{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:36:06Z","timestamp":1767983766377,"version":"3.49.0"},"publisher-location":"Cham","reference-count":36,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319911366","type":"print"},{"value":"9783319911373","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-91137-3_5","type":"book-chapter","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T10:52:24Z","timestamp":1540378344000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Characterization of Equilibrative Nucleoside Transporters in the Rat Carotid Body and Their Regulation by Chronic Hypoxia"],"prefix":"10.1007","author":[{"given":"Shaima","family":"Salman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin A.","family":"Nurse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"5_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.resp.2012.06.016","volume":"185","author":"A Bairam","year":"2013","unstructured":"Bairam A, Niane LM, Joseph V (2013) Role of ATP and adenosine on carotid body function during development. Respir Physiol Neurobiol 185:57\u201366","journal-title":"Respir Physiol Neurobiol"},{"key":"5_CR2","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s00424-003-1103-2","volume":"447","author":"SA Baldwin","year":"2004","unstructured":"Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (2004) The equilibrative nucleoside transporter family, SLC29. Pflugers Arch 447:735\u2013743","journal-title":"Pflugers Arch"},{"key":"5_CR3","doi-asserted-by":"publisher","first-page":"15880","DOI":"10.1074\/jbc.M414337200","volume":"280","author":"SA Baldwin","year":"2005","unstructured":"Baldwin SA, Yao SY, Hyde RJ, Ng AM, Foppolo S et al (2005) Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem 280:15880\u201315887","journal-title":"J Biol Chem"},{"key":"5_CR4","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bbrc.2004.07.081","volume":"322","author":"J Buttigieg","year":"2004","unstructured":"Buttigieg J, Nurse CA (2004) Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body. Biochem Biophys Res Commun 322:82\u201387","journal-title":"Biochem Biophys Res Commun"},{"key":"5_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1161\/01.RES.0000172568.49367.f8","volume":"97","author":"P Casanello","year":"2005","unstructured":"Casanello P, Torres A, Sanhueza F, Gonzalez M, Farias M et al (2005) Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium. Circ Res 97:16\u201324","journal-title":"Circ Res"},{"key":"5_CR6","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.cardiores.2003.11.031","volume":"61","author":"N Chaudary","year":"2004","unstructured":"Chaudary N, Naydenova Z, Shuralyova I, Coe IR (2004) Hypoxia regulates the adenosine transporter, mENT1, in the murine cardiomyocyte cell line, HL-1. Cardiovasc Res 61:780\u2013788","journal-title":"Cardiovasc Res"},{"key":"5_CR7","doi-asserted-by":"publisher","first-page":"13596","DOI":"10.1074\/jbc.270.23.13596","volume":"270","author":"M Che","year":"1995","unstructured":"Che M, Ortiz DF, Arias IM (1995) Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. J Biol Chem 270:13596\u201313599","journal-title":"J Biol Chem"},{"key":"5_CR8","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1111\/j.1471-4159.2004.02380.x","volume":"89","author":"SV Conde","year":"2004","unstructured":"Conde SV, Monteiro EC (2004) Hypoxia induces adenosine release from the rat carotid body. J Neurochem 89:1148\u20131156","journal-title":"J Neurochem"},{"key":"5_CR9","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1113\/jphysiol.2007.144261","volume":"585","author":"SV Conde","year":"2007","unstructured":"Conde SV, Obeso A, Gonzalez C (2007) Low glucose effects on rat carotid body chemoreceptor cells\u2019 secretory responses and action potential frequency in the carotid sinus nerve. J Physiol 585:721\u2013730","journal-title":"J Physiol"},{"key":"5_CR10","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1111\/j.1471-4159.2008.05704.x","volume":"107","author":"SV Conde","year":"2008","unstructured":"Conde SV, Gonzalez C, Batuca JR, Monteiro EC, Obeso A (2008) An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells. J Neurochem 107:1369\u20131381","journal-title":"J Neurochem"},{"key":"5_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-90-481-2259-2_17","volume":"648","author":"SV Conde","year":"2009","unstructured":"Conde SV, Monteiro EC, Obeso A, Gonzalez C (2009) Adenosine in peripheral chemoreception: new insights into a historically overlooked molecule--invited article. Adv Exp Med Biol 648:145\u2013159","journal-title":"Adv Exp Med Biol"},{"issue":"112","key":"5_CR12","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1152\/japplphysiol.01617.2011","volume":"1985","author":"SV Conde","year":"2012","unstructured":"Conde SV, Monteiro EC, Rigual R, Obeso A, Gonzalez C (2012a) Hypoxic intensity: a determinant for the contribution of ATP and adenosine to the genesis of carotid body chemosensory activity. J Appl Physiol 1985(112):2002\u20132010","journal-title":"J Appl Physiol"},{"key":"5_CR13","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1124\/mol.112.081216","volume":"82","author":"SV Conde","year":"2012","unstructured":"Conde SV, Ribeiro MJ, Obeso A, Rigual R, Monteiro EC, Gonzalez C (2012b) Chronic caffeine intake in adult rat inhibits carotid body sensitization produced by chronic sustained hypoxia but maintains intact chemoreflex output. Mol Pharmacol 82:1056\u20131065","journal-title":"Mol Pharmacol"},{"key":"5_CR14","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1111\/j.1476-5381.1993.tb13891.x","volume":"110","author":"GP Connolly","year":"1993","unstructured":"Connolly GP, Stone TW, Brown F (1993) Characterization of the adenosine receptors of the rat superior cervical ganglion. Br J Pharmacol 110:854\u2013860","journal-title":"Br J Pharmacol"},{"key":"5_CR15","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1084\/jem.20050177","volume":"202","author":"HK Eltzschig","year":"2005","unstructured":"Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D et al (2005) HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med 202:1493\u20131505","journal-title":"J Exp Med"},{"key":"5_CR16","first-page":"549","volume":"475","author":"EB Gauda","year":"2000","unstructured":"Gauda EB (2000) Expression and localization of A2a and A1-adenosine receptor genes in the rat carotid body and petrosal ganglia. A2a and A1-adenosine receptor mRNAs in the rat carotid body. Adv Exp Med Biol 475:549\u2013558","journal-title":"Adv Exp Med Biol"},{"key":"5_CR17","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","volume":"74","author":"C Gonzalez","year":"1994","unstructured":"Gonzalez C, Almaraz L, Obeso A, Rigual R (1994) Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev 74:829\u2013898","journal-title":"Physiol Rev"},{"key":"5_CR18","doi-asserted-by":"publisher","first-page":"G910","DOI":"10.1152\/ajpgi.90672.2008","volume":"296","author":"R Govindarajan","year":"2009","unstructured":"Govindarajan R, Leung GP, Zhou M, Tse CM, Wang J, Unadkat JD (2009) Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol 296:G910\u2013G922","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5_CR19","doi-asserted-by":"crossref","unstructured":"Holmes AP, Ray CJ, Pearson SA, Coney AM, Kumar P (2017) Ecto-5\u2032-nucleotidase (CD73) regulates peripheral chemoreceptor activity and cardiorespiratory responses to hypoxia. J Physiol","DOI":"10.1113\/JP274498"},{"key":"5_CR20","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1046\/j.1471-4159.2000.740621.x","volume":"74","author":"S Kobayashi","year":"2000","unstructured":"Kobayashi S, Zimmermann H, Millhorn DE (2000) Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. J Neurochem 74:621\u2013632","journal-title":"J Neurochem"},{"key":"5_CR21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cphy.c100069","volume":"2","author":"P Kumar","year":"2012","unstructured":"Kumar P, Prabhakar NR (2012) Peripheral chemoreceptors: function and plasticity of the carotid body. Compr Physiol 2:141\u2013219","journal-title":"Compr Physiol"},{"key":"5_CR22","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1183\/09031936.00056408","volume":"32","author":"J Lopez-Barneo","year":"2008","unstructured":"Lopez-Barneo J, Ortega-Saenz P, Pardal R, Pascual A, Piruat JI (2008) Carotid body oxygen sensing. Eur Respir J 32:1386\u20131398","journal-title":"Eur Respir J"},{"key":"5_CR23","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1113\/JP271494","volume":"594","author":"S Murali","year":"2016","unstructured":"Murali S, Nurse CA (2016) Purinergic signalling mediates bidirectional crosstalk between chemoreceptor type I and glial-like type II cells of the rat carotid body. J Physiol 594:391\u2013406","journal-title":"J Physiol"},{"key":"5_CR24","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1113\/expphysiol.2009.049312","volume":"95","author":"CA Nurse","year":"2010","unstructured":"Nurse CA (2010) Neurotransmitter and neuromodulatory mechanisms at peripheral arterial chemoreceptors. Exp Physiol 95:657\u2013667","journal-title":"Exp Physiol"},{"key":"5_CR25","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1113\/jphysiol.2013.269829","volume":"592","author":"CA Nurse","year":"2014","unstructured":"Nurse CA (2014) Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors. J Physiol 592:3419\u20133426","journal-title":"J Physiol"},{"key":"5_CR26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.semcdb.2012.09.006","volume":"24","author":"CA Nurse","year":"2013","unstructured":"Nurse CA, Piskuric NA (2013) Signal processing at mammalian carotid body chemoreceptors. Semin Cell Dev Biol 24:22\u201330","journal-title":"Semin Cell Dev Biol"},{"key":"5_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00238411","volume":"144","author":"C Peers","year":"1995","unstructured":"Peers C, Buckler KJ (1995) Transduction of chemostimuli by the type I carotid body cell. J Membr Biol 144:1\u20139","journal-title":"J Membr Biol"},{"key":"5_CR28","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1111\/j.1471-4159.1991.tb06414.x","volume":"57","author":"MT Perez-Garcia","year":"1991","unstructured":"Perez-Garcia MT, Almaraz L, Gonzalez C (1991) Cyclic AMP modulates differentially the release of dopamine induced by hypoxia and other stimuli and increases dopamine synthesis in the rabbit carotid body. J Neurochem 57:1992\u20132000","journal-title":"J Neurochem"},{"key":"5_CR29","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.resp.2007.01.009","volume":"157","author":"FL Powell","year":"2007","unstructured":"Powell FL (2007) The influence of chronic hypoxia upon chemoreception. Respir Physiol Neurobiol 157:154\u2013161","journal-title":"Respir Physiol Neurobiol"},{"key":"5_CR30","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1113\/jphysiol.2001.012836","volume":"537","author":"M Prasad","year":"2001","unstructured":"Prasad M, Fearon IM, Zhang M, Laing M, Vollmer C, Nurse CA (2001) Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling. J Physiol 537:667\u2013677","journal-title":"J Physiol"},{"key":"5_CR31","doi-asserted-by":"publisher","first-page":"11315","DOI":"10.1523\/JNEUROSCI.23-36-11315.2003","volume":"23","author":"W Rong","year":"2003","unstructured":"Rong W, Gourine AV, Cockayne DA, Xiang Z, Ford AP et al (2003) Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci 23:11315\u201311321","journal-title":"J Neurosci"},{"key":"5_CR32","doi-asserted-by":"publisher","first-page":"C274","DOI":"10.1152\/ajpcell.00328.2016","volume":"313","author":"S Salman","year":"2017","unstructured":"Salman S, Vollmer C, McClelland GB, Nurse CA (2017) Characterization of ectonucleotidase expression in the rat carotid body: regulation by chronic hypoxia. Am J Physiol Cell Physiol 313:C274\u2013CC84","journal-title":"Am J Physiol Cell Physiol"},{"key":"5_CR33","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1139\/y2012-054","volume":"90","author":"A Tse","year":"2012","unstructured":"Tse A, Yan L, Lee AK, Tse FW (2012) Autocrine and paracrine actions of ATP in rat carotid body. Can J Physiol Pharmacol 90:705\u2013711","journal-title":"Can J Physiol Pharmacol"},{"key":"5_CR34","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1113\/jphysiol.2003.039735","volume":"549","author":"J Xu","year":"2003","unstructured":"Xu J, Tse FW, Tse A (2003) ATP triggers intracellular Ca2+ release in type II cells of the rat carotid body. J Physiol 549:739\u2013747","journal-title":"J Physiol"},{"issue":"Pt 1","key":"5_CR35","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1469-7793.2000.t01-1-00143.x","volume":"525","author":"M Zhang","year":"2000","unstructured":"Zhang M, Zhong H, Vollmer C, Nurse CA (2000) Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors. J Physiol 525(Pt 1):143\u2013158","journal-title":"J Physiol"},{"key":"5_CR36","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.1113\/jphysiol.2012.236265","volume":"590","author":"M Zhang","year":"2012","unstructured":"Zhang M, Piskuric NA, Vollmer C, Nurse CA (2012) P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP. J Physiol 590:4335\u20134350","journal-title":"J Physiol"}],"container-title":["Advances in Experimental Medicine and Biology","Arterial Chemoreceptors"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-91137-3_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T15:06:39Z","timestamp":1662303999000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-91137-3_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319911366","9783319911373"],"references-count":36,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-91137-3_5","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}