{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T15:17:05Z","timestamp":1742397425635},"publisher-location":"Berlin, Heidelberg","reference-count":60,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783540712329"},{"type":"electronic","value":"9783540712336"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1007\/978-3-540-71233-6_14","type":"book-chapter","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:31:34Z","timestamp":1179707494000},"page":"168-184","source":"Crossref","is-referenced-by-count":1,"title":["Inverse Bifurcation Analysis of a Model for the Mammalian G 1\/S Regulatory Module"],"prefix":"10.1007","author":[{"given":"James","family":"Lu","sequence":"first","affiliation":[]},{"given":"Heinz W.","family":"Engl","sequence":"additional","affiliation":[]},{"given":"Rainer","family":"Machn\u00e9","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Schuster","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"issue":"2","key":"14_CR1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0955-0674(03)00017-6","volume":"15","author":"J.J. Tyson","year":"2003","unstructured":"Tyson, J.J., Chen, K.C., Novak, B.: Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr. Opin. Cell Biol.\u00a015(2), 221\u2013231 (2003)","journal-title":"Curr. Opin. Cell Biol."},{"issue":"Pt 4","key":"14_CR2","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1242\/jcs.106.4.1153","volume":"106","author":"B. Novak","year":"1993","unstructured":"Novak, B., Tyson, J.J.: Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos. J. Cell. Sci.\u00a0106 ( Pt 4), 1153\u20131168 (1993)","journal-title":"J. Cell. Sci."},{"issue":"3","key":"14_CR3","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1073\/pnas.0430083100","volume":"100","author":"M.J. Solomon","year":"2003","unstructured":"Solomon, M.J.: Hysteresis meets the cell cycle. Proc. Natl. Acad. Sci. U S A\u00a0100(3), 771\u2013772 (2003)","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"4","key":"14_CR4","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/ncb954","volume":"5","author":"J.R. Pomerening","year":"2003","unstructured":"Pomerening, J.R., Sontag, E.D.: Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat. Cell. Biol.\u00a05(4), 346\u2013351 (2003)","journal-title":"Nat. Cell. Biol."},{"issue":"4","key":"14_CR5","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.cell.2005.06.016","volume":"122","author":"J.R. Pomerening","year":"2005","unstructured":"Pomerening, J.R., Kim, S.Y.: Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell\u00a0122(4), 565\u2013578 (2005)","journal-title":"Cell"},{"issue":"12","key":"14_CR6","doi-asserted-by":"publisher","first-page":"4361","DOI":"10.1529\/biophysj.106.081240","volume":"90","author":"A. Csikasz-Nagy","year":"2006","unstructured":"Csikasz-Nagy, A., Battogtokh, D., Chen, K.C., Novak, B., Tyson, J.J.: Analysis of a generic model of eukaryotic cell-cycle regulation. Biophys. J.\u00a090(12), 4361\u20134379 (2006)","journal-title":"Biophys. J."},{"issue":"10","key":"14_CR7","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1093\/bioinformatics\/bth110","volume":"20","author":"M. Swat","year":"2004","unstructured":"Swat, M., Kel, A., Herzel, H.: Bifurcation analysis of the regulatory modules of the mammalian G1\/S transition. Bioinformatics\u00a020(10), 1506\u20131511 (2004)","journal-title":"Bioinformatics"},{"key":"14_CR8","unstructured":"Swat, M.J.: Bifurcation analysis of regulatory modules in cell biology. PhD dissertation, Humboldt-Universit\u00e4t Berlin (2005), http:\/\/edoc.hu-berlin.de\/dissertationen\/swat-maciej-2005-11-03\/PDF\/swat.pdf"},{"key":"14_CR9","unstructured":"SBML file of the mammalian G 1\/S regulatory module proposed by Swat et al. (2004), http:\/\/www.tbi.univie.ac.at\/~raim\/models\/swat04\/"},{"key":"14_CR10","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-3978-7","volume-title":"Elements of Applied Bifurcation Theory","author":"Y.A. Kuznetsov","year":"2004","unstructured":"Kuznetsov, Y.A.: Elements of Applied Bifurcation Theory. Springer, New York (2004)"},{"issue":"2 Pt 1","key":"14_CR11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1152\/ajpcell.1998.274.2.C531","volume":"274","author":"P. Smolen","year":"1998","unstructured":"Smolen, P., Baxter, D.A., Byrne, J.H.: Frequency selectivity, multistability, and oscillations emerge from models of genetic regulatory systems. Am. J. Physiol.\u00a0274(2 Pt 1), 531\u2013542 (1998)","journal-title":"Am. J. Physiol."},{"issue":"14","key":"14_CR12","doi-asserted-by":"publisher","first-page":"9364","DOI":"10.1073\/pnas.142284699","volume":"99","author":"T. Hofer","year":"2002","unstructured":"Hofer, T., Nathansen, H., Lohning, M., Radbruch, A., Heinrich, R.: GATA-3 transcriptional imprinting in Th2 lymphocytes: a mathematical model. Proc. Natl. Acad. Sci. U S A\u00a099(14), 9364\u20139368 (2002)","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"5","key":"14_CR13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nrm1365","volume":"5","author":"M.L. Coleman","year":"2004","unstructured":"Coleman, M.L., Marshall, C.J., Olson, M.F.: RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat. Rev. Mol. Cell Biol.\u00a05(5), 355\u2013366 (2004)","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"21","key":"14_CR14","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1007\/s00018-005-5083-6","volume":"62","author":"L. Santella","year":"2005","unstructured":"Santella, L., Ercolano, E., Nusco, G.A.: The cell cycle: a new entry in the field of Ca2+ signaling. Cell Mol. Life Sci.\u00a062(21), 2405\u20132413 (2005)","journal-title":"Cell Mol. Life Sci."},{"issue":"9","key":"14_CR15","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1002\/1521-1878(200009)22:9<818::AID-BIES7>3.0.CO;2-6","volume":"22","author":"K. Roovers","year":"2000","unstructured":"Roovers, K., Assoian, R.K.: Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays\u00a022(9), 818\u2013826 (2000)","journal-title":"Bioessays"},{"issue":"19","key":"14_CR16","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1038\/sj.onc.1204386","volume":"20","author":"F. Macian","year":"2001","unstructured":"Macian, F., Lopez-Rodriguez, C., Rao, A.: Partners in transcription: NFAT and AP-1. Oncogene\u00a020(19), 2476\u20132489 (2001)","journal-title":"Oncogene"},{"issue":"6","key":"14_CR17","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/S0092-8674(02)00767-5","volume":"109","author":"F. Macian","year":"2002","unstructured":"Macian, F., Garcia-Cozar, F., Im, S.H., Horton, H.F., Byrne, M.C., Rao, A.: Transcriptional mechanisms underlying lymphocyte tolerance. Cell\u00a0109(6), 719\u2013731 (2002)","journal-title":"Cell"},{"issue":"5","key":"14_CR18","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1046\/j.0014-2956.2001.02720.x","volume":"269","author":"S. Schuster","year":"2002","unstructured":"Schuster, S., Marhl, M., Hofer, T.: Modelling of simple and complex calcium oscillations. From single-cell responses to intercellular signalling. Eur. J. Biochem.\u00a0269(5), 1333\u20131355 (2002)","journal-title":"Eur. J. Biochem."},{"issue":"8","key":"14_CR19","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1038\/sj.emboj.7600197","volume":"23","author":"S.A. Walker","year":"2004","unstructured":"Walker, S.A., Kupzig, S., Bouyoucef, D., Davies, L.C., Tsuboi, T., Bivona, T.G., Cozier, G.E., Lockyer, P.J., Buckler, A., Rutter, G.A., Allen, M.J., Philips, M.R., Cullen, P.J.: Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. EMBO J.\u00a023(8), 1749\u20131760 (2004)","journal-title":"EMBO J."},{"issue":"6679","key":"14_CR20","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/31960","volume":"392","author":"R.E. Dolmetsch","year":"1998","unstructured":"Dolmetsch, R.E., Xu, K., Lewis, R.S.: Calcium oscillations increase the efficiency and specificity of gene expression. Nature\u00a0392(6679), 933\u2013936 (1998)","journal-title":"Nature"},{"issue":"6679","key":"14_CR21","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/31965","volume":"392","author":"W. Li","year":"1998","unstructured":"Li, W., Llopis, J., Whitney, M., Zlokarnik, G., Tsien, R.Y.: Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature\u00a0392(6679), 936\u2013941 (1998)","journal-title":"Nature"},{"issue":"3","key":"14_CR22","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0092-8674(95)90430-1","volume":"82","author":"G. Hajnoczky","year":"1995","unstructured":"Hajnoczky, G., Robb-Gaspers, L.D., Seitz, M.B., Thomas, A.P.: Decoding of cytosolic calcium oscillations in the mitochondria. Cell\u00a082(3), 415\u2013424 (1995)","journal-title":"Cell"},{"issue":"6","key":"14_CR23","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0143-4160(03)00152-0","volume":"34","author":"P.G. Dupont","year":"2003","unstructured":"Dupont, P.G., Houart, G., De Koninck, P.: Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: a simple model. Cell Calcium\u00a034(6), 485\u2013497 (2003)","journal-title":"Cell Calcium"},{"issue":"15","key":"14_CR24","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.1093\/emboj\/cdg381","volume":"22","author":"T. Tomida","year":"2003","unstructured":"Tomida, T., Hirose, K., Takizawa, A., Shibasaki, F., Iino, M.: NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J.\u00a022(15), 3825\u20133832 (2003)","journal-title":"EMBO J."},{"issue":"3-4","key":"14_CR25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0248-4900(00)01068-6","volume":"92","author":"V.L. Nixon","year":"2000","unstructured":"Nixon, V.L., McDougall, A., Jones, K.T.: Ca2+ oscillations and the cell cycle at fertilisation of mammalian and ascidian eggs. Biol. Cell\u00a092(3-4), 187\u2013196 (2000)","journal-title":"Biol. Cell"},{"issue":"2","key":"14_CR26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","volume":"80","author":"C.J. Marshall","year":"1995","unstructured":"Marshall, C.J.: Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell\u00a080(2), 179\u2013185 (1995)","journal-title":"Cell"},{"issue":"8","key":"14_CR27","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/ncb822","volume":"4","author":"L.O. Murphy","year":"2002","unstructured":"Murphy, L.O., Smith, S., Chen, R.H., Fingar, D.C., Blenis, J.: Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol.\u00a04(8), 556\u2013564 (2002)","journal-title":"Nat. Cell Biol."},{"issue":"19","key":"14_CR28","doi-asserted-by":"publisher","first-page":"10078","DOI":"10.1073\/pnas.93.19.10078","volume":"93","author":"C.Y. Huang","year":"1996","unstructured":"Huang, C.Y.: Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U S A\u00a093(19), 10078\u201310083 (1996)","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"5365","key":"14_CR29","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1126\/science.280.5365.895","volume":"280","author":"J.E. Ferrell Jr.","year":"1998","unstructured":"Ferrell Jr., J.E., Machleder, E.M.: The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science\u00a0280(5365), 895\u2013898 (1998)","journal-title":"Science"},{"issue":"3","key":"14_CR30","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/ni895","volume":"4","author":"I. Stefanova","year":"2003","unstructured":"Stefanova, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W.E., Germain, R.N.: TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat. Immunol.\u00a04(3), 248\u2013254 (2003)","journal-title":"Nat. Immunol."},{"issue":"6858","key":"14_CR31","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/35101500","volume":"413","author":"J.B. Gurdon","year":"2001","unstructured":"Gurdon, J.B., Bourillot, P.Y.: Morphogen gradient interpretation. Nature\u00a0413(6858), 797\u2013803 (2001)","journal-title":"Nature"},{"issue":"1","key":"14_CR32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nrm715","volume":"3","author":"C.A. Hazzalin","year":"2002","unstructured":"Hazzalin, C.A., Mahadevan, L.C.: MAPK-regulated transcription: a continuously variable gene switch? Nat. Rev. Mol. Cell. Biol.\u00a03(1), 30\u201340 (2002)","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"3","key":"14_CR33","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1083\/jcb.200308060","volume":"164","author":"N.I. Markevich","year":"2004","unstructured":"Markevich, N.I., Hoek, J.B., Kholodenko, B.N.: Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J. Cell Biol.\u00a0164(3), 353\u2013359 (2004)","journal-title":"J. Cell Biol."},{"issue":"1","key":"14_CR34","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1432-1033.2004.04404.x","volume":"272","author":"J.J. Hornberg","year":"2005","unstructured":"Hornberg, J.J., Bruggeman, F.J., Binder, B., Geest, C.R., de Vaate, A.J., Lankelma, J., Heinrich, R., Westerhoff, H.V.: Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase\/phosphatase control. FEBS J.\u00a0272(1), 244\u2013258 (2005)","journal-title":"FEBS J."},{"issue":"5583","key":"14_CR35","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1126\/science.1068873","volume":"297","author":"U.S. Bhalla","year":"2002","unstructured":"Bhalla, U.S., Ram, P.T., Iyengar, R.: MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science\u00a0297(5583), 1018\u20131023 (2002)","journal-title":"Science"},{"key":"14_CR36","doi-asserted-by":"crossref","unstructured":"Lu, J., Engl, H.W., Schuster, P.: Inverse bifurcation analysis: application to simple gene systems. Algorithms for Molecular Biology\u00a01(11) (2006)","DOI":"10.1186\/1748-7188-1-11"},{"key":"14_CR37","unstructured":"Conrad, E.: Bifurcation analysis and qualitative optimization of models in molecular cell biology with applications to the circadian clock. PhD dissertation, Virginia Polytechnic Institute and State University (2006), http:\/\/scholar.lib.vt.edu\/theses\/available\/etd-04272006-1104%09\/unrestricted\/phd_20060510.pdf"},{"issue":"3","key":"14_CR38","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/BF02429868","volume":"3","author":"I. Dobson","year":"1993","unstructured":"Dobson, I.: Computing a closest bifurcation instability in multidimensional parameter space. J. Nonlinear Sci.\u00a03(3), 307\u2013327 (1993)","journal-title":"J. Nonlinear Sci."},{"issue":"2","key":"14_CR39","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00332-001-0400-1","volume":"12","author":"M. M\u00f6nnigmann","year":"2002","unstructured":"M\u00f6nnigmann, M., Marquardt, W.: Normal vectors on manifolds of critical points for parametric robustness of equilibrium solutions of ODE systems. J. Nonlinear Sci.\u00a012(2), 85\u2013112 (2002)","journal-title":"J. Nonlinear Sci."},{"issue":"1","key":"14_CR40","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1049\/sb:20045015","volume":"1","author":"H. Schmidt","year":"2004","unstructured":"Schmidt, H., Jacobsen, E.W.: Linear systems approach to analysis of complex dynamic behaviours in biochemical networks. Systems Biology\u00a01(1), 149\u2013158 (2004)","journal-title":"Systems Biology"},{"issue":"3","key":"14_CR41","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1177\/0748730406287357","volume":"21","author":"P. Indic","year":"2006","unstructured":"Indic, P., Gurdziel, K., Kronauer, R.E., Klerman, E.B.: Development of a two-dimensional manifold to represent high dimension mathematical models of the intracellular mammalian circadian clock. Journal of Biological Rhythms\u00a021(3), 222\u2013232 (2006)","journal-title":"Journal of Biological Rhythms"},{"key":"14_CR42","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ymben.2003.11.003","volume":"6","author":"Z.P. Gerdtzen","year":"2004","unstructured":"Gerdtzen, Z.P., Daoutidis, P., Hu, W.-S.: Non-linear reduction for kinetic models of metabolic reaction networks. Metabolic Engineering\u00a06, 140\u2013154 (2004)","journal-title":"Metabolic Engineering"},{"key":"14_CR43","series-title":"Mathematics and its Applications","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/978-94-009-1740-8","volume-title":"Regularization of inverse problems","author":"H.W. Engl","year":"1996","unstructured":"Engl, H.W., Hanke, M., Neubauer, A.: Regularization of inverse problems. Mathematics and its Applications, vol.\u00a0375, p. 321. Kluwer Academic Publishers Group, Dordrecht (1996)"},{"issue":"5","key":"14_CR44","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1073\/pnas.0437847100","volume":"100","author":"D.L. Donoho","year":"2003","unstructured":"Donoho, D.L., Elad, M.: Optimally sparse representation in general (nonorthogonal) dictionaries via $l\\sp 1$ minimization. Proc. Natl. Acad. Sci. USA\u00a0100(5), 2197\u20132202 (electronic) (2003)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"14_CR45","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/cpa.20042","volume":"57","author":"I. Daubechies","year":"2004","unstructured":"Daubechies, I., Defrise, M., De Mol, C.: An iterative thresholding algorithm for linear inverse problems with a sparsity constraint. Comm. Pure Appl. Math.\u00a057(11), 1413\u20131457 (2004)","journal-title":"Comm. Pure Appl. Math."},{"issue":"5","key":"14_CR46","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1088\/0266-5611\/21\/5\/005","volume":"21","author":"R. Ramlau","year":"2005","unstructured":"Ramlau, R., Teschke, G.: Tikhonov replacement functionals for iteratively solving nonlinear operator equations. Inverse Problems\u00a021(5), 1571\u20131592 (2005)","journal-title":"Inverse Problems"},{"key":"14_CR47","volume-title":"Practical Optimization","author":"P.E. Gill","year":"1981","unstructured":"Gill, P.E., Murray, W., Wright, M.H.: Practical Optimization. Academic Press, London (1981)"},{"key":"14_CR48","series-title":"MPS-SIAM Series on Optimization","doi-asserted-by":"crossref","DOI":"10.1137\/1.9780898719857","volume-title":"Trust-Region Methods","author":"A.T. Conn","year":"2000","unstructured":"Conn, A.T., Gould, N.I.M., Toint, P.L.: Trust-Region Methods. MPS-SIAM Series on Optimization. SIAM, Philadelphia (2000)"},{"key":"14_CR49","unstructured":"MATLAB. http:\/\/www.mathworks.com\/products\/matlab\/"},{"issue":"2","key":"14_CR50","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1145\/779359.779362","volume":"29","author":"A. Dhooge","year":"2003","unstructured":"Dhooge, A., Govaerts, W., Kuznetsov, Y.A.: MATCONT: a MATLAB package for numerical bifurcation analysis of ODEs. ACM Trans. Math. Software\u00a029(2), 141\u2013164 (2003)","journal-title":"ACM Trans. Math. Software"},{"key":"14_CR51","unstructured":"MATCONT: continuation software in MATLAB, http:\/\/www.matcont.ugent.be\/"},{"key":"14_CR52","unstructured":"Systems Biology Markup Language, http:\/\/sbml.org\/"},{"key":"14_CR53","unstructured":"Mathematica, http:\/\/www.wolfram.com\/products\/mathematica\/"},{"key":"14_CR54","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1093\/bioinformatics\/bth271","volume":"20","author":"B.E. Shapiro","year":"2004","unstructured":"Shapiro, B.E., Hucka, M., Finney, A., Doyle, J.: MathSBML: a package for manipulating SBML-based biological models. Bioinformatics\u00a020, 2829\u20132831 (2004)","journal-title":"Bioinformatics"},{"issue":"3","key":"14_CR55","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/ar.10165","volume":"268","author":"J.M. Perez-Pomares","year":"2002","unstructured":"Perez-Pomares, J.M., Munoz-Chapuli, R.: Epithelial-mesenchymal transitions: a mesodermal cell strategy for evolutive innovation in Metazoans. Anat. Rec.\u00a0268(3), 343\u2013351 (2002)","journal-title":"Anat. Rec."},{"issue":"5","key":"14_CR56","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.gde.2005.07.001","volume":"15","author":"M. Korenjak","year":"2005","unstructured":"Korenjak, M., Brehm, A.: E2F-Rb complexes regulating transcription of genes important for differentiation and development. Curr. Opin. Genet. Dev.\u00a015(5), 520\u2013527 (2005)","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"5","key":"14_CR57","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s10495-006-5543-y","volume":"11","author":"N. Godefroy","year":"2006","unstructured":"Godefroy, N., Lemaire, C., Mignotte, B., Vayssiere, J.L.: p53 and Retinoblastoma protein (pRb): a complex network of interactions. Apoptosis\u00a011(5), 659\u2013661 (2006)","journal-title":"Apoptosis"},{"issue":"21","key":"14_CR58","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1038\/sj.onc.1208372","volume":"24","author":"C.F. Wong","year":"2005","unstructured":"Wong, C.F., Barnes, L.M., Dahler, A.L., Smith, L., Popa, C., Serewko-Auret, M.M., Saunders, N.A.: E2F suppression and Sp1 overexpression are sufficient to induce the differentiation-specific marker, transglutaminase type 1, in a squamous cell carcinoma cell line. Oncogene\u00a024(21), 3525\u20133534 (2005)","journal-title":"Oncogene"},{"issue":"1","key":"14_CR59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.molcel.2005.10.035","volume":"21","author":"J.M. Bean","year":"2006","unstructured":"Bean, J.M., Siggia, E.D., Cross, F.R.: Coherence and timing of cell cycle start examined at single-cell resolution. Mol. Cell\u00a021(1), 3\u201314 (2006)","journal-title":"Mol. Cell"},{"key":"14_CR60","doi-asserted-by":"crossref","unstructured":"Ubersax, J.A.: A noisy \u2019Start\u2019 to the cell cycle. Mol. Syst. Biol.\u00a02, 2006.0014 (2006)","DOI":"10.1038\/msb4100056"}],"container-title":["Lecture Notes in Computer Science","Bioinformatics Research and Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-540-71233-6_14.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:32:01Z","timestamp":1628901121000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-540-71233-6_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[null]]},"ISBN":["9783540712329","9783540712336"],"references-count":60,"URL":"https:\/\/doi.org\/10.1007\/978-3-540-71233-6_14","relation":{},"subject":[]}}