{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:04:23Z","timestamp":1786979063978,"version":"build-2736575974"},"publisher-location":"Berlin, Heidelberg","reference-count":22,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642212598","type":"print"},{"value":"9783642212604","type":"electronic"}],"license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"DOI":"10.1007\/978-3-642-21260-4_6","type":"book-chapter","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T00:26:59Z","timestamp":1304036819000},"page":"12-24","source":"Crossref","is-referenced-by-count":31,"title":["Prediction of Essential Proteins by Integration of PPI Network Topology and Protein Complexes Information"],"prefix":"10.1007","author":[{"given":"Jun","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"6_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature01278","volume":"421","author":"R.S. Kamath","year":"2003","unstructured":"Kamath, R.S., Fraser, A.G., et al.: Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature\u00a0421, 231\u2013237 (2003)","journal-title":"Nature"},{"issue":"6841","key":"6_CR2","first-page":"1046","volume":"411","author":"C. Pal","year":"2003","unstructured":"Pal, C., Papp, B., Hurst, L.: Genomic function: Rate of evolution and gene dispensability. Nature\u00a0411(6841), 1046\u20131049 (2003)","journal-title":"Nature"},{"issue":"4","key":"6_CR3","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/molbev\/msi101","volume":"22","author":"J.Z. Zhang","year":"2005","unstructured":"Zhang, J.Z., He, X.L.: Significant impact of protein dispensability on the instantaneous rate of protein evolution. Mol. Biol. Evol.\u00a022(4), 1147\u20131155 (2005)","journal-title":"Mol. Biol. Evol."},{"issue":"5","key":"6_CR4","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1093\/nar\/gkh330","volume":"32","author":"F.A. Kondrashov","year":"2004","unstructured":"Kondrashov, F.A., Ogurtsov, A.Y., Kondrashov, A.S.: Bioinformatical assay of human gene morbidity. Nucl. Acids Res.\u00a032(5), 1731\u20131737 (2004)","journal-title":"Nucl. Acids Res."},{"key":"6_CR5","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1471-2164-7-165","volume":"7","author":"S.J. Furney","year":"2006","unstructured":"Furney, S.J., Alba, M.M., Lopez-Bigas, N.: Differencesin the evolutionary history of disease genes affected by dominantor recessive mutations. BMC Genomics\u00a07, 165 (2006)","journal-title":"BMC Genomics"},{"key":"6_CR6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/35075138","volume":"411","author":"H. Jeong","year":"2001","unstructured":"Jeong, H., Mason, S.P., Barabasi, A.L., Oltvai, Z.N.: Lethality and centrality in protein networks. Nature\u00a0411, 41\u201342 (2001)","journal-title":"Nature"},{"key":"6_CR7","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-3-642-13078-6_11","volume-title":"Bioinformatics Research and Applications","author":"M. Li","year":"2010","unstructured":"Li, M., Wang, J.X., Wang, H., Pan, Y.: Essential Proteins Discovery from Weighted Protein Interaction Networks. In: Borodovsky, M., Gogarten, J.P., Przytycka, T.M., Rajasekaran, S. (eds.) ISBRA 2010. LNCS, vol.\u00a06053, pp. 89\u2013100. Springer, Heidelberg (2010)"},{"issue":"6","key":"6_CR8","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1371\/journal.pgen.0020088","volume":"2","author":"X.L. He","year":"2006","unstructured":"He, X.L., Zhang, J.Z.: Why Do Hubs Tend to Be Essential in Protein Networks? PloS Genetics\u00a02(6), 826\u2013834 (2006)","journal-title":"PloS Genetics"},{"issue":"8","key":"6_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pcbi.1000140","volume":"4","author":"E. Zotenko","year":"2008","unstructured":"Zotenko, E., Mestre, J., O\u2019Leary, D.P., Przytycka, T.M.: Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality. PLoS Comput. Biol.\u00a04(8), 1\u201316 (2008)","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"6_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/pmic.200500209","volume":"6","author":"E. Ernesto","year":"2006","unstructured":"Ernesto, E.: Virtual identification of essential proteins within the protein interaction network of yeast. Proteomics\u00a06(1), 35\u201340 (2006)","journal-title":"Proteomics"},{"key":"6_CR11","doi-asserted-by":"crossref","unstructured":"Chua, H.N., Tew, K.L., Li, X.L., Ng, S.-K.: A Unified Scoring Scheme for Detecting Essential Proteins in Protein Interaction Networks. In: 20th ICTAI, vol.\u00a02, pp. 66\u201373 (2008)","DOI":"10.1109\/ICTAI.2008.107"},{"key":"6_CR12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/1471-2105-10-290","volume":"10","author":"M.L. Acencio","year":"2009","unstructured":"Acencio, M.L., Lemke, N.: Towards the prediction of essential genes by integration of nework topology, cellular localization and biological process information. BMC Bioinformatics\u00a010, 290 (2009)","journal-title":"BMC Bioinformatics"},{"key":"6_CR13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/1471-2105-8-236","volume":"8","author":"G.T. Hart","year":"2007","unstructured":"Hart, G.T., Lee, I., Marcotte, E.: A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality. BMC Bioinformatics\u00a08, 236 (2007)","journal-title":"BMC Bioinformatics"},{"issue":"15","key":"6_CR14","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1093\/bioinformatics\/btp311","volume":"25","author":"G.M. Liu","year":"2009","unstructured":"Liu, G.M., Wong, L., Chua, N.: Complex Discovery from Weighted PPI Networks. Bioinformatics\u00a025(15), 1891\u20131897 (2009)","journal-title":"Bioinformatics"},{"issue":"5569","key":"6_CR15","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1126\/science.1065103","volume":"296","author":"S. Maslov","year":"2002","unstructured":"Maslov, S., Sneppen, K.: Specificity and stability in topology of protein networks. Science\u00a0296(5569), 910\u2013913 (2002)","journal-title":"Science"},{"key":"6_CR16","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/978-3-540-31955-9_4","volume-title":"Network Analysis","author":"R. Jacob","year":"2005","unstructured":"Jacob, R., Koschtzki, D., Lehmann, K.A., et al.: Algorithms for Centrality Indices. In: Brandes, U., Erlebach, T. (eds.) Network Analysis. LNCS, vol.\u00a03418, pp. 62\u201382. Springer, Heidelberg (2005)"},{"issue":"2","key":"6_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1049\/iet-syb:20060038","volume":"1","author":"O. Mason","year":"2006","unstructured":"Mason, O., Verwoerd, M.: Graph theory and networks in biology. IET Systems Biology\u00a01(2), 89\u2013119 (2006)","journal-title":"IET Systems Biology"},{"issue":"5","key":"6_CR18","doi-asserted-by":"publisher","first-page":"56103","DOI":"10.1103\/PhysRevE.71.056103","volume":"71","author":"E. Estrada","year":"2005","unstructured":"Estrada, E., Rodr\u00edguez-Vel\u00e1zquez, J.: Subgraph centrality in complex networks. Phys. Rev. E.\u00a071(5), 056103 (2005)","journal-title":"Phys. Rev. E."},{"issue":"5663","key":"6_CR19","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1126\/science.1089167","volume":"303","author":"R. Milo","year":"2004","unstructured":"Milo, R., Itzkovitz, S., Kashtan, N., et al.: Superfamilies of designed and evolved networks. Science\u00a0303(5663), 1538\u20131542 (2004)","journal-title":"Science"},{"key":"6_CR20","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/nar\/30.1.303","volume":"30","author":"I. Xenarios","year":"2002","unstructured":"Xenarios, I., Salw\u00ednski, L., Duan, X.J., et al.: DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res.\u00a030, 303\u2013305 (2002)","journal-title":"Nucleic Acids Res."},{"key":"6_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/nar\/28.1.37","volume":"28","author":"H.W.. Mewes","year":"2000","unstructured":"Mewes, H.W., Frishman, D., Gruber, C., et al.: MIPS: a database for genomes and protein sequences. Nucleic Acids Res.\u00a028, 37\u201340 (2000)","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"6_CR22","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1073\/pnas.0400054101","volume":"101","author":"F. Radicchi","year":"2004","unstructured":"Radicchi, F., Castellano, C., Cecconi, F., et al.: Defining and identifying communities in networks. Proc. Natl. Acad. Sci. USA\u00a0101(9), 2658\u20132663 (2004)","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Lecture Notes in Computer Science","Bioinformatics Research and Applications"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-21260-4_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T01:44:25Z","timestamp":1558575865000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-21260-4_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"ISBN":["9783642212598","9783642212604"],"references-count":22,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-21260-4_6","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}