{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T01:38:40Z","timestamp":1743039520374,"version":"3.40.3"},"publisher-location":"Berlin, Heidelberg","reference-count":25,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783642248542"},{"type":"electronic","value":"9783642248559"}],"license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"DOI":"10.1007\/978-3-642-24855-9_19","type":"book-chapter","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T03:05:26Z","timestamp":1319771126000},"page":"214-224","source":"Crossref","is-referenced-by-count":0,"title":["Flux Measurement Selection in Metabolic Networks"],"prefix":"10.1007","author":[{"given":"Wout","family":"Megchelenbrink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn","family":"Huynen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Marchiori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"6977","key":"19_CR1","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/nature02289","volume":"427","author":"E. Almaas","year":"2004","unstructured":"Almaas, E., Kov\u00e1cs, B., Vicsek, T., Oltvai, Z.N., Barab\u00e1si, A.-L.: Global organization of metabolic fluxes in the bacterium escherichia coli. Nature\u00a0427(6977), 839\u2013843 (2004)","journal-title":"Nature"},{"key":"19_CR2","unstructured":"Beeler, B., Enge, A., Fukuda, K., Lthi, H.-J.: Exact volume computation for polytopes: a practical study. In: 12th European Workshop on Computational Geometry, Muenster, Germany (1996)"},{"issue":"1","key":"19_CR3","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/1471-2105-9-240","volume":"9","author":"A. Braunstein","year":"2008","unstructured":"Braunstein, A., Mulet, R., Pagnani, A.: Estimating the size of the solution space of metabolic networks. BMC Bioinformatics\u00a09(1), 240 (2008)","journal-title":"BMC Bioinformatics"},{"issue":"2","key":"19_CR4","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1101\/gr.1926504","volume":"14","author":"A.P. Burgard","year":"2004","unstructured":"Burgard, A.P., Nikolaev, E.V., Schilling, C.H., Maranas, C.D.: Flux coupling analysis of genome-scale metabolic network reconstructions. Genome Research\u00a014(2), 301\u2013312 (2004)","journal-title":"Genome Research"},{"issue":"3","key":"19_CR5","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1214\/ss\/1177009939","volume":"10","author":"K. Chaloner","year":"1995","unstructured":"Chaloner, K., Verdinelli, I.: Bayesian experimental design: A review. Statistical Science\u00a010(3), 273\u2013304 (1995)","journal-title":"Statistical Science"},{"issue":"1","key":"19_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/1471-2105-12-236","volume":"12","author":"L. David","year":"2011","unstructured":"David, L., Marashi, S.-A., Larhlimi, A., Mieth, B., Bockmayr, A.: FFCA: a feasibility-based method for flux coupling analysis of metabolic networks. BMC Bioinformatics\u00a012(1), 236 (2011)","journal-title":"BMC Bioinformatics"},{"key":"19_CR7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1186\/1471-2105-11-489","volume":"11","author":"S. Gudmundsson","year":"2010","unstructured":"Gudmundsson, S., Thiele, I.: Computationally efficient flux variability analysis. BMC Bioinformatics\u00a011, 489 (2010)","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"19_CR8","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1093\/bioinformatics\/17.3.286","volume":"17","author":"N. Jamshidi","year":"2001","unstructured":"Jamshidi, N., Edwards, J.S., Fahland, T., Church, G.M., Palsson, B.O.: Dynamic simulation of the human red blood cell metabolic network. Bioinformatics\u00a017(3), 286\u2013287 (2001)","journal-title":"Bioinformatics"},{"issue":"5","key":"19_CR9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.copbio.2003.08.001","volume":"14","author":"K.J. Kauffman","year":"2003","unstructured":"Kauffman, K.J., Prakash, P., Edwards, J.S.: Advances in flux balance analysis. Current Opinion in Biotechnology\u00a014(5), 491\u2013496 (2003)","journal-title":"Current Opinion in Biotechnology"},{"issue":"1","key":"19_CR10","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1287\/opre.46.1.84","volume":"46","author":"D.E. Kaufman","year":"1998","unstructured":"Kaufman, D.E., Smith, R.L.: Direction choice for accelerated convergence in hit-and-run sampling. Operations Research\u00a046(1), 84\u201395 (1998)","journal-title":"Operations Research"},{"issue":"4","key":"19_CR11","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.ymben.2003.09.002","volume":"5","author":"R. Mahadevan","year":"2003","unstructured":"Mahadevan, R., Schilling, C.H.: The effects of alternate optimal solutions in constraint-based genome-scale metabolic models. Metabolic Engineering\u00a05(4), 264\u2013276 (2003)","journal-title":"Metabolic Engineering"},{"issue":"3","key":"19_CR12","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nbt.1614","volume":"28","author":"J.D. Orth","year":"2010","unstructured":"Orth, J.D., Thiele, I., Palsson, B.O.: What is flux balance analysis? Nature Biotechnology\u00a028(3), 245\u2013248 (2010)","journal-title":"Nature Biotechnology"},{"key":"19_CR13","doi-asserted-by":"crossref","unstructured":"Palsson, B.O.: Systems Biology: Properties of Reconstructed Networks, 1st edn. Cambridge University Press (2006)","DOI":"10.1017\/CBO9780511790515"},{"issue":"11","key":"19_CR14","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nrmicro1023","volume":"2","author":"N.D. Price","year":"2004","unstructured":"Price, N.D., Reed, J.L., Palsson, B.O.: Genome-scale models of microbial cells: evaluating the consequences of constraints. Nature Reviews Microbiology\u00a02(11), 886\u2013897 (2004)","journal-title":"Nature Reviews Microbiology"},{"issue":"4","key":"19_CR15","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1529\/biophysj.104.043000","volume":"87","author":"N.D. Price","year":"2004","unstructured":"Price, N.D., Schellenberger, J., Palsson, B.O.: Uniform sampling of Steady-State flux spaces: Means to design experiments and to interpret enzymopathies. Biophysical Journal\u00a087(4), 2172\u20132186 (2004)","journal-title":"Biophysical Journal"},{"key":"19_CR16","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/msb4100109","volume":"2","author":"U. Sauer","year":"2006","unstructured":"Sauer, U.: Metabolic networks in motion: 13C-based flux analysis. Molecular Systems Biology\u00a02, 62 (2006)","journal-title":"Molecular Systems Biology"},{"issue":"2","key":"19_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0022-5193(05)80595-8","volume":"155","author":"J.M. Savinell","year":"1992","unstructured":"Savinell, J.M., Palsson, B.O.: Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods. Journal of Theoretical Biology\u00a0155(2), 201\u2013214 (1992)","journal-title":"Journal of Theoretical Biology"},{"issue":"2","key":"19_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0022-5193(05)80596-X","volume":"155","author":"J.M. Savinell","year":"1992","unstructured":"Savinell, J.M., Palsson, B.O.: Optimal selection of metabolic fluxes for in vivo measurement. II. Application to escherichia coli and hybridoma cell metabolism. Journal of Theoretical Biology\u00a0155(2), 215\u2013242 (1992)","journal-title":"Journal of Theoretical Biology"},{"issue":"3","key":"19_CR19","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.bpj.2010.12.3707","volume":"100","author":"J. Schellenberger","year":"2011","unstructured":"Schellenberger, J., Lewis, N.E., Palsson, B.O.: Elimination of thermodynamically infeasible loops in steady-state metabolic models. Biophysical Journal\u00a0100(3), 544\u2013553 (2011)","journal-title":"Biophysical Journal"},{"issue":"9","key":"19_CR20","doi-asserted-by":"publisher","first-page":"5457","DOI":"10.1074\/jbc.R800048200","volume":"284","author":"J. Schellenberger","year":"2009","unstructured":"Schellenberger, J., Palsson, B.O.: Use of randomized sampling for analysis of metabolic networks. The Journal of Biological Chemistry\u00a0284(9), 5457\u20135461 (2009)","journal-title":"The Journal of Biological Chemistry"},{"issue":"9","key":"19_CR21","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/nprot.2011.308","volume":"6","author":"J. Schellenberger","year":"2011","unstructured":"Schellenberger, J., et al.: Quantitative prediction of cellular metabolism with constraint-basded models: the cobra toolbox v2.0. Nature Protocols\u00a06(9), 1290\u20131307 (2011)","journal-title":"Nature Protocols"},{"issue":"23","key":"19_CR22","doi-asserted-by":"publisher","first-page":"15112","DOI":"10.1073\/pnas.232349399","volume":"99","author":"D. Segr\u00e9","year":"2002","unstructured":"Segr\u00e9, D., Vitkup, D., Church, G.M.: Analysis of optimality in natural and perturbed metabolic networks. Proceedings of the National Academy of Sciences of the United States of America\u00a099(23), 15112\u201315117 (2002)","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"19_CR23","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.jtbi.2009.01.027","volume":"258","author":"K. Smallbone","year":"2009","unstructured":"Smallbone, K., Simeonidis, E.: Flux balance analysis: a geometric perspective. Journal of Theoretical Biology\u00a0258(2), 311\u2013315 (2009)","journal-title":"Journal of Theoretical Biology"},{"key":"19_CR24","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/nbt1094-994","volume":"12","author":"A. Varma","year":"1994","unstructured":"Varma, A., Palsson, B.O.: Metabolic flux balancing: Basic concepts, scientific and practical use. Nature Biotechnology\u00a012, 994 (1994)","journal-title":"Nature Biotechnology"},{"issue":"4","key":"19_CR25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jtbi.2004.02.006","volume":"228","author":"S.J. Wiback","year":"2004","unstructured":"Wiback, S.J., Famili, I., Harvey, J., Greenberg, H.J., Palsson, B.O.: Monte carlo sampling can be used to determine the size and shape of the steady-state flux space. Journal of Theoretical Biology\u00a0228(4), 437\u2013447 (2004)","journal-title":"Journal of Theoretical Biology"}],"container-title":["Lecture Notes in Computer Science","Pattern Recognition in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-24855-9_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T20:28:08Z","timestamp":1558297688000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-24855-9_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"ISBN":["9783642248542","9783642248559"],"references-count":25,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-24855-9_19","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2011]]}}}