{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:38:44Z","timestamp":1768347524402,"version":"3.49.0"},"publisher-location":"Berlin, Heidelberg","reference-count":25,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540717829","type":"print"},{"value":"9783540717836","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1007\/978-3-540-71783-6_16","type":"book-chapter","created":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T07:45:57Z","timestamp":1182325557000},"page":"166-175","source":"Crossref","is-referenced-by-count":115,"title":["Tuning ReliefF for Genome-Wide Genetic Analysis"],"prefix":"10.1007","author":[{"given":"Jason H.","family":"Moore","sequence":"first","affiliation":[]},{"given":"Bill C.","family":"White","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"16_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrg1521","volume":"6","author":"J.N. Hirschhorn","year":"2005","unstructured":"Hirschhorn, J.N., Daly, M.J.: Genome-wide association studies for common diseases and complex traits. Nature Reviews Genetics\u00a06, 95\u2013108 (2005)","journal-title":"Nature Reviews Genetics"},{"key":"16_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrg1522","volume":"6","author":"W.Y. Wang","year":"2005","unstructured":"Wang, W.Y., Barratt, B.J., Clayton, D.G., Todd, J.A.: Genome-wide association studies: Theoretical and practical concerns. Nature Reviews Genetics\u00a06, 109\u2013118 (2005)","journal-title":"Nature Reviews Genetics"},{"key":"16_CR3","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.44575","volume-title":"Mendel\u2019s Principles of Heredity","author":"W. Bateson","year":"1909","unstructured":"Bateson, W.: Mendel\u2019s Principles of Heredity. Cambridge University Press, Cambridge (1909)"},{"key":"16_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000073735","volume":"56","author":"J.H. Moore","year":"2003","unstructured":"Moore, J.H.: The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Human Heredity\u00a056, 73\u201382 (2003)","journal-title":"Human Heredity"},{"key":"16_CR5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/bies.20236","volume":"27","author":"J.H. Moore","year":"2005","unstructured":"Moore, J.H., Williams, S.W.: Traversing the conceptual divide between biological and statistical epistasis: Systems biology and a more modern synthesis. BioEssays\u00a027, 637\u2013646 (2005)","journal-title":"BioEssays"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.tig.2004.09.007","volume":"20","author":"T.A. Thornton-Wells","year":"2004","unstructured":"Thornton-Wells, T.A., Moore, J.H., Haines, J.L.: Genetics, statistics and human disease: Analytical retooling for complexity. Trends in Genetics\u00a020, 640\u2013647 (2004)","journal-title":"Trends in Genetics"},{"key":"16_CR7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1023\/A:1011996210207","volume":"16","author":"A. Freitas","year":"2001","unstructured":"Freitas, A.: Understanding the crucial role of attribute interactions. Artificial Intelligence Review\u00a016, 177\u2013199 (2001)","journal-title":"Artificial Intelligence Review"},{"key":"16_CR8","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1159\/000022939","volume":"50","author":"W. Li","year":"2000","unstructured":"Li, W., Reich, J.: A complete enumeration and classification of two-locus disease models. Human Heredity\u00a050, 334\u2013349 (2000)","journal-title":"Human Heredity"},{"key":"16_CR9","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1001\/jama.291.13.1642","volume":"291","author":"J.H. Moore","year":"2004","unstructured":"Moore, J.H., Ritchie, M.D.: The challenges of whole-genome approaches to common diseases. JAMA\u00a0291, 1642\u20131643 (2004)","journal-title":"JAMA"},{"key":"16_CR10","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1080\/07853890252953473","volume":"34","author":"J.H. Moore","year":"2002","unstructured":"Moore, J.H., Williams, S.W.: New strategies for identifying gene-gene interactions in hypertension. Annals of Medicine\u00a034, 88\u201395 (2002)","journal-title":"Annals of Medicine"},{"key":"16_CR11","doi-asserted-by":"crossref","unstructured":"Kira, K., Rendell, L.A.: A practical approach to feature selection. In: Machine Learning: Proceedings of the AAAI\u201992 (1992)","DOI":"10.1016\/B978-1-55860-247-2.50037-1"},{"key":"16_CR12","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/3-540-57868-4_57","volume-title":"Machine Learning: ECML-94","author":"I. Kononenko","year":"1994","unstructured":"Kononenko, I.: Estimating attributes: Analysis and extension of relief. In: Bergadano, F., De Raedt, L. (eds.) ECML 1994. LNCS, vol.\u00a0784, pp. 171\u2013182. Springer, Heidelberg (1994)"},{"key":"16_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1023\/A:1025667309714","volume":"53","author":"M. Robnik-Sikonja","year":"2003","unstructured":"Robnik-Sikonja, M., Kononenko, I.: Theoretical and empirical analysis of relieff and rrelieff. Machine Learning\u00a053, 23\u201369 (2003)","journal-title":"Machine Learning"},{"key":"16_CR14","unstructured":"Robnik-Sikonja, M., Kononenko, I.: Comprehensible interpretation of relief\u2019s estimates. In: Proceedings of the Eighteenth International Conference on Machine Learning, pp. 433\u2013440 (2001)"},{"key":"16_CR15","first-page":"183","volume":"4","author":"L.W. Hahn","year":"2004","unstructured":"Hahn, L.W., Moore, J.H.: Ideal discrimination of discrete clinical endpoints using multilocus genotypes. Silico Biology\u00a04, 183\u2013194 (2004)","journal-title":"Silico Biology"},{"key":"16_CR16","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/bioinformatics\/btf869","volume":"19","author":"L.W. Hahn","year":"2003","unstructured":"Hahn, L.W., Ritchie, M.D., Moore, J.H.: Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics\u00a019, 376\u2013382 (2003)","journal-title":"Bioinformatics"},{"key":"16_CR17","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1586\/14737159.4.6.795","volume":"4","author":"J.H. Moore","year":"2004","unstructured":"Moore, J.H.: Computational analysis of gene-gene interactions in common human diseases using multifactor dimensionality reduction. Expert Review of Molecular Diagnostics\u00a04, 795\u2013803 (2004)","journal-title":"Expert Review of Molecular Diagnostics"},{"key":"16_CR18","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jtbi.2005.11.036","volume":"241","author":"J.H. Moore","year":"2006","unstructured":"Moore, J.H., Gilbert, J.C., Tsai, C., Chiang, F.T., Holden, W., Barney, N., White, B.C.: A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. Journal of Theoretical Biology\u00a0241, 252\u2013261 (2006)","journal-title":"Journal of Theoretical Biology"},{"key":"16_CR19","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/gepi.10218","volume":"24","author":"M.D. Ritchie","year":"2003","unstructured":"Ritchie, M.D., Hahn, L.W., Moore, J.H.: Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, phenocopy, and genetic heterogeneity. Genetic Epidemiology\u00a024, 150\u2013157 (2003)","journal-title":"Genetic Epidemiology"},{"key":"16_CR20","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1086\/321276","volume":"69","author":"M.D. Ritchie","year":"2001","unstructured":"Ritchie, M.D., Hahn, L.W., Roodi, N., Bailey, L.R., Dupont, W.D., Parl, F.F., Moore, J.H.: Multifactor dimensionality reduction reveals high-order interactions among estrogen metabolism genes in sporadic breast cancer. American Journal of Human Genetics\u00a069, 138\u2013147 (2001)","journal-title":"American Journal of Human Genetics"},{"key":"16_CR21","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/11844297_98","volume-title":"Parallel Problem Solving from Nature - PPSN IX","author":"J.H. Moore","year":"2006","unstructured":"Moore, J.H., White, B.C.: Exploiting expert knowledge in genetic programming for genome-wide genetic analysis. In: Runarsson, T.P., Beyer, H.-G., Burke, E.K., Merelo-Guerv\u00f3s, J.J., Whitley, L.D., Yao, X. (eds.) PPSN 2006. LNCS, vol.\u00a04193, pp. 969\u2013977. Springer, Heidelberg (2006)"},{"key":"16_CR22","doi-asserted-by":"crossref","unstructured":"Moore, J.H.: Genome-wide analysis of epistasis using multifactor dimensionality reduction: feature selection and construction in the domain of human genetics. In: Knowledge Discovery and Data Mining: Challenges and Realities with Real World Data. IGI (2007)","DOI":"10.4018\/978-1-59904-252-7.ch002"},{"key":"16_CR23","volume-title":"Genetic Programming Theory and Practice","author":"J.H. Moore","year":"2007","unstructured":"Moore, J.H., White, B.C.: Genome-wide genetic analysis using genetic programming: The critical need for expert knowledge. In: Genetic Programming Theory and Practice, vol.\u00a04, Springer, Heidelberg (2007)"},{"key":"16_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.artint.2004.05.009","volume":"159","author":"H. Lui","year":"2004","unstructured":"Lui, H., Motoda, H., Yu, L.: A selective sampling approach to active feature selection. Artificial Intelligence\u00a0159, 49\u201374 (2004)","journal-title":"Artificial Intelligence"},{"key":"16_CR25","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1093\/bioinformatics\/bth261","volume":"20","author":"E. Frank","year":"2004","unstructured":"Frank, E., Hall, M., Trigg, L., Holmes, G., Witten, L.: Data mining in bioinformatics using weka. Bioinformatics\u00a020, 2479\u20132481 (2004)","journal-title":"Bioinformatics"}],"container-title":["Lecture Notes in Computer Science","Evolutionary Computation,Machine Learning and Data Mining in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-540-71783-6_16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T05:26:08Z","timestamp":1605763568000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-540-71783-6_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[null]]},"ISBN":["9783540717829","9783540717836"],"references-count":25,"URL":"https:\/\/doi.org\/10.1007\/978-3-540-71783-6_16","relation":{},"subject":[]}}