{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T10:22:25Z","timestamp":1770200545328,"version":"3.49.0"},"publisher-location":"Berlin, Heidelberg","reference-count":85,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540689751","type":"print"},{"value":"9783540689768","type":"electronic"}],"license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007]]},"DOI":"10.1007\/978-3-540-68976-8_9","type":"book-chapter","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T20:54:55Z","timestamp":1181163295000},"page":"195-218","source":"Crossref","is-referenced-by-count":76,"title":["Mesenchymal Stem Cells for Cardiac Regenerative Therapy"],"prefix":"10.1007","author":[{"given":"K. H.","family":"Schuleri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Hare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1161\/01.CIR.0000147780.30124.CF","volume":"110","author":"J.D. Abbott","year":"2004","unstructured":"Abbott JD, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ (2004) Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 110:3300\u20133305","journal-title":"Circulation"},{"key":"9_CR2","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1172\/JCI119817","volume":"100","author":"R. Agah","year":"1997","unstructured":"Agah R, Kirshenbaum LA, Abdellatif M, Truong LD, Chakraborty S, Michael LH, Schneider MD (1997) Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest 100:2722\u20132728","journal-title":"J Clin Invest"},{"key":"9_CR3","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","volume":"105","author":"S. Aggarwal","year":"2005","unstructured":"Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815\u20131822","journal-title":"Blood"},{"key":"9_CR4","doi-asserted-by":"publisher","first-page":"11474","DOI":"10.1073\/pnas.0504388102","volume":"102","author":"L.C. Amado","year":"2005","unstructured":"Amado LC, Saliaris AP, Schuleri KH, St JM, Xie JS, Cattaneo S, Dur DJ, and Fitton T, Kuang JQ, Stewart G, Lehrke S, Baumgartner WW, Martin BJ, Heldman AW, Hare JM (2005) Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A 102:11474\u201311479","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9_CR5","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1016\/j.jacc.2006.06.073","volume":"48","author":"L.C. Amado","year":"2006","unstructured":"Amado LC, Schuleri KH, Saliaris AP, Boyle AJ, Helm R, Oskouei B, Centola M, Eneboe V, Young R, Lima JA, Lardo AC, Heldman AW, Hare JM (2006) Multi-modality non-invasive imaging demonstrates in-vivo cardiac regeneration following mesenchymal stem cell therapy. J Am Coll Cardiol 48:2116\u20132124","journal-title":"J Am Coll Cardiol"},{"key":"9_CR6","unstructured":"American Heart Association (2006) Heart Disease and Stroke Statistics\u20142007 Update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee (2006) http:\/\/circ.ahajournals.org\/cgi\/content\/short\/CIRCULATION AHA.106.179918. Circulation. Published online ahead of print, 28 December 2006. Cited 16 January 2007"},{"key":"9_CR7","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/S0735-1097(86)80236-4","volume":"7","author":"P. Anversa","year":"1986","unstructured":"Anversa P, Ricci R, Olivetti G (1986) Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: a review. J Am Coll Cardiol 7:1140\u20131149","journal-title":"J Am Coll Cardiol"},{"key":"9_CR8","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/ana.20501","volume":"57","author":"O.Y. Bang","year":"2005","unstructured":"Bang OY, Lee JS, Lee PH, Lee G (2005) Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57:874\u2013882","journal-title":"Ann Neurol"},{"key":"9_CR9","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1161\/01.CIR.0000084828.50310.6A","volume":"108","author":"I.M. Barbash","year":"2003","unstructured":"Barbash IM, Chouraqui P, Baron J, Feinberg MS, Etzion S, Tessone A, Miller L, Guetta E, Zipori D, Kedes LH, Kloner RA, Leor J (2003) Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 108:863\u2013868","journal-title":"Circulation"},{"key":"9_CR10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S0301-472X(01)00769-X","volume":"30","author":"A. Bartholomew","year":"2002","unstructured":"Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, Hardy W, Devine S, Ucker D, Deans R, Moseley A, Hoffman R (2002) Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30:42\u201348","journal-title":"Exp Hematol"},{"key":"9_CR11","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/197452a0","volume":"197","author":"A.J. Becker","year":"1963","unstructured":"Becker AJ, McCulloch EA, Till JE (1963) Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197:452\u2013454","journal-title":"Nature"},{"key":"9_CR12","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1056\/NEJM200106073442303","volume":"344","author":"A.P. Beltrami","year":"2001","unstructured":"Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R, Nadal-Ginard B, Silvestri F, Leri A, Beltrami CA, Anversa P (2001) Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 344:1750\u20131757","journal-title":"N Engl J Med"},{"key":"9_CR13","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","volume":"114","author":"A.P. Beltrami","year":"2003","unstructured":"Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114:763\u2013776","journal-title":"Cell"},{"key":"9_CR14","doi-asserted-by":"publisher","first-page":"H2196","DOI":"10.1152\/ajpheart.01017.2005","volume":"290","author":"M.F. Berry","year":"2006","unstructured":"Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL (2006) Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol 290:H2196\u2013H2203","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9_CR15","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s00259-006-0093-7","volume":"33","author":"L. Bindslev","year":"2006","unstructured":"Bindslev L, Haack-Sorensen M, Bisgaard K, Kragh L, Mortensen S, Hesse B, Kjaer A, Kastrup J (2006) Labelling of human mesenchymal stem cells with indium-111 for SPECT imaging: effect on cell proliferation and differentiation. Eur J Nucl Med Mol Imaging 33:1171\u20131177","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"9_CR16","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1161\/CIRCULATIONAHA.105.590653","volume":"114","author":"A.J. Boyle","year":"2006","unstructured":"Boyle AJ, Schulman SP, Hare JM, Oettgen P (2006) Controversies in cardiovascular medicine: ready for the next step. Circulation 114:339\u2013352","journal-title":"Circulation"},{"key":"9_CR17","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/jor.1100090504","volume":"9","author":"A.I. Caplan","year":"1991","unstructured":"Caplan AI (1991) Mesenchymal stem cells. J Orthop Res 9:641\u2013650","journal-title":"J Orthop Res"},{"key":"9_CR18","first-page":"1443","volume":"117","author":"S.L. Chen","year":"2004","unstructured":"Chen SL, Fang WW, Qian J, Ye F, Liu YH, Shan SJ, Zhang JJ, Lin S, Liao LM, Zhao RC (2004a) Improvement of cardiac function after transplantation of autologous bone marrow mesenchymal stem cells in patients with acute myocardial infarction. Chin Med J (Engl) 117:1443\u20131448","journal-title":"Chin Med J"},{"key":"9_CR19","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.amjcard.2004.03.034","volume":"94","author":"S.L. Chen","year":"2004","unstructured":"Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, Zhang JJ, Chunhua RZ, Liao LM, Lin S, Sun JP (2004b) Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 94:92\u201395","journal-title":"Am J Cardiol"},{"key":"9_CR20","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/S0301-472X(00)00635-4","volume":"29","author":"S.M. Devine","year":"2001","unstructured":"Devine SM, Bartholomew AM, Mahmud N, Nelson M, Patil S, Hardy W, Sturgeon C, Hewett T, Chung T, Stock W, Sher D, Weissman S, Ferrer K, Mosca J, Deans R, Moseley A, Hoffman R (2001) Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion. Exp Hematol 29:244\u2013255","journal-title":"Exp Hematol"},{"key":"9_CR21","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1182\/blood-2002-06-1830","volume":"101","author":"S.M. Devine","year":"2003","unstructured":"Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R (2003) Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 101:2999\u20133001","journal-title":"Blood"},{"key":"9_CR22","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1182\/blood.V99.10.3838","volume":"99","author":"N.M. Di","year":"2002","unstructured":"Di NM, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, Grisanti S, Gianni AM (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838\u20133843","journal-title":"Blood"},{"key":"9_CR23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000141739","volume":"45","author":"A.J. Friedenstein","year":"1961","unstructured":"Friedenstein AJ (1961) Osteogenetic activity of transplanted transitional epithelium. Acta Anat (Basel) 45:31\u201359","journal-title":"Acta Anat"},{"key":"9_CR24","first-page":"393","volume":"3","author":"A.J. Friedenstein","year":"1970","unstructured":"Friedenstein AJ, Chailakhjan RK, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3:393\u2013403","journal-title":"Cell Tissue Kinet"},{"key":"9_CR25","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1007\/s10350-005-0052-6","volume":"48","author":"D. Garcia-Olmo","year":"2005","unstructured":"Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes JA (2005) A phase I clinical trial of the treatment of Crohn\u2019s fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 48:1416\u20131423","journal-title":"Dis Colon Rectum"},{"key":"9_CR26","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nm0405-367","volume":"11","author":"M. Gnecchi","year":"2005","unstructured":"Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H, Noiseux N, Zhang L, Pratt RE, Ingwall JS, Dzau VJ (2005) Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 11:367\u2013368","journal-title":"Nat Med"},{"key":"9_CR27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/8756-3282(92)90364-3","volume":"13","author":"S.E. Haynesworth","year":"1992","unstructured":"Haynesworth SE, Goshima J, Goldberg VM, Caplan AI (1992) Characterization of cells with osteogenic potential from human marrow. Bone 13:81\u201388","journal-title":"Bone"},{"key":"9_CR28","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/(SICI)1097-4652(199603)166:3<585::AID-JCP13>3.0.CO;2-6","volume":"166","author":"S.E. Haynesworth","year":"1996","unstructured":"Haynesworth SE, Baber MA, Caplan AI (1996) Cytokine expression by human marrow derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cell Physiol 166:585\u2013592","journal-title":"J Cell Physiol"},{"key":"9_CR29","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0092-8674(02)00754-7","volume":"109","author":"B. Heissig","year":"2002","unstructured":"Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S (2002) Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109:625\u2013637","journal-title":"Cell"},{"key":"9_CR30","doi-asserted-by":"publisher","first-page":"8932","DOI":"10.1073\/pnas.132252399","volume":"99","author":"E.M. Horwitz","year":"2002","unstructured":"Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, Muul L, Hofmann T (2002) Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A 99:8932\u20138937","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nature00870","volume":"418","author":"Y. Jiang","year":"2002","unstructured":"Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM (2002a) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41\u201349","journal-title":"Nature"},{"key":"9_CR32","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0301-472X(02)00869-X","volume":"30","author":"Y. Jiang","year":"2002","unstructured":"Jiang Y, Vaessen B, Lenvik T, Blackstad M, Reyes M, Verfaillie CM (2002b) Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 30:896\u2013904","journal-title":"Exp Hematol"},{"key":"9_CR33","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/ccd.20406","volume":"65","author":"D.G. Katritsis","year":"2005","unstructured":"Katritsis DG, Sotiropoulou PA, Karvouni E, Karabinos I, Korovesis S, Perez SA, Voridis EM, Papamichail M (2005) Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium. Catheter Cardiovasc Interv 65:321\u2013329","journal-title":"Catheter Cardiovasc Interv"},{"key":"9_CR34","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1161\/01.RES.0000118601.37875.AC","volume":"94","author":"T. Kinnaird","year":"2004","unstructured":"Kinnaird T, Stabile E, Burnett MS, Lee CW, Barr S, Fuchs S, Epstein SE (2004a) Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 94:678\u2013685","journal-title":"Circ Res"},{"key":"9_CR35","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1161\/01.CIR.0000124062.31102.57","volume":"109","author":"T. Kinnaird","year":"2004","unstructured":"Kinnaird T, Stabile E, Burnett MS, Shou M, Lee CW, Barr S, Fuchs S, Epstein SE (2004b) Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109:1543\u20131549","journal-title":"Circulation"},{"key":"9_CR36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1200\/JCO.2000.18.2.307","volume":"18","author":"O.N. Koc","year":"2000","unstructured":"Koc ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, Lazarus HM (2000) Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 18:307\u2013316","journal-title":"J Clin Oncol"},{"key":"9_CR37","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/sj.bmt.1703650","volume":"30","author":"O.N. Koc","year":"2002","unstructured":"Koc ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W (2002) Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 30:215\u2013222","journal-title":"Bone Marrow Transplant"},{"key":"9_CR38","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1161\/CIRCULATIONAHA.105.537480","volume":"112","author":"D.L. Kraitchman","year":"2005","unstructured":"Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, Segars WP, Chen HH, Fritzges D, Izbudak I, Young RG, Marcelino M, Pittenger MF, Solaiyappan M, Boston RC, Tsui BM, Wahl RL, Bulte JW (2005) Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation 112:1451\u20131461","journal-title":"Circulation"},{"key":"9_CR39","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.bbmt.2005.02.001","volume":"11","author":"H.M. Lazarus","year":"2005","unstructured":"Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, Shpall EJ, Mc-Carthy P, Atkinson K, Cooper BW, Gerson SL, Laughlin MJ, Loberiza FR Jr, Moseley AB, Bacigalupo A (2005) Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 11:389\u2013398","journal-title":"Biol Blood Marrow Transplant"},{"key":"9_CR40","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","volume":"363","author":"B.K. Le","year":"2004","unstructured":"Le BK, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, Ringden O (2004) Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363:1439\u20131441","journal-title":"Lancet"},{"key":"9_CR41","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1152\/physrev.00013.2005","volume":"85","author":"A. Leri","year":"2005","unstructured":"Leri A, Kajstura J, Anversa P (2005) Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev 85:1373\u20131416","journal-title":"Physiol Rev"},{"key":"9_CR42","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/81395","volume":"6","author":"K.W. Liechty","year":"2000","unstructured":"Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW(2000) Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 6:1282\u20131286","journal-title":"Nat Med"},{"key":"9_CR43","doi-asserted-by":"publisher","first-page":"e73","DOI":"10.1161\/01.RES.0000186276.06104.04","volume":"97","author":"F. Limana","year":"2005","unstructured":"Limana F, Germani A, Zacheo A, Kajstura J, Di CA, Borsellino G, Leoni O, Palumbo R, Battistini L, Rastaldo R, Muller S, Pompilio G, Anversa P, Bianchi ME, Capogrossi MC (2005) Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ Res 97:e73\u2013e83","journal-title":"Circ Res"},{"key":"9_CR44","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1083\/jcb.133.2.325","volume":"133","author":"Y. Liu","year":"1996","unstructured":"Liu Y, Kitsis RN (1996) Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein. J Cell Biol 133:325\u2013334","journal-title":"J Cell Biol"},{"key":"9_CR45","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00395-005-0521-z","volume":"100","author":"J. Ma","year":"2005","unstructured":"Ma J, Ge J, Zhang S, Sun A, Shen J, Chen L, Wang K, Zou Y (2005) Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction. Basic Res Cardiol 100:217\u2013223","journal-title":"Basic Res Cardiol"},{"key":"9_CR46","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/(SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7","volume":"176","author":"M.K. Majumdar","year":"1998","unstructured":"Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL (1998) Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol 176:57\u201366","journal-title":"J Cell Physiol"},{"key":"9_CR47","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1172\/JCI5298","volume":"103","author":"S. Makino","year":"1999","unstructured":"Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S (1999) Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103:697\u2013705","journal-title":"J Clin Invest"},{"key":"9_CR48","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1038\/nm912","volume":"9","author":"A.A. Mangi","year":"2003","unstructured":"Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ (2003) Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 9:1195\u20131201","journal-title":"Nat Med"},{"key":"9_CR49","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2307\/3570877","volume":"13","author":"E.A. McCulloch","year":"1960","unstructured":"McCulloch EA, Till JE (1960) The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice. Radiat Res 13:115\u2013125","journal-title":"Radiat Res"},{"key":"9_CR50","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/153537020122600603","volume":"226","author":"J.J. Minguell","year":"2001","unstructured":"Minguell JJ, Erices A, Conget P (2001) Mesenchymal stem cells. Exp Biol Med (Maywood) 226:507\u2013520","journal-title":"Exp Biol Med"},{"key":"9_CR51","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nm1391","volume":"12","author":"Y. Miyahara","year":"2006","unstructured":"Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, Hao H, Ishino K, Ishida H, Shimizu T, Kangawa K, Sano S, Okano T, Kitamura S, Mori H (2006) Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med 12:459\u2013465","journal-title":"Nat Med"},{"key":"9_CR52","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1161\/01.RES.0000194330.66545.f5","volume":"97","author":"F. Mouquet","year":"2005","unstructured":"Mouquet F, Pfister O, Jain M, Oikonomopoulos A, Ngoy S, Summer R, Fine A, Liao R (2005) Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res 97:1090\u20131092","journal-title":"Circ Res"},{"key":"9_CR53","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1242\/jcs.113.7.1161","volume":"113","author":"A. Muraglia","year":"2000","unstructured":"Muraglia A, Cancedda R, Quarto R (2000) Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J Cell Sci 113:1161\u20131166","journal-title":"J Cell Sci"},{"key":"9_CR54","doi-asserted-by":"publisher","first-page":"H2670","DOI":"10.1152\/ajpheart.01071.2003","volume":"287","author":"N. Nagaya","year":"2004","unstructured":"Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M, Yamagishi M, Mori H, Kangawa K, Kitamura S (2004) Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 287:H2670\u2013H2676","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9_CR55","doi-asserted-by":"publisher","first-page":"12313","DOI":"10.1073\/pnas.2132126100","volume":"100","author":"H. Oh","year":"2003","unstructured":"Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, Pocius J, Michael LH, Behringer RR, Garry DJ, Entman ML, Schneider MD (2003) Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 100:12313\u201312318","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9_CR56","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1126\/science.283.5403.845","volume":"283","author":"A. Peled","year":"1999","unstructured":"Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, Nagler A, Ben-Hur H, Many A, Shultz L, Lider O, Alon R, Zipori D, Lapidot T (1999) Dependence of human stem cell engraftment and repopulation of NOD\/SCID mice on CXCR4. Science 283:845\u2013848","journal-title":"Science"},{"key":"9_CR57","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"M.F. Pittenger","year":"1999","unstructured":"Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143\u2013147","journal-title":"Science"},{"key":"9_CR58","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1161\/01.RES.0000123827.60210.72","volume":"94","author":"I. Potapova","year":"2004","unstructured":"Potapova I, Plotnikov A, Lu Z, Danilo P Jr, Valiunas V, Qu J, Doronin S, Zuckerman J, Shlapakova IN, Gao J, Pan Z, Herron AJ, Robinson RB, Brink PR, Rosen MR, Cohen IS (2004) Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circ Res 94:952\u2013959","journal-title":"Circ Res"},{"key":"9_CR59","doi-asserted-by":"crossref","unstructured":"Price MJ, Chou CC, Frantzen M, Miyamoto T, Kar S, Lee S, Shah PK, Martin BJ, Lill M, Forrester JS, Chen PS, Makkar RR (2005) Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties. Int J Cardiol Oct 21","DOI":"10.1016\/j.ijcard.2005.07.036"},{"key":"9_CR60","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1080\/146532401753277229","volume":"3","author":"D.J. Prockop","year":"2001","unstructured":"Prockop DJ, Sekiya I, Colter DC (2001) Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells. Cytotherapy 3:393\u2013396","journal-title":"Cytotherapy"},{"key":"9_CR61","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1056\/NEJMoa012081","volume":"346","author":"F. Quaini","year":"2002","unstructured":"Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B, Kajstura J, Leri A, Anversa P (2002) Chimerism of the transplanted heart. N Engl J Med 346:5\u201315","journal-title":"N Engl J Med"},{"key":"9_CR62","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0003-4975(02)03591-9","volume":"74","author":"T. Saito","year":"2002","unstructured":"Saito T, Kuang JQ, Bittira B, Al-Khaldi A, Chiu RC (2002) Xenotransplant cardiac chimera: immune tolerance of adult stem cells. Ann Thorac Surg 74:19\u201324","journal-title":"Ann Thorac Surg"},{"key":"9_CR63","doi-asserted-by":"crossref","unstructured":"Schmidt A, Ladage D, Steingen C, Brixius K, Schinkothe T, Klinz FJ, Schwinger RH, Mehlhorn U, Bloch W (2006) Mesenchymal stem cells transmigrate over the endothelial barrier. Eur J Cell Biol July 3","DOI":"10.1016\/j.ejcb.2006.05.015"},{"key":"9_CR64","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1016\/S0003-4975(02)03517-8","volume":"73","author":"J.G. Shake","year":"2002","unstructured":"Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM, Pittenger MF, Martin BJ (2002) Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg 73:1919\u20131925","journal-title":"Ann Thorac Surg"},{"key":"9_CR65","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1161\/01.CIR.0000151812.86142.45","volume":"111","author":"G.V. Silva","year":"2005","unstructured":"Silva GV, Litovsky S, Assad JA, Sousa AL, Martin BJ, Vela D, Coulter SC, Lin J, Ober J, Vaughn WK, Branco RV, Oliveira EM, He R, Geng YJ, Willerson JT, Perin EC (2005) Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 111:150\u2013156","journal-title":"Circulation"},{"key":"9_CR66","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0002-9149(70)90575-8","volume":"25","author":"N.J. Sissman","year":"1970","unstructured":"Sissman NJ (1970) Developmental landmarks in cardiac morphogenesis: comparative chronology. Am J Cardiol 25:141\u2013148","journal-title":"Am J Cardiol"},{"key":"9_CR67","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.regpep.2003.09.005","volume":"117","author":"Y.L. Tang","year":"2004","unstructured":"Tang YL, Zhao Q, Zhang YC, Cheng L, Liu M, Shi J, Yang YZ, Pan C, Ge J, Phillips MI (2004) Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept 117:3\u201310","journal-title":"Regul Pept"},{"key":"9_CR68","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.jacc.2005.05.079","volume":"46","author":"Y.L. Tang","year":"2005","unstructured":"Tang YL, Tang Y, Zhang YC, Qian K, Shen L, Phillips MI (2005) Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol 46:1339\u20131350","journal-title":"J Am Coll Cardiol"},{"key":"9_CR69","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1161\/hc0102.101442","volume":"105","author":"C. Toma","year":"2002","unstructured":"Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD (2002) Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105:93\u201398","journal-title":"Circulation"},{"key":"9_CR70","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1067\/mtc.2002.120716","volume":"123","author":"S. Tomita","year":"2002","unstructured":"Tomita S, Mickle DA, Weisel RD, Jia ZQ, Tumiati LC, Allidina Y, Liu P, Li RK (2002) Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg 123:1132\u20131140","journal-title":"J Thorac Cardiovasc Surg"},{"key":"9_CR71","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1097\/01.TP.0000045055.63901.A9","volume":"75","author":"W.T. Tse","year":"2003","unstructured":"Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC (2003) Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 75:389\u2013397","journal-title":"Transplantation"},{"key":"9_CR72","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/01.RES.0000183733.53101.11","volume":"97","author":"K. Urbanek","year":"2005","unstructured":"Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De AA, Hosoda T, Chimenti S, Baker M, Limana F, Nurzynska D, Torella D, Rotatori F, Rastaldo R, Musso E, Quaini F, Leri A, Kajstura J, Anversa P (2005a) Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res 97:663\u2013673","journal-title":"Circ Res"},{"key":"9_CR73","doi-asserted-by":"publisher","first-page":"8692","DOI":"10.1073\/pnas.0500169102","volume":"102","author":"K. Urbanek","year":"2005","unstructured":"Urbanek K, Torella D, Sheikh F, De AA, Nurzynska D, Silvestri F, Beltrami CA, Bussani R, Beltrami AP, Quaini F, Bolli R, Leri A, Kajstura J, Anversa P (2005b) Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A 102:8692\u20138697","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9_CR74","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1113\/jphysiol.2003.058719","volume":"555","author":"V. Valiunas","year":"2004","unstructured":"Valiunas V, Doronin S, Valiuniene L, Potapova I, Zuckerman J, Walcott B, Robinson RB, Rosen MR, Brink PR, Cohen IS (2004) Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J Physiol 555:617\u2013626","journal-title":"J Physiol"},{"key":"9_CR75","first-page":"126","volume":"88","author":"W. Vogel","year":"2003","unstructured":"Vogel W, Grunebach F, Messam CA, Kanz L, Brugger W, Buhring HJ (2003) Heterogeneity among human bone marrow-derived mesenchymal stem cells and neural progenitor cells. Haematologica 88:126\u2013133","journal-title":"Haematologica"},{"key":"9_CR76","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/01.RES.85.2.128","volume":"85","author":"von Harsdorf","year":"1999","unstructured":"von Harsdorf, Hauck L, Mehrhof F, Wegenka U, Cardoso MC, Dietz R (1999) E2F-1 over-expression in cardiomyocytes induces downregulation of p21CIP1 and p27KIP1 and release of active cyclin-dependent kinases in the presence of insulin-like growth factor I. Circ Res 85:128\u2013136","journal-title":"Circ Res"},{"key":"9_CR77","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0140-6736(04)15695-X","volume":"363","author":"P.R. Vulliet","year":"2004","unstructured":"Vulliet PR, Greeley M, Halloran SM, MacDonald KA, Kittleson MD (2004) Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet 363:783\u2013784","journal-title":"Lancet"},{"key":"9_CR78","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1161\/01.CIR.0000068375.40887.FA","volume":"107","author":"E.M. Wilson","year":"2003","unstructured":"Wilson EM, Moainie SL, Baskin JM, Lowry AS, Deschamps AM, Mukherjee R, Guy TS, St John-Sutton MG, Gorman JH III, Edmunds LH Jr, Gorman RC, Spinale FG (2003) Region and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. Circulation 107:2857\u20132863","journal-title":"Circulation"},{"key":"9_CR79","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C","volume":"61","author":"D. Woodbury","year":"2000","unstructured":"Woodbury D, Schwarz EJ, Prockop DJ, Black IB (2000) Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61:364\u2013370","journal-title":"J Neurosci Res"},{"key":"9_CR80","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/00019501-200506000-00006","volume":"16","author":"X. Xu","year":"2005","unstructured":"Xu X, Xu Z, Xu Y, Cui G (2005a) Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats. Coron Artery Dis 16:245\u2013255","journal-title":"Coron Artery Dis"},{"key":"9_CR81","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1253\/circj.69.1275","volume":"69","author":"X. Xu","year":"2005","unstructured":"Xu X, Xu Z, Xu Y, Cui G (2005b) Selective down-regulation of extracellular matrix gene expression by bone marrow derived stem cell transplantation into infarcted myocardium. Circ J 69:1275\u20131283","journal-title":"Circ J"},{"key":"9_CR82","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000093609","volume":"107","author":"J. Yang","year":"2006","unstructured":"Yang J, Zhou W, Zheng W, Ma Y, Lin L, Tang T, Liu J, Yu J, Zhou X, Hu J (2006) Effects of myocardial transplantation of marrow mesenchymal stem cells transfected with vascular endothelial growth factor for the improvement of heart function and angiogenesis after myocardial infarction. Cardiology 107:17\u201329","journal-title":"Cardiology"},{"key":"9_CR83","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1172\/JCI200522326","volume":"115","author":"Y.S. Yoon","year":"2005","unstructured":"Yoon YS, Wecker A, Heyd L, Park JS, Tkebuchava T, Kusano K, Hanley A, Scadova H, Qin G, Cha DH, Johnson KL, Aikawa R, Asahara T, Losordo DW (2005) Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 115:326\u2013338","journal-title":"J Clin Invest"},{"key":"9_CR84","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1016\/j.lfs.2003.10.035","volume":"74","author":"S. Zhang","year":"2004","unstructured":"Zhang S, Guo J, Zhang P, Liu Y, Jia Z, Ma K, Li W, Li L, Zhou C (2004) Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats. Life Sci 74:2853\u20132864","journal-title":"Life Sci"},{"key":"9_CR85","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1006\/mthe.2002.0585","volume":"5","author":"X.Y. Zhang","year":"2002","unstructured":"Zhang XY, La Russa VF, Bao L, Kolls J, Schwarzenberger P, Reiser J (2002) Lentiviral vectors for sustained transgene expression in human bone marrow-derived stromal cells. Mol Ther 5:555\u2013565","journal-title":"Mol Ther"}],"container-title":["Handbook of Experimental Pharmacology","Bone Marrow-Derived Progenitors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-540-68976-8_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T22:28:48Z","timestamp":1675895328000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-540-68976-8_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"ISBN":["9783540689751","9783540689768"],"references-count":85,"URL":"https:\/\/doi.org\/10.1007\/978-3-540-68976-8_9","relation":{},"ISSN":["0171-2004"],"issn-type":[{"value":"0171-2004","type":"print"}],"subject":[],"published":{"date-parts":[[2007]]}}}