{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T13:14:35Z","timestamp":1743081275147,"version":"3.40.3"},"publisher-location":"Cham","reference-count":13,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319959320"},{"type":"electronic","value":"9783319959337"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-319-95933-7_45","type":"book-chapter","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T06:48:38Z","timestamp":1530773318000},"page":"371-382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["TNSim: A Tumor Sequencing Data Simulator for Incorporating Clonality Information"],"prefix":"10.1007","author":[{"given":"Yu","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongmeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhe","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"issue":"7471","key":"45_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature12634","volume":"502","author":"C Kandoth","year":"2013","unstructured":"Kandoth, C., McLellan, M., Vandin, F., et al.: Mutational landscape and significance across 12 major cancer types. Nature 502(7471), 333\u2013339 (2013)","journal-title":"Nature"},{"key":"45_CR2","doi-asserted-by":"publisher","first-page":"10086","DOI":"10.1038\/ncomms10086","volume":"6","author":"C Lu","year":"2015","unstructured":"Lu, C., Xie, M., Wendl, M., et al.: Patterns and functional implications of rare germline variants across 12 cancer types. Nature Commun. 6, 10086 (2015)","journal-title":"Nature Commun."},{"issue":"2","key":"45_CR3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cell.2018.03.039","volume":"173","author":"K Huang","year":"2018","unstructured":"Huang, K., Mashl, R., Wu, Y., et al.: Pathogenic germline variants in 10,389 adult cancers. Cell 173(2), 355\u2013370 (2018)","journal-title":"Cell"},{"issue":"2","key":"45_CR4","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.canlet.2012.12.028","volume":"340","author":"L Ding","year":"2013","unstructured":"Ding, L., Raphael, B., Chen, F., et al.: Advances for studying clonal evolution in cancer. Cancer Lett. 340(2), 212\u2013219 (2013)","journal-title":"Cancer Lett."},{"issue":"1","key":"45_CR5","first-page":"118","volume":"19","author":"The Computational Pan-Genomics Consortium","year":"2018","unstructured":"The Computational Pan-Genomics Consortium: Computational pan-genomics: status, promises and challenges. Briefings Bioinform. 19(1), 118\u2013135 (2018)","journal-title":"Briefings Bioinform."},{"issue":"26C","key":"45_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.gde.2014.04.002","volume":"26","author":"J Vijg","year":"2014","unstructured":"Vijg, J.: Somatic mutations, genome mosaicism, cancer and aging. Curr. Opin. Genet. Dev. 26(26C), 141\u2013149 (2014)","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"12","key":"45_CR7","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/nm.3733","volume":"20","author":"M Xie","year":"2014","unstructured":"Xie, M., Lu, C., Wang, J., et al.: Age-related cancer mutations associated with clonal hematopoietic expansion. Nature Med. 20(12), 1472\u20131478 (2014)","journal-title":"Nature Med."},{"key":"45_CR8","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/978-3-319-63312-1_25","volume-title":"Intelligent Computing Theories and Application","author":"Yu Geng","year":"2017","unstructured":"Geng, Yu., Zhao, Z., Liu, R., Zheng, T., Xu, J., Huang, Y., Zhang, X., Xiao, X., Wang, J.: Accurately estimating tumor purity of samples with high degree of heterogeneity from cancer sequencing data. In: Huang, D.-S., Jo, K.-H., Figueroa-Garc\u00eda, J.C. (eds.) ICIC 2017. LNCS, vol. 10362, pp. 273\u2013285. Springer, Cham (2017). https:\/\/doi.org\/10.1007\/978-3-319-63312-1_25"},{"issue":"11","key":"45_CR9","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1093\/bioinformatics\/bts187","volume":"28","author":"X Hu","year":"2012","unstructured":"Hu, X., Yuan, J., Shi, Y., et al.: pIRS: Profile-based Illumina pair-end reads simulator. Bioinformatics 28(11), 1533\u20131535 (2012)","journal-title":"Bioinformatics"},{"issue":"4","key":"45_CR10","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1093\/bioinformatics\/btr708","volume":"28","author":"W Huang","year":"2012","unstructured":"Huang, W., Li, L., Myers, J., et al.: ART: a next-generation sequencing read simulator. Bioinformatics 28(4), 593\u2013594 (2012)","journal-title":"Bioinformatics"},{"issue":"74","key":"45_CR11","first-page":"1","volume":"13","author":"K McElroy","year":"2012","unstructured":"McElroy, K., Luciani, F., Thomas, T.: GemSIM: general, error-model based simulator of next-generation sequencing data. BMC Genom. 13(74), 1\u20139 (2012)","journal-title":"BMC Genom."},{"key":"45_CR12","series-title":"LNCS","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/978-3-319-63312-1_26","volume-title":"ICIC 2017","author":"Y Geng","year":"2017","unstructured":"Geng, Y., Zhao, Z., Xu, J., et al.: Identifying heterogeneity patterns of allelic imbalance on germline variants to infer clonal architecture. In: Huang, D., Jo, K., Figueroa-Garc\u00eda, J. (eds.) ICIC 2017. LNCS, vol. 10362, pp. 286\u2013297. Springer, Cham (2017). https:\/\/doi.org\/10.1007\/978-3-319-63312-1_26"},{"issue":"8","key":"45_CR13","doi-asserted-by":"publisher","first-page":"e1003665","DOI":"10.1371\/journal.pcbi.1003665","volume":"10","author":"C Miller","year":"2014","unstructured":"Miller, C., White, B., Dees, N., et al.: SciClone: Inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution. PLoS Comput. Biol. 10(8), e1003665 (2014)","journal-title":"PLoS Comput. Biol."}],"container-title":["Lecture Notes in Computer Science","Intelligent Computing Theories and Application"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-95933-7_45","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T16:00:25Z","timestamp":1709827225000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-319-95933-7_45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783319959320","9783319959337"],"references-count":13,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-95933-7_45","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"6 July 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"ICIC","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Intelligent Computing","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Wuhan","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"China","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2018","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"15 August 2018","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"18 August 2018","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"14","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"icic2018","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/ic-ic.tongji.edu.cn\/2018\/index.htm","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Single-blind","order":1,"name":"type","label":"Type","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"LOD","order":2,"name":"conference_management_system","label":"Conference Management System","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"632","order":3,"name":"number_of_submissions_sent_for_review","label":"Number of Submissions Sent for Review","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"275","order":4,"name":"number_of_full_papers_accepted","label":"Number of Full Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"72","order":5,"name":"number_of_short_papers_accepted","label":"Number of Short Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"44% - The value is computed by the equation \"Number of Full Papers Accepted \/ Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","order":6,"name":"acceptance_rate_of_full_papers","label":"Acceptance Rate of Full Papers","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"3.46","order":7,"name":"average_number_of_reviews_per_paper","label":"Average Number of Reviews per Paper","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"0","order":8,"name":"average_number_of_papers_per_reviewer","label":"Average Number of Papers per Reviewer","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"Yes","order":9,"name":"external_reviewers_involved","label":"External Reviewers Involved","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}}]}}