz","year":"2011","unstructured":"Fritz, J., Dwyer-Nield, L., Malkinson, A.M.: Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation. Mol. Cancer 10, 76\u201396 (2011). https:\/\/doi.org\/10.1186\/1476-4598-10-76","journal-title":"Mol. Cancer"}],"container-title":["Lecture Notes in Computer Science","Bioinformatics and Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-78723-7_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T15:15:33Z","timestamp":1709824533000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-319-78723-7_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319787220","9783319787237"],"references-count":20,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-78723-7_7","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"28 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"IWBBIO","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Bioinformatics and Biomedical Engineering","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Granada","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Spain","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2018","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"25 April 2018","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"27 April 2018","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"6","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"iwbbio2018","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/iwbbio.ugr.es\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}