{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:36:41Z","timestamp":1793036201342,"version":"4.5.0"},"publisher-location":"Cham","reference-count":102,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319997155","type":"print"},{"value":"9783319997162","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-319-99716-2_5","type":"book-chapter","created":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T16:33:57Z","timestamp":1546187637000},"page":"99-126","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Angioimmunoblastic T-Cell Lymphoma"],"prefix":"10.1007","author":[{"given":"Mariko","family":"Yabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Moskowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"5_CR1","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S0140-6736(74)90553-4","volume":"1","author":"G Frizzera","year":"1974","unstructured":"Frizzera G, Moran EM, Rappaport H (1974) Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet 1:1070\u20131073","journal-title":"Lancet"},{"key":"5_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197501022920101","volume":"292","author":"RJ Lukes","year":"1975","unstructured":"Lukes RJ, Tindle BH (1975) Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin\u2019s disease. New Engl J Med 292:1\u20138","journal-title":"New Engl J Med"},{"key":"5_CR3","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1055\/s-0028-1103872","volume":"104","author":"K Lennert","year":"1979","unstructured":"Lennert K (1979) Nature, prognosis and nomenclature of angioimmunoblastic (lymphadenopathy (lymphogranulomatosis X or T-zone lymphoma). Deutsche medizinische Wochenschrift 104:1246\u20131247","journal-title":"Deutsche medizinische Wochenschrift"},{"key":"5_CR4","first-page":"549","volume":"133","author":"AC Feller","year":"1988","unstructured":"Feller AC, Griesser H, Schilling CV, Wacker HH, Dallenbach F, Bartels H, Kuse R, Mak TW, Lennert K (1988) Clonal gene rearrangement patterns correlate with immunophenotype and clinical parameters in patients with angioimmunoblastic lymphadenopathy. Am J Pathol 133:549\u2013556","journal-title":"Am J Pathol"},{"key":"5_CR5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/blood.V72.2.413.413","volume":"72","author":"Y Kaneko","year":"1988","unstructured":"Kaneko Y, Maseki N, Sakurai M, Takayama S, Nanba K, Kikuchi M, Frizzera G (1988) Characteristic karyotypic pattern in T-cell lymphoproliferative disorders with reactive \u201cangioimmunoblastic lymphadenopathy with dysproteinemia-type\u201d features. Blood 72:413\u2013421","journal-title":"Blood"},{"key":"5_CR6","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","volume":"84","author":"NL Harris","year":"1994","unstructured":"Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC et al (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the international Lymphoma study group. Blood 84:1361\u20131392","journal-title":"Blood"},{"issue":"Suppl 1","key":"5_CR7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/annonc\/11.suppl_1.S3","volume":"11","author":"NL Harris","year":"2000","unstructured":"Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J (2000) Lymphoma classification\u2014from controversy to consensus: the R.E.A.L. and WHO classification of lymphoid neoplasms. Ann Oncol 11(Suppl 1):3\u201310","journal-title":"Ann Oncol"},{"key":"5_CR8","doi-asserted-by":"crossref","unstructured":"Vose J, Armitage J, Weisenburger D (2008) International TCLP. International peripheral T-cell and natural killer\/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 26:4124\u20134130","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"5_CR9","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1182\/blood-2007-08-105759","volume":"111","author":"N Mourad","year":"2008","unstructured":"Mourad N, Mounier N, Briere J, Raffoux E, Delmer A, Feller A, Meijer CJ, Emile JF, Bouabdallah R, Bosly A, Diebold J, Haioun C, Coiffier B, Gisselbrecht C, Gaulard P (2008) Groupe d\u2019Etude des Lymphomes de lA. Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d\u2019Etude des Lymphomes de l\u2019Adulte (GELA) trials. Blood 111:4463\u20134470","journal-title":"Blood"},{"key":"5_CR10","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1309\/AJCPQXKCHQH4VAJ5","volume":"131","author":"YU Cho","year":"2009","unstructured":"Cho YU, Chi HS, Park CJ, Jang S, Seo EJ, Huh J (2009) Distinct features of angioimmunoblastic T-cell lymphoma with bone marrow involvement. Am J Clin Pathol 131:640\u2013646","journal-title":"Am J Clin Pathol"},{"key":"5_CR11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2141.2009.08003.x","volume":"148","author":"L Leval de","year":"2010","unstructured":"de Leval L, Gisselbrecht C, Gaulard P (2010) Advances in the understanding and management of angioimmunoblastic T-cell lymphoma. Br J Haematol 148:673\u2013689","journal-title":"Br J Haematol"},{"key":"5_CR12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/hon.2080","volume":"32","author":"A Singh","year":"2014","unstructured":"Singh A, Schabath R, Ratei R, Stroux A, Klemke CD, Nebe T, Florcken A, van Lessen A, Anagnostopoulos I, Dorken B, Ludwig WD, Pezzutto A, Westermann J (2014) Peripheral blood sCD3(\u2212) CD4(+) T cells: a useful diagnostic tool in angioimmunoblastic T cell lymphoma. Hematol Oncol 32:16\u201321","journal-title":"Hematol Oncol"},{"key":"5_CR13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2141.2007.06725.x","volume":"138","author":"K Willenbrock","year":"2007","unstructured":"Willenbrock K, Brauninger A, Hansmann ML (2007) Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein-Barr virus-infected cells in early cases. Br J Haematol 138:733\u2013739","journal-title":"Br J Haematol"},{"key":"5_CR14","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1182\/blood-2006-10-055145","volume":"109","author":"L Leval de","year":"2007","unstructured":"de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Briere J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (2007) The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood 109:4952\u20134963","journal-title":"Blood"},{"key":"5_CR15","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1182\/blood-2005-03-1083","volume":"106","author":"KL Grogg","year":"2005","unstructured":"Grogg KL, Attygalle AD, Macon WR, Remstein ED, Kurtin PJ, Dogan A (2005) Angioimmunoblastic T-cell lymphoma: a neoplasm of germinal-center T-helper cells? Blood 106:1501\u20131502","journal-title":"Blood"},{"key":"5_CR16","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.192.11.1545","volume":"192","author":"D Breitfeld","year":"2000","unstructured":"Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Forster R (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192:1545\u20131552","journal-title":"J Exp Med"},{"key":"5_CR17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/MOH.0000000000000261","volume":"23","author":"JR Cortes","year":"2016","unstructured":"Cortes JR, Palomero T (2016) The curious origins of angioimmunoblastic T-cell lymphoma. Curr Opin Hematol 23:434\u2013443","journal-title":"Curr Opin Hematol"},{"key":"5_CR18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/ni.3054","volume":"16","author":"H Ueno","year":"2015","unstructured":"Ueno H, Banchereau J, Vinuesa CG (2015) Pathophysiology of T follicular helper cells in humans and mice. Nat Immunol 16:142\u2013152","journal-title":"Nat Immunol"},{"key":"5_CR19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","volume":"34","author":"CG Vinuesa","year":"2016","unstructured":"Vinuesa CG, Linterman MA, Yu D, MacLennan IC (2016) Follicular helper T cells. Annu Rev Immunol 34:335\u2013368","journal-title":"Annu Rev Immunol"},{"key":"5_CR20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ni.3050","volume":"16","author":"JW Leavenworth","year":"2015","unstructured":"Leavenworth JW, Verbinnen B, Yin J, Huang H, Cantor H (2015) A p85alpha-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells. Nat Immunol 16:96\u2013106","journal-title":"Nat Immunol"},{"key":"5_CR21","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","volume":"325","author":"RI Nurieva","year":"2009","unstructured":"Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH, Dong C (2009) Bcl6 mediates the development of T follicular helper cells. Science 325:1001\u20131005","journal-title":"Science"},{"key":"5_CR22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1056\/NEJMc1111708","volume":"366","author":"L Couronne","year":"2012","unstructured":"Couronne L, Bastard C, Bernard OA (2012) TET2 and DNMT3A mutations in human T-cell lymphoma. New Engl J Med 366:95\u201396","journal-title":"New Engl J Med"},{"key":"5_CR23","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1182\/blood-2013-10-531509","volume":"123","author":"O Odejide","year":"2014","unstructured":"Odejide O, Weigert O, Lane AA, Toscano D, Lunning MA, Kopp N, Kim S, van Bodegom D, Bolla S, Schatz JH, Teruya-Feldstein J, Hochberg E, Louissaint A, Dorfman D, Stevenson K, Rodig SJ, Piccaluga PP, Jacobsen E, Pileri SA, Harris NL, Ferrero S, Inghirami G, Horwitz SM, Weinstock DM (2014) A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. Blood 123:1293\u20131296","journal-title":"Blood"},{"key":"5_CR24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ng.2872","volume":"46","author":"M Sakata-Yanagimoto","year":"2014","unstructured":"Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y, Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K, Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K, Ogawa S, Chiba S (2014) Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet 46:171\u2013175","journal-title":"Nat Genet"},{"key":"5_CR25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ng.2873","volume":"46","author":"T Palomero","year":"2014","unstructured":"Palomero T, Couronne L, Khiabanian H, Kim MY, Ambesi-Impiombato A, Perez-Garcia A, Carpenter Z, Abate F, Allegretta M, Haydu JE, Jiang X, Lossos IS, Nicolas C, Balbin M, Bastard C, Bhagat G, Piris MA, Campo E, Bernard OA, Rabadan R, Ferrando AA (2014) Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet 46:166\u2013170","journal-title":"Nat Genet"},{"key":"5_CR26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.cellbio.21.020604.150721","volume":"21","author":"AB Jaffe","year":"2005","unstructured":"Jaffe AB, Hall A (2005) Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21:247\u2013269","journal-title":"Annu Rev Cell Dev Biol"},{"key":"5_CR27","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1093\/emboj\/16.9.2397","volume":"16","author":"SW Henning","year":"1997","unstructured":"Henning SW, Galandrini R, Hall A, Cantrell DA (1997) The GTPase Rho has a critical regulatory role in thymus development. EMBO J 16:2397\u20132407","journal-title":"EMBO J"},{"key":"5_CR28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.autrev.2008.07.044","volume":"8","author":"AB Pernis","year":"2009","unstructured":"Pernis AB (2009) Rho GTPase-mediated pathways in mature CD4+\u2009T cells. Autoimmun Rev 8:199\u2013203","journal-title":"Autoimmun Rev"},{"key":"5_CR29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ng.2916","volume":"46","author":"HY Yoo","year":"2014","unstructured":"Yoo HY, Sung MK, Lee SH, Kim S, Lee H, Park S, Kim SC, Lee B, Rho K, Lee JE, Cho KH, Kim W, Ju H, Kim J, Kim SJ, Kim WS, Lee S, Ko YH (2014) A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nat Genet 46:371\u2013375","journal-title":"Nat Genet"},{"key":"5_CR30","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1182\/blood-2015-06-644948","volume":"127","author":"Y Nagata","year":"2016","unstructured":"Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, Suzuki H, Kon A, Yoshida K, Sato Y, Sato-Otsubo A, Sanada M, Munakata W, Nakamura H, Hama N, Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S (2016) Variegated RHOA mutations in adult T-cell leukemia\/lymphoma. Blood 127:596\u2013604","journal-title":"Blood"},{"key":"5_CR31","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (2016) The 2016 revision of the world health organization classification of lymphoid neoplasms. Blood 127:2375\u20132390","journal-title":"Blood"},{"key":"5_CR32","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1182\/blood-2011-11-391748","volume":"119","author":"RA Cairns","year":"2012","unstructured":"Cairns RA, Iqbal J, Lemonnier F, Kucuk C, de Leval L, Jais JP, Parrens M, Martin A, Xerri L, Brousset P, Chan LC, Chan WC, Gaulard P, Mak TW (2012) IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood 119:1901\u20131903","journal-title":"Blood"},{"key":"5_CR33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature09586","volume":"468","author":"M Ko","year":"2010","unstructured":"Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, An J, Lamperti ED, Koh KP, Ganetzky R, Liu XS, Aravind L, Agarwal S, Maciejewski JP, Rao A (2010) Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468:839\u2013843","journal-title":"Nature"},{"key":"5_CR34","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1182\/blood-2009-03-210039","volume":"114","author":"O Abdel-Wahab","year":"2009","unstructured":"Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, Malinge S, Yao J, Kilpivaara O, Bhat R, Huberman K, Thomas S, Dolgalev I, Heguy A, Paietta E, Le Beau MM, Beran M, Tallman MS, Ebert BL, Kantarjian HM, Stone RM, Gilliland DG, Crispino JD, Levine RL (2009) Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 114:144\u2013147","journal-title":"Blood"},{"key":"5_CR35","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1182\/blood-2015-05-644591","volume":"126","author":"C Wang","year":"2015","unstructured":"Wang C, McKeithan TW, Gong Q, Zhang W, Bouska A, Rosenwald A, Gascoyne RD, Wu X, Wang J, Muhammad Z, Jiang B, Rohr J, Cannon A, Steidl C, Fu K, Li Y, Hung S, Weisenburger DD, Greiner TC, Smith L, Ott G, Rogan EG, Staudt LM, Vose J, Iqbal J, Chan WC (2015) IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma. Blood 126:1741\u20131752","journal-title":"Blood"},{"key":"5_CR36","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.1038\/bcj.2014.83","volume":"4","author":"H Muto","year":"2014","unstructured":"Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchida K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S (2014) Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice. Blood Cancer J 4:e264","journal-title":"Blood Cancer J"},{"key":"5_CR37","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1074\/jbc.M112.435495","volume":"288","author":"PS Ward","year":"2013","unstructured":"Ward PS, Lu C, Cross JR, Abdel-Wahab O, Levine RL, Schwartz GK, Thompson CB (2013) The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization. J Biol Chem 288:3804\u20133815","journal-title":"J Biol Chem"},{"key":"5_CR38","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1200\/JCO.2010.28.3762","volume":"28","author":"P Paschka","year":"2010","unstructured":"Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Kronke J, Bullinger L, Spath D, Kayser S, Zucknick M, Gotze K, Horst HA, Germing U, Dohner H, Dohner K (2010) IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol Official J Am Soc Clin Oncol 28:3636\u20133643","journal-title":"J Clin Oncol Official J Am Soc Clin Oncol"},{"key":"5_CR39","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1038\/leu.2016.29","volume":"30","author":"L Scourzic","year":"2016","unstructured":"Scourzic L, Couronne L, Pedersen MT, Della Valle V, Diop M, Mylonas E, Calvo J, Mouly E, Lopez CK, Martin N, Fontenay M, Bender A, Guibert S, Dubreuil P, Dessen P, Droin N, Pflumio F, Weber M, Gaulard P, Helin K, Mercher T, Bernard OA (2016) DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice. Leukemia 30:1388\u20131398","journal-title":"Leukemia"},{"key":"5_CR40","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/leu.2015.357","volume":"30","author":"J Rohr","year":"2016","unstructured":"Rohr J, Guo S, Huo J, Bouska A, Lachel C, Li Y, Simone PD, Zhang W, Gong Q, Wang C, Cannon A, Heavican T, Mottok A, Hung S, Rosenwald A, Gascoyne R, Fu K, Greiner TC, Weisenburger DD, Vose JM, Staudt LM, Xiao W, Borgstahl GE, Davis S, Steidl C, McKeithan T, Iqbal J, Chan WC (2016) Recurrent activating mutations of CD28 in peripheral T-cell lymphomas. Leukemia 30:1062\u20131070","journal-title":"Leukemia"},{"key":"5_CR41","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2016-02-698977","volume":"128","author":"D Vallois","year":"2016","unstructured":"Vallois D, Dobay MP, Morin RD, Lemonnier F, Missiaglia E, Juilland M, Iwaszkiewicz J, Fataccioli V, Bisig B, Roberti A, Grewal J, Bruneau J, Fabiani B, Martin A, Bonnet C, Michielin O, Jais JP, Figeac M, Bernard OA, Delorenzi M, Haioun C, Tournilhac O, Thome M, Gascoyne RD, Gaulard P, de Leval L (2016) Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas. Blood 128:1490\u20131502","journal-title":"Blood"},{"key":"5_CR42","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3324\/haematol.2015.139253","volume":"101","author":"HY Yoo","year":"2016","unstructured":"Yoo HY, Kim P, Kim WS, Lee SH, Kim S, Kang SY, Jang HY, Lee JE, Kim J, Kim SJ, Ko YH, Lee S (2016) Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma. Haematologica 101:757\u2013763","journal-title":"Haematologica"},{"key":"5_CR43","doi-asserted-by":"crossref","first-page":"7990","DOI":"10.1038\/sj.onc.1208074","volume":"23","author":"EH Palacios","year":"2004","unstructured":"Palacios EH, Weiss A (2004) Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 23:7990\u20138000","journal-title":"Oncogene"},{"key":"5_CR44","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1097\/PAS.0b013e3182991415","volume":"37","author":"AD Attygalle","year":"2013","unstructured":"Attygalle AD, Feldman AL, Dogan A (2013) ITK\/SYK translocation in angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 37:1456\u20131457","journal-title":"Am J Surg Pathol"},{"key":"5_CR45","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1182\/blood-2013-05-504308","volume":"123","author":"JP Vaque","year":"2014","unstructured":"Vaque JP, Gomez-Lopez G, Monsalvez V, Varela I, Martinez N, Perez C, Dominguez O, Grana O, Rodriguez-Peralto JL, Rodriguez-Pinilla SM, Gonzalez-Vela C, Rubio-Camarillo M, Martin-Sanchez E, Pisano DG, Papadavid E, Papadaki T, Requena L, Garcia-Marco JA, Mendez M, Provencio M, Hospital M, Suarez-Massa D, Postigo C, San Segundo D, Lopez-Hoyos M, Ortiz-Romero PL, Piris MA, Sanchez-Beato M (2014) PLCG1 mutations in cutaneous T-cell lymphomas. Blood 123:2034\u20132043","journal-title":"Blood"},{"key":"5_CR46","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ng.3016","volume":"46","author":"I Petrini","year":"2014","unstructured":"Petrini I, Meltzer PS, Kim IK, Lucchi M, Park KS, Fontanini G, Gao J, Zucali PA, Calabrese F, Favaretto A, Rea F, Rodriguez-Canales J, Walker RL, Pineda M, Zhu YJ, Lau C, Killian KJ, Bilke S, Voeller D, Dakshanamurthy S, Wang Y, Giaccone G (2014) A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors. Nat Genet 46:844\u2013849","journal-title":"Nat Genet"},{"key":"5_CR47","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1158\/0008-5472.CAN-07-1708","volume":"67","author":"PP Piccaluga","year":"2007","unstructured":"Piccaluga PP, Agostinelli C, Califano A, Carbone A, Fantoni L, Ferrari S, Gazzola A, Gloghini A, Righi S, Rossi M, Tagliafico E, Zinzani PL, Zupo S, Baccarani M, Pileri SA (2007) Gene expression analysis of angioimmunoblastic lymphoma indicates derivation from T follicular helper cells and vascular endothelial growth factor deregulation. Can Res 67:10703\u201310710","journal-title":"Can Res"},{"key":"5_CR48","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/labinvest.3700145","volume":"84","author":"WL Zhao","year":"2004","unstructured":"Zhao WL, Mourah S, Mounier N, Leboeuf C, Daneshpouy ME, Legres L, Meignin V, Oksenhendler E, Maignin CL, Calvo F, Briere J, Gisselbrecht C, Janin A (2004) Vascular endothelial growth factor-A is expressed both on lymphoma cells and endothelial cells in angioimmunoblastic T-cell lymphoma and related to lymphoma progression. Lab Invest J Tech Methods Pathol 84:1512\u20131519","journal-title":"Lab Invest J Tech Methods Pathol"},{"key":"5_CR49","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1365-2141.2008.07534.x","volume":"144","author":"K Konstantinou","year":"2009","unstructured":"Konstantinou K, Yamamoto K, Ishibashi F, Mizoguchi Y, Kurata M, Nakagawa Y, Suzuki K, Sawabe M, Ohta M, Miyakoshi S, Crawley JT, Kitagawa M (2009) Angiogenic mediators of the angiopoietin system are highly expressed by CD10-positive lymphoma cells in angioimmunoblastic T-cell lymphoma. Br J Haematol 144:696\u2013704","journal-title":"Br J Haematol"},{"issue":"19","key":"5_CR50","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1182\/blood-2013-11-536359","volume":"123","author":"J. Iqbal","year":"2014","unstructured":"Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM (2014) Lymphoma Leukemia molecular profiling P, the international peripheral TcLP. Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma. Blood 123:2915\u20132923","journal-title":"Blood"},{"key":"5_CR51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s002770050182","volume":"72","author":"R Rho","year":"1996","unstructured":"Rho R, Laddis T, McQuain C, Selves J, Woda B, Knecht H (1996) Miliary tuberculosis in a patient with Epstein-Barr virus-associated angioimmunoblastic lymphadenopathy. Ann Hematol 72:333\u2013335","journal-title":"Ann Hematol"},{"key":"5_CR52","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1439-0507.1991.tb00665.x","volume":"34","author":"M Konig","year":"1991","unstructured":"Konig M, Grunder K, Nilles M, Schill WB (1991) Cutaneous cryptococcosis as the first symptom of a disseminated cryptococcosis in a patient with lymphogranulomatosis X. Mycoses 34:309\u2013311","journal-title":"Mycoses"},{"key":"5_CR53","first-page":"265","volume":"81","author":"M Luppi","year":"1996","unstructured":"Luppi M, Torelli G (1996) The new lymphotropic herpesviruses (HHV-6, HHV-7, HHV-8) and hepatitis C virus (HCV) in human lymphoproliferative diseases: an overview. Haematologica 81:265\u2013281","journal-title":"Haematologica"},{"key":"5_CR54","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0190-9622(08)81242-X","volume":"23","author":"TN Helm","year":"1990","unstructured":"Helm TN, Steck WD, Proffitt MR, Bergfeld WF, Tubbs RR, Lo J (1990) Kaposi\u2019s sarcoma, angioimmunoblastic lymphadenopathy, and antibody to HIV-1 p24 antigen in a patient nonreactive for HIV-1 with use of ELISA. J Am Acad Dermatol 23:317\u2013318","journal-title":"J Am Acad Dermatol"},{"key":"5_CR55","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1182\/blood.V80.7.1804.1804","volume":"80","author":"I Anagnostopoulos","year":"1992","unstructured":"Anagnostopoulos I, Hummel M, Finn T, Tiemann M, Korbjuhn P, Dimmler C, Gatter K, Dallenbach F, Parwaresch MR, Stein H (1992) Heterogeneous Epstein-Barr virus infection patterns in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. Blood 80:1804\u20131812","journal-title":"Blood"},{"key":"5_CR56","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1084\/jem.194.7.927","volume":"194","author":"A Brauninger","year":"2001","unstructured":"Brauninger A, Spieker T, Willenbrock K, Gaulard P, Wacker HH, Rajewsky K, Hansmann ML, Kuppers R (2001) Survival and clonal expansion of mutating \u201cforbidden\u201d (immunoglobulin receptor-deficient) epstein-barr virus-infected b cells in angioimmunoblastic t cell lymphoma. J Exp Med 194:927\u2013940","journal-title":"J Exp Med"},{"key":"5_CR57","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2141.2007.06620.x","volume":"138","author":"Y Zhou","year":"2007","unstructured":"Zhou Y, Attygalle AD, Chuang SS, Diss T, Ye H, Liu H, Hamoudi RA, Munson P, Bacon CM, Dogan A, Du MQ (2007) Angioimmunoblastic T-cell lymphoma: histological progression associates with EBV and HHV6B viral load. Br J Haematol 138:44\u201353","journal-title":"Br J Haematol"},{"key":"5_CR58","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1046\/j.1365-2141.2003.04335.x","volume":"121","author":"A Dogan","year":"2003","unstructured":"Dogan A, Attygalle AD, Kyriakou C (2003) Angioimmunoblastic T-cell lymphoma. Br J Haematol 121:681\u2013691","journal-title":"Br J Haematol"},{"key":"5_CR59","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/PAS.0b013e31802d68e9","volume":"31","author":"AD Attygalle","year":"2007","unstructured":"Attygalle AD, Kyriakou C, Dupuis J, Grogg KL, Diss TC, Wotherspoon AC, Chuang SS, Cabecadas J, Isaacson PG, Du MQ, Gaulard P, Dogan A (2007) Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression. Am J Surg Pathol 31:1077\u20131088","journal-title":"Am J Surg Pathol"},{"key":"5_CR60","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1097\/PAS.0b013e3180339f18","volume":"31","author":"O Balague","year":"2007","unstructured":"Balague O, Martinez A, Colomo L, Rosello E, Garcia A, Martinez-Bernal M, Palacin A, Fu K, Weisenburger D, Colomer D, Burke JS, Warnke RA, Campo E (2007) Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features. Am J Surg Pathol 31:1310\u20131322","journal-title":"Am J Surg Pathol"},{"key":"5_CR61","unstructured":"Dogan A, Gaulard P, Jaffe ES, Ralfkiaer E, M\u00fcller-Hermelink HK (2008) Angioimmunoblastic T-cell Lymphoma. In: WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, IARC, pp 309\u2013311"},{"key":"5_CR62","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/PAS.0b013e31820065c9","volume":"35","author":"DM Dorfman","year":"2011","unstructured":"Dorfman DM, Shahsafaei A (2011) CD200 (OX-2 membrane glycoprotein) is expressed by follicular T helper cells and in angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 35:76\u201383","journal-title":"Am J Surg Pathol"},{"key":"5_CR63","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1182\/blood.V99.2.627","volume":"99","author":"A Attygalle","year":"2002","unstructured":"Attygalle A, Al-Jehani R, Diss TC, Munson P, Liu H, Du MQ, Isaacson PG, Dogan A (2002) Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood 99:627\u2013633","journal-title":"Blood"},{"key":"5_CR64","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.3324\/haematol.2013.084913","volume":"98","author":"E Sabattini","year":"2013","unstructured":"Sabattini E, Pizzi M, Tabanelli V, Baldin P, Sacchetti CS, Agostinelli C, Zinzani PL, Pileri SA (2013) CD30 expression in peripheral T-cell lymphomas. Haematologica 98:e81\u20132","journal-title":"Haematologica"},{"key":"5_CR65","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1309\/MC7QRGPTV0LRR98X","volume":"128","author":"A Stacchini","year":"2007","unstructured":"Stacchini A, Demurtas A, Aliberti S, Francia di Celle P, Godio L, Palestro G, Novero D (2007) The usefulness of flow cytometric CD10 detection in the differential diagnosis of peripheral T-cell lymphomas. Am J Clin Pathol 128:854\u2013864","journal-title":"Am J Clin Pathol"},{"key":"5_CR66","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/1097-0320(20000615)42:3<180::AID-CYTO4>3.0.CO;2-0","volume":"42","author":"S Serke","year":"2000","unstructured":"Serke S, van Lessen A, Hummel M, Szczepek A, Huhn D, Stein H (2000) Circulating CD4+\u2009T lymphocytes with intracellular but no surface CD3 antigen in five of seven patients consecutively diagnosed with angioimmunoblastic T-cell lymphoma. Cytometry 42:180\u2013187","journal-title":"Cytometry"},{"key":"5_CR67","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1182\/blood.V84.8.2640.2640","volume":"84","author":"B Schlegelberger","year":"1994","unstructured":"Schlegelberger B, Zhang Y, Weber-Matthiesen K, Grote W (1994) Detection of aberrant clones in nearly all cases of angioimmunoblastic lymphadenopathy with dysproteinemia-type T-cell lymphoma by combined interphase and metaphase cytogenetics. Blood 84:2640\u20132648","journal-title":"Blood"},{"key":"5_CR68","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/gcc.20386","volume":"46","author":"C Thorns","year":"2007","unstructured":"Thorns C, Bastian B, Pinkel D, Roydasgupta R, Fridlyand J, Merz H, Krokowski M, Bernd HW, Feller AC (2007) Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: a matrix-based CGH approach. Genes Chromosom Cancer 46:37\u201344","journal-title":"Genes Chromosom Cancer"},{"key":"5_CR69","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.anndiagpath.2015.03.008","volume":"19","author":"SJ Ruiz","year":"2015","unstructured":"Ruiz SJ, Cotta CV (2015) Follicular helper T-cell lymphoma: a B-cell-rich variant of T-cell lymphoma. Annals Diag Pathol 19:187\u2013192","journal-title":"Annals Diag Pathol"},{"key":"5_CR70","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.humpath.2012.05.002","volume":"43","author":"S Hu","year":"2012","unstructured":"Hu S, Young KH, Konoplev SN, Medeiros LJ (2012) Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas. Hum Pathol 43:1789\u20131798","journal-title":"Hum Pathol"},{"key":"5_CR71","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/PAS.0b013e3181971591","volume":"33","author":"Y Huang","year":"2009","unstructured":"Huang Y, Moreau A, Dupuis J, Streubel B, Petit B, Le Gouill S, Martin-Garcia N, Copie-Bergman C, Gaillard F, Qubaja M, Fabiani B, Roncador G, Haioun C, Delfau-Larue MH, Marafioti T, Chott A, Gaulard P (2009) Peripheral T-cell lymphomas with a follicular growth pattern are derived from follicular helper T cells (TFH) and may show overlapping features with angioimmunoblastic T-cell lymphomas. Am J Surg Pathol 33:682\u2013690","journal-title":"Am J Surg Pathol"},{"key":"5_CR72","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1182\/blood-2013-12-516245","volume":"123","author":"AJ Moskowitz","year":"2014","unstructured":"Moskowitz AJ, Lunning MA, Horwitz SM (2014) How I treat the peripheral T-cell lymphomas. Blood 123:2636\u20132644","journal-title":"Blood"},{"key":"5_CR73","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1200\/JCO.2008.17.4870","volume":"27","author":"P Reimer","year":"2009","unstructured":"Reimer P, Rudiger T, Geissinger E, Weissinger F, Nerl C, Schmitz N, Engert A, Einsele H, Muller-Hermelink HK, Wilhelm M (2009) Autologous stem-cell transplantation as first-line therapy in peripheral T-Cell Lymphomas: results of a prospective multicenter study. J Clin Oncol Official J Am Soc Clin Oncol 27:106\u2013113","journal-title":"J Clin Oncol Official J Am Soc Clin Oncol"},{"issue":"2","key":"5_CR74","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2141.2010.08329.x","volume":"151","author":"Audrey Simon","year":"2010","unstructured":"Simon A, Peoch M, Casassus P, Deconinck E, Colombat P, Desablens B, Tournilhac O, Eghbali H, Foussard C, Jaubert J, Vilque JP, Rossi JF, Lucas V, Delwail V, Thyss A, Maloisel F, Milpied N, le Gouill S, Lamy T, Gressin R. Upfront VIP-reinforced-ABVD (VIP-rABVD) is not superior to CHOP\/21 in newly diagnosed peripheral T cell lymphoma. Results of the randomized phase III trial GOELAMS-LTP95. Br J Haematol 2010;151:159-66","journal-title":"British Journal of Haematology"},{"key":"5_CR75","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1200\/JCO.2008.16.4558","volume":"26","author":"International T-Cell Lymphoma Project","year":"2008","unstructured":"International T-Cell Lymphoma Project (2008) International peripheral T-Cell and natural killer\/T-Cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 26:4124\u20134130","journal-title":"J Clin Oncol"},{"key":"5_CR76","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1093\/annonc\/mdh392","volume":"15","author":"KJ Savage","year":"2004","unstructured":"Savage KJ, Chhanabhai M, Gascoyne RD, Connors JM (2004) Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification. Ann Oncol 15:1467\u20131475","journal-title":"Ann Oncol"},{"key":"5_CR77","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1182\/blood-2010-02-270785","volume":"116","author":"N Schmitz","year":"2010","unstructured":"Schmitz N, Trumper L, Ziepert M, Nickelsen M, Ho AD, Metzner B, Peter N, Loeffler M, Rosenwald A, Pfreundschuh M (2010) Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma study group. Blood 116:3418\u20133425","journal-title":"Blood"},{"key":"5_CR78","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2014-04-573089","volume":"124","author":"F Ellin","year":"2014","unstructured":"Ellin F, Landstrom J, Jerkeman M, Relander T (2014) Real-world data on prognostic factors and treatment in peripheral T-cell lymphomas: a study from the Swedish Lymphoma registry. Blood 124:1570\u20131577","journal-title":"Blood"},{"key":"5_CR79","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1200\/JCO.2011.40.2719","volume":"30","author":"F d\u2019Amore","year":"2012","unstructured":"d\u2019Amore F, Relander T, Lauritzsen GF, Jantunen E, Hagberg H, Anderson H, Holte H, Osterborg A, Merup M, Brown P, Kuittinen O, Erlanson M, Ostenstad B, Fagerli UM, Gadeberg OV, Sundstrom C, Delabie J, Ralfkiaer E, Vornanen M, Toldbod HE (2012) Up-front autologous stem-cell transplantation in peripheral T-cell lymphoma: NLG-T-01. J Clin Oncol Official J Am Soc Clin Oncol 30:3093\u20133099","journal-title":"J Clin Oncol Official J Am Soc Clin Oncol"},{"key":"5_CR80","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.clml.2013.07.005","volume":"13","author":"N Mehta","year":"2013","unstructured":"Mehta N, Maragulia JC, Moskowitz A, Hamlin PA, Lunning MA, Moskowitz CH, Zelenetz A, Matasar MJ, Sauter C, Goldberg J, Horwitz SM (2013) A retrospective analysis of peripheral T-cell lymphoma treated with the intention to transplant in the first remission. Clin Lymphoma Myeloma Leuk 13:664\u2013670","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"5_CR81","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1182\/blood.V128.22.186.186","volume":"128","author":"N Mehta-Shah","year":"2016","unstructured":"Mehta-Shah N, Ito K, Bantilan KS, Moskowitz AJ, Sauter CS, Horwitz SM, Schoder H (2016) Interim PET evaluation by deauville criteria is an effective risk stratification tool in PTCL. Blood 128:186","journal-title":"Blood"},{"key":"5_CR82","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1200\/JCO.2012.48.3883","volume":"31","author":"MA Lunning","year":"2013","unstructured":"Lunning MA, Moskowitz AJ, Horwitz S (2013) Strategies for relapsed peripheral T-cell lymphoma: the tail that wags the curve. J Clin Oncol 31:1922\u20131927","journal-title":"J Clin Oncol"},{"key":"5_CR83","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1200\/JCO.2007.14.1366","volume":"26","author":"S Gouill Le","year":"2008","unstructured":"Le Gouill S, Milpied N, Buzyn A, De Latour RP, Vernant JP, Mohty M, Moles MP, Bouabdallah K, Bulabois CE, Dupuis J, Rio B, Gratecos N, Yakoub-Agha I, Attal M, Tournilhac O, Decaudin D, Bourhis JH, Blaise D, Volteau C, Michallet M (2008) Societe Francaise de Greffe de Moelle et de Therapie C. Graft-versus-lymphoma effect for aggressive T-cell lymphomas in adults: a study by the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire. J Clin Oncol 26:2264\u20132271","journal-title":"J Clin Oncol"},{"key":"5_CR84","doi-asserted-by":"crossref","unstructured":"Mehta-Shah N, Lunning MA, Ruan J, Nair S, Boruchov AM, Moskowitz AJ, Gerecitano JF, Hamlin PA, Leonard JP, Lynch P, Matasar MJ, Moskowitz C, Portlock C, Younes A, Myskowski P, Nolan P, Palomba ML, Vredenburgh J, Querfeld C, Straus DJ, Zelenetz A, Schroder H, Rademaker J, Schaffer W, Horwitz SM (2015) A phase I\/II trial of the combination of romidepsin and lenalidomide in patients with relapsed\/refractory lymphoma and myeloma. Hematol Oncol 33 (Supplement 1)","DOI":"10.1200\/jco.2015.33.15_suppl.8521"},{"key":"5_CR85","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/annonc\/mdq698","volume":"22","author":"ED Jacobsen","year":"2011","unstructured":"Jacobsen ED, Kim HT, Ho VT, Cutler CS, Koreth J, Fisher DC, Armand P, Alyea EP, Freedman AS, Soiffer RJ, Antin JH (2011) A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides\/Sezary syndrome. Ann Oncol 22:1608\u20131613","journal-title":"Ann Oncol"},{"key":"5_CR86","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.bmt.1705712","volume":"40","author":"SD Smith","year":"2007","unstructured":"Smith SD, Bolwell BJ, Rybicki LA, Brown S, Dean R, Kalaycio M, Sobecks R, Andresen S, Hsi ED, Pohlman B, Sweetenham JW (2007) Autologous hematopoietic stem cell transplantation in peripheral T-cell lymphoma using a uniform high-dose regimen. Bone Marrow Transp 40:239\u2013243","journal-title":"Bone Marrow Transp"},{"key":"5_CR87","doi-asserted-by":"crossref","unstructured":"Horwitz SMC, Kewalramani T, Hamlin P, Straus D, O\u2019Connor O, Noy A, Portlock C, Nimer S, Palomba L, Zelenetz A (2005) Second-line therapy with ICE followed by high dose therapy and autologous stem cell transplantation for relapsed\/refractory peripheral T-cell lymphomas: minimal benefit when analyzed by intent to treat. Blood (ASH Annual Meeting Abstracts) 106, abstract 2679","DOI":"10.1182\/blood.V106.11.2679.2679"},{"key":"5_CR88","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1200\/JCO.2012.46.0188","volume":"31","author":"SM Smith","year":"2013","unstructured":"Smith SM, Burns LJ, van Besien K, Lerademacher J, He W, Fenske TS, Suzuki R, Hsu JW, Schouten HC, Hale GA, Holmberg LA, Sureda A, Freytes CO, Maziarz RT, Inwards DJ, Gale RP, Gross TG, Cairo MS, Costa LJ, Lazarus HM, Wiernik PH, Maharaj D, Laport GG, Montoto S, Hari PN (2013) Hematopoietic cell transplantation for systemic mature T-cell non-hodgkin lymphoma. J Clin Oncol Official J Am Soc Clin Oncol 31:3100\u20133109","journal-title":"J Clin Oncol Official J Am Soc Clin Oncol"},{"key":"5_CR89","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1200\/JCO.2011.37.4223","volume":"30","author":"B Coiffier","year":"2012","unstructured":"Coiffier B, Pro B, Prince HM, Foss F, Sokol L, Greenwood M, Caballero D, Borchmann P, Morschhauser F, Wilhelm M, Pinter-Brown L, Padmanabhan S, Shustov A, Nichols J, Carroll S, Balser J, Balser B, Horwitz S (2012) Results from a pivotal, open-label, phase II study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy. J Clin Oncol 30:631\u2013636","journal-title":"J Clin Oncol"},{"key":"5_CR90","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1200\/JCO.2014.59.2782","volume":"33","author":"OA O\u2019Connor","year":"2015","unstructured":"O\u2019Connor OA, Horwitz S, Masszi T, Van Hoof A, Brown P, Doorduijn J, Hess G, Jurczak W, Knoblauch P, Chawla S, Bhat G, Choi MR, Walewski J, Savage K, Foss F, Allen LF, Shustov A (2015) Belinostat in patients with relapsed or refractory peripheral T-Cell Lymphoma: results of the pivotal phase II BELIEF (CLN-19) study. J Clin Oncol 33:2492\u20132499","journal-title":"J Clin Oncol"},{"key":"5_CR91","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1200\/JCO.2010.29.9024","volume":"29","author":"OA O\u2019Connor","year":"2011","unstructured":"O\u2019Connor OA, Pro B, Pinter-Brown L, Bartlett N, Popplewell L, Coiffier B, Lechowicz MJ, Savage KJ, Shustov AR, Gisselbrecht C, Jacobsen E, Zinzani PL, Furman R, Goy A, Haioun C, Crump M, Zain JM, Hsi E, Boyd A, Horwitz S (2011) Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL study. J Clin Oncol 29:1182\u20131189","journal-title":"J Clin Oncol"},{"key":"5_CR92","first-page":"504","volume":"124","author":"J Dupuis","year":"2014","unstructured":"Dupuis J, Morschhauser F, Ghesquieres H, Tilly H, Casasnovas O, Amorim S, Ribrag V, Coiffier B (2014) Final Analysis of the RO-CHOP Phase Ib\/II Study: romidepsin in association with CHOP in patients with peripheral T-Cell Lymphoma (PTCL). Blood (ASH Annual Meeting Abstracts) 124:504","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"5_CR93","first-page":"2991","volume":"128","author":"N Mehta-Shah","year":"2016","unstructured":"Mehta-Shah N, Moskowitz AJ, Lunning M, Lynch P, Scheuerman M, Kumar A, Gerecitano JF, Zelenetz AD, Hamlin PA, Noy A, Matasar MJ, Palomba ML, Younes A, Schaffer W, Grewal R, Rademaker J, Sauter CS, Dahi PB, Myskowski P, Kheterpal M, Dogan A, Pulitzer M, Tang L, Ni A, Horwitz SM (2016) A phase Ib\/IIa trial of the combination of romidepsin, lenalidomide and carfilzomib in patients with relapsed\/refractory lymphoma shows complete responses in relapsed and refractory T-Cell lymphomas. Blood (ASH Annual Meeting Abstracts) 128:2991","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"5_CR94","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1182\/blood-2013-12-542142","volume":"123","author":"SM Horwitz","year":"2014","unstructured":"Horwitz SM, Advani RH, Bartlett NL, Jacobsen ED, Sharman JP, O\u2019Connor OA, Siddiqi T, Kennedy DA, Oki Y (2014) Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin. Blood 123:3095\u20133100","journal-title":"Blood"},{"key":"5_CR95","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1200\/JCO.2013.54.2456","volume":"32","author":"MA Fanale","year":"2014","unstructured":"Fanale MA, Horwitz SM, Forero-Torres A, Bartlett NL, Advani RH, Pro B, Chen RW, Davies A, Illidge T, Huebner D, Kennedy DA, Shustov AR (2014) Brentuximab vedotin in the front-line treatment of patients with CD30+\u2009peripheral T-cell lymphomas: results of a phase I study. J Clin Oncol 32:3137\u20133143","journal-title":"J Clin Oncol"},{"key":"5_CR96","first-page":"4164","volume":"128","author":"R Delarue","year":"2016","unstructured":"Delarue R, Dupuis J, Sujobert P, Barbieux S, Mar\u00e7ais A, Tournilhac O, Lachenal F, Cheminant M, Sarkozy C, Fataccioli V, Morschhauser F, Hermine O, Haioun C, Gaulard P, Lemonnier F (2016) Treatment with hypomethylating agent 5-Azacytidine induces sustained response in angioimmunoblastic T Cell lymphomas. Blood (ASH Annual Meeting Abstracts) 128:4164","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"issue":"Suppl. 1","key":"5_CR97","first-page":"147","volume":"31","author":"S Horwitz","year":"2013","unstructured":"Horwitz S, O\u2019Connor O, Jurczak W, Van Hoof A, Hess G, Gasztonyi Z, Doorduijn J, Walewski J, Brown P, Vranovsky A, Sissolak G, Aurer I, Nacinovic A, Shustov A, Chawla S, Knoblauch P, Wulf G, Visser O, Zinzani P, Masszi T (2013) Belinostat in relapsed or refractory peripheral T-cell lymphoma subtype angioimmunoblastic T-cell lymphoma: results from the pivotal BELIEF trial. Hematol Oncol 31(Suppl. 1):147","journal-title":"Hematol Oncol"},{"key":"5_CR98","doi-asserted-by":"crossref","unstructured":"Delarue R, Dupuis J, Sujobert P, Barbieux S, Mar\u00e7ais A, Tournilhac O, Lachenal F, Cheminant M, Sarkozy C, Fataccioli V, Morschhauser F, Hermine O, Haioun C, Gaulard P, Lemonnier F (2016) Treatment with hypomethylating agent 5-azacytidine induces sustained response in angioimmunoblastic T cell lymphomas","DOI":"10.1182\/blood.V128.22.4164.4164"},{"key":"5_CR99","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1200\/JCO.2012.43.7285","volume":"31","author":"G Damaj","year":"2013","unstructured":"Damaj G, Gressin R, Bouabdallah K, Cartron G, Choufi B, Gyan E, Banos A, Jaccard A, Park S, Tournilhac O, Schiano-de Collela JM, Voillat L, Joly B, Le Gouill S, Saad A, Cony-Makhoul P, Vilque JP, Sanhes L, Schmidt-Tanguy A, Bubenheim M, Houot R, Diouf M, Marolleau JP, Bene MC, Martin A, Lamy T (2013) Results from a prospective, open-label, phase II trial of bendamustine in refractory or relapsed T-cell lymphomas: the BENTLY trial. J Clin Oncol Official J Am Soc Clin Oncol 31:104\u2013110","journal-title":"J Clin Oncol Official J Am Soc Clin Oncol"},{"key":"5_CR100","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/annonc\/mdp508","volume":"21","author":"PL Zinzani","year":"2010","unstructured":"Zinzani PL, Venturini F, Stefoni V, Fina M, Pellegrini C, Derenzini E, Gandolfi L, Broccoli A, Argnani L, Quirini F, Pileri S, Baccarani M (2010) Gemcitabine as single agent in pretreated T-cell lymphoma patients: evaluation of the long-term outcome. Ann Oncol 21:860\u2013863","journal-title":"Ann Oncol"},{"key":"5_CR101","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1002\/cncr.25377","volume":"116","author":"G Dueck","year":"2010","unstructured":"Dueck G, Chua N, Prasad A, Finch D, Stewart D, White D, van der Jagt R, Johnston J, Belch A, Reiman T (2010) Interim report of a phase 2 clinical trial of lenalidomide for T-cell non-Hodgkin lymphoma. Cancer 116:4541\u20134548","journal-title":"Cancer"},{"key":"5_CR102","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/10428190601137658","volume":"48","author":"R Advani","year":"2007","unstructured":"Advani R, Horwitz S, Zelenetz A, Horning SJ (2007) Angioimmunoblastic T cell lymphoma: treatment experience with cyclosporine. Leukemia Lymp 48:521\u2013525","journal-title":"Leukemia Lymp"}],"container-title":["Cancer Treatment and Research","T-Cell and NK-Cell Lymphomas"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-319-99716-2_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T02:58:07Z","timestamp":1605927487000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-319-99716-2_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,31]]},"ISBN":["9783319997155","9783319997162"],"references-count":102,"URL":"https:\/\/doi.org\/10.1007\/978-3-319-99716-2_5","relation":{},"ISSN":["0927-3042","2509-8497"],"issn-type":[{"value":"0927-3042","type":"print"},{"value":"2509-8497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,31]]}}}