{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:19:28Z","timestamp":1790623168272,"version":"4.1.0"},"publisher-location":"Berlin, Heidelberg","reference-count":112,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642004766","type":"print"},{"value":"9783642004773","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"DOI":"10.1007\/978-3-642-00477-3_6","type":"book-chapter","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T10:54:00Z","timestamp":1266404040000},"page":"171-192","source":"Crossref","is-referenced-by-count":24,"title":["Pulmonary Drug Delivery: Medicines for Inhalation"],"prefix":"10.1007","author":[{"given":"Andreas","family":"Henning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Hein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus-Michael","family":"Lehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,11,19]]},"reference":[{"key":"6_CR1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0928-0987(01)00147-6","volume":"14","author":"R Abu-Dahab","year":"2001","unstructured":"Abu-Dahab R, Schafer UF, Lehr C-M (2001) Lectin-functionalized liposomes for pulmonary drug delivery: effect of nebulization on stability and bioadhesion. Eur J Pharm Sci 14:37\u201346","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"6_CR2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/jam.1990.3.85","volume":"3","author":"JM Aiache","year":"1990","unstructured":"Aiache JM (1990) Aerosol therapy in France. J Aerosol Med 3:85\u2013120","journal-title":"J Aerosol Med"},{"key":"6_CR3","first-page":"3","volume-title":"Textbook of respiratory medicine","author":"KH Albertine","year":"2000","unstructured":"Albertine KH, Williams MC, Hyde DM (2000) Anatomy and development of the respiratory tract. In: Murray JF, Nadel JA (eds) Textbook of respiratory medicine. W.B. Saunders CBS Educ. and Professional Publ, New York, NY, pp 3\u201333"},{"key":"6_CR4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0005-2736(91)90201-I","volume":"1068","author":"TM Allen","year":"1991","unstructured":"Allen TM, Hansen C (1991) Pharmacokinetics of stealth versus conventional liposomes: effect of dose. BBA Biomembranes 1068:133\u2013141","journal-title":"BBA Biomembranes"},{"key":"6_CR5","doi-asserted-by":"crossref","first-page":"6818","DOI":"10.1016\/j.vaccine.2007.05.064","volume":"25","author":"M Amidi","year":"2007","unstructured":"Amidi M, Pellikaan HC, Hirschberg H, de Boer AH, Crommelin DJA, Hennink WE, Kersten G, Jiskoot W (2007) Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs. Vaccine 25:6818\u20136829","journal-title":"Vaccine"},{"key":"6_CR6","doi-asserted-by":"crossref","first-page":"8707","DOI":"10.1016\/j.vaccine.2007.10.035","volume":"25","author":"JP Amorij","year":"2007","unstructured":"Amorij JP, Saluja V, Petersen AH, Hinrichs WLJ, Huckriede A, Frijlink HW (2007) Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB\/c mice. Vaccine 25:8707\u20138717","journal-title":"Vaccine"},{"key":"6_CR7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ejps.2006.07.004","volume":"29","author":"S Anabousi","year":"2006","unstructured":"Anabousi S, Bakowsky U, Schneider M, Huwer H, Lehr CM, Ehrhardt C (2006a) In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer. Eur J Pharm Sci 29:367\u2013374","journal-title":"Eur J Pharm Sci"},{"key":"6_CR8","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1166\/jnn.2006.461","volume":"6","author":"S Anabousi","year":"2006","unstructured":"Anabousi S, Kleemann E, Bakowsky U, Kissel T, Schmehl T, Gessler T, Seeger W, Lehr CM, Ehrhardt G (2006b) Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant. J Nanosci Nanotechnol 6:3010\u20133016","journal-title":"J Nanosci Nanotechnol"},{"key":"6_CR9","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1080\/10611860601010314","volume":"14","author":"V Arya","year":"2006","unstructured":"Arya V, Coowanitwong I, Brugos B, Kim WS, Singh R, Hochhaus G (2006) Pulmonary targeting of sustained release formulation of budesonide in neonatal rats. J Drug Target 14:680\u2013686","journal-title":"J Drug Target"},{"key":"6_CR10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/rpd\/ncm249","volume":"127","author":"MR Bailey","year":"2007","unstructured":"Bailey MR, Ansoborlo E, Guilmette RA, Paquet F (2007) Updating the ICRP human respiratory tract model. Radiat Prot Dosim 127:31\u201334","journal-title":"Radiat Prot Dosim"},{"key":"6_CR11","volume-title":"Pulmonary drug delivery \u2013 basics, applications and opportunities for small molecules and biopharmaceutics","year":"2007","unstructured":"Bechtold-Peters K, Luessen H (eds) (2007) Pulmonary drug delivery \u2013 basics, applications and opportunities for small molecules and biopharmaceutics. Editio Cantor Verlag, Aulendorf, Germany"},{"issue":"5","key":"6_CR12","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/jps.21553","volume":"98","author":"J Beisner","year":"2008","unstructured":"Beisner J, Dong M, Taetz S, Piotrowska K, Kleideiter E, Friedel G, Schaefer U, Lehr CM, Klotz U, M\u00fcrdter TE (2008) Efficient telomerase inhibition in human non-small cell lung cancer cells by liposomal delivery of 2\u2019-O-methyl-RNA. J Pharm Sci 98:1765\u20131774","journal-title":"J Pharm Sci"},{"key":"6_CR13","first-page":"1","volume-title":"Theatri tabidorum vestibulum: seu exercitationes dianoeticae cum historiis et experimentis demonstratives","author":"C Bennet","year":"1654","unstructured":"Bennet C (1654) Theatri tabidorum vestibulum: seu exercitationes dianoeticae cum historiis et experimentis demonstratives. Newcomb, London, pp 1\u2013126"},{"key":"6_CR14","first-page":"806","volume":"80","author":"JV Bennett","year":"2002","unstructured":"Bennett JV, De Castro JF, Valdespino-Gomez JL, De Lourdes Garcia-Garcia M, Islas-Romero R, Echaniz-Aviles G, Jimenez-Corona A, Sepulveda-Amor J (2002) Aerosolized measles and measles-rubella vaccines induce better measles antibody booster responses than injected vaccines: randomized trials in Mexican school children. Bull World Health Organ 80:806\u2013812","journal-title":"Bull World Health Organ"},{"key":"6_CR15","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1152\/jappl.1999.86.1.168","volume":"86","author":"WD Bennett","year":"1999","unstructured":"Bennett WD, Scheuch G, Zeman KL, Brown JS, Kim C, Heyder J, Stahlhofen W (1999) Regional deposition and retention of particles in shallow, inhaled boluses: effect of lung volume. J Appl Physiol 86:168\u2013173","journal-title":"J Appl Physiol"},{"key":"6_CR16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/sj.gt.3302876","volume":"14","author":"SR Bhattarai","year":"2007","unstructured":"Bhattarai SR, Kim SY, Jang KY, Yi HK, Lee YH, Bhattarai N, Nam SY, Lee DY, Kim HY, Hwang PH (2007) Amphiphilic triblock copolymer poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol), enhancement of gene expression and inhibition of lung metastasis by aerosol delivery. Gene Ther 14:476\u2013483","journal-title":"Gene Ther"},{"key":"6_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2005.05.028","volume":"107","author":"M Bivas-Benita","year":"2005","unstructured":"Bivas-Benita M, Ottenhoff THM, Junginger HE, Borchard G (2005) Pulmonary DNA vaccination: concepts, possibilities and perspectives. J Control Release 107:1\u201329","journal-title":"J Controlled Release"},{"key":"6_CR18","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.vaccine.2003.09.044","volume":"22","author":"M Bivas-Benita","year":"2004","unstructured":"Bivas-Benita M, Van Meijgaarden KE, Franken KLMC, Junginger HE, Borchard G, Ottenhoff THM, Geluk A (2004) Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis. Vaccine 22:1609\u20131615","journal-title":"Vaccine"},{"key":"6_CR19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1368-504X.2005.00725.x","volume":"59","author":"R Booker","year":"2005","unstructured":"Booker R (2005) Do patients think that dry powder inhalers can be used interchangeably? Int J Clin Prac 59:30\u201332","journal-title":"Int J Clin Prac"},{"key":"6_CR20","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/(SICI)1520-6017(200006)89:6<724::AID-JPS3>3.0.CO;2-B","volume":"89","author":"P Brand","year":"2000","unstructured":"Brand P, Friemel I, Meyer T, Schulz H, Heyder J, Huinger K (2000) Total deposition of therapeutic particles during spontaneous and controlled inhalations. J Pharm Sci 89:724\u2013731","journal-title":"J Pharm Sci"},{"key":"6_CR21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/jam.2004.17.239","volume":"17","author":"JS Brown","year":"2004","unstructured":"Brown JS, Bennett WD (2004) Deposition of coarse particles in cystic fibrosis: model predictions versus experimental results. J Aerosol Med 17:239\u2013248","journal-title":"J Aerosol Med"},{"key":"6_CR22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/10611860108997933","volume":"9","author":"A Brueck","year":"2001","unstructured":"Brueck A, Abu-Dahab R, Borchard G, Schaefer UF, Lehr CM (2001) Lectin-functionalized liposomes for pulmonary drug delivery: interaction with human alveolar epithelial cells. J Drug Target 9:241\u2013251","journal-title":"J Drug Target"},{"key":"6_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jamp.2007.0657","volume":"21","author":"JL Burger","year":"2008","unstructured":"Burger JL, Cape SP, Braun CS, McAdams DH, Best JA, Bhagwat P, Pathak P, Rebits LG, Sievers RE (2008) Stabilizing formulations for inhalable powders of live-attenuated measles virus vaccine. J Aerosol Med 21:1\u201310","journal-title":"J Aerosol Med"},{"key":"6_CR24","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1080\/10611860701637974","volume":"15","author":"T Chen","year":"2007","unstructured":"Chen T, Wang Z, Wang R, Lu T, Wang W (2007) Polyethylenimine \u2013 DNA solid particles for gene delivery. J Drug Target 15:714\u2013720","journal-title":"J Drug Target"},{"key":"6_CR25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jaerosci.2008.02.002","volume":"39","author":"H Chiou","year":"2008","unstructured":"Chiou H, Chan HK, Heng D, Prud\u2019homme RK, Raper JA (2008) A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation. J Aerosol Sci 39:500\u2013509","journal-title":"J Aerosol Sci"},{"key":"6_CR26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jconrel.2007.12.011","volume":"127","author":"S Chono","year":"2008","unstructured":"Chono S, Tanino T, Seki T, Morimoto K (2008) Efficient drug targeting to rat alveolar macrophages by pulmonary administration of ciprofloxacin incorporated into mannosylated liposomes for treatment of respiratory intracellular parasitic infections. J Control Release 127:50\u201358","journal-title":"J Controlled Release"},{"key":"6_CR27","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.2217\/14622416.8.9.1191","volume":"8","author":"PE Cruz","year":"2007","unstructured":"Cruz PE, Mueller C, Flotte TR (2007) The promise of gene therapy for the treatment of \u03b1-1 antitrypsin deficiency. Pharmacogenomics 8:1191\u20131198","journal-title":"Pharmacogenomics"},{"key":"6_CR28","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.vaccine.2006.10.019","volume":"25","author":"RL Swart de","year":"2007","unstructured":"de Swart RL, Li Calsi C, Quirk AV, van Amerongen G, Nodelman V, Alcock R, Yuksel S, Ward GH, Hardy JG, Vos H, Witham CL, Grainger CI, Kuiken T, Greenspan BJ, Gard TG, Osterhaus ADME (2007) Measles vaccination of macaques by dry powder inhalation. Vaccine 25:1183\u20131190","journal-title":"Vaccine"},{"key":"6_CR29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-4165(96)00088-8","volume":"1334","author":"P Deol","year":"1997","unstructured":"Deol P, Khuller GK (1997) Lung specific stealth liposomes: stability, biodistribution and toxicity of liposomal antitubercular drugs in mice. BBA-Gen Subjects 1334:161\u2013172","journal-title":"BBA-Gen Subjects"},{"key":"6_CR30","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1128\/AAC.41.6.1211","volume":"41","author":"P Deol","year":"1997","unstructured":"Deol P, Khuller GK, Joshi K (1997) Therapeutic efficacies of isoniazid and rifampin encapsulated in lung-specific stealth liposomes against Mycobacterium tuberculosis infection induced in mice. Antimicrob Agents Chemother 41:1211\u20131214","journal-title":"Antimicrob Agents Chemother"},{"key":"6_CR31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/08942680152007918","volume":"14","author":"JF Dessanges","year":"2001","unstructured":"Dessanges JF (2001) A history of nebulization. J Aerosol Med 14:65\u201371","journal-title":"J Aerosol Med"},{"key":"6_CR32","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/oxfordjournals.molbev.a026400","volume":"17","author":"JL Desseyn","year":"2000","unstructured":"Desseyn JL, Aubert JP, Porchet N, Laine A (2000) Evolution of the large secreted gel-forming mucins. Mol Biol Evol 17:1175\u20131184","journal-title":"Mol Biol Evol"},{"key":"6_CR33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/jam.2005.18.261","volume":"18","author":"R Dhand","year":"2005","unstructured":"Dhand R (2005) Aerosol plumes: slow and steady wins the race. J Aerosol Med 18:261\u2013263","journal-title":"J Aerosol Med"},{"key":"6_CR34","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1016\/j.vaccine.2007.03.003","volume":"25","author":"A Dilraj","year":"2007","unstructured":"Dilraj A, Sukhoo R, Cutts FT, Bennett JV (2007) Aerosol and subcutaneous measles vaccine: measles antibody responses 6 years after re-vaccination. Vaccine 25:4170\u20134174","journal-title":"Vaccine"},{"key":"6_CR35","first-page":"589","volume":"45","author":"MA Dolovich","year":"2000","unstructured":"Dolovich MA, MacIntyre NR, Anderson PJ, Camargo CA Jr, Chew N, Cole CH, Dhand R, Fink JB, Gross NJ, Hess DR, Hickey AJ, Kim CS, Martonen TB, Pierson DJ, Rubin BK, Smaldone GC (2000) Consensus statement: aerosols and delivery devices. Respir Care 45:589\u2013596","journal-title":"Respir Care"},{"key":"6_CR36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2174\/156652307782793504","volume":"7","author":"R Eager","year":"2007","unstructured":"Eager R, Harle L, Nemunaitis JJ (2007) Lung cancer vaccines. Curr Gene Ther 7:469\u2013484","journal-title":"Curr Gene Ther"},{"key":"6_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2003.09.013","volume":"94","author":"A El-Aneed","year":"2004","unstructured":"El-Aneed A (2004) An overview of current delivery systems in cancer gene therapy. J Control Release 94:1\u201314","journal-title":"J Controlled Release"},{"key":"6_CR38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejpb.2005.02.010","volume":"60","author":"B Forbes","year":"2005","unstructured":"Forbes B, Ehrhardt C (2005) Human respiratory epithelial cell culture for drug delivery applications. Eur J Pharma Biopharm 60:193\u2013205","journal-title":"Eur J Pharma Biopharm"},{"key":"6_CR39","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1166\/jnn.2006.426","volume":"6","author":"NN Gaber","year":"2006","unstructured":"Gaber NN, Darwis Y, Peh KK, Tan YTF (2006) Characterization of polymeric micelles for pulmonary delivery of beclomethasone dipropionate. J Nanosci Nanotechnol 6:3095\u20133101","journal-title":"J Nanosci Nanotechnol"},{"key":"6_CR40","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1128\/AAC.01164-06","volume":"51","author":"L Garcia-Contreras","year":"2007","unstructured":"Garcia-Contreras L, Fiegel J, Telko MJ, Elbert K, Hawi A, Thomas M, VerBerkmoes J, Germishuizen WA, Fourie PB, Hickey AJ, Edwards DA (2007) Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrob Agents Chemother 51:2830\u20132836","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"6_CR41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1208\/pt0804081","volume":"8","author":"RJ Garmise","year":"2007","unstructured":"Garmise RJ, Staats HF, Hickey AJ (2007) Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination. AAPS PharmSciTech 8:81","journal-title":"AAPS PharmSciTech"},{"key":"6_CR42","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1289\/ehp.8006","volume":"113","author":"M Geiser","year":"2005","unstructured":"Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P (2005) Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555\u20131560","journal-title":"Environ Health Perspect"},{"key":"6_CR43","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1164\/ajrccm.156.6.9702101","volume":"156","author":"BE Gilbert","year":"1997","unstructured":"Gilbert BE, Knight C, Alvarez FG, Waldrep JC, Rodarte JR, Knight V, Eschenbacher WL (1997) Tolerance of volunteers to cyclosporine A-dilauroylphosphatidylcholine liposome aerosol. Am J Respir Crit Care Med 156:1789\u20131793","journal-title":"Am J Respir Crit Care Med"},{"key":"6_CR44","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1200\/JCO.2005.04.937","volume":"23","author":"WJ Gradishar","year":"2005","unstructured":"Gradishar WJ, Tjulandin S, Davidson N, Shaw H, Desai N, Bhar P, Hawkins M, O\u2019Shaughnessy J (2005) Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 23:7794\u20137803","journal-title":"J Clin Oncol"},{"key":"6_CR45","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1053\/rmed.2002.1457","volume":"97","author":"DA Groneberg","year":"2003","unstructured":"Groneberg DA, Witt C, Wagner U, Chung KF, Fischer A (2003) Fundamentals of pulmonary drug delivery. Respir Med 97:382\u2013387","journal-title":"Respir Med"},{"key":"6_CR46","first-page":"820","volume":"80","author":"J Heyder","year":"1981","unstructured":"Heyder J (1981) Mechanisms of aerosol particle deposition. Chest 80:820\u2013823","journal-title":"Chest"},{"key":"6_CR47","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0021-8502(86)90035-2","volume":"17","author":"J Heyder","year":"1986","unstructured":"Heyder J, Gebhart J, Rudolf G, Schiller CF, Stahlhofen W (1986) Deposition of particles in the human respiratory tract in the size range 0.005\u201315 \u00b5m. J Aerosol Sci 17:811\u2013825","journal-title":"J Aerosol Sci"},{"key":"6_CR48","first-page":"21","volume-title":"Drug delivery to the lung","author":"J Heyder","year":"2002","unstructured":"Heyder J, Svartengren MU (2002) Basic principles of particle behavior in the human respiratory tract. In: Bisgaard H, O\u2019Callaghan C, Smaldone GC (eds) Drug delivery to the lung. New York, Marcel Dekker, pp 21\u201345"},{"key":"6_CR49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jconrel.2007.01.013","volume":"119","author":"K Hirota","year":"2007","unstructured":"Hirota K, Hasegawa T, Hinata H, Ito F, Inagawa H, Kochi C, Soma GI, Makino K, Terada H (2007) Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages. J Control Release 119:69\u201376","journal-title":"J Controlled Release"},{"key":"6_CR50","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/jps.20591","volume":"95","author":"CJ Hitzman","year":"2006","unstructured":"Hitzman CJ, Elmquist WF, Wattenberg LW, Wiedmann TS (2006a) Development of a respirable, sustained release microcarrier for 5-fluorouracil I: In vitro assessment of liposomes, microspheres, and lipid coated nanoparticles. J Pharm Sci 95:1114\u20131126","journal-title":"J Pharm Sci"},{"key":"6_CR51","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/jps.20590","volume":"95","author":"CJ Hitzman","year":"2006","unstructured":"Hitzman CJ, Elmquist WF, Wiedmann TS (2006b) Development of a respirable, sustained release microcarrier for 5-fluorouracil II: In vitro and in vivo optimization of lipid coated nanoparticles. J Pharm Sci 95:1127\u20131143","journal-title":"J Pharm Sci"},{"key":"6_CR52","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/jps.20607","volume":"95","author":"CJ Hitzman","year":"2006","unstructured":"Hitzman CJ, Wattenberg LW, Wiedmann TS (2006c) Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles. J Pharm Sci 95:1196\u20131211","journal-title":"J Pharm Sci"},{"key":"6_CR53","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/jnci\/87.12.895","volume":"87","author":"K Hiyama","year":"1995","unstructured":"Hiyama K, Hiyama E, Ishioka S, Yamakido M, Inai K, Gazdar AF, Piatyszek MA, Shay JW (1995) Telomerase activity in small-cell and non-small-cell lung cancers. J Natl Cancer Inst 87:895\u2013902","journal-title":"J Natl Cancer Inst"},{"key":"6_CR54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1046-2023(03)00139-7","volume":"31","author":"P Hobson","year":"2003","unstructured":"Hobson P, Barnfield C, Barnes A, Klavinskis LS (2003) Mucosal immunization with DNA vaccines. Methods 31:217\u2013224","journal-title":"Methods"},{"key":"6_CR55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/jam.2005.18.273","volume":"18","author":"D Hochrainer","year":"2005","unstructured":"Hochrainer D, Holz H, Kreher C, Scaffidi L, Spallek M, Wachtel H (2005) Comparison of the aerosol velocity and spray duration of Respimat\u00ae Soft Mist\u2122 inhaler and pressurized metered dose inhalers. J Aerosol Med 18:273\u2013282","journal-title":"J Aerosol Med"},{"key":"6_CR56","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ymthe.2006.04.010","volume":"14","author":"KA Howard","year":"2006","unstructured":"Howard KA, Rahbek UL, Liu X, Damgaard CK, Glud SZ, Andersen M\u00d8, Hovgaard MB, Schmitz A, Nyengaard JR, Besenbacher F, Kjems J (2006) RNA Interference in vitro and in vivo using a novel chitosan\/siRNA nanoparticle system. Mol Ther 14:476\u2013484","journal-title":"Mol Ther"},{"key":"6_CR57","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1164\/ajrccm.155.5.9154878","volume":"155","author":"AT Iacono","year":"1997","unstructured":"Iacono AT, Smaldone GC, Keenan RJ, Diot P, Dauber JH, Zeevi A, Burckart GJ, Griffith BP (1997) Dose-related reversal of acute lung rejection by aerosolized cyclosporine. Am J Respir Crit Care Med 155:1690\u20131698","journal-title":"Am J Respir Crit Care Med"},{"key":"6_CR58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/014664539402401-303","volume":"24","author":"ICRP","year":"1994","unstructured":"ICRP (1994) Human respiratory tract model for radiological protection. Ann ICRP 24:1\u2013120","journal-title":"Ann ICRP"},{"key":"6_CR59","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jconrel.2006.06.029","volume":"115","author":"MM Issa","year":"2006","unstructured":"Issa MM, K\u00f6ping-H\u00f6gg\u00e5rd M, T\u00f8mmeraas K, V\u00e5rum KM, Christensen BE, Strand SP, Artursson P (2006) Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo. J Control Release 115:103\u2013112","journal-title":"J Controlled Release"},{"key":"6_CR60","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejpb.2006.07.006","volume":"65","author":"S Jaspart","year":"2007","unstructured":"Jaspart S, Bertholet P, Piel G, Dogne JM, Delattre L, Evrard B (2007) Solid lipid microparticles as a sustained release system for pulmonary drug delivery. Eur J Pharm Biopharm 65:47\u201356","journal-title":"Eur J Pharm Biopharm"},{"key":"6_CR61","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jconrel.2004.09.005","volume":"100","author":"E Kleemann","year":"2004","unstructured":"Kleemann E, Dailey LA, Abdelhady HG, Gessler T, Schmehl T, Roberts CJ, Davies MC, Seeger W, Kissel T (2004) Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy: Investigations of the complex structure and stability during air-jet and ultrasonic nebulization. J Control Release 100:437\u2013450","journal-title":"J Controlled Release"},{"key":"6_CR62","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jconrel.2005.09.036","volume":"109","author":"E Kleemann","year":"2005","unstructured":"Kleemann E, Neu M, Jekel N, Fink L, Schmehl T, Gessler T, Seeger W, Kissel T (2005) Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J Control Release 109:299\u2013316","journal-title":"J Controlled Release"},{"key":"6_CR63","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/sj.gt.3302312","volume":"11","author":"M K\u00f6ping-H\u00f6gg\u00e5rd","year":"2004","unstructured":"K\u00f6ping-H\u00f6gg\u00e5rd M, Varum KM, Issa M, Danielsen S, Christensen BE, Stokke BT, Artursson P (2004) Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther 11:1441\u20131452","journal-title":"Gene Ther"},{"key":"6_CR64","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1073\/pnas.0608611104","volume":"104","author":"SK Lai","year":"2007","unstructured":"Lai SK, O\u2019Hanlon DE, Harrold S, Man ST, Wang YY, Cone R, Hanes J (2007) Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci USA 104:1482\u20131487","journal-title":"Proc Natl Acad Sci USA"},{"key":"6_CR65","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejpb.2007.04.017","volume":"68","author":"TP Learoyd","year":"2008","unstructured":"Learoyd TP, Burrows JL, French E, Seville PC (2008) Chitosan-based spray-dried respirable powders for sustained delivery of terbutaline sulfate. Eur J Pharm Biopharm 68:224\u2013234","journal-title":"Eur J Pharm Biopharm"},{"key":"6_CR66","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-5173(92)90353-4","volume":"78","author":"C-M Lehr","year":"1992","unstructured":"Lehr C-M, Bouwstra JA, Schacht EH, Junginger HE (1992) In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int J Pharm 78:43\u201348","journal-title":"Int J Pharm"},{"key":"6_CR67","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1089\/jam.2006.19.372","volume":"19","author":"YK Lentz","year":"2006","unstructured":"Lentz YK, Anchordoquy TJ, Lengsfeld CS (2006) Rationale for the selection of an aerosol delivery system for gene delivery. J Aerosol Med 19:372\u2013384","journal-title":"J Aerosol Med"},{"key":"6_CR68","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/S0003-4975(99)01183-2","volume":"68","author":"GV Letsou","year":"1999","unstructured":"Letsou GV, Safi HJ, Reardon MJ, Ergenoglu M, Li Z, Klonaris CN, Baldwin JC, Gilbert BE, Waldrep JC (1999) Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression. Ann Thorac Surg 68:2044\u20132048","journal-title":"Ann Thorac Surg"},{"key":"6_CR69","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s11095-006-0027-x","volume":"23","author":"HY Li","year":"2006","unstructured":"Li HY, Birchall J (2006) Chitosan-modified dry powder formulations for pulmonary gene delivery. Pharm Res 23:941\u2013950","journal-title":"Pharm Res"},{"key":"6_CR70","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/S0264-410X(00)00503-X","volume":"19","author":"C LiCalsi","year":"2001","unstructured":"LiCalsi C, Maniaci MJ, Christensen T, Phillips E, Ward GH, Witham C (2001) A powder formulation of measles vaccine for aerosol delivery. Vaccine 19:2629\u20132636","journal-title":"Vaccine"},{"key":"6_CR71","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1586\/14760584.6.2.213","volume":"6","author":"D Lu","year":"2007","unstructured":"Lu D, Hickey AJ (2007) Pulmonary vaccine delivery. Expert Rev Vaccines 6:213\u2013226","journal-title":"Expert Rev Vaccines"},{"key":"6_CR72","doi-asserted-by":"crossref","first-page":"342","DOI":"10.5414\/ATP31342","volume":"31","author":"W Moeller","year":"2005","unstructured":"M\u00f6ller W, H\u00e4u\u00dfinger K, Kreyling WG, Scheuch G (2005) Particle clearance from the human respiratory tract. Atemw-Lungenkrkh 31:342\u2013351","journal-title":"Atemwegs- und Lungenkrankheiten"},{"key":"6_CR73","first-page":"1","volume-title":"A radical and expeditious cure for a recent catarrhous cough","author":"J Mudge","year":"1778","unstructured":"Mudge J (1778) A radical and expeditious cure for a recent catarrhous cough. Allen, London, pp 1\u2013252"},{"key":"6_CR74","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2141.2007.06942.x","volume":"140","author":"SL Murphy","year":"2008","unstructured":"Murphy SL, High KA (2008) Gene therapy for haemophilia. Br J Haematol 140:479\u2013487","journal-title":"Br J Haematol"},{"key":"6_CR75","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.nano.2007.03.006","volume":"3","author":"N Nafee","year":"2007","unstructured":"Nafee N, Taetz S, Schneider M, Schaefer UF, Lehr CM (2007) Chitosan-coated PLGA nanoparticles for DNA\/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides. Nanomedicine 3:173\u2013183","journal-title":"Nanomedicine"},{"key":"6_CR76","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1164\/ajrccm.151.2.7842214","volume":"151","author":"TG O\u2019Riordan","year":"1995","unstructured":"O\u2019Riordan TG, Iacono A, Keenan RJ, Duncan SR, Burckart GJ, Griffith BP, Smaldone GC (1995) Delivery and distribution of aerosolized cyclosporine in lung allograft recipients. Am J Respir Crit Care Med 151:516\u2013521","journal-title":"Am J Respir Crit Care Med"},{"key":"6_CR77","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1289\/ehp.7339","volume":"113","author":"G Oberd\u00f6rster","year":"2005","unstructured":"Oberd\u00f6rster G, Oberd\u00f6rster E, Oberd\u00f6rster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823\u2013839","journal-title":"Environ Health Perspect"},{"key":"6_CR78","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/jac\/dkg477","volume":"52","author":"R Pandey","year":"2003","unstructured":"Pandey R, Sharma A, Zahoor A, Sharma S, Khuller GK, Prasad B (2003) Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis. J Antimicrob Chemother 52:981\u2013986","journal-title":"J Antimicrob Chemother"},{"key":"6_CR79","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrd2153","volume":"6","author":"JS Patton","year":"2007","unstructured":"Patton JS, Byron PR (2007) Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6:67\u201374","journal-title":"Nat Rev Drug Discov"},{"key":"6_CR80","unstructured":"Perkins W, Weers J, Meers P (2005) An inhalation formulation of liposomal cisplatin (SLITTM Cisplatin) for treatment of lung cancer [abstract]. In: Conference Vancouver: Lipids, Liposomes & Biomembranes"},{"key":"6_CR81","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s11095-006-9789-4","volume":"23","author":"G Pilcer","year":"2006","unstructured":"Pilcer G, Sebti T, Amighi K (2006) Formulation and characterization of lipid-coated tobramycin particles for dry powder inhalation. Pharm Res 23:931\u2013940","journal-title":"Pharm Res"},{"key":"6_CR82","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1089\/jam.2005.18.264","volume":"18","author":"G Pitcairn","year":"2005","unstructured":"Pitcairn G, Reader S, Pavia D, Newman S (2005) Deposition of corticosteroid aerosol in the human lung by Respimat\u00ae Soft Mist\u2122 inhaler compared to deposition by metered dose inhaler or by Turbuhaler\u00ae dry powder inhaler. J Aerosol Med 18:264\u2013272","journal-title":"J Aerosol Med"},{"key":"6_CR83","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.biomaterials.2003.08.069","volume":"25","author":"MNV Ravi Kumar","year":"2004","unstructured":"Ravi Kumar MNV, Bakowsky U, Lehr CM (2004) Preparation and characterization of cationic PLGA nanospheres as DNA carriers. Biomaterials 25:1771\u20131777","journal-title":"Biomaterials"},{"key":"6_CR84","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1016\/j.vaccine.2005.04.021","volume":"23","author":"RC Read","year":"2005","unstructured":"Read RC, Naylor SC, Potter CW, Bond J, Jabbal-Gill I, Fisher A, Illum L, Jennings R (2005) Effective nasal influenza vaccine delivery using chitosan. Vaccine 23:4367\u20134374","journal-title":"Vaccine"},{"key":"6_CR85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(98)00398-6","volume":"181","author":"M Saari","year":"1999","unstructured":"Saari M, Vidgren MT, Koskinen MO, Turjanmaa VMH, Nieminen MM (1999) Pulmonary distribution and clearance of two beclomethasone liposome formulations in healthy volunteers. Int J Pharm 181:1\u20139","journal-title":"Int J Pharm"},{"key":"6_CR86","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3132\/pcrj.2007.00017","volume":"16","author":"M Sanders","year":"2007","unstructured":"Sanders M (2007) Inhalation therapy: an historical review. Prim Care Respir J 16:71\u201381","journal-title":"Prim Care Respir J"},{"issue":"2","key":"6_CR87","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1208\/pt050227","volume":"5","author":"V Sanna","year":"2004","unstructured":"Sanna V, Kirschvink N, Gustin P, Gavini E, Roland I, Delattre L, Evrard B (2004) Preparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration. AAPS PharmSciTech 5(2):27","journal-title":"AAPS PharmSciTech"},{"key":"6_CR88","first-page":"39","volume":"79","author":"G Scheuch","year":"2008","unstructured":"Scheuch G, Fischer A (2008) Improved entry into the airways. Manuf Chem Aerosol News 79:39\u201340","journal-title":"Manuf Chem Aerosol News"},{"key":"6_CR89","first-page":"615","volume":"58","author":"G Scheuch","year":"2007","unstructured":"Scheuch G, Siekmeier R (2007) Novel approaches to enhance pulmonary delivery of proteins and peptides. J Physiol Pharmacol 58:615\u2013625","journal-title":"J Physiol Pharmacol"},{"key":"6_CR90","first-page":"46","volume-title":"Pulmonary drug delivery: basiscs, applications, and opportunities for small molecules and biopharmaceutics","author":"G Scheuch","year":"2007","unstructured":"Scheuch G, Zimlich WC, Siekmeier R (2007) Biophysical parameters determining pulmonary drug delivery. In: Bechthold-Peters K, Luessen H (eds) Pulmonary drug delivery: basiscs, applications, and opportunities for small molecules and biopharmaceutics. Editio Cantor Verlag, Aulendorf, pp 46\u201354"},{"key":"6_CR91","first-page":"255","volume":"21","author":"K Selting","year":"2008","unstructured":"Selting K, Waldrep JC, Reinero C, Branson K, Gustafson D, Kim DY, Henry C, Owen N, Madsen R, Dhand R (2008) Feasibility and safety of targeted cisplatin delivery to a select lung lobe in dogs via the AeroProbe\u00ae. J Aerosol Med Pulm Drug Deliv 21:255\u2013268","journal-title":"Icorp Neb Cath"},{"key":"6_CR92","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/08942680252908584","volume":"15","author":"J Serra-Batlles","year":"2002","unstructured":"Serra-Batlles J, Plaza V, Badiola C, Morejon E, Bardagi S, Brotons B, Cabello F, Castillo JA, Hermida JA, Lopez-Vinas A, Marin JM, Tabar A (2002) Patient perception and acceptability of multidose dry powder inhalers: a randomized crossover comparison of Diskus\/Accuhaler with Turbuhaler. J Aerosol Med 15:59\u201364","journal-title":"J Aerosol Med"},{"key":"6_CR93","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/jac\/dkh411","volume":"54","author":"A Sharma","year":"2004","unstructured":"Sharma A, Sharma S, Khuller GK (2004) Lectin-functionalized poly (lactide-co-glycolide) nanoparticles as oral\/aerosolized antitubercular drug carriers for treatment of tuberculosis. J Antimicrob Chemother 54:761\u2013766","journal-title":"J Antimicrob Chemother"},{"key":"6_CR94","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrd2081","volume":"5","author":"JW Shay","year":"2006","unstructured":"Shay JW, Wright WE (2006) Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov 5:577\u2013584","journal-title":"Nat Rev Drug Discov"},{"key":"6_CR95","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1164\/ajrccm\/141.2.471","volume":"141","author":"Y Sibille","year":"1990","unstructured":"Sibille Y, Reynolds HY (1990) Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 141:471\u2013501","journal-title":"Am Rev Respir Dis"},{"key":"6_CR96","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.ejpb.2008.01.037","volume":"69","author":"P Sinswat","year":"2008","unstructured":"Sinswat P, Overhoff KA, McConville JT, Johnston KP, Williams Iii RO (2008) Nebulization of nanoparticulate amorphous or crystalline tacrolimus \u2013 single-dose pharmacokinetics study in mice. Eur J Pharm Biopharm 69:1057\u20131066","journal-title":"Eur J Pharm Biopharm"},{"key":"6_CR97","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1016\/S0264-410X(03)00224-X","volume":"21","author":"DJ Smith","year":"2003","unstructured":"Smith DJ, Bot S, Dellamary L, Bot A (2003) Evaluation of novel aerosol formulations designed for mucosal vaccination against influenza virus. Vaccine 21:2805\u20132812","journal-title":"Vaccine"},{"key":"6_CR98","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ccm.2007.02.004","volume":"28","author":"V Sueblinvong","year":"2007","unstructured":"Sueblinvong V, Suratt BT, Weiss DJ (2007) Novel therapies for the treatment of cystic fibrosis: new developments in gene and stem cell therapy. Clin Chest Med 28:361\u2013379","journal-title":"Clin Chest Med"},{"issue":"2","key":"6_CR99","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ejpb.2008.07.011","volume":"72","author":"S Taetz","year":"2009","unstructured":"Taetz S, Nafee N, Beisner J, Piotrowska K, Baldes C, M\u00fcrdter TE, Huwer H, Schneider M, Schaefer UF, Klotz U, Lehr CM (2009) The influence of chitosan content in cationic chitosan\/PLGA nanoparticles on the delivery efficiency of antisense 2\u2032-O-methyl-RNA directed against telomerase in lung cancer cells. Eur J Pharm Biopharm 72:358\u2013369","journal-title":"Eur J Pharm Biopharm"},{"key":"6_CR100","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/mt.2008.38","volume":"16","author":"AD Tagalakis","year":"2008","unstructured":"Tagalakis AD, McAnulty RJ, Devaney J, Bottoms SE, Wong JB, Elbs M, Writer MJ, Hailes HC, Tabor AB, O\u2019Callaghan C, Jaffe A, Hart SL (2008) A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer. Mol Ther 16:907\u2013915","journal-title":"Mol Ther"},{"key":"6_CR101","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1248\/yakushi.127.1541","volume":"127","author":"K Tahara","year":"2007","unstructured":"Tahara K, Yamamoto H, Takeuchi H, Kawashima Y (2007) Development of gene delivery system using PLGA nanospheres. Yakugaku Zasshi 127:1541\u20131548","journal-title":"Yakugaku Zasshi"},{"key":"6_CR102","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10717540801952530","volume":"15","author":"M Takenaga","year":"2008","unstructured":"Takenaga M, Ohta Y, Tokura Y, Hamaguchi A, Igarashi R, Disratthakit A, Doi N (2008) Lipid microsphere formulation containing rifampicin targets alveolar macrophages. Drug Deliv 15:169\u2013175","journal-title":"Drug Deliv"},{"key":"6_CR103","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.physiol.70.113006.100702","volume":"70","author":"DJ Thornton","year":"2008","unstructured":"Thornton DJ, Rousseau K, McGuckin MA (2008) Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 70:459\u2013486","journal-title":"Annu Rev Physiol"},{"key":"6_CR104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000028109","volume":"68","author":"T Tschernig","year":"2000","unstructured":"Tschernig T, Pabst R (2000) Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases. Pathobiology 68:1\u20138","journal-title":"Pathobiology"},{"key":"6_CR105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejpb.2007.05.011","volume":"68","author":"CA Ventura","year":"2008","unstructured":"Ventura CA, Tommasini S, Crupi E, Giannone I, Cardile V, Musumeci T, Puglisi G (2008) Chitosan microspheres for intrapulmonary administration of moxifloxacin: interaction with biomembrane models and in vitro permeation studies. Eur J Pharm Biopharm 68:235\u2013244","journal-title":"Eur J Pharm Biopharm"},{"key":"6_CR106","volume-title":"Morphometry of the human lung","year":"1963","unstructured":"Weibel ER (ed) (1963) Morphometry of the human lung. Academic Press, New York"},{"key":"6_CR107","first-page":"999","volume":"15","author":"ER Weibel","year":"1979","unstructured":"Weibel ER (1979) Morphometry of the human lung: the state of the art after two decades. Clin Respir Physiol 15:999\u20131013","journal-title":"Clin Respir Physiol"},{"key":"6_CR108","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/0894268041457174","volume":"17","author":"MJ Welch","year":"2004","unstructured":"Welch MJ, Nelson HS, Shapiro G, Bensch GW, Sokol WN, Smith JA, Parasuraman BM (2004) Comparison of patient preference and ease of teaching inhaler technique for Pulmicort Turbuhaler\u00ae versus pressurized metered-dose inhalers. J Aerosol Med 17:129\u2013139","journal-title":"J Aerosol Med"},{"key":"6_CR109","unstructured":"WHO (2008) \n                    http:\/\/www.who.int\/tb\/publications\/global_report\/2008\/summary\/en\/index.html\n                    \n                  ."},{"key":"6_CR110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jconrel.2007.10.011","volume":"125","author":"W Wijagkanalan","year":"2008","unstructured":"Wijagkanalan W, Kawakami S, Takenaga M, Igarashi R, Yamashita F, Hashida M (2008) Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats. J Control Release 125:121\u2013130","journal-title":"J Controlled Release"},{"key":"6_CR111","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1158\/1078-0432.CCR-06-1480","volume":"13","author":"BPH Wittgen","year":"2007","unstructured":"Wittgen BPH, Kunst PWA, Van Der Born K, Van Wijk AW, Perkins W, Pilkiewicz FG, Perez-Soler R, Nicholson S, Peters GJ, Postmus PE (2007) Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung. Clin Cancer Res 13:2414\u20132421","journal-title":"Clin Cancer Res"},{"key":"6_CR112","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ejpb.2007.04.005","volume":"67","author":"M Zaru","year":"2007","unstructured":"Zaru M, Mourtas S, Klepetsanis P, Fadda AM, Antimisiaris SG (2007) Liposomes for drug delivery to the lungs by nebulization. Eur J Pharm Biopharm 67:655\u2013666","journal-title":"Eur J Pharm Biopharm"}],"container-title":["Handbook of Experimental Pharmacology","Drug Delivery"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-00477-3_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T04:02:13Z","timestamp":1558843333000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-00477-3_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,19]]},"ISBN":["9783642004766","9783642004773"],"references-count":112,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-00477-3_6","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,19]]}}}