{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:37:00Z","timestamp":1791581820375,"version":"4.3.4"},"publisher-location":"Berlin, Heidelberg","reference-count":87,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540708575","type":"print"},{"value":"9783540708681","type":"electronic"}],"license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"DOI":"10.1007\/978-3-540-70868-1_4","type":"book-chapter","created":{"date-parts":[[2009,4,28]],"date-time":"2009-04-28T05:20:04Z","timestamp":1240896004000},"page":"55-78","source":"Crossref","is-referenced-by-count":23,"title":["Production of Antibodies in Plants: Approaches and Perspectives"],"prefix":"10.1007","author":[{"given":"K.","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Brodzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Steplewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"4_CR1_4","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1073\/pnas.031419998","volume":"98","author":"H Bakker","year":"2001","unstructured":"Bakker H, Bardor M, Molthoff JW, Gomord V, Elbers I, Stevens LH, Jordi W, Lommen A, Faye L, Lerouge P, Bosch D (2001) Galactose-extended glycans of antibodies produced by transgenic plants. Proc Natl Acad Sci USA 98:2899\u20132904","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR2_4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1094\/MPMI-9-0382","volume":"9","author":"TJ Baum","year":"1996","unstructured":"Baum TJ, Hiatt A, Parrott WA, Pratt LH, Hussey RS (1996) Expression in tobacco of a functional monoclonal antibody specific to stylet secretions of the root-knot nematode. Molecular Plant-Microbe Interaction 9:382\u2013387","journal-title":"Molecular Plant-Microbe Interaction"},{"key":"4_CR3_4","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/(SICI)1098-2299(199711\/12)42:3\/4<172::AID-DDR9>3.0.CO;2-N","volume":"42","author":"JG Boothe","year":"1997","unstructured":"Boothe JG, Saponja JA, Parmenter DL (1997) Molecular farming in plants: oilseeds as vehicles for the production of pharmaceutical proteins. Drug Develop Res 42:172\u2013181","journal-title":"Drug Develop Res"},{"key":"4_CR4_4","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/8643","volume":"17","author":"N V Borisjuk","year":"1999","unstructured":"Borisjuk N V, Borisjuk LG, Logendra S, Petersen F, Gleba Y, Raskin I (1999) Production of recombinant proteins in plant root exudates. Nat Biotechnol 17:466\u2013469","journal-title":"Nat Biotechnol"},{"key":"4_CR5_4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jim.2004.11.008","volume":"296","author":"EC Brockmann","year":"2005","unstructured":"Brockmann EC, Cooper M, Stromsten N, Vehniainen M, Saviranta P (2005) Selecting for antibody scFV fragments with improved stability using phage display with denaturation under reducing conditions. J Immunol Methods 296:159\u2013170","journal-title":"J Immunol Methods"},{"key":"4_CR6_4","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/nri891","volume":"2","author":"DR Burton","year":"2002","unstructured":"Burton DR (2002) Antibodies, viruses and vaccines. Nat Rev Immunol 2:706\u2013713","journal-title":"Nat Rev Immunol"},{"key":"4_CR7_4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0065-2776(08)60674-4","volume":"57","author":"DR Burton","year":"1994","unstructured":"Burton DR, Barbas CFr (1994) Human antibodies from combinatorial libraries. Adv Immunol 57:191\u2013280","journal-title":"Adv Immunol"},{"key":"4_CR8_4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/glycob\/9.4.365","volume":"9","author":"M Cabanes-Macheteau","year":"1999","unstructured":"Cabanes-Macheteau M, Fitchette-Laine AC, Loutelier-Bourhis C, Lange C, Vine ND, Ma JK, Lerouge P, Faye L (1999) N-Glycosylation of a mouse IgG expressed in transgenic tobacco plants. Glycobiology 9:365\u2013372","journal-title":"Glycobiology"},{"key":"4_CR9_4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0022-1759(00)00339-2","volume":"248","author":"P Carter","year":"2001","unstructured":"Carter P (2001) Bispecific human IgG by design. J Immunol Methods 248:7\u201315","journal-title":"J Immunol Methods"},{"key":"4_CR10_4","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/nrmicro974","volume":"2","author":"A Casadevall","year":"2004","unstructured":"Casadevall A, Dadachova E, Pirofski L (2004) Passive antibody therapy for infectious diseases. Nat Microbiol 2:695\u2013702","journal-title":"Nat Microbiol"},{"key":"4_CR11_4","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/S0958-1669(00)00198-1","volume":"12","author":"HE Chadd","year":"2001","unstructured":"Chadd HE, Chamow SM (2001) Therapeutic antibody expression technology. Curr Opin Biotechnol 12:188\u2013194","journal-title":"Curr Opin Biotechnol"},{"key":"4_CR12_4","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1023\/A:1008976219939","volume":"9","author":"D Chargelegue","year":"2000","unstructured":"Chargelegue D, Vine ND, van Dolleweerd CJ, Drake PM, Ma JK (2000) A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice. Transgenic Res 9:187\u2013194","journal-title":"Transgenic Res"},{"key":"4_CR13_4","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.jmb.2004.07.054","volume":"342","author":"DW Colby","year":"2004","unstructured":"Colby DW, Garg P, Holden T, Chao G, Webster JM, Messer A, Ingram VM, Wittrup KD (2004) Development of a human light chain variable domain (VL) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display. J Mol Biol 342:901\u2013912","journal-title":"J Mol Biol"},{"key":"4_CR14_4","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.4049\/jimmunol.162.4.2162","volume":"162","author":"MJ Coloma","year":"1999","unstructured":"Coloma MJ, Trinh RK, Martinez AR, Morrison SL (1999) Position effects of variable region carbohydrate on the affinity and in vivo behavior of an anti-(1-->6) dextran antibody. J Immunol 162:2162\u20132170","journal-title":"J Immunol"},{"key":"4_CR15_4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1023\/A:1006029617949","volume":"38","author":"U Conrad","year":"1998","unstructured":"Conrad U, Fiedler U (1998) Compartment-specific accumulation of recombinant immunoglobu-lins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol Biol 38:101\u2013109","journal-title":"Plant Mol Biol"},{"key":"4_CR16_4","first-page":"1","volume-title":"Molecular Farming: Plant-made Pharmaceuticals and Technical Protein","author":"M-A D'Aoust","year":"2004","unstructured":"D'Aoust M-A, Lerouge P, Busse U, Bilodeau P, Trepanier S, Gomord V, Faye L, Vezina L-P (2004) Efficient and reliable production of pharmaceutical in alfalfa. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Protein. Wiley, Weinheim, pp. 1\u201311"},{"key":"4_CR17_4","first-page":"371","volume-title":"Plant Biotechnology 2002 and Beyond, Plant Biotechnology 2002 and Beyond","author":"H Daniell","year":"2002a","unstructured":"Daniell H (2002a) Medical molecular pharming: expression of antibodies, biopharmaceuticals and edible vaccines via the chloroplast genome. In: V. I.K (ed) Plant Biotechnology 2002 and Beyond, Plant Biotechnology 2002 and Beyond. Kluwer Academic Publishers, Orlando, pp. 371\u2013376"},{"key":"4_CR18_4","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1096\/fj.02-0148com","volume":"16","author":"PMW Drake","year":"2002","unstructured":"Drake PMW, Chargelegue D, Vine ND, Van Dolleweerd CJ, Obregon P, Ma JK-C (2002) Transgenic plants expressing antibodies: a model for phytoremediation. FASEB J 16:1855\u20131860","journal-title":"FASEB J"},{"key":"4_CR19_4","volume-title":"Wundinduzierbare und Sekretion von T4 Lysozym und monoklonalen Antikorpern in Nicotiana tabcum","author":"K Duering","year":"1988","unstructured":"Duering K (1988) Wundinduzierbare und Sekretion von T4 Lysozym und monoklonalen Antikorpern in Nicotiana tabcum. PhD thesis, Universit\u00e4t Koln, FRG"},{"key":"4_CR20_4","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1046\/j.1432-1327.1999.00435.x","volume":"262","author":"R Fischer","year":"1999","unstructured":"Fischer R, Schumann D, Zimmermann S, Drossard J, Sack M, Schillberg S (1999) Expression and characterization of bispecific single-chain Fv fragments produced in transgenic plants. Eur J Biochem 262:810\u2013816","journal-title":"Eur J Biochem"},{"key":"4_CR21_4","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/j.1365-313X.1994.00673.x","volume":"5","author":"AC Fitchette-Laine","year":"1994","unstructured":"Fitchette-Laine AC, Gomord V, Chekkafi A, Faye L (1994) Distribution of xylosylation and fucosylation in the plant Golgi apparatus. Plant J 5:673\u2013682","journal-title":"Plant J"},{"key":"4_CR22_4","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1016\/j.vaccine.2005.01.006","volume":"23","author":"Y Gleba","year":"2005","unstructured":"Gleba Y, Klimyuk V, Marillonnnet S (2005) Magnifection-a new platform for expressing recom-binant vaccines in plants. Vaccine 23:2042\u20132048","journal-title":"Vaccine"},{"key":"4_CR23_4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1467-7652.2004.00062.x","volume":"2","author":"V Gomord","year":"2004","unstructured":"Gomord V, Sourrouille C, Fitchette A-C, Bardor M, Pagny S, Lerouge P, Faye L (2004) Production and glycosylation of plant-made pharmaceuticals: the antibodies as a challenge. Plant Biotechnol J 2:83\u2013100","journal-title":"Plant Biotechnol J"},{"key":"4_CR24_4","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S1470-2045(04)01467-6","volume":"5","author":"M Harris","year":"2004","unstructured":"Harris M (2004) Monoclonal antibodies as therapeutic agents for cancer. Lancet Oncol 5:292\u2013302","journal-title":"Lancet Oncol"},{"key":"4_CR25_4","first-page":"717","volume":"40","author":"DM Herlyn","year":"1980","unstructured":"Herlyn DM, Steplewski Z, Herlyn MF, Koprowski H (1980) Inhibition of growth of colorectal carcinoma in nude mice by monoclonal antibody. Cancer Res 40:717\u2013721","journal-title":"Cancer Res"},{"key":"4_CR26_4","first-page":"S3","volume":"5","author":"M Herlyn","year":"1986","unstructured":"Herlyn M, Steplewski Z, Herlyn D, Koprowski H (1986) CO17-1A and related monoclonal antibodies: Their production and characterization. Hybridoma 5:3\u2013S10","journal-title":"Hybridoma"},{"key":"4_CR27_4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/342076a0","volume":"342","author":"A Hiatt","year":"1989","unstructured":"Hiatt A, Caffertey R, Bowdish K (1989) Production of antibodies in transgenic plants. Nature 342:76\u201378","journal-title":"Nature"},{"key":"4_CR28_4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/74621","volume":"6","author":"AN Houghton","year":"2000","unstructured":"Houghton AN, Scheinberg DA (2000) Monoclonal antibody therapies\u2014a \u2018constant\u2019 threat to cancer. Nat Med 6:373\u2013374","journal-title":"Nat Med"},{"key":"4_CR29_4","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1016\/j.vaccine.2005.01.013","volume":"23","author":"AK Hull","year":"2005","unstructured":"Hull AK, Criscuolo CJ, Mett V, Groen H, Steeman W, Westra H, Chapman G, Legutki B, Baillie L, Yusibov V (2005) Human-derived, plant-produced monoclonal antibody for the treatment of anthrax. Vaccine 23:2082\u20132086","journal-title":"Vaccine"},{"key":"4_CR30_4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nbt772","volume":"21","author":"SA Jobling","year":"2003","unstructured":"Jobling SA, Jarman C, Teh MM, Holmberg N, Blake C, Verhoeyen ME (2003) Immunomodulation of enzyme function in plants by single-domain antibody fragments. Nat Biotechnol 21:77\u201380","journal-title":"Nat Biotechnol"},{"key":"4_CR31_4","first-page":"5144","volume":"52","author":"M Juwied","year":"1992","unstructured":"Juwied M, Neumann R, Paik C, MJ, P-B, Sato J, van Osdol W, Weinstein JN (1992) Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res 52:5144\u20135153","journal-title":"Cancer Res"},{"key":"4_CR32_4","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1093\/humrep\/17.8.2054","volume":"17","author":"S Kathuria","year":"2002","unstructured":"Kathuria S, Sriraman R, Nath R, Sack M, Pal R, Artsaenko O, Talwar GP, Fischer R, Finnern R (2002) Efficacy of plant-produced recombinant antibodies against HCG. Hum Reprod 17:2054\u20132061","journal-title":"Hum Reprod"},{"key":"4_CR33_4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.virusres.2005.03.016","volume":"111","author":"K Ko","year":"2005","unstructured":"Ko K, Koprowski, H (2005) Plant biopharming of monoclonal antibodies. Virus Res 111:93\u2013100","journal-title":"Virus Res"},{"key":"4_CR34_4","doi-asserted-by":"publisher","first-page":"7026","DOI":"10.1073\/pnas.0502533102","volume":"102","author":"K Ko","year":"2005","unstructured":"Ko K, Steplewski Z, Glogowska M, Koprowski H (2005) Inhibition of tumor growth by plant-derived mAb. Proc Natl Acad Sci USA 102:7026\u20137030","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR35_4","doi-asserted-by":"publisher","first-page":"8013","DOI":"10.1073\/pnas.0832472100","volume":"100","author":"K Ko","year":"2003","unstructured":"Ko K, Tekoah Y, Rudd PM, Harvey DJ, Dwek RA, Spitsin S, Hanlon CA, Rupprecht C, Dietzschold B, Golovkin M, Koprowski H (2003) Function and glycosylation of plant-derived antiviral monoclonal antibody. Proc Natl Acad Sci USA 100:8013\u20138018","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR36_4","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/256495a0","volume":"256","author":"G Kohler","year":"1975","unstructured":"Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495\u2013497","journal-title":"Nature"},{"key":"4_CR37_4","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/j.1467-7652.2004.00100.x","volume":"2","author":"A Koprivova","year":"2004","unstructured":"Koprivova A, Stemmer C, Altmann F, Hoffmann A, Kopriva S, Gorr G, Reski R, Decker EL (2004) Targeted knockouts of Physcomitrella lacking plant-specific immunogenic N-glycans. Plant Biotechnol J 2:517\u2013523","journal-title":"Plant Biotechnol J"},{"key":"4_CR38_4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4049\/jimmunol.72.1.79","volume":"72","author":"H Koprowski","year":"1952","unstructured":"Koprowski H, Black J (1952) Studies on chick-embryo-adapted rabies virus. J Immunol 72:79\u201384","journal-title":"J Immunol"},{"key":"4_CR39_4","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1016\/S0264-410X(00)00511-9","volume":"19","author":"H Koprowski","year":"2001","unstructured":"Koprowski H, Yusibov V (2001) The green revolution: plants as heterologous expression vectors. Vaccine 19:2735\u20132741","journal-title":"Vaccine"},{"key":"4_CR40_4","first-page":"491","volume":"76","author":"J Lang","year":"1998","unstructured":"Lang J, Simanjuntak GH, Soerjosembodo S, Koesharyono C (1998) Suppressant effect of human or equine rabies immunoglobulins on the immunogenicity of post-exposure rabies vaccination under the 2-1-1 regimen: a field trial in Indonesia. MAS054 Clinical Investigator Group. Bull World Health Organ 76:491\u2013495","journal-title":"Bull World Health Organ"},{"key":"4_CR41_4","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1128\/AEM.64.11.4566-4572.1998","volume":"64","author":"Gall F Le","year":"1998","unstructured":"Le Gall F, Bove J-M, Garnier M (1998) Engineering of a single-chain variable-fragment (scFv) antibody specific for the stolbur phytoplasma (mollicute) and its expression in Escherichia coli and tobacco plants. Appl Environ Microbiol 64:4566\u20134572","journal-title":"Appl Environ Microbiol"},{"key":"4_CR42_4","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/nrg1177","volume":"4","author":"JK Ma","year":"2003","unstructured":"Ma JK, Drake PM, Christou P (2003) The production of recombinant pharmaceutical proteins in plants. Nat Rev Genet 4:794\u2013805","journal-title":"Nat Rev Genet"},{"key":"4_CR43_4","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1126\/science.7732380","volume":"268","author":"JK Ma","year":"1995","unstructured":"Ma JK, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, van Dolleweerd C, Mostov K, Lehner T (1995) Generation and assembly of secretory antibodies in plants. Science 268:716\u2013719","journal-title":"Science"},{"key":"4_CR44_4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nm0395-237","volume":"1","author":"R Malhotra","year":"1995","unstructured":"Malhotra R, Wormald MR, Rudd PM, Fischer PB, Dwek RA, Sim RB (1995) Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nat Med 1:237\u2013243","journal-title":"Nat Med"},{"key":"4_CR45_4","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nbt1094","volume":"23","author":"S Marillonnnet","year":"2005","unstructured":"Marillonnnet S, Thoeringer C, Kandzia R, Klimyuk V, Gleba Y (2005) Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants. Nat Biotechnol 23:718\u2013723","journal-title":"Nat Biotechnol"},{"key":"4_CR46_4","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.4049\/jimmunol.127.5.2188","volume":"127","author":"L Matusuuchi","year":"1981","unstructured":"Matusuuchi L, Sharon J, Morrison SL (1981) An analysis of heavy chain glycospeptides of hybri-doma antibodies: correlation between antibody specificity and sialic acid content. J Immunol 127:2188\u20132190","journal-title":"J Immunol"},{"key":"4_CR47_4","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1073\/pnas.0237108100","volume":"100","author":"SP Mayfield","year":"2003","unstructured":"Mayfield SP, Franklin SE, Lerner RA (2003) Expression and assembly of a fully active antibody in algae. Proc Natl Acad Sci USA 100:438\u2013442","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR48_4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4049\/jimmunol.166.10.6112","volume":"166","author":"AM McCall","year":"2001","unstructured":"McCall AM, Shahied L, Amoroso AR, Horak EM, Simmons HH, Nielson U, Adams GP, Schier R, Marks JD, Wiener LM (2001) Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity. J Immunol 166:112\u2013117","journal-title":"J Immunol"},{"key":"4_CR49_4","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1073\/pnas.96.2.703","volume":"96","author":"AA McCormick","year":"1999","unstructured":"McCormick AA, Kumagai MH, Hanley K, Turpen TH, Hakim I, Grill LK, Tuse D, Levy S, Levy R (1999) Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco. Proc Natl Acad Sci USA 96:703\u2013708","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR50_4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1365-313X.2004.02290.x","volume":"41","author":"S Miroshinichenko","year":"2005","unstructured":"Miroshinichenko S, Tripp J, Nieden U, Neumann D, Conrad U, Manteuffel R (2005) Immunomodulation of function of small heat shock proteins prevents their assembly into heat stress granules and results in cell death at sublethal temperatures. Plant J 41:269\u2013281","journal-title":"Plant J"},{"key":"4_CR51_4","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nm0605-593","volume":"11","author":"DC Montefiori","year":"2005","unstructured":"Montefiori DC (2005) Neutralizing antibodies take a swipe at HIV in vivo. Nat Med 11:593\u2013594","journal-title":"Nat Med"},{"key":"4_CR52_4","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI19361","volume":"112","author":"JD Nosanchuk","year":"2003","unstructured":"Nosanchuk JD, Steenbergen JN, Shi L, Deepe GSJ, Casadevall A (2003) Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum. J Clin Invest 112:1164\u20131175","journal-title":"J Clin Invest"},{"key":"4_CR53_4","doi-asserted-by":"publisher","first-page":"11346","DOI":"10.1073\/pnas.172229899","volume":"99","author":"A Nowakowski","year":"2002","unstructured":"Nowakowski A, Wang C, Powers DB, Amersdorfer P, Smith TJ, Montgomery VA, Sheridan R, Blake R, Smith LA, Marks JD (2002) Potent neutralization of botulinum neurotoxin by recom-binant oligoclonal antibody. Proc Natl Acad Sci USA 99:11346\u201311350","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR54_4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1467-7652.2005.00140.x","volume":"3","author":"J Nuttall","year":"2005","unstructured":"Nuttall J, Ma JK-C, Frigerio L (2005) A functional antibody lacking N-linked glycans is efficiently folded, assembled and secreted by tobacco mesophyll protoplasts. Plant Biotechnol J 3:497\u2013504","journal-title":"Plant Biotechnol J"},{"key":"4_CR55_4","first-page":"6042","volume":"269","author":"J Nuttall","year":"2002","unstructured":"Nuttall J, Vine ND, Hadlington JL, Drake P, Frigerio L, Ma JK-C (2002) ER-resident chaperone interactions with recombinant antibodies in transgenic plants. FEBS 269:6042\u20136051","journal-title":"FEBS"},{"key":"4_CR56_4","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1046\/j.1432-1327.2001.02340.x","volume":"268","author":"K Peeters","year":"2001","unstructured":"Peeters K, De Wilde C, Depicker A (2001) Highly efficient targeting and accumulation of a F(ab) fragment within the secretory pathway and apoplast of Arabidopsis thaliana. Eur J Biochem 268:4251\u20134260","journal-title":"Eur J Biochem"},{"key":"4_CR57_4","first-page":"30386","volume":"187","author":"M Prosniak","year":"2003","unstructured":"Prosniak M, Faber M, Hanlon CA, Rupprecht C, Hooper DC, Dietzschold B (2003) Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for post-exposure prophylaxis of rabies. J Infect Dis 187:30386\u201330389","journal-title":"J Infect Dis"},{"key":"4_CR58_4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0378-1119(95)00821-7","volume":"169","author":"R Schier","year":"1996","unstructured":"Schier R, Balint RF, McCall A, Apell G, Larrick JW, Marks JD (1996) Identification of functional and structural amino-acid residues by parsimonious mutagenesis. Gene 169:147\u2013155","journal-title":"Gene"},{"key":"4_CR59_4","doi-asserted-by":"crossref","unstructured":"Schiermeyer A, Dorfmuller S, Schinkel H (2004) Production of pharmaceutical proteins in plants and plant cell suspension cultures.","DOI":"10.1002\/3527603638.ch7"},{"key":"4_CR60_4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1008945126359","volume":"10","author":"S Schillberg","year":"2001","unstructured":"Schillberg S, Zimmermann S, Zhan M-Y, Fischer R (2001) Antibody-based resistance to plant pathogens. Transgenic Res 10:1\u201312","journal-title":"Transgenic Res"},{"key":"4_CR61_4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1006\/viro.1993.1015","volume":"192","author":"JJ Schlesinger","year":"1993","unstructured":"Schlesinger JJ, Foltzer M, Chapman S (1993) The Fc portion of antibody to yellow fever virus NS1 is a determinant of protection against YF encephalitis in mice. Virology 192:132\u2013141","journal-title":"Virology"},{"key":"4_CR62_4","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/0264-410X(92)90510-Q","volume":"10","author":"CL Schumacher","year":"1992","unstructured":"Schumacher CL, Ertl HC, Koprowski H, Dietzschold B (1992) Inhibition of immune responses against rabies virus by monoclonal antibodies directed against rabies virus antigens. Vaccine 10:754\u2013760","journal-title":"Vaccine"},{"key":"4_CR63_4","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/nbt1104-1351","volume":"22","author":"M Senveno","year":"2004","unstructured":"Senveno M, Bardor M, Paccalet T (2004) Glycoprotein sialylation in plants? Nat Biotechnol 22:1351\u20131352","journal-title":"Nat Biotechnol"},{"key":"4_CR64_4","first-page":"95","volume":"4","author":"JH Seon","year":"2002","unstructured":"Seon JH, Szarka S, Moloney M (2002) A unique strategy for recovering recombinant proteins from molecular farming: affinity capture on engineered oilbodies. J Plant Biotechnol 4:95\u2013101","journal-title":"J Plant Biotechnol"},{"key":"4_CR65_4","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/nbt912","volume":"21","author":"MM Shah","year":"2003","unstructured":"Shah MM, Fujiyama K, Flynn CR, Joshi L (2003) Presence of sialylated endogenous glyconju-gates in plant cells. Nat Biotechnol 21:1470\u20131471","journal-title":"Nat Biotechnol"},{"key":"4_CR66_4","doi-asserted-by":"publisher","first-page":"26733","DOI":"10.1074\/jbc.M202069200","volume":"277","author":"RL Shields","year":"2002","unstructured":"Shields RL, Lai J, Keck, R, O'Connell, L.Y, Hong, K, Meng, Y.G, Weikert, S.H.A, Presta, L (2002) Lack of Fucose on human IgG1 N-linked Oligosaccharide improves binding to human FcgRIII and antibody-dependent cellular toxicity. J Biol Chem 277:26733\u201326740","journal-title":"J Biol Chem"},{"key":"4_CR67_4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1071\/R96051","volume":"9","author":"G Smith","year":"1997","unstructured":"Smith G, Walmsley A, Polkinghorne I (1997) Plant-derived immunocontraceptive vaccines. Reprod Fertil Dev 9:85\u201389","journal-title":"Reprod Fertil Dev"},{"key":"4_CR68_4","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/nbt850","volume":"21","author":"WY Song","year":"2003","unstructured":"Song WY, Sohn EJ, Martinoia E, Lee YJ, Yang YY, Jasinski M, Forestier C, Hwang I, Lee Y (2003) Engineering tolerance and accumulation of lead and cadmium in transgenic plants. Nat Biotechnol 21:914\u2013919","journal-title":"Nat Biotechnol"},{"key":"4_CR69_4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0958-1669(02)00303-8","volume":"13","author":"E Stoger","year":"2002","unstructured":"Stoger E, Sack M, Fischer R, Christou P (2002) Plantibodies: applications, advantages and bottlenecks. Curr Opin Biotechnol 13:161\u2013166","journal-title":"Curr Opin Biotechnol"},{"key":"4_CR70_4","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.2174\/1381612054367535","volume":"11","author":"E Stoger","year":"2005","unstructured":"Stoger E, Sack M, Nicholson L, Fischer R, Christou P (2005) Recent progress in plantibody technology. Curr Pharmaceut Des 11:2439\u20132457","journal-title":"Curr Pharmaceut Des"},{"key":"4_CR71_4","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1023\/A:1006301519427","volume":"42","author":"E Stoger","year":"2000","unstructured":"Stoger E, Vaquero C, Torres E, Sack M, Nicholson L, Drossard J, Williams S, Keen D, Perrin Y, Christou P, Fischer R (2000) Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies. Plant Mol Biol 42:583\u2013590","journal-title":"Plant Mol Biol"},{"key":"4_CR72_4","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/0006-291X(92)92246-T","volume":"189","author":"H Tachibana","year":"1992","unstructured":"Tachibana H, Shirahata S, Murakami H (1992) Generation of specificity-variant antibodies by alteration of carbohydrate in light chain of human monoclonal antibodies. Biochem Biophys Res Commun 189:625\u2013632","journal-title":"Biochem Biophys Res Commun"},{"key":"4_CR73_4","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/nm1244","volume":"11","author":"A Trkola","year":"2005","unstructured":"Trkola A, Kuster H, Rusert P, Joos B, Fischer M, Leemann C, Manrique A, Huber M, Rehr M, Oxenius A, Weber R, Stiegler G, Vcelar B, Katinger H, Aceto L, Gunthard HF (2005) Delay of HIV-1 rebound after cessation of antiretoviral therapy through passive transfer of human neutralizing antibodies. Nat Med 11:615\u2013622","journal-title":"Nat Med"},{"key":"4_CR74_4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/6179","volume":"17","author":"P Umana","year":"1999","unstructured":"Umana P, Jean-Mairet J, Moudry R, Amstutz H, Bailey JE (1999) Engineered glycoforms of an antineuro-blastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity. Nat Biotechnol 17:176\u2013180","journal-title":"Nat Biotechnol"},{"key":"4_CR75_4","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/nbt1143","volume":"23","author":"C Vaccaro","year":"2005","unstructured":"Vaccaro C, Zhou J, Ober RJ, Ward E.S (2005) Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nat Biotechnol 23:1283\u20131288","journal-title":"Nat Biotechnol"},{"key":"4_CR76_4","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0006-291X(03)01335-4","volume":"308","author":"R Valdes","year":"2003","unstructured":"Valdes R, Gomez L, Padilla S, Brito J, Reyes B, Alvarez T, Mendoza O, Herrera O, Ferro W, Pujol M, Leal V, Linares M, Hevia Y, Garcia C, Mila L, Garcia O, Sanchez R, Acosta A, Geada D, Paez R, Luis Vega J, Borroto C (2003) Large-scale purification of an antibody directed against hepatitis B surface antigen from transgenic tobacco plants. Biochem Biophys Res Commun 308:94\u2013100","journal-title":"Biochem Biophys Res Commun"},{"key":"4_CR77_4","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1096\/fj.01-0363fje","volume":"16","author":"C Vaquero","year":"2002","unstructured":"Vaquero C, Sack M, Schuster F, Finnern R, Drossard J, Schumann D, Reimann A, Fischer R (2002) A carcinoembryonic antigen-specific diabody produced in tobacco. FASEB J 16:408\u2013410","journal-title":"FASEB J"},{"key":"4_CR78_4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0022-1759(98)00149-5","volume":"220","author":"T Verch","year":"1998","unstructured":"Verch T, Yusibov V, Koprowski H (1998) Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector. J Immunological Methods 220:69\u201375","journal-title":"J Immunological Methods"},{"key":"4_CR79_4","first-page":"5301","volume":"54","author":"ES Vietta","year":"1994","unstructured":"Vietta ES, Uhr JW (1994) Monoclonal antibodies as agonists: an expanded role for their use in cancer therapy. Cancer Res 54:5301\u20135309","journal-title":"Cancer Res"},{"key":"4_CR80_4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/BF01682088","volume":"1","author":"A Voss","year":"1995","unstructured":"Voss A, Niersbach M, Hain R, Hirsch HJ, Liao YC, Kreuzaler F, Fischer R (1995) Reduced virus infectivity in N. tabacum secreting a TMV-specific full-size antibody. Molecular Breeding 1:39\u201350","journal-title":"Molecular Breeding"},{"key":"4_CR81_4","first-page":"424","volume":"31","author":"TC Vrain","year":"1999","unstructured":"Vrain TC (1999) Engineering natural and synthetic resistance for nematode management. J Nematol 31:424\u2013436","journal-title":"J Nematol"},{"key":"4_CR82_4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1182\/blood.V83.4.899.899","volume":"83","author":"WM Vuist","year":"1994","unstructured":"Vuist WM, Levy R, Maloney DG (1994) Lymphoma regression induced by monoclonal anti-idi-otypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein. Blood 83:899\u2013906","journal-title":"Blood"},{"key":"4_CR83_4","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/nbt0505-556","volume":"23","author":"LM Weiner","year":"2005","unstructured":"Weiner LM, Carter P (2005) Tunable antibodies. Nat Biotechnol 23:556\u2013557","journal-title":"Nat Biotechnol"},{"key":"4_CR84_4","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1104\/pp.123.3.1097","volume":"123","author":"I Wenderoth","year":"2000","unstructured":"Wenderoth I, von Schaewen A (2000) Isolation and characterization of plant- N-acetyl glucosami-nyltransferase I (GntI) cDNA sequences. Functional analyses in the Arabidopsis cgl mutant and in antisense plants. Plant Physiol 123:1097\u20131108","journal-title":"Plant Physiol"},{"key":"4_CR85_4","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1146\/annurev.iy.12.040194.002245","volume":"12","author":"G Winter","year":"1994","unstructured":"Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR (1994) Making antibodies by phage display technology. Annu Rev Immunol 12:433\u2013455","journal-title":"Annu Rev Immunol"},{"key":"4_CR86_4","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.4049\/jimmunol.160.7.3393","volume":"160","author":"A Wright","year":"1998","unstructured":"Wright A, Morrison SL (1998) Effect of C2-associated carbohydrate structure on Ig effector function: studies with chimeric mouse-human IgG1 antibodies in glycosylation mutants of Chinese hamster ovary cells. J Immunol 160:3393\u20133402","journal-title":"J Immunol"},{"key":"4_CR87_4","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1002\/j.1460-2075.1991.tb07819.x","volume":"10","author":"A Wright","year":"1991","unstructured":"Wright A, Tao MH, Kabat EA, Morrison SL (1991) Antibody variable region glycosylation: position effects on antigen binding and carbohydrate structure. EMBO J 10:2717\u20132123","journal-title":"EMBO J"}],"container-title":["Current Topics in Microbiology and Immunology","Plant-produced Microbial Vaccines"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-540-70868-1_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T19:27:19Z","timestamp":1684956439000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-540-70868-1_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"ISBN":["9783540708575","9783540708681"],"references-count":87,"URL":"https:\/\/doi.org\/10.1007\/978-3-540-70868-1_4","relation":{},"ISSN":["0070-217X"],"issn-type":[{"value":"0070-217X","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}