{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T10:08:07Z","timestamp":1725530887608},"publisher-location":"Berlin, Heidelberg","reference-count":28,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783642007262"},{"type":"electronic","value":"9783642007279"}],"license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"DOI":"10.1007\/978-3-642-00727-9_20","type":"book-chapter","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:45:52Z","timestamp":1240274752000},"page":"199-210","source":"Crossref","is-referenced-by-count":3,"title":["Deciphering Drug Action and Escape Pathways: An\u00a0Example\u00a0on\u00a0Nasopharyngeal\u00a0Carcinoma"],"prefix":"10.1007","author":[{"given":"Difeng","family":"Dong","sequence":"first","affiliation":[]},{"given":"Chun-Ying","family":"Cui","sequence":"additional","affiliation":[]},{"given":"Benjamin","family":"Mow","sequence":"additional","affiliation":[]},{"given":"Limsoon","family":"Wong","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"20_CR1","first-page":"4484","volume":"105","author":"A. Alvi","year":"2005","unstructured":"Alvi, A., Austen, B., Weston, V., et al.: A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-independent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival. al\u00a0105, 4484\u20134491 (2005)","journal-title":"al"},{"issue":"1","key":"20_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/gb-2003-4-1-r7","volume":"4","author":"S.W. Doniger","year":"2003","unstructured":"Doniger, S.W., Salomonis, N., Dahlquist, K.D., et al.: MAPPFinder: Using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biology\u00a04(1), R7 (2003)","journal-title":"Genome Biology"},{"issue":"10","key":"20_CR3","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1101\/gr.6202607","volume":"17","author":"S. Draghici","year":"2007","unstructured":"Draghici, S., Khatri, P., Tarca, A., et al.: A systems biology approach for pathway level analysis. Genome Research\u00a017(10), 1537\u20131545 (2007)","journal-title":"Genome Research"},{"key":"20_CR4","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1093\/bioinformatics\/btm294","volume":"23","author":"Z. Guo","year":"2007","unstructured":"Guo, Z., Li, Y., Gong, X., et al.: Edge-based scoring and searching method for identifying condition-responsive protein-protein interaction sub-network. Bioinformatics\u00a023, 2121\u20132128 (2007)","journal-title":"Bioinformatics"},{"key":"20_CR5","unstructured":"Herrington, H.: Controlling the false discovery rate in multiple hypothesis testing, http:\/\/www.unt.edu\/benchmarks\/archives\/2002\/april02\/rss.htm"},{"issue":"suppl. 1","key":"20_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/bioinformatics\/18.suppl_1.S233","volume":"18","author":"T. Ideker","year":"2002","unstructured":"Ideker, T., Ozier, O., Schwikowski, B., Siegel, A.F.: Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics\u00a018(suppl. 1), S233\u2013S240 (2002)","journal-title":"Bioinformatics"},{"issue":"1","key":"20_CR7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/nar\/30.1.42","volume":"30","author":"M. Kanehisa","year":"2002","unstructured":"Kanehisa, M., Goto, S., Kawashima, S., Nakaya, A.: The KEGG database at GenomeNet. Nucleic Acids Research\u00a030(1), 42\u201346 (2002)","journal-title":"Nucleic Acids Research"},{"key":"20_CR8","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1093\/annonc\/mdi217","volume":"16","author":"K. Lacrima","year":"2005","unstructured":"Lacrima, K., Valentini, A., Lambertini, C., et al.: In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas. Annals of Oncology\u00a016, 1169\u20131176 (2005)","journal-title":"Annals of Oncology"},{"key":"20_CR9","doi-asserted-by":"crossref","unstructured":"Lam, L., Pickeral, O., Peng, A., et al.: Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biology\u00a02(10), research004 (2001)","DOI":"10.1186\/gb-2001-2-10-research0041"},{"key":"20_CR10","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/ijc.10738","volume":"102","author":"S. McClue","year":"2002","unstructured":"McClue, S., Blake, D., Clarke, R., et al.: In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-ROSCOVITINE). International Journal of Cancer\u00a0102, 463\u2013468 (2002)","journal-title":"International Journal of Cancer"},{"key":"20_CR11","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/j.1432-1033.1997.t01-2-00527.x","volume":"243","author":"L. Meijer","year":"1997","unstructured":"Meijer, L., Borgne, A., Mulner, O., et al.: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinase cdc2, cdk2 and cdk5. European Journal of Biochemistry\u00a0243, 527\u2013536 (1997)","journal-title":"European Journal of Biochemistry"},{"key":"20_CR12","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1056\/NEJM199509143331103","volume":"333","author":"R. Pathmanathan","year":"1995","unstructured":"Pathmanathan, R., Prasad, U., Sadler, R., et al.: Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. The New England Journal of Medicine\u00a0333, 693\u2013698 (1995)","journal-title":"The New England Journal of Medicine"},{"key":"20_CR13","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1056\/NEJM199808273390907","volume":"339","author":"C. Pui","year":"1998","unstructured":"Pui, C., Evans, W.: Acute lymphoblastic leukemia. New England Journal of Medicine\u00a0339, 605\u2013615 (1998)","journal-title":"New England Journal of Medicine"},{"key":"20_CR14","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1182\/blood-2005-01-0320","volume":"106","author":"N. Raje","year":"2005","unstructured":"Raje, N., Kumar, S., Hideshima, T., et al.: Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of MCL1 in multiple myeloma. Blood\u00a0106, 1042\u20131047 (2005)","journal-title":"Blood"},{"key":"20_CR15","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1002\/ijc.22107","volume":"119","author":"W. Shi","year":"2006","unstructured":"Shi, W., Bastianutto, C., Li, A., et al.: Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling. International Journal of Cancer\u00a0119, 2467\u20132475 (2006)","journal-title":"International Journal of Cancer"},{"key":"20_CR16","doi-asserted-by":"publisher","DOI":"10.1201\/9781420005400","volume-title":"Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents","author":"P. Smith","year":"2006","unstructured":"Smith, P., Yue, E.: Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents. Taylor and Francis Group, Abington (2006)"},{"key":"20_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1145\/1294301.1294306","volume":"9","author":"D. Soh","year":"2007","unstructured":"Soh, D., Dong, D., Guo, Y., Wong, L.: Enabling more sophisticated gene expression analysis for understanding diseases and optimizing treatments. ACM SIGKDD Explorations\u00a09, 3\u201314 (2007)","journal-title":"ACM SIGKDD Explorations"},{"key":"20_CR18","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A. Subramanian","year":"2005","unstructured":"Subramanian, A., Tamayo, P., Mootha, V., et al.: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Science of the United States of America\u00a0102, 15545\u201315550 (2005)","journal-title":"Proceedings of the National Academy of Science of the United States of America"},{"key":"20_CR19","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/S0360-3016(00)00702-1","volume":"48","author":"K. Sultanem","year":"2000","unstructured":"Sultanem, K., Shu, H.K., Xia, P., et al.: Three-dimensional intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: the University of California, San Francisco experience. International journal of radiation oncology, biology, physics\u00a048, 711\u2013722 (2000)","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"20_CR20","doi-asserted-by":"crossref","unstructured":"Tan, W., Dong, D., Loh, M., et al.: Pathway determinants of 5-Fluorouracil activity. Poster. In: 20th EORTC-NCI-AACR symposium on Molecular targets and Cancer Therapeutics (2008)","DOI":"10.1016\/S1359-6349(08)72129-3"},{"key":"20_CR21","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S1044579X02000901","volume":"12","author":"S. Tsao","year":"2002","unstructured":"Tsao, S., Tramoutanis, G., Dawson, C., et al.: The significance of LMP1 expression in nasopharyngeal carcinoma. Cancer Biology\u00a012, 473\u2013487 (2002)","journal-title":"Cancer Biology"},{"key":"20_CR22","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1158\/0008-5472.CAN-03-0110","volume":"64","author":"S. Whittaker","year":"2004","unstructured":"Whittaker, S., Walton, M., Garrett, M., Workman, P.: The cyclin-dependent kinase inhibitor CYC202 (R-Roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of cyclin D1, and activates the mitogen-activated protein kinase pathway. Cancer Research\u00a064, 262\u2013272 (2004)","journal-title":"Cancer Research"},{"key":"20_CR23","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S1535-6108(02)00032-6","volume":"1","author":"E. Yeoh","year":"2002","unstructured":"Yeoh, E., Ross, M., Shurtleff, S., et al.: Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell\u00a01, 133\u2013143 (2002)","journal-title":"Cancer Cell"},{"key":"20_CR24","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S1044579X02000858","volume":"12","author":"M. Yu","year":"2002","unstructured":"Yu, M., Yuan, J.: Epidemiology of nasopharyngeal carcinoma. Seminars in Cancer Biology\u00a012, 421\u2013429 (2002)","journal-title":"Seminars in Cancer Biology"},{"issue":"4","key":"20_CR25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/gb-2003-4-4-r28","volume":"4","author":"B.R. Zeeberg","year":"2003","unstructured":"Zeeberg, B.R., Feng, W., Wang, G., et al.: GoMiner: A resource for biological interpretation of genomic and proteomic data. Genome Biology\u00a04(4), R28 (2003)","journal-title":"Genome Biology"},{"key":"20_CR26","first-page":"407","volume":"8","author":"A. Zien","year":"2000","unstructured":"Zien, A., Kuffner, R., Zimmer, R., Lengauer, T.: Analysis of gene expression data with pathway scores. Proceedings of International Conference on Intelligent Systems for Molecular Biology\u00a08, 407\u2013417 (2000)","journal-title":"Proceedings of International Conference on Intelligent Systems for Molecular Biology"},{"key":"20_CR27","unstructured":"Pathway Ingenuity database, http:\/\/www.ingenuity.com\/"},{"key":"20_CR28","unstructured":"WikiPathways, http:\/\/www.wikipathways.org\/index.php\/WikiPathways"}],"container-title":["Lecture Notes in Computer Science","Bioinformatics and Computational Biology"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-00727-9_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T11:56:29Z","timestamp":1558266989000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-00727-9_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"ISBN":["9783642007262","9783642007279"],"references-count":28,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-00727-9_20","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2009]]}}}