{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T21:20:52Z","timestamp":1725657652660},"publisher-location":"Berlin, Heidelberg","reference-count":43,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783642282782"},{"type":"electronic","value":"9783642282799"}],"license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-3-642-28279-9_17","type":"book-chapter","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T01:47:18Z","timestamp":1328665638000},"page":"231-250","source":"Crossref","is-referenced-by-count":6,"title":["Conceptual Modeling of Human Genome: Integration Challenges"],"prefix":"10.1007","author":[{"given":"Oscar","family":"Pastor","sequence":"first","affiliation":[]},{"given":"Juan Carlos","family":"Casamayor","sequence":"additional","affiliation":[]},{"given":"Matilde","family":"Celma","sequence":"additional","affiliation":[]},{"given":"Laura","family":"Mota","sequence":"additional","affiliation":[]},{"given":"M. \u00c1ngeles","family":"Pastor","sequence":"additional","affiliation":[]},{"given":"Ana M.","family":"Levin","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"17_CR1","volume-title":"Conceptual Modelling of Information Systems","author":"A. Oliv\u00e9","year":"2007","unstructured":"Oliv\u00e9, A.: Conceptual Modelling of Information Systems. Springer, Heidelberg (2007)"},{"key":"17_CR2","unstructured":"Falkenberg, E., Hesse, W., Lindgreen, W., Nilsson, E., Han, J., Rolland, C., Stamper, R., Van Assche, F., Verrijn-Stuart, A., Voss, K.: A Framework of Information System Concepts. IFIP (1998)"},{"key":"17_CR3","volume-title":"Model-Driven Architecture in Practice","author":"O. Pastor","year":"2007","unstructured":"Pastor, O., Molina, J.C.: Model-Driven Architecture in Practice. Springer, Heidelberg (2007)"},{"key":"17_CR4","doi-asserted-by":"crossref","unstructured":"Thorisson, G.A., Muilu, J., Brookes, A.: Genotype-phenotype databases: challenges and solutions for the post-genomic era. Nature Reviews \u2013 Genetics\u00a010 (2009)","DOI":"10.1038\/nrg2483"},{"key":"17_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/417119a","volume":"417","author":"L. Stein","year":"2002","unstructured":"Stein, L.: Creating a bioinformatics nation. Nature\u00a0417, 119\u2013120 (2002)","journal-title":"Nature"},{"key":"17_CR6","doi-asserted-by":"crossref","unstructured":"Crowd sourcing human mutations (Editorial). Nature Genetics 43(4) (2011)","DOI":"10.1038\/ng0411-279"},{"key":"17_CR7","doi-asserted-by":"crossref","unstructured":"The Gene Ontology Consortium.: Gene Ontology: tool for the unification of biology. Nat. Genet.\u00a025, 25\u201329 (2000)","DOI":"10.1038\/75556"},{"key":"17_CR8","unstructured":"http:\/\/www.geneontology.org\/\n                  \n                  \n                 (accessed December 05, 2011)"},{"key":"17_CR9","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/gene\n                  \n                  \n                 (accessed December 05, 2011)"},{"issue":"1","key":"17_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1093\/nar\/30.1.38","volume":"30","author":"T. Hubbard","year":"2002","unstructured":"Hubbard, T., et al.: The Ensembl genome database project. Nucleic Acids Research\u00a030(1), 38\u201341 (2002)","journal-title":"Nucleic Acids Research"},{"key":"17_CR11","unstructured":"http:\/\/www.ensembl.org\n                  \n                  \n                 (accessed December 05, 2011)"},{"key":"17_CR12","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/genbank\/\n                  \n                  \n                 (accessed December 05, 2011)"},{"key":"17_CR13","unstructured":"http:\/\/www.hgmd.org\/\n                  \n                  \n                 (accessed December 05, 2011)"},{"issue":"5","key":"17_CR14","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s004390050272","volume":"98","author":"D.N. Cooper","year":"1996","unstructured":"Cooper, D.N., Krawczak, M.: Human gene mutation database. Hum. Genet.\u00a098(5), 629 (1996)","journal-title":"Hum. Genet."},{"issue":"1","key":"17_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<57::AID-HUMU12>3.0.CO;2-G","volume":"15","author":"A. Hamosh","year":"2000","unstructured":"Hamosh, A., Scott, A.F., Amberger, J., Valle, D., McKusick, V.A.: Online Mendelian Inheritance in Man (OMIM). Hum. Mutat.\u00a015(1), 57\u201361 (2000)","journal-title":"Hum. Mutat."},{"key":"17_CR16","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/omim\n                  \n                  \n                 (accessed December 05, 2011)"},{"key":"17_CR17","unstructured":"http:\/\/www.genome.jp\/kegg\/\n                  \n                  \n                 (accessed December 05, 2011)"},{"issue":"1","key":"17_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","volume":"27","author":"H. Ogata","year":"1999","unstructured":"Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., Kanehisa, M.: KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res.\u00a027(1), 29\u201334 (1999)","journal-title":"Nucleic Acids Res."},{"key":"17_CR19","doi-asserted-by":"crossref","unstructured":"Apweiler, R., et al.: UniProt: the Universal Protein knowledgebase. Nucleic Acids Res.\u00a032 (Database issue): D115-9 (2004)","DOI":"10.1093\/nar\/gkh131"},{"key":"17_CR20","unstructured":"http:\/\/www.uniprot.org\/\n                  \n                  \n                 (accessed December 05, 2011)"},{"issue":"1","key":"17_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/nar\/29.1.37","volume":"29","author":"R. Apweiler","year":"2001","unstructured":"Apweiler, R., et al.: The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Res.\u00a029(1), 37\u201340 (2001)","journal-title":"Nucleic Acids Res."},{"key":"17_CR22","unstructured":"http:\/\/www.ebi.ac.uk\/interpro\/\n                  \n                  \n                 (accessed December 05, 2011)"},{"key":"17_CR23","doi-asserted-by":"crossref","unstructured":"Croft, D., et al.: Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res.\u00a0(Database issue): D691-7 (2011)","DOI":"10.1093\/nar\/gkq1018"},{"key":"17_CR24","unstructured":"http:\/\/www.reactome.org\/ReactomeGWT\/entrypoint.html\n                  \n                  \n                 (accessed December 05, 2011)"},{"key":"17_CR25","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-540-87877-3_1","volume-title":"Conceptual Modeling - ER 2008","author":"O. Pastor","year":"2008","unstructured":"Pastor, O.: Conceptual Modeling Meets the Human Genome. In: Li, Q., Spaccapietra, S., Yu, E., Oliv\u00e9, A. (eds.) ER 2008. LNCS, vol.\u00a05231, pp. 1\u201311. Springer, Heidelberg (2008)"},{"issue":"6","key":"17_CR26","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1093\/bioinformatics\/16.6.548","volume":"16","author":"W.N. Paton","year":"2000","unstructured":"Paton, W.N., Khan, S., Hayes, A., Moussouni, F., Brass, A., Eilbeck, K., Globe, C., Hubbard, S., Oliver, S.: Conceptual modeling of genomic information. Bioinformatics\u00a016(6), 548\u2013557 (2000)","journal-title":"Bioinformatics"},{"key":"17_CR27","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/978-3-540-30464-7_52","volume-title":"Conceptual Modeling \u2013 ER 2004","author":"S. Ram","year":"2004","unstructured":"Ram, S., Wei, W.: Modeling the Semantics of 3D Protein Structures. In: Atzeni, P., Chu, W., Lu, H., Zhou, S., Ling, T.-W. (eds.) ER 2004. LNCS, vol.\u00a03288, pp. 696\u2013708. Springer, Heidelberg (2004)"},{"key":"17_CR28","first-page":"1","volume":"7, 532","author":"K. Garwood","year":"2006","unstructured":"Garwood, K., Garwood, C., Hedeler, C., Griffiths, T., Swainston, N., Oliver, S., Paton, W.: Model-driven user interface for bioinformatics data resources: regenerating the wheel as an alternative to reinventing it. Bioinformatics\u00a07, 532, 1\u201314 (2006)","journal-title":"Bioinformatics"},{"issue":"2","key":"17_CR29","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bib\/3.2.166","volume":"3","author":"E. Bornberg-Bauer","year":"2002","unstructured":"Bornberg-Bauer, E., Paton, N.: Conceptual data modelling for bioinformatics. Briefings in Bioinformatics\u00a03(2), 166\u2013180 (2002)","journal-title":"Briefings in Bioinformatics"},{"key":"17_CR30","unstructured":"e-fungi Project, \n                  \n                    http:\/\/www.cs.man.ac.uk\/cornell\/eFungi\/index.html"},{"key":"17_CR31","first-page":"1","volume":"8, 426","author":"C. Hedeler","year":"2007","unstructured":"Hedeler, C., Wong, H.M., Cornell, M.J., Alam, I., Soanes, D., Rattray, M., Hubbrad, S.J., Talbot, N.J., Oliver, S.G., Paton, N.: e-Fungi: a data resource for comparative analysis of fungal genomes. BMC Genomics\u00a08, 426, 1\u201315 (2007)","journal-title":"BMC Genomics"},{"key":"17_CR32","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/978-3-642-17505-3_14","volume-title":"The Evolution of Conceptual Modeling","author":"O. Pastor","year":"2011","unstructured":"Pastor, O., Levin, A., Celma, M., Casamayor, J., Virrueta, A., Eraso, L.: Model-Based Engineering Applied to the Interpretation of the Human Genome. In: Kaschek, R., Delcambre, L. (eds.) The Evolution of Conceptual Modeling. LNCS, vol.\u00a06520, pp. 306\u2013330. Springer, Heidelberg (2011)"},{"key":"17_CR33","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/978-3-642-15865-0_16","volume-title":"Handbook of Conceptual Modeling: Theory, Practice and Research Challenges","author":"O. Pastor","year":"2011","unstructured":"Pastor, O., van der Kroon, M., Levin, A., Casamayor, J.C., Celma, M.: A Conceptual Modeling Approach to Improve Human Genome Understanding. In: Embley, D., Thalheim, B. (eds.) Handbook of Conceptual Modeling: Theory, Practice and Research Challenges, pp. 517\u2013541. Springer, Heidelberg (2011)"},{"key":"17_CR34","doi-asserted-by":"crossref","unstructured":"International Human Genome Sequencing Consortium: Initial sequencing and analysis of the human genome. Nature\u00a0409(6822), 860\u2013921 (2001)","DOI":"10.1038\/35057062"},{"key":"17_CR35","unstructured":"Gene Nomenclature Committee, \n                  \n                    http:\/\/www.genenames.org"},{"key":"17_CR36","unstructured":"National Center for Biotechnology Information, \n                  \n                    http:\/\/www.ncbi.nlm.nih.gov"},{"key":"17_CR37","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1101\/gr.6339607","volume":"17","author":"M.B. Gerstein","year":"2007","unstructured":"Gerstein, M.B., Bruce, C., Rozowsky, J., Zheng, D., Du, J., Korbel, J., Emanuelsson, O., Zhang, Z., Weissman, S., Snyder, M.: What is a gene, post-ENCODE? History and updated definition. Genome Res.\u00a017, 669\u2013681 (2007)","journal-title":"Genome Res."},{"issue":"23","key":"17_CR38","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/j.cub.2007.10.066","volume":"17","author":"H.G. Blitzblau","year":"2007","unstructured":"Blitzblau, H.G., Bell, G.W., Rodriguez, J., Bell, S.P., Hochwagen, A.: Mapping of Meiotic Single-Stranded DNA Reveals Double-Strand-Break Hotspots near Centromeres and Telomeres. Current Biology\u00a017(23), 2003\u20132012 (2007)","journal-title":"Current Biology"},{"key":"17_CR39","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nrg2712","volume":"11","author":"K. Paigen","year":"2010","unstructured":"Paigen, K., Petkov, P.: Mammalian recombination hot spots: properties, control and evolution. Nature Reviews Genetics\u00a011, 221\u2013233 (2010)","journal-title":"Nature Reviews Genetics"},{"issue":"1","key":"17_CR40","first-page":"17","volume":"51","author":"G.P. Holmquist","year":"1992","unstructured":"Holmquist, G.P.: Chromosome bands, their chromatin flavors, and their functional features. Am. J. Hum. Genet.\u00a051(1), 17\u201337 (1992)","journal-title":"Am. J. Hum. Genet."},{"key":"17_CR41","volume-title":"Molecular Biology of the Cell","author":"B. Alberts","year":"2002","unstructured":"Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P.: Molecular Biology of the Cell. Garland Science, New York (2002), \n                  \n                    http:\/\/www.ncbi.nlm.nih.gov\/books\/bv.fcgi?rid=mboc4"},{"key":"17_CR42","unstructured":"Collins, F.S.: The Language of Life: DNA and the Revolution in Personalized Medicine. Harper Colllins Publishers (2010)"},{"key":"17_CR43","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nature06884","volume":"452","author":"D.A. Wheeler","year":"2008","unstructured":"Wheeler, D.A., et al.: The complete genome of an individual by massively parallel DNA sequencing. Nature\u00a0452, 872\u2013877 (2008)","journal-title":"Nature"}],"container-title":["Lecture Notes in Computer Science","Conceptual Modelling and Its Theoretical Foundations"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-28279-9_17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T09:21:52Z","timestamp":1556356912000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-28279-9_17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"ISBN":["9783642282782","9783642282799"],"references-count":43,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-28279-9_17","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2012]]}}}