{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:13:58Z","timestamp":1791011638796,"version":"4.1.0"},"publisher-location":"Berlin, Heidelberg","reference-count":114,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642247156","type":"print"},{"value":"9783642247163","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-3-642-24716-3_17","type":"book-chapter","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T12:20:09Z","timestamp":1326716409000},"page":"357-381","source":"Crossref","is-referenced-by-count":57,"title":["Central and Peripheral Cannabinoid Receptors as Therapeutic Targets in the Control of Food Intake and Body Weight"],"prefix":"10.1007","author":[{"given":"Stefan","family":"Engeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,10]]},"reference":[{"key":"17_CR1_17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0091-6773(75)91684-3","volume":"15","author":"EL Abel","year":"1975","unstructured":"Abel EL (1975) Cannabis: effects on hunger and thirst. Behav Biol 15:255\u2013281","journal-title":"Behav Biol"},{"key":"17_CR2_17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/3-540-26573-2_3","volume":"168","author":"ME Abood","year":"2005","unstructured":"Abood ME (2005) Molecular biology of cannabinoid receptors. Handb Exp Pharmacol 168:81\u2013115","journal-title":"Handb Exp Pharmacol"},{"key":"17_CR3_17","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.cmet.2007.11.012","volume":"7","author":"C Addy","year":"2008","unstructured":"Addy C, Wright H, van Laere K, Gantz I, Erondu N, Musser BJ, Lu K, Yuan J, Sanabria-Bohorquez SM, Stoch A, Stevens C, Fong TM, De Lepeleire I, Cilissen C, Cote J, Rosko K, Gendrano IN III, Nguyen AM, Gumbiner B, Rothenberg P, de Hoon J, Bormans G, Depre M, Eng WS, Ravussin E, Klein S, Blundell J, Herman GA, Burns HD, Hargreaves RJ, Wagner J, Gottesdiener K, Amatruda JM, Heymsfield SB (2008) The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake. Cell Metab 7:68\u201378","journal-title":"Cell Metab"},{"key":"17_CR4_17","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1365-2036.2010.04259.x","volume":"31","author":"K Ameloot","year":"2010","unstructured":"Ameloot K, Janssen P, Scarpellini E, Vos R, Boesmans W, Depoortere I, Vanden BP, Tack J (2010) Endocannabinoid control of gastric sensorimotor function in man. Aliment Pharmacol Ther 31:1123\u20131131","journal-title":"Aliment Pharmacol Ther"},{"key":"17_CR5_17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s002130050326","volume":"132","author":"M Arnone","year":"1997","unstructured":"Arnone M, Maruani J, Chaperon F, Thiebot MH, Poncelet M, Soubrie P, Le Fur G (1997) Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology (Berl) 132:104\u2013106","journal-title":"Psychopharmacology (Berl)"},{"key":"17_CR6_17","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/ijo.2010.21","volume":"34","author":"LJ Aronne","year":"2010","unstructured":"Aronne LJ, Tonstad S, Moreno M, Gantz I, Erondu N, Suryawanshi S, Molony C, Sieberts S, Nayee J, Meehan AG, Shapiro D, Heymsfield SB, Kaufman KD, Amatruda JM (2010) A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study. Int J Obes (Lond) 34:919\u2013935","journal-title":"Int J Obes (Lond)"},{"key":"17_CR7_17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0885-3924(97)00038-9","volume":"14","author":"JE Beal","year":"1997","unstructured":"Beal JE, Olson R, Lefkowitz L, Laubenstein L, Bellman P, Yangco B, Morales JO, Murphy R, Powderly W, Plasse TF, Mosdell KW, Shepard KV (1997) Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. J Pain Symptom Manage 14:7\u201314","journal-title":"J Pain Symptom Manage"},{"key":"17_CR8_17","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00213-010-1995-4","volume":"212","author":"G Bedi","year":"2010","unstructured":"Bedi G, Foltin RW, Gunderson EW, Rabkin J, Hart CL, Comer SD, Vosburg SK, Haney M (2010) Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study. Psychopharmacology (Berl) 212:675\u2013686","journal-title":"Psychopharmacology (Berl)"},{"key":"17_CR9_17","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1124\/mol.63.4.908","volume":"63","author":"M Bensaid","year":"2003","unstructured":"Bensaid M, Gary-Bobo M, Esclangon A, Maffrand JP, Le Fur G, Oury-Donat F, Soubrie P (2003) The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa\/fa rats and in cultured adipocyte cells. Mol Pharmacol 63:908\u2013914","journal-title":"Mol Pharmacol"},{"key":"17_CR10_17","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.2337\/db06-0812","volume":"55","author":"M Bl\u00fcher","year":"2006","unstructured":"Bl\u00fcher M, Engeli S, Kl\u00f6ting N, Berndt J, Fasshauer M, Batkai S, Pacher P, Sch\u00f6n MR, Jordan J, Stumvoll M (2006) Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes 55:3053\u20133060","journal-title":"Diabetes"},{"key":"17_CR11_17","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1523\/JNEUROSCI.5404-03.2004","volume":"24","author":"G Burdyga","year":"2004","unstructured":"Burdyga G, Lal S, Varro A, Dimaline R, Thompson DG, Dockray GJ (2004) Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci 24:2708\u20132715","journal-title":"J Neurosci"},{"key":"17_CR12_17","doi-asserted-by":"publisher","first-page":"G1289","DOI":"10.1152\/ajpgi.00543.2005","volume":"290","author":"G Burdyga","year":"2006","unstructured":"Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ (2006) Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance. Am J Physiol Gastrointest Liver Physiol 290:G1289\u2013G1297","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"17_CR13_17","doi-asserted-by":"publisher","first-page":"G63","DOI":"10.1152\/ajpgi.00059.2010","volume":"299","author":"G Burdyga","year":"2010","unstructured":"Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ (2010) Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol 299:G63\u2013G69","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"17_CR14_17","doi-asserted-by":"publisher","first-page":"9800","DOI":"10.1073\/pnas.0703472104","volume":"104","author":"HD Burns","year":"2007","unstructured":"Burns HD, van Laere K, Sanabria-Bohorquez S, Hamill TG, Bormans G, Eng WS, Gibson R, Ryan C, Connolly B, Patel S, Krause S, Vanko A, van Hecken A, Dupont P, De Lepeleire I, Rothenberg P, Stoch SA, Cote J, Hagmann WK, Jewell JP, Lin LS, Liu P, Goulet MT, Gottesdiener K, Wagner JA, de Hoon J, Mortelmans L, Fong TM, Hargreaves RJ (2007) [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. Proc Natl Acad Sci U S A 104:9800\u20139805","journal-title":"Proc Natl Acad Sci U S A"},{"key":"17_CR15_17","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1079\/BJN20041256","volume":"92","author":"PD Cani","year":"2004","unstructured":"Cani PD, Montoya ML, Neyrinck AM, Delzenne NM, Lambert DM (2004) Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide. Br J Nutr 92:757\u2013761","journal-title":"Br J Nutr"},{"key":"17_CR16_17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1527-3458.2006.00091.x","volume":"12","author":"MA Carai","year":"2006","unstructured":"Carai MA, Colombo G, Maccioni P, Gessa GL (2006) Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data. CNS Drug Rev 12:91\u201399","journal-title":"CNS Drug Rev"},{"key":"17_CR17_17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mce.2006.12.038","volume":"267","author":"P Cavuoto","year":"2007","unstructured":"Cavuoto P, McAinch AJ, Hatzinikolas G, Cameron-Smith D, Wittert GA (2007) Effects of cannabinoid receptors on skeletal muscle oxidative pathways. Mol Cell Endocrinol 267:63\u201369","journal-title":"Mol Cell Endocrinol"},{"key":"17_CR18_17","doi-asserted-by":"publisher","first-page":"L113","DOI":"10.1016\/S0024-3205(98)00322-1","volume":"63","author":"G Colombo","year":"1998","unstructured":"Colombo G, Agabio R, Diaz G, Lobina C, Reali R, Gessa GL (1998) Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci 63:L113\u2013L117","journal-title":"Life Sci"},{"key":"17_CR19_17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1172\/JCI17725","volume":"112","author":"D Cota","year":"2003","unstructured":"Cota D, Marsicano G, Tsch\u00f6p M, Grubler Y, Flachskamm C, Schubert M, Auer D, Yassouridis A, Th\u00f6ne-Reineke C, Ortmann S, Tomassoni F, Cervino C, Nisoli E, Linthorst AC, Pasquali R, Lutz B, Stalla GK, Pagotto U (2003) The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 112:423\u2013431","journal-title":"J Clin Invest"},{"key":"17_CR20_17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/sj.ijo.0803539","volume":"31","author":"M Cot\u00e9","year":"2007","unstructured":"Cot\u00e9 M, Matias I, Lemieux I, Petrosino S, Almeras N, Despr\u00e9s JP, Di Marzo V (2007) Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. Int J Obes (Lond) 31:692\u2013699","journal-title":"Int J Obes (Lond)"},{"key":"17_CR21_17","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1056\/NEJMoa044537","volume":"353","author":"JP Despr\u00e9s","year":"2005","unstructured":"Despr\u00e9s JP, Golay A, Sj\u00f6str\u00f6m L (2005) Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353:2121\u20132134","journal-title":"N Engl J Med"},{"key":"17_CR22_17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0026-895X(25)09876-1","volume":"34","author":"WA Devane","year":"1988","unstructured":"Devane WA, Dysarz FA III, Johnson MR, Melvin LS, Howlett AC (1988) Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34:605\u2013613","journal-title":"Mol Pharmacol"},{"key":"17_CR23_17","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1126\/science.1470919","volume":"258","author":"WA Devane","year":"1992","unstructured":"Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946\u20131949","journal-title":"Science"},{"key":"17_CR24_17","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/35071088","volume":"410","author":"V Marzo Di","year":"2001","unstructured":"Di Marzo V, Goparaju SK, Wang L, Liu J, Batkai S, Jarai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, Kunos G (2001) Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410:822\u2013825","journal-title":"Nature"},{"key":"17_CR25_17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/3-540-26573-2_5","volume":"168","author":"V Marzo Di","year":"2005","unstructured":"Di Marzo V, De Petrocellis L, Bisogno T (2005) The biosynthesis, fate and pharmacological properties of endocannabinoids. Handb Exp Pharmacol 168:147\u2013185","journal-title":"Handb Exp Pharmacol"},{"key":"17_CR26_17","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1038\/sj.bjp.0707682","volume":"153","author":"V Marzo Di","year":"2008","unstructured":"Di Marzo V, Capasso R, Matias I, Aviello G, Petrosino S, Borrelli F, Romano B, Orlando P, Capasso F, Izzo AA (2008) The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet. Br J Pharmacol 153:1272\u20131280","journal-title":"Br J Pharmacol"},{"key":"17_CR27_17","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1530\/EJE-09-0643","volume":"161","author":"V Marzo Di","year":"2009","unstructured":"Di Marzo V, Verrijken A, Hakkarainen A, Petrosino S, Mertens I, Lundbom N, Piscitelli F, Westerbacka J, Soro-Paavonen A, Matias I, Van GL, Taskinen MR (2009a) Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. Eur J Endocrinol 161:715\u2013722","journal-title":"Eur J Endocrinol"},{"key":"17_CR28_17","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00125-008-1178-6","volume":"52","author":"V Marzo Di","year":"2009","unstructured":"Di Marzo V, Cot\u00e9 M, Matias I, Lemieux I, Arsenault BJ, Cartier A, Piscitelli F, Petrosino S, Almeras N, Despr\u00e9s JP (2009b) Changes in plasma endocannabinoid levels in viscerally obese men following a 1\u00a0year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors. Diabetologia 52:213\u2013217","journal-title":"Diabetologia"},{"key":"17_CR29_17","doi-asserted-by":"publisher","first-page":"R1409","DOI":"10.1152\/ajpregu.90484.2008","volume":"295","author":"NV Dipatrizio","year":"2008","unstructured":"Dipatrizio NV, Simansky KJ (2008) Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors. Am J Physiol Regul Integr Comp Physiol 295:R1409\u2013R1414","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"Suppl 1","key":"17_CR30_17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1365-2826.2008.01683.x","volume":"20","author":"S Engeli","year":"2008","unstructured":"Engeli S (2008a) Dysregulation of the endocannabinoid system in obesity. J Neuroendocrinol 20(Suppl 1):110\u2013115","journal-title":"J Neuroendocrinol"},{"key":"17_CR31_17","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000114255","volume":"1","author":"S Engeli","year":"2008","unstructured":"Engeli S (2008b) Peripheral metabolic effects of endocannabinoids and cannabinoid receptor blockade. Obes Facts 1:8\u201315","journal-title":"Obes Facts"},{"key":"17_CR32_17","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.2337\/diabetes.54.10.2838","volume":"54","author":"S Engeli","year":"2005","unstructured":"Engeli S, B\u00f6hnke J, Feldpausch M, Gorzelniak K, Janke J, Batkai S, Pacher P, Harvey-White J, Luft FC, Sharma AM, Jordan J (2005) Activation of the peripheral endocannabinoid system in human obesity. Diabetes 54:2838\u20132843","journal-title":"Diabetes"},{"key":"17_CR33_17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0195-6663(88)80017-5","volume":"11","author":"RW Foltin","year":"1988","unstructured":"Foltin RW, Fischman MW, Byrne MF (1988) Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite 11:1\u201314","journal-title":"Appetite"},{"key":"17_CR34_17","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/ijo.2009.132","volume":"33","author":"TM Fong","year":"2009","unstructured":"Fong TM, Heymsfield SB (2009) Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions. Int J Obes (Lond) 33:947\u2013955","journal-title":"Int J Obes (Lond)"},{"key":"17_CR35_17","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1124\/jpet.106.118737","volume":"321","author":"TM Fong","year":"2007","unstructured":"Fong TM, Guan XM, Marsh DJ, Shen CP, Stribling DS, Rosko KM, Lao J, Yu H, Feng Y, Xiao JC, Van der Ploeg LH, Goulet MT, Hagmann WK, Lin LS, Lanza TJ Jr, Jewell JP, Liu P, Shah SK, Qi H, Tong X, Wang J, Xu SS, Francis B, Strack AM, MacIntyre DE, Shearman LP (2007) Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(t rifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents. J Pharmacol Exp Ther 321:1013\u20131022","journal-title":"J Pharmacol Exp Ther"},{"key":"17_CR36_17","first-page":"914","volume":"104","author":"MA Gagnon","year":"1975","unstructured":"Gagnon MA, Elie R (1975) Effects of marijuana and D-amphetamine on the appetite, food consumption and various cardio-respiratory variables in man. Union Med Can 104:914\u2013921","journal-title":"Union Med Can"},{"key":"17_CR37_17","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1021\/ja01062a046","volume":"86","author":"Y Gaoni","year":"1964","unstructured":"Gaoni Y, Mechoulam R (1964) Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 86:1646","journal-title":"J Am Chem Soc"},{"key":"17_CR38_17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/hep.21641","volume":"46","author":"M Gary-Bobo","year":"2007","unstructured":"Gary-Bobo M, Elachouri G, Gallas JF, Janiak P, Marini P, Ravinet Trillou C, Chabbert M, Cruccioli N, Pfersdorff C, Roque C, Arnone M, Croci T, Soubrie P, Oury-Donat F, Maffrand JP, Scatton B, Lacheretz F, Le Fur G, Herbert JM, Bensaid M (2007) Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa\/fa rats. Hepatology 46:122\u2013129","journal-title":"Hepatology"},{"key":"17_CR39_17","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.1523\/JNEUROSCI.22-21-09612.2002","volume":"22","author":"R Gomez","year":"2002","unstructured":"Gomez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I, Cippitelli A, Nava F, Piomelli D, Rodriguez dF (2002) A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 22:9612\u20139617","journal-title":"J Neurosci"},{"key":"17_CR40_17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00002030-199201000-00018","volume":"6","author":"R Gorter","year":"1992","unstructured":"Gorter R, Seefried M, Volberding P (1992) Dronabinol effects on weight in patients with HIV infection. AIDS 6:127","journal-title":"AIDS"},{"key":"17_CR41_17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00427475","volume":"49","author":"I Greenberg","year":"1976","unstructured":"Greenberg I, Kuehnle J, Mendelson JH, Bernstein JG (1976) Effects of marihuana use on body weight and caloric intake in humans. Psychopharmacology (Berl) 49:79\u201384","journal-title":"Psychopharmacology (Berl)"},{"key":"17_CR42_17","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S0006-8993(02)03245-6","volume":"952","author":"JA Harrold","year":"2002","unstructured":"Harrold JA, Elliott JC, King PJ, Widdowson PS, Williams G (2002) Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food? Brain Res 952:232\u2013238","journal-title":"Brain Res"},{"key":"17_CR43_17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/cpt197112144","volume":"12","author":"LE Hollister","year":"1971","unstructured":"Hollister LE (1971) Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamine. Clin Pharmacol Ther 12:44\u201349","journal-title":"Clin Pharmacol Ther"},{"key":"17_CR44_17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/3-540-26573-2_2","volume":"168","author":"AC Howlett","year":"2005","unstructured":"Howlett AC (2005) Cannabinoid receptor signaling. Handb Exp Pharmacol 168:53\u201379","journal-title":"Handb Exp Pharmacol"},{"key":"17_CR45_17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1124\/pr.54.2.161","volume":"54","author":"AC Howlett","year":"2002","unstructured":"Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161\u2013202","journal-title":"Pharmacol Rev"},{"key":"17_CR46_17","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1476-5381.2009.00183.x","volume":"158","author":"AA Izzo","year":"2009","unstructured":"Izzo AA, Piscitelli F, Capasso R, Aviello G, Romano B, Borrelli F, Petrosino S, Di Marzo V (2009) Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. Br J Pharmacol 158:451\u2013461","journal-title":"Br J Pharmacol"},{"key":"17_CR47_17","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/sj.bjp.0704379","volume":"134","author":"N Jamshidi","year":"2001","unstructured":"Jamshidi N, Taylor DA (2001) Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br J Pharmacol 134:1151\u20131154","journal-title":"Br J Pharmacol"},{"key":"17_CR48_17","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1096\/fj.04-3177fje","volume":"19","author":"O Jbilo","year":"2005","unstructured":"Jbilo O, Ravinet Trillou C, Arnone M, Buisson I, Bribes E, Peleraux A, Penarier G, Soubrie P, Le Fur G, Galiegue S, Casellas P (2005) The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. FASEB J 19:1567\u20131569","journal-title":"FASEB J"},{"key":"17_CR49_17","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.neuron.2005.10.021","volume":"48","author":"YH Jo","year":"2005","unstructured":"Jo YH, Chen YJ, Chua SC Jr, Talmage DA, Role LW (2005) Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 48:1055\u20131066","journal-title":"Neuron"},{"key":"17_CR50_17","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/nrd2775","volume":"7","author":"D Jones","year":"2008","unstructured":"Jones D (2008) End of the line for cannabinoid receptor 1 as an anti-obesity target? Nat Rev Drug Discov 7:961\u2013962","journal-title":"Nat Rev Drug Discov"},{"key":"17_CR51_17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/HJH.0b013e3283427c8b","volume":"29","author":"J Jordan","year":"2011","unstructured":"Jordan J, Schlaich M, Redon J, Narkiewicz K, Luft FC, Grassi G, Dixon J, Lambert G, Engeli S (2011) European Society of Hypertension Working Group on Obesity: obesity drugs and cardiovascular outcomes. J Hypertens 29:189\u2013193","journal-title":"J Hypertens"},{"key":"17_CR52_17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/j.1463-1326.2009.01188.x","volume":"12","author":"MS Kipnes","year":"2010","unstructured":"Kipnes MS, Hollander P, Fujioka K, Gantz I, Seck T, Erondu N, Shentu Y, Lu K, Suryawanshi S, Chou M, Johnson-Levonas AO, Heymsfield SB, Shapiro D, Kaufman KD, Amatruda JM (2010) A one-year study to assess the safety and efficacy of the CB1R inverse agonist taranabant in overweight and obese patients with type 2 diabetes. Diabetes Obes Metab 12:517\u2013531","journal-title":"Diabetes Obes Metab"},{"key":"17_CR53_17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1079\/095442201108729141","volume":"14","author":"TC Kirkham","year":"2001","unstructured":"Kirkham TC, Williams CM (2001) Endogenous cannabinoids and appetite. Nutr Res Rev 14:65\u201386","journal-title":"Nutr Res Rev"},{"key":"17_CR54_17","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/sj.bjp.0704767","volume":"136","author":"TC Kirkham","year":"2002","unstructured":"Kirkham TC, Williams CM, Fezza F, Di Marzo V (2002) Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 136:550\u2013557","journal-title":"Br J Pharmacol"},{"key":"17_CR55_17","doi-asserted-by":"publisher","first-page":"25196","DOI":"10.1074\/jbc.C500175200","volume":"280","author":"B Kola","year":"2005","unstructured":"Kola B, Hubina E, Tucci SA, Kirkham TC, Garcia EA, Mitchell SE, Williams LM, Hawley SA, Hardie DG, Grossman AB, Korbonits M (2005) Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem 280:25196\u201325201","journal-title":"J Biol Chem"},{"key":"17_CR56_17","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/ijo.2008.3","volume":"32","author":"I Kunz","year":"2008","unstructured":"Kunz I, Meier MK, Bourson A, Fisseha M, Schilling W (2008) Effects of rimonabant, a cannabinoid CB1 receptor ligand, on energy expenditure in lean rats. Int J Obes (Lond) 32:863\u2013870","journal-title":"Int J Obes (Lond)"},{"key":"17_CR57_17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1126\/science.283.5400.401","volume":"283","author":"C Ledent","year":"1999","unstructured":"Ledent C, Valverde O, Cossu G, Petitet F, Aubert JF, Beslot F, Bohme GA, Imperato A, Pedrazzini T, Roques BP, Vassart G, Fratta W, Parmentier M (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283:401\u2013404","journal-title":"Science"},{"key":"17_CR58_17","doi-asserted-by":"publisher","first-page":"7584","DOI":"10.1021\/jm060996+","volume":"49","author":"LS Lin","year":"2006","unstructured":"Lin LS, Lanza TJ Jr, Jewell JP, Liu P, Shah SK, Qi H, Tong X, Wang J, Xu SS, Fong TM, Shen CP, Lao J, Xiao JC, Shearman LP, Stribling DS, Rosko K, Strack A, Marsh DJ, Feng Y, Kumar S, Samuel K, Yin W, Van der Ploeg LH, Goulet MT, Hagmann WK (2006) Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. J Med Chem 49:7584\u20137587","journal-title":"J Med Chem"},{"key":"17_CR59_17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/sj.ijo.0802847","volume":"29","author":"YL Liu","year":"2005","unstructured":"Liu YL, Connoley IP, Wilson CA, Stock MJ (2005) Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)\/Lep(ob) mice. Int J Obes (Lond) 29:183\u2013187","journal-title":"Int J Obes (Lond)"},{"key":"17_CR60_17","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.bmcl.2008.12.059","volume":"19","author":"J LoVerme","year":"2009","unstructured":"LoVerme J, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Stella N, Xu C, Tarzia G, Piomelli D (2009) Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorg Med Chem Lett 19:639\u2013643","journal-title":"Bioorg Med Chem Lett"},{"key":"17_CR61_17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/molehr\/gah130","volume":"11","author":"M Maccarrone","year":"2005","unstructured":"Maccarrone M, Fride E, Bisogno T, Bari M, Cascio MG, Battista N, Finazzi AA, Suris R, Mechoulam R, Di Marzo V (2005) Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob\/ob) mice and implications for fertility. Mol Hum Reprod 11:21\u201328","journal-title":"Mol Hum Reprod"},{"key":"17_CR62_17","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nature00839","volume":"418","author":"G Marsicano","year":"2002","unstructured":"Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgansberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530\u2013534","journal-title":"Nature"},{"key":"17_CR63_17","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1210\/jc.2005-2679","volume":"91","author":"I Matias","year":"2006","unstructured":"Matias I, Gonthier MP, Orlando P, Martiadis V, De Petrocellis L, Cervino C, Petrosino S, Hoareau L, Festy F, Pasquali R, Roche R, Maj M, Pagotto U, Monteleone P, Di Marzo V (2006) Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. J Clin Endocrinol Metab 91:3171\u20133180","journal-title":"J Clin Endocrinol Metab"},{"key":"17_CR64_17","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.neuropharm.2007.06.011","volume":"54","author":"I Matias","year":"2008","unstructured":"Matias I, Vergoni AV, Petrosino S, Ottani A, Pocai A, Bertolini A, Di Marzo V (2008) Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins. Neuropharmacology 54:206\u2013212","journal-title":"Neuropharmacology"},{"key":"17_CR65_17","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/346561a0","volume":"346","author":"LA Matsuda","year":"1990","unstructured":"Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561\u2013564","journal-title":"Nature"},{"key":"17_CR66_17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","volume":"50","author":"R Mechoulam","year":"1995","unstructured":"Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50:83\u201390","journal-title":"Biochem Pharmacol"},{"key":"17_CR67_17","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.beem.2008.09.003","volume":"23","author":"FA Moreira","year":"2009","unstructured":"Moreira FA, Grieb M, Lutz B (2009) Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression. Best Pract Res Clin Endocrinol Metab 23:133\u2013144","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"17_CR68_17","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/365061a0","volume":"365","author":"S Munro","year":"1993","unstructured":"Munro S, Thomas KL, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61\u201365","journal-title":"Nature"},{"key":"17_CR69_17","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.2337\/db08-0161","volume":"57","author":"R Nogueiras","year":"2008","unstructured":"Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tsch\u00f6p J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner-Jeanrenaud F, Tsch\u00f6p MH (2008) Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes 57:2977\u20132991","journal-title":"Diabetes"},{"key":"17_CR70_17","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.2337\/db10-0962","volume":"60","author":"JD O\u2019Hare","year":"2011","unstructured":"O\u2019Hare JD, Zielinski E, Cheng B, Scherer T, Buettner C (2011) Central endocannabinoid signaling regulates hepatic glucose production and systemic lipolysis. Diabetes 60:1055\u20131062","journal-title":"Diabetes"},{"key":"17_CR71_17","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1159\/000087925","volume":"81","author":"D Osei-Hyiaman","year":"2005","unstructured":"Osei-Hyiaman D, Depetrillo M, Harvey-White J, Bannon AW, Cravatt BF, Kuhar MJ, Mackie K, Palkovits M, Kunos G (2005a) Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide. Neuroendocrinology 81:273\u2013282","journal-title":"Neuroendocrinology"},{"key":"17_CR72_17","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI200523057","volume":"115","author":"D Osei-Hyiaman","year":"2005","unstructured":"Osei-Hyiaman D, Depetrillo M, Pacher P, Liu J, Radaeva S, Batkai S, Harvey-White J, Mackie K, Offertaler L, Wang L, Kunos G (2005b) Endocannabinoid activation at hepatic CB(1) receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest 115:1298\u20131305","journal-title":"J Clin Invest"},{"key":"17_CR73_17","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1172\/JCI34827","volume":"118","author":"D Osei-Hyiaman","year":"2008","unstructured":"Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong WI, Batkai S, Marsicano G, Lutz B, Buettner C, Kunos G (2008) Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest 118:3160\u20133169","journal-title":"J Clin Invest"},{"key":"17_CR74_17","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1124\/pr.58.3.2","volume":"58","author":"P Pacher","year":"2006","unstructured":"Pacher P, Batkai S, Kunos G (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58:389\u2013462","journal-title":"Pharmacol Rev"},{"key":"17_CR75_17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1210\/er.2005-0009","volume":"27","author":"U Pagotto","year":"2006","unstructured":"Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R (2006) The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 27:73\u2013100","journal-title":"Endocr Rev"},{"key":"17_CR76_17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/3-540-26573-2_1","volume":"168","author":"RG Pertwee","year":"2005","unstructured":"Pertwee RG (2005) Pharmacological actions of cannabinoids. Handb Exp Pharmacol 168:1\u201351","journal-title":"Handb Exp Pharmacol"},{"key":"17_CR77_17","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1124\/pr.110.003004","volume":"62","author":"RG Pertwee","year":"2010","unstructured":"Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, Mechoulam R, Ross RA (2010) International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2. Pharmacol Rev 62:588\u2013631","journal-title":"Pharmacol Rev"},{"key":"17_CR78_17","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1055\/s-2006-925401","volume":"38","author":"N Perwitz","year":"2006","unstructured":"Perwitz N, Fasshauer M, Klein J (2006) Cannabinoid receptor signaling directly inhibits thermogenesis and alters expression of adiponectin and visfatin. Horm Metab Res 38:356\u2013358","journal-title":"Horm Metab Res"},{"key":"17_CR79_17","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/nrn1247","volume":"4","author":"D Piomelli","year":"2003","unstructured":"Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873\u2013884","journal-title":"Nat Rev Neurosci"},{"key":"17_CR80_17","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1001\/jama.295.7.761","volume":"295","author":"FX Pi-Sunyer","year":"2006","unstructured":"Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J (2006) Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 295:761\u2013775","journal-title":"JAMA"},{"key":"17_CR81_17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0091-3057(91)90385-F","volume":"40","author":"TF Plasse","year":"1991","unstructured":"Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, Wadleigh RG (1991) Recent clinical experience with dronabinol. Pharmacol Biochem Behav 40:695\u2013700","journal-title":"Pharmacol Biochem Behav"},{"key":"17_CR82_17","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/ijo.2010.38","volume":"34","author":"J Proietto","year":"2010","unstructured":"Proietto J, Rissanen A, Harp JB, Erondu N, Yu Q, Suryawanshi S, Jones ME, Johnson-Levonas AO, Heymsfield SB, Kaufman KD, Amatruda JM (2010) A clinical trial assessing the safety and efficacy of the CB1R inverse agonist taranabant in obese and overweight patients: low-dose study. Int J Obes (Lond) 34:1243\u20131254","journal-title":"Int J Obes (Lond)"},{"key":"17_CR83_17","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cmet.2010.02.015","volume":"11","author":"C Quarta","year":"2010","unstructured":"Quarta C, Bellocchio L, Mancini G, Mazza R, Cervino C, Braulke LJ, Fekete C, Latorre R, Nanni C, Bucci M, Clemens LE, Heldmaier G, Watanabe M, Leste-Lassere T, Maitre M, Tedesco L, Fanelli F, Reuss S, Klaus S, Srivastava RK, Monory K, Valerio A, Grandis A, De Giorgio R, Pasquali R, Nisoli E, Cota D, Lutz B, Marsicano G, Pagotto U (2010) CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metab 11:273\u2013285","journal-title":"Cell Metab"},{"key":"17_CR84_17","doi-asserted-by":"crossref","first-page":"R345","DOI":"10.1152\/ajpregu.00545.2002","volume":"284","author":"C Ravinet Trillou","year":"2003","unstructured":"Ravinet Trillou C, Arnone M, Delgorge C, Gonalons N, Keane P, Maffrand JP, Soubrie P (2003) Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am J Physiol Regul Integr Comp Physiol 284:R345\u2013R353","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"17_CR85_17","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/sj.ijo.0802583","volume":"28","author":"C Ravinet Trillou","year":"2004","unstructured":"Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrie P (2004) CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes Relat Metab Disord 28:640\u2013648","journal-title":"Int J Obes Relat Metab Disord"},{"key":"17_CR86_17","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/0014-5793(94)00773-X","volume":"350","author":"M Rinaldi-Carmona","year":"1994","unstructured":"Rinaldi-Carmona M, Barth F, Heaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Neliat G, Caput D (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240\u2013244","journal-title":"FEBS Lett"},{"key":"17_CR87_17","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/3-540-26573-2_25","volume":"168","author":"P Robson","year":"2005","unstructured":"Robson P (2005) Human studies of cannabinoids and medicinal cannabis. Handb Exp Pharmacol 168:719\u2013756","journal-title":"Handb Exp Pharmacol"},{"key":"17_CR88_17","doi-asserted-by":"publisher","first-page":"G507","DOI":"10.1152\/ajpgi.00173.2010","volume":"299","author":"JC Russell","year":"2010","unstructured":"Russell JC, Kelly SE, Diane A, Wang Y, Mangat R, Novak S, Vine DF, Proctor SD (2010) Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome. Am J Physiol Gastrointest Liver Physiol 299:G507\u2013G516","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"17_CR89_17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1056\/NEJM198001173020302","volume":"302","author":"SE Sallan","year":"1980","unstructured":"Sallan SE, Cronin C, Zelen M, Zinberg NE (1980) Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. N Engl J Med 302:135\u2013138","journal-title":"N Engl J Med"},{"key":"17_CR90_17","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1016\/S0140-6736(06)69571-8","volume":"368","author":"AJ Scheen","year":"2006","unstructured":"Scheen AJ, Finer N, Hollander P, Jensen MD, van Gaal LF (2006) Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 368:1660\u20131672","journal-title":"Lancet"},{"key":"17_CR91_17","first-page":"269","volume":"73","author":"JF Siler","year":"1933","unstructured":"Siler JF, Sheep WL, Bates LB, Clark GF, Cook GW, Smith WH (1933) Marihuana smoking in Panama. Mil Surg 73:269\u2013280","journal-title":"Mil Surg"},{"key":"17_CR92_17","first-page":"179","volume":"9","author":"J Simiand","year":"1998","unstructured":"Simiand J, Keane M, Keane PE, Soubrie P (1998) SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Behav Pharmacol 9:179\u2013181","journal-title":"Behav Pharmacol"},{"key":"17_CR93_17","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/sj.bjp.0707313","volume":"151","author":"E Soria-Gomez","year":"2007","unstructured":"Soria-Gomez E, Matias I, Rueda-Orozco PE, Cisneros M, Petrosino S, Navarro L, Di Marzo V, Prospero-Garcia O (2007) Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. Br J Pharmacol 151:1109\u20131116","journal-title":"Br J Pharmacol"},{"issue":"Suppl 1","key":"17_CR94_17","first-page":"S25","volume":"21","author":"MJ Stock","year":"1997","unstructured":"Stock MJ (1997) Sibutramine: a review of the pharmacology of a novel anti- obesity agent. Int J Obes Relat Metab Disord 21(Suppl 1):S25\u2013S29","journal-title":"Int J Obes Relat Metab Disord"},{"key":"17_CR95_17","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.coph.2007.08.008","volume":"7","author":"MA Storr","year":"2007","unstructured":"Storr MA, Sharkey KA (2007) The endocannabinoid system and gut-brain signalling. Curr Opin Pharmacol 7:575\u2013582","journal-title":"Curr Opin Pharmacol"},{"key":"17_CR96_17","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1172\/JCI42551","volume":"120","author":"J Tam","year":"2010","unstructured":"Tam J, Vemuri VK, Liu J, Batkai S, Mukhopadhyay B, Godlewski G, Osei-Hyiaman D, Ohnuma S, Ambudkar SV, Pickel J, Makriyannis A, Kunos G (2010) Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest 120:2953\u20132966","journal-title":"J Clin Invest"},{"key":"17_CR97_17","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/226701a0","volume":"226","author":"CT Tart","year":"1970","unstructured":"Tart CT (1970) Marijuana intoxication common experiences. Nature 226:701\u2013704","journal-title":"Nature"},{"key":"17_CR98_17","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.2337\/db07-1623","volume":"57","author":"L Tedesco","year":"2008","unstructured":"Tedesco L, Valerio A, Cervino C, Cardile A, Pagano C, Vettor R, Pasquali R, Carruba MO, Marsicano G, Lutz B, Pagotto U, Nisoli E (2008) Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes. Diabetes 57:2028\u20132036","journal-title":"Diabetes"},{"key":"17_CR99_17","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.2337\/db09-1881","volume":"59","author":"L Tedesco","year":"2010","unstructured":"Tedesco L, Valerio A, Dossena M, Cardile A, Ragni M, Pagano C, Pagotto U, Carruba MO, Vettor R, Nisoli E (2010) Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. Diabetes 59:2826\u20132836","journal-title":"Diabetes"},{"key":"17_CR100_17","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1517\/13543770903436505","volume":"19","author":"GA Thakur","year":"2009","unstructured":"Thakur GA, Tichkule R, Bajaj S, Makriyannis A (2009) Latest advances in cannabinoid receptor agonists. Expert Opin Ther Pat 19:1647\u20131673","journal-title":"Expert Opin Ther Pat"},{"key":"17_CR101_17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.pbb.2006.06.001","volume":"84","author":"ZD Thornton-Jones","year":"2006","unstructured":"Thornton-Jones ZD, Kennett GA, Benwell KR, Revell DF, Misra A, Sellwood DM, Vickers SP, Clifton PG (2006) The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake. Pharmacol Biochem Behav 84:353\u2013359","journal-title":"Pharmacol Biochem Behav"},{"key":"17_CR102_17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0140-6736(10)60935-X","volume":"376","author":"EJ Topol","year":"2010","unstructured":"Topol EJ, Bousser MG, Fox KA, Creager MA, Despr\u00e9s JP, Easton JD, Hamm CW, Montalescot G, Steg PG, Pearson TA, Cohen E, Gaudin C, Job B, Murphy JH, Bhatt DL (2010) Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet 376:517\u2013523","journal-title":"Lancet"},{"key":"17_CR103_17","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/sj.bjp.0705968","volume":"143","author":"SA Tucci","year":"2004","unstructured":"Tucci SA, Rogers EK, Korbonits M, Kirkham TC (2004) The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin. Br J Pharmacol 143:520\u2013523","journal-title":"Br J Pharmacol"},{"key":"17_CR104_17","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/S0140-6736(05)66374-X","volume":"365","author":"LF Gaal van","year":"2005","unstructured":"van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, R\u00f6ossner S (2005) Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365:1389\u20131397","journal-title":"Lancet"},{"key":"17_CR105_17","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/(SICI)1099-1166(199709)12:9<913::AID-GPS663>3.0.CO;2-D","volume":"12","author":"L Volicer","year":"1997","unstructured":"Volicer L, Stelly M, Morris J, McLaughlin J, Volicer BJ (1997) Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer\u2019s disease. Int J Geriatr Psychiatry 12:913\u2013919","journal-title":"Int J Geriatr Psychiatry"},{"key":"17_CR106_17","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1038\/oby.2010.67","volume":"18","author":"TA Wadden","year":"2010","unstructured":"Wadden TA, Fujioka K, Toubro S, Gantz I, Erondu NE, Chen M, Suryawanshi S, Carofano W, Johnson-Levonas AO, Shapiro DR, Kaufman KD, Heymsfield SB, Amatruda JM (2010) A randomized trial of lifestyle modification and taranabant for maintaining weight loss achieved with a low-calorie diet. Obesity (Silver Spring) 18:2301\u20132310","journal-title":"Obesity (Silver Spring)"},{"key":"17_CR107_17","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/BF03347017","volume":"26","author":"S Wallerius","year":"2003","unstructured":"Wallerius S, Rosmond R, Ljung T, Holm G, Bj\u00f6rntorp P (2003) Rise in morning saliva cortisol is associated with abdominal obesity in men: a preliminary report. J Endocrinol Invest 26:616\u2013619","journal-title":"J Endocrinol Invest"},{"key":"17_CR108_17","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1360-0443.2009.02776.x","volume":"105","author":"MA Ware","year":"2010","unstructured":"Ware MA, St Arnaud-Trempe E (2010) The abuse potential of the synthetic cannabinoid nabilone. Addiction 105:494\u2013503","journal-title":"Addiction"},{"key":"17_CR109_17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0952-3278(03)00056-5","volume":"69","author":"S Watanabe","year":"2003","unstructured":"Watanabe S, Doshi M, Hamazaki T (2003) n-3 Polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in mice. Prostaglandins Leukot Essent Fatty Acids 69:51\u201359","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"17_CR110_17","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s002130050953","volume":"143","author":"CM Williams","year":"1999","unstructured":"Williams CM, Kirkham TC (1999) Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. Psychopharmacology (Berl) 143:315\u2013317","journal-title":"Psychopharmacology (Berl)"},{"key":"17_CR111_17","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0031-9384(02)00725-4","volume":"76","author":"CM Williams","year":"2002","unstructured":"Williams CM, Kirkham TC (2002) Observational analysis of feeding induced by Delta9-THC and anandamide. Physiol Behav 76:241\u2013250","journal-title":"Physiol Behav"},{"key":"17_CR112_17","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/35069076","volume":"410","author":"RI Wilson","year":"2001","unstructured":"Wilson RI, Nicoll RA (2001) Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature 410:588\u2013592","journal-title":"Nature"},{"key":"17_CR113_17","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/cne.21383","volume":"503","author":"G Wittmann","year":"2007","unstructured":"Wittmann G, Deli L, Kallo I, Hrabovszky E, Watanabe M, Liposits Z, Fekete C (2007) Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus. J Comp Neurol 503:270\u2013279","journal-title":"J Comp Neurol"},{"key":"17_CR114_17","doi-asserted-by":"publisher","first-page":"5780","DOI":"10.1073\/pnas.96.10.5780","volume":"96","author":"A Zimmer","year":"1999","unstructured":"Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA 96:5780\u20135785","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Handbook of Experimental Pharmacology","Appetite Control"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-24716-3_17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T21:40:58Z","timestamp":1742334058000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-24716-3_17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,10]]},"ISBN":["9783642247156","9783642247163"],"references-count":114,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-24716-3_17","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,10]]}}}