{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:59:51Z","timestamp":1790884791134,"version":"4.1.0"},"publisher-location":"Berlin, Heidelberg","reference-count":197,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540790891","type":"print"},{"value":"9783540790907","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"DOI":"10.1007\/978-3-540-79090-7_6","type":"book-chapter","created":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T16:35:28Z","timestamp":1249403728000},"page":"185-225","source":"Crossref","is-referenced-by-count":56,"title":["Regulation of Cardiac Afferent Excitability in Ischemia"],"prefix":"10.1007","author":[{"given":"Liang-Wu","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Longhurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,6,10]]},"reference":[{"key":"6_CR1_6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0028-3908(95)00136-0","volume":"35","author":"FV Abbott","year":"1996","unstructured":"Abbott FV, Hong Y, Blier P (1996) Activation of 5-HT2A receptors potentiates pain produced by inflammatory mediators. Neuropharmacology 35:99\u2013110","journal-title":"Neuropharmacology"},{"key":"6_CR2_6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0165-1838(98)00060-5","volume":"71","author":"T Abe","year":"1998","unstructured":"Abe T, Morgan D, Sengupta JN, Gebhart GF, Gutterman DD (1998) Attenuation of ischemia-induced activation of cardiac sympathetic afferents following brief myocardial ischemia in cats. J Auton Nerv Syst 71:28\u201336","journal-title":"J Auton Nerv Syst"},{"key":"6_CR3_6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1152\/jn.1994.72.2.684","volume":"72","author":"SC Ahlgren","year":"1994","unstructured":"Ahlgren SC, Levine JD (1994) Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat. J Neurophysiol 72:684\u2013692","journal-title":"J Neurophysiol"},{"issue":"3","key":"6_CR4_6","first-page":"185","volume":"33","author":"H Aizawa","year":"1988","unstructured":"Aizawa H, Hirose T (1988) A possible mechanism of airway hyperresponsiveness induced by prostaglandin F2 alpha and thromooxane A2. Prosaglandins Leukot Essent Fatty Acids 33(3):185\u2013189","journal-title":"Prosaglandins Leukot Essent Fatty Acids"},{"key":"6_CR5_6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1699-0463.1967.tb01322.x","volume":"70","author":"NE Anden","year":"1967","unstructured":"Anden NE, Olsson Y (1967) 5-hydroxytryptamine in normal and sectioned rat sciatic nerve. Acta Pathol Microbiol Scand 70:537\u2013540","journal-title":"Acta Pathol Microbiol Scand"},{"key":"6_CR6_6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0163-7827(89)90002-7","volume":"28","author":"H Arita","year":"1989","unstructured":"Arita H, Nakano T, Hanasaki K (1989) Thromboxane A2: its generation and role in platelet activation. Prog Lipid Res 28:273\u2013301","journal-title":"Prog Lipid Res"},{"key":"6_CR7_6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1113\/jphysiol.1951.sp004686","volume":"115","author":"D Armstrong","year":"1951","unstructured":"Armstrong D, Dry RM, Keele CA, Markham JW (1951) Method for studying chemical excitants of cutaneous pain in man. J Physiol 115:59\u201360","journal-title":"J Physiol"},{"key":"6_CR8_6","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/01.CIR.73.3.572","volume":"73","author":"JH Ashton","year":"1986","unstructured":"Ashton JH, Benedict CR, Fitzgerald C, Raheja S, Taylor A, Campbell WB, Buja LM, Willerson JT (1986) Serotonin as a mediator of cyclic flow variation in stenosed canine coronoary arteries. Circulation 73:572\u2013578","journal-title":"Circulation"},{"key":"6_CR9_6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/jphysiol.1980.sp013412","volume":"306","author":"D Baker","year":"1980","unstructured":"Baker D, Coleridge H, Coleridge J, Nerdrum T (1980) Search for a cardiac nociceptor: Stimulation by bradykinin of sympathetic afferent nerve endings in the heart of the cat. J Physiol 306:519\u2013536","journal-title":"J Physiol"},{"key":"6_CR10_6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1113\/jphysiol.1979.sp013040","volume":"297","author":"JS Belville","year":"1979","unstructured":"Belville JS, Bennett WF, Lynch G (1979) A method for investigating the role of calcium in the shape change, aggregation and secretion of rat platelets. J Physiol 297:289\u2013297","journal-title":"J Physiol"},{"key":"6_CR11_6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/01.RES.58.1.58","volume":"58","author":"CR Benedict","year":"1986","unstructured":"Benedict CR, Mathew B, Rex KA, Cartwright J, Sordahl LA (1986) Correlation of plasma serotonin changes with platelet aggregation in an in vivo dog model of spontaneous occlusive coronary thrombus formation. Circ Res 58:58\u201367","journal-title":"Circ Res"},{"key":"6_CR12_6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0002-9149(77)80154-9","volume":"39","author":"HJ Berger","year":"1977","unstructured":"Berger HJ, Zaret BL, Speroff L, Cohen LS, Wolfson S (1977) Cardiac prostaglandin release during myocardial ischemia induced by atrial pacing in patients with coronary artery disease. Am J Cardiol 39:481\u2013486","journal-title":"Am J Cardiol"},{"key":"6_CR13_6","first-page":"298","volume-title":"Neurobiology of Nociceptors","author":"S Bevan","year":"1996","unstructured":"Bevan S (1996) Intracellular messengers and signal transduction in nociceptors. In: Belmonte C, Cervero F (eds) Neurobiology of Nociceptors. Oxford University Press, Oxford, pp 298\u2013324"},{"key":"6_CR14_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)00058-4","volume":"44","author":"KD Bhoola","year":"1992","unstructured":"Bhoola KD, Figueroa CD, Worthy K (1992) Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol Rev 44:1\u201380","journal-title":"Pharmacol Rev"},{"key":"6_CR15_6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1074\/jbc.273.1.475","volume":"273","author":"SC Blackman","year":"1998","unstructured":"Blackman SC, Dawson G, Antonakis K, Le Breton GC (1998) The identification and characterization of oligodendrocyte thromboxane A2 receptors. J Biol Chem 273:475\u2013483","journal-title":"J Biol Chem"},{"key":"6_CR16_6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1090-3801(99)90052-6","volume":"3","author":"J Blunk","year":"1999","unstructured":"Blunk J, Osiander G, Nischik M, Schmelz M (1999) Pain and inflammatory hyperalgesia induced by intradermal injections of human platelets and leukocytes. Eur J Pain 3:247\u2013259","journal-title":"Eur J Pain"},{"key":"6_CR17_6","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1016\/S0021-9258(17)37576-2","volume":"269","author":"C Borg","year":"1994","unstructured":"Borg C, Lim CT, Yeomans DC, Dieter JP, Komiotis D, Anderson EG, Le Breton GC (1994) Purification of rat brain, rabbit aorta, and human platelet thromboxane A2\/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies. J Biol Chem 269:6109\u20136116","journal-title":"J Biol Chem"},{"key":"6_CR18_6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1469-7793.1999.00517.x","volume":"2","author":"AM Brunsden","year":"1999","unstructured":"Brunsden AM, Grundy D (1999) Sensitization of visceral afferents to bradykinin in rat jejunum in vitro. J Physiol 521 Pt 2:517\u2013527","journal-title":"J Physiol 521 Pt"},{"key":"6_CR19_6","first-page":"R321","volume":"266","author":"JA Carrithers","year":"1994","unstructured":"Carrithers JA, Liu F, Shirer HW, Orr JA (1994) Mechanisms for techypneic response to the thromboxane A2 memetic U-46,619 in rabbits. Am J Physiol 266:R321\u2013R327","journal-title":"Am J Physiol"},{"key":"6_CR20_6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-6997(25)06784-5","volume":"46","author":"RA Coleman","year":"1994","unstructured":"Coleman RA, Smith WL, Narumiya S (1994) VIII. International union of pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46:205\u2013229","journal-title":"Pharmacol Rev"},{"key":"6_CR21_6","first-page":"S57","volume":"100","author":"BS Coller","year":"1997","unstructured":"Coller BS (1997) Platelet GPIIb\/IIIa antagonists: the first anti-integrin receptor therapeutics. J Clin Invest 100:S57\u2013S60","journal-title":"J Clin Invest"},{"key":"6_CR22_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-2999(01)01318-8","volume":"429","author":"R Couture","year":"2001","unstructured":"Couture R, Harrisson M, Vianna RM, Cloutier F (2001) Kinin receptors in pain and inflammation. Eur J Pharmacol 429:167\u2013176","journal-title":"Eur J Pharmacol"},{"key":"6_CR23_6","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1172\/JCI114203","volume":"84","author":"DA Cox","year":"1989","unstructured":"Cox DA, Vita JA, Treasure CB, Fish RD, Seiwyn AP, Ganz P (1989) Reflex increase in blood pressure during intra-coronary administration of adenosine in man. J Clin Invest 84:592\u2013596","journal-title":"J Clin Invest"},{"key":"6_CR24_6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/01.CIR.81.1.164","volume":"81","author":"F Crea","year":"1990","unstructured":"Crea F, Pupita G, Galassi A, El-Tamimi H, Kaski JC, Davis G, Maseri A (1990) Role of adenosine in pathogenesis of angina pain. Circulation 81:164\u2013182","journal-title":"Circulation"},{"key":"6_CR25_6","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/0735-1097(92)90442-P","volume":"20","author":"F Crea","year":"1992","unstructured":"Crea F, Gaspardone A, Kaski JC, Davis G, Maseri A (1992) Relation between stimulation site of cardiac afferent nerves by adenosine and distribution of cardiac pain: results of a study in patients with stable angina. JACC 20:1498\u20131502","journal-title":"JACC"},{"key":"6_CR26_6","first-page":"H1019","volume":"226","author":"JA Delyani","year":"1994","unstructured":"Delyani JA, Van Wylen GL (1994) Endocardial and epicardial interstitial purines and lactate during graded ischemia. Am J Physiol 226:H1019\u2013H1026","journal-title":"Am J Physiol"},{"key":"6_CR27_6","first-page":"H395","volume":"265","author":"ME Dibner-Dunlap","year":"1993","unstructured":"Dibner-Dunlap ME, Kinugawa T, Thames MD (1993) Activation of cardiac sympathetic afferents: effects of exogenous adenosine and adenosine analogues. Am J Physiol 265:H395\u2013H400","journal-title":"Am J Physiol"},{"key":"6_CR28_6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/bja\/75.2.125","volume":"75","author":"A Dray","year":"1995","unstructured":"Dray A (1995) Inflammatory mediators of pain. Br J Anaesth 75:125\u2013131","journal-title":"Br J Anaesth"},{"key":"6_CR29_6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1440-1681.1990.tb01367.x","volume":"17","author":"RG Evans","year":"1990","unstructured":"Evans RG, Ludbrook J, Michalicek J (1990) Characteristis of cardiovascular reflexes originating from 5-HT3 receptors in the heart and lungs of unanaethetized rabbits. Clin Exp Pharmacol Physiol 17:665\u2013679","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"6_CR30_6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4615-1833-4_8","volume":"366","author":"R Ferrari","year":"1994","unstructured":"Ferrari R (1994) Oxygen-free radicals at myocardial level: effects of ischaemia and reperfusion. Adv Exp Med Biol 366:99\u2013111","journal-title":"Adv Exp Med Biol"},{"key":"6_CR31_6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/newbio240200a0","volume":"240","author":"SH Ferreira","year":"1972","unstructured":"Ferreira SH (1972) Prostaglandins, aspirin-like drugs and analgesia. Nat New Biol 240:200\u2013203","journal-title":"Nat New Biol"},{"key":"6_CR32_6","doi-asserted-by":"crossref","first-page":"51B","DOI":"10.1016\/0002-9149(91)90384-W","volume":"68","author":"DJ Fitzgerald","year":"1991","unstructured":"Fitzgerald DJ (1991) Platelet activation in the pathogenesis of unstable angina: importance in determining the response to plasminogen activators. Am J Cardiol 68:51B\u201357B","journal-title":"Am J Cardiol"},{"key":"6_CR33_6","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1056\/NEJM198610163151602","volume":"315","author":"DJ Fitzgerald","year":"1986","unstructured":"Fitzgerald DJ, Roy L, Catella F, Fitzgerald GA (1986) Platelet activation in unstable coronary disease. N Engl J Med 315:983\u2013989","journal-title":"N Engl J Med"},{"key":"6_CR34_6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/cvr\/28.3.295","volume":"28","author":"NA Flores","year":"1994","unstructured":"Flores NA, Sheridan DJ (1994) The pathophysiological role of platelets during myocardial ischemia. Cardiovasc Res 28:295\u2013302","journal-title":"Cardiovasc Res"},{"key":"6_CR35_6","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1093\/cvr\/28.11.1662","volume":"28","author":"NA Flores","year":"1994","unstructured":"Flores NA, Goulielmos NV, Seghatchian MJ, Sheridan DJ (1994) Myocardial ischemia induces platelet activation with adverse electrophysiological and arrhythmogenic effects. Cardiovasc Res 28:1662\u20131671","journal-title":"Cardiovasc Res"},{"key":"6_CR36_6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.CIR.54.3.365","volume":"54","author":"JD Folts","year":"1994","unstructured":"Folts JD (1994) Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 54:365\u2013370","journal-title":"Circulation"},{"key":"6_CR37_6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.CIR.54.3.365","volume":"54","author":"JD Folts","year":"1976","unstructured":"Folts JD, Crowell EB Jr, Rowe GG (1976) Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 54:365\u2013370","journal-title":"Circulation"},{"key":"6_CR38_6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1161\/01.CIR.98.7.699","volume":"98","author":"N Frangogiannis","year":"1998","unstructured":"Frangogiannis N, ML Lindsey, LH Michael, KA Youker, RB Bressler, LH Mendoza, RN Spengler, CW Smith, ML Entman (1998) Resident cardiac mast cells degranulate and release preformed TNF-\u03b1, initiating the cytokine cascade in experimental canaine myocardial ischemia\/reperfusion. Circulation 98:699\u2013710","journal-title":"Circulation"},{"key":"6_CR39_6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1469-7793.1998.729bm.x","volume":"509","author":"L-W Fu","year":"1998","unstructured":"Fu L-W, Longhurst JC (1998) Role of 5-HT3 receptors in activation of abdominal sympathetic C-fibre afferents during ischemia in cats. J Physiol (Lond) 509:729\u2013740","journal-title":"J Physiol (Lond)"},{"key":"6_CR40_6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1113\/jphysiol.2002.023374","volume":"544","author":"L-W Fu","year":"2002","unstructured":"Fu L-W, Longhurst JC (2002a) Activated platelets contribute to stimulation of cardiac afferents during ischaemia in cats: role of 5-HT3 receptors. J Physiol (Lond) 544:897\u2013912","journal-title":"J Physiol (Lond)"},{"key":"6_CR41_6","first-page":"H100","volume":"282","author":"L-W Fu","year":"2002","unstructured":"Fu L-W, Longhurst JC (2002b) Role of activated platelets in excitation of cardiac afferents during myocardial ischemia in cats. Am J Physiol 282:H100\u2013H109","journal-title":"Am J Physiol"},{"key":"6_CR42_6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1113\/jphysiol.2005.084004","volume":"565","author":"L-W Fu","year":"2005","unstructured":"Fu L-W, Longhurst JC (2005) Interactions between histamine and bradykinin in stimulation of ischaemically sensitive cardiac afferents in felines. J Physiol (Lond) 565:1007\u20131017","journal-title":"J Physiol (Lond)"},{"key":"6_CR43_6","first-page":"1230.4","volume":"22","author":"L-W Fu","year":"2008","unstructured":"Fu L-W, Longhurst JC (2008) Reciprocal interactions between bradykinin and thromboxane A2 during stimulation of ischemically sensitive cardiac spinal afferents. FASEB J 22:1230.4","journal-title":"FASEB J"},{"key":"6_CR44_6","first-page":"H2726","volume":"273","author":"L-W Fu","year":"1997","unstructured":"Fu L-W, Pan H-L, Longhurst JC (1997) Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors. Am J Physiol 273:H2726\u2013H2737","journal-title":"Am J Physiol"},{"key":"6_CR46_6","first-page":"H2530","volume":"295","author":"L-W Fu","year":"2008a","unstructured":"Fu L-W, Phan A, Longhurst JC (2008a) Myocardial Ischemia-Mediated Excitatory Reflexes: A New Function for Thromboxane A2? Am J Physiol 295:H2530\u2013H2540","journal-title":"Am J Physiol"},{"key":"6_CR45_6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1152\/jn.00528.2004","volume":"93","author":"L-W Fu","year":"2005","unstructured":"Fu L-W, Schunack W, Longhurst JC (2005) Histamine contributes to ischemia-related activation of cardiac spinal afferents: role of H1 receptors and PKC. J Neurophysiol 93:713\u2013722","journal-title":"J Neurophysiol"},{"issue":"13","key":"6_CR198_6","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1113\/jphysiol.2007.148106","volume":"586","author":"LW Fu","year":"2008","unstructured":"Fu LW, Guo ZL, Longhurst JC (2008b) Undiscovered role of endogenous TxA2 in activation of cardiac sympathetic afferents during ischemia. J Physiol 586(13):3287\u20133300","journal-title":"J Physiol"},{"key":"6_CR47_6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0160-5402(82)90022-5","volume":"7","author":"T Fujimori","year":"1982","unstructured":"Fujimori T, Yamanishi Y, Yamatsu K, Tajima T (1982) High performance liquid chromatography (HPLC) determination of endogenous serotonin released from aggregating platelets. J Pharmacol Methods 7:105\u2013113","journal-title":"J Pharmacol Methods"},{"key":"6_CR48_6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3565(25)20303-2","volume":"258","author":"L Furci","year":"1991","unstructured":"Furci L, Fitzgerald DJ, Fitzgerald GA (1991) Heterogeneity of prostaglandin H2\/thromboxane A2 receptors: distinct subtypes mediate vascular smooth muscle contraction and platelet aggregation. J Pharmacol Exp Ther 258:74\u201381","journal-title":"J Pharmacol Exp Ther"},{"key":"6_CR49_6","doi-asserted-by":"crossref","first-page":"H734","DOI":"10.1152\/ajpcell.1997.273.2.C734","volume":"273","author":"H Gao","year":"1997","unstructured":"Gao H, Welch WJ, DiBona GF, Wilcox CS (1997) Sympathetic nervous system and hypertension during prolonged TxA2\/PGH2 receptor activation in rats. Am J Physiol 273:H734\u2013H739","journal-title":"Am J Physiol"},{"key":"6_CR50_6","doi-asserted-by":"crossref","first-page":"G834","DOI":"10.1152\/ajpgi.2000.278.6.G834","volume":"278","author":"GF Gebhart","year":"2000","unstructured":"Gebhart GF (2000) Pathobiology of visceral pain: molecular mechanisms and therapeutic implications IV. Visceral afferent contributions to the pathobiology of visceral pain. Am J Physiol Gastrointest Liver Physiol 278:G834\u2013G838","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"6_CR51_6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0002-8703(81)90030-2","volume":"102","author":"R Ginsburg","year":"1981","unstructured":"Ginsburg R, Bristow M, Kantrowitz N, Baim D, Harrison D (1981) Histamine provocation of clinical coronary artery spasm: Implications concerning pathogenesis of variant angina pectoris. Am Heart J 102:819\u2013822","journal-title":"Am Heart J"},{"key":"6_CR52_6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0165-1838(94)00169-K","volume":"53","author":"T Gnecchi-Ruscone","year":"1995","unstructured":"Gnecchi-Ruscone T, Montano N, Contini M, Guazzi M, Lombardi F, Malliani A (1995) Adenosine activates cardiac sympathetic afferent fibers and potentiates the excitation induced by coronary occlusion. J Auton Nerv Syst 53:175\u2013184","journal-title":"J Auton Nerv Syst"},{"key":"6_CR53_6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJM199402243300802","volume":"330","author":"P Golino","year":"1994","unstructured":"Golino P, Piscione F, Benedict C, Anderson H, Cappelli-Bigazzi M, Indolfi C, Condorelli M, Chiariello M, Willerson J (1994) Local effect of serotonin released during coronary angioplasty. N Engl J Med 330:523\u2013528","journal-title":"N Engl J Med"},{"issue":"suppl I","key":"6_CR54_6","first-page":"I16","volume":"81","author":"P Grande","year":"1990","unstructured":"Grande P, Grauholt A-M, Madsen JK (1990) Unstable angina pectoris: platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. Circulation 81(suppl I):I16\u2013I19","journal-title":"Circulation"},{"key":"6_CR55_6","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/0735-1097(92)90457-X","volume":"20","author":"HP Grill","year":"1992","unstructured":"Grill HP, Zweier P, Kuppusamy ML, Weisfeldt ML, Flaherty JT (1992) Direct measurement of myocardial free radical generation in an in vivo model: effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase. J Am Coll Cardiol 20:1604\u20131611","journal-title":"J Am Coll Cardiol"},{"key":"6_CR56_6","doi-asserted-by":"crossref","first-page":"6S","DOI":"10.1007\/BF01538126","volume":"33","author":"MB Grisham","year":"1988","unstructured":"Grisham MB, Granger DN (1988) Neutrophil-mediated mucosal injury: role of reactive oxygen metabolites. Dig Dis Sci 33:6S\u201315S","journal-title":"Dig Dis Sci"},{"issue":"suppl","key":"6_CR57_6","doi-asserted-by":"crossref","first-page":"44S","DOI":"10.1007\/BF02300369","volume":"30","author":"D Grundy","year":"1994","unstructured":"Grundy D, Blackshae LA, Hillsley K (1994) Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity. Dig Dis Sci 30(suppl):44S\u201347S","journal-title":"Dig Dis Sci"},{"key":"6_CR58_6","first-page":"H843","volume":"278","author":"Z-L Guo","year":"2000","unstructured":"Guo Z-L, Longhurst J (2000) Role of cAMP in activation of ischemically sensitive abdominal visceral afferents. Am J Physiol 278:H843\u2013H852","journal-title":"Am J Physiol"},{"key":"6_CR59_6","first-page":"H1024","volume":"275","author":"Z-L Guo","year":"1998","unstructured":"Guo Z-L, Fu L-W, Symons J, Longhurst J (1998) Signal transduction in activation of ischemically sensitive abdominal visceral afferents: role of PKC. Am J Physiol 275:H1024\u2013H1031","journal-title":"Am J Physiol"},{"key":"6_CR60_6","first-page":"H1884","volume":"276","author":"Z-L Guo","year":"1999","unstructured":"Guo Z-L, JD Symons, JC Longhurst (1999) Activation of visceral afferents by bradykinin and ischemia: independent roles of PKC and prostaglandins. Am J Physiol 276:H1884\u2013H1891","journal-title":"Am J Physiol"},{"key":"6_CR61_6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0891-5849(89)90145-7","volume":"7","author":"B Halliwell","year":"1989","unstructured":"Halliwell B (1989) Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action? Free Radic Biol Med 7:645\u2013651","journal-title":"Free Radic Biol Med"},{"key":"6_CR62_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0076-6879(90)86093-B","volume":"186","author":"B Halliwell","year":"1990","unstructured":"Halliwell B, Gutteridge JMC (1990) Role of free radicals and catalytic metal ions in human disease. An overview. Meth Enzymol 186:1\u201385","journal-title":"An overview. Meth Enzymol"},{"key":"6_CR63_6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1536\/ihj.18.679","volume":"5","author":"K Hashimoto","year":"1977","unstructured":"Hashimoto K, Hirose M, Furukawa S, Hayakawa H, Kimura E (1977) Changes in hemodynamics and bradykinin concentration in coronary sinus blood in experimental coronary artery occlusion. Jpn Heart J 5:679\u2013689","journal-title":"Jpn Heart J"},{"key":"6_CR64_6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1006886601825","volume":"166","author":"SC Hendrickson","year":"1997","unstructured":"Hendrickson SC, St Louis JD, Lowe JE, bdel-Aleem S (1997) Free fatty acid metabolism during myocardial ischemia and reperfusion. Mol Cell Biochem 166:85\u201394","journal-title":"Mol Cell Biochem"},{"key":"6_CR65_6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3940(01)01817-1","volume":"305","author":"MK Herbert","year":"2001","unstructured":"Herbert MK, Just H, Schmidt RF (2001) Histamine excites groups III and IV afferents from the cat knee joint depending on their resting activity. Neurosci Lett 305:95\u201398","journal-title":"Neurosci Lett"},{"key":"6_CR66_6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6997(24)01328-0","volume":"49","author":"SJ Hill","year":"1997","unstructured":"Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol Rev 49:253\u2013278","journal-title":"Pharmacol Rev"},{"key":"6_CR67_6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0022-5223(97)70414-8","volume":"113","author":"Y Hiramatsu","year":"1997","unstructured":"Hiramatsu Y, Gikakis N, Anderson III HL, Gorman III JH, Marcinkiewicz C, Gould RJ, Niewiarowski S, Edmunds LH Jr (1997) Tirofiban provides \u201cplatelet anesthesia\u201d during cardiopulmonary bypass in baboons. J Thorac Cardiovasc Surg 113:193","journal-title":"J Thorac Cardiovasc Surg"},{"key":"6_CR68_6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM198103193041201","volume":"304","author":"P Hirsh","year":"1981","unstructured":"Hirsh P, Hillis L, Campbell W, Firth B, Willerson J (1981) Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. N Engl J Med 304:685\u2013691","journal-title":"N Engl J Med"},{"key":"6_CR69_6","first-page":"219","volume":"22","author":"H Holmsen","year":"1985","unstructured":"Holmsen H (1985) Platelet metabolism and activation. Sem Hematol 22:219\u2013240","journal-title":"Sem Hematol"},{"key":"6_CR70_6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00001574-200111000-00003","volume":"17","author":"P Holzer","year":"2001","unstructured":"Holzer P (2001) Gastroduodenal mucosal defense: coordination by a network of messengers and mediators. Curr Opin Gastroenterol 17:489\u2013496","journal-title":"Curr Opin Gastroenterol"},{"key":"6_CR71_6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1113\/jphysiol.1997.sp022023","volume":"500","author":"JL Hong","year":"1997","unstructured":"Hong JL, Kwong K, Lee LY (1997) Stimulation of pulmonary C fibers by lactic acid in rats: concentrations of H+ and lactate ions. J Physiol 500:319\u2013329","journal-title":"J Physiol"},{"key":"6_CR72_6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0031-6997(25)06783-3","volume":"46","author":"D Hoyer","year":"1994","unstructured":"Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ (1994) International union of parmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46:157\u2013203","journal-title":"Pharmacol Rev"},{"key":"6_CR73_6","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1111\/j.1476-5381.1996.tb15666.x","volume":"118","author":"KS Hsu","year":"1996","unstructured":"Hsu KS, Han WM (1996) Thromboxane A2 agonist modulation of excitatory synaptic transmission in hte rat hippocampal slice. Br J Pharmacol 118:2220\u20132227","journal-title":"Br J Pharmacol"},{"key":"6_CR74_6","first-page":"H888","volume":"269","author":"H-S Huang","year":"1995","unstructured":"Huang H-S, Pan H-L, Stahl G, Longhurst J (1995a) Ischemia- and reperfusion-sensitive cardiac sympathetic afferents: influence of H2O2 and hydroxyl radicals. Am J Physiol 269:H888\u2013H901","journal-title":"Am J Physiol"},{"key":"6_CR75_6","first-page":"H2114","volume":"268","author":"H-S Huang","year":"1995","unstructured":"Huang H-S, Stahl G, Longhurst J (1995b) Cardiac-cardiovascular reflexes induced by hydrogen peroxide in cats. Am J Physiol 268:H2114\u2013H2124","journal-title":"Am J Physiol"},{"key":"6_CR76_6","doi-asserted-by":"crossref","first-page":"R318","DOI":"10.1152\/ajpcell.1995.269.2.C318","volume":"269","author":"MH Huang","year":"1995","unstructured":"Huang MH, Sylven C, Horackova M, Armour JA (1995c) Ventricular sensory neurons in canine dorsal root ganglia: effects of adenosine and substance P. Am J Physiol 269:R318\u2013R324","journal-title":"Am J Physiol"},{"key":"6_CR77_6","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0091-6749(05)80204-0","volume":"86","author":"M Ichinose","year":"1990","unstructured":"Ichinose M, Barnes PJ (1990) Histamine H3 receptors modulate antigen-induced bronchoconstriction in guinea pigs. J Allergy Clin Immunol 86:491\u2013495","journal-title":"J Allergy Clin Immunol"},{"key":"6_CR78_6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/01.RES.77.1.206","volume":"77","author":"M Imamura","year":"1995","unstructured":"Imamura M, Seyedi N, Lander HM, Levi R (1995) Functional idendification of histamine H3-receptors in the human heart. Circ Res 77:206\u2013210","journal-title":"Circ Res"},{"key":"6_CR79_6","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/01.RES.78.5.863","volume":"78","author":"M Imamura","year":"1996","unstructured":"Imamura M, Smith NC, Garbarg M, Levi R (1996) Histamine H3-receptor-mediated inhibition of calcitonin gene-related peptide release from cardiac C fibers. A regulatory negative-feedback loop. Circ Res 78:863\u2013869","journal-title":"Circ Res"},{"key":"6_CR80_6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0896-6273(02)01130-3","volume":"37","author":"DC Immke","year":"2003","unstructured":"Immke DC, McCleskey EW (2003) Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade. Neuron 37:75\u201384","journal-title":"Neuron"},{"key":"6_CR81_6","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1152\/jappl.1985.59.6.1995","volume":"59","author":"JH Jackson","year":"1985","unstructured":"Jackson JH, White CW, Parker NB, Ryan JW, Repine JE (1985) Dimethylthiourea consumption reflects H2O2 concentrations and severity of acute lung injury. J Appl Physiol 59:1995\u20131998","journal-title":"J Appl Physiol"},{"key":"6_CR82_6","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/01.RES.49.4.892","volume":"49","author":"RB Jennings","year":"1981","unstructured":"Jennings RB, Reimer KA, Hill ML, Mayer SE (1981) Total ischemia in dog heart in vitro. 1. Comparison of high energy phosphate production, utilization, an depletion, and of adenine nucleotide catabolism in total ischemia in vitro vs. severe ischemia in vivo. Circulation 49:892\u2013900","journal-title":"Circulation"},{"key":"6_CR83_6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/expphysiol.2004.029058","volume":"90","author":"D Jordan","year":"2005","unstructured":"Jordan D (2005) Vagal control of the heart: central serotonergic (5-HT) mechanisms. Exp Physiol 90:175\u2013181","journal-title":"Exp Physiol"},{"key":"6_CR84_6","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1073\/pnas.100129497","volume":"97","author":"SE Jordt","year":"2000","unstructured":"Jordt SE, Tominaga M, Julius D (2000) Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci USA 97:8134\u20138139","journal-title":"Proc Natl Acad Sci USA"},{"key":"6_CR85_6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1113\/jphysiol.1977.sp012074","volume":"272","author":"CT Kappagoda","year":"1977","unstructured":"Kappagoda CT, Linden RJ, Mary DASG (1977) Atrial receptors in the dog and rabbit. J Physiol 272:799\u2013815","journal-title":"J Physiol"},{"key":"6_CR86_6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1113\/jphysiol.1979.sp012821","volume":"291","author":"CT Kappagoda","year":"1979","unstructured":"Kappagoda CT, Linden RJ, Sivananthan N (1979) The nature of the atrial receptors responsible for a reflex increase in heart rate in the dog. J Physiol 291:393\u2013412","journal-title":"J Physiol"},{"key":"6_CR87_6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0034-5687(92)90019-S","volume":"87","author":"W Karla","year":"1992","unstructured":"Karla W, Shams H, Orr JA, Scheid P (1992) Effects of the thromboxane A2 mimetic, U46,619, on pulmonary vagal afferents in the cat. Respir Physiol 87:383\u2013396","journal-title":"Respir Physiol"},{"key":"6_CR88_6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0169-328X(98)00346-5","volume":"66","author":"H Kashiba","year":"1999","unstructured":"Kashiba H, Fukui H, Morikawa Y, Senba E (1999) Gene expression of histamine H1 receptor in guinea pig primary sensory neurons: a relationship between H1 receptor mRNA-expressing neurons and peptidergic neurons. Brain Res Mol Brain Res 66:24\u201334","journal-title":"Brain Res Mol Brain Res"},{"key":"6_CR89_6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/01.RES.46.4.476","volume":"46","author":"MP Kaufman","year":"1980","unstructured":"Kaufman MP, Baker DG, Coleridge HM, Coleridge JCG (1980) Stimulation by bradykinin of afferent vagal C-fibers with chemosensitive endings in the heart and aorta of the dog. Circ Res 46:476\u2013484","journal-title":"Circ Res"},{"key":"6_CR90_6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.RES.50.1.133","volume":"50","author":"MP Kaufman","year":"1982","unstructured":"Kaufman MP, Iwamoto GA, Longhurst JC, Mitchell JH (1982) Effects of capsaicin and bradykinin on afferent fibers with endings in skeletal muscle. Circ Res 50:133\u2013139","journal-title":"Circ Res"},{"key":"6_CR91_6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0006-8993(96)01211-5","volume":"744","author":"J Kenagy","year":"1997","unstructured":"Kenagy J, VanCleave J, Pazdernik L, Orr JA (1997) Stimulation of group III and IV afferent nerves from the hindlimb by thromboxane A2. Brain Res 744:175\u2013178","journal-title":"Brain Res"},{"key":"6_CR92_6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0002-8703(73)90169-5","volume":"85","author":"E Kimura","year":"1973","unstructured":"Kimura E, Hashimoto K, Furukawa S, Hayakawa H (1973) Changes in bradykinin level in coronary sinus blood after the experimental occulsion of a coronary artery. Am Heart J 85:635\u2013647","journal-title":"Am Heart J"},{"key":"6_CR93_6","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1152\/jn.00593.2001","volume":"87","author":"H Koda","year":"2002","unstructured":"Koda H, Mizumura K (2002) Sensitization to mechanical stimulation by inflammatory mediators and by mild burn in canine visceral nociceptors in vitro. J Neurophysiol 87:2043\u20132051","journal-title":"J Neurophysiol"},{"key":"6_CR94_6","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1152\/jn.1996.76.3.1396","volume":"76","author":"H Koda","year":"1996","unstructured":"Koda H, Minagawa M, Si-Hong L, Mizumura K, Kumazawa T (1996) H1-receptor-mediated excitation and facilitation of the heat response by histamine in canine visceral polymodal receptors studied in vitro. J Neurophysiol 76:1396\u20131404","journal-title":"J Neurophysiol"},{"key":"6_CR95_6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/eujp.2001.0226","volume":"5","author":"W Koppert","year":"2001","unstructured":"Koppert W, Martus P, Reeh PW (2001) Interactions of histamine and bradykinin on polymodal C-fibres in isolated rat skin. Eur J Pain 5:97\u2013106","journal-title":"Eur J Pain"},{"key":"6_CR96_6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1742-1241.1991.tb10251.x","volume":"45","author":"NG Kounis","year":"1991","unstructured":"Kounis NG, Zavras GM (1991) Histamine-induced coronary artery spasm: the concept of allergic angina. Br J Clin Pract 45:121\u2013127","journal-title":"Br J Clin Pract"},{"key":"6_CR97_6","doi-asserted-by":"crossref","first-page":"9880","DOI":"10.1016\/S0021-9258(18)81740-9","volume":"264","author":"P Kuppusamy","year":"1989","unstructured":"Kuppusamy P, Zweier JL (1989) Characterization of free radical generation by xanthine oxidase. Evidence for hydroxyl radical generation. J Biol Chem 264:9880\u20139884","journal-title":"J Biol Chem"},{"key":"6_CR98_6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/01.CIR.99.3.361","volume":"99","author":"P Laine","year":"1999","unstructured":"Laine P, Kaartinen M, Penttila A, Panula P, Paavonen T, Kovanen PT (1999) Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery. Circulation 99:361\u2013369","journal-title":"Circulation"},{"key":"6_CR99_6","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1161\/01.CIR.101.14.1665","volume":"101","author":"P Laine","year":"2000","unstructured":"Laine P, Naukkarinen A, Heikkila L, Penttila A, Kovanen PT (2000) Adventitial mast cells connect with sensory nerve fibers in atherosclerotic coronary arteries. Circulation 101:1665\u20131669","journal-title":"Circulation"},{"key":"6_CR100_6","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1111\/j.1476-5381.1995.tb16410.x","volume":"116","author":"OL Leanos","year":"1995","unstructured":"Leanos OL, Hong E, Amezcua JL (1995) Reflex circulatory collapse following intrapulmonary entrapment of activated platelets: mediation via 5-HT3 receptor stimulation. Br J Pharmacol 116:2048\u20132052","journal-title":"Br J Pharmacol"},{"key":"6_CR101_6","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1056\/NEJM199506083322306","volume":"332","author":"J Lefkovits","year":"1995","unstructured":"Lefkovits J, Plow EF, Topol EJ (1995) Platelet glycoprotein IIb\/IIIa receptors in cardiovascular medicine. N Engl J Med 332:1553\u20131559","journal-title":"N Engl J Med"},{"key":"6_CR102_6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00495769","volume":"80","author":"JI Lehtosalo","year":"1984","unstructured":"Lehtosalo JI, Uusitalo H, Laakso J, Palkama A, Harkonen M (1984) Biochemical and immunohistochemical determination of 5-hydroxytryptamine located in mast cells in the trigeminal ganglion of the rat and guinea pig. Histochemistry 80:219\u2013223","journal-title":"Histochemistry"},{"key":"6_CR103_6","first-page":"R465","volume":"250","author":"WYW Lew","year":"1986","unstructured":"Lew WYW, Longhurst JC (1986) Substance P, 5-hydroxytryptamine, and bradykinin stimulate abdominal visceral afferents. Am J Physiol 250:R465\u2013R473","journal-title":"Am J Physiol"},{"key":"6_CR104_6","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/01.CIR.61.6.1165","volume":"61","author":"RI Lewy","year":"1980","unstructured":"Lewy RI, Wiener L, Walinsky P, Lefer AM, Silver MJ, Smith JB (1980) Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature. Circulation 61:1165\u20131171","journal-title":"Circulation"},{"key":"6_CR105_6","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0735-1097(00)00554-4","volume":"35","author":"MA Lincoff","year":"2000","unstructured":"Lincoff MA, Califf RM, Topol EJ (2000) Platelet glycoprotein IIb\/IIia receptor blockade in coronary artery disease. J A Coll Cardiol 35:1103\u20131115","journal-title":"J A Coll Cardiol"},{"key":"6_CR106_6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0033-0620(84)90005-7","volume":"XXVII","author":"JC Longhurst","year":"1984","unstructured":"Longhurst JC (1984) Cardiac receptors: Their function in health and disease. Prog Cardiovasc Dis XXVII:201\u2013222","journal-title":"Prog Cardiovasc Dis"},{"key":"6_CR107_6","first-page":"H556","volume":"253","author":"J Longhurst","year":"1987","unstructured":"Longhurst J, Dittman L (1987) Hypoxia, bradykinin, and prostaglandins stimulate ischemically sensitive visceral afferents. Am J Physiol 253:H556\u2013H567","journal-title":"Am J Physiol"},{"key":"6_CR108_6","first-page":"H2075","volume":"261","author":"J Longhurst","year":"1991","unstructured":"Longhurst J, Rotto D, Kaufman M, Stahl G (1991) Ischemically sensitive abdominal visceral afferents: response to cyclooxygenase blockade. Am J Physiol 261:H2075\u2013H2081","journal-title":"Am J Physiol"},{"key":"6_CR109_6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1749-6632.2001.tb03668.x","volume":"940","author":"J Longhurst","year":"2001","unstructured":"Longhurst J, Tjen-A-Looi S, Fu L-W (2001) Cardiac sympathetic afferent activation provoked by myocardial ischemia and reperfusion: mechanisms and reflexes. Ann N Y Acad Sci 940:74\u201395","journal-title":"Ann N Y Acad Sci"},{"key":"6_CR110_6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0165-1838(81)90065-5","volume":"3","author":"A Malliani","year":"1981","unstructured":"Malliani A, Lombardi F, Pagani M (1981) Functions of afferents in cardiovascular sympathetic nerves. J Auton Nerv Syst 3:231\u2013236","journal-title":"J Auton Nerv Syst"},{"key":"6_CR111_6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1152\/ajplegacy.1974.227.2.273","volume":"227","author":"AL Mark","year":"1974","unstructured":"Mark AL, Abboud FM, Heistad DD, Schmid PG, Johannsen UJ (1974) Evidence against the presence of ventricular chemoreceptors activated by hypoxia and hypercapnia. Am J Physiol 227:273\u2013279","journal-title":"Am J Physiol"},{"key":"6_CR112_6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF02074691","volume":"20","author":"E Masini","year":"1987","unstructured":"Masini E, Giannella E, Bianchi S, Mannaioni PF (1987) Histamine and lactate dehydrogenase (LDH) release in ischemic myocardium of the guinea-pig. Agents Actions 20:281\u2013283","journal-title":"Agents Actions"},{"key":"6_CR113_6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s000110050319","volume":"47","author":"E Masini","year":"1998","unstructured":"Masini E, Di Bello MG, Raspanti S, Fomusi Ndisang J, Baronti R, Cappugi P, Mannaioni PF (1998) The role of histamine in platelet aggregation by physiological and immunological stimuli. Inflamm Res 47:211\u2013220","journal-title":"Inflamm Res"},{"key":"6_CR114_6","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1152\/ajpregu.00007.2002","volume":"283","author":"SB Mazzone","year":"2002","unstructured":"Mazzone SB, Canning BJ (2002) Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs. Am J Physiol Regul Integr Comp Physiol 283:R86\u2013R98","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"6_CR115_6","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0002-8703(84)90376-4","volume":"107","author":"J Mehta","year":"1984","unstructured":"Mehta J, Mehta P, Feldman R, Horalek C (1984) Thromboxane release in coronary artery disease: spontaneous versus pacing-induced angina. Am Heart J 107:286\u2013292","journal-title":"Am Heart J"},{"key":"6_CR116_6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0306-4522(92)90398-L","volume":"48","author":"ST Meller","year":"1992","unstructured":"Meller ST, Gebhart GF (1992) A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain. Neuroscience 48:501\u2013524","journal-title":"Neuroscience"},{"key":"6_CR117_6","first-page":"R454","volume":"243","author":"KM Meyers","year":"1982","unstructured":"Meyers KM, Holsmen H, Seachord CL (1982) Comparative study of platelet dense granule constituents. Am J Physiol 243:R454\u2013R461","journal-title":"Am J Physiol"},{"key":"6_CR118_6","doi-asserted-by":"crossref","first-page":"H1944","DOI":"10.1152\/ajpheart.00329.2004","volume":"5","author":"HR Middlekauff","year":"2004","unstructured":"Middlekauff HR, Chiu J (2004) Cyclooxygenase products sensitize muscle mechanoreceptors in healthy humans. Am J Physiol Heart Circ Physiol 5:H1944\u2013H1949","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"6_CR119_6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/BF01797864","volume":"44","author":"K Mizumura","year":"1995","unstructured":"Mizumura K, Minagawa M, Koda H, Kumazawa T (1995) Influence of histamine on the bradykinin response of canine testicular polymodal receptors in vitro. Inflamm Res 44:376\u2013378","journal-title":"Inflamm Res"},{"key":"6_CR120_6","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1046\/j.1471-4159.2001.00378.x","volume":"78","author":"N Muja","year":"2001","unstructured":"Muja N, Blackman SC, Le Breton GC, DeVries GH (2001) Identification and functional characterization of thromboxane A2 receptors in Schwann cells. J Neurochem 78:446\u2013456","journal-title":"J Neurochem"},{"key":"6_CR121_6","first-page":"501","volume":"43","author":"K Nakahodo","year":"1994","unstructured":"Nakahodo K, Saitoh S, Nakamura M, Kosugi T (1994) Histamine release from rabbit platelets by platelet-activating factor (PAF). Arerugi 43:501\u2013510","journal-title":"Arerugi"},{"key":"6_CR122_6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1440-1681.2007.04608.x","volume":"34","author":"LS Nandam","year":"2007","unstructured":"Nandam LS, Jhaveri D, Bartlett P (2007) 5-HT7, neurogenesis and antidepressants: a promising therapeutic axis for treating depression. Clin Exp Pharmacol Physiol 34:546\u2013551","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"6_CR123_6","first-page":"R815","volume":"250","author":"T Nerdrum","year":"1986","unstructured":"Nerdrum T, Baker D, Coleridge H, Coleridge J (1986) Interaction of bradykinin and prostaglandin E1 on cardiac pressor reflex and sympathetic afferents. Am J Physiol 250:R815\u2013R822","journal-title":"Am J Physiol"},{"key":"6_CR124_6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0306-4522(01)00561-9","volume":"110","author":"TA Nicolson","year":"2002","unstructured":"Nicolson TA, Bevan S, Richards CD (2002) Characterisation of the calcium responses to histamine in capsaicin-sensitive and capsaicin-insensitive sensory neurones. Neuroscience 110:329\u2013338","journal-title":"Neuroscience"},{"key":"6_CR125_6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0304-3940(85)90109-0","volume":"53","author":"M Ninkovic","year":"1985","unstructured":"Ninkovic M, Hunt SP (1985) Opiate and histamine H1 receptors are present on some substance P-containing dorsal root ganglion cells. Neurosci Lett 53:133\u2013137","journal-title":"Neurosci Lett"},{"key":"6_CR126_6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00582206","volume":"372","author":"K Nishi","year":"1977","unstructured":"Nishi K, Sakanashi M, Takenaka F (1977) Activation of afferent cardiac sympathetic nerve fibers of the cat by pain producing substances and by noxious heat. Pflugers Arch 372:53\u201361","journal-title":"Pflugers Arch"},{"key":"6_CR127_6","first-page":"H660","volume":"271","author":"CA O'Neill","year":"1996","unstructured":"O'Neill CA, Fu L-W, Halliwell B, Longhurst JC (1996) Hydroxyl radical production during myocardial ischemia and reperfusion in cats. Am J Physiol 271:H660\u2013H667","journal-title":"Am J Physiol"},{"key":"6_CR128_6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1748-1716.1973.tb05373.x","volume":"87","author":"B Oberg","year":"1973","unstructured":"Oberg B, Thoren PN (1973) Circulatory responses to stimulation of medullated and non-medullated afferents in the cardiac nerve in the cat. Acta Physiol Scand 87:121\u2013132","journal-title":"Acta Physiol Scand"},{"key":"6_CR129_6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0002-9149(73)80137-7","volume":"32","author":"LH Opie","year":"1973","unstructured":"Opie LH, Owen P, Thomas M, Samson R (1973) Coronary sinus lactic measurements in assessment of myocardial ischemia. Am J Cardiol 32:295\u2013305","journal-title":"Am J Cardiol"},{"key":"6_CR130_6","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1055\/s-0038-1649678","volume":"70","author":"MG oude Egbrink","year":"1993","unstructured":"oude Egbrink MG, Tangelder GJ, Slaaf DW, Reneman RS (1993) Different roles of prostaglandins in thromboembolic processes in arterioles and venules in vivo. Thromb Haemost 70:826\u2013833","journal-title":"Thromb Haemost"},{"key":"6_CR131_6","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1182\/blood.V50.5.915.915","volume":"50","author":"MA Packham","year":"1977","unstructured":"Packham MA, Guccione MA, Greenberg JP, Kinlough-Rathbone RL, Mustard JF (1977) Release of 14C-serotonin during initial platelet changes induced by thrombin, collagen, or A23187. Blood 50:915\u2013926","journal-title":"Blood"},{"key":"6_CR132_6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0300-9629(91)90130-5","volume":"99","author":"MA Packham","year":"1991","unstructured":"Packham MA, Rand ML, Ruben DH, Kinlough-Rathbone RL (1991) Effect of calcium concentration and inhibitors on the responses of platelets stimulated with collagen: contrast between human and rabbit platelets. Comp Biochem Physiol A 99:551\u2013557","journal-title":"Comp Biochem Physiol A"},{"key":"6_CR133_6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/01.RES.56.2.175","volume":"56","author":"M Pagani","year":"1985","unstructured":"Pagani M, Pizzinelli R, furlan R, Guzzetti S, Rimoldi O, Sandrone G, Malliani A (1985) Analysis of the pressor sympathetic reflex produced by intracoronary injections of bradykinin in conscious dogs. Circ Res 56:175\u2013183","journal-title":"Circ Res"},{"key":"6_CR134_6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/physrev.1973.53.1.159","volume":"53","author":"AS Paintal","year":"1973","unstructured":"Paintal AS (1973) Vagal sensory receptors and their reflex effects. Physiol Rev 53:159\u2013227","journal-title":"Physiol Rev"},{"key":"6_CR135_6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2170\/jjphysiol.39.131","volume":"39","author":"P Pal","year":"1989","unstructured":"Pal P, Koley J, Bhattacharyya S, Gupta JS, Koley B (1989) Cardiac nociceptors and ischemia: role of sympathetic afferents in cat. Jpn J Physiol 39:131\u2013144","journal-title":"Jpn J Physiol"},{"key":"6_CR136_6","first-page":"H106","volume":"269","author":"H-L Pan","year":"1995","unstructured":"Pan H-L, Longhurst J (1995) Lack of a role of adenosine in activation of ischemically sensitive cardiac sympathetic afferents in cats. Am J Physiol 269:H106\u2013H113","journal-title":"Am J Physiol"},{"key":"6_CR137_6","first-page":"H2398","volume":"267","author":"H-L Pan","year":"1994","unstructured":"Pan H-L, Stahl GL, Rendig SV, Carretero OA, Longhurst JC (1994) Endogenous BK stimulates ischemically sensitive abdominal visceral C fiber afferents through kinin B2 receptors. Am J Physiol 267:H2398\u2013H2406","journal-title":"Am J Physiol"},{"key":"6_CR138_6","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1469-7793.1999.0857p.x","volume":"518.3","author":"H-L Pan","year":"1999","unstructured":"Pan H-L, Longhurst JC, Eisenach JC, Chen S-R (1999) Role of protons in activation of cardiac sympathetic C-fiber afferents during ischemia. J Physiol 518.3:857\u2013866","journal-title":"J Physiol"},{"key":"6_CR139_6","first-page":"21","volume-title":"Rostaglandins and Thromboxanes: Proceedings of the Third International Symposium on Prostaglandins and Thromboxanes in the Cardiovascular System","author":"JR Parratt","year":"1981","unstructured":"Parratt JR, Cokerm S (1981) The significance of prostaglandin and thromboxane release in acute myocardial ischemia. In: Forster W (ed) Rostaglandins and Thromboxanes: Proceedings of the Third International Symposium on Prostaglandins and Thromboxanes in the Cardiovascular System. Pergamon, New York, pp 21\u201325"},{"key":"6_CR140_6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00441-002-0682-0","volume":"311","author":"L Patterson","year":"2003","unstructured":"Patterson L, Patterson L, Patterso, Patterson LM, Zheng H, Ward SM, Berhoud H-R (2003) Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract. Cell Tissue Res 311:277\u2013287","journal-title":"Cell Tissue Res"},{"key":"6_CR141_6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1471-4159.1993.tb03166.x","volume":"60","author":"SJ Peroutka","year":"1994","unstructured":"Peroutka SJ (1994) 5-Hydroxytryptamine receptors. J Neurochem 60:408\u2013416","journal-title":"J Neurochem"},{"key":"6_CR142_6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1046\/j.0953-816x.2001.01651.x","volume":"14","author":"G Petho","year":"2001","unstructured":"Petho G, Derow A, Reeh PW (2001) Bradykinin-induced nociceptor sensitization to heat is mediated by cyclooxygenase products in isolated rat skin. Eur J Neurosci 14:210\u2013218","journal-title":"Eur J Neurosci"},{"key":"6_CR144_6","doi-asserted-by":"crossref","first-page":"11B","DOI":"10.1016\/S0002-9149(97)00572-9","volume":"80","author":"DR Phillips","year":"1997","unstructured":"Phillips DR, Scarborough RM (1997) Clinical pharmacology of eptifibatide. Am J Cardiol 80:11B\u201320B","journal-title":"Am J Cardiol"},{"key":"6_CR145_6","first-page":"R706","volume":"275","author":"JG Pickar","year":"1998","unstructured":"Pickar JG (1998) The thromboxane A2 mimetic U-46619 inhibits somatomotor activity via a vagal reflex from the lung. Am J Physiol 275:R706\u2013R712","journal-title":"Am J Physiol"},{"key":"6_CR146_6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0022-2828(78)90010-X","volume":"10","author":"PA Poole-Wilson","year":"1978","unstructured":"Poole-Wilson PA (1978) Measurement of myocardial intracellular pH in pathological states. J Mol Cell Cardiol 10:511\u2013526","journal-title":"J Mol Cell Cardiol"},{"key":"6_CR147_6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/oxfordjournals.bmb.a072491","volume":"47","author":"HP Rang","year":"1991","unstructured":"Rang HP, Bevan SJ, Dray A (1991) Chemical activation of nociceptive peripheral neurons. Br Med Bull 47:534\u2013548","journal-title":"Br Med Bull"},{"key":"6_CR148_6","first-page":"263","volume":"37","author":"GHR Rao","year":"1993","unstructured":"Rao GHR (1993) Physiology of blood platelet activation. Indian J Physiol Pharmacol 37:263\u2013275","journal-title":"Indian J Physiol Pharmacol"},{"key":"6_CR149_6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11882-003-0044-3","volume":"3","author":"MS Repka-Ramirez","year":"2003","unstructured":"Repka-Ramirez MS (2003) New concepts of histamine receptors and actions. Curr Allergy Asthma Rep 3:227\u2013231","journal-title":"Curr Allergy Asthma Rep"},{"key":"6_CR150_6","first-page":"496","volume":"346","author":"KF Rhodes","year":"1992","unstructured":"Rhodes KF, Coleman J, Lattimer N (1992) A component of 5-HT-evoked depolarization of the rat isolated vagus nerve is mediated by a putative 5-HT4 receptor. Naunyn Schemiedebergs Arch Pharmacol 346:496\u2013503","journal-title":"Naunyn Schemiedebergs Arch Pharmacol"},{"key":"6_CR151_6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1749-6632.1990.tb16906.x","volume":"600","author":"BP Richardson","year":"1990","unstructured":"Richardson BP (1990) Serotonin and nociception. Ann N Y Acad Sci 600:511\u2013519","journal-title":"Ann N Y Acad Sci"},{"key":"6_CR152_6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3940(94)90249-6","volume":"170","author":"M Ringkamp","year":"1994","unstructured":"Ringkamp M, Schmelz M, Kress M, Allwang M, Ogilvie A, Reeh PW (1994) Activated human platelets in plasma excite nociceptors in rat skin, in vitro. Neurosci Lett 170:103\u2013106","journal-title":"Neurosci Lett"},{"key":"6_CR153_6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/jappl.1989.67.1.256","volume":"67","author":"DM Rotto","year":"1989","unstructured":"Rotto DM, Stebbins CL, Kaufman MP (1989) Reflex cardiovascular and ventilatory responses to increasing H+ activity in cat hindlimb muscle. J Appl Physiol 67:256\u2013263","journal-title":"J Appl Physiol"},{"key":"6_CR154_6","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1152\/jappl.1990.68.3.861","volume":"68","author":"D Rotto","year":"1990","unstructured":"Rotto D, Schultz H, Longhurst J, Kaufman M (1990) Sensitization of group III muscle afferents to static contraction by arachidonic acid metabolism. J Appl Physiol 68:861\u2013867","journal-title":"J Appl Physiol"},{"key":"6_CR155_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF03033792","volume":"2","author":"HT Rupniak","year":"2000","unstructured":"Rupniak HT, Joy KA, Atkin C (2000) Oxidative neuropathology and putative chemical entities for Alzheimer's disease: neuroprotective effects of salen-manganese catalytic anti-oxidants. Neurotox Res 2:167\u2013178","journal-title":"Neurotox Res"},{"key":"6_CR156_6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0735-1097(96)00158-1","volume":"28","author":"K Sakata","year":"1996","unstructured":"Sakata K, Yoshida H, Hoshino T, Kurata C (1996) Sympathetic nerve activity in the spasm-induced coronary artery region is associated with disease activity of vasospastic angina. J Am Coll Cardiol 28:460\u2013464","journal-title":"J Am Coll Cardiol"},{"key":"6_CR157_6","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1126\/science.2928797","volume":"243","author":"SP Saxena","year":"1989","unstructured":"Saxena SP, Brandes LJ, Becker AB, Simons KJ, LaBella FS, Gerrard JM (1989) Histamine is an intracellular messenger mediating platelet aggregation. Science 243:1596\u20131599","journal-title":"Science"},{"key":"6_CR158_6","first-page":"841","volume":"492","author":"S Schaefer","year":"1996","unstructured":"Schaefer S, RA Valente, LJ Laslett, JC Longhurst (1996) Cardiac reflex effects of intracoronary bradykinin in humans. J Investig Med 492:841\u2013850","journal-title":"J Investig Med"},{"key":"6_CR159_6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3940(97)00269-3","volume":"226","author":"M Schmelz","year":"1997","unstructured":"Schmelz M, Osiander G, Blunk J, Ringkamp M, Reeh PW, Handwerker HO (1997) Intracutaneous injections of platelets cause acute pain and protracted hyperalgesia. Neurosci Lett 226:171\u2013174","journal-title":"Neurosci Lett"},{"key":"6_CR160_6","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1152\/jappl.1990.68.5.2042","volume":"68","author":"H Shams","year":"1990","unstructured":"Shams H, Scheid P (1990) Effects of thromboxane on respiration and pulmonary circulation in the cat: role of vagus nerve. J Appl Physiol 68:2042\u20132046","journal-title":"J Appl Physiol"},{"key":"6_CR161_6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1385\/MN:30:2:117","volume":"30","author":"C Sommer","year":"2004","unstructured":"Sommer C (2004) Serotonin in pain and analgesia: actions in the periphery. Mol Neurobiol 30:117\u2013125","journal-title":"Mol Neurobiol"},{"key":"6_CR162_6","doi-asserted-by":"crossref","first-page":"H748","DOI":"10.1152\/ajpcell.1992.262.2.C427","volume":"262","author":"G Stahl","year":"1992","unstructured":"Stahl G, Longhurst J (1992) Ischemically sensitive visceral afferents: importance of H+ derived from lactic acid and hypercapnia. Am J Physiol 262:H748\u2013H753","journal-title":"Am J Physiol"},{"key":"6_CR163_6","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/01.RES.72.6.1266","volume":"72","author":"G Stahl","year":"1993","unstructured":"Stahl G, Pan H-L, Longhurst J (1993) Activation of ischemia and reperfusion-sensitive abdominal visceral C fiber afferents: role of hydrogen peroxide and hydroxyl radicals. Circ Res 72:1266\u20131275","journal-title":"Circ Res"},{"issue":"suppl E","key":"6_CR164_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/eurheartj\/11.suppl_E.3","volume":"11","author":"HC Stary","year":"1990","unstructured":"Stary HC (1990) The sequence of cell and matrix changes in atherosclerotic lesions of coronary arteries in the first forty years of life. Eur Heart J 11(suppl E):3\u201319","journal-title":"Eur Heart J"},{"key":"6_CR165_6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/cvr\/10.3.314","volume":"10","author":"J Staszewka-Barczak","year":"1976","unstructured":"Staszewka-Barczak J, Ferreira SH, Vane JR (1976) An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia. Cardiovasc Res 10:314\u2013327","journal-title":"Cardiovasc Res"},{"key":"6_CR166_6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/jphysiol.1989.sp017859","volume":"419","author":"J Staszewska-Woolley","year":"1989","unstructured":"Staszewska-Woolley J, Woolley G (1989) Participation of the kallikrein-kinin-receptor system in reflexes arising from neural afferents in the dog epicardium. J Physiol (Lond) 419:33\u201344","journal-title":"J Physiol (Lond)"},{"key":"6_CR167_6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1152\/jappl.1985.59.1.56","volume":"59","author":"CL Stebbins","year":"1985","unstructured":"Stebbins CL, Longhurst JC (1985) Bradykinin-induced chemoreflexes from skeletal muscle: implications for the exercise reflex. J Appl Physiol 59:56\u201363","journal-title":"J Appl Physiol"},{"key":"6_CR168_6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1152\/jappl.1986.61.1.271","volume":"61","author":"CL Stebbins","year":"1986","unstructured":"Stebbins CL, Longhurst JC (1986) Bradykinin in the reflex cardiovascular responses to static muscular contraction. J Appl Physiol 61:271\u2013279","journal-title":"J Appl Physiol"},{"key":"6_CR169_6","first-page":"H1098","volume":"261","author":"CL Stebbins","year":"1991","unstructured":"Stebbins CL, Theodossy SJ, Longhurst JC (1991) Cardiovascular reflexes evoked by histamine stimulation of the stomach. Am J Physiol 261:H1098\u2013H1105","journal-title":"Am J Physiol"},{"key":"6_CR170_6","first-page":"R112","volume":"262","author":"C Stebbins","year":"1992","unstructured":"Stebbins C, Stahl G, Theodossy S, Longhurst J (1992) Modulation of bradykinin-induced gastric-cardiovascular reflexes by histamine. Am J Physiol 262:R112\u2013R119","journal-title":"Am J Physiol"},{"key":"6_CR171_6","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1523\/JNEUROSCI.15-05-03982.1995","volume":"15","author":"KH Steen","year":"1995","unstructured":"Steen KH, Steen AE, Reeh PW (1995) A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vivo. J Neurosci 15:3982\u20133989","journal-title":"J Neurosci"},{"key":"6_CR172_6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0049-3848(84)90230-5","volume":"35","author":"K Stegmeier","year":"1984","unstructured":"Stegmeier K, Pill J, Muller-Beckmann B, Schmidt FH, Witte EC, Wolff HP, Patscheke H (1984) The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. Thromb Res 35:379\u2013395","journal-title":"Thromb Res"},{"key":"6_CR173_6","first-page":"3","volume-title":"Platelet responses and metabolism","author":"H Stormorken","year":"1986","unstructured":"Stormorken H (1986) Platelets in hemostasis and thrombosis. In: Holmsen H (ed) Platelet responses and metabolism, vol 1. CRC, Boca Raton, pp 3\u201332"},{"key":"6_CR174_6","doi-asserted-by":"crossref","first-page":"H93","DOI":"10.1152\/ajpheart.2001.281.1.H93","volume":"281","author":"SY Sun","year":"2001","unstructured":"Sun SY, Wang W, Schultz HD (2001) Activation of cardiac afferents by arachidonic acid: relative contributions of metabolic pathways. Am J Physiol Heart Circ Physiol 281:H93\u2013H104","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"6_CR175_6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/bmj.293.6541.227","volume":"293","author":"C Sylven","year":"1986","unstructured":"Sylven C, Beemann B, Jonzon B, Brandt R (1986) Angina pectoris-like pain provoked by intravenous adenosine. Br Med J 293:227\u2013230","journal-title":"Br Med J"},{"key":"6_CR176_6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0306-4522(91)90255-M","volume":"44","author":"YO Taiwo","year":"1991","unstructured":"Taiwo YO, Levine JD (1991) Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neuroscience 44:131\u2013135","journal-title":"Neuroscience"},{"key":"6_CR177_6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0306-4522(92)90508-Y","volume":"48","author":"YO Taiwo","year":"1992","unstructured":"Taiwo YO, Levine JD (1992) Serotonin is a directly-acting hyperalgesic agent in the rat. Neuroscience 48:485\u2013490","journal-title":"Neuroscience"},{"key":"6_CR178_6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-8993(87)90858-4","volume":"423","author":"Y Taiwo","year":"1987","unstructured":"Taiwo Y, Goetzl EJ, Levine JD (1987) Hyperalgesia onset latency suggests a hierarchy of action. Brain Res 423:333\u2013337","journal-title":"Brain Res"},{"key":"6_CR179_6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1748-1716.1973.tb05430.x","volume":"88","author":"P Thoren","year":"1973","unstructured":"Thoren P (1973) Evidence for a depressor reflex elicited from left ventricular receptors during occlusion of one coronary artery in the cat. Acta Physiol Scand 88:23\u201334","journal-title":"Acta Physiol Scand"},{"key":"6_CR180_6","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/0002-9149(76)90422-7","volume":"37","author":"PN Thoren","year":"1976","unstructured":"Thoren PN (1976) Activation of left ventricular receptors with nonmedullated vagal afferent fibers during occlusion of a coronary artery in the cat. Am J Cardiol 37:1046\u20131051","journal-title":"Am J Cardiol"},{"key":"6_CR181_6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1469-7793.1998.633bk.x","volume":"510","author":"S Tjen-A-Looi","year":"1998","unstructured":"Tjen-A-Looi S, H-L Pan, JC Longhurst (1998) Endogenous bradykinin activates ischaemically sensitive cardiac visceral afferents through kinin B2 receptors in cats. J Physiol (Lond) 510:633\u2013641","journal-title":"J Physiol (Lond)"},{"key":"6_CR182_6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1113\/jphysiol.2001.013482","volume":"543","author":"S Tjen-A-Looi","year":"2002","unstructured":"Tjen-A-Looi S, Fu L-W, Longhurst JC (2002) Xanthine oxidase, but not neutrophils, contribute to activation of cardiac sympathetic afferents during myocardial ischaemia in cats. J Physiol (Lond) 543:327\u2013336","journal-title":"J Physiol (Lond)"},{"key":"6_CR183_6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0306-4522(89)90018-3","volume":"28","author":"T Tokimasa","year":"1989","unstructured":"Tokimasa T, Akasu T (1989) Histamine H2 receptor mediates postsynaptic excitation and presynaptic inhibition in submucous plexus neurons of the guinea-pig. Neuroscience 28:735\u2013744","journal-title":"Neuroscience"},{"key":"6_CR184_6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1536\/ihj.15.84","volume":"15","author":"Y Uchida","year":"1974","unstructured":"Uchida Y, Murao S (1974) Bradykinin-induced excitation of afferent cardiac sympathetic nerve fibers. Jpn Heart J 15:84\u201391","journal-title":"Jpn Heart J"},{"key":"6_CR185_6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1152\/ajplegacy.1975.228.1.27","volume":"228","author":"Y Uchida","year":"1975","unstructured":"Uchida Y, Murao S (1975) Acid-induced excitation of afferent cardiac sympathetic nerve fibers. Am J Physiol 228:27\u201333","journal-title":"Am J Physiol"},{"key":"6_CR186_6","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/01.RES.74.5.904","volume":"74","author":"EE Ustinova","year":"1994","unstructured":"Ustinova EE, Schultz HD (1994) Activation of cardiac vagal afferents in ischemia and reperfusion: prostaglandins vs. oxygen free radicals. Circ Res 74:904\u2013911","journal-title":"Circ Res"},{"key":"6_CR187_6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.CIR.79.1.116","volume":"79","author":"EK Van den Berg","year":"1989","unstructured":"Van den Berg EK, Schmitz JM, Benedict CR, Malloy CR, Willerson JT, Dehmer GJ (1989) Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology. Circulation 79:116\u2013124","journal-title":"Circulation"},{"key":"6_CR188_6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0952-3278(97)90497-X","volume":"57","author":"GJ Van der Vusse","year":"1997","unstructured":"Van der Vusse GJ, Reneman RS, van Bilsen M (1997) Accumulation of arachidonic acid in ischemic\/reperfused cardiac tissue: possible causes and consequences. Prostaglandins Leukot Essent Fatty Acids 57:85\u201393","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"6_CR189_6","first-page":"771","volume":"221","author":"AJM Verhoeven","year":"1984","unstructured":"Verhoeven AJM, Mommersteeg ME, Akkerman JWN (1984) Quantification of energy consumption in platelets during thrombin-induced aggregation and secretion. Biochem J 221:771\u2013787","journal-title":"Biochem J"},{"key":"6_CR190_6","doi-asserted-by":"crossref","first-page":"H482","DOI":"10.1152\/ajpheart.00624.2001","volume":"282","author":"MJ Wacker","year":"2002","unstructured":"Wacker MJ, Tehrani RN, Smoot RL, Orr JA (2002) Thromboxane A2 mimetic evokes a bradycardia mediated by stimulation of cardiac vagal afferent nerves. Am J Physiol Heart Circ Physiol 282:H482\u2013H490","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"6_CR191_6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2005.05.066","volume":"386","author":"MJ Wacker","year":"2005","unstructured":"Wacker MJ, Tyburski JB, Ammar CP, Adams MC, Orr JA (2005) Detection of thromboxane A2 receptor mRNA in rabbit nodose ganglion neurons. Neurosci Lett 386:121\u2013126","journal-title":"Neurosci Lett"},{"key":"6_CR192_6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/01.CIR.16.4.644","volume":"16","author":"JC White","year":"1957","unstructured":"White JC (1957) Cardiac pain: anatomic pathway and physiologic mechanisms. Circulation 16:644\u2013655","journal-title":"Circulation"},{"key":"6_CR193_6","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.CIR.82.5.1595","volume":"82","author":"RF Wilson","year":"1990","unstructured":"Wilson RF, Wyche K, Christensen BV, Zimmer S, Laxson DD (1990) Effects of adenosine on human coronary arterial circulation. Circulation 82:1595\u20131606","journal-title":"Circulation"},{"key":"6_CR194_6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF01965035","volume":"25","author":"AA Wolff","year":"1988","unstructured":"Wolff AA, Levi R (1988) Ventricular arrhythmias parallel cardiac histamine efflux after coronary artery occlusion in the dog. Agents Actions 25:296\u2013306","journal-title":"Agents Actions"},{"issue":"2","key":"6_CR195_6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1113\/jphysiol.2003.048207","volume":"551","author":"MR Zahner","year":"2003","unstructured":"Zahner MR, Li D-P, Chen S-R, Pan H-L (2003) Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol (Lond) 551(2):515\u2013523","journal-title":"J Physiol (Lond)"},{"key":"6_CR196_6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/01.RES.47.4.509","volume":"47","author":"IH Zucker","year":"1980","unstructured":"Zucker IH, Cornish KG (1980) Reflex cardiovascular and respiratory effects of serotonin in conscious and anesthetized dogs. Circ Res 47:509\u2013515","journal-title":"Circ Res"},{"key":"6_CR197_6","doi-asserted-by":"crossref","first-page":"24156","DOI":"10.1016\/S0021-9258(19)51062-6","volume":"269","author":"J Zweier","year":"1994","unstructured":"Zweier J, Broderick R, Kuppusamy P, Thompson-Gorman S, Lutty GA (1994) Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. J Biol Chem 269:24156\u201324162","journal-title":"J Biol Chem"}],"container-title":["Handbook of Experimental Pharmacology","Sensory Nerves"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-540-79090-7_6.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T16:42:09Z","timestamp":1739292129000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-540-79090-7_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"ISBN":["9783540790891","9783540790907"],"references-count":197,"URL":"https:\/\/doi.org\/10.1007\/978-3-540-79090-7_6","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}